clonidine has been researched along with oxazoles in 120 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (31.67) | 18.7374 |
| 1990's | 55 (45.83) | 18.2507 |
| 2000's | 22 (18.33) | 29.6817 |
| 2010's | 5 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobinger, W; Pichler, L | 2 |
| Hamilton, CA; Howie, CA; Reid, JL; Yakubu, MA | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Feldman, J; Greney, H; Stutzmann, J; Tibirica, E | 1 |
| Cerutti, C; Koenig-Bérard, E; Sannajust, F; Sassard, J | 1 |
| Head, GA; Sannajust, F | 2 |
| Bousquet, P; Gonon, F; Mermet, C; Suaud-Chagny, MF; Tibiriça, E | 1 |
| Ernsberger, P; Feinland, G; Gomez, RE; Reis, DJ | 1 |
| Deckert, V; Elghozi, JL; Lachaud, V; Parini, A | 1 |
| Bousquet, P; Feldman, J; Gonon, F; Mermet, C; Monassier, L; Tibiriça, E | 1 |
| Frutoso, J; Geelen, G; Ghaemmaghami, F; Gharib, C; Ibanez, J; Vincent, M | 1 |
| Burke, S; Head, GA | 1 |
| Smits, JF; Struyker-Boudier, HA | 1 |
| De Mey, JG; Eerdmans, PH; Struyker Boudier, HA | 1 |
| Hamilton, CA; Howie, CA; Jardine, E; Reid, JL; Yakubu, MA | 1 |
| Dresse, A; Scuvée-Moreau, J | 1 |
| Doyle, AE; Jarrott, B; Lewis, SJ | 2 |
| Li, CG; Rand, MJ | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Feldman, J; Molines, A; Tibirica, E | 1 |
| Dinh Xuan, AT; Lockhart, A | 1 |
| Coupry, I; Koenig, E; Lachaud, V; Parini, A; Podevin, RA | 1 |
| Barrès, C; Cerutti, C; Julien, C; Koenig-Bérard, E; Sannajust, F; Sassard, J | 1 |
| Carenzi, A; Chiarino, D; Napoletano, M; Reggiani, A; Sala, A; Sala, R | 1 |
| de Jonge, A; Jonkman, FA; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| Al-Damluji, S; Besser, GM; Grossman, A; Turner, P; Weerasuriya, K | 1 |
| Beau, B; Delbarre, G; Koenig-Berard, E; Labrid, C; Lhoste, F; Tierney, C | 1 |
| Dresse, A; Scuvée-Moreau, J; Seutin, V | 1 |
| Koenig-Berard, E; Nadaud, D; Stinus, L; Tierney, C | 1 |
| Doyle, AE; Jarrott, B; Lewis, SJ; Louis, WJ | 1 |
| Clerici, C; Harf, A; Macquin-Mavier, I | 1 |
| Van Zwieten, PA | 1 |
| Fillastre, JP; Galinier, F; Le Bihan, G; Letac, B; Schwartz, J | 1 |
| Bourreau, JP; Tricoche, R | 1 |
| Advenier, C; Dinh Xuan, AT; Lockhart, A; Matran, R; Regnard, J; Vitou, P | 1 |
| Herman, AG; Jordaens, FH; Verbeuren, TJ; Zonnekeyn, LL | 1 |
| Coupry, I; Dausse, JP; Koenig, E; Lachaud, V; Parini, A; Podevin, RA | 1 |
| Beau, B; Begue, JM; Bromet, N; Du Vignaud, P; Genissel, P; Grislain, L; Guillouzo, A; Mocquard, MT; Ratanasavanh, D | 1 |
| Enna, SJ; Zorn, SH | 1 |
| Schmitt, H; Tsoucaris-Kupfer, D | 1 |
| Schümann, HJ; Starke, K; Werner, U | 1 |
| Le Douarec, JC; Petillot, N; Schmitt, H | 1 |
| Shaw, E; Turner, P; Weerasuriya, K | 1 |
| Boucher, T; Dostert, P; Guffroy, C; Strolin Benedetti, M | 1 |
| Hammer, R; Kobinger, W; Pichler, L | 1 |
| Kobinger, W; Lillie, C; Pichler, L | 1 |
| Timmermans, PB; Van Zwieten, PA | 1 |
| Jarrott, B; Louis, WJ; Summers, RJ | 1 |
| Becker, H; Dietz, R; Ganten, D; Lang, RE; Rettig, R; Schömig, A; Schwab, NA; Unger, T | 1 |
| Costa, LG; Murphy, SD | 1 |
| Benedikter, L; Mey, T; Middleton, DA | 1 |
| Dampney, RA; Li, YW | 1 |
| Advenier, C; Biyah, K | 1 |
| Combes-George, M; Mory, G; Nechad, M; Parini, A; Tesson, F | 1 |
| Elliott, HL; MacPhee, G; Panfilov, V; Reid, JL | 1 |
| Gundlach, AL; King, PR; Louis, WJ | 2 |
| Handley, SL; Jackson, HC; Jordan, S; Nutt, DJ | 1 |
| García-Sevilla, JA; Pineda, J; Ugedo, L | 1 |
| Hamilton, CA; Jardine, E; Reid, JL | 1 |
| Godwin, SJ; Head, GA; Sannajust, F | 1 |
| Christen, MO; Collins, LA; Dreshaj, I; Ernsberger, P; Graff, LM; Graves, ME; Grove, DL; Haxhiu, MA; Schäfer, SG | 1 |
| Christen, O; Göthert, M; Molderings, GJ; Schäfer, SG | 1 |
| Janssen, BJ; Oosting, J; Struyker-Boudier, HA; Tyssen, CM | 1 |
| Boucher, M; Chassaing, C; Dubar, M; Duchêne-Marullaz, P; Vivet, P | 1 |
| Bousquet, P; Bricca, G; Dontenwill, M; Tibiriça, E | 1 |
| Chan, CK; Head, GA; Sannajust, F | 1 |
| Harron, DW; Hasson, B; King, DJ; McClelland, RJ; Regan, M | 1 |
| Gargalidis-Moudanos, C; Parini, A | 1 |
| Boucher, M; Chapuy, E; Chassaing, C; Dubar, M | 2 |
| Fröhlich, R; Illes, P; Szabo, B | 1 |
| Chan, CK; Head, GA | 1 |
| Chayvialle, JA; Chéry-Croze, S; Détolle-Sarbach, S; Guez, D; Miampamba, M | 1 |
| Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM | 1 |
| Millan, MJ | 1 |
| Piletz, JE; Reis, DJ | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Ali, A; Cheng, HY; Ting, KN; Wilson, VG | 1 |
| Kunduzova, OR; Medvedev, OS; Medvedeva, NA; Murashev, AN | 3 |
| Godwin, SJ; Head, GA; Parkin, ML; Tortelli, CF | 1 |
| Blue, DR; Dillon, MP; Eglen, RM; Jasper, JR; Lesnick, JD; MacLennan, SJ; Zhu, QM | 1 |
| Hébert, CA; Kudo, LH; Rouch, AJ | 1 |
| Drzewoski, J; Wiśniewska-Jarosińska, M | 1 |
| Bock, C; Niederhoffer, N; Nordheim, U; Szabo, B | 1 |
| Head, GA | 1 |
| Peters, SL; Van Zwieten, PA | 1 |
| Bousquet, P; Feldman, J; Pompermayer, K; Salgado, MC | 1 |
| Robles, NR | 1 |
| Gileadi, C; Hirashima, A; Kuwano, E; Rafaeli, A | 1 |
| Castro Resende, AC; Leão, MC; Lima, AF; Mesquita Ferreira, AG; Moreira, CF; Nunes, FR; Sena, KM; Silveira, SS; Soares de Moura, RS | 1 |
| Audinot, V; Boutin, JA; Cordi, A; Cussac, D; Dekeyne, A; Duqueyroix, D; Girardon, S; Lacoste, JM; Millan, MJ; Milligan, G; Mullot, J; Newman-Tancredi, A; Nicolas, JP; Renouard-Try, A | 1 |
| Auclair, A; Bosc, C; Brocco, M; Cordi, A; Dekeyne, A; Gobert, A; Lacoste, JM; Lejeune, F; Millan, MJ; Rivet, JM | 1 |
| Bousquet, P; Bruban, V; Feldman, J; Sy, GY | 1 |
| Fritz, T; Szabo, B; Wedzony, K | 1 |
| Bousquet, P | 1 |
| Bousquet, P; Catelli, M; Feldman, J; Tibirica, E | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Artigues-Varin, C; Mulder, P; Richard, V; Thuillez, C; Varin, R | 1 |
| Abdel-Rahman, AA; Li, G; Mao, L | 1 |
| Abelson, KS; Höglund, AU | 1 |
| Araújo, CV; Bousquet, P; Estato, V; Tibiriçá, E | 1 |
| Abdel-Rahman, AA; Li, G; Wang, X | 2 |
| Caillé, S; Georges, F; Le Moine, C; Stinus, L; Vouillac, C | 1 |
| Briaud, S; Sannajust, F; Zhang, BL | 1 |
| Ernsberger, P; Kossover, R; Previs, SF; Velliquette, RA | 1 |
| Abdel-Rahman, AA; Li, G | 1 |
| Sica, DA | 1 |
| Gyires, K; Zádori, Z | 1 |
| Abdel-Rahman, AA; Bender, TS | 1 |
| Al-Khrasani, M; Gyires, K; Mátyus, P; Mózes, MM; Pap, B; Shujaa, N; Zádori, ZS | 1 |
| Bousquet, P; Lessa, MA; Nascimento, AR; Sabino, B; Tibiriçá, E | 1 |
| Bakan, E; Borekci, B; Kumbasar, S; Kumtepe, Y; Salman, S; Suleyman, H; Yilmaz, M | 1 |
| Cornet, M; De Ron, P; Dedoncker, P; Delaunois, A; Depelchin, BO; Guyaux, M; Hanon, E; Jnoff, E; Rosseels, ML | 1 |
| Bousquet, P; Gomes, F; Gonçalves-de-Albuquerque, CF; Lessa, MA; Machado, MV; Nascimento, AR; Tibiriçá, E; Vieira, AB | 1 |
| Dantzler, HA; Kline, DD; Milanick, WJ; Polo-Parada, L | 1 |
11 review(s) available for clonidine and oxazoles
| Article | Year |
|---|---|
Imidazoline receptors. A new concept in central regulation of the arterial blood pressure.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Hypertension; Imidazoline Receptors; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1992 |
New concepts on the central regulation of blood pressure. Alpha 2-adrenoceptors and "imidazoline receptors".
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Brain; Clonidine; Humans; Imidazoles; Oxazoles; Receptors, Adrenergic, alpha; Rilmenidine | 1989 |
Bronchial effects of alpha 2-adrenoceptor agonists and of other antihypertensive agents in asthma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asthma; Bronchi; Calcium Channel Blockers; Clonidine; Humans; Hypertension; Oxazoles; Rilmenidine | 1989 |
Clinical pharmacology of drugs acting on imidazoline and adrenergic receptors. Studies with clonidine, moxonidine, rilmenidine, and atenolol.
Topics: Antihypertensive Agents; Atenolol; Clinical Trials as Topic; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Placebos; Receptors, Adrenergic; Receptors, Drug; Reference Values; Rilmenidine | 1995 |
[Imidazole receptors and blood pressure regulation. High receptor selectivity of moxonidine].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Humans; Hypertension; Imidazoles; Oxazoles; Rabbits; Rats; Receptors, Drug; Rilmenidine | 1993 |
[The imidazoline receptor and the central regulation of arterial pressure].
Topics: Blood Pressure; Catecholamines; Central Nervous System; Clonidine; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1993 |
The imidazoline receptor in control of blood pressure by clonidine and allied drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Humans; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Neurons; Oxazoles; Receptors, Drug; Rilmenidine | 1997 |
[Clinical pharmacology of hypotensive drugs acting on central imidazoline receptors].
Topics: Antihypertensive Agents; Clonidine; Drug Interactions; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1998 |
Central I1-imidazoline receptors as targets of centrally acting antihypertensive drugs. Clinical pharmacology of moxonidine and rilmenidine.
Topics: Animals; Antihypertensive Agents; Brain; Clinical Trials as Topic; Clonidine; Hemodynamics; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1999 |
I1 receptors, cardiovascular function, and metabolism.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Cardiovascular System; Clonidine; Humans; Hypertension; Imidazoline Receptors; Kidney; Oxazoles; Pancreas; Receptors, Drug; Rilmenidine; Treatment Outcome | 2001 |
Centrally acting antihypertensive agents: an update.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Oxazoles; Rilmenidine | 2007 |
6 trial(s) available for clonidine and oxazoles
| Article | Year |
|---|---|
Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Growth Hormone; Humans; Hydrocortisone; Male; Oxazoles; Rilmenidine | 1987 |
A multicenter double-blind comparative study of rilmenidine and clonidine in 333 hypertensive patients.
Topics: Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine | 1988 |
Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects.
Topics: Adrenergic alpha-Agonists; Adult; Asthma; Bronchi; Clonidine; Female; Forced Expiratory Volume; Histamine; Humans; Male; Oxazoles; Rilmenidine | 1988 |
Preliminary clinical pharmacological studies of S3341, a new hypotensive agent, and comparison with clonidine in normal males.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Blood Pressure; Central Nervous System; Clonidine; Dose-Response Relationship, Drug; Electrocardiography; Humans; Male; Oxazoles; Rilmenidine | 1984 |
Comparative study of the effect of azepexole and clonidine on blood pressure and pulse rate in normotensive subjects.
Topics: Adult; Azepines; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Oxazoles; Posture; Pulse | 1981 |
Effects of rilmenidine and clonidine on the electroencephalogram, saccadic eye movements, and psychomotor function.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials, Auditory; Heart Rate; Humans; Male; Oxazoles; Placebos; Psychomotor Performance; Rilmenidine; Saccades | 1995 |
103 other study(ies) available for clonidine and oxazoles
| Article | Year |
|---|---|
Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8,-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the "clonidine-type".
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Azepines; Cardiac Output; Cats; Central Nervous System; Clonidine; Decerebrate State; Dogs; Female; Heart Rate; Male; Norepinephrine; Oxazoles; Rats; Reflex; Spinal Cord; Vagotomy | 1977 |
Do centrally-acting antihypertensive drugs act at non-adrenergic as well as alpha-2 adrenoceptor sites?
Topics: Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Brain; Cisterna Magna; Clonidine; Guanabenz; Heart Rate; Infusion Pumps; Injections; Male; Osmosis; Oxazoles; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Rilmenidine | 1992 |
Influence of anaesthesia on the cardiovascular effects of rilmenidine and clonidine in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Male; Oxazoles; Pentobarbital; Rats; Rats, Inbred SHR; Reflex; Rilmenidine; Sympathetic Nervous System | 1992 |
Importance of imidazoline receptors in the cardiovascular responses to clonidine and rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Biogenic Monoamines; Brain Stem; Cardiovascular System; Clonidine; Consciousness; Imidazoline Receptors; Neurotransmitter Agents; Oxazoles; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1992 |
Does rilmenidine act in vivo on central alpha 2-adrenoceptors modulating noradrenaline release?
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Hypothalamus; Norepinephrine; Oxazoles; Rats; Receptors, Adrenergic, alpha; Rilmenidine | 1992 |
Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.
Topics: Animals; Antihypertensive Agents; Benzazepines; Binding, Competitive; Blood Pressure; Brain Stem; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Imidazoline Receptors; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1991 |
Contribution of alpha 2-adrenoceptors to the central cardiovascular effects of clonidine and S 8350 in anaesthetized rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Cardiovascular System; Cerebral Cortex; Clonidine; Heart Rate; Male; Oxazoles; Rats; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Catecholamines; Clonidine; Dioxanes; Electrochemistry; Hemodynamics; Idazoxan; Imidazoline Receptors; Male; Medulla Oblongata; Neurons; Oxazoles; Piperoxan; Rats; Rats, Inbred WKY; Receptors, Drug; Reticular Formation; Rilmenidine; Stereotaxic Techniques; Yohimbine | 1991 |
Effects of swim training alone and in combination with clonidine and rilmenidine on blood pressure, plasma electrolytes, vasopressin, and renin activity in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Weight; Clonidine; Electrolytes; Heart; Male; Organ Size; Oxazoles; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Rilmenidine; Swimming; Vasopressins | 1990 |
Importance of central noradrenergic and serotonergic pathways in the cardiovascular actions of rilmenidine and clonidine.
Topics: 5,6-Dihydroxytryptamine; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Male; Norepinephrine; Oxazoles; Oxidopamine; Rabbits; Rilmenidine; Serotonin | 1991 |
Regional hemodynamic effects of rilmenidine and clonidine in the conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Oxazoles; Rats; Rats, Inbred SHR; Renal Circulation; Rilmenidine; Splanchnic Circulation | 1991 |
Contractile reactivity of isolated resistance arteries after 4 weeks of treatment with rilmenidine, clonidine or hydralazine in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Clonidine; Hydralazine; Hypertension; In Vitro Techniques; Male; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Time Factors; Vasoconstriction | 1991 |
Desensitization and down-regulation of brain alpha 2-adrenoceptors by centrally acting antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Brain; Central Nervous System; Clonidine; Down-Regulation; Guanabenz; Hemodynamics; In Vitro Techniques; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine | 1990 |
Influence of the alpha-2 agonist oxaminozoline (S3341) on firing rate of central noradrenergic and serotonergic neurons in the rat. Comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electrophysiology; Iontophoresis; Locus Coeruleus; Male; Neurons; Norepinephrine; Oxazoles; Prazosin; Raphe Nuclei; Rats; Rilmenidine; Serotonin; Yohimbine | 1986 |
Rapid eye movement sleep and the associated cardiovascular changes during and after continuous 10-day infusion of clonidine in normotensive rats: comparison with lofexidine and S3341.
Topics: Animals; Blood Pressure; Cardiovascular System; Clonidine; Drug Administration Schedule; Female; Heart Rate; Infusions, Intravenous; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Sleep, REM; Time Factors | 1987 |
Rilmenidine differs from clonidine in that it lacks histamine-like activity.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Guinea Pigs; Heart; Heart Rate; Histamine; In Vitro Techniques; Male; Myocardium; Oxazoles; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Rilmenidine; Uterine Contraction; Uterus | 1989 |
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Guanfacine; Guanidines; Idazoxan; Kidney Tubules, Proximal; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine | 1989 |
Cardiovascular effects of rilmenidine, a new alpha 2-adrenoceptor agonist, and clonidine in conscious spontaneously hypertensive rats.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Blood Pressure; Catecholamines; Clonidine; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 1989 |
New isoxazole derivatives provided with antihypertensive activity.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Chemical Phenomena; Chemistry; Clonidine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Vas Deferens; Yohimbine | 1989 |
Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cats; Clonidine; Decerebrate State; Female; Heart Rate; Hexobarbital; In Vitro Techniques; Male; Mice; Oxazoles; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rilmenidine; Sleep; Time Factors | 1986 |
Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Central Nervous System; Chickens; Clonidine; Decerebrate State; Electric Stimulation; Heart Rate; Hemodynamics; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reflex; Rilmenidine; Sleep | 1988 |
Action of rilmenidine on locus ceruleus and dorsal raphe cells in vivo and in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Clonidine; In Vitro Techniques; Infusions, Intravenous; Iontophoresis; Locus Coeruleus; Lysergic Acid Diethylamide; Male; Oxazoles; Prazosin; Raphe Nuclei; Rats; Rats, Inbred Strains; Rilmenidine | 1988 |
Effects of two alpha 2 agonists, rilmenidine and clonidine, on the morphine withdrawal syndrome and their potential addictive properties in rats.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Male; Morphine; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Effects of continuous infusions (10 days) and cessation of infusions of clonidine and rilmenidine (S 3341) on cardiovascular and behavioral parameters of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Blood Pressure; Clonidine; Female; Heart Rate; Infusion Pumps; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Sleep, REM; Time Factors | 1988 |
Effects of rilmenidine on bronchomotor responses in the guinea pig.
Topics: Adrenergic alpha-Agonists; Animals; Bronchi; Clonidine; Compliance; Drug Synergism; Guinea Pigs; Histamine; Male; Oxazoles; Rilmenidine | 1988 |
Pharmacology of the alpha 2-adrenoceptor agonist rilmenidine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System; Chemical Phenomena; Chemistry; Clonidine; Dose-Response Relationship, Drug; Hexobarbital; Humans; Hypnotics and Sedatives; Mice; Oxazoles; Rats; Rilmenidine; Sleep | 1988 |
Prejunctional alpha 2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-delta-2-oxazoline: a comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Oxazoles; Prazosin; Rats; Rats, Inbred WKY; Rilmenidine; Vas Deferens; Yohimbine | 1987 |
Effect of the amino-oxazoline derivative S-3341 on pre- and postjunctional alpha-adrenoceptors in isolated blood vessels.
Topics: Animals; Clonidine; Dogs; In Vitro Techniques; Norepinephrine; Oxazoles; Perfusion; Phenylephrine; Prazosin; Pulmonary Artery; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Saphenous Vein; Vasoconstriction; Yohimbine | 1986 |
Interaction of clonidine and rilmenidine with imidazoline-preferring receptors.
Topics: Animals; Binding, Competitive; Clonidine; Imidazoline Receptors; In Vitro Techniques; Kidney Tubules, Proximal; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1988 |
Use of hepatocyte cultures for preliminary metabolism and cytotoxicity studies of a new anti-hypertensive agent, oxaminozoline.
Topics: Animals; Antihypertensive Agents; Biotransformation; Cells, Cultured; Clonidine; Drug Evaluation, Preclinical; Endothelium; L-Lactate Dehydrogenase; Liver; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Serum Albumin | 1988 |
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine | 1985 |
Hypothermic effect of alpha-sympathomimetic agents and their antagonism by adrenergic and cholinergic blocking drugs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aniline Compounds; Animals; Body Temperature; Cerebral Ventricles; Clonidine; Dose-Response Relationship, Drug; Hypothalamus; Injections; Injections, Intraperitoneal; Naphazoline; Oxazoles; Oxymetazoline; Parasympatholytics; Rats; Stereotaxic Techniques; Sympatholytics; Thiazines; Time Factors; Toluidines; Xylenes | 1972 |
Actions of clonidine and 2-(2-methyl-6-ethyl-cyclohexylamino)-2-oxazoline on postganglionic autonomic nerves.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Autonomic Fibers, Postganglionic; Clonidine; Cyclohexylamines; Depression, Chemical; Electric Stimulation; Guinea Pigs; Heart; Heart Rate; Hexamethonium Compounds; Ileum; Imidazoles; In Vitro Techniques; Muscle Contraction; Neurosecretion; Norepinephrine; Oxazoles; Rabbits; Synaptic Transmission | 1972 |
Antinociceptive effects of some alpha-sympathomimetic agents.
Topics: Analgesics; Aniline Compounds; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Imidazoles; Injections, Intraperitoneal; Naphazoline; Naphthalenes; Oxazoles; Oxymetazoline; Rats; Reaction Time; Reflex, Startle; Sympathomimetics; Tetrazoles; Thiazines; Toluidines; Vocalization, Animal | 1974 |
alpha 1-adrenoceptor blockade by alpha 2-adrenoceptor agonists in the isolated perfused hindquarter of rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; In Vitro Techniques; Male; Methoxamine; Oxazoles; Perfusion; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiazoles; Vasoconstriction | 1981 |
Inhibition of semicarbazide-sensitive amine oxidase by monoamine oxidase B inhibitors from the oxazolidinone series.
Topics: Animals; Clonidine; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardium; Oxazoles; Oxazolidinones; Rats; Rats, Inbred Strains; Semicarbazides | 1984 |
Binding of an imidazolidine (clonidine), an oxazoloazepin (B-HT 933) and a thiazoloazepin (B-HT 920) to rat brain alpha-adrenoceptors and relation to cardiovascular effects.
Topics: Animals; Azepines; Binding Sites; Binding, Competitive; Blood Pressure; Brain; Clonidine; Heart Rate; Kinetics; Male; Oxazoles; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiazoles | 1980 |
Central cardiovascular alpha-adrenoceptors. Relation to peripheral receptors.
Topics: Animals; Azepines; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Male; Methoxamine; Norepinephrine; Oxazoles; Perfusion; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiazoles; Vagotomy | 1980 |
Postsynaptic alpha 1- and alpha 2-adrenoceptors in the circulatory system of the pithed rat: selective stimulation of the alpha 2-type by B-HT 933.
Topics: Animals; Azepines; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Oxazoles; Phentolamine; Phenylephrine; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Vasomotor System; Yohimbine | 1980 |
Selectivity of a series of clonidine-like drugs for alpha 1 and alpha 2 adrenoceptors in rat brain.
Topics: Aniline Compounds; Animals; Cerebral Cortex; Clonidine; Guanabenz; Guanfacine; Guanidines; Imidazoles; In Vitro Techniques; Indoramin; Naphazoline; Oxazoles; Phenylacetates; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Thiophenes; Toluidines | 1980 |
Antihypertensive effect of the GABA receptor agonist muscimol in spontaneously hypertensive rats. Role of the sympathoadrenal axis.
Topics: Adrenal Glands; Animals; Atropine; Blood Pressure; Catecholamines; Clonidine; Efferent Pathways; Heart Rate; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Splanchnic Nerves; Sympathectomy, Chemical; Sympathetic Nervous System; Vagotomy | 1984 |
Antinociceptive effect of the GABAmimetic 4,5,6,7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP): chronic treatment increases alpha-2 adrenoceptors in the mouse brain.
Topics: Analgesics; Animals; Brain Chemistry; Clonidine; Drug Tolerance; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Rapid eye movement (REM)-sleep during and after continuous infusion of the oxazoline derivate S3341: a comparison with clonidine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Female; Oxazoles; Rats; Rats, Inbred WKY; Rilmenidine; Sleep, REM; Time Factors | 1984 |
Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Clonidine; Consciousness; Female; Heart Rate; Hypotension; Immunohistochemistry; Male; Oxazoles; Proto-Oncogene Proteins c-fos; Rabbits; Rats; Rilmenidine; Tyrosine 3-Monooxygenase | 1995 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Evidence for a role for imidazoline I1 binding site in rat brown adipocytes.
Topics: Adipose Tissue, Brown; Animals; Carrier Proteins; Clonidine; Imidazoline Receptors; Ion Channels; Isoproterenol; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Oxazoles; Oxygen; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine; Uncoupling Protein 1 | 1995 |
Quantitative autoradiographic localization in rat brain of alpha 2-adrenergic and non-adrenergic I-receptor binding sites labelled by [3H]rilmenidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Autoradiography; Binding Sites; Brain; Brain Chemistry; Clonidine; Epinephrine; Imidazoline Receptors; Male; Oxazoles; Radioligand Assay; Rats; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1995 |
Central alpha-2 adrenoceptors are responsible for a clonidine-induced cue in a rat drug discrimination paradigm.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Conditioning, Operant; Cues; Discrimination, Psychological; Male; Oxazoles; Rats; Receptors, Adrenergic, alpha-2; Reinforcement Schedule; Reward; Rilmenidine | 1993 |
Stimulatory effects of clonidine, cirazoline and rilmenidine on locus coeruleus noradrenergic neurones: possible involvement of imidazoline-preferring receptors.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Locus Coeruleus; Male; Membrane Potentials; Neurons; Norepinephrine; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1993 |
Down-regulation of imidazoline sites in rabbit kidney.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Down-Regulation; Guanabenz; Idazoxan; Imidazoline Receptors; Kidney; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1993 |
Differential receptors involved in the cardiovascular effects of clonidine and rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Male; Methyldopa; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1993 |
Involvement of imidazoline-preferring receptors in regulation of sympathetic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine | 1994 |
A novel mechanism of action for hypertension control: moxonidine as a selective I1-imidazoline agonist.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Autoradiography; Binding Sites; Blood Pressure; Cattle; Cells, Cultured; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1994 |
Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Felodipine; Heart Rate; Hypertension; Labetalol; Male; Metoprolol; Oxazoles; Prazosin; Propanolamines; Propranolol; Rats; Rats, Inbred SHR; Rilmenidine; Thiophenes | 1993 |
Cardiac electrophysiological effects of rilmenidine, a novel antihypertensive agent, in the conscious dog: comparison with clonidine.
Topics: Animals; Antihypertensive Agents; Atrial Function; Blood Pressure; Clonidine; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Atria; Male; Oxazoles; Rilmenidine; Sinoatrial Node | 1994 |
Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1996 |
Selectivity of rilmenidine for I1-imidazoline-binding sites in rabbit proximal tubule cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney Tubules, Proximal; Kinetics; Male; Oxazoles; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Tritium | 1995 |
Interactions of the cardiac chronotropic effects of rilmenidine with the autonomic nervous system in conscious dogs: comparison with clonidine.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Chronic Disease; Clonidine; Depression, Chemical; Dogs; Female; Heart Block; Heart Rate; Male; Muscarinic Antagonists; Oxazoles; Phenoxybenzamine; Pindolol; Rilmenidine; Yohimbine | 1996 |
No evidence for functional imidazoline receptors on locus coeruleus neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Locus Coeruleus; Male; Microelectrodes; Neurons; Oxazoles; Quinolines; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Antinociceptive effects of oral clonidine and S12813-4 in acute colon inflammation in rats.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Colitis; Female; Formaldehyde; Idazoxan; Oxazoles; Rats; Rats, Sprague-Dawley; Yohimbine | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
Cardiac vagal effects of rilmenidine in the dog: comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Female; Heart; Heart Rate; In Vitro Techniques; Male; Oxazoles; Rilmenidine; Vagus Nerve | 1997 |
Alpha 2-adrenergic mechanisms of analgesia: strategies for improving their therapeutic window and identification of the novel, potent alpha 2A-adrenergic receptor agonist, S 18616.
Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Brain Stem; Clonidine; Humans; Mice; Oxazoles; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Spinal Cord; Transfection | 1998 |
Ethanol selectively counteracts hypotension evoked by central I(1)-imidazoline but not alpha2-adrenergic receptor activation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Clonidine; Ethanol; Heart Rate; Hypertension; Imidazoline Receptors; Male; Nordefrin; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1998 |
Rilmenidine reveals differences in the pharmacological characteristics of prejunctional alpha2-adrenoceptors in the guinea-pig, rat and pig.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle Contraction; Oxazoles; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Rilmenidine; Species Specificity; Swine; Vas Deferens | 1998 |
Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 1998 |
Comparison of the baroreceptor-heart rate reflex effects of moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Algorithms; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Clonidine; Female; Heart Rate; Imidazoles; Injections, Intraventricular; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Vagus Nerve | 1998 |
Influence of sino-aortic barodenervation on the cardiovascular effects of imidazoline-like drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Clonidine; Denervation; Heart Rate; Imidazoles; Injections, Intravenous; Male; Motor Activity; Oxazoles; Pressoreceptors; Rats; Rats, Wistar; Rilmenidine; Sinus of Valsalva; Telemetry | 1998 |
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice.
Topics: Adrenergic alpha-Antagonists; Amino Acid Substitution; Animals; Binding, Competitive; Blood Pressure; Cardiovascular Agents; Cell Line; Clonidine; Consciousness; Dogs; Heart Rate; Humans; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Mutation; Naphthyridines; Oxazoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Rilmenidine; Saphenous Vein; Tritium | 1999 |
Inhibition of water permeability in the rat collecting duct: effect of imidazoline and alpha-2 compounds.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arginine Vasopressin; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Imidazoles; Kidney Tubules, Collecting; Medetomidine; Oxazoles; Oxymetazoline; Permeability; Rats; Rats, Wistar; Rilmenidine; Water | 1999 |
Identification of imidazoline-receptor binding sites in cortex and medulla of the bovine adrenal gland. Colocalization with MAO-A and MAO-B.
Topics: Adrenal Cortex; Adrenal Medulla; Adrenergic beta-Agonists; Animals; Autoradiography; Benzofurans; Binding Sites; Cattle; Clonidine; Imidazoles; Imidazoline Receptors; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rats; Receptors, Drug; Rilmenidine; Thiazoles; Tritium | 1999 |
Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Clonidine; Decerebrate State; Heart Rate; Imidazoles; Injections, Spinal; Medulla Oblongata; Microinjections; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Central imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Microinjections; Models, Neurological; Norepinephrine; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Serotonin; Sympathetic Nervous System | 1999 |
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Clonidine; Denervation; Heart Rate; Hypotension; Imidazoles; Male; Oxazoles; Pressoreceptors; Rats; Rats, Inbred SHR; Rilmenidine; Sinus of Valsalva; Time Factors | 1999 |
Cardiovascular effects of clonidine-like drugs in pithed rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular Physiological Phenomena; Clonidine; Electric Stimulation; Heart Rate; Imidazoles; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Synaptic Transmission | 1999 |
[New central agents in the treatment of arterial hypertension].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Clonidine; Diabetes Complications; Humans; Hypertension; Imidazoles; Nifedipine; Oxazoles; Renin-Angiotensin System; Reserpine; Rilmenidine; Risk Factors; Sympathetic Nervous System; Vasodilator Agents | 1999 |
Three-dimensional quantitative structure-activity studies of octopaminergic agonists responsible for the inhibition of sex-pheromone production in Helicoverpa [correction of Hercoverpa] armigera.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Female; Imidazoles; Lepidoptera; Male; Models, Molecular; Moths; Octopamine; Oxazoles; Pheromones; Structure-Activity Relationship | 1999 |
Actions of L-NAME and methylene blue on the hypotensive effects of clonidine and rilmenidine in the anesthetized rat.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxazoles; Rats; Rats, Wistar; Rilmenidine | 2000 |
S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Body Temperature; CHO Cells; Clonidine; Cricetinae; Dexmedetomidine; Humans; Imidazoles; Imidazoline Receptors; Male; Mice; Oxazoles; Rats; Rats, Wistar; Receptors, Drug | 2000 |
S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Biogenic Monoamines; Clonidine; Dexmedetomidine; Imidazoles; Locus Coeruleus; Male; Mice; Motor Activity; Oxazoles; Raphe Nuclei; Rats; Rats, Wistar; Ventral Tegmental Area; Vocalization, Animal | 2000 |
Nitric oxide and central antihypertensive drugs: one more difference between catecholamines and imidazolines.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Catecholamines; Clonidine; Heart Rate; Hypotension; Imidazoles; Male; Nitric Oxide; Nitroarginine; Nordefrin; Oxazoles; Rabbits; Rilmenidine | 2001 |
Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Heart Rate; Imidazoles; Male; Microdialysis; Norepinephrine; Oxazoles; Prefrontal Cortex; Rats; Rats, Wistar; Rilmenidine; Sympathetic Nervous System | 2001 |
Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Electrocardiography; Female; Glutamic Acid; Heart Rate; Hemodynamics; Male; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Oxazoles; Propranolol; Rabbits; Rilmenidine; Sympathetic Nervous System | 2003 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Azepines; Brimonidine Tartrate; Clonidine; Idazoxan; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxazoles; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Yohimbine | 2002 |
Effect of ethanol on reductions in norepinephrine electrochemical signal in the rostral ventrolateral medulla and hypotension elicited by I1-receptor activation in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Ethanol; Hypotension; Imidazoline Receptors; Male; Medulla Oblongata; Microdialysis; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Sympatholytics | 2003 |
The effects of the alpha2-adrenergic receptor agonists clonidine and rilmenidine, and antagonists yohimbine and efaroxan, on the spinal cholinergic receptor system in the rat.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzofurans; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Injections, Spinal; Ligands; Male; Microdialysis; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Cholinergic; Rilmenidine; Spinal Cord; Time Factors; Yohimbine | 2004 |
Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Clonidine; Cyclopropanes; Imidazoline Receptors; Microcirculation; Oxazoles; Pyrroles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Splanchnic Circulation; Sympathetic Nervous System; Vasodilation | 2004 |
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Brain Stem; Cerebrospinal Fluid; Clonidine; Consciousness; Gene Expression; Heart Rate; Hydralazine; Hypotension; Imidazoles; Imidazoline Receptors; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Nordefrin; Oxazoles; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; RNA, Messenger; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Postrema; Benzazepines; Benzofurans; Blood Pressure; Clonidine; Consciousness; Heart Rate; Hypotension; Imidazoles; Interleukin-1; Male; Motor Activity; Neurons; Nordefrin; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Rilmenidine; Solitary Nucleus | 2005 |
Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Avoidance Learning; Behavior, Animal; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Imidazoline Receptors; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2005 |
Central actions of agmatine in conscious spontaneously hypertensive rats.
Topics: Agmatine; Animals; Antihypertensive Agents; Blood Pressure; Brain; Cardiovascular System; Clonidine; Consciousness; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hypertension; Injections, Intraventricular; Male; Movement; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 2005 |
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Cholesterol; Clonidine; Disease Models, Animal; Female; Guanabenz; Hyperlipidemias; Imidazoles; Imidazoline Receptors; Liver; Male; Metabolic Syndrome; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Triglycerides | 2006 |
Direct evidence for imidazoline (I1) receptor modulation of ethanol action on norepinephrine-containing neurons in the rostral ventrolateral medulla in conscious spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System Depressants; Clonidine; Dose-Response Relationship, Drug; Electrochemistry; Ethanol; Heart Rate; Imidazoline Receptors; Male; Medulla Oblongata; Microinjections; Neurons; Nordefrin; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 2007 |
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer | 2008 |
Alpha 2A-adrenergic receptor signaling underlies synergistic enhancement of ethanol-induced behavioral impairment by clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Behavior, Animal; Central Nervous System Depressants; Cerebellum; Clonidine; Drug Synergism; Ethanol; Imidazoline Receptors; Locus Coeruleus; Male; Motor Activity; Oxazoles; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Rilmenidine; Rotarod Performance Test | 2009 |
Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Clonidine; Disease Models, Animal; Edema; Gastrointestinal Motility; Hyperalgesia; Male; Oxazoles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Stomach Ulcer | 2009 |
Microvascular effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Clonidine; Disease Models, Animal; Hypertension; Imidazoles; Male; Microcirculation; Microscopy, Video; Muscle, Skeletal; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rilmenidine; Skin; Time Factors | 2010 |
Investigation of the effects of the chronic administration of some antihypertensive drugs on enzymatic and non-enzymatic oxidant/antioxidant parameters in rat ovarian tissue.
Topics: Amlodipine; Animals; Antihypertensive Agents; Antioxidants; Clonidine; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Methyldopa; Ovary; Oxazoles; Oxidants; Ramipril; Rats; Rats, Wistar; Rilmenidine; Superoxide Dismutase | 2011 |
Advantageous safety profile of a dual selective alpha(2C) agonist/alpha(2A) antagonist antinociceptive agent.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Clonidine; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Male; Mice; Oxazoles; Pain; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 2014 |
Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diet, High-Fat; Intravital Microscopy; Male; Metabolic Syndrome; Microcirculation; Microvessels; Muscle, Skeletal; Oxazoles; Rats; Rats, Wistar; Rilmenidine; Sodium Chloride, Dietary; Sympathetic Nervous System; Sympatholytics | 2016 |
Activation of alpha-1 adrenergic receptors increases cytosolic calcium in neurones of the paraventricular nucleus of the hypothalamus.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Benzophenanthridines; Cadmium Chloride; Calcium; Clonidine; Cytosol; Estrenes; Macrocyclic Compounds; Male; Neurons; Norepinephrine; Oxazoles; Paraventricular Hypothalamic Nucleus; Phenylephrine; Prazosin; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha-1; Thapsigargin | 2019 |