clonidine and valproic acid

clonidine has been researched along with valproic acid in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (17.95)	18.7374
1990's	10 (25.64)	18.2507
2000's	13 (33.33)	29.6817
2010's	8 (20.51)	24.3611
2020's	1 (2.56)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA	1
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Cuddon, P; Fleming, A; Floto, RA; Goldsmith, P; Jahreiss, L; O'Kane, CJ; Pask, D; Rubinsztein, DC; Saiki, S; Sarkar, S; Siddiqi, FH; Ttofi, EK; Williams, A	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Hansson, E; Nilsson, M; Rönnbäck, L	1
de Chiara, BM; Genazzani, AD; Genazzani, AR; Montemagno, R; Montemagno, U; Nappi, C; Petraglia, F	1
Andreev, BV; Ignatov, IuD	1
Cookson, JC	1
Dirksen, R; Van der Laan, JW	1
Green, AR; Johnson, P; Mountford, JA; Nimgaonkar, VL	1
Lerer, B	1
Hillen, FC; van der Laan, JW; Weick, G	1
Bremner, KE; Naranjo, CA; Ozdemir, V	1
Bhatara, VS; Carrera, J	1
Kazamatsuri, H	1
Dilsaver, SC; Minkus, D; Swann, AC	1
de Angelis, L	1
Louie, J; Oftadeh, LC; Oh, C; Song, CH; Yu, KT	1
Cohen, D; Flament, MF; Gérardin, P; Mazet, P	1
Cummings, MR; Miller, BD	1
Mendhekar, DN	1
Cummins, TK; Kratochvil, CJ; Martin, A; Varley, C	1
Clausen, T; Isaksen, A; Kristensen, Ø; Lølandsmo, T; Vederhus, JK	1
D'Amico, D	1
Bamford, A; Clarke, A; Crowe, BH; Hacohen, Y; Lim, M; Lin, JP; Pullaperuma, SP; Sancho-Shimizu, V; Tudor-Williams, G; Vincent, A	1
Clausen, T; Dunsæd, F; Høie, MM; Kristensen, Ø; Vederhus, JK	1
Fontaine, GV; Fraser, GL; Gagnon, DJ; Riker, RR	1
Aletraris, L; Paino, M; Roman, PM	1

Reviews

7 review(s) available for clonidine and valproic acid

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug treatment of bipolar depression and mania. British journal of hospital medicine, 1985, Volume: 34, Issue:3 Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Bromocriptine; Carbamazepine; Cholinesterase Inhibitors; Clonidine; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Humans; Lithium; Monoamine Oxidase Inhibitors; Phosphatidylcholines; Tryptophan; Valproic Acid; Verapamil	1985
Alternative therapies for bipolar disorder. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:8 Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgyline; Demeclocycline; Fenfluramine; Humans; Methylene Blue; Phosphatidylcholines; Physostigmine; Propiophenones; Propranolol; Spironolactone; Thyroxine; Tryptophan; Valproic Acid	1985
Treatment of alcohol withdrawal syndrome. Annals of medicine, 1994, Volume: 26, Issue:2 Topics: Adrenergic beta-Antagonists; Benzodiazepines; Carbamazepine; Clonidine; Ethanol; Humans; Substance Withdrawal Syndrome; Valproic Acid	1994
[Tardive dyskinesia--diagnosis and treatment]. Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:11 Topics: Clonidine; Diagnosis, Differential; Dyskinesia, Drug-Induced; Humans; Middle Aged; Psychotropic Drugs; Valproic Acid	1993
Pharmacologic management of behavioral instability in medically ill pediatric patients. Current opinion in pediatrics, 2004, Volume: 16, Issue:5 Topics: Adolescent; Adrenergic alpha-Agonists; Aggression; Analgesics, Non-Narcotic; Behavior Therapy; Behavioral Medicine; Benzodiazepines; Carbamazepine; Central Nervous System Stimulants; Child; Clonidine; Diphenhydramine; Histamine H1 Antagonists; Humans; Lithium; Methylphenidate; Psychomotor Agitation; Valproic Acid	2004
Repurposing Valproate, Enteral Clonidine, and Phenobarbital for Comfort in Adult ICU Patients: A Literature Review with Practical Considerations. Pharmacotherapy, 2017, Volume: 37, Issue:10 Topics: Administration, Oral; Administration, Sublingual; Adult; Clonidine; Critical Illness; Drug Repositioning; Humans; Hypnotics and Sedatives; Intensive Care Units; Patient Comfort; Phenobarbital; Valproic Acid	2017

Trials

2 trial(s) available for clonidine and valproic acid

Article	Year
The effect of various drugs with neuroendocrine activity and transdermal estradiol on plasma gonadotropin concentrations after ovariectomy in reproductive-aged women. Acta obstetricia et gynecologica Scandinavica, 1991, Volume: 70, Issue:6 Topics: Administration, Cutaneous; Adult; Climacteric; Clonidine; Estradiol; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone; Humans; Lisuride; Luteinizing Hormone; Ovariectomy; Valproic Acid	1991
Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment. BMC psychiatry, 2006, Nov-15, Volume: 6 Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Buprenorphine; Carbamazepine; Clonidine; Comorbidity; Drug Therapy, Combination; Female; Hospitalization; Humans; Male; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome; Valproic Acid	2006

Article

Year

The effect of various drugs with neuroendocrine activity and transdermal estradiol on plasma gonadotropin concentrations after ovariectomy in reproductive-aged women.

Acta obstetricia et gynecologica Scandinavica, 1991, Volume: 70, Issue:6

Topics: Administration, Cutaneous; Adult; Climacteric; Clonidine; Estradiol; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone; Humans; Lisuride; Luteinizing Hormone; Ovariectomy; Valproic Acid

1991

Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment.

BMC psychiatry, 2006, Nov-15, Volume: 6

Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Buprenorphine; Carbamazepine; Clonidine; Comorbidity; Drug Therapy, Combination; Female; Hospitalization; Humans; Male; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome; Valproic Acid

2006

Other Studies

30 other study(ies) available for clonidine and valproic acid

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1 Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mice; Molecular Structure; Muscle Spasticity; Paralysis; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Strychnine; Triazoles	1994
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nature chemical biology, 2008, Volume: 4, Issue:5 Topics: Animals; Autophagy; Calcium Channels, L-Type; Clonidine; Cyclic AMP; Humans; Huntington Disease; Imidazoline Receptors; Minoxidil; Protein Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Type C Phospholipases; Verapamil	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Receptor-coupled uptake of valproate in rat astroglial primary cultures. Neuroscience letters, 1992, Feb-17, Volume: 136, Issue:1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Clonidine; Drug Interactions; Glutamates; Glutamic Acid; Isoproterenol; Kainic Acid; Ketanserin; Phenylephrine; Prazosin; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin; Valproic Acid; Yohimbine	1992
[Role of opioid and adrenergic mechanisms in the analgesic action of GABA-positive drugs]. Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:5 Topics: 4-Aminobutyrate Transaminase; Analgesics; Animals; Baclofen; Clonidine; Drug Tolerance; Female; Male; Morphine; Nociceptors; Pain Measurement; Rats; Receptors, Adrenergic, alpha; Receptors, GABA-A; Valproic Acid	1988
Dipropylacetate-induced shaking behaviour in the rat: a role of spinal alpha 2-adrenoceptors. European journal of pharmacology, 1988, Aug-02, Volume: 152, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Idazoxan; Injections, Intraventricular; Male; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Valproic Acid	1988
Some anticonvulsant drugs alter monoamine-mediated behaviour in mice in ways similar to electroconvulsive shock; implications for antidepressant therapy. British journal of pharmacology, 1985, Volume: 84, Issue:2 Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Antidepressive Agents; Apomorphine; Behavior, Animal; Biogenic Amines; Clonidine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Radioligand Assay; Receptors, Adrenergic, beta; Receptors, Serotonin; Valproic Acid	1985
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: suppression by alpha 2-adrenoceptor stimulation. Psychopharmacology, 1983, Volume: 81, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Humans; Male; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Valproic Acid	1983
Medications for aggressiveness. Journal of the American Academy of Child and Adolescent Psychiatry, 1994, Volume: 33, Issue:2 Topics: Aggression; Carbamazepine; Child; Child Behavior Disorders; Clonidine; Electroencephalography; Hallucinations; Humans; Male; Valproic Acid	1994
Chronic treatment with valproate decreases the hypothermic response to clonidine. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:1 Topics: Animals; Body Temperature; Clonidine; Male; Rats; Rats, Sprague-Dawley; Valproic Acid	1993
Effects of valproate and lorazepam on experimental anxiety: tolerance, withdrawal, and role of clonidine. Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Clonidine; Drug Tolerance; Female; Injections, Intraperitoneal; Lorazepam; Mice; Substance Withdrawal Syndrome; Valproic Acid	1995
Successful treatment of steroid-resistant chorea associated with lupus by use of valproic acid and clonidine-HCL patch. Clinical pediatrics, 1997, Volume: 36, Issue:11 Topics: Administration, Oral; Adolescent; Chorea; Clonidine; Female; Humans; Injections, Intravenous; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Methylprednisolone; Prednisone; Valproic Acid	1997
Drug treatment of conduct disorder in young people. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:5 Topics: Adolescent; Adrenergic alpha-Agonists; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Central Nervous System Stimulants; Child; Child Behavior Disorders; Child, Preschool; Clonidine; Conduct Disorder; Humans; Lithium; Randomized Controlled Trials as Topic; Valproic Acid	2002
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. The Journal of clinical psychiatry, 2005, Volume: 66, Issue:12 Topics: Age Factors; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comorbidity; Gynecomastia; Humans; Hyperprolactinemia; Male; Methylphenidate; Seizures; Valproic Acid	2005
Less is more: inpatient management of a child with complex pharmacotherapy. Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:5 Topics: Aggression; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Depression; Dibenzothiazepines; Domestic Violence; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Irritable Mood; Length of Stay; Male; Methylphenidate; Patient Admission; Psychiatric Department, Hospital; Psychomotor Agitation; Psychotropic Drugs; Quetiapine Fumarate; Recurrence; Sertraline; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Valproic Acid	2006
Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2010, Volume: 31 Suppl 1 Topics: Amines; Analgesics; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Double-Blind Method; Fructose; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Randomized Controlled Trials as Topic; Topiramate; Valproic Acid	2010
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis. Journal of the Pediatric Infectious Diseases Society, 2015, Volume: 4, Issue:2 Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonidine; Diazepam; Encephalitis, Herpes Simplex; Encephalomalacia; Female; Fever; Humans; Immunocompromised Host; Immunosuppression Therapy; Infant; Leukoencephalopathies; Movement Disorders; Neurological Rehabilitation; Pakistan; Paresis; Phenobarbital; Phenytoin; Plasmapheresis; Receptors, N-Methyl-D-Aspartate; Seizures; Trihexyphenidyl; United Kingdom; Valproic Acid	2015
Standardised detoxification in cases of polydrug use. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2016, Volume: 136, Issue:19 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Anticonvulsants; Clonidine; Cohort Studies; Female; Humans; Male; Middle Aged; Norway; Patient Dropouts; Program Evaluation; Socioenvironmental Therapy; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome; Valproic Acid; Young Adult	2016
The use of off-label medications in substance abuse treatment programs. Substance abuse, 2020, Volume: 41, Issue:3 Topics: Accreditation; Adrenergic alpha-2 Receptor Agonists; Anticonvulsants; Antiemetics; Baclofen; Clonidine; Excitatory Amino Acid Antagonists; GABA Agents; Gabapentin; Health Facility Size; Humans; Logistic Models; Off-Label Use; Ondansetron; Practice Patterns, Physicians'; Substance Abuse Treatment Centers; Substance-Related Disorders; Time Factors; Topiramate; United States; Valproic Acid	2020