clonidine has been researched along with tizanidine in 389 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (16.20) | 18.7374 |
| 1990's | 82 (21.08) | 18.2507 |
| 2000's | 113 (29.05) | 29.6817 |
| 2010's | 103 (26.48) | 24.3611 |
| 2020's | 28 (7.20) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Agbaba, D; Filipic, S; Nikolic, K | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Duncton, MA; Emerling, DE; Kelly, MG; Nguyen, MT; Vincent, F | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Campean, SJ; Gerstenbrand, F; Lorincz, A; Lörincz, P; Ludin, HP; Ringwald, E | 1 |
| Gerstenbrand, F; Lorincz, A; Ludin, HP; Ringwald, E | 1 |
| Evans, RH; Long, SK; Siarey, RJ | 1 |
| Kigoshi, S; Muramatsu, I | 1 |
| Ariciŏglu, F; Dizdar, Y; Esin, Y; Koyuncuŏglu, H; Uresin, Y | 1 |
| Iwata, N; Kaneko, T; Tanabe, M; Tonohiro, T | 1 |
| Fogelholm, R; Murros, K | 1 |
| Ishizuki, M; Yanagisawa, M | 1 |
| Milanov, IG | 1 |
| Asanuma, M; Hirata, H; Ogawa, N; Ota, Z; Yamamoto, M; Yamawaki, Y | 1 |
| Lang, AE; Riley, DE | 1 |
| Koyama, N; Takahashi, T | 1 |
| Harada, M; Koike, K; Satoh, M; Takayanagi, I | 1 |
| Corboz, M; Palmer, CI; Palmeri, A; Wiesendanger, M | 1 |
| Chen, DF; Corboz, M; Palmer, CI; Palmeri, A; Wiesendanger, M | 1 |
| Fukuda, H; Mishima, A; Ono, H; Ono, S; Vasko, MR | 1 |
| Mitsuzane, K; Miyai, K; Ueno, K | 1 |
| Awaki, E; Kowa, H; Shimomura, T; Takahashi, K | 1 |
| Palmeri, A; Wiesendanger, M | 1 |
| Fukuda, H; Ono, H; Tanabe, M | 1 |
| Dietz, V | 1 |
| Ivankovich, AD; Kroin, JS; Lubenow, TR; McCarthy, RJ; Penn, RD | 2 |
| Cerný, R; Jerábek, J; Krejcová, H; Vyskocilová, M | 1 |
| De Sarro, A; De Sarro, GB | 1 |
| Baker, H; Desai, P; el Masri, W; Frankel, HL; Luckitt, J; Mathias, CJ | 1 |
| Davies, J | 2 |
| Hirst, DR; Koch, P; von Wartburg, BR | 1 |
| Katz, NL; Sanchez, J; Schlemmer, RF; Sobaski, N; Young, JE | 1 |
| Paulig, M; Pellkofer, M | 1 |
| Ciblis, D; Medici, M; Pebet, M | 1 |
| Rice, GP | 2 |
| Kameyama, T; Matsuno, K; Nabeshima, T; Sugimoto, A | 2 |
| Bianchetti, M; Chen, DF; Wiesendanger, M | 1 |
| Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U | 1 |
| Konno, F; Kusunoki, M; Takayanagi, I | 1 |
| Davies, J; Quinlan, JE | 1 |
| Bertholet, A; Buchheit, KH | 1 |
| Chitour, D; Le Bars, D; Villanueva, L | 1 |
| Boisson, D; Eyssette, M; Rohmer, F; Serratrice, G; Warter, JM | 1 |
| Bes, A; Eyssette, M; Pierrot-Deseilligny, E; Rohmer, F; Warter, JM | 1 |
| Bass, B; Bouchard, S; Cameron, MG; Ebers, GC; Hader, W; Noseworthy, JH; Rice, GP; Weinshenker, B | 1 |
| Hoogstraten, MC; Minderhoud, JM; van der Ploeg, RJ; van Marle, S; vd Burg, W; Vreeling, A | 1 |
| Igarashi, S; Yamamura, H; Yanagita, T | 1 |
| Bhuta, S; Jaffe, JM; Tse, FL | 1 |
| Cendrowski, W | 1 |
| Lataste, X; Lyberg, T; Vilming, ST | 1 |
| Nordal, HJ; Oftedal, SI; Slettebø, M; Stien, R | 1 |
| Barkas, WJ; Bouchard, S; Francis, GS; Gendron, D; Lapierre, Y; Tansey, C | 1 |
| Fukuda, H; Kato, F; Kato, K; Matsumoto, K; Miyamoto, M; Mori, T; Nakamura, T; Oka, J; Ono, H | 1 |
| Kameyama, T; Matsuno, K; Nabeshima, T | 2 |
| Klockgether, T; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Kameyama, T; Matsuno, K; Nabeshima, T; Sugimoto, A; Yamada, S | 2 |
| Conrad, B; Meinck, HM | 1 |
| Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K | 3 |
| Delwaide, PJ | 1 |
| Davies, J; Hill, DR; Johnston, SE; Quinlan, JE | 1 |
| Knutsson, E | 2 |
| Lakke, JP; Sie, OG | 1 |
| Ishii, C; Konno, F; Mori, H; Shimizu, M; Sugane, H; Takayanagi, I; Takemasa, T; Yanagida, Y | 1 |
| Croucher, MJ; De Sarro, GB; Meldrum, BS | 1 |
| de Jong, P; Lakke, JP; ten Houten, R; van den Burg, W; van Weerden, TW; Wesseling, H | 1 |
| Hennies, OL | 1 |
| Fryda-Kaurimsky, Z; Müller-Fassbender, H | 1 |
| Brink, EE; Mackel, R; Nakajima, Y | 1 |
| Eadie, MJ; Heazlewood, V; Maruff, P; Symoniw, P | 1 |
| McLellan, DL | 1 |
| Conrad, B; Meinck, HM; Ricker, K | 1 |
| Davies, J; Johnston, SE | 1 |
| Hudgson, P; Newman, PK; Newman, PM; Nogues, M; Weightman, D | 1 |
| Curtis, DR; Leah, JD; Peet, MJ | 1 |
| Muff, S; Smolenski, C; Smolenski-Kautz, S | 1 |
| Gransberg, L; Knutsson, E; Mårtensson, A | 1 |
| Corston, RN; Godwin-Austen, RB; Johnson, F | 1 |
| Bürki, HR; Eichenberger, E; Sayers, AC | 1 |
| Hassan, N; McLellan, DL | 1 |
| Chantraine, A; Van Ouwenaller, C | 1 |
| Aantaa, R; Kanto, J; Kirvelä, O; Räty, H; Taittonen, M | 1 |
| Hirata, K; Koyama, N; Minami, T | 1 |
| Corna, S; Grasso, M; Nardone, A; Schieppati, M | 1 |
| Dills, C; Leiphart, J; Levy, R | 1 |
| Kumeta, Y; Namiki, A; Omote, K; Satoh, O; Sonoda, H; Yamaya, K | 1 |
| Koyuncuoglu, H | 1 |
| Chernenko, OA; Damulin, IV; Iakhno, NN; Ianakaeva, TA; Kondrat'eva, ON; Kur'ianova, PT | 1 |
| Dills, CV; Kim, DL; Leiphart, JW; Levy, RM; Zikel, OM | 1 |
| Fukuda, H; Fukushima, C; Ono, H | 1 |
| Evans, RH; Long, SK; Siarey, RJ; Tulp, MT | 1 |
| Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y | 1 |
| Emre, M; Leslie, GC; Muir, C; Part, NJ; Pokorny, R; Roberts, RC | 2 |
| Young, RR | 1 |
| Delwaide, PJ; Pennisi, G | 1 |
| Birnbaum, G; Carter, JL; Greenstein, J; Lublin, FD; Smith, C | 1 |
| Bugaresti, J; Martinez-Arizala, A; Nance, PW; Shellenberger, K; Sheremata, W | 1 |
| Davis, C; Emre, M; Groves, L; Lataste, X | 1 |
| Coward, DM | 1 |
| Wallace, JD | 1 |
| Georgiev, D; Milanov, I | 1 |
| Aumentado, D; Fromm, GH; Terrence, CF | 1 |
| Fukuda, H; Iwata, N; Kozuka, M; Nakamura, T; Ono, H; Tanabe, M | 1 |
| Brugioni, L; Graziina, A; Luciani, A; Serra, L | 1 |
| Kanto, JH; Miettinen, TJ; Salonen, MA; Scheinin, M | 1 |
| Kubota, K; Lee, TJ; Nomura, S; Sunagane, N; Uruno, T | 1 |
| Dohi, S; Iida, H; Kasamatsu, M; Katoh, H; Takenaka, M; Tashiro, T | 1 |
| Landau, WM | 1 |
| Skoog, B | 1 |
| D'Alessandro, R | 1 |
| de Graaf, EM; Oosterveld, M; Stricker, BH; Tjabbes, T | 1 |
| Kroin, JS; Ono, N; Paice, JA; Penn, RD | 1 |
| Bryson, HM; Wagstaff, AJ | 1 |
| Gnezdilov, AV; Kukushkin, ML; Ovechkin, AM; Reshetniak, VK; Vorobeĭchik, IaM | 1 |
| Cohen, JA; Francis, GS; Hudson, S; Lindsey, JW; Lynch, SG; Mass, MK; Nance, PW; O'Connor, P; Schapiro, RT; Shellenberger, K; Sheremata, WA; Vollmer, T; Whitham, R | 1 |
| Iwasaki, H; Kawamata, M; Kawamata, T; Namiki, A; Omote, K | 1 |
| Guzeva, VI; Shumilina, AP; Skoromets, AA | 1 |
| Danilov, AB; Filatova, EG; Solov'eva, AD | 1 |
| Damulin, IV | 2 |
| Pinelli, A; Spezia, R; Trivulzio, S | 1 |
| Loew, M; Ochs, G; Tonn, J; Toyka, K | 1 |
| Berkman, K; Berkman, MZ; Pamir, MN; Zirh, TA | 1 |
| Czarkowska-Bauch, J; Gladden, MH; Jankowska, E | 1 |
| Beliakov, VV; Burd, GS; Gekht, AB; Iaish, F; Selikhova, MV | 1 |
| Brenner, R; Hyman, N; Knobler, R; O'Brien, M; Stephan, T | 1 |
| Groves, L; Novack, GD; Shah, J; Shellenberger, MK | 1 |
| Altenburg, SP; Farah, MB | 1 |
| Andriĭchuk, EL; Maksimov, OG; Secheĭko, MV | 1 |
| Afonso Pérez, E; Brañas Fernández, F; Lancho Seco, A; Pego Reigosa, R | 1 |
| Berkman, K; Denizbaşi, A; Eşkazan, E; Ozyazgan, S | 1 |
| Enginar, N; Koyuncuoğlu, H; Nurten, A; Yamantürk, P | 1 |
| Brin, IL; Gotlib, VIa; Kurenkov, AL | 1 |
| Asano, T; Dohi, S; Iida, H; Ohta, S; Shimonaka, H | 1 |
| Goodkin, DE; Kita, M | 1 |
| Adone, R; Pagliacci, C; Taricco, M; Telaro, E | 1 |
| Csorba, J; Gerevich, J; Kiss, N; Sós, I | 1 |
| Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E | 1 |
| Berkman, MK; Berkman, MZ; Erbengi, T; Iplikçioğlu, AC; San, T; Sav, A | 1 |
| Noth, J | 1 |
| Johnson, TR; Tobias, JD | 1 |
| Kimura, S; Kontani, H; Tsuji, T | 1 |
| Enomoto, K; Koike, K; Satoh, M | 1 |
| Lake, AE; Saper, JR; Winner, PK | 1 |
| Andersen, JB; Grey, MJ; Ladouceur, M; Nielsen, JB; Sinkjaer, T | 1 |
| Dromerick, A; Gelber, DA; Good, DC; Richardson, M; Sergay, S | 1 |
| Brunner, RM; Guin-Renfroe, S; Johnson, A; Meythaler, JM | 1 |
| Azevedo, MI; Denson, DD; Hord, AH | 1 |
| Azevedo, MI; Chalfoun, AG; Denson, DD; Hord, AH | 1 |
| Nance, PW | 1 |
| Autti-Rämö, I | 1 |
| Schapiro, RT | 1 |
| Smith, TR | 1 |
| Rösche, J | 1 |
| Honda, M; Ono, H; Sato, N; Sekiguchi, Y | 1 |
| Imanaga, K; Inoue, T; Ogawa, R; Ogura, A; Shiga, T; Wajima, Z; Yoshikawa, T | 1 |
| Cantrell, DT; Lake, AE; Saper, JR; White, JR; Winner, PK | 1 |
| Kim, DH; Lee, J; Seo, JH | 1 |
| Anderson, PM; Lloyd, AC; Rushton, DN | 1 |
| Jain, NK; Kulkarni, SK; Singh, A | 1 |
| Ozek, M; Sevgi, S; Uresin, Y | 1 |
| Hammar, I; Jankowska, E | 1 |
| Al-Shahrani, AM | 1 |
| Ivankovich, AD; Kroin, JS; Lubenow, TJ; McCarthy, RJ; Penn, RD | 1 |
| Warner, JS | 1 |
| Kalso, E; Paloheimo, M; Talke, P; Xu, M | 1 |
| Freitag, FG | 1 |
| Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H | 1 |
| Carstens, DD; Frank, E; Moufarrege, G | 1 |
| Agrawal, H; Kaul, N; Mahadik, KR; Paradkar, AR | 1 |
| Marque, P; Maupas, E; Roques, CF; Simonetta-Moreau, M | 1 |
| Backman, JT; Granfors, MT; Laitila, J; Neuvonen, PJ | 2 |
| Ahonen, J; Backman, JT; Granfors, MT; Neuvonen, M; Neuvonen, PJ | 1 |
| Giunti, EJ; Mukand, JA | 1 |
| Imanaga, K; Inoue, T; Ogawa, R; Wajima, Z | 1 |
| Bosco, M; Landi, N; Manfredini, D; Orlando, B; Tognini, F | 1 |
| Beeson, J; Eskenasy, AC; Zullino, DF | 1 |
| Bosco, M; Cantini, E; Manfredini, D; Romagnoli, M | 1 |
| Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA | 1 |
| Adamson, LA; Bosse, GM; Spiller, HA | 1 |
| Yelnik, AP | 1 |
| Benavente Aguilar, I; Capablo Liesa, JL; Gazulla Abío, J | 1 |
| Dills, CV; Leiphart, JW; Levy, RM | 1 |
| Doki, K; Homma, M; Hosono, H; Kohda, Y; Momo, K | 1 |
| Bigal, ME; Rapoport, AM | 1 |
| Cho, K; Fujieda, K; Fukuda, I; Miyamoto, A; Oka, R; Tanaka, H | 1 |
| Backman, JT; Granfors, MT; Neuvonen, M; Neuvonen, PJ | 1 |
| Agrawal, H; Dhaneshwar, SR; Kakad, A; Kaul, N; Patil, B | 1 |
| Gandhimathi, M; Ravi, TK; Varghese, SJ | 1 |
| Abe, T; Akizawa, T; Kamimura, M; Kitabata, Y; Kobata, H; Narukawa, N; Orita, H; Shiizaki, K | 1 |
| Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G | 1 |
| Das, SK; Guha, G; Misra, AK; Ray, BK | 1 |
| Karamursel, S; Ketenci, A; Ozcan, E | 1 |
| Honda, M; Kino, Y; Ono, H; Tanabe, M | 1 |
| Patel, DR; Soyode, O | 1 |
| Cavallari, P; Iglesias, C; Lourenço, G; Marchand-Pauvert, V; Pierrot-Deseilligny, E | 1 |
| Bettucci, D; Calzoni, S; Mantegazza, P; Monaco, F; Testa, L; Viana, M | 1 |
| Adone, R; Pagliacci, MC; Taricco, M; Telaro, E | 1 |
| Backman, JT; Granfors, MT; Neuvonen, PJ | 1 |
| Kandikere, VN; Maurya, S; Mudigonda, K; Nirogi, RV; Shukla, M | 1 |
| Cox, DE; Fowler, D; Levine, B; Moore, KA; Sklerov, JH | 1 |
| He, L; Wu, B; Zhou, M | 1 |
| Backman, JT; Karjalainen, MJ; Laitila, J; Neuvonen, M; Neuvonen, PJ | 1 |
| Dashora, K; Saraf, S | 1 |
| Henney, HR; Kovelesky, RA; Shah, J; Wesnes, KA | 1 |
| Homma, M; Kohda, Y; Momo, K; Ohkoshi, N; Tamaoka, A; Yoshizawa, T | 1 |
| Jacobs, BW; Saulino, M | 1 |
| Backman, JT; Lilja, JJ; Neuvonen, PJ | 1 |
| Gnezdilov, AV; Medvedeva, LA; Samoilova, NV; Syrovegin, AV; Zagorul'ko, OI | 1 |
| Henney, HR; Shah, J | 1 |
| Acham, S; Jakse, N; Kirmeier, R; Payer, M; Schulz, K; Truschnegg, A | 1 |
| Backman, JT; Karjalainen, MJ; Neuvonen, PJ | 2 |
| Kardan, A; Mehr, SE; Samini, M | 1 |
| Backman, JT; Neuvonen, PJ; Schröder, MT | 1 |
| Bilgili, N; Kabayel, DD; Murat, S; Ozdemir, F; Unlu, E | 1 |
| Henney, HR; Kamen, L; Runyan, JD | 1 |
| Henney, HR; Runyan, JD | 1 |
| Abei, M; Homma, M; Hyodo, I; Kohda, Y; Momo, K | 1 |
| Caballero, J; Gonzalez-Blanco, M | 1 |
| Arroyo Riaño, O; Benavente Valdepeñas, A; Palazón García, R | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
| Garay, E; Malanga, G; Reiter, RD | 1 |
| Joshi, N; Soonawalla, DF | 1 |
| He, WX; Li, Q; Lin, LL; Liu, XG; Ou-Yang, HD; Wang, PZ; Zeng, WA; Zhang, ZQ | 1 |
| Barbano, R; Brashear, A; Gracies, JM; Simpson, DM; Yablon, SA | 1 |
| Burke, D; Efendi, H; Ertekin, C; Larsson, LE; Uysal, H | 1 |
| Awan, S; Dai, AI; Wasay, M | 1 |
| Fitzpatrick, A; Henney, HR; Runyan, JD; Stewart, J | 1 |
| Cheevers, CV; Donello, JE; Gil, DW; Kedzie, KM; Manlapaz, CA; Rao, S; Tang, E | 1 |
| Davies, NM; Mutalik, S; Parekh, HS; Udupa, N | 1 |
| Sheean, G | 1 |
| Ambade, R; Bartakke, G; Chandanwale, AS; Chandurkar, N; Gupta, A; Pareek, A | 1 |
| Gonugunta, CS; Kumar, BV; Kumar, CK; Shanker, G; Veerareddy, PR | 1 |
| Akyuz, M; Boyraz, I; Celik, C; Oktay, F; Uysal, H | 1 |
| Homma, M; Inomata, S; Kohda, Y; Momo, K; Osaka, Y; Tanaka, M | 1 |
| Chez, M; Henney, HR | 1 |
| Bensmail, D; Chaleat-Valayer, E; Decq, P; Dehail, P; Dumarcet, N; Marque, P; Parratte, B; Pellas, F; Quentin, V; Rousseaux, M; Simon, O; Trocello, JM; Uzzan, M; Yelnik, AP | 1 |
| Arendzen, JH; de Groot, JH; Meskers, CG; Rich, MM; Schouten, AC; Schuurmans, J | 1 |
| Aisen, M; Ashwal, S; Delgado, MR; Fehlings, DL; Hirtz, D; McLaughlin, J; Morrison, LA; Shrader, MW; Tilton, A; Vargus-Adams, J | 1 |
| af Klint, R; Grey, MJ; Mazzaro, N; Nielsen, JB; Sinkjaer, T | 1 |
| Avakian, GN; Gnezdilov, AV; Medvedeva, LA; Zagorul'ko, OI | 1 |
| D'Amico, D | 1 |
| Auriel, E; Karni, A; Vakhapova, V | 1 |
| Chen, D; Mirbagheri, MM; Rymer, WZ | 1 |
| Benecke, R; Patejdl, R | 1 |
| Le, C; Nguyen, H | 1 |
| Branam, DL; Publow, SW | 1 |
| Kuks, JB; Lapeyre, E; Meijler, WJ | 1 |
| Simon, O; Yelnik, AP | 1 |
| Delgado, MR; Tilton, A; Vargus-Adams, J | 1 |
| Esin, OR; Esin, RG; Naprienko, MV | 1 |
| Drolet, B; Kaddar, N; Patoine, D; Pilote, S; Simard, C; Vigneault, P | 1 |
| Batysheva, TT; Boĭko, AN; Kamchatnov, PR; Petrov, SV; Popova, NF; Zaĭtsev, KA | 1 |
| Chen, CL; Chung, CY; Wong, AM | 1 |
| Chithaluru, K; Kumar, KK; Ramarao, T; Someshwar, K | 1 |
| Bou Khalil, R | 1 |
| Fuchigami, T; Hefferan, MP; Kakinohana, O; Lukacova, N; Marsala, M; Marsala, S; Platoshyn, O; Sugahara, K; Yaksh, TL | 1 |
| Misra, A; Naik, S; Patel, D | 1 |
| Dawaba, M; El-Assmy, MM; El-Hefnawy, AS; Hafez, AT; Helmy, T; Sarhan, O | 1 |
| Inel, SE; Kızılay, F; Özen, H; Pek, G; Uysal, H | 1 |
| Bekö, SL; Bolte, M; Schmidt, MU; Thoms, SD | 1 |
| Mirbagheri, MM; Niu, X; Patel, C; Varoqui, D | 1 |
| Burger, J; Coelho, C; Elgoyhen, AB; Figueiredo, R; Frank, E; Landgrebe, M; Langguth, B; Schecklmann, M | 1 |
| Kim, KH; Park, SC | 1 |
| Camposarcone, N; Di Castelnuovo, A; Garofano, A; Grimani, V; Ianigro, G; Liberatoscioli, G; Nardi, LF; Rossi, M | 1 |
| Heinzlef, O; Monteil-Roch, I | 1 |
| Kindig, M; Mirbagheri, MM; Niu, X; Varoqui, D | 2 |
| Homma, M; Kohda, Y; Matsumoto, S; Momo, K; Sasaki, T | 1 |
| Al-Ghazawi, M; Alzoubi, M; Faidi, B | 1 |
| Gillard, P; Graham, GD; Halpern, R; Varon, SF; Zorowitz, RD | 1 |
| Cardì, F; Drago, F; Piazza, C; Salomone, S; Sinagra, T; Urso, V; Vitale, DC | 1 |
| Heard, K; Le Lait, MC; Wang, GS | 1 |
| Homma, M; Kohda, Y; Momo, K | 1 |
| Thapa, AS | 1 |
| Chu, VW; Hornby, TG; Schmit, BD | 1 |
| Chen, N; He, L; Yang, M; Zakrzewska, JM; Zhang, J; Zhou, M | 1 |
| Hisanaga, R; Nakamura, M; Nomoto, S; Sato, T | 1 |
| Lipták, J | 1 |
| Aboelwafa, AA; El-Gazayerly, ON; El-Mahrouk, GM; Taha, MS | 1 |
| Alencar, FG; Becker, A; Viana, PG; Zamperini, C | 1 |
| Bradshaw, DH; Chapman, CR; Donaldson, GW; Jacobson, RC; Nakamura, Y | 1 |
| Anjum, F; Ghayas, S; Khan, LG; Razvi, N; Siddiqui, SA | 1 |
| Beltrán-Villalobos, KL; Cruz, CA; Déciga-Campos, M; Ramírez-Marín, PM | 1 |
| Brown, GL; Duffell, LD; Mirbagheri, MM | 3 |
| Cortes, J; Hall, B; Redden, D | 1 |
| Al-Saadi, AA; Muthu, S; Sampathkrishnan, S; Sheela, NR | 1 |
| Brown, G; Duffell, LD; Mirbagheri, MM; Niu, X | 1 |
| Gnezdilov, AV; Medvedeva, LA; Oganesyan, GR; Zagorulko, OI | 1 |
| Agafonova, NV; Khasanova, DR; Starostina, GKh | 1 |
| Bayer, D; Bengesser, SA; Kapfhammer, HP; Mörkl, S; Schöggl, H | 1 |
| Fujii, T; Hayasi, A; Hiejima, I; Kumada, T; Miyajima, T; Nozaki, F | 1 |
| Aksoy, SN; Dai, AI; Demiryürek, AT | 1 |
| Zdziarski, P | 1 |
| Duma, SN | 1 |
| Abd-Elsayed, A; Elsharkawy, H; Sakr, W | 1 |
| Adcock, JM; Daniels, JS; Locuson, CW; Williams, P | 1 |
| Esin, OR; Esin, RG; Sitnova, MA | 1 |
| Loos, M; Mueller, MS; Ruff, M; Singer, HP | 1 |
| Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D | 1 |
| Mirbagheri, MM | 1 |
| Alipouramjad, A; Hossainisadr, M; Khanahmadzadeh, S; Seyedsajadi, M; Sheykhaghaei, G | 1 |
| Holroyd, KB; Pahwa, A; Rittenberg, A | 1 |
| Corti, N; Hoppe, L; Kovari, H; Maechler, S; Niedrig, D; Russmann, S | 1 |
| Álvarez-Ossorio, L; Haupts, M; Jonas, A; Vila, C; Witte, K | 1 |
| Comi, G; Gold, R; Hartung, HP; Montalban, X; Otero-Romero, S; Sastre-Garriga, J; Soelberg Sørensen, P; Thompson, AJ; Vermersch, P | 1 |
| Chiba, K; Haraya, K; Kato, M; Sugiyama, Y | 1 |
| Ali Kareem, S; Bavage, S; Dhadde, SB; Durg, S | 1 |
| Kouzouna, A; Lindsay, C; Pandyan, AD; Simcox, C | 1 |
| Bremer, N; Dizdarevic, A | 1 |
| Ali, AA; Moawad, FA; Salem, HF | 1 |
| Hanif, M; Zaman, M | 1 |
| Akbari, M; Ashtari, F; Mellat, M; Taheri, P; Vahdatpour, B | 1 |
| Alto, W; Gianutsos, P; Mancl, L; Plawman, A; Rudolf, G; Rudolf, V; Walsh, J | 1 |
| Achey, R; Bethoux, F; Dai, L; Jones, J; Lang, M; Lee, BS; Lobel, DA; Machado, AG; Nagel, SJ | 1 |
| Belal, F; Derayea, S; Hammad, MA; Omar, MA; Saleh, SF; Zayed, S | 1 |
| Bouffard, J; Bouyer, LJ; Christiansen, L; Jin, A; Kurtzer, I; Nielsen, JB; Scott, SH | 1 |
| Ahiskalioglu, A; Alici, HA; Ari, MA; Celik, EC; Dostbil, A; Doymus, O; Karadeniz, E; Oral Ahiskalioglu, E; Sengoz, F; Yayik, AM | 1 |
| Badshah, M; Khan, AR; Khan, S; Khan, T; Park, JK; Ullah, H | 1 |
| Hanif, M; Shaheryar, ZA; Zaman, M | 1 |
| Fu, X; Li, J; Li, M; Ma, Q; Wang, C; Wang, Y; Wu, H; Yang, W | 1 |
| Jin, Y; Li, X | 1 |
| Donato, AA; Hao, D; Olugbodi, A; Udechukwu, N | 1 |
| Candido, KD; Ghaly, RF; Knezevic, NN; Plesca, A | 1 |
| Aybar, B; Bilici, IŞ; Emes, Y; Yalçın, S | 1 |
| Curkovic, I; Egbring, M; Jödicke, AM; Kullak-Ublick, GA; Neuer, T; Roos, M; Tomka, IT; Zellweger, U | 1 |
| El-Zahry, MR | 1 |
| Niederhofer, H | 1 |
| Katas, H; Rahman, KU; Razzaq, Z; Shahid, N; Siddique, MI; Waqas, MK | 1 |
| Abdelbary, A; Basha, M; El-Hashemy, HA; Khalil, RM; Kocova El-Arini, S | 1 |
| Li, L; Pei, W; Wang, W; Wei, L; Zhao, Y; Zou, Y | 1 |
| Barker, KA; Chaugai, S; Chung, CP; Dickson, AL; Feng, Q; Luther, JM; Shuey, MM; Stein, CM; Wei, WQ | 1 |
| Abouihia, A; Calabrese, A; Cloud, G; Creamer, M; Francisco, GE; Kossmehl, P; Saltuari, L; Ward, AB; Wissel, J; Yochelson, M; Zampolini, M | 1 |
| Brahmane, S; Chabukswar, A; Jagdale, S | 1 |
| Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E | 1 |
| Jiang, WX; Pan, ZX; Sun, YF; Xing, XW; Zhao, J | 1 |
| Pandya, K; Patel, B; Thakkar, H | 1 |
| Carey, RM; Chung, CP; Dominiczak, AF; Jennings, GLR; Luther, JM; Oates, JA; Peixoto, AJ; VanDevender, FK | 1 |
| Biaggioni, I; Farrell, MC; Shibao, CA | 1 |
| Abdelbary, A; Arini, SKE; Basha, M; El-Hashemy, HA; Farouk, F; Khalil, RM | 1 |
| Centonze, D; Comi, G; Leocani, L; Otero-Romero, S; Solari, A | 1 |
| Akifuddin, -; Akram, S; Ali, H; Bashir, L; Ghayas, S; Iqbal, H; Israr, F; Naz, S; Yasmin, R; Zafar, F | 1 |
| Aamir, MN; Ali, L; Anwer, K; Javaid, Z; Shah, MA; Sheikh, FA | 1 |
| Chen, SM; Chen, TW; Mutharani, B; Ranganathan, P; Vinoth Kumar, J | 1 |
| Pramanik, S; Thakkar, H | 1 |
| Ayres, MV; Balsan, ME; de Almeida, SHO; de Saldanha Simon, E; Garcia, CV; Gobetti, C; Oppe, TP; Wingert, NR | 1 |
| Jones, É; Vlachou, S | 1 |
| Adams, A; Copley, C | 1 |
| Burden, A; Dahmke, H; Kupferschmidt, H; Rudolph, A; Weiler, S | 1 |
| Khosrawi, S; Ramezani, M; Taheri, P | 1 |
| Heimbach, T; Jogiraju, VK; Taft, DR; Toderika, Y | 1 |
| Brucculeri, MJ; Garcia, J | 1 |
| Brahmam, B; Chaudhari, P; Dsouza, L; Lewis, SA | 1 |
| Frascarolo, S; Moutinot, B; Sartori, C | 1 |
| Gheddar, L; Kintz, P; Raul, JS | 1 |
| Caram-Salas, NL; Castelo-Flores, DG; Centurión, D; De la Luz-Cuellar, YE; Granados-Soto, V; Rodríguez-Palma, EJ; Salinas-Abarca, AB | 1 |
| Dutt, R; Kaushik, D; Mittal, V; Pandey, P; Rahman, MH; Singh, S; Sinha, S; Thapa, S; Verma, R | 1 |
| Giannouchos, TV; Gómez-Lumbreras, A; Malone, DC | 1 |
| Bois, FY; Fisher, C; Gardner, I; Jamei, M; Kilford, P; Pan, X; Zhang, M | 1 |
| Boyce, RD; Gómez-Lumbreras, A; Horn, J; Malone, DC; Tan, MS; Villa-Zapata, L | 2 |
| Darwish, AB; El-Hashemy, HA; Mohsen, AM; Salama, A | 1 |
| Knight, EM | 1 |
| Arpa, MD; Cevher, E; Gök, MK; Okur, NÜ; Özgümüş, S | 1 |
44 review(s) available for clonidine and tizanidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Spasticity: therapy of increased reflexes or movement disorder?].
Topics: Baclofen; Clonidine; Combined Modality Therapy; Dantrolene; Diazepam; Glycine; Humans; Locomotion; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Muscles; Phenothiazines; Reflex, Abnormal | 1990 |
Pharmacotherapy of spasticity: some theoretical and practical considerations.
Topics: Baclofen; Benzodiazepines; Clonidine; Dantrolene; Humans; Muscle Spasticity; Parasympatholytics | 1987 |
Spasticity: a review.
Topics: Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Neurotransmitter Agents; Reflex, Stretch; Spinal Cord | 1994 |
Tizanidine and electrophysiologic analysis of spinal control mechanisms in humans with spasticity.
Topics: Clonidine; Electrophysiology; Humans; Muscle Relaxants, Central; Muscle Spasticity; Reflex, Stretch; Spinal Cord | 1994 |
Pharmacokinetics and pharmacodynamics of tizanidine.
Topics: Clonidine; Dose-Response Relationship, Drug; Humans; Muscle Relaxants, Central; Muscle Spasticity | 1994 |
Comparative profile of tizanidine in the management of spasticity.
Topics: Activities of Daily Living; Baclofen; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus | 1994 |
Tizanidine: neuropharmacology and mechanism of action.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Muscle Relaxants, Central; Spinal Cord; Synaptic Transmission | 1994 |
Summary of combined clinical analysis of controlled clinical trials with tizanidine.
Topics: Adult; Aged; Clonidine; Controlled Clinical Trials as Topic; Databases, Factual; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Myoclonus; Spasm | 1994 |
Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders.
Topics: Adrenergic alpha-Agonists; Animals; Brain Diseases; Clinical Trials as Topic; Clonidine; Humans; Muscle Spasticity; Parasympatholytics; Receptors, Adrenergic, alpha-2; Spinal Cord Diseases | 1997 |
[The use of sirdalud in painful muscle tonic syndromes].
Topics: Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Muscular Diseases; Pain; Syndrome | 1997 |
An approach to switching patients from baclofen to tizanidine.
Topics: Baclofen; Clinical Competence; Clonidine; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Spinal Cord Diseases; Spinal Cord Injuries | 1998 |
[Tizanidine-induced toxic hepatitis].
Topics: Aged; Cerebral Infarction; Chemical and Drug Induced Liver Injury; Clonidine; Drug Therapy, Combination; Humans; Male; Muscle Relaxants, Central | 1999 |
Drugs used to treat spasticity.
Topics: Baclofen; Clonidine; Dantrolene; Diazepam; Drug Administration Schedule; Humans; Muscle Relaxants, Central; Muscle Spasticity | 2000 |
Pharmacological interventions for spasticity following spinal cord injury.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Parasympatholytics; Spasm; Spinal Cord Injuries | 2000 |
Alpha adrenergic and serotonergic agents in the treatment of spastic hypertonia.
Topics: Adrenergic alpha-Agonists; Animals; Anticonvulsants; Clonidine; Cyproheptadine; Humans; Muscle Spasticity; Parasympatholytics; Receptors, Adrenergic; Serotonin Antagonists; Spinal Cord; Sympatholytics | 2001 |
[Treatment of spasticity].
Topics: Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Clonidine; Humans; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Quality of Life | 1999 |
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.
Topics: Acetates; Amines; Autoimmune Diseases; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Cannabinoids; Causalgia; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Dystonia; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Mechanoreceptors; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Pain; Physical Therapy Modalities; Receptors, GABA-A; Receptors, GABA-B; Relaxation Therapy; Trigeminal Neuralgia | 2001 |
Anti-spasticity medications.
Topics: Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Parasympatholytics | 2003 |
Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role?
Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; GABA Agonists; Humans; Migraine Disorders; Muscle Relaxants, Central; Neuromuscular Agents; Tension-Type Headache | 2003 |
[Spastic syndrome and main directions of its treatment].
Topics: Anti-Dyskinesia Agents; Botulinum Toxins; Clonidine; Exercise Therapy; Humans; Motor Neuron Disease; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Physical Therapy Modalities; Pyramidal Tracts; Syndrome | 2003 |
Muscle relaxants in the treatment of myofascial face pain. A literature review.
Topics: Antidepressive Agents, Tricyclic; Benzodiazepines; Clonidine; Facial Pain; Humans; Neuromuscular Agents | 2004 |
[Pharmacology and upper limb poststroke spasticity: a review. International Society of Prosthetics and Orthotics].
Topics: Arm; Baclofen; Botulinum Toxins, Type A; Clonidine; Combined Modality Therapy; Dantrolene; Ergonomics; Ethanol; Humans; Injections, Intramuscular; Injections, Spinal; Muscle Denervation; Muscle Spasticity; Neuromuscular Agents; Neuromuscular Blockade; Phenol; Physical Therapy Modalities; Stroke | 2004 |
Preventive migraine therapy: what is new.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Antidepressive Agents, Second-Generation; Antioxidants; Benzimidazoles; Biphenyl Compounds; Botulinum Toxins; Clonidine; Coenzymes; Fructose; Humans; Lisinopril; Migraine Disorders; Neuroprotective Agents; Petasites; Phytotherapy; Piperazines; Tetrazoles; Topiramate; Triazoles; Ubiquinone | 2004 |
Pharmacologic interventions for reducing spasticity in cerebral palsy.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Age Factors; Anti-Infective Agents, Local; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child, Preschool; Clonidine; Dantrolene; Diazepam; Ethanol; Humans; Infant; Injections, Intramuscular; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Phenol; Time Factors | 2005 |
Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Muscle Spasticity; Randomized Controlled Trials as Topic; Spinal Cord Injuries | 2006 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propoxycaine; Randomized Controlled Trials as Topic; Tocainide; Trigeminal Neuralgia | 2006 |
The pharmacological management of spasticity.
Topics: Baclofen; Clonidine; Dantrolene; Humans; Muscle Relaxants, Central; Muscle Spasticity | 2006 |
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.
Topics: Brain Injuries; Clonidine; Disease Progression; Drug Interactions; Female; Humans; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Spasm; Spinal Cord Injuries; Stroke | 2008 |
A clinically relevant review of tizanidine hydrochloride dose relationships to pharmacokinetics, drug safety and effectiveness in healthy subjects and patients.
Topics: Chemistry, Pharmaceutical; Ciprofloxacin; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Fluvoxamine; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Treatment Outcome | 2008 |
Update on tizanidine for muscle spasticity and emerging indications.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Dose-Response Relationship, Drug; Humans; Low Back Pain; Multiple Sclerosis; Muscle Cramp; Muscle Relaxants, Central; Muscle Spasticity; Neck Pain; Spinal Cord Injuries | 2008 |
Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
Topics: Adolescent; Botulinum Toxins, Type A; Cerebral Palsy; Child; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Treatment Outcome | 2010 |
[New therapies for spastic movement disorders].
Topics: Administration, Oral; Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; Injections, Intramuscular; Injections, Spinal; Movement Disorders; Muscle Relaxants, Central; Muscle Spasticity; Parasympatholytics; Physical Therapy Modalities; Tolperisone | 2009 |
Spasticity: revisiting the role and the individual value of several pharmacological treatments.
Topics: Amines; Baclofen; Botulinum Toxins; Calcium Channel Blockers; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Diazepam; Gabapentin; gamma-Aminobutyric Acid; Humans; Muscle Relaxants, Central; Muscle Spasticity; Recovery of Function; Treatment Outcome | 2010 |
Managing spasticity with drugs.
Topics: Administration, Oral; Baclofen; Botulinum Toxins, Type A; Clonidine; Humans; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents | 2010 |
Pharmacologic treatment of spasticity in children.
Topics: Age Factors; Baclofen; Botulinum Toxins; Child; Clonidine; Dantrolene; Diazepam; Humans; Injections, Spinal; Muscle Spasticity; Neuromuscular Agents | 2010 |
Pharmacotherapy of spasticity in children with cerebral palsy.
Topics: Baclofen; Benzodiazepines; Cerebral Palsy; Child; Clonidine; Dantrolene; Humans; Muscle Spasticity; Neuromuscular Blocking Agents | 2011 |
[Pharmacological treatment of spasticity in multiple sclerosis].
Topics: Algorithms; Amines; Baclofen; Botulinum Toxins, Type A; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Double-Blind Method; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Humans; Infusion Pumps, Implantable; Injections, Spinal; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Nerve Block; Neuromuscular Agents; Randomized Controlled Trials as Topic; Spasm; Vigabatrin | 2012 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Analgesics; Anticonvulsants; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propoxycaine; Randomized Controlled Trials as Topic; Tocainide; Trigeminal Neuralgia | 2013 |
Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.
Topics: Amines; Analgesics; Baclofen; Cannabidiol; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Diazepam; Dronabinol; Drug Combinations; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Phenol | 2016 |
Clinical efficacy and safety of eperisone for low back pain: A systematic literature review.
Topics: Chronic Pain; Clonidine; Humans; Low Back Pain; Pain Measurement; Propiophenones; Treatment Outcome | 2016 |
Pharmacological interventions other than botulinum toxin for spasticity after stroke.
Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Randomized Controlled Trials as Topic; Stroke; Tolperisone | 2016 |
A mixed treatment comparison on efficacy and safety of treatments for spasticity caused by multiple sclerosis: a systematic review and network meta-analysis.
Topics: Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Transcutaneous Electric Nerve Stimulation | 2018 |
A Critical Review of the Role of the Cannabinoid Compounds Δ
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Baclofen; Cannabidiol; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol; Drug Approval; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Multiple Sclerosis; Spinal Cord; Treatment Outcome; United States; United States Food and Drug Administration | 2020 |
98 trial(s) available for clonidine and tizanidine
| Article | Year |
|---|---|
[Clinical experiences with a new muscle relaxant (DS 103-282 Sandoz) (author's transl)].
Topics: Adult; Clinical Trials as Topic; Clonidine; Drug Evaluation; Drug Tolerance; Female; Humans; Male; Middle Aged; Movement Disorders; Muscle Spasticity; Sleep Wake Disorders; Xerostomia | 1977 |
Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Depression; Dose-Response Relationship, Drug; Double-Blind Method; Electromyography; Female; Headache; Humans; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Neck Muscles; Placebos | 1992 |
Tizanidine in cranial dystonia.
Topics: Brain Stem; Clonidine; Dystonia; Female; Humans; Male; Meige Syndrome; Middle Aged; Muscle Relaxants, Central; Neurons; Single-Blind Method | 1992 |
Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration.
Topics: Clonidine; Fatty Acids, Nonesterified; Female; Headache; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Osmolar Concentration | 1991 |
[Comparative double-blind study of the effectiveness and tolerance of baclofen, tetrazepam and tizanidine in spastic movement disorders of the lower extremities].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Random Allocation | 1989 |
A double-blind, long-term study of tizanidine ('Sirdalud') in spasticity due to cerebrovascular lesions.
Topics: Adult; Aged; Baclofen; Cerebrovascular Disorders; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity | 1989 |
Multi-centre, double-blind trial of a novel antispastic agent, tizanidine, in spasticity associated with multiple sclerosis.
Topics: Adult; Aged; Baclofen; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity | 1988 |
A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Hemiplegia; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Random Allocation | 1988 |
Tizanidine versus baclofen in the treatment of spasticity in patients with multiple sclerosis.
Topics: Adult; Aged; Baclofen; Brain; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity | 1988 |
Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo.
Topics: Adult; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Heart Rate; Humans; Male; Placebos; Substance-Related Disorders; Surveys and Questionnaires | 1988 |
Tizanidine in the management of trigeminal neuralgia.
Topics: Aged; Analgesics; Carbamazepine; Clinical Trials as Topic; Clonidine; Double-Blind Method; Humans; Middle Aged; Random Allocation; Trigeminal Neuralgia | 1986 |
The treatment of spasticity in multiple sclerosis: a double-blind clinical trial of a new anti-spastic drug tizanidine compared with baclofen.
Topics: Adult; Aged; Baclofen; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity | 1987 |
Treatment of spasticity with tizanidine in multiple sclerosis.
Topics: Adolescent; Adult; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Muscle Tonus; Random Allocation; Reflex, Stretch | 1987 |
Spasmodic torticollis: treatment with Tizanidine.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Electromyography; Female; Humans; Male; Middle Aged; Torticollis | 1984 |
A new skeletal muscle relaxant (DS 103-282) compared to diazepam in the treatment of muscle spasm of local origin.
Topics: Adult; Aged; Back Pain; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity | 1981 |
Tizanidine (DS 103-282) in the treatment of acute paravertebral muscle spasm: a controlled trial comparing tizanidine and diazepam.
Topics: Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Random Allocation; Spasm; Spinal Diseases; Time Factors | 1981 |
Tizanidine in the treatment of spasticity.
Topics: Adult; Baclofen; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Spasticity; Time Factors | 1982 |
A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis.
Topics: Adult; Aged; Baclofen; Chronic Disease; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity | 1981 |
Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Electromyography; Female; Gait; Humans; Locomotion; Male; Middle Aged; Movement; Multiple Sclerosis; Muscle Contraction; Muscle Spasticity; Paralysis; Paraplegia; Parasympatholytics | 1982 |
The assessment of drug treatment of spastic gait.
Topics: Aged; Baclofen; Clinical Trials as Topic; Clonidine; Female; Gait; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity | 1981 |
The metabolic effects of oral tizanidine in healthy volunteers.
Topics: Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Energy Metabolism; Humans; Male; Oxygen Consumption; Pilot Projects | 1995 |
Selective depression of medium-latency leg and foot muscle responses to stretch by an alpha 2-agonist in humans.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Electromyography; Female; Foot; Humans; Leg; Male; Middle Aged; Muscle, Skeletal; Physical Stimulation; Posture; Reaction Time; Reflex, Stretch; Rotation | 1995 |
[Effects of oral alpha 2 adrenergic agonists, clonidine and tizanidine, on tetracaine spinal anesthesia].
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Anesthesia, Spinal; Clonidine; Female; Humans; Hysterectomy, Vaginal; Middle Aged; Preanesthetic Medication; Tetracaine | 1995 |
[The efficacy of sirdalud in the drug therapy of pain in the spine].
Topics: Acute Disease; Adult; Aged; Analgesics; Back Pain; Chronic Disease; Clonidine; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Pain Measurement | 1994 |
Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache.
Topics: Clonidine; Electric Stimulation; Humans; Muscle Contraction; Muscle Relaxants, Central; Temporal Muscle; Tension-Type Headache | 1994 |
Correlations between dose, plasma concentrations, and antispastic action of tizanidine (Sirdalud).
Topics: Adult; Clonidine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Spasticity; Parasympatholytics; Placebos; Treatment Outcome | 1994 |
Tizanidine treatment of spasticity caused by multiple sclerosis: results of a double-blind, placebo-controlled trial. US Tizanidine Study Group.
Topics: Adolescent; Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Myoclonus; Patient Satisfaction; Spasm | 1994 |
Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American Tizanidine Study Group.
Topics: Activities of Daily Living; Administration, Oral; Adolescent; Adult; Aged; Clonidine; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Spasm; Spinal Cord Injuries | 1994 |
A double-blind, placebo-controlled trial of tizanidine in the treatment of spasticity caused by multiple sclerosis. United Kingdom Tizanidine Trial Group.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Pain; Prospective Studies; Reflex, Stretch; Spasm | 1994 |
A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Animals; Cats; Clonidine; Double-Blind Method; Drug Resistance; Electric Stimulation; Humans; Middle Aged; Pain Measurement; Trigeminal Nerve; Trigeminal Neuralgia | 1993 |
The sedative and sympatholytic effects of oral tizanidine in healthy volunteers.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Flicker Fusion; Growth Hormone; Humans; Male; Muscle Relaxants, Central; Norepinephrine; Salivation | 1996 |
[Tizanidine for preanesthetic medication].
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Anesthesia, General; Clonidine; Elective Surgical Procedures; Female; Hemodynamics; Humans; Male; Midazolam; Middle Aged; Preanesthetic Medication | 1996 |
[The treatment of the phantom pain syndrome with tizanidine].
Topics: Adult; Aged; Analgesics; Chronic Disease; Clonidine; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain Measurement; Phantom Limb; Statistics, Nonparametric; Syndrome | 1997 |
Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis.
Topics: Adrenergic alpha-Agonists; Canada; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Multiple Sclerosis; Muscle Contraction; Muscle Relaxants, Central; Severity of Illness Index; Treatment Outcome; United States | 1997 |
A controlled pharmacokinetic evaluation of tizanidine and baclofen at steady state.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Baclofen; Biotransformation; Clonidine; Drug Interactions; Half-Life; Humans; Male; Muscle Relaxants, Central | 1999 |
[The use of sirdalud in the treatment of spasticity in infantile cerebral palsy].
Topics: Adolescent; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Male; Muscle Spasticity; Treatment Outcome | 1999 |
[The use of sirdalud in cerebral palsy in children].
Topics: Adolescent; Cerebral Palsy; Child; Clonidine; Dose-Response Relationship, Drug; Electromyography; Female; H-Reflex; Humans; Male; Muscle Relaxants, Central; Time Factors | 1999 |
Modified-release formulation of tizanidine in chronic tension-type headache.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Chronic Disease; Clonidine; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain Measurement; Tension-Type Headache | 2000 |
An open-label dose-titration study of the efficacy and tolerability of tizanidine hydrochloride tablets in the prophylaxis of chronic daily headache.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Dose-Response Relationship, Drug; Female; Headache Disorders; Humans; Male; Medical Records; Middle Aged; Pilot Projects; Prospective Studies; Treatment Outcome | 2001 |
Open-label dose-titration safety and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with chronic stroke.
Topics: Clonidine; Dose-Response Relationship, Drug; Female; Hand Strength; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Pain; Quality of Life; Severity of Illness Index; Stroke; Treatment Outcome | 2001 |
Prospective assessment of tizanidine for spasticity due to acquired brain injury.
Topics: Administration, Oral; Adult; Aged; Brain Injuries; Clonidine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscle Hypertonia; Muscle Relaxants, Central; Muscle Spasticity; Prospective Studies; Reflex, Abnormal; Severity of Illness Index; Sleep Stages; Treatment Outcome | 2001 |
Oral tizanidine, an alpha2-adrenoceptor agonist, reduces the minimum alveolar concentration of sevoflurane in human adults.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Clonidine; Drug Interactions; Female; Humans; Male; Methyl Ethers; Middle Aged; Preanesthetic Medication; Pulmonary Alveoli; Sevoflurane | 2002 |
Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Chronic Disease; Clonidine; Double-Blind Method; Female; Headache Disorders; Humans; Male; Middle Aged; Treatment Outcome | 2002 |
Cost-effectiveness comparison of tizanidine and baclofen in the management of spasticity.
Topics: Baclofen; Clonidine; Cost-Benefit Analysis; Humans; Muscle Relaxants, Central; Muscle Spasticity; United Kingdom | 2002 |
Modulation of the transmission in group II heteronymous pathways by tizanidine in spastic hemiplegic patients.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Female; Hemiplegia; Humans; Leg; Male; Middle Aged; Motor Neurons; Neural Conduction; Placebos; Stroke | 2004 |
Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Clonidine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Incompatibility; Drug Interactions; Fluvoxamine; Half-Life; Humans; Male; Muscle Relaxants, Central; Probability; Risk Assessment | 2004 |
Effect of oral tizanidine on local-anesthetic infiltration pain during epidural catheterization.
Topics: Administration, Oral; Adult; Aged; Analgesics; Anesthesia, Epidural; Anesthetics, Local; Catheterization; Catheters, Indwelling; Clonidine; Female; Humans; Male; Middle Aged; Pain; Preanesthetic Medication | 2004 |
[Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Child; Child, Preschool; Clonidine; Disabled Children; Drug Administration Schedule; Female; Humans; Infant; Male; Muscle Hypertonia; Pain; Quadriplegia; Sleep Wake Disorders; Treatment Outcome | 2004 |
Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.
Topics: Adult; Anti-Infective Agents; Area Under Curve; Blood Pressure; Caffeine; Chromatography, High Pressure Liquid; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Half-Life; Heart Rate; Humans; Muscle Relaxants, Central; Phosphodiesterase Inhibitors | 2004 |
Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.
Topics: Acute Disease; Adrenergic alpha-Agonists; Adult; Clonidine; Colchicine; Double-Blind Method; Female; Humans; Low Back Pain; Male; Middle Aged; Muscle Relaxants, Central; Psychomotor Performance; Treatment Outcome | 2005 |
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Area Under Curve; Caffeine; Clonidine; Contraceptives, Oral, Combined; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Ethinyl Estradiol; Female; Half-Life; Humans; Norpregnenes; Theophylline | 2005 |
Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life.
Topics: Adult; Amitriptyline; Analgesics; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Headache; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Pain Measurement; Quality of Life | 2006 |
Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine.
Topics: Adult; Anti-Bacterial Agents; Blood Pressure; Caffeine; Clonidine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Drug Interactions; Enzyme Induction; Female; Heart Rate; Humans; Male; Rifampin | 2006 |
Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Clonidine; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP1A2 Inhibitors; Double-Blind Method; Drug Interactions; Humans; Lactones; Male; Sulfones | 2006 |
Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers.
Topics: Adolescent; Adult; Capsules; Clonidine; Cognition; Cross-Over Studies; Disorders of Excessive Somnolence; Female; Follow-Up Studies; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Muscle Relaxants, Central; Reference Values; Tablets | 2006 |
Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.
Topics: Adult; Anticoagulants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Clonidine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Food-Drug Interactions; Half-Life; Humans; Male; Midazolam; Stereoisomerism; Vaccinium macrocarpon; Warfarin | 2007 |
Efficacy of neuroprotectors in patients with tension headaches.
Topics: Acupressure; Adolescent; Adult; Aged; Analgesics; Clonidine; Combined Modality Therapy; Drug Therapy, Combination; Electromyography; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Neuroprotective Agents; Picolines; Tension-Type Headache; Treatment Outcome | 2007 |
Relative bioavailability of tizanidine 4-mg capsule and tablet formulations after a standardized high-fat meal: a single-dose, randomized, open-label, crossover study in healthy subjects.
Topics: Adult; Asthenia; Biological Availability; Capsules; Clonidine; Cross-Over Studies; Dietary Fats; Dosage Forms; Female; Food-Drug Interactions; Humans; Male; Muscle Relaxants, Central; Tablets | 2007 |
Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study.
Topics: Adolescent; Adult; Clonidine; Edema; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Molar, Third; Muscle Relaxants, Central; Pain, Postoperative; Sex Distribution; Trismus | 2007 |
Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation.
Topics: Adult; Algorithms; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cell Culture Techniques; Clonidine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Half-Life; Humans; Kinetics; Male; Microsomes, Liver; Muscle Relaxants, Central; ortho-Aminobenzoates; Protein Binding; Serum Albumin | 2007 |
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Half-Life; Humans; Male; Sex Factors; Sleep Stages; Smoking; Theophylline | 2008 |
Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo.
Topics: Adult; Area Under Curve; Caffeine; Celecoxib; Clonidine; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Half-Life; Humans; In Vitro Techniques; Male; Microsomes, Liver; Pyrazoles; Sulfonamides | 2008 |
[Protocol for tizanidine use in infantile cerebral palsy].
Topics: Cerebral Palsy; Child; Child, Preschool; Clonidine; Drug Administration Schedule; Female; Humans; Infant; Male; Parasympatholytics | 2008 |
Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm.
Topics: Acute Disease; Administration, Oral; Adult; Analgesics; Clonidine; Colchicine; Female; Humans; India; Low Back Pain; Male; Middle Aged; Pain Measurement; Single-Blind Method; Spasm | 2008 |
Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Botulinum Toxins; Clonidine; Double-Blind Method; Female; Fingers; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Neuromuscular Agents; Treatment Outcome; Upper Extremity; Wrist; Young Adult | 2009 |
Botulinum toxin type A with oral baclofen versus oral tizanidine: a nonrandomized pilot comparison in patients with cerebral palsy and spastic equinus foot deformity.
Topics: Administration, Oral; Adolescent; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Chi-Square Distribution; Child; Child, Preschool; Clonidine; Drug Therapy, Combination; Equinus Deformity; Female; Humans; Male; Muscle Relaxants, Central; Neuromuscular Agents; Pilot Projects; Treatment Outcome | 2008 |
Relative bioavailability of tizanidine hydrochloride capsule formulation compared with capsule contents administered in applesauce: a single-dose, open-label, randomized, two-way, crossover study in fasted healthy adult subjects.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Area Under Curve; Asthenia; Biological Availability; Blood Pressure; Capsules; Clonidine; Cross-Over Studies; Dose-Response Relationship, Drug; Fasting; Female; Food; Food-Drug Interactions; Half-Life; Humans; Male; Malus; Middle Aged; Young Adult | 2008 |
Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.
Topics: Activities of Daily Living; Acute Disease; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Diclofenac; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Therapy; Drug Therapy, Combination; Female; Humans; Low Back Pain; Male; Middle Aged; Mobility Limitation; Movement; Outcome Assessment, Health Care; Pain Measurement; Pain Threshold; Patient Satisfaction; Placebo Effect; Range of Motion, Articular; Treatment Outcome; Young Adult | 2009 |
Effect of cold application and tizanidine on clonus: clinical and electrophysiological assessment.
Topics: Adult; Anticonvulsants; Clonidine; Cryotherapy; Electromyography; Female; H-Reflex; Humans; Male; Middle Aged; Myoclonus; Neural Conduction; Severity of Illness Index; Young Adult | 2009 |
Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Chromatography, High Pressure Liquid; Clonidine; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Half-Life; Humans; Male; Mexiletine; Sleep Stages; Tandem Mass Spectrometry; Xerostomia | 2010 |
Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.
Topics: Administration, Sublingual; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Clonidine; Cross-Over Studies; Disorders of Excessive Somnolence; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Matched-Pair Analysis; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Patient Dropouts; Severity of Illness Index; Time Factors; Young Adult | 2010 |
[The use of sirdalud MR in patients with multiple sclerosis].
Topics: Adult; Clonidine; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Weakness; Severity of Illness Index; Sleep Wake Disorders; Treatment Outcome; Young Adult | 2010 |
Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride.
Topics: Adult; Calorimetry, Differential Scanning; Chemical Phenomena; Clonidine; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Excipients; Gastrointestinal Agents; Gastrointestinal Transit; Humans; Hypromellose Derivatives; Kinetics; Male; Methylcellulose; Parasympatholytics; Sodium Bicarbonate; Solubility; Stearic Acids; Tablets; Young Adult | 2011 |
Doxazosin versus tizanidine for treatment of dysfunctional voiding in children: a prospective randomized open-labeled trial.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Anorexia; Child; Child, Preschool; Clonidine; Doxazosin; Female; Humans; Male; Nocturnal Enuresis; Pain; Urinary Incontinence; Urination Disorders | 2012 |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.
Topics: Adult; Aged; Amitriptyline; Clonidine; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Orphenadrine; Pilot Projects; Propiophenones; Severity of Illness Index; Tinnitus; Treatment Outcome | 2012 |
Effect of adding cervical facet joint injections in a multimodal treatment program for long-standing cervical myofascial pain syndrome with referral pain patterns of cervical facet joint syndrome.
Topics: Acetaminophen; Anesthetics, General; Chronic Pain; Clonidine; Codeine; Combined Modality Therapy; Double-Blind Method; Exercise Therapy; Female; Follow-Up Studies; Humans; Ibuprofen; Injections; Male; Middle Aged; Myofascial Pain Syndromes; Neck Pain; Pain Measurement; Prospective Studies; Zygapophyseal Joint | 2012 |
Eperisone versus tizanidine for treatment of chronic low back pain.
Topics: Analysis of Variance; Chronic Pain; Clonidine; Drug Therapy, Combination; Female; Humans; Italy; Low Back Pain; Male; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Pain Management; Pain Measurement; Propiophenones; Prospective Studies; Tramadol | 2012 |
The effect of robot-assisted locomotor training on walking speed.
Topics: Clonidine; Humans; Motor Activity; Recovery of Function; Robotics; Time Factors; Walking | 2012 |
Pharmacokinetic comparison of two 4 mg tablet formulations of tizanidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Chemistry, Pharmaceutical; Clonidine; Cross-Over Studies; Humans; Male; Single-Blind Method; Tablets | 2013 |
Pharmacokinetic characterization of tizanidine nasal spray, a novel intranasal delivery method for the treatment of skeletal muscle spasm.
Topics: Administration, Intranasal; Adult; Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Clonidine; Cross-Over Studies; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle, Skeletal; Spasm; Tandem Mass Spectrometry; Young Adult | 2013 |
Amitriptyline versus tizanidine in the management of tension-type headache in Nepal.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Analgesics; Clonidine; Female; Humans; Male; Middle Aged; Nepal; Tension-Type Headache; Young Adult | 2013 |
Effect of antispastic drugs on motor reflexes and voluntary muscle contraction in incomplete spinal cord injury.
Topics: Adult; Baclofen; Clonidine; Cross-Over Studies; Double-Blind Method; Electromyography; Humans; Isometric Contraction; Lower Extremity; Male; Middle Aged; Muscle Relaxants, Central; Muscle Strength; Pilot Projects; Reflex, Stretch; Spinal Cord Injuries; Torque | 2014 |
Chitosan lactate wafer as a platform for the buccal delivery of tizanidine HCl: in vitro and in vivo performance.
Topics: Adhesiveness; Administration, Buccal; Adult; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Chitosan; Clonidine; Cross-Linking Reagents; Cross-Over Studies; Delayed-Action Preparations; Drug Carriers; Half-Life; Humans; Lactates; Male; Metabolic Clearance Rate; Neuromuscular Agents; Polyphosphates; Solubility; Tablets; Technology, Pharmaceutical | 2014 |
Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Clonidine; Double-Blind Method; Facial Pain; Female; Humans; Ibuprofen; Male; Middle Aged; Muscle Relaxants, Central; Pain Measurement; Patient Education as Topic; Placebos; Self Care; Severity of Illness Index; Sleep; Temporomandibular Joint Dysfunction Syndrome; Treatment Outcome; Young Adult | 2014 |
Central noradrenergic mechanisms and the acute stress response during painful stimulation.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Adult; Brain; Clonidine; Double-Blind Method; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Galvanic Skin Response; Humans; Male; Middle Aged; Pain; Pain Measurement; Pupil; Young Adult | 2014 |
Interventions to Reduce Spasticity and Improve Function in People With Chronic Incomplete Spinal Cord Injury: Distinctions Revealed by Different Analytical Methods.
Topics: Analysis of Variance; Cervical Vertebrae; Chronic Disease; Clonidine; Data Interpretation, Statistical; Exercise Test; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Outpatients; Severity of Illness Index; Spinal Cord Injuries; Thoracic Vertebrae; Treatment Outcome; Walking | 2015 |
Variability in responsiveness to interventions in people with spinal cord injury: Do some respond better than others?
Topics: Ankle Joint; Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Spinal Cord Injuries; Treatment Outcome; Walking | 2014 |
Classifying and predicting endurance outcomes of α2-adrenergic agonist intervention in spinal cord injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Humans; Physical Endurance; Recovery of Function; Spinal Cord Injuries; Treatment Outcome; Walking | 2014 |
[Treatment of myofascial pain syndrome].
Topics: Adult; Analgesics; Clonidine; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Myofascial Pain Syndromes; Reflexotherapy | 2014 |
[The use of tizanidine in combined treatment of arm poststroke spasticity].
Topics: Anticonvulsants; Arm; Botulinum Toxins, Type A; Clonidine; Female; Humans; Male; Muscle Spasticity; Neuromuscular Agents; Stroke; Stroke Rehabilitation | 2014 |
[A role of treatment of autonomic syndrome in patients with tension-type headache].
Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Autonomic Nervous System; Autonomic Nervous System Diseases; Clonidine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Ibuprofen; Pain Measurement; Parasympatholytics; Surveys and Questionnaires; Syndrome; Tension-Type Headache; Treatment Outcome | 2015 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herniorrhaphy; Humans; Male; Middle Aged; Pain Management; Pain Measurement; Pain, Postoperative; Prospective Studies | 2016 |
Influence of Previous Failed Antispasticity Therapy on the Efficacy and Tolerability of THC:CBD Oromucosal Spray for Multiple Sclerosis Spasticity.
Topics: Adult; Baclofen; Cannabidiol; Clonidine; Dronabinol; Drug Combinations; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Parasympatholytics; Plant Extracts | 2016 |
Effect of Extracorporeal Shock Wave Therapy on Lower Limb Spasticity in Stroke Patients.
Topics: Adult; Aged; Clonidine; Extracorporeal Shockwave Therapy; Female; Humans; Iran; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Prospective Studies; Stroke; Stroke Rehabilitation; Treatment Outcome | 2017 |
Ultrasound-guided bilateral superficial cervical block and preemptive single-dose oral tizanidine for post-thyroidectomy pain: a randomized-controlled double-blind study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind Method; Female; Fentanyl; Humans; Male; Middle Aged; Nerve Block; Pain, Postoperative; Propofol; Thyroidectomy | 2018 |
Effect of Intrathecal Baclofen on Pain and Quality of Life in Poststroke Spasticity.
Topics: Administration, Oral; Aged; Baclofen; Benzodiazepines; Clonidine; Dantrolene; Female; Humans; Infusions, Spinal; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Pain; Pain Measurement; Patient Satisfaction; Physical Therapy Modalities; Quality of Life; Severity of Illness Index; Stroke; Stroke Rehabilitation; Treatment Outcome | 2018 |
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Baclofen; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ibuprofen; Low Back Pain; Male; Muscle Relaxants, Central; Oxazolidinones; Treatment Outcome | 2019 |
Extracorporeal Shock Wave Therapy Combined With Oral Medication and Exercise for Chronic Low Back Pain: A Randomized Controlled Trial.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Combined Modality Therapy; Disability Evaluation; Exercise Therapy; Extracorporeal Shockwave Therapy; Female; Humans; Low Back Pain; Male; Meloxicam; Middle Aged; Pain Measurement | 2021 |
247 other study(ies) available for clonidine and tizanidine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
QSAR study of imidazoline antihypertensive drugs.
Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Topics: Amidohydrolases; Carbamates; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Piperazines; Stereoisomerism; Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
[Long-term treatment with an imidazoline derivative (DS 103--282) (author's transl)].
Topics: Arm; Clonidine; Female; Humans; Leg; Male; Multiple Sclerosis; Muscle Spasticity; Paralysis; Urination Disorders | 1979 |
The effect of centrally acting myorelaxants on NMDA receptor-mediated synaptic transmission in the immature rat spinal cord in vitro.
Topics: Animals; Baclofen; Clonidine; Diazepam; In Vitro Techniques; Muscle Relaxants, Central; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission; Tetrodotoxin | 1992 |
Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors.
Topics: Animals; Binding, Competitive; Clonidine; Imidazoline Receptors; Kidney; Kinetics; Male; Membranes; Muscle Relaxants, Central; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Drug; Tritium | 1992 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
The pharmacological properties of CS-722, a newly synthesized centrally acting muscle relaxant.
Topics: Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Isoxazoles; Male; Morpholines; Motor Neurons, Gamma; Muscle Relaxants, Central; Muscle Rigidity; Parasympatholytics; Rats; Rats, Wistar; Sleep; Spinal Cord; Thiopental | 1992 |
Antinociceptive effects of tizanidine, diazepam and eperisone in isolated spinal cord-tail preparations of newborn rat.
Topics: Analgesics; Animals; Animals, Newborn; Clonidine; Diazepam; Evoked Potentials; In Vitro Techniques; Muscle Relaxants, Central; Physical Stimulation; Propiophenones; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Spinal Nerve Roots; Tail; Time Factors | 1992 |
Flexor reflex for assessment of common interneurone activity in spasticity.
Topics: Adult; Aged; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Cerebrovascular Disorders; Clonidine; Electroacupuncture; Electromyography; Female; Hemiplegia; Humans; Interneurons; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Reaction Time; Reflex | 1992 |
Development of a simple spasticity quantification method: effects of tizanidine on spasticity in patients with sequelae of cerebrovascular disease.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clonidine; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Seizures | 1992 |
[Effects of tizanidine, a central muscle relaxant, upon spinal reflexes].
Topics: Animals; Cats; Clonidine; Muscle Relaxants, Central; Reflex; Spinal Cord | 1992 |
Differences in alpha 1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery.
Topics: Animals; Aorta, Thoracic; Clonidine; Dioxanes; Iliac Artery; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Receptors, Adrenergic, alpha; Tissue Distribution; Vasoconstriction | 1991 |
Tizanidine-induced depression of polysynaptic cutaneous reflexes in nonanesthetized monkeys is mediated by an alpha 2-adrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Electric Stimulation; Electromyography; Macaca; Receptors, Adrenergic, alpha; Reflex; Skin; Synapses; Yohimbine | 1991 |
Noradrenergic mechanisms involved in muscle relaxation: significance for the treatment of spasticity.
Topics: Animals; Clonidine; Humans; Locus Coeruleus; Muscle Relaxants, Central; Muscle Spasticity; Neural Inhibition; Neural Pathways; Norepinephrine; Spinal Cord | 1991 |
Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; In Vitro Techniques; Male; Parasympatholytics; Piperoxan; Prazosin; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Veratridine; Yohimbine | 1991 |
Phenytoin-tizanidine interaction.
Topics: Anticonvulsants; Biotransformation; Clonidine; Drug Interactions; Drug Monitoring; Female; Humans; Middle Aged; Phenytoin; Reflex Sympathetic Dystrophy; Seizures | 1991 |
Concomitant depression of locus coeruleus neurons and of flexor reflexes by an alpha 2-adrenergic agonist in rats: a possible mechanism for an alpha 2-mediated muscle relaxation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Locus Coeruleus; Male; Muscle Contraction; Muscle Relaxation; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Spinal alpha 1- and alpha 2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.
Topics: Animals; Clonidine; Clorgyline; Levodopa; Male; Motor Neurons; Piperoxan; Prazosin; Premedication; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex, Monosynaptic; Spinal Cord; Synaptic Transmission | 1990 |
Effect of intrathecal tizanidine on antinociception and blood pressure in the rat.
Topics: Analgesics; Animals; Blood Pressure; Clonidine; Injections, Spinal; Male; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Yohimbine | 1990 |
[The effect of muscle relaxants on the function of the vestibulo-ocular reflex arc].
Topics: Adult; Baclofen; Clonidine; Female; Humans; Male; Muscle Relaxants, Central; Reflex, Vestibulo-Ocular | 1990 |
Antagonists of adenosine and alpha-2-adrenoceptors reverse the anticonvulsant effects of tizanidine in DBA/2 mice.
Topics: Adenosine; Adrenergic alpha-Antagonists; Aminophylline; Animals; Anticonvulsants; Clonidine; Habituation, Psychophysiologic; Methysergide; Mice; Mice, Inbred DBA; Piperoxan; Yohimbine | 1989 |
Pharmacodynamics and pharmacokinetics of the oral antispastic agent tizanidine in patients with spinal cord injury.
Topics: Administration, Oral; Adult; Blood Pressure; Clonidine; Drug Evaluation; Heart Rate; Humans; Male; Middle Aged; Muscle Spasticity; Muscles; Paralysis; Parasympatholytics; Spinal Cord Injuries | 1989 |
Effects of tizanidine, eperisone and afloqualone on feline dorsal horn neuronal responses to peripheral cutaneous noxious and innocuous stimuli.
Topics: Air; Analgesics; Animals; Cats; Clonidine; Hot Temperature; Injections, Intravenous; Iontophoresis; Muscle Relaxants, Central; Neurons; Peripheral Nerves; Propiophenones; Quinazolines; Skin; Spinal Cord | 1989 |
Biological fate of sirdalud in animals and man.
Topics: Administration, Oral; Adsorption; Animals; Biotransformation; Carbon Radioisotopes; Clonidine; Dogs; Feces; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Mice; Muscle Relaxants, Central; Rats; Rats, Inbred Strains | 1989 |
Differential effects of clonidine analogs on food intake in rabbits and monkeys.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Female; Macaca; Male; Rabbits; Sodium Chloride | 1989 |
Tizanidine vs. baclofen in the treatment of spasticity in patients with multiple sclerosis.
Topics: Baclofen; Clonidine; Drug Tolerance; Humans; Multiple Sclerosis; Muscle Spasticity | 1989 |
Antinociceptive activity induced by tizanidine and alpha 2-adrenoreceptors.
Topics: Analgesics; Animals; Biogenic Amines; Clonidine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Neurons; Neurotoxins; Reaction Time; Receptors, Adrenergic, alpha | 1987 |
Comparison of alpha-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse.
Topics: Acetates; Adrenergic alpha-Antagonists; Analgesics; Animals; Catecholamines; Clonidine; Male; Mice; Naloxone; Pain; Psychomotor Performance; Reaction Time; Receptors, Adrenergic, alpha; Serotonin | 1986 |
The adrenergic agonist tizanidine has differential effects on flexor reflexes of intact and spinalized rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Electromyography; Muscle Contraction; Prazosin; Reaction Time; Reflex; Spinal Cord; Yohimbine | 1987 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal; Male; Midazolam; Muscle Contraction; Muscle Relaxation; Parasympatholytics; Rats; Rats, Mutant Strains; Reflex, Monosynaptic; Time Factors | 1989 |
Some pharmacological effects of tizanidine on smooth muscle organs and alpha 2-adrenoceptor.
Topics: Animals; Atropine; Binding, Competitive; Clonidine; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Relaxants, Central; Muscle, Smooth; Pupil; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 1985 |
Selective inhibition of responses of feline dorsal horn neurones to noxious cutaneous stimuli by tizanidine (DS103-282) and noradrenaline: involvement of alpha 2-adrenoceptors.
Topics: Animals; Cats; Clonidine; Female; Male; Neurons, Afferent; Norepinephrine; Pain; Receptors, Adrenergic, alpha; Sensation; Skin; Spinal Cord; Yohimbine | 1985 |
Inhibition of small intestine motility by cromakalim (BRL 34915).
Topics: Animals; Benzopyrans; Clonidine; Cromakalim; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestine, Small; Loperamide; Male; Mice; Peristalsis; Potassium Channels; Pyrroles | 1988 |
Effects of tizanidine (DS 103-282) on dorsal horn convergent neurones in the rat.
Topics: Action Potentials; Afferent Pathways; Animals; Clonidine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Muscle Relaxants, Central; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
Tizanidine versus baclofen in the treatment of spasticity in multiple sclerosis patients.
Topics: Adult; Aged; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Muscles | 1988 |
Pharmacokinetics of orally administered tizanidine in healthy volunteers.
Topics: Administration, Oral; Adult; Carbon Radioisotopes; Clonidine; Humans; Male; Middle Aged; Models, Biological; Muscle Relaxants, Central | 1987 |
[Long-term treatment of spasticity with tisanidine (sirdulad) in 2 cases of multiple sclerosis].
Topics: Clonidine; Female; Humans; Leg; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Time Factors | 1987 |
Effects of tizanidine, a centrally acting muscle relaxant, on motor systems.
Topics: Animals; Cerebral Cortex; Chlorpromazine; Clonidine; Decerebrate State; Diazepam; Male; Membranes; Motor Neurons; Muscle Relaxants, Central; Neuromuscular Junction; Neurons, Afferent; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1986 |
Effect of tizanidine on body temperature in the mouse.
Topics: Animals; Body Temperature; Clonidine; Male; Mice; Mice, Inbred Strains; Yohimbine | 1986 |
Substantia nigra and entopeduncular nucleus: supraspinal sites of the muscle relaxant action of tizanidine.
Topics: Animals; Basal Ganglia; Clonidine; Electromyography; Muscle Relaxants, Central; Muscle Tonus; Rats; Rats, Inbred Strains; Substantia Nigra; Yohimbine | 1986 |
Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Male; Mice; Morphine; Motor Skills; Naloxone; Pain Measurement; Sleep | 1986 |
Neuropharmacological investigations in the stiff-man syndrome.
Topics: Adrenergic Fibers; Central Nervous System Diseases; Clonidine; Diazepam; Female; Humans; Methamphetamine; Muscle Rigidity; Reflex, Abnormal; Reserpine; Syndrome | 1986 |
Reduction of centrally-stimulated gastric acid secretion by tizanidine, a new imidazoline derivative, in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Bethanechol Compounds; Clonidine; Deoxyglucose; Electric Stimulation; Gastric Acid; Male; Muscle Relaxants, Central; Phentolamine; Rats; Rats, Inbred Strains; Thyrotropin-Releasing Hormone | 1985 |
Involvement of spinal and supraspinal structures in tizanidine-induced antinociceptive action.
Topics: Animals; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Reaction Time; Spinal Cord | 1986 |
Influence of clonidine and a new related imidazoline derivative (tizanidine) on rat gastric mucosa.
Topics: Animals; Clonidine; Gastric Acid; Gastric Mucosa; Glycoproteins; Indomethacin; Male; Muscle Relaxants, Central; Rats; Rats, Inbred Strains | 1986 |
Electrophysiological analysis of the mode of action of muscle relaxants in spasticity.
Topics: Baclofen; Clonidine; Diazepam; Electrophysiology; Ethanolamines; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity | 1985 |
Antinociceptive action of tizanidine in mice and rats.
Topics: Analgesics; Animals; Behavior, Animal; Clonidine; Electric Stimulation; Male; Mice; Mice, Inbred Strains; Motor Skills; Muscle Relaxants, Central; Naloxone; Rats; Rats, Inbred Strains | 1985 |
Tizanidine (DS103-282), a centrally acting muscle relaxant, selectively depresses excitation of feline dorsal horn neurones to noxious peripheral stimuli by an action at alpha 2-adrenoceptors.
Topics: Animals; Binding, Competitive; Brain; Cats; Clonidine; Iontophoresis; Muscle Relaxants, Central; Norepinephrine; Pain; Receptors, Adrenergic, alpha; Spinal Cord | 1984 |
Analysis of gait and isokinetic movements for evaluation of antispastic drugs or physical therapies.
Topics: Cerebral Palsy; Clonidine; Electromyography; Gait; Humans; Motor Neurons; Muscle Contraction; Muscle Relaxants, Central; Muscle Spasticity; Muscle Spindles; Muscles; Paralysis; Physical Therapy Modalities; Reflex, Stretch | 1983 |
The spasmolytic properties of 5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1,3-benzothiadiazole hydrochloride (DS 103-282): a pilot study.
Topics: Adult; Aged; Blood Pressure; Clonidine; Female; Humans; Male; Middle Aged; Parasympatholytics; Pilot Projects; Pulse; Spasm; Spinal Cord Diseases | 1980 |
Selective depression of synaptic transmission of spinal neurones in the cat by a new centrally acting muscle relaxant, 5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiodazole (DS103-282).
Topics: Amino Acids; Animals; Baclofen; Cats; Clonidine; Female; Male; Muscle Relaxants, Central; Neurons; Reflex; Spinal Cord; Synapses; Synaptic Transmission | 1982 |
Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.
Topics: Animals; Aorta, Thoracic; Clonidine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Muscle, Smooth, Vascular; Rabbits; Rats; Receptors, Adrenergic, alpha; Vas Deferens | 1984 |
Anticonvulsant actions of DS 103-282. Pharmacological studies in rodents and the baboon, Papio papio.
Topics: Acoustic Stimulation; Administration, Oral; Animals; Anticonvulsants; Aspartic Acid; Clonidine; Electroencephalography; Female; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Papio; Photic Stimulation; Species Specificity | 1984 |
Action of tizanidine on responses of forearm flexors and extensors to torque disturbances.
Topics: Adult; Blood Pressure; Clonidine; Electromyography; Female; Forearm; Humans; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle Tonus; Muscles; Reflex, Stretch; Spinal Cord | 1984 |
Tizanidine--initial pharmacokinetic studies in patients with spasticity.
Topics: Adult; Clonidine; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Time Factors | 1983 |
The drug treatment of spasticity.
Topics: Baclofen; Clonidine; Dantrolene; Diazepam; Humans; Muscle Spasticity; Parasympatholytics | 1983 |
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats].
Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Acid; Male; Muscle Relaxants, Central; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine.
Topics: Adult; Brain Stem; Clomipramine; Clonidine; Diazepam; Electromyography; Female; Humans; Muscle Rigidity; Muscular Diseases; Physical Stimulation; Reflex, Abnormal; Spasm; Syndrome | 1984 |
Selective antinociceptive effects of tizanidine (DS 103-282), a centrally acting muscle relaxant, on dorsal horn neurones in the feline spinal cord.
Topics: Amino Acids; Analgesics; Animals; Baclofen; Cats; Clonidine; Electric Stimulation; Female; Injections, Intravenous; Iontophoresis; Male; Muscle Relaxants, Central; Naloxone; Neurons; Norepinephrine; Spinal Cord | 1984 |
Spinal interneurone depression by DS103-282.
Topics: Amino Acids; Animals; Cats; Clonidine; Depression, Chemical; Electric Stimulation; Interneurons; Spinal Cord | 1983 |
Muscle restraint in speed controlled voluntary and passive movements.
Topics: Clonidine; Electromyography; Humans; Knee; Leg; Movement; Muscle Contraction; Muscles; Paresis; Reflex, Stretch | 1982 |
The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (DS 103-282), a novel myotonolytic agent.
Topics: Analgesics; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Clonidine; Electroencephalography; Extrapyramidal Tracts; Female; Hemodynamics; Kidney; Male; Motor Neurons; Muscle Relaxants, Central; Muscle Tonus; Rats; Reflex; Synapses | 1980 |
Double-blind comparison of single doses of DS103-282, baclofen and placebo for suppression of spasticity.
Topics: Adolescent; Adult; Aged; Baclofen; Clonidine; Double-Blind Method; Electromyography; Female; Hemiplegia; Humans; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Paralysis; Placebos | 1980 |
[Study of a new myorelaxant in neurological affections (author's transl)].
Topics: Activities of Daily Living; Adult; Aged; Clonidine; Drug Evaluation; Electromyography; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Muscles | 1981 |
The effects of clonidine and tizanidine on responses of nociceptive neurons in nucleus ventralis posterolateralis of the cat thalamus.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Intravenous; Animals; Cats; Chloralose; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Injections, Intravenous; Neural Pathways; Nociceptors; Physical Stimulation; Sensory Thresholds; Spinal Cord; Spinothalamic Tracts; Splanchnic Nerves; Thalamic Nuclei; Urethane | 1995 |
Analgesic action of acute and chronic intraspinally administered opiate and alpha 2-adrenergic agonists in chronic neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Evaluation Studies as Topic; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
The combination of tizanidine markedly improves the treatment with dextromethorphan of heroin addicted outpatients.
Topics: Adult; Ambulatory Care Facilities; Clonidine; Dextromethorphan; Drug Therapy, Combination; Female; Heroin Dependence; Hormones; Humans; Infant, Newborn; Male; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1995 |
A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain.
Topics: Analgesics; Animals; Chronic Disease; Clonidine; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Morphine; Nerve Compression Syndromes; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve | 1995 |
Effect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Decerebrate State; Dioxanes; Hexamethonium Compounds; Idazoxan; Male; Muscle Relaxants, Central; Norepinephrine; Phentolamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reflex; Reflex, Monosynaptic; Spinal Cord; Sympathetic Nervous System | 1993 |
The effects of central myorelaxants on synaptically-evoked primary afferent depolarization in the immature rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Agonists; Animals; Baclofen; Clonidine; Diazepam; Electric Stimulation; Evoked Potentials; Ganglia, Spinal; In Vitro Techniques; Muscle Relaxants, Central; Nerve Fibers; Neurons, Afferent; Rats; Receptors, Adrenergic, alpha-2; Spinal Cord; Synapses | 1994 |
Role of tizanidine in the treatment of spasticity.
Topics: Animals; Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity | 1994 |
Mechanisms of tizanidine action on spasticity.
Topics: Adult; Aged; Cerebrovascular Disorders; Clonidine; Electromyography; Female; H-Reflex; Hemiplegia; Humans; Interneurons; Male; Middle Aged; Motor Neurons; Muscle Relaxants, Central; Muscle Spasticity; Neural Inhibition; Neurologic Examination | 1994 |
Local cerebral glucose utilization in rats with decerebrate rigidity and effects of centrally acting muscle relaxants, diazepam and tizanidine.
Topics: Animals; Cerebellar Nuclei; Clonidine; Decerebrate State; Deoxyglucose; Diazepam; Glucose; Male; Muscle Relaxants, Central; Rats; Rats, Wistar; Vestibular Nuclei | 1993 |
Sino-atrial and atrio-ventricular node dysfunction in a case of tizanidine overdose.
Topics: Adult; Atrioventricular Node; Clonidine; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Lorazepam; Muscle Relaxants, Central; Sinoatrial Node; Suicide, Attempted | 1995 |
Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Blood Pressure; Bradycardia; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Female; Glycopyrrolate; Heart Rate; Hemodynamics; Idazoxan; Imidazoles; Injections, Spinal; Male; Parasympatholytics; Reaction Time; Sympatholytics; Vagus Nerve; Vasoconstrictor Agents; Wakefulness; Yohimbine | 1996 |
A new drug to treat spasticity?
Topics: Clonidine; Drug Approval; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Spinal Cord Injuries; United States; United States Food and Drug Administration | 1996 |
Inhibition of alpha1-adrenoceptor-mediated contractions in isolated tail arteries and aorta of the rat by alpha2-adrenoceptor agonists.
Topics: Acetylcholine; Animals; Aorta; Arteries; Clonidine; Dose-Response Relationship, Drug; Male; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Tail; Yohimbine | 1995 |
Tizanidine and spasticity.
Topics: Clonidine; Humans; Muscle Spasticity | 1995 |
A comparison of the effects of two antispastic drugs, tizanidine and baclofen, on synaptic transmission from muscle spindle afferents to spinal interneurones in cats.
Topics: Afferent Pathways; Animals; Anticonvulsants; Baclofen; Cats; Clonidine; Dose-Response Relationship, Drug; Interneurons; Muscle Spindles; Synaptic Transmission; Time Factors | 1996 |
Tizanidine for chronic cluster headache.
Topics: Analgesics; Animals; Cats; Clonidine; Cluster Headache; Female; Humans; Male; Middle Aged | 1996 |
A case of tizanidine-induced hepatic injury.
Topics: Chemical and Drug Induced Liver Injury; Clonidine; Female; Humans; Liver; Liver Diseases; Middle Aged; Muscle Relaxants, Central; Recurrence | 1996 |
Effects of intrathecal nonnarcotic analgesics on chronic tactile allodynia in rats: alpha 2-agonists versus somatostatin analog.
Topics: Animals; Clonidine; Injections, Spinal; Male; Octreotide; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Somatostatin | 1997 |
Tizanidine for spasticity.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Clonidine; Costs and Cost Analysis; Drug Administration Schedule; Drug Interactions; Humans; Muscle Relaxants, Central; Muscle Spasticity; Randomized Controlled Trials as Topic | 1997 |
Antinociceptive interaction of intrathecal alpha2-adrenergic agonists, tizanidine and clonidine, with lidocaine in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Blood Pressure; Clonidine; Drug Interactions; Heart Rate; Injections, Spinal; Lidocaine; Male; Motor Activity; Pain; Rats; Rats, Sprague-Dawley; Yohimbine | 1997 |
[Sirdalud in the practice of the pediatric neurologist].
Topics: Adolescent; Cerebral Palsy; Child; Clonidine; Drug Evaluation; Humans; Muscle Relaxants, Central; Muscle Spasticity; Time Factors | 1997 |
[The treatment of tension headache with sirdalud].
Topics: Adult; Chronic Disease; Clonidine; Drug Evaluation; Female; Humans; Male; Muscle Relaxants, Central; Remission Induction; Tension-Type Headache; Time Factors | 1997 |
Effects of tizanidine administration on precipitated opioid withdrawal signs in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Analysis of Variance; Animals; Behavioral Symptoms; Body Temperature; Clonidine; Disease Models, Animal; Drug Interactions; Male; Morphine; Muscle Relaxants, Central; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pain Threshold; Parasympatholytics; Peristalsis; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Urination | 1998 |
Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Chronic Disease; Clonidine; Dose-Response Relationship, Drug; Female; Half-Life; Heart Rate; Infusion Pumps, Implantable; Injections, Spinal; Metabolic Clearance Rate; Motor Activity; Muscle Contraction; Pain; Pharmaceutical Vehicles; Sheep; Sleep Stages; Spinal Cord; Tissue Distribution | 1998 |
Tizanidine is an effective agent in the prevention of focal cerebral ischemia in rats: an experimental study.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Blood Pressure; Body Temperature; Carbon Dioxide; Cerebrovascular Circulation; Clonidine; Hematocrit; Ischemic Attack, Transient; Male; Oxygen; Pulse; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Modulation of responses of feline gamma-motoneurones by noradrenaline, tizanidine and clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cats; Clonidine; Electric Stimulation; Electrophysiology; Hydrogen-Ion Concentration; Iontophoresis; Motor Neurons, Gamma; Muscle Spindles; Neural Conduction; Norepinephrine; Synapses | 1998 |
Spasticity: current and future management. Royal College of Physicians, November 13, 1997.
Topics: Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Gait; Humans; Muscle Spasticity; Spinal Cord Injuries | 1998 |
[Disorders of muscle tonus and their treatment with sirdalud in patients in the early recovery period of ischemic stroke].
Topics: Adult; Aged; Brain Ischemia; Clonidine; Female; H-Reflex; Humans; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Neurophysiology; Paralysis; Parasympatholytics; Time Factors | 1998 |
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phentolamine; Prazosin; Receptors, Adrenergic, alpha-2; Seizures; Time Factors; Yohimbine | 1999 |
The effect of tizanidine on maximal electroshock seizures (MES) in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Clonidine; Electroshock; Female; Injections, Intraperitoneal; Male; Mice; Receptors, Adrenergic, alpha-2; Seizures; Yohimbine | 1999 |
[Current data on bipolar disorders, epilepsy and spasticity. 4. Neuro-Forum, Dresden].
Topics: Baclofen; Bipolar Disorder; Clonidine; Epilepsy; Female; Humans; Male; Muscle Relaxants, Central; Muscle Spasticity; Spasm | 1999 |
Scopolamine-induced convulsions in food given fasted mice: effects of clonidine and tizanidine.
Topics: Animals; Anticonvulsants; Clonidine; Fasting; Male; Mice; Scopolamine; Seizures | 1999 |
[Current data on bipolar disorders, epilepsy and spasm. 4th Neuro-Forum, Dresden].
Topics: Baclofen; Benzodiazepines; Bipolar Disorder; Clonidine; Epilepsy; Humans; Muscle Relaxants, Central; Paraplegia | 1999 |
Antinociception by epidural and systemic alpha(2)-adrenoceptor agonists and their binding affinity in rat spinal cord and brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Algorithms; Analgesia, Epidural; Analgesics, Opioid; Animals; Brain; Clonidine; Dexmedetomidine; Dose-Response Relationship, Drug; Heart Rate; In Vitro Techniques; Injections, Intramuscular; Male; Morphine; Neurons; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 2000 |
[Tizanidine in the treatment of acute withdrawal symptoms in heroin dependent patients].
Topics: Acute Disease; Adult; Analgesics; Anticonvulsants; Case-Control Studies; Clonidine; Female; Heroin; Heroin Dependence; Humans; Male; Muscle Relaxants, Central; Narcotics; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
The effect of tizanidine on chronic vasospasm in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Chronic Disease; Clonidine; Disease Models, Animal; Femoral Artery; Male; Muscle Relaxants, Central; Photomicrography; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2000 |
[Pharmacology of spasticity. Does therapy remain in deep sleep?].
Topics: Animals; Baclofen; Botulinum Toxins, Type A; Clonidine; Drug Industry; Humans; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Receptors, Adrenergic, alpha-2; Receptors, GABA-B; Research | 2000 |
Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.
Topics: Adrenergic alpha-Agonists; Angiotensin-Converting Enzyme Inhibitors; Child; Clonidine; Drug Interactions; Humans; Hypertension; Hypotension; Lisinopril; Male; Muscle Spasticity | 2000 |
Effects of adrenergic alpha2-receptor agonists on urinary bladder contraction in conscious rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Male; Muscle Contraction; Oxymetazoline; Rats; Rats, Wistar; Urinary Bladder | 2000 |
Antagonistic effects of selective alpha1-adrenoceptor antagonists MDL73005EF and tamsulosin and partial agonists clonidine and tizanidine in rat thoracic aorta and rabbit iliac artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Clonidine; Dioxins; Iliac Artery; Male; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Spiro Compounds; Sulfonamides; Tamsulosin | 2001 |
Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans.
Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Ankle; Clonidine; Cold Temperature; Electromyography; Female; Foot; Humans; Ischemia; Lidocaine; Male; Muscle, Skeletal; Neurons, Afferent; Reaction Time; Reflex, Stretch; Time Factors; Walking | 2001 |
Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Disease Models, Animal; Male; Pain, Postoperative; Rats | 2001 |
Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Disease Models, Animal; Hot Temperature; Hyperalgesia; Ligation; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatic Neuropathy | 2001 |
Low-dose tizanidine with nonsteroidal anti-inflammatory drugs for detoxification from analgesic rebound headache.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Headache Disorders; Humans; Inactivation, Metabolic; Male; Medical Records; Middle Aged | 2002 |
Treatment of spasticity.
Topics: Acetates; Amines; Aminopyridines; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Clonidine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Memantine; Muscle Spasticity; Paralysis; Rhizotomy | 2002 |
Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine.
Topics: Animals; Cervical Vertebrae; Clonidine; Imidazoline Receptors; Male; Muscle Relaxants, Central; Rats; Rats, Wistar; Receptors, Drug; Reflex; Spinal Cord Injuries | 2002 |
Determination of tizanidine in human plasma by gas chromatography-mass spectrometry.
Topics: Clonidine; Gas Chromatography-Mass Spectrometry; Humans; Muscle Relaxants, Central | 2002 |
Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Synergism; Drug Therapy, Combination; Meloxicam; Mice; Naproxen; Pain; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Stomach Ulcer; Sulfonamides; Thiazines; Thiazoles; Yohimbine | 2002 |
Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias.
Topics: Adrenergic alpha-Agonists; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Clonidine; Dextromethorphan; Excitatory Amino Acid Antagonists; Male; Ouabain; Rats; Rats, Wistar | 2002 |
Modulatory effects of alpha1-,alpha2-, and beta -receptor agonists on feline spinal interneurons with monosynaptic input from group I muscle afferents.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Afferent Pathways; Animals; Cats; Clonidine; Evoked Potentials, Motor; Female; Interneurons; Isoproterenol; Male; Mechanoreceptors; Muscle Spindles; Muscle, Skeletal; Neural Inhibition; Phenylephrine; Spinal Cord; Synaptic Transmission | 2003 |
Continuous intrathecal clonidine and tizanidine in conscious dogs: analgesic and hemodynamic effects.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Body Temperature; Body Weight; Clonidine; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Injections, Spinal; Male; Psychomotor Performance; Respiratory Mechanics | 2003 |
Tizanidine is not a cure for chronic daily headache.
Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Double-Blind Method; Headache Disorders; Humans; Treatment Failure | 2003 |
Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Dexmedetomidine; Dose-Response Relationship, Drug; Electromyography; Hypnotics and Sedatives; Imidazoles; Indans; Injections, Spinal; Motor Activity; Muscle, Skeletal; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley | 2003 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hot Temperature; Hyperalgesia; Hypotension; Injections, Spinal; Male; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2003 |
Eosinophilic exudative pleural effusion after initiation of tizanidine treatment: a case report.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Eosinophilia; Humans; Low Back Pain; Male; Pleural Effusion | 2003 |
Stability-indicating HPTLC determination of tizanidine hydrochloride in bulk drug and pharmaceutical formulations.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clonidine; Drug Contamination; Drug Stability; Pharmaceutical Preparations | 2003 |
Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.
Topics: Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Half-Life; Humans; Microsomes, Liver | 2004 |
Tizanidine for the treatment of intention myoclonus: a case series.
Topics: Adolescent; Adrenergic alpha-Agonists; Aged; Clonidine; Female; Humans; Male; Myoclonus | 2004 |
High-dose tizanidine abuse.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Humans; Muscle Relaxants, Central; Spasm; Substance Withdrawal Syndrome; Substance-Related Disorders | 2003 |
Efficacy of tizanidine hydrochloride in the treatment of myofascial face pain.
Topics: Adult; Analgesics; Clonidine; Facial Pain; Female; Humans; Male; Masticatory Muscles; Temporomandibular Joint Dysfunction Syndrome | 2004 |
Hypotension due to interaction between lisinopril and tizanidine.
Topics: Angiotensin-Converting Enzyme Inhibitors; Clonidine; Drug Interactions; Female; Humans; Hypotension; Lisinopril; Middle Aged | 2004 |
Retrospective review of Tizanidine (Zanaflex) overdose.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Charcoal; Child; Child, Preschool; Clonidine; Drug Overdose; Female; Humans; Infant; Kentucky; Male; Middle Aged; Muscle Relaxants, Central; Poison Control Centers; Respiration, Artificial; Retrospective Studies | 2004 |
[Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].
Topics: Amines; Antiparkinson Agents; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Encephalomyelitis; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Immunoglobulins, Intravenous; Muscle Rigidity; Nipecotic Acids; Tiagabine | 2004 |
Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; Injections, Spinal; Male; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2004 |
Drug interaction of tizanidine and fluvoxamine.
Topics: Adrenergic alpha-Agonists; Aged; Antidepressive Agents, Second-Generation; Body Temperature; Cerebral Infarction; Clonidine; Drug Interactions; Female; Fluvoxamine; Heart Rate; Humans; Male; Middle Aged; Retrospective Studies | 2004 |
Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clonidine; Dosage Forms; Lactones; Sulfones | 2005 |
Simultaneous LC determination of tizanidine and rofecoxib in tablets.
Topics: Chemistry, Pharmaceutical; Chromatography, Liquid; Clonidine; Drug Combinations; Lactones; Sulfones | 2005 |
Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient.
Topics: Aged; Bradycardia; Clonidine; Female; Humans; Kidney Failure, Chronic; Muscle Cramp; Muscle Relaxants, Central; Renal Dialysis | 2005 |
[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Clonidine; Cyclooxygenase Inhibitors; Drug Interactions; Electrocardiography; Emergencies; Female; Heart Failure; Hospitalization; Humans; Lactones; Length of Stay; Low Back Pain; Middle Aged; Sulfones | 2005 |
Involuntary jerking of lower half of the body (spinal myoclonus).
Topics: Baclofen; Clonazepam; Clonidine; Diagnosis, Differential; Humans; Lower Extremity; Middle Aged; Myoclonus; Spinal Cord; Spinal Cord Diseases | 2005 |
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Muscle Relaxants, Central; Norepinephrine; Oxidopamine; Rats; Rats, Wistar; Receptors, Drug; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Spinal Cord; Sympathetic Nervous System; Time Factors | 2005 |
Mediation of late excitation from human hand muscles via parallel group II spinal and group I transcortical pathways.
Topics: Adult; Aged; Arm; Cerebral Cortex; Clonidine; Cold Temperature; Electric Stimulation; Electromyography; Hand; Humans; Hypothermia, Induced; Middle Aged; Motor Neurons; Muscle Contraction; Muscle Relaxants, Central; Muscle Spindles; Muscle, Skeletal; Reflex; Spinal Nerves; Synapses; Ulnar Nerve | 2006 |
Quantification of tizanidine in human plasma by liquid chromatography coupled to tandem mass spectrometry.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Clonidine; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2006 |
Tizanidine distribution in a postmortem case.
Topics: Adrenergic alpha-Agonists; Bile; Clonidine; Drug Interactions; Drug Overdose; Ethanol; Female; Gastrointestinal Contents; Humans; Liver; Middle Aged; Muscle Relaxants, Central; Suicide | 2006 |
In-vitro studies of tizanidine controlled-release microcapsular matrices.
Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Clonidine; Delayed-Action Preparations; Kinetics; Muscle Relaxants, Central; Solubility; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tablets | 2006 |
Drug interaction of tizanidine and ciprofloxacin: case report.
Topics: Blood Pressure; Ciprofloxacin; Clonidine; Drug Interactions; Female; Heart Rate; Humans; Middle Aged | 2006 |
Alpha-2 agonists decrease expression of morphine-induced conditioned place preference.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Clonidine; Conditioning, Operant; Male; Mice; Morphine; Receptors, Adrenergic, alpha-2; Reward; Xylazine; Yohimbine | 2008 |
The effects of medical treatment and rehabilitation in a patient with adult tethered cord syndrome in the late postoperative period.
Topics: Adult; Amines; Analgesics; Clonidine; Cyclohexanecarboxylic Acids; Exercise Therapy; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Neural Tube Defects; Postoperative Period | 2007 |
Tizanidine-induced hypotension in patients with liver cirrhosis.
Topics: Aged; Clonidine; Female; Humans; Hypotension; Liver Cirrhosis; Male; Middle Aged; Parasympatholytics; Retrospective Studies | 2008 |
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Benztropine; Clonidine; Depression, Postpartum; Female; Haiti; Haloperidol; Humans; Lorazepam; Paraparesis, Tropical Spastic; Parasympatholytics; Sertraline | 2008 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |
[Effects of intrathecal ouabain and tizanidine injection for treatment of neuropathic pain in rats].
Topics: Analgesics; Animals; Clonidine; Injections, Spinal; Ouabain; Pain; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2008 |
Medium-latency reflex response of soleus elicited by peroneal nerve stimulation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Cold Temperature; Electric Stimulation; Electromyography; Female; Hemiplegia; Humans; Ischemia; Lower Extremity; Male; Middle Aged; Motor Activity; Muscle, Skeletal; Parasympatholytics; Peroneal Nerve; Reflex; Restraint, Physical | 2009 |
Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Brimonidine Tartrate; Calcium; Clonidine; Dinoprostone; Drug Interactions; Excitatory Amino Acid Agonists; Exploratory Behavior; Hyperalgesia; Injections, Spinal; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain Measurement; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2 | 2009 |
A combined approach of chemical enhancers and sonophoresis for the transdermal delivery of tizanidine hydrochloride.
Topics: 1-Octanol; Acyclic Monoterpenes; Adjuvants, Pharmaceutic; Administration, Cutaneous; Animals; Buffers; Clonidine; Cyclohexanols; Cyclohexenes; Ethanol; Eucalyptol; In Vitro Techniques; Limonene; Mice; Mineral Oil; Monoterpenes; Myristates; Oleic Acid; Skin; Skin Absorption; Solubility; Terpenes; Ultrasonics | 2009 |
Botulinum toxin should be first-line treatment for poststroke spasticity.
Topics: Anti-Dyskinesia Agents; Botulinum Toxins; Clonidine; Humans; Muscle Relaxants, Central; Muscle Spasticity; Stroke; Survivors; Upper Extremity | 2009 |
Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets.
Topics: Adhesiveness; Administration, Oral; Adrenergic alpha-Agonists; Adult; Cheek; Chemistry, Pharmaceutical; Clonidine; Delayed-Action Preparations; Drug Stability; Humans; Models, Theoretical; Mouth Mucosa; Solubility; Tablets | 2009 |
Pediatric safety of tizanidine: clinical adverse event database and retrospective chart assessment.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Child; Child, Preschool; Clonidine; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Retrospective Studies; Young Adult | 2009 |
Drug treatments for spasticity.
Topics: Administration, Oral; Adult; Alcohols; Algorithms; Anti-Dyskinesia Agents; Baclofen; Botulinum Toxins; Child; Clonidine; Decision Trees; Humans; Injections, Intramuscular; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Patient Selection; Phenol; Safety; Sclerosing Solutions; Treatment Outcome | 2009 |
Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis.
Topics: Administration, Oral; Adult; Attention; Clonidine; Electromyography; Evoked Potentials, Somatosensory; Female; Forearm; Humans; Linear Models; Male; Middle Aged; Muscle, Skeletal; Parasympatholytics; Probability; Reflex, Stretch; Time Factors | 2010 |
Load rather than length sensitive feedback contributes to soleus muscle activity during human treadmill walking.
Topics: Adult; Afferent Pathways; Ankle Joint; Biomechanical Phenomena; Body Weight; Clonidine; Electromyography; Feedback, Physiological; Female; Humans; Leg; Male; Motor Neurons; Muscle Relaxants, Central; Muscle, Skeletal; Reflex, Stretch; Time Factors; Walking; Young Adult | 2010 |
[Therapeutic blockades and reflexotherapy in the complex treatment of tension headache].
Topics: Adult; Anesthetics, Local; Bupivacaine; Clonidine; Combined Modality Therapy; Female; Fluoxetine; Humans; Male; Middle Aged; Nerve Block; Reflexotherapy; Tension-Type Headache; Young Adult | 2010 |
Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.
Topics: Amines; Analgesics; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Double-Blind Method; Fructose; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Randomized Controlled Trials as Topic; Topiramate; Valproic Acid | 2010 |
Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Ankle Joint; Clonidine; Elasticity; Humans; Muscle Spasticity; Muscle, Skeletal; Physical Stimulation; Range of Motion, Articular; Receptors, Adrenergic, alpha-2; Reflex; Spinal Cord Injuries; Torque | 2010 |
Cervical myelopathy from spinal sarcoidosis as the unexpected initial presentation for systemic sarcoidosis.
Topics: Adult; Cervical Vertebrae; Clonidine; Contrast Media; Gadolinium DTPA; Glucocorticoids; Humans; Hypesthesia; Magnetic Resonance Imaging; Male; Muscle Relaxants, Central; Muscle Spasticity; Muscle Weakness; Prednisone; Sarcoidosis; Spinal Cord Diseases | 2010 |
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Bradycardia; Clonidine; Drug Interactions; Humans; Hypotension; Lisinopril; Male; Severity of Illness Index | 2010 |
[Clinical features of headache of tension type and principles of treatment].
Topics: Adult; Aged; Analgesics; Clonidine; Cyclohexanols; Female; Humans; Male; Masticatory Muscles; Middle Aged; Pain Threshold; Surveys and Questionnaires; Tension-Type Headache; Venlafaxine Hydrochloride; Young Adult | 2010 |
Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.
Topics: Animals; CHO Cells; Clonidine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guinea Pigs; Heart; HEK293 Cells; Humans; Long QT Syndrome; Male; Muscle Relaxants, Central; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2012 |
Tizanidine for alcohol withdrawal treatment.
Topics: Clonidine; Humans; Parasympatholytics; Substance Withdrawal Syndrome | 2011 |
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural Inhibition; Paraplegia; Rats; Rats, Sprague-Dawley; Reflex, Stretch; Spinal Cord Ischemia | 2011 |
Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain.
Topics: Administration, Intranasal; Analgesics; Animals; Cell Line; Chitosan; Clonidine; Mice; Nanoparticles; Pain; Radionuclide Imaging; Sheep; Sulfhydryl Compounds; Tissue Distribution | 2012 |
Medium-latency reflex response elicited from the flexor carpi radialis by radial nerve stimulation.
Topics: Adult; Clonidine; Electric Stimulation; Female; H-Reflex; Humans; Male; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Muscle, Skeletal; Neural Conduction; Radial Nerve; Reflex, Stretch; Wrist | 2012 |
Tizanidine and tizanidine hydrochloride: on the correct tautomeric form of tizanidine.
Topics: Clonidine; Crystallography, X-Ray; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Structure; Muscle Relaxants, Central | 2012 |
The effect of robot-assisted lokomotor training on gait recovery: a multivariate analysis.
Topics: Clonidine; Gait; Humans; Locomotion; Multivariate Analysis | 2011 |
[Clinical survey of tizanidine-induced adverse effects--impact of concomitant drugs providing cytochrome P450 1A2 modification--].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Carbamazepine; Clonidine; Cytochrome P-450 CYP1A2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Retrospective Studies; Time Factors | 2013 |
Adherence associated with oral medications in the treatment of spasticity.
Topics: Administration, Oral; Adult; Baclofen; Clonidine; Dantrolene; Female; Humans; Male; Medication Adherence; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Retrospective Studies; Young Adult | 2013 |
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanfacine; Humans; Hypotension; Incidence; Male; Poison Control Centers; Poisoning; Population Surveillance; Retrospective Studies; Survival Rate; United States | 2014 |
Therapeutic effects of anti-spastic medication on neuromuscular abnormalities in SCI: a system identification approach.
Topics: Algorithms; Ankle; Ankle Joint; Anticonvulsants; Clonidine; Electromyography; Exercise Therapy; Humans; Muscle Spasticity; Random Allocation; Range of Motion, Articular; Reflex; Robotics; Spinal Cord Injuries | 2013 |
Lower metabolic clearance of tizanidine in Japanese subjects.
Topics: Adult; Asian People; Clonidine; Cytochrome P-450 CYP1A2; Humans; Male; Metabolic Clearance Rate; White People | 2013 |
Occlusal treatment with bite splint improves dyskinesia in Parkinson's disease patient: a case report.
Topics: Activities of Daily Living; Antiparkinson Agents; Bromocriptine; Cabergoline; Clonidine; Dyskinesias; Ergolines; Female; Hand Strength; Humans; Levodopa; Middle Aged; Motor Skills; Occlusal Splints; Parkinson Disease; Posture | 2013 |
[Comparative effectiveness of different muscle relaxants in the rehabilitation of post-stroke patients with spasticity].
Topics: Aged; Baclofen; Clonidine; Comparative Effectiveness Research; Dantrolene; Female; Humans; Male; Muscle Relaxants, Central; Muscle Spasticity; Muscle Tonus; Recovery of Function; Self Report; Stroke; Stroke Rehabilitation; Tolperisone; Treatment Outcome; Walking | 2013 |
Effects of various excipients on tizanidine hydrochloride tablets prepared by direct compression.
Topics: Chemistry, Pharmaceutical; Clonidine; Excipients; Solubility; Tablets; Technology, Pharmaceutical | 2014 |
Coadministration of tramadol and tizanidine in an experimental acute pain model in rat.
Topics: Acute Pain; Analgesics; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Therapy, Combination; Female; Humans; Rats; Rats, Wistar; Tramadol | 2014 |
Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Bradycardia; Cardiac Pacing, Artificial; Clonidine; Female; Humans; Treatment Outcome | 2015 |
Normal co-ordinate analysis, molecular structural, non-linear optical, second order perturbation studies of Tizanidine by density functional theory.
Topics: Clonidine; Electrons; Models, Molecular; Molecular Conformation; Nonlinear Dynamics; Optical Phenomena; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics; Vibration | 2015 |
[Tizanidine withdrawal symptoms in stress cardiomyopathy].
Topics: Adrenergic alpha-2 Receptor Agonists; Clonidine; Electrocardiography; Humans; Male; Middle Aged; Muscle Relaxants, Central; Substance Withdrawal Syndrome; Takotsubo Cardiomyopathy | 2015 |
[Effectiveness of continuous infusion of tizanidine (Ternelin) via a feeding tube for patients with the mixed type of tetraplegia].
Topics: Child, Preschool; Clonidine; Enteral Nutrition; Female; Humans; Infant; Male; Muscle Hypertonia; Muscle Relaxants, Central; Quadriplegia; Quality of Life; Retrospective Studies; Treatment Outcome; Young Adult | 2015 |
Facilitatory effects of anti-spastic medication on robotic locomotor training in people with chronic incomplete spinal cord injury.
Topics: Adult; Aged; Biomechanical Phenomena; Clonidine; Female; Gait; Humans; Isometric Contraction; Learning; Locomotion; Male; Middle Aged; Muscle Relaxants, Central; Muscle Spasticity; Muscle Strength; Muscle, Skeletal; Range of Motion, Articular; Robotics; Spinal Cord Injuries; Treatment Outcome; Walking | 2015 |
Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity.
Topics: Administration, Oral; Adolescent; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, Preschool; Clonidine; Drug Therapy, Combination; Equinus Deformity; Female; Follow-Up Studies; Humans; Male; Muscle Spasticity; Neuromuscular Agents; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2016 |
A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Benzodiazepines; Clonidine; Diazepam; Drug Therapy, Combination; Female; Glutamate Decarboxylase; Humans; Immunologic Factors; Muscle Relaxants, Central; Remission Induction; Rituximab; Stiff-Person Syndrome | 2015 |
A severe interaction between Tizanidine and Ciprofloxacin.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Clonidine; Drug Interactions; Female; Humans; Middle Aged; Muscle Relaxants, Central; Severity of Illness Index | 2015 |
Evaluation of tizanidine as a marker of canine CYP1A2 activity.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzoflavones; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dogs; Enrofloxacin; Female; Fluoroquinolones; Microsomes, Liver; Molecular Probes; Phenacetin; Substrate Specificity; Theophylline | 2016 |
[The principles of pharmacotherapy of poststroke shoulder pain].
Topics: Amines; Amitriptyline; Anti-Inflammatory Agents; Clonidine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lidocaine; Male; Pregabalin; Shoulder Pain; Stroke | 2015 |
Quantitative target and systematic non-target analysis of polar organic micro-pollutants along the river Rhine using high-resolution mass-spectrometry--Identification of unknown sources and compounds.
Topics: Amines; Clonidine; Cyclohexanecarboxylic Acids; Europe; Gabapentin; gamma-Aminobutyric Acid; Imidazoles; Mass Spectrometry; Metformin; Pesticides; Pharmaceutical Preparations; Rivers; Seasons; Solid Phase Extraction; Thiazines; Wastewater; Water Pollutants, Chemical; Water Pollution, Chemical | 2015 |
Comparison between the therapeutic effects of robotic-assisted locomotor training and an anti-spastic medication on spasticity.
Topics: Ankle Joint; Clonidine; Electromyography; Humans; Motor Activity; Muscle Relaxants, Central; Muscle Spasticity; Physical Therapy Modalities; Range of Motion, Articular; Robotics; Spinal Cord Injuries | 2015 |
Magnetic molecularly imprinted polymer nanoparticles for selective solid phase extraction and pre-concentration of Tizanidine in human urine.
Topics: Clonidine; Humans; Hydrogen-Ion Concentration; Limit of Detection; Molecular Imprinting; Nanoparticles; Polymers; Reproducibility of Results; Solid Phase Extraction; Temperature | 2016 |
Misanalysis of Urinalysis: A Teachable Moment.
Topics: Analgesics, Opioid; Anti-Bacterial Agents; Cefpodoxime; Ceftizoxime; Clonidine; Diagnostic Errors; Enterocolitis, Pseudomembranous; Female; Hospitalization; Humans; Low Back Pain; Middle Aged; Muscle Relaxants, Central; Pyuria; Substance Withdrawal Syndrome; Tramadol; Urinalysis; Urinary Tract Infections; Vancomycin | 2016 |
Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Atorvastatin; Clonidine; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Female; Humans; Long QT Syndrome; Macrolides; Male; Medication Errors; Middle Aged; Quinolones; Risk Factors; Simvastatin; Tertiary Care Centers; Torsades de Pointes; Young Adult | 2016 |
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers.
Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline | 2016 |
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome.
Topics: Adult; Analgesics; Cervical Vertebrae; Clonidine; Complex Regional Pain Syndromes; Diclofenac; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; Humans; Lamotrigine; Male; Oxycodone; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Spinal Cord Stimulation | 2017 |
Nanotransfersomes-loaded thermosensitive in situ gel as a rectal delivery system of tizanidine HCl: preparation, in vitro and in vivo performance.
Topics: Administration, Rectal; Animals; Biological Availability; Chemistry, Pharmaceutical; Clonidine; Drug Carriers; Drug Delivery Systems; Gels; Hypromellose Derivatives; Male; Nanoparticles; Particle Size; Permeability; Phosphatidylcholines; Poloxamer; Polysorbates; Rabbits; Solubility | 2017 |
Thiolation of arabinoxylan and its application in the fabrication of controlled release mucoadhesive oral films.
Topics: Adhesives; Clonidine; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Mouth Mucosa; Sulfhydryl Compounds; Xylans | 2017 |
A novel non-opioid protocol for medically supervised opioid withdrawal and transition to antagonist treatment.
Topics: Adult; Amines; Analgesics, Opioid; Buprenorphine; Clonidine; Counseling; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydroxyzine; Male; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Retrospective Studies; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult | 2018 |
Early outcomes after intrathecal baclofen therapy in ambulatory patients with multiple sclerosis.
Topics: Administration, Oral; Aged; Ambulatory Care; Baclofen; Clonidine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Outcome Assessment, Health Care; Pain Measurement; Retrospective Studies; Walking | 2018 |
Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography.
Topics: Acetaminophen; Chromatography, Liquid; Clonidine; Diclofenac; Humans; Limit of Detection; Linear Models; Micelles; Reproducibility of Results; Sulfonamides; Tablets | 2018 |
Variable impact of tizanidine on the medium latency reflex of upper and lower limbs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Afferent Pathways; Clonidine; Electromyography; Female; Humans; Interneurons; Lower Extremity; Male; Motor Activity; Motor Neurons; Muscle, Skeletal; Neurons, Afferent; Reflex; Robotics; Upper Extremity; Young Adult | 2018 |
Surface modification and evaluation of bacterial cellulose for drug delivery.
Topics: Cellulose; Clonidine; Drug Carriers; Drug Liberation; Famotidine; Gluconacetobacter xylinus; Kinetics; Solubility; Surface Properties; Water | 2018 |
Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation.
Topics: Adhesiveness; Administration, Buccal; Animals; Biological Availability; Chemistry, Pharmaceutical; Clonidine; Cross-Over Studies; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Liberation; Half-Life; Hypromellose Derivatives; Male; Meloxicam; Mouth Mucosa; Rabbits; Solubility; Thiazines; Thiazoles; Xylans | 2018 |
Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report.
Topics: Adult; Analgesics; Atrioventricular Block; Bradycardia; Cardiac Pacing, Artificial; Clonidine; Drug Therapy, Combination; Humans; Male; Neck Pain; Phenylpropionates | 2018 |
Trauma-induced adiposis dolorosa (Dercum's disease).
Topics: Accidents, Traffic; Adipose Tissue; Adiposis Dolorosa; Adult; Amitriptyline; Analgesics, Non-Narcotic; Angiomyolipoma; Baclofen; Chronic Pain; Clonidine; Diagnosis, Differential; Humans; Ibuprofen; Male; Muscle Relaxants, Central; Tomography, X-Ray Computed; Upper Extremity | 2018 |
Transcutaneous Electrical Nerve Stimulation in Treatment of Occipital Neuralgia: A Case Report.
Topics: Adult; Analgesics; Clonidine; Female; Headache Disorders; Humans; Neck Pain; Neuralgia; Occipital Lobe; Pain Management; Spinal Nerves; Transcutaneous Electric Nerve Stimulation; Treatment Outcome | 2018 |
Evaluation of the effects of occlusal splint, trigger point injection and arthrocentesis in the treatment of internal derangement patients with myofascial pain disorders.
Topics: Arthrocentesis; Clonidine; Combined Modality Therapy; Humans; Injections; Masticatory Muscles; Meloxicam; Myofascial Pain Syndromes; Occlusal Splints; Pain Measurement; Temporomandibular Joint Disorders; Temporomandibular Joint Dysfunction Syndrome; Treatment Outcome; Trigger Points; Turkey; Visual Analog Scale | 2018 |
Analysis of Drug-Drug Interactions in Swiss Claims Data Using Tizanidine and Ciprofloxacin as a Prototypical Contraindicated Combination.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Ciprofloxacin; Clonidine; Cohort Studies; Contraindications, Drug; Databases, Factual; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Hospitalization; Humans; Insurance Claim Review; Male; Middle Aged; Patient Acceptance of Health Care; Patient Safety; Pharmacoepidemiology; Retrospective Studies; Switzerland; Young Adult | 2018 |
A comparative study of sterically and electro-statically stabilized silver nanoparticles for the determination of muscle relaxant tizanidine: Insights of localized surface plasmon resonance, surface enhanced Raman spectroscopy and electrocatalytic activit
Topics: Catalysis; Clonidine; Electrochemical Techniques; Metal Nanoparticles; Muscle Relaxants, Central; Silver; Spectrum Analysis, Raman; Surface Plasmon Resonance | 2018 |
Tizanidine is not effective treating EPMS.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Biperiden; Cholinergic Antagonists; Clonidine; Clopenthixol; Female; Humans; Movement Disorders; Schizophrenia; Treatment Outcome | 2018 |
Fabrication and characterization of matrix type transdermal patches loaded with tizanidine hydrochloride: potential sustained release delivery system.
Topics: Administration, Cutaneous; Animals; Biological Availability; Clonidine; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Excipients; Materials Testing; Muscle Relaxants, Central; Myalgia; Polymers; Rabbits; Skin; Skin Absorption; Transdermal Patch | 2018 |
Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization.
Topics: Administration, Cutaneous; Animals; Bile Acids and Salts; Biological Availability; Cholesterol; Clonidine; Drug Liberation; Liposomes; Male; Nanoparticles; Neuromuscular Agents; Particle Size; Permeability; Rats; Skin Absorption; Surface-Active Agents | 2019 |
Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway.
Topics: Analgesics; Animals; Clonidine; Interleukin-1beta; Interleukin-6; Male; Neuralgia; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2018 |
Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Topics: Adult; Clonidine; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Therapy, Combination; Female; Humans; Hypotension; Male; Middle Aged; Muscle Relaxants, Central; Polypharmacy; Retrospective Studies; Risk Factors | 2019 |
Optimization of Microemulgel for Tizanidine Hydrochloride.
Topics: Administration, Cutaneous; Animals; Biological Availability; Cells, Cultured; Chickens; Clonidine; Drug Delivery Systems; Humans; Ileum; Microgels; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Myristates; Spinal Cord Diseases | 2020 |
Tizanidine hydrochloride exhibits a cytotoxic effect on osteosarcoma cells through the PI3K/AKT signaling pathway.
Topics: Anticonvulsants; Bone Neoplasms; Cell Movement; Cell Proliferation; Clonidine; Gene Expression Regulation, Neoplastic; Humans; Osteosarcoma; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Cells, Cultured | 2019 |
Microneedle-Mediated Transdermal Delivery of Tizanidine Hydrochloride.
Topics: Administration, Cutaneous; Animals; Clonidine; Drug Liberation; Epidermis; Female; Membranes, Artificial; Microinjections; Microscopy, Electron, Scanning; Needles; Rats; Rats, Wistar; Skin; Workflow | 2020 |
Paroxysmal Hypertension Associated With Presyncope.
Topics: Clonidine; Female; Humans; Hypertension; Low Back Pain; Middle Aged; Muscle Relaxants, Central; Syncope | 2019 |
Neurogenic orthostatic hypotension induced by tizanidine.
Topics: Adult; Clonidine; Female; Humans; Hypotension, Orthostatic; Middle Aged; Muscle Relaxants, Central; Tilt-Table Test | 2020 |
Development of tizanidine loaded aspasomes as transdermal delivery system:
Topics: Administration, Cutaneous; Animals; Clonidine; Drug Carriers; Drug Delivery Systems; Drug Development; Liposomes; Male; Particle Size; Rats; Rats, Wistar; Skin; Skin Absorption | 2021 |
Italian consensus on treatment of spasticity in multiple sclerosis.
Topics: Baclofen; Botulinum Toxins; Clonidine; Consensus; Disease Management; Gabapentin; Humans; Injections, Intramuscular; Italy; Multiple Sclerosis; Muscle Spasticity; Quality of Life; Transcutaneous Electric Nerve Stimulation | 2020 |
Formulation development and optimization studies of mouth dissolving tablets of tizanidine HCl.
Topics: Administration, Oral; Analgesics; Clonidine; Compressive Strength; Drug Compounding; Humans; Solubility; Tablets | 2020 |
Formulation design, characterization and in vitro drug release study of orodispersible film comprising BCS class II drugs.
Topics: Administration, Oral; Biological Products; Clonidine; Drug Carriers; Drug Compounding; Drug Design; Drug Liberation; Meloxicam; Solubility; Spectroscopy, Fourier Transform Infrared | 2020 |
Thermoreversible Switchlike Electrocatalytic Reduction of Tizanidine Based on a Graphene Oxide Tethered Stimuli-Responsive Smart Surface Supported Pd Catalyst.
Topics: Caprolactam; Catalysis; Clonidine; Electrochemical Techniques; Electrodes; Graphite; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Nanocomposites; Palladium; Polymers; Reproducibility of Results; Surface Properties; Temperature | 2020 |
Development of Solid Self-Microemulsifying System of Tizanidine Hydrochloride for Oral Bioavailability Enhancement: In Vitro and In Vivo Evaluation.
Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Clonidine; Emulsions; In Vitro Techniques; Male; Rabbits; Solubility; Tablets | 2020 |
Development and Stability Control of Pediatric Oral Tizanidine Hydrochloride Formulations for Hospital Use.
Topics: Administration, Oral; Child; Clonidine; Drug Stability; Hospitals; Humans; Muscle Relaxants, Central; Pediatrics; Reproducibility of Results | 2020 |
High dose naloxone for acute tizanidine overdose in the emergency department: a case report.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Drug Overdose; Emergency Service, Hospital; Female; Humans; Hyperglycemia; Naloxone | 2021 |
Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Area Under Curve; Ciprofloxacin; Clonidine; Databases, Factual; Drug Interactions; Female; Humans; Male; Middle Aged; Pharmacovigilance; Retrospective Studies; World Health Organization; Young Adult | 2021 |
Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption.
Topics: Biotransformation; Cigarette Smoking; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Humans; Tobacco Products | 2021 |
Potassium wasting nephropathy in the setting of tizanidine overdose: a case report.
Topics: Clonidine; Humans; Hypokalemia; Kidney Diseases; Potassium | 2021 |
Derma roller mediated transdermal delivery of tizanidine invasomes for the management of skeletal muscle spasms.
Topics: Administration, Cutaneous; Animals; Clonidine; Drug Delivery Systems; Muscle, Skeletal; Rats; Spasm | 2021 |
[Focus on tizanidine in primary care medecine].
Topics: Clonidine; Drug-Related Side Effects and Adverse Reactions; Humans; Primary Health Care | 2021 |
Liquid chromatography-tandem mass spectrometry and confirmation by liquid chromatography-high-resolution mass spectrometry hair tests to evidence use of tizanidine by racing cyclists.
Topics: Adrenergic alpha-2 Receptor Agonists; Athletes; Bicycling; Chromatography, Liquid; Clonidine; Doping in Sports; Hair; Humans; Substance Abuse Detection; Tandem Mass Spectrometry | 2022 |
Sex-dependent antiallodynic effect of α
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Female; Hyperalgesia; Male; Neuralgia; Rats | 2022 |
Development of Biocompatible Nanoparticles of Tizanidine Hydrochloride in Orodispersible Films:
Topics: Animals; Biological Availability; Carcinoma; Clonidine; Drug Delivery Systems; Nanoparticles; Polymers; Swine | 2022 |
Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.
Topics: Ciprofloxacin; Clonidine; Cohort Studies; Drug Interactions; Female; Humans; Hypotension; Middle Aged | 2022 |
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Topics: Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Humans; Liver; Models, Biological; Permeability | 2022 |
A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS).
Topics: Adverse Drug Reaction Reporting Systems; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Fluvoxamine; Humans; Hypotension; Male; Middle Aged; United States; United States Food and Drug Administration | 2022 |
Formulation of tizanidine hydrochloride-loaded provesicular system for improved oral delivery and therapeutic activity employing a 2
Topics: Animals; Clonidine; gamma-Aminobutyric Acid; Liposomes; Particle Size; Rats | 2023 |
Authors' Response to Yoshihiro Noguchi's Comment on: "A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS)".
Topics: Adverse Drug Reaction Reporting Systems; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Humans | 2022 |
Tizanidine: An overlooked alternative muscle relaxant for older patients.
Topics: Clonidine; Humans; Muscle Relaxants, Central; Muscles | 2023 |
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine.
Topics: Administration, Buccal; Biological Availability; Chitosan; Clonidine; Drug Delivery Systems; Mouth Mucosa | 2023 |