clonidine has been researched along with substance p in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (27.27) | 18.7374 |
| 1990's | 14 (42.42) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 4 (12.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eide, K; Hole, K | 1 |
| Hylden, JK; Kitto, K; Lei, S; Roerig, SC; Wilcox, GL | 1 |
| Hama, AT; Nakata, Y; Segawa, T | 1 |
| Fukuda, H; Mishima, A; Ono, H; Ono, S; Vasko, MR | 1 |
| Lambracht-Hall, M; Marathias, K; Savala, J; Theoharides, TC | 1 |
| Chahl, LA | 1 |
| Jones, RS; Olpe, HR | 1 |
| Gordh, T; Olsson, Y; Post, C | 1 |
| Nance, PW; Sawynok, J | 1 |
| Hedqvist, P; von Euler, US | 1 |
| Collier, HO; Tucker, JF | 1 |
| Barthó, L; Holzer, P; Lembeck, F | 1 |
| Kaniucki, MD; Perec, CJ; Stefano, FJ | 1 |
| Jurna, I | 1 |
| Ally, A; Meintjes, AF; Mitchell, JH; Wilson, LB | 1 |
| Chen, IJ; Chen, SJ; Lo, YC; Wu, JR; Yang, JM; Yeh, JL | 1 |
| Advenier, C; Biyah, K | 1 |
| Chen, IJ; Chen, IS; Chen, SJ; Lo, YC; Wu, BN; Yeh, JL | 1 |
| Bedard, PJ; Tremblay, LE | 1 |
| Galligan, JJ | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Luo, L; Wiesenfeld-Hallin, Z | 1 |
| Andell, S; Bartfai, T; Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Fairbanks, CA; Kitto, KF; Nguyen, HO; Posthumus, IJ; Stone, LS; Wilcox, GL | 1 |
| James, AN; Parkman, HP; Ryan, JP | 1 |
| Hendry, IA; Lacey, G; Morton, CR; Zhao, ZQ | 1 |
| Eisenach, JC; Fairbanks, CA; Kitto, KF; Stone, LS; Wilcox, GL | 1 |
| Christianson, CA; Hua, XY; Nazarian, A; Yaksh, TL | 1 |
| Chabot-Doré, AJ; Fairbanks, CA; Kitto, KF; Overland, AC; Rothwell, PE; Stone, LS; Wilcox, GL | 1 |
| Gong, H; Li, Z; Liu, G; Liu, H; Liu, Z; Yang, X | 1 |
| Gong, H; Li, Z; Liu, G; Liu, Q; Liu, Z; Yang, X | 1 |
| Chabot-Doré, AJ; Millecamps, M; Stone, LS | 1 |
| Chabot-Doré, AJ; Devost, D; Diatchenko, L; Fairbanks, CA; Hébert, TE; Millecamps, M; Naso, L; Piltonen, M; Stone, LS; Trieu, P; Wilcox, GL | 1 |
1 review(s) available for clonidine and substance p
| Article | Year |
|---|---|
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pertussis Vaccine; Scopolamine; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Yohimbine | 1984 |
32 other study(ies) available for clonidine and substance p
| Article | Year |
|---|---|
Interactions between substance P and norepinephrine in the regulation of nociception in mouse spinal cord.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Drug Interactions; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Norepinephrine; Pain Measurement; Skin Temperature; Spinal Cord; Substance P; Time Factors | 1992 |
Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1992 |
Clonidine reduces substance P binding in rat spinal cord membrane preparation.
Topics: Animals; Brain; Clonidine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1991 |
Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; In Vitro Techniques; Male; Parasympatholytics; Piperoxan; Prazosin; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Veratridine; Yohimbine | 1991 |
Endogenous regulation of rat brain mast cell serotonin release.
Topics: Animals; beta-N-Acetylhexosaminidases; Brain; Calcium; Capsaicin; Cells, Cultured; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; In Vitro Techniques; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Potassium; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1991 |
The properties of the clonidine withdrawal response of guinea-pig isolated ileum.
Topics: Animals; Atropine; Clonidine; Drug Interactions; Enkephalin, Methionine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Muscle Contraction; Norepinephrine; Phentolamine; Substance P; Substance Withdrawal Syndrome; Yohimbine | 1985 |
Pharmacological characterization of the receptor mediating the adrenergic inhibition of responses to substance P in the cingulate cortex.
Topics: Albuterol; Animals; Clonidine; Dopamine; Epinephrine; Gyrus Cinguli; Male; Norepinephrine; Phentolamine; Phenylephrine; Practolol; Prazosin; Rats; Receptors, Adrenergic, beta; Substance P | 1986 |
Evaluation of the toxicity of subarachnoid clonidine, guanfacine, and a substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Evaluation, Preclinical; Guanfacine; Guanidines; Injections, Spinal; Male; Microscopy, Electron; Phenylacetates; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Nerve Roots; Substance P | 1986 |
Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone.
Topics: Analgesia; Animals; Clonidine; Kinetics; Male; Morphine; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Time Factors; Yohimbine | 1987 |
Effects of substance P on the response of guinea pig vas deferens to transmural nerve stimulation.
Topics: Animals; Clonidine; Depression, Chemical; Electric Stimulation; Evoked Potentials; Guinea Pigs; Male; Phentolamine; Prostaglandins; Stimulation, Chemical; Substance P; Vas Deferens | 1974 |
Sympathetic control of substance P releasing enteric neurones in the guinea pig ileum.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; Guinea Pigs; Ileum; Neurosecretion; Norepinephrine; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Sincalide; Substance P; Sympathetic Nervous System | 1983 |
Clonidine inhibits salivary secretion by activation of postsynaptic alpha 2-receptors.
Topics: Animals; Clonidine; Female; Methacholine Compounds; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Salivation; Submandibular Gland; Substance P; Yohimbine | 1984 |
Pain-depressing agents and the spinal nociceptive system.
Topics: Analgesics; Animals; Ceruletide; Clonidine; Diazepam; Endorphins; Humans; Morphine; Motor Neurons; Neurons, Afferent; Nociceptors; Pentobarbital; Receptors, GABA-A; Receptors, Opioid; Reflex; Sincalide; Spinal Cord; Substance P; Synapses | 1984 |
Effects of clonidine on the reflex cardiovascular responses and release of substance P during muscle contraction.
Topics: Analysis of Variance; Animals; Blood Pressure; Cats; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Rate; Kidney; Male; Microdialysis; Muscle Contraction; Muscles; Spinal Cord; Substance P; Time Factors | 1994 |
Autonomic and sensory cardiovascular activities of nonivamide: intrathecal administration of clonidine.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Capsaicin; Cardiovascular System; Clonidine; Heart Rate; Infusions, Parenteral; Injections, Intra-Arterial; Injections, Intravenous; Male; Neurons, Afferent; Rats; Rats, Wistar; Spine; Substance P; Vanillic Acid | 1994 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
C-fiber-evoked autonomic cardiovascular effects after injection of Piper betle inflorescence extracts.
Topics: Animals; Areca; Atropine; Blood Pressure; Capsaicin; Chromatography, High Pressure Liquid; Clonidine; Eugenol; Heart Rate; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Injections, Subcutaneous; Male; Plant Extracts; Plants, Medicinal; Propranolol; Rats; Rats, Wistar; Safrole; Substance P; Vagotomy | 1995 |
Action of 5-hydroxytryptamine, substance P, thyrotropin releasing hormone and clonidine on spinal neuron excitability.
Topics: 5-Hydroxytryptophan; Animals; Clonidine; Electromyography; Female; Motor Neurons; Muscle Spasticity; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; Synaptic Transmission; Thyrotropin-Releasing Hormone | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
N-acetyl beta-endorphin-(1-31) and substance P regulate the supraspinal antinociception mediated by mu opioid and alpha-2 adrenoceptors but not by delta opioid receptors in the mouse.
Topics: Analgesics; Animals; beta-Endorphin; Clonidine; Male; Mice; Peptide Fragments; Receptors, Adrenergic, alpha; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P | 1993 |
Low-dose intrathecal clonidine releases tachykinins in rat spinal cord.
Topics: Animals; Biphenyl Compounds; Clonidine; Decerebrate State; Hypnotics and Sedatives; Injections, Spinal; Neurokinin A; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Substance P | 1993 |
The effects of intrathecal galanin message-associated peptide (GMAP) on the flexor reflex in rats.
Topics: Analgesics, Opioid; Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Female; Galanin; Injections, Spinal; Morphine; Nerve Fibers; Neurons, Afferent; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Cord; Substance P; Sympatholytics; Vasoactive Intestinal Peptide | 1995 |
alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy.
Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Drug Synergism; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Oligonucleotides, Antisense; Oligopeptides; Pain Measurement; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Spinal Cord; Substance P; Sympathetic Nervous System | 2002 |
Effects of clonidine and tricyclic antidepressants on gastric smooth muscle contractility.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Antidepressive Agents, Tricyclic; Clonidine; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Stomach; Substance P | 2004 |
Substance P release in the cat spinal cord upon afferent C-fibre stimulation is not attenuated by clonidine at analgesic doses.
Topics: Afferent Pathways; Analgesics; Animals; Cats; Clonidine; Dose-Response Relationship, Drug; Down-Regulation; Electric Stimulation; Lidocaine; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Presynaptic Terminals; Spinal Cord; Substance P; Synaptic Transmission | 2004 |
ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Back Pain; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Mice; Point Mutation; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P | 2007 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-1; Substance P | 2008 |
Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Calcitonin Gene-Related Peptide; Clonidine; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; Female; Hyperalgesia; In Vitro Techniques; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Oligopeptides; Patch-Clamp Techniques; Posterior Horn Cells; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, delta; Signal Transduction; Spinal Cord; Substance P; Tetrodotoxin | 2009 |
Effects of acute exposure of alpha 1- and alpha 2-adrenoreceptor agonist or antagonist on capsaicin-evoked substance P release from dorsal root ganglion neurons in vitro.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Capsaicin; Cells, Cultured; Clonidine; Ganglia, Spinal; Neurons; Phenylephrine; Prazosin; Radioimmunoassay; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Yohimbine | 2010 |
Effects of selective alpha 2-adrenoreceptor stimulation on capsaicin-evoked substance P release from primary cultured dorsal root ganglion neurons.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Capsaicin; Cells, Cultured; Clonidine; Ganglia, Spinal; Neurons; Radioimmunoassay; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; TRPV Cation Channels; Yohimbine | 2010 |
The delta-opioid receptor is sufficient, but not necessary, for spinal opioid-adrenergic analgesic synergy.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Spinal; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P | 2013 |
Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Allosteric Regulation; Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Injections, Spinal; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Nociceptive Pain; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P | 2015 |