Compounds > clonidine

clonidine and urapidil

clonidine has been researched along with urapidil in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199013 (44.83)18.7374
1990's8 (27.59)18.2507
2000's6 (20.69)29.6817
2010's2 (6.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Campillo, NE; Guerra, A; Páez, JA1
Kotai, E; Singer, EA; Valenta, B; Weisz, E1
Ramage, AG1
Hess, W1
Ramage, AG; Wilkinson, SJ1
Caccia, MR; Cataldi, G; Galimberti, V; Mangoni, A; Osio, M1
Feuerstein, TJ; Hertting, G; Jackisch, R; Kasakov, L1
Shebuski, RJ; Zimmerman, BG1
Kilian, U; Kolassa, N; Sanders, KH; Schoetensack, W1
Bielefeld, FW; Schümann, HJ1
Heikkilä, O; Jääskeläinen, T; Jounela, AJ; Kanniainen, E; Lilja, M1
Becker, H; Ganten, D; Lang, RE; Luft, FC; Unger, T; Veelken, R1
Jurna, I; Sanders, KH1
Beckeringh, JJ; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B1
Buller, A; Conforti, A; Dias Souza, J; Gillis, RA; Kellar, KJ; Quest, JA; Spera, AC1
Kaplan, HR; Smith, RD1
Timmermans, PB; Van Brummelen, P; Van Zwieten, PA1
Compagnon, P; Fresel, J; Joannidès, R; Moore, N; Thuillez, C1
Cozian, A; Hélias, J; Lepage, JY; Malinovsky, JM; Petitet, A; Pinaud, M; Souron, R1
Asano, M; Honda, K; Inagaki, O; Kawabe, K; Kimura, R; Mori, R; Suzuki, M; Takenaka, T; Tanaka, C; Yamada, S1
Cozian, A; De Dieuleveult, C; Lepage, JY; Malinovsky, JM; Petitet, A; Pinaud, M; Souron, R1
Dakshinamurti, K; Lal, KJ1
Boldt, J; Maleck, WH; Piper, SN; Reich, DG; Schmidt, CC; Suttner, SW1
Fritz, HG; Hartmann, M; Hoff, H; Schwarzkopf, KR1
Boldt, J; Fent, MT; Maleck, WH; Piper, SN; Röhm, KD; Suttner, SW1
Stiefelhagen, P1
Anderson, FA; de La Garanderie, DP; Emery, L; Gore, JM; Rushton-Smith, S; Vincent, JL; Vuylsteke, A; Wyman, A1

Reviews

1 review(s) available for clonidine and urapidil

ArticleYear
Role of alpha adrenoceptors in hypertension and in antihypertensive drug treatment.
    The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Calcium Channel Blockers; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Ketanserin; Methyldopa; Muscle, Smooth, Vascular; Phenylacetates; Piperazines; Piperidines; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Vascular Resistance

1984

Trials

9 trial(s) available for clonidine and urapidil

ArticleYear
Urapidil versus clonidine. Acute haemodynamic effects during control of intraoperative hypertensive episodes.
    Drugs, 1990, Volume: 40 Suppl 4

    Topics: Antihypertensive Agents; Clonidine; Coronary Artery Bypass; Double-Blind Method; Hemodynamics; Humans; Hypertension; Intraoperative Care; Piperazines

1990
Propranolol, clonidine, urapidil and trazodone infusion in essential tremor: a double-blind crossover trial.
    Acta neurologica Scandinavica, 1989, Volume: 79, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Clonidine; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Middle Aged; Piperazines; Propranolol; Trazodone; Tremor

1989
Antihypertensive effects of urapidil and clonidine: a double-blind cross-over study.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:1

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Physical Exertion; Piperazines; Random Allocation

1985
A comparison of the hemodynamic effects of urapidil, prazosin, and clonidine in healthy volunteers.
    Blood pressure. Supplement, 1994, Volume: 4

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Administration Schedule; Heart Rate; Humans; Male; Norepinephrine; Piperazines; Prazosin; Vascular Resistance

1994
Acute effects of urapidil on left ventricular function in hypertensive patients: comparison with clonidine using radionuclide angiography.
    British journal of anaesthesia, 1994, Volume: 72, Issue:6

    Topics: Adrenergic alpha-Antagonists; Aged; Clonidine; Double-Blind Method; Heart; Hemodynamics; Humans; Hypertension; Middle Aged; Piperazines; Radionuclide Angiography; Ventricular Function, Left

1994
[Is urapidil a venodilator?].
    Annales francaises d'anesthesie et de reanimation, 1993, Volume: 12, Issue:5

    Topics: Atrial Natriuretic Factor; Blood Pressure; Clonidine; Humans; Male; Piperazines; Stroke Volume; Supine Position; Vasodilator Agents; Veins; Ventricular Function, Right

1993
A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:4

    Topics: Adult; Aged; Anesthesia, General; Clonidine; Double-Blind Method; Female; Hemodynamics; Humans; Male; Meperidine; Middle Aged; Piperazines; Shivering

2000
A comparison between meperidine, clonidine and urapidil in the treatment of postanesthetic shivering.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, General; Blood Pressure; Clonidine; Double-Blind Method; Female; Humans; Male; Meperidine; Oxygen; Piperazines; Shivering

2001
Urapidil does not prevent postanesthetic shivering: a dose-ranging study.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:8

    Topics: Adult; Aged; Anesthesia, General; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Shivering

2001

Other Studies

19 other study(ies) available for clonidine and urapidil

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Influence of urapidil and 8-OH-DPAT on brain 5-HT turnover and blood pressure in rats.
    Journal of cardiovascular pharmacology, 1990, Volume: 15 Suppl 7

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Brain Chemistry; Clonidine; Heart Rate; Male; Piperazines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Spinal Cord; Stereotaxic Techniques; Tetrahydronaphthalenes

1990
The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors.
    British journal of pharmacology, 1991, Volume: 102, Issue:4

    Topics: Anesthesia; Animals; Blood Pressure; Cats; Clonidine; Heart; Heart Rate; Kidney; Male; Piperazines; Prazosin; Receptors, Serotonin; Regional Blood Flow; Spiperone; Splanchnic Nerves; Sympatholytics

1991
Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and alpha 2-adrenoceptor agonists in anaesthetized cats.
    British journal of pharmacology, 1989, Volume: 98, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Anesthesia; Animals; Cats; Clonidine; Hemodynamics; Imidazoles; Male; Piperazines; Receptors, Serotonin; Sympathetic Nervous System; Tetrahydronaphthalenes

1989
Effects of urapidil on neurotransmitter release in CNS tissue in vitro.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 285, Issue:1

    Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Caudate Nucleus; Clonidine; Dopamine; Electric Stimulation; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Norepinephrine; Piperazines; Rabbits; Serotonin

1987
Prejunctional alpha 2-adrenoceptor mediated inhibitory action of clonidine and B-HT 920, but not urapidil in guinea pig ileum.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 178, Issue:1

    Topics: Animals; Azepines; Clonidine; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Receptors, Adrenergic, alpha

1985
Influence of urapidil on alpha- and beta-adrenoreceptors in pithed rats.
    Journal of autonomic pharmacology, 1985, Volume: 5, Issue:4

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta

1985
The effect of urapidil on cardiac alpha- and beta-adrenoceptors.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:10

    Topics: Animals; Clonidine; Drug Interactions; Female; Fenoterol; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Norepinephrine; Phenylephrine; Piperazines; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta

1986
Effect of urapidil, clonidine, and prazosin on sympathetic tone in conscious rats.
    Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:4

    Topics: Animals; Blood Pressure; Clonidine; Electrodes; Heart Rate; Piperazines; Prazosin; Pressoreceptors; Rats; Rats, Inbred SHR; Splanchnic Nerves; Sympathetic Nervous System

1986
Effects of urapidil, clonidine, prazosin and propranolol on autonomic nerve activity, blood pressure and heart rate in anaesthetized rats and cats.
    European journal of pharmacology, 1985, Apr-02, Volume: 110, Issue:2

    Topics: Anesthesia; Animals; Antihypertensive Agents; Autonomic Nervous System; Blood Pressure; Cats; Clonidine; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Neurons; Piperazines; Prazosin; Propranolol; Quinazolines; Rats; Rats, Inbred Strains; Species Specificity; Splanchnic Nerves; Sympathetic Nervous System; Vagus Nerve

1985
Cardiovascular effects and interaction with adrenoceptors of urapidil.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 276, Issue:2

    Topics: Animals; Antihypertensive Agents; Binding, Competitive; Cats; Clonidine; Decerebrate State; Female; Hemodynamics; Hexobarbital; In Vitro Techniques; Infusions, Parenteral; Male; Membranes; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Piperazines; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Adrenergic

1985
Comparative effects of urapidil, prazosin, and clonidine on ligand binding to central nervous system receptors, arterial pressure, and heart rate in experimental animals.
    The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A

    Topics: Animals; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Brain; Cats; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Piperazines; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Muscarinic

1984
Antihypertensive drugs: proposed sites and mechanisms of action.
    Federation proceedings, 1981, Volume: 40, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Denervation; Dogs; Heart Rate; Methysergide; Moxisylyte; Phentolamine; Piperazines; Prazosin; Uracil

1981
Comparative study on alpha 1-adrenoceptor antagonist binding in human prostate and aorta.
    Clinical and experimental pharmacology & physiology, 1994, Volume: 21, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aged; Aorta; Binding Sites; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Humans; Kinetics; Male; Middle Aged; Naphthalenes; Piperazines; Prazosin; Prostate; Sulfonamides; Tamsulosin

1994
Hypotensive action of 5-HT receptor agonists in the vitamin B6-deficient hypertensive rat.
    European journal of pharmacology, 1993, Apr-06, Volume: 234, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Blood Pressure; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Riboflavin Deficiency; Serotonin; Serotonin Receptor Agonists; Yohimbine

1993
[When hypertension becomes an emergency case: lower the blood pressure, but slowly!].
    MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22

    Topics: Administration, Oral; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Diagnosis, Differential; Dihydralazine; Emergencies; Hospitalization; Humans; Hypertension; Hypertension, Malignant; Injections, Intravenous; Nifedipine; Nitrendipine; Nitroglycerin; Piperazines; Time Factors; Vasodilator Agents

2003
Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT).
    Critical care (London, England), 2011, Volume: 15, Issue:6

    Topics: Acute Disease; Aged; Antihypertensive Agents; Blood Pressure; Clonidine; Emergency Service, Hospital; Europe; Female; Furosemide; Hospital Mortality; Humans; Hypertension; Infusions, Intravenous; Intensive Care Units; Male; Middle Aged; Nitroglycerin; Perioperative Care; Piperazines; Practice Patterns, Physicians'

2011