clonidine and paroxetine

clonidine has been researched along with paroxetine in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's2 (10.00)18.2507
2000's11 (55.00)29.6817
2010's6 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Brunello, N; Galimberti, R; Racagni, G; Riva, M; Rovescalli, AC1
Arora, RC; Crayton, J; Gulati, A1
Baker, GB; Bourin, M; Colombel, MC; Redrobe, JP1
Berger, M; Billiard, M; Chalabreysse, M; Durst, P; Palazzolo, J; Peyrelong, JP; Vialle, A1
Bourin, M; Hascoët, M; Massé, F1
Elliott, PM; Frenneaux, MP; McKenna, WJ; Mist, B; Murphy, RT; Shah, JS; Thaman, R; Williams, L1
Baber, R; Hickey, M; Kwik, M1
Alexander, IM; Moore, A1
Isoherranen, N; Ke, AB; Nallani, SC; Rostami-Hodjegan, A; Unadkat, JD; Zhao, P1

Reviews

3 review(s) available for clonidine and paroxetine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Therapy for menopausal symptoms during and after treatment for breast cancer : safety considerations.
    Drug safety, 2005, Volume: 28, Issue:12

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Case-Control Studies; Clonidine; Estrogen Receptor Modulators; Estrogen Replacement Therapy; Female; Health Behavior; Hot Flashes; Humans; Menopause; Norpregnenes; Paroxetine; Personal Health Services; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Tamoxifen

2005
Treating vasomotor symptoms of menopause: the nurse practitioner's perspective.
    Journal of the American Academy of Nurse Practitioners, 2007, Volume: 19, Issue:3

    Topics: Adrenergic alpha-Agonists; Algorithms; Amines; Citalopram; Clonidine; Complementary Therapies; Cyclohexanecarboxylic Acids; Estrogen Replacement Therapy; Evidence-Based Medicine; Female; Fluoxetine; Gabapentin; gamma-Aminobutyric Acid; Hot Flashes; Humans; Life Style; Menopause; Middle Aged; Nurse Practitioners; Paroxetine; Patient Education as Topic; Patient Selection; Practice Guidelines as Topic; Primary Health Care; Safety Management; Selective Serotonin Reuptake Inhibitors

2007

Trials

1 trial(s) available for clonidine and paroxetine

ArticleYear
Reversal of inappropriate peripheral vascular responses in hypertrophic cardiomyopathy.
    Journal of the American College of Cardiology, 2005, Sep-06, Volume: 46, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiomyopathy, Hypertrophic, Familial; Clonidine; Cross-Over Studies; Double-Blind Method; Exercise Test; Female; Humans; Lower Extremity; Male; Paroxetine; Propranolol; Syncope, Vasovagal; Vasodilation

2005

Other Studies

16 other study(ies) available for clonidine and paroxetine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:3

    Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imipramine; Ketanserin; Kinetics; Male; Paroxetine; Piperidines; Prazosin; Proteins; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Time Factors

1988
Central serotonergic uptake mechanisms in hypertensive rats: effects of clonidine and centhaquin.
    European journal of pharmacology, 1993, Feb-09, Volume: 231, Issue:2

    Topics: Animals; Binding, Competitive; Blood Pressure; Brain Chemistry; Brain Stem; Cell Membrane; Cerebral Cortex; Clonidine; Heart Rate; Hypertension; Imipramine; Neurons; Paroxetine; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Serotonin; Serotonin

1993
Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms.
    Journal of psychopharmacology (Oxford, England), 1998, Volume: 12, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Animals; Antidepressive Agents; Apomorphine; Brain; Clonidine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Indoles; Male; Mice; Motor Activity; Norepinephrine; Paroxetine; Pindolol; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming

1998
[Methadone and sleep apnea syndrome].
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:3

    Topics: Adult; Brain; Clonidine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Hydroxyzine; Methadone; Methotrimeprazine; Opioid-Related Disorders; Paroxetine; Polysomnography; Sleep Apnea, Central; Sleep Stages; Substance Withdrawal Syndrome; Trimeprazine

2005
alpha2-Adrenergic agonists antagonise the anxiolytic-like effect of antidepressants in the four-plate test in mice.
    Behavioural brain research, 2005, Oct-14, Volume: 164, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Citalopram; Clonidine; Cyclohexanols; Cyclopropanes; Dose-Response Relationship, Drug; Drug Antagonism; Guanabenz; Male; Mice; Milnacipran; Motor Activity; Paroxetine; Punishment; Selective Serotonin Reuptake Inhibitors; Statistics, Nonparametric; Venlafaxine Hydrochloride

2005
A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Clonidine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Female; Humans; Models, Biological; Paroxetine; Pregnancy; Theophylline

2013