clonidine has been researched along with theophylline in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (44.55) | 18.7374 |
| 1990's | 7 (6.93) | 18.2507 |
| 2000's | 13 (12.87) | 29.6817 |
| 2010's | 36 (35.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, J; Chen, X; Huang, L; Li, X; Sun, Y | 1 |
| Huang, L; Li, X; Meng, F; Miao, H; Sun, Y | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bai, P; Chen, C; Hu, K; Li, T; Liu, W; Ma, Q; Pan, W; Peng, K; Sang, Z; Yu, L; Zhang, X | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X | 1 |
| Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Hao, L; Huang, W; Jin, H; Liang, L; Niu, Y; Wang, C; Wang, W; Xu, F; Xu, P; Yan, G | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Fujiwara, M; Oishi, R; Razzak, A; Ueki, S | 1 |
| Chilliard, Y; Gagliostro, G | 1 |
| Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z | 1 |
| Gilbertsen, RB; Lesch, ME; Schrier, DJ; Wright, CD | 1 |
| Sawynok, J; Steardo, L | 1 |
| Livingston, A; Morris, B | 1 |
| Holtzman, SG | 1 |
| Kleven, MS; Sparber, SB | 1 |
| Kotecha, N; Neild, TO | 1 |
| Forse, RA; Gagner, M; Leibel, R | 1 |
| Majewski, H; Murphy, TV | 1 |
| Gotoh, K; Hori, M; Inoue, M; Iwakura, K; Kamada, T; Kitabatake, A; Kitakaze, M; Sato, H | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Glikfeld, P; Guy, RH; Hinz, RS | 1 |
| Hara, T; Kajimura, N; Kaneyuki, H; Mashimoto, S; Mizuki, Y; Ushijima, I; Yamada, M | 1 |
| Furukawa, T; Inoue, T; Katsuragi, T | 1 |
| Ng, TB | 1 |
| Hu, CY; Mersmann, HJ; Novakofski, J | 1 |
| Carpéné, C; Lavau, M; Rebourcet, MC | 1 |
| Giudicelli, Y; Leneveu, MC; Pecquery, R | 1 |
| Forse, RA; Gagner, M; Shizgal, HM | 1 |
| Kharin, NA; Komissarov, IV; Serdiuk, SE | 1 |
| Ahsan, MA; Naftalin, RJ; Smith, PM | 1 |
| Richelsen, B | 1 |
| DeLander, GE; Hopkins, CJ | 1 |
| Askanazi, J; Forse, RA; Hirsch, J; Kinney, JM; Leibel, R | 1 |
| Karppanen, HO; Westermann, E | 1 |
| Collier, HO; Tucker, JF | 1 |
| Berlan, M; Lac, DT; Lafontan, M; Tran, MA | 1 |
| Furukawa, T; Katsuragi, T; Ushijima, I | 2 |
| Clark, BG; Vestal, RE | 1 |
| Berlan, M; Lafontan, M | 3 |
| Galloway, MP; Roth, RH | 2 |
| Grant, SJ; Redmond, DE | 2 |
| Curtis-Prior, PB; Tan, S | 1 |
| Gorewit, RC | 1 |
| Fain, JN; Garcia-Sainz, JA; Li, SY | 1 |
| Berlan, M; Carpene, C; Dang-Tran, L; Lafontan, M | 1 |
| Berlan, M; Carpene, C; Lafontan, M | 1 |
| Arner, P; Engfeldt, P; Kimura, H; Ostman, J; Wahrenberg, H | 1 |
| Maggi, CA; Meli, A; Santicioli, P | 1 |
| Apfelbaum, M; Banegas, E; Davilla, M; Rozen, R | 1 |
| Berlan, M; Carpene, C; Dang Tran, L; Lafontan, M | 1 |
| Gilson, TL; Kennedy, AD; Rampersand, T | 1 |
| Hushcha, TO; Luik, AI; Mischenko, NI; Mogilevich, SE; Naboka, YN | 1 |
| Amabeoku, GJ | 1 |
| Capecchi, PL; Colafati, M; Di Perri, T; Pasini, FL; Puccetti, L; Randisi, P | 1 |
| Honda, K; Inomata, S; Misawa, S; Nagashima, A; Tanaka, E | 1 |
| Backman, JT; Granfors, MT; Laitila, J; Neuvonen, PJ | 1 |
| Backman, JT; Neuvonen, PJ; Schröder, MT | 1 |
| Isoherranen, N; Ke, AB; Nallani, SC; Rostami-Hodjegan, A; Unadkat, JD; Zhao, P | 1 |
| Mansoori, E; Moezi, L; Niknahad, H; Shafaroodi, H | 1 |
| Adcock, JM; Daniels, JS; Locuson, CW; Williams, P | 1 |
| Chiba, K; Haraya, K; Kato, M; Sugiyama, Y | 1 |
2 review(s) available for clonidine and theophylline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pertussis Vaccine; Scopolamine; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Yohimbine | 1984 |
2 trial(s) available for clonidine and theophylline
| Article | Year |
|---|---|
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Area Under Curve; Caffeine; Clonidine; Contraceptives, Oral, Combined; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Ethinyl Estradiol; Female; Half-Life; Humans; Norpregnenes; Theophylline | 2005 |
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Half-Life; Humans; Male; Sex Factors; Sleep Stages; Smoking; Theophylline | 2008 |
97 other study(ies) available for clonidine and theophylline
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine | 2013 |
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates | 2014 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alkanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Drug Evaluation, Preclinical; Ethylamines; Humans; Hydrogen Peroxide; Neuroprotective Agents; PC12 Cells; Rats | 2016 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones | 2017 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.
Topics: Acetamides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram | 2019 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline | 1977 |
Duodenal rapeseed oil infusion in early and midlactation cows. 4. In vivo and in vitro adipose tissue lipolytic responses.
Topics: Adenosine Deaminase; Adipose Tissue; Animals; Brassica; Cattle; Clonidine; Duodenum; Energy Metabolism; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Female; Glycerol; Isoproterenol; Lactation; Lipolysis; Plant Oils; Rapeseed Oil; Theophylline | 1991 |
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines | 1990 |
The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.
Topics: Adenosine; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Captopril; Carrageenan; Clonidine; Leukocyte Count; Minoxidil; Neutrophils; Pleurisy; Rats; Receptors, Purinergic; Superoxides; Theophylline | 1990 |
Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Baclofen; Clonidine; Drug Interactions; Male; Neural Pathways; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Reaction Time; Theophylline | 1985 |
Effects of drugs which influence noradrenergic activity on metenkephalin levels in specific brain areas.
Topics: 1-Methyl-3-isobutylxanthine; Amygdala; Animals; Brain Chemistry; Clonidine; Enkephalin, Methionine; Locus Coeruleus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Synaptic Transmission; Thalamic Nuclei; Theophylline | 1986 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
Attenuation of isobutylmethylxanthine-induced suppression of operant behavior by pretreatment of rats with clonidine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clonidine; Conditioning, Operant; Male; Narcotics; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance Withdrawal Syndrome; Theophylline | 1987 |
A study of the phasic response of arterioles of the guinea pig small intestine to prolonged exposure to norepinephrine.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arterioles; Clonidine; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Isoproterenol; Membrane Potentials; Norepinephrine; Oxidation-Reduction; Propranolol; Temperature; Theophylline; Vasoconstriction; Yohimbine | 1989 |
The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte.
Topics: Adipose Tissue; Cholera Toxin; Clonidine; Endotoxins; Escherichia coli; Female; GTP-Binding Proteins; Humans; Isoproterenol; Lipolysis; Male; Middle Aged; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Theophylline | 1989 |
Modulation of noradrenaline release in slices of rat kidney cortex through alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Indomethacin; Kidney Cortex; Male; Methoxamine; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation; Theophylline | 1989 |
Beneficial effects of alpha 2-adrenoceptor activity on ischemic myocardium during coronary hypoperfusion in dogs.
Topics: Acidosis; Adenosine; Animals; Blood Pressure; Clonidine; Coronary Circulation; Coronary Disease; Cyclic AMP; Dogs; Hemodynamics; Lactates; Myocardial Contraction; Myocardium; Norepinephrine; Oxygen Consumption; Propranolol; Receptors, Adrenergic, alpha; Theophylline; Vasodilation; Yohimbine | 1989 |
Inositol phospholipid hydrolysis and potentiation of cyclic AMP formation by noradrenaline in rat cerebral cortex slices are not mediated by the same alpha-adrenoceptor subtypes.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Cyclic AMP; Hydrolysis; Inositol Phosphates; Isoproterenol; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sugar Phosphates; Theophylline; Yohimbine | 1989 |
Noninvasive sampling of biological fluids by iontophoresis.
Topics: Animals; Body Fluids; Clonidine; Glucose; In Vitro Techniques; Iontophoresis; Mice; Mice, Hairless; Skin; Theophylline | 1989 |
Effects of dilazep (Comelian) on the central purinergic system: inhibitory effects on clonidine-induced aggressive behavior.
Topics: Aggression; Animals; Azepines; Caffeine; Clonidine; Dilazep; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Phenylisopropyladenosine; Purines; Theophylline | 1989 |
Antagonism by clonidine of the adenosine-induced inhibition of the twitch contraction of the guinea-pig Oddi sphincter.
Topics: Adenosine; Alprostadil; Ampulla of Vater; Animals; Clonidine; Dipyridamole; Electric Stimulation; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenylisopropyladenosine; Prostaglandins E; Reserpine; Sphincter of Oddi; Theophylline; Yohimbine | 1985 |
Adrenergic control of lipolysis in adipocytes of several mammalian species.
Topics: Adipose Tissue; Animals; Cats; Clonidine; Cricetinae; Epinephrine; Gerbillinae; Isoproterenol; Lipolysis; Male; Mesocricetus; Mice; Mice, Inbred ICR; Phentolamine; Phenylephrine; Propranolol; Species Specificity; Theophylline | 1985 |
Hormonal control of porcine adipose tissue fatty acid release and cyclic AMP concentration.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Animals; Clonidine; Cyclic AMP; Dobutamine; Epinephrine; Fatty Acids, Nonesterified; Female; Fenoterol; Isoproterenol; Lipolysis; Phentolamine; Swine; Theophylline | 1987 |
Evidence of functional alpha 2-adrenergic receptors in adult-rat adipocytes by using the agonist UK 14304.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Age Factors; Animals; Brimonidine Tartrate; Cell Membrane; Clonidine; Epinephrine; In Vitro Techniques; Lipolysis; Male; Quinoxalines; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Adrenergic, alpha; Theophylline | 1988 |
Estradiol treatment decreases the lipolytic responses of hamster white adipocytes through a reduction in the activity of the adenylate cyclase catalytic subunit.
Topics: Adenylyl Cyclase Inhibitors; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Clonidine; Cricetinae; Cyclic AMP; Epinephrine; Estradiol; Glycerol; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Lipolysis; Male; Mesocricetus; Propanolamines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Theophylline | 1986 |
The effect of interleukin-1 and interleukin-2 on the adrenergic control of hormone-sensitive lipase in the human adipocyte.
Topics: Adipose Tissue; Biopsy; Cells, Cultured; Clonidine; Female; Humans; Interleukin-1; Interleukin-2; Isoproterenol; Lipolysis; Male; Middle Aged; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sterol Esterase; Theophylline | 1986 |
[Theophylline-induced changes in the presynaptic effects of adenosine, baclofen, clofelin and morphine in the myenteric plexus of the guinea pig].
Topics: Adenosine; Animals; Baclofen; Clonidine; Drug Interactions; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Myenteric Plexus; Receptors, Cholinergic; Receptors, Neurotransmitter; Theophylline | 1987 |
A submucosal mechanism for catecholamine-induced increases in fluid absorption in rabbit ileum in vitro.
Topics: Animals; Carbachol; Clonidine; Dopamine; Electric Conductivity; Ileum; In Vitro Techniques; Intestinal Absorption; Male; Mannitol; Norepinephrine; Rabbits; Theophylline; Water; Yohimbine | 1988 |
Prostaglandin E2 action and binding in human adipocytes: effects of sex, age, and obesity.
Topics: Adenosine Deaminase; Adipose Tissue; Adolescent; Adult; Age Factors; Aged; Clonidine; Dinoprostone; Female; Humans; Lipolysis; Male; Middle Aged; Obesity; Phenylisopropyladenosine; Prostaglandins E; Sex Factors; Theophylline | 1988 |
Interdependence of spinal adenosinergic, serotonergic and noradrenergic systems mediating antinociception.
Topics: Adenosine; Animals; Clonidine; Male; Methysergide; Mice; Nociceptors; Norepinephrine; Phentolamine; Reaction Time; Serotonin; Spinal Cord; Theophylline | 1987 |
Adrenergic control of adipocyte lipolysis in trauma and sepsis.
Topics: Adipose Tissue; Adult; Aged; Clonidine; Energy Metabolism; Female; Humans; Isoproterenol; Lipolysis; Male; Middle Aged; Receptors, Adrenergic; Sepsis; Theophylline; Triglycerides; Wounds and Injuries | 1987 |
Increased production of cyclic AMP in gastric tissue by stimulation of histamine2 (H2)-receptors.
Topics: Animals; Binding, Competitive; Clonidine; Cyclic AMP; Diphenhydramine; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Rats; Receptors, Drug; Theophylline; Thiourea | 1973 |
Interplay of alpha-2 and beta adrenoceptors in the control of free fatty acid release from bone marrow adipose tissue.
Topics: Adenosine Deaminase; Adipose Tissue; Animals; Bone Marrow; Clonidine; Dogs; Epinephrine; Fatty Acids, Nonesterified; Isoproterenol; Perfusion; Phentolamine; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Theophylline; Yohimbine | 1984 |
The clonidine-induced self-injurious behavior of mice involves purinergic mechanisms.
Topics: Aggression; Animals; Clonidine; Drug Interactions; Food Deprivation; Humans; Male; Mice; Mice, Inbred Strains; Purines; Receptors, Cell Surface; Receptors, Purinergic; Self Mutilation; Theophylline | 1984 |
Involvement of adenosine receptor activities in aggressive responses produced by clonidine in mice.
Topics: Adenosine; Aggression; Animals; Apomorphine; Bicuculline; Clonidine; Diazepam; Dipyridamole; Humans; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1984 |
Adverse drug reactions in the elderly: case studies.
Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonidine; Dienestrol; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydralazine; Lung Diseases; Male; Middle Aged; Nitrofurantoin; Pancreatitis; Papaverine; Peripheral Nervous System Diseases; Procainamide; Propranolol; Sulindac; Theophylline; Timolol | 1984 |
Evidence for the alpha 2 nature of the alpha-adrenergic receptor inhibiting lipolysis in human fat cells.
Topics: Adipose Tissue; Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Clonidine; Drug Interactions; Epinephrine; Fatty Acids, Nonesterified; Humans; In Vitro Techniques; Lipolysis; Middle Aged; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Theophylline | 1980 |
Inhibitory alpha-2 adrenoceptors in human adipose tissue.
Topics: 1-Naphthylamine; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding Sites; Clonidine; Humans; Imidazoles; In Vitro Techniques; Lipolysis; Phentolamine; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Theophylline; Yohimbine | 1981 |
Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cerebellum; Clonidine; Diazepam; Hippocampus; Kinetics; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Clonidine; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Theophylline | 1982 |
Methylxanthine activation of noradrenergic unit activity and reversal by clonidine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clonidine; Electrophysiology; Locus Coeruleus; Male; Nalorphine; Neurons; Norepinephrine; Rats; Sympathetic Nervous System; Theophylline | 1982 |
Neuropharmacology of 3-isobutylmethylxanthine: effects on central noradrenergic systems in vivo.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Axons; Brain; Clonidine; Diazepam; Dihydroxyphenylalanine; Hydroxylation; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Tyrosine 3-Monooxygenase; Yohimbine | 1983 |
Comparative effects of RX 781094, mianserin, yohimbine, rauwolscine and prazosin in reversing clonidine inhibition of MIX-stimulated lipolysis in hamster isolated white fat cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Clonidine; Cricetinae; Dioxanes; Epididymis; Idazoxan; In Vitro Techniques; Lipolysis; Male; Mianserin; Prazosin; Theophylline; Yohimbine | 1984 |
Effects of clonidine on glucose production and insulin secretion of cattle.
Topics: Animals; Blood Glucose; Cattle; Clonidine; Cyclic AMP; Female; In Vitro Techniques; Insulin; Insulin Secretion; Liver; Theophylline | 1980 |
Alpha 2 adrenergic amines, adenosine and prostaglandins inhibit lipolysis and cyclic AMP accumulation in hamster adipocytes in the absence of extracellular sodium.
Topics: Adenosine; Adenosine Deaminase; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Clonidine; Cricetinae; Cyclic AMP; Lipolysis; Mesocricetus; Phenylisopropyladenosine; Prostaglandins E; Sodium; Theophylline | 1981 |
Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization.
Topics: Adipose Tissue; Animals; Clonidine; Dogs; Epinephrine; Isoproterenol; Lipolysis; Obesity; Prazosin; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Theophylline; Yohimbine | 1982 |
The alpha 2-adrenergic receptor of human fat cells: comparative study of alpha 2-adrenergic radioligand binding and biological response.
Topics: Adipose Tissue; Binding, Competitive; Cell Membrane; Clonidine; Epinephrine; Female; Humans; Isoproterenol; Lipolysis; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Theophylline; Tritium; Yohimbine | 1982 |
Influence of development and reduction of fat stores on the antilipolytic alpha 2-adrenoceptor in hamster adipocytes: comparison with adenosine and beta-adrenergic lipolytic responses.
Topics: Adenosine; Adipose Tissue; Animals; Clonidine; Cricetinae; Imidazoline Receptors; Isoproterenol; Kinetics; Lipolysis; Male; Mesocricetus; Phenylisopropyladenosine; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Theophylline | 1983 |
Influence of fasting on lipolytic response to adrenergic agonists and on adrenergic receptors in subcutaneous adipocytes.
Topics: Adipose Tissue; Adult; Clonidine; Dihydroalprenolol; Fasting; Female; Glycerol; Humans; In Vitro Techniques; Isoproterenol; Lipolysis; Middle Aged; Receptors, Adrenergic; Sympathomimetics; Theophylline | 1984 |
The effects of clonidine on electrically-induced contractions of rat detrusor strips in vitro.
Topics: Acetylcholine; Animals; Atropine; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Sympatholytics; Theophylline; Urinary Bladder | 1983 |
Effects of a very-low-calorie diet on adrenergic responsiveness in human adipose tissue.
Topics: Adipose Tissue; Adult; Clonidine; Diet, Reducing; Female; Humans; Isoproterenol; Lipolysis; Middle Aged; Obesity; Receptors, Adrenergic; Theophylline | 1984 |
Clonidine-induced lipolysis in dog adipocytes by stimulation of histamine (H2)-receptors.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Clonidine; Dogs; Histamine; Lipolysis; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2; Stimulation, Chemical; Theophylline | 1981 |
Effects of breed and adipose depot location on responsiveness and sensitivity to adrenergic stimulation in ovine adipose tissue.
Topics: Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Body Weight; Cell Size; Clonidine; Epinephrine; Female; Injections, Intravenous; Injections, Subcutaneous; Isoproterenol; Lipolysis; Propranolol; Sheep; Species Specificity; Theophylline; Tissue Preservation; Vasodilator Agents | 1996 |
The influence of pH alteration and pharmacological modulators of adenylate cyclase system on human serum albumin conformation.
Topics: Adenylyl Cyclases; Carbachol; Clonidine; Humans; Hydrogen-Ion Concentration; Isoproterenol; Propranolol; Protein Conformation; Serum Albumin; Theophylline; Yohimbine | 1998 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Clonidine; Dextromethorphan; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ketamine; Mice; Muscimol; N-Methylaspartate; Picrotoxin; Receptors, GABA; Receptors, Glutamate; Seizures; Theophylline | 1999 |
Systemic adenosine increase during cold pressor test is dependent on sympathetic activation.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Clonidine; Cold Temperature; Female; Heart Rate; Humans; Male; Norepinephrine; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-1; Sympathetic Nervous System; Theophylline; Vasoconstriction; Vasodilator Agents | 1999 |
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes.
Topics: Animals; Cimetidine; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Lidocaine; Microsomes, Liver; Midazolam; Neuromuscular Depolarizing Agents; Pentobarbital; Pharmacogenetics; Premedication; Rats; Theophylline; Thiamylal | 2005 |
A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
Topics: Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Female; Humans; Models, Biological; Paroxetine; Pregnancy; Theophylline | 2013 |
The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anticonvulsants; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pentylenetetrazole; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-2; Seizures; Theophylline; Yohimbine | 2014 |
Evaluation of tizanidine as a marker of canine CYP1A2 activity.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzoflavones; Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dogs; Enrofloxacin; Female; Fluoroquinolones; Microsomes, Liver; Molecular Probes; Phenacetin; Substrate Specificity; Theophylline | 2016 |
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers.
Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline | 2016 |