clonidine has been researched along with pirenzepine in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Grammatté, T; Schentke, KU; Strohbach, C | 1 |
| Chiba, S; Furukawa, Y; Nakane, T | 1 |
| Gatti, G; Madeddu, L; Meldolesi, J; Pandiella, A; Pozzan, T | 1 |
| Iwai, S; Shirakawa, J; Tanaka, C; Taniyama, K | 1 |
| Giachetti, A; Micheletti, R; Montagna, E | 1 |
| Brianda, S; Delitala, G; Maioli, M; Mannelli, M; Pacifico, A; Palermo, M | 1 |
| Nakamura, K; Okuma, Y; Osumi, Y; Yokotani, K | 1 |
| Dehpour, AR; Delfan, A; Mortazavi, SR; Mousavizadeh, K | 1 |
| Bouaziz, H; Detweiler, DJ; Eisenach, JC; Li, P; Lothe, A; Tong, C; Yoon, Y | 1 |
| Grottick, AJ; Herberg, LJ; Montgomery, AM | 1 |
| Ando, S; Harasawa, I; Honda, K; Kamiya, HO; Koga, K; Takano, Y | 1 |
1 trial(s) available for clonidine and pirenzepine
| Article | Year |
|---|---|
[The effect of various non-ulcer pharmaceuticals on nocturnal gastric pH in healthy subjects].
Topics: Adult; Chlorprothixene; Circadian Rhythm; Clonidine; Female; Gastric Juice; Humans; Hydrogen-Ion Concentration; Ketotifen; Male; Nifedipine; Pirenzepine; Single-Blind Method; Stimulation, Chemical | 1991 |
17 other study(ies) available for clonidine and pirenzepine
| Article | Year |
|---|---|
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Anti-muscarinic effect of alinidine on acetylcholine-induced vasodilation in isolated and perfused dog coronary arteries.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Coronary Vessels; Dogs; Female; In Vitro Techniques; Male; Parasympatholytics; Piperidines; Pirenzepine; Vasodilation | 1991 |
Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals.
Topics: Animals; Calcium; Carbachol; Cell Differentiation; Cell Line; Clonidine; Cyclic AMP; Imidazoles; Nerve Growth Factors; Phenylisopropyladenosine; Pheochromocytoma; Pirenzepine; Rats; Tumor Cells, Cultured | 1988 |
Regulation of [3H]GABA release from strips of guinea pig urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Baclofen; Bicuculline; Clonazepam; Clonidine; Female; gamma-Aminobutyric Acid; Guinea Pigs; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscimol; Pentobarbital; Phenylephrine; Pirenzepine; Potassium; Prazosin; Tritium; Urinary Bladder; Yohimbine | 1988 |
Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist.
Topics: Animals; Atrial Function; Benzodiazepinones; Binding, Competitive; Cats; Clonidine; Dogs; Female; Guinea Pigs; Heart; Heart Atria; Heart Rate; Ileum; In Vitro Techniques; Kinetics; Male; Mice; Muscle, Smooth; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stomach; Sympatholytics; Urinary Bladder | 1986 |
Cholinergic receptor control mechanisms for L-dopa, apomorphine, and clonidine-induced growth hormone secretion in man.
Topics: Adult; Apomorphine; Benzodiazepinones; Clonidine; Growth Hormone; Humans; Kinetics; Levodopa; Male; Parasympatholytics; Pirenzepine; Prolactin; Receptors, Cholinergic | 1983 |
Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Calcium; Clonidine; Diamines; Drug Interactions; Electric Stimulation; Gastric Mucosa; Hexamethonium; Hexamethonium Compounds; Male; Muscarinic Antagonists; Oxotremorine; Parasympatholytics; Perfusion; Phenylephrine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Stomach; Sympathetic Nervous System; Tetrodotoxin; Vagus Nerve | 1993 |
Effects of atropine, pirenzepine, clonidine, and morphine on biphasic response of rat gastric fundus to field stimulation.
Topics: Animals; Atropine; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Fundus; In Vitro Techniques; Male; Morphine; Muscle Contraction; Pirenzepine; Rats; Rats, Sprague-Dawley | 1994 |
Spinal cholinergic alpha-2 adrenergic interactions in analgesia and hemodynamic control: role of muscarinic receptor subtypes and nitric oxide.
Topics: Analgesia; Animals; Clonidine; Female; Hemodynamics; Neostigmine; Nitric Oxide; Pirenzepine; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Sheep; Spinal Cord | 1994 |
Alpha2-adrenoceptor antagonism is neither sufficient nor necessary for the distinctive action of atypical neuroleptics on intracranial self-stimulation in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Clonidine; Haloperidol; Idazoxan; Male; Motivation; Olanzapine; Pirenzepine; Rats; Receptors, Adrenergic, alpha-2; Self Stimulation | 2003 |
Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesics; Animals; Atropine; Blood Glucose; Clonidine; Diabetes Mellitus, Experimental; Diamines; Injections, Spinal; Male; Mice; Motor Activity; Muscarinic Agonists; Muscarinic Antagonists; Pain; Pain Threshold; Piperidines; Pirenzepine; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Spinal Cord; Streptozocin; Stress, Mechanical; Time Factors | 2004 |