cloprostenol and carbetocin

The effects of various parturition controlling measures in sows on the relevant parameters for parturition were investigated.. A total of 1975 study animals were divided into five groups: control group: A (n = 710); trial groups: B (n = 719), C (n = 180), D (n = 175), E (n = 191). The control group (A) included sows that spontaneously farrowed until day 114 of gestation. The remaining sows were administered a PGF2α-analogue (175 µg cloprostenol) on day 114. All sows that farrowed within 24 hours after prostaglandin-medication were summarised in trial group B. Dams that did not farrow until day 115 were either administered oxytocin (20 IU i. m., group C) or carbetocin in two different doses (70 µg, group D or 35 µg, group E). The sows were monitored during the peripartal period over 24 hours.. 83.8% of the farrowings were without any complications. The percentage of dystocia varied between the individual groups. Given a complication-free farrowing the expulsion stage began 13.0 hours (group B), 2.4 hours (group C), 1.6 hours (group D) and 1.4 hours (group E) after medication. The expulsion interval of the farrowing of two piglets decreased from 21.1 minutes with spontaneous farrowings (group A) to 18.6 minutes (group E) as a result of the administration of 35 µg carbetocin. The rate of stillborn piglets as well as the incidence of puerperal disorders and the losses of the suckling piglets also gradually, partly even significantly (p ≤ 0.05) decreased from group A to E.. The results of this study show that the use of the long-acting oxytocin carbetocin has advantages compared to oxytocin (e.   g. shortened duration of birth, reduction of stillbirths). The tested dosages of carbetocin (35 µg or 70 µg) proved to be equally effective. Administration of the lower dose is recommended, since this reduces use of the active ingredient.

Topics: Animals; Breeding; Cloprostenol; Estrus Synchronization; Female; Oxytocin; Parturition; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Stillbirth; Swine

Partus induction is an important integrative component of reproduction management in the swine industry. In this context, the question is to what extent the application of uterotonic substances may influence the vitality of piglets. The blood pH value is used as a laboratory objective diagnostic parameter of neonatal acidosis. This parameter of the acid-base balance was examined in piglets born spontaneously at the 115th to 116th day of gestation (group 1, n = 57) and after two different partus induction protocols starting at the 114th day of gestation (group 2: combination of 175 microg of cloprostenol and 20 IU of oxytocin, n = 55; group 3: 175 microg of cloprostenol and 35 microg of carbetocin, n = 56). Initial blood samples were taken from each piglet at birth and 2 h later. The results show that the different protocols have no negative influence on the initial pH value and the compensation of neonatal acidosis until the second hour post-natum.

Topics: Acid-Base Equilibrium; Acidosis; Aging; Animals; Animals, Newborn; Blood Gas Analysis; Cloprostenol; Female; Hydrogen-Ion Concentration; Labor, Induced; Labor, Obstetric; Male; Oxytocics; Oxytocin; Pregnancy; Random Allocation; Swine; Swine Diseases; Time Factors

The trials were conducted on a pig farm (German Landrace) over a period of about two years. This farm worked in 7-day cycles using artificial insemination. In trial 1, 209 sows were treated with the prostaglandin F2 alpha analog Cloprostenol (Cloprostenol Jenapharm, 87.5 micrograms i.m.). In trial 2, 646 sows were divided into two groups. Both groups were treated with 100 micrograms Cloprostenol Jenapharm not earlier than on the 113th day of gestation (day 1 of gestation = the day after the first insemination). 24 h later, 119 sows received an additional injection of 1 ml of an oxytocin analog (Depotocin inj. Spofa, 1 ml contains 0.2 mg Carbetocin). In the other group, 120 sows received 2 ml Depotocin. This additional treatment with Depotocin resulted in a mean interval from the injection to the onset of farrowing of 125 minutes (gilts) and 49 minutes (sows). In trial 2, 97.9% of the sows farrowed within 30 hours after Cloprostenol injection (= partus rate 30). The additional treatment with Depotocin resulted in a shortening of farrowing periods, a reduction in mean expulsion time and effected an increase in farrowing during the day time. All these effects were significant (p < or = 0.05).

Topics: Animals; Cloprostenol; Female; Labor, Induced; Labor, Obstetric; Oxytocics; Oxytocin; Pregnancy; Swine