cloperastine and piperidines

cloperastine has been researched along with piperidines in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.00)29.6817
2010's7 (35.00)24.3611
2020's7 (35.00)2.80

Authors

AuthorsStudies
Borzani, M; Scotti, L1
Allegra, L; Bossi, R1
Canti, G; Franco, P; Nicolin, A1
Aliprandi, P; Bernorio, S; Carrara, M; Castelli, C; Dell'Abate, E1
Otsuka, M; Sakata, Y; Shiraishi, S; Sumikawa, T; Tanabe, E; Tokudome, Y1
Fawcett, JP; Gu, J; Jiang, Y; Li, H; Wang, J; Zhang, C1
Shirasaki, T; Soeda, F; Takahama, K; Yamamoto, G2
Honda, S; Kawaura, K; Shirasaki, T; Soeda, F; Takahama, K1
Hirakawa, E; Inoue, M; Shirasaki, T; Soeda, F; Takahama, K1
Barbas, C; Ceppa, F; García, A; Pellati, F; Rupérez, FJ1
Hayek, LF; Perez-Dueñas, B; Sanz-Cuesta, M; Serrano, M; Villaronga, M1
Fujiwara, K; Namekata, I; Ohtsuki, A; Oka, T; Takahara, A; Tanaka, H1
Civardi, C; Collini, A; Enrico, E; Geda, C; Maggio, M1
Guo, X; Jiang, Z; Lun, J; Song, Y; Zhao, P1
Cui, N; Jiang, C; Johnson, CM; Wu, Y; Xing, H1
Cheng, QZ; Fu, HZ; Guo, YF; Liu, HY; Xia, HY; Yu, SS; Zheng, SS; Zhong, ZH1
Ebihara, M; Fujimoto, Y; Imamura, T; Matsumoto, N; Oishi, S; Okada, T1
Ekins, S; Puhl, AC; Urbina, F1
Huang, J; Li, F; Shao, L; Shi, G; Wang, X; Wu, K; Yan, J; Yang, L; Yin, X1

Reviews

4 review(s) available for cloperastine and piperidines

ArticleYear
Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.
    Drugs under experimental and clinical research, 2004, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Aged; Antitussive Agents; Bronchitis; Chronic Disease; Clinical Trials as Topic; Codeine; Cough; Female; Humans; Lung Diseases; Male; Middle Aged; Patient Selection; Piperidines; Propylene Glycols; Stereoisomerism; Treatment Outcome

2004
[Novel antidepressant-like action of drugs possessing GIRK channel blocking action in rats].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2010, Volume: 130, Issue:5

    Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Cyclopentanes; Disease Models, Animal; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Male; Piperidines; Rats; Rats, Wistar

2010
[Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance?].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:4

    Topics: Animals; Antitussive Agents; Brain; Cerebral Infarction; Dextromethorphan; Drug Design; Dysuria; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Molecular Targeted Therapy; Piperidines; Rats; Serotonin; Urinary Bladder, Overactive

2011
Recent advances in drug repurposing using machine learning.
    Current opinion in chemical biology, 2021, Volume: 65

    Topics: Alzheimer Disease; Antineoplastic Agents; Antiviral Agents; Clemastine; Computational Biology; COVID-19 Drug Treatment; Dipyridamole; Drug Repositioning; Humans; Hydroxychloroquine; Lenalidomide; Machine Learning; Neoplasms; Neuroprotective Agents; Piperazines; Piperidines; Protein Kinase Inhibitors

2021

Trials

2 trial(s) available for cloperastine and piperidines

ArticleYear
[Cloperastine fendizoate in the treatment of cough-producing diseases in pediatrics].
    Minerva pediatrica, 1988, Volume: 40, Issue:5

    Topics: Acute Disease; Antitussive Agents; Bronchitis; Child; Child, Preschool; Clinical Trials as Topic; Cough; Double-Blind Method; Female; Humans; Male; Piperidines; Random Allocation

1988
Clinical trials with the new antitussive levodropropizine in adult bronchitic patients.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitussive Agents; Benzophenones; Bronchitis; Clinical Trials as Topic; Cough; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Piperidines; Propylene Glycols

1988

Other Studies

14 other study(ies) available for cloperastine and piperidines

ArticleYear
[The pharmacologic activity of 1(2-(p-chloro-alpha-phenylbenzyloxy)ethyl)piperidine (cloperastine)].
    Bollettino chimico farmaceutico, 1983, Volume: 122, Issue:8

    Topics: Animals; Antitussive Agents; Female; Guinea Pigs; Histamine H1 Antagonists; Male; Mice; Piperidines; Rats; Rats, Inbred Strains; Sleep

1983
Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations.
    International journal of pharmaceutics, 2007, Apr-20, Volume: 335, Issue:1-2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitussive Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Combinations; Drug Stability; Hardness; Hydrogen Bonding; Microscopy, Electron, Scanning; Phase Transition; Piperidines; Powders; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; Technology, Pharmaceutical; Temperature; Time Factors

2007
Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2010, Feb-05, Volume: 51, Issue:3

    Topics: Acetaminophen; Caffeine; Chlorpheniramine; Chromatography, Liquid; Evaluation Studies as Topic; Humans; Male; Piperidines; Pseudoephedrine; Tandem Mass Spectrometry

2010
Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:11

    Topics: Animals; Antitussive Agents; Ataxia; Dextromethorphan; Diagnostic Techniques, Urological; Infarction, Middle Cerebral Artery; Male; Piperidines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Bladder, Overactive; Urination

2009
Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol.
    Environmental toxicology, 2014, Volume: 29, Issue:2

    Topics: Animals; Antitussive Agents; Avoidance Learning; Brain-Derived Neurotrophic Factor; Diethylstilbestrol; Endocrine Disruptors; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hippocampus; Learning Disabilities; Male; Mice; Neuroprotective Agents; Piperidines; Pregnancy; Prenatal Exposure Delayed Effects; Receptor, Serotonin, 5-HT1A

2014
Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate.
    Journal of pharmaceutical and biomedical analysis, 2012, Mar-05, Volume: 61

    Topics: Chromatography; Chromatography, High Pressure Liquid; Drug Contamination; Gas Chromatography-Mass Spectrometry; Mutagenicity Tests; Piperidines

2012
Cloperastine-based cough syrup and acute dystonic reactions.
    Developmental medicine and child neurology, 2012, Volume: 54, Issue:3

    Topics: Antitussive Agents; Child; Cough; Dystonia; Female; Humans; Piperidines

2012
Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs.
    Journal of pharmacological sciences, 2012, Volume: 120, Issue:3

    Topics: Action Potentials; Amino Alcohols; Animals; Animals, Inbred Strains; Anti-Arrhythmia Agents; Antitussive Agents; Diphenhydramine; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Heart Ventricles; HEK293 Cells; Humans; Long QT Syndrome; Membrane Potentials; Osmolar Concentration; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Recombinant Proteins; Structure-Activity Relationship

2012
Induced hemichorea by cloperastine overuse.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020, Volume: 41, Issue:7

    Topics: Chorea; Humans; Piperidines

2020
Enantioselective LC-MS/MS method for the determination of cloperastine enantiomers in rat plasma and its pharmacokinetic application.
    Chirality, 2020, Volume: 32, Issue:8

    Topics: Animals; Chromatography, Liquid; Limit of Detection; Piperidines; Rats; Stereoisomerism; Tandem Mass Spectrometry; Tissue Distribution

2020
The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release.
    Neuropharmacology, 2020, 10-01, Volume: 176

    Topics: Animals; Antitussive Agents; Brain Stem; Dose-Response Relationship, Drug; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Mice; Mice, Transgenic; Organ Culture Techniques; Piperidines; Potassium Channel Blockers; Presynaptic Terminals; Rats; Respiration; Rett Syndrome

2020
Identification and quantification of five impurities in cloperastine hydrochloride.
    Journal of pharmaceutical and biomedical analysis, 2021, Jan-30, Volume: 193

    Topics: Chromatography, High Pressure Liquid; Drug Contamination; Magnetic Resonance Spectroscopy; Piperidines

2021
Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells.
    Scientific reports, 2021, 01-15, Volume: 11, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Fibroblast Growth Factors; Gene Expression; Gene Expression Regulation, Neoplastic; HeLa Cells; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Neoplasms; Piperidines; Receptors, Histamine H1

2021
Efficient synthesis of bepotastine and cloperastine intermediates using engineered alcohol dehydrogenase with a hydrophobic pocket.
    Applied microbiology and biotechnology, 2021, Volume: 105, Issue:14-15

    Topics: Alcohol Dehydrogenase; Biocatalysis; Hydrophobic and Hydrophilic Interactions; Kinetics; Piperidines; Pyridines; Stereoisomerism

2021