clonidine and pargyline

clonidine has been researched along with pargyline in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199015 (55.56)18.7374
1990's4 (14.81)18.2507
2000's1 (3.70)29.6817
2010's6 (22.22)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chen, J; Chen, X; Huang, L; Li, X; Sun, Y1
Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W1
Jiang, N; Kong, LY; Lan, JS; Li, F; Wang, J; Wang, X; Wang, ZM; Wu, JJ; Xie, SS1
Cai, P; Kong, LY; Li, F; Liu, QH; Wang, J; Wang, XB; Wu, JJ; Yang, HL; Yang, XL1
Cai, P; Fang, SQ; Kong, LY; Liu, QH; Tang, YW; Wang, C; Wang, XB; Yang, HL; Yang, XL1
Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J1
Huang, M; Jiang, N; Kong, LY; Lan, JS; Wang, XB; Yin, FC1
Offermeier, J; Potgieter, B1
Hicks, PE; Langer, SZ; Macrae, AD1
MacDonald, E; Scheinin, H; Scheinin, M1
Simson, PG; Weiss, JM1
Dougan, DF; Duffield, AM; Duffield, PH; Wade, DN1
Biziere, K; Gonon, F; Mermet, C; Steinberg, R; Suaud-Chagny, MF1
Aronstam, RS; Buccafusco, JJ; Graham, JH1
Altar, CA; Kim, HS; Wood, PL1
Vidt, DG1
Papeschi, R1
Malmnäs, CO1
Dhasmana, KM; Fokker, WA; Spilker, BA1
Dubocovich, ML; Langer, SZ; Pelayo, F1
Sugrue, MF1
Enero, MA; Gutkind, JS1
Amabeoku, G; Chandomba, R1
Brun, P; Buda, M; Gonon, F; Suaud-Chagny, MF1
Amabeoku, GJ1
Nott, MW; Rand, MJ; Thaina, P1

Reviews

1 review(s) available for clonidine and pargyline

ArticleYear
Choice of antihypertensive drugs for the treatment of hypertension, including hypertensive emergencies.
    Cardiovascular clinics, 1974, Volume: 6, Issue:2

    Topics: Antihypertensive Agents; Bethanechol Compounds; Clonidine; Diazoxide; Diuretics; Emergencies; Ferricyanides; Ganglionic Blockers; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Muscle, Smooth; Pargyline; Propranolol; Secologanin Tryptamine Alkaloids; Sodium Chloride Symporter Inhibitors; Vasodilator Agents

1974

Other Studies

26 other study(ies) available for clonidine and pargyline

ArticleYear
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
    Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

    Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine

2013
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
    European journal of medicinal chemistry, 2015, May-05, Volume: 95

    Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine

2015
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2016, Apr-01, Volume: 24, Issue:7

    Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Donepezil; Dose-Response Relationship, Drug; Drug Design; Eels; Humans; Indans; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Structure-Activity Relationship

2016
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Male; Mice; Mice, Inbred Strains; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; PC12 Cells; Protein Aggregates; Rats; Structure-Activity Relationship

2017
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Humans; Hydrogen Peroxide; Imines; Ligands; Lipopolysaccharides; Mice; Microglia; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Peptide Fragments; Protein Aggregates; Rats; Salicylates; Structure-Activity Relationship

2017
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea

2018
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
    RSC medicinal chemistry, 2020, Feb-01, Volume: 11, Issue:2

    Topics:

2020
Some effects of fenfluramine and its derivatives on the central catecholaminergic systems of mice.
    Postgraduate medical journal, 1975, Volume: 51 Suppl 1

    Topics: Animals; Apomorphine; Clonidine; Fenfluramine; Male; Methyltyrosines; Mice; Motor Activity; Norfenfluramine; Pargyline; Reserpine

1975
Differential blocking actions of idazoxan against the inhibitory effects of 6-fluoronoradrenaline and clonidine in the rat vas deferens.
    British journal of pharmacology, 1985, Volume: 86, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cocaine; Dioxanes; Dioxins; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pargyline; Rats; Reserpine; Vas Deferens

1985
Comparison of free MHPG in rat cerebrospinal fluid with free and conjugated MHPG in brain tissue: effects of drugs modifying noradrenergic transmission.
    European journal of pharmacology, 1986, Sep-23, Volume: 129, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Brain Chemistry; Clonidine; Glycols; Imidazoles; Male; Methoxyhydroxyphenylglycol; Methyltyrosines; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Reserpine; Synaptic Transmission

1986
Depression in an animal model: focus on the locus ceruleus.
    Ciba Foundation symposium, 1986, Volume: 123

    Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Clonidine; Depression; Electroshock; Locus Coeruleus; Norepinephrine; Pargyline; Piperoxan; Receptors, Adrenergic, alpha; Stress, Physiological

1986
Effect of chlordimeform and clonidine on the turnover of P-octopamine in rat hypothalamus and striatum.
    Life sciences, 1986, Apr-07, Volume: 38, Issue:14

    Topics: Amidines; Animals; Chlorphenamidine; Clonidine; Corpus Striatum; Hypothalamus; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Octopamine; Pargyline; Rats; Rats, Inbred Strains; Tyramine

1986
In vivo voltammetric monitoring of catecholamine metabolism in the A1 and A2 regions of the rat medulla oblongata.
    Journal of neurochemistry, 1986, Volume: 47, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Catecholamines; Clonidine; Dopamine; Electrochemistry; Hydroxydopamines; Kinetics; Male; Medulla Oblongata; Methoxyhydroxyphenylglycol; Methyltyrosines; Norepinephrine; Oxidopamine; Pargyline; Rats; Tissue Distribution

1986
Role of central biogenic amines on the protection afforded by clonidine against the toxicity of soman, an irreversible cholinesterase inhibitor.
    Toxicology letters, 1988, Volume: 42, Issue:3

    Topics: Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Clonidine; Mice; Pargyline; Reserpine; Soman

1988
In vivo assessment of dopamine and norepinephrine release in rat neocortex: gas chromatography-mass spectrometry measurement of 3-methoxytyramine and normetanephrine.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: Animals; Cerebral Cortex; Clonidine; Dopamine; Gas Chromatography-Mass Spectrometry; Haloperidol; Male; Nomifensine; Norepinephrine; Normetanephrine; Pargyline; Rats; Rats, Inbred Strains

1987
An investigation on the behavioral and hypothermic effects of yohimbine: interaction with drugs affecting central and peripheral monoamines.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 208, Issue:1

    Topics: 5-Hydroxytryptophan; Aggression; Amphetamine; Animals; Apomorphine; Atropine; Behavior, Animal; Benserazide; Biogenic Amines; Body Temperature; Catecholamines; Chlorisondamine; Clonidine; Depression, Chemical; Dihydroxyphenylalanine; Fenclonine; Haloperidol; Humans; Lysergic Acid Diethylamide; Male; Methysergide; Motor Activity; Pargyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Stereotyped Behavior; Yohimbine

1974
Opposite effects of serotonin and dopamine on copulatory activation in castrated male rats.
    Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0

    Topics: Adrenal Glands; Adrenalectomy; Animals; Apomorphine; Carboxy-Lyases; Castration; Catecholamines; Clonidine; Dopamine; Female; Fenclonine; Lysergic Acid Diethylamide; Male; Methyltyrosines; Motor Activity; Ovary; Pargyline; Pimozide; Rats; Serotonin; Serotonin Antagonists; Sexual Behavior, Animal; Synaptic Transmission; Testis; Testosterone

1974
Peripheral cardiovascular effects, in the pithed rat, of compounds used in the treatment of hypertension.
    British journal of pharmacology, 1972, Volume: 46, Issue:3

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cordotomy; Diazoxide; Electric Stimulation; Ergotamine; Guanethidine; Hydrochlorothiazide; Iproniazid; Male; Mecamylamine; Methyldopa; Pargyline; Phenobarbital; Rats; Reserpine; Sympathetic Nervous System; Thiocyanates; Trimethaphan

1972
Inhibition of neuronal uptake reduces the presynaptic effects of clonidine but not of alpha-methylnoradrenaline on the stimulation-evoked release of 3H-noradrenaline from rat occipital cortex slices.
    European journal of pharmacology, 1980, Jun-13, Volume: 64, Issue:2-3

    Topics: Amphetamine; Animals; Cerebral Cortex; Clonidine; Cocaine; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; In Vitro Techniques; Male; Nordefrin; Norepinephrine; Pargyline; Phentolamine; Rats; Receptors, Adrenergic, alpha; Tritium

1980
A study of the sensitivity of rat brain alpha 2-adrenoceptors during chronic antidepressant treatments.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:2

    Topics: Animals; Antidepressive Agents; Brain Chemistry; Cerebral Cortex; Clonidine; Desipramine; Dihydroalprenolol; Electroshock; Male; Methoxyhydroxyphenylglycol; Pargyline; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha

1982
Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:3

    Topics: Animals; Blood Pressure; Clonidine; Clorgyline; Female; Heart Rate; Pargyline; Propylamines; Rats; Rats, Inbred Strains

1984
Strychnine-induced seizures in mice: the role of noradrenaline.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipramine; Male; Mice; Pargyline; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic; Reserpine; Seizures; Strychnine

1994
In vivo noradrenaline release evoked in the anteroventral thalamic nucleus by locus coeruleus activation: an electrochemical study.
    Neuroscience, 1993, Volume: 52, Issue:4

    Topics: Animals; Axons; Clonidine; Desipramine; Electric Stimulation; Electrochemistry; Evoked Potentials; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Norepinephrine; Oxidation-Reduction; Pargyline; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thalamic Nuclei; Yohimbine

1993
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
    Experientia, 1993, Oct-15, Volume: 49, Issue:10

    Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Droxidopa; Drug Synergism; Idazoxan; Imipramine; Male; Methyltyrosines; Mice; Norepinephrine; Pargyline; Phentolamine; Physostigmine; Prazosin; Reserpine; Seizures; Serotonin

1993
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
    Journal of autonomic pharmacology, 1999, Volume: 19, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Stimulation; Female; Heart Atria; Heart Rate; Idazoxan; Imidazoles; In Vitro Techniques; Muscle Contraction; Norepinephrine; Pargyline; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors

1999