clonidine and nicotine

clonidine has been researched along with nicotine in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (25.25)	18.7374
1990's	26 (26.26)	18.2507
2000's	36 (36.36)	29.6817
2010's	12 (12.12)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Giacomini, KM; Schaner, ME; Zhang, L	1
Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X	1
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Lisciani, R; Silvestrini, B	1
Gala, RR; Lawson, DM	1
Cavalheiro, EA; Izquierdo, I	1
Sybertz, EJ; Zimmerman, BG	1
Daughton, DM; Grimm, RH; Heim, C; Nett, L; Petty, TL; Prochazka, AV; Rennard, SI; Sachs, DP; Silvers, GW	1
Brasch, H	1
Leischow, SJ; Sachs, DP	1
Fagerström, KO	1
Covey, LS; Glassman, AH	1
Dunnett, SB; Martel, FL	1
Bozarth, MA; Murray, A; Wise, RA	1
Fellhauer, M	1
McGee, KH; Murray, KM	1
Prignot, J	1
Cordes, DH; Green, JJ	1
Poser, W	1
Kitazawa, T; Kondo, H; Temma, K	1
Malhotra, RK; Sharma, TR; Wakade, AR; Wakade, TD	1
De Léan, A; Nguyen, TT	1
Ghazi, H; Osborne, NN	1
Muramatsu, I; Oshita, M; Yamanaka, K	1
Kigoshi, S; Muramatsu, I; Yamanaka, K	1
Hammond, JR; MacDonald, WF; White, TD	1
Livett, BG; Marley, PD; Powis, DA; Wan, DC	1
Hughes, JR	1
Coates, TJ; Cummings, SR; Hansen, B; Richard, RJ; Stein, MJ	1
Gurin, VN; Tsariuk, VV; Vismont, FI	1
Abou Zeit-Har, MS; Arnerić, SP; Cannon, JG; Lecompte, J; Lee, T; Long, JP; Maixner, W; Verimer, T	1
Borciani, E; Camellini, L; Chiodera, P; Coiro, V; d'Amato, L; Maffei, ML; Pignatti, D; Rossi, G	1
Peters, DA	1
Everitt, BJ; Lightman, SL; Todd, K	1
Nishimura, S; Sorimachi, M; Yamagami, K	1
Ernsberger, P; Evinger, MJ; Regunathan, S; Reis, DJ	1
Altman, HJ; Commissaris, RL; Pitts, DK; Verbanac, JS	1
Bassoul, B; Bruelle, P; de La Coussaye, JE; Desch, G; Eledjam, JJ; Lefrant, JY; Peray, PA; Saïssi, G; Sassine, A	1
Alegría, E; Aparici, M; Fernández González, AL	1
Appalsamy, M; Mosqueda-Garcia, R; Robertson, D; Tseng, CJ	1
Bickel, WK; Higgins, ST; Hughes, JR	1
Cooper, TB; Covey, LS; Dalack, GW; Fleiss, J; Glassman, AH; Rivelli, SK; Stetner, F	1
Cocores, JA; Miller, NS	1
D'Alonzo, GE; Lee, EW	1
Okamura, T; Toda, N; Uchiyama, M	1
Cavalletti, M; Corsini, GU; Fascetti, F; Fornai, F; Tedeschi, D; Vaglini, F	1
Burden, HW; Davis, MC; Hodson, CA	1
Lous, J	1
Bartolini, A; Bellucci, C; Dei, S; Galeotti, N; Ghelardini, C; Gualtieri, F; Manetti, D; Romanelli, MN; Scapecchi, S; Teodori, E	1
Babaie, A; Etminani, A; Gharib, B; Homayoun, H; Zarrindast, MR	1
Clemente Jiménez, M; Pérez Trullén, A	1
Hatsukami, DK; Kotlyar, M	1
Alva, H; Blednov, YA; Harris, RA; Stoffel, M	1
Aldrich, TK; Appel, DW	1
Ahmadi, J; Ahmadi, M; Ahmadi, N; Ashkani, H	1
Roddy, E	1
Villanueva, EV; Zavarsek, S	1
Jain, M; Talwar, A; Vijayan, VK	1
Schroeder, SA	1
Foulds, J; Steinberg, MB; Williams, JM; Ziedonis, DM	1
Corelli, RL; Hudmon, KS	1
Cofta-Woerpel, L; Wetter, DW; Wright, KL	2
Dicpinigaitis, PV; Sakalauskas, R; Sitkauskiene, B; Stravinskaite, K	1
Hill, A	1
Kanarek, RB; Mathes, WF	1
Frishman, WH	1
Bruijnzeel, AW; Desai, TV; Prado, M; Shah, HP; Zislis, G	1
Buchhalter, AR; Fant, RV; Henningfield, JE	1
Bau, CH; Bizarro, L; Dobler, CJ; Kortmann, GL	1
Deissenrieder, F; Groneberg, D; Kusma, B; Mache, S; Quarcoo, D; Welte, T	1
Engelmann, JM; Gewirtz, JC; Radke, AK	1
Chopde, CT; Gahane, AY; Kotagale, NR; Taksande, BG; Ugale, RR	1
Bhat, A; Crain, D	1
Bruckmann, W; De Vry, J; Rutten, K; Tzschentke, TM; Van Der Kam, EL	1
Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Keijzers, KF; Pasek, TM; van Tuijl, IA; Yamada, H; Yavarovich, KR	1
Iezhitsa, IN; Kharitonova, MV; Kravchenko, MS; Spasov, AA	1
Belcon, AL	1
Alexander, JC; Bishnoi, M; Bruijnzeel, AW; Ford, J; Ji, Y; Rogers, JA; Scheick, S	1
Ebbert, JO; Elrashidi, MY	1
Bashiri, H; Rezayof, A; Sahebgharani, M; Tavangar, SM; Zarrindast, MR	1

Reviews

22 review(s) available for clonidine and nicotine

Article	Year
Pharmacologic approaches to smoking cessation. Clinics in chest medicine, 1991, Volume: 12, Issue:4 Topics: Clonidine; Doxepin; Humans; Nicotine; Smoking; Smoking Cessation; Weight Gain	1991
Towards better diagnoses and more individual treatment of tobacco dependence. British journal of addiction, 1991, Volume: 86, Issue:5 Topics: Antidepressive Agents; Behavior Therapy; Clonidine; Combined Modality Therapy; Humans; Nicotine; Personality Tests; Smoking; Substance Withdrawal Syndrome	1991
Future trends in the pharmacological treatment of smoking cessation. Drugs, 1990, Volume: 40, Issue:1 Topics: Anti-Anxiety Agents; Antidepressive Agents; Chewing Gum; Clonidine; Humans; Nicotine; Smoking	1990
Pharmacological approach to smoking cessation. The European respiratory journal, 1989, Volume: 2, Issue:6 Topics: Clonidine; Humans; Nicotine; Smoking	1989
Common errors in the pharmacologic treatment of drug dependence and withdrawal. Comprehensive therapy, 1994, Volume: 20, Issue:2 Topics: Behavior Therapy; Buprenorphine; Clonidine; Humans; Lithium; Methadone; Narcotics; Nicotine; Psychotherapy; Substance Withdrawal Syndrome; Thiamine	1994
Nicotine dependence: diagnosis, chemistry, and pharmacologic treatments. Pediatrics in review, 1993, Volume: 14, Issue:7 Topics: Acetates; Acetic Acid; Administration, Cutaneous; Adolescent; Chewing Gum; Clonidine; Female; Humans; Male; Nicotine; Plants, Toxic; Polymethacrylic Acids; Polyvinyls; Prevalence; Risk Factors; Scopolamine; Smoking; Smoking Cessation; Substance-Related Disorders; Tobacco Use Cessation Devices; Tobacco, Smokeless	1993
Cigarette smoking, nicotine addiction, and its pharmacologic treatment. Archives of internal medicine, 1993, Jan-11, Volume: 153, Issue:1 Topics: Chewing Gum; Clonidine; Costs and Cost Analysis; Humans; Nicotine; Polymethacrylic Acids; Polyvinyls; Smoking; Substance-Related Disorders; Tobacco Use Cessation Devices	1993
[Support and guidelines, nicotine substitutes and clonidine have positive effects on smoking cessation. Five Cochrane meta-analyses on agents used in smoking cessation]. Ugeskrift for laeger, 1997, Sep-22, Volume: 159, Issue:39 Topics: Adrenergic alpha-Agonists; Clonidine; Counseling; Denmark; Humans; Meta-Analysis as Topic; Nicotine; Randomized Controlled Trials as Topic; Smoking Cessation; Social Support	1997
[Current and future drug therapies for smoking cessation]. Archivos de bronconeumologia, 2001, Volume: 37, Issue:4 Topics: Administration, Cutaneous; Administration, Oral; Anti-Anxiety Agents; Antidepressive Agents; Central Nervous System Stimulants; Chewing Gum; Clinical Protocols; Clonidine; Delayed-Action Preparations; Humans; Lobeline; Mecamylamine; Nebulizers and Vaporizers; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polymethacrylic Acids; Polyvinyls; Smoking; Tobacco Use Cessation Devices	2001
Managing nicotine addiction. Journal of dental education, 2002, Volume: 66, Issue:9 Topics: Administration, Inhalation; Adolescent; Adult; Antidepressive Agents, Tricyclic; Bupropion; Chewing Gum; Clonidine; Drug Combinations; Female; Humans; Logistic Models; Nicotine; Nicotinic Agonists; Nortriptyline; Pregnancy; Smoking; Sympatholytics; Tobacco Use Cessation; Tobacco Use Disorder; United States; United States Agency for Healthcare Research and Quality; Women's Health	2002
Smoking cessation in the elderly. Clinics in geriatric medicine, 2003, Volume: 19, Issue:1 Topics: Administration, Cutaneous; Aged; Behavior Therapy; Clonidine; Counseling; Habits; Humans; Nicotine; Pulmonary Disease, Chronic Obstructive; Risk Assessment; Risk Factors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome	2003
Bupropion and other non-nicotine pharmacotherapies. BMJ (Clinical research ed.), 2004, Feb-28, Volume: 328, Issue:7438 Topics: Administration, Inhalation; Adrenergic alpha-Agonists; Antidepressive Agents, Second-Generation; Bupropion; Clonidine; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; Smoking Cessation	2004
Pharmacotherapy of tobacco dependence. The Medical clinics of North America, 2004, Volume: 88, Issue:6 Topics: Adrenergic alpha-Agonists; Adult; Antidepressive Agents, Second-Generation; Bupropion; Clonidine; Female; Humans; Male; Nicotine; Nicotinic Agonists; Smoking; Smoking Cessation; Tobacco Use Disorder; United States	2004
Developments in pharmacotherapy for tobacco dependence: past, present and future. Drug and alcohol review, 2006, Volume: 25, Issue:1 Topics: Adolescent; Adult; Bupropion; Clinical Trials as Topic; Clonidine; Drug Administration Routes; Female; Humans; Male; Nicotine; Nicotinic Agonists; Nortriptyline; Pregnancy; Smoking Cessation; Smoking Prevention; Treatment Outcome	2006
Pharmacologic interventions for smoking cessation. Critical care nursing clinics of North America, 2006, Volume: 18, Issue:1 Topics: Administration, Cutaneous; Administration, Inhalation; Antidepressive Agents, Second-Generation; Benzazepines; Bupropion; Chewing Gum; Clonidine; Critical Care; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Nurse's Role; Patient Education as Topic; Patient Selection; Phytotherapy; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking Cessation; Smoking Prevention; United States; United States Food and Drug Administration; Varenicline	2006
Smoking cessation 1: pharmacological treatments. Behavioral medicine (Washington, D.C.), 2006,Summer, Volume: 32, Issue:2 Topics: Bupropion; Clonidine; Female; Humans; Male; Nicotine; Smoking Cessation	2006
A cost-effectiveness evaluation of single and combined smoking cessation interventions in Texas. Texas medicine, 2006, Volume: 102, Issue:8 Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Bupropion; Clonidine; Cost-Benefit Analysis; Decision Trees; Drug Therapy, Combination; Health Care Costs; Humans; Nicotine; Nortriptyline; Smoking; Smoking Cessation; Texas; Tobacco Use Disorder; Treatment Outcome	2006
Smoking cessation 3: multicomponent interventions. Behavioral medicine (Washington, D.C.), 2007,Winter, Volume: 32, Issue:4 Topics: Behavior Therapy; Bupropion; Clonidine; Combined Modality Therapy; Humans; Motivation; Nicotine; Nortriptyline; Psychotherapy, Brief; Smoking Cessation; Tobacco Use Disorder	2007
Smoking cessation pharmacotherapy--nicotine and non-nicotine preparations. Preventive cardiology, 2007,Spring, Volume: 10, Issue:2 Suppl 1 Topics: Administration, Cutaneous; Administration, Inhalation; Benzazepines; Bupropion; Chewing Gum; Clonidine; Coronary Artery Disease; Humans; Monoamine Oxidase Inhibitors; Nicotine; Nortriptyline; Piperidines; Pyrazoles; Quinoxalines; Receptors, Nicotinic; Rimonabant; Selective Serotonin Reuptake Inhibitors; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tobacco, Smokeless; Varenicline	2007
Novel pharmacological approaches for treating tobacco dependence and withdrawal: current status. Drugs, 2008, Volume: 68, Issue:8 Topics: Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Clonidine; Cytochrome P-450 CYP2A6; Drug Delivery Systems; GABA Modulators; Humans; Narcotic Antagonists; Nicotine; Piperidines; Pyrazoles; Receptors, Nicotinic; Rimonabant; Substance Withdrawal Syndrome; Tobacco Use Disorder; Vaccination	2008
Pharmacogenetics of smoking cessation therapy. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010, Jan-05, Volume: 153B, Issue:1 Topics: Benzazepines; Bupropion; Clonidine; Genome-Wide Association Study; Humans; Nicotine; Nortriptyline; Pharmacogenetics; Quinoxalines; Smoking Cessation; Varenicline	2010
Emerging drugs for the treatment of tobacco dependence: 2014 update. Expert opinion on emerging drugs, 2014, Volume: 19, Issue:2 Topics: Atomoxetine Hydrochloride; Benzazepines; Bupropion; Clinical Trials as Topic; Clonidine; Humans; Mecamylamine; Nicotine; Nortriptyline; Propylamines; Quinoxalines; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline	2014

Trials

5 trial(s) available for clonidine and nicotine

Article	Year
Transdermal clonidine reduced some withdrawal symptoms but did not increase smoking cessation. Archives of internal medicine, 1992, Volume: 152, Issue:10 Topics: Administration, Cutaneous; Adult; Anxiety; Behavior Therapy; Clonidine; Double-Blind Method; Female; Humans; Irritable Mood; Male; Nicotine; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors	1992
[Clonidine in the treatment of tobacco withdrawal. A comparison with nicotine chewing gum]. Revista clinica espanola, 1994, Volume: 194, Issue:6 Topics: Adult; Chewing Gum; Clonidine; Female; Humans; Male; Nicotine; Prospective Studies; Smoking Cessation; Spain; Substance Withdrawal Syndrome; Tobacco Use Disorder	1994
Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers. Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:6 Topics: Adolescent; Adult; Aged; Clonidine; Depression; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nicotine; Placebos; Risk Factors; Sex Factors; Smoking; Smoking Cessation; Substance-Related Disorders	1993
Twenty-four week maintenance treatment of cigarette smoking with nicotine gum, clonidine and naltrexone. Journal of substance abuse treatment, 2003, Volume: 24, Issue:3 Topics: Adult; Antihypertensive Agents; Chewing Gum; Clonidine; Double-Blind Method; Humans; Iran; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Nicotine; Prospective Studies; Smoking; Smoking Cessation; Smoking Prevention; Time Factors	2003
Changes in cough reflex sensitivity after cessation and resumption of cigarette smoking. Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:3 Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Non-Narcotic; Breath Tests; Capsaicin; Carbon Monoxide; Clonidine; Cough; Female; Humans; Male; Middle Aged; Nicotine; Recurrence; Reflex; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Time Factors	2007

Other Studies

72 other study(ies) available for clonidine and nicotine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection	1998
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2 Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis	1999
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium	1999
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Molecular pharmacology, 2003, Volume: 63, Issue:3 Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms. Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:5 Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice, Inbred Strains; Nicotine; Oxotremorine; Parkinson Disease, Secondary; Phenoxybenzamine; Piloerection; Pyrilamine; Rabbits; Salivation; Sympathetic Nervous System; Trazodone; Tremor	1976
The influence of adrenergic, dopaminergic, cholinergic and serotoninergic drugs on plasma prolactin levels in ovariectomized, estrogen-treated rats. Endocrinology, 1975, Volume: 96, Issue:2 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Apomorphine; Arecoline; Atropine; Castration; Clonidine; Dibenzothiepins; Dopamine; Estradiol; Female; Isoproterenol; Mecamylamine; Nicotine; Parasympathomimetics; Phenoxybenzamine; Phentolamine; Pimozide; Piperazines; Prolactin; Rats; Serotonin; Serotonin Antagonists; Stimulation, Chemical; Sulfides	1975
Three main factors in rat shuttle behavior: their pharmacology and sequential entry in operation during a two-way avoidance session. Psychopharmacology, 1976, Sep-17, Volume: 49, Issue:2 Topics: Animals; Apomorphine; Atropine; Atropine Derivatives; Avoidance Learning; Clonidine; Conditioning, Classical; Conditioning, Operant; Drive; Female; Haloperidol; Male; Nicotine; Phenoxybenzamine; Physostigmine; Rats	1976
Facilitation of Chemoreceptor-induced reflex vasoconstriction by intravertebral arterial administration of clonidine. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:1 Topics: Animals; Carotid Arteries; Chemoreceptor Cells; Clonidine; Cyanides; Dogs; Infusions, Intra-Arterial; Nicotine; Vagotomy; Vasoconstriction; Vertebral Artery	1977
No influence of prejunctional alpha 2-adrenoceptors on the effects of nicotine and tyramine in guinea-pig atria. Journal of autonomic pharmacology, 1991, Volume: 11, Issue:1 Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Guinea Pigs; Heart; Idazoxan; In Vitro Techniques; Male; Myocardial Contraction; Nicotine; Receptors, Adrenergic, alpha; Tetrodotoxin; Tyramine	1991
Proactive interference effects on short-term memory in rats: I. Basic parameters and drug effects. Behavioral neuroscience, 1990, Volume: 104, Issue:5 Topics: Aging; Animals; Appetitive Behavior; Association Learning; Clonidine; Discrimination Learning; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Memory, Short-Term; Nicotine; Orientation; Physostigmine; Proactive Inhibition; Problem Solving; Rats; Rats, Inbred Strains; Reinforcement Schedule; Retention, Psychology; Time Perception	1990
Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats. Psychopharmacology, 1990, Volume: 100, Issue:3 Topics: Animals; Bromocriptine; Clonidine; Cocaine; Conditioning, Operant; Ethanol; Heroin; Male; Nicotine; Rats; Reinforcement Schedule; Reinforcement, Psychology; Self Administration	1990
[Drug treatment of nicotine dependence]. Medizinische Monatsschrift fur Pharmazeuten, 1990, Volume: 13, Issue:6 Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndrome	1990
Clonidine in nicotine withdrawal. DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:6 Topics: Administration, Oral; Clonidine; Humans; Nicotine; Substance Withdrawal Syndrome; Tobacco Use Disorder	1989
Transdermal clonidine therapy and nicotine withdrawal. The Western journal of medicine, 1989, Volume: 151, Issue:1 Topics: Administration, Cutaneous; Adult; Aged; Clonidine; Female; Humans; Nicotine; Substance-Related Disorders	1989
[Dependence on nicotine in chewing gum]. Deutsche medizinische Wochenschrift (1946), 1989, Oct-20, Volume: 114, Issue:42 Topics: Adult; Chewing Gum; Clonidine; Humans; Male; Nicotine; Smoking Prevention; Substance-Related Disorders	1989
Presynaptic alpha-adrenoceptor mediated inhibition of the neurogenic cholinergic contraction in the isolated intestinal bulb of the carp (Cyprinus carpio). Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 83, Issue:2 Topics: Animals; Atropine; Carps; Catecholamines; Clonidine; Cyprinidae; Electric Stimulation; Epinephrine; Female; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Parasympathetic Nervous System; Phentolamine; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha; Tetrodotoxin; Yohimbine	1986
Secretion of catecholamines from the perfused adrenal gland of the rat is not regulated by alpha-adrenoceptors. European journal of pharmacology, 1986, Mar-18, Volume: 122, Issue:2 Topics: Adrenal Glands; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Catecholamines; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Nicotine; Perfusion; Phentolamine; Phenylephrine; Rats; Receptors, Adrenergic, alpha; Yohimbine	1986
Nonadrenergic modulation by clonidine of the cosecretion of catecholamines and enkephalins in adrenal chromaffin cells. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:5 Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Animals; Catecholamines; Cattle; Cells, Cultured; Clonidine; Enkephalin, Leucine; Epinephrine; Nicotine; Norepinephrine; Receptors, Adrenergic, alpha; Reserpine	1987
Agonist-induced stimulation of inositol phosphates in primary rabbit retinal cultures. Journal of neurochemistry, 1988, Volume: 50, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carbachol; Cells, Cultured; Clonidine; Dopamine; gamma-Aminobutyric Acid; Inositol Phosphates; Isoproterenol; Neurotransmitter Agents; Nicotine; Norepinephrine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Serotonin; Retina; Serotonin; Sugar Phosphates; Tetrahydronaphthalenes	1988
Alteration of alpha and muscarinic receptors in rat brain and heart following chronic nicotine treatment. Brain research, 1985, Dec-02, Volume: 348, Issue:2 Topics: Animals; Brain; Brain Stem; Cerebral Cortex; Clonidine; Hypothalamus; Male; Myocardium; Nicotine; Prazosin; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Thalamus; Time Factors	1985
Effect of chronic nicotine treatment against repeated immobilization stress. Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:2 Topics: Animals; Cerebral Cortex; Clonidine; Dihydroalprenolol; Hippocampus; Kinetics; Male; Nicotine; Organ Specificity; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Muscarinic; Restraint, Physical; Stress, Psychological	1987
Evoked secretion of [3H]noradrenaline and ATP from nerve varicosities isolated from the myenteric plexus of the guinea pig ileum. Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:4 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Myenteric Plexus; Nicotine; Norepinephrine; Potassium; Veratridine; Yohimbine	1988
Effects of alpha- and beta-adrenoceptor agonists and antagonists on ATP and catecholamine release and desensitization of the nicotinic response in bovine adrenal chromaffin cells. Biochemical pharmacology, 1988, Feb-15, Volume: 37, Issue:4 Topics: Adenosine Triphosphate; Animals; Barium; Calcium; Catecholamines; Cattle; Cell Membrane; Chromaffin System; Clonidine; Histamine; In Vitro Techniques; Nicotine; Potassium; Propranolol; Receptors, Adrenergic; Sodium	1988
Clonidine, depression, and smoking cessation. JAMA, 1988, May-20, Volume: 259, Issue:19 Topics: Behavior Therapy; Clonidine; Depression; Humans; Nicotine; Smoking	1988
Heavy smokers, smoking cessation, and clonidine. JAMA, 1988, Sep-16, Volume: 260, Issue:11 Topics: Administration, Cutaneous; Clonidine; Humans; Nicotine; Smoking	1988
Internists and nicotine gum. JAMA, 1988, Sep-16, Volume: 260, Issue:11 Topics: Attitude of Health Personnel; California; Chewing Gum; Clonidine; Drug Administration Schedule; Drug Utilization; Humans; Inservice Training; Internal Medicine; Nicotine; Smoking Prevention	1988
[Effect of synaptically active substances on the hyperthermic effect of prostaglandin E2 in rats]. Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 91, Issue:3 Topics: Animals; Benactyzine; Body Temperature; Clonidine; Diphenylacetic Acids; Hemicholinium 3; Isoproterenol; Methysergide; Nicotine; Norepinephrine; Oxotremorine; Phenoxybenzamine; Propranolol; Prostaglandins E; Rats; Serotonin	1981
Pharmacological effects of 2-aminotetralins, octahydrobenzo[f]quinolines and clonidine on the isolated guinea pig ileum. European journal of pharmacology, 1981, May-22, Volume: 71, Issue:4 Topics: 2-Naphthylamine; Acetylcholine; Animals; Clonidine; Electric Stimulation; Guinea Pigs; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naphthalenes; Nicotine; Parasympatholytics; Potassium; Quinolines; Structure-Activity Relationship; Tetrahydronaphthalenes	1981
Nicotine from cigarette smoking enhances clonidine-induced increase of serum growth hormone concentrations in men. British journal of clinical pharmacology, 1984, Volume: 18, Issue:5 Topics: Adult; Clonidine; Growth Hormone; Humans; Male; Nicotiana; Nicotine; Plants, Toxic; Smoke; Smoking; Stimulation, Chemical	1984
Prenatal nicotine exposure increases adrenergic receptor binding in the rat cerebral cortex. Research communications in chemical pathology and pharmacology, 1984, Volume: 46, Issue:3 Topics: Animals; Body Weight; Cerebral Cortex; Clonidine; Dihydroalprenolol; Dioxanes; Female; Neurons; Nicotine; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Time Factors	1984
Ascending noradrenergic projections from the brainstem: evidence for a major role in the regulation of blood pressure and vasopressin secretion. Experimental brain research, 1984, Volume: 55, Issue:1 Topics: Afferent Pathways; Animals; Arginine Vasopressin; Blood Pressure; Blood Volume; Brain Stem; Clonidine; Locus Coeruleus; Male; Medulla Oblongata; Nicotine; Norepinephrine; Paraventricular Hypothalamic Nucleus; Pressoreceptors; Rats; Rats, Inbred Strains; Supraoptic Nucleus	1984
Inability of Ca2+ influx through nicotinic ACh receptor channels to stimulate catecholamine secretion in bovine adrenal chromaffin cells: studies with fura-2 and SBFI microfluorometry. The Japanese journal of physiology, 1994, Volume: 44, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Animals; Calcium; Calcium Channels; Catecholamines; Cations, Divalent; Cattle; Clonidine; Cytophotometry; Dose-Response Relationship, Drug; Electrophysiology; Fura-2; Gallopamil; Guanethidine; Hexamethonium; Manganese; Nicotine; Nifedipine; Oxotremorine; Receptors, Nicotinic; Sodium; Spectrometry, Fluorescence	1994
Regulation of phenylethanolamine N-methyltransferase gene expression by imidazoline receptors in adrenal chromaffin cells. Journal of neurochemistry, 1995, Volume: 65, Issue:3 Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; Chromaffin System; Clonidine; Gene Expression Regulation; Imidazoline Receptors; Male; Nicotine; Phenylethanolamine N-Methyltransferase; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Tyrosine 3-Monooxygenase	1995
Electrophysiological characteristics of locus coeruleus neurons in the Maudsley reactive (MR) and non-reactive (MNRA) rat strains. Neuroscience letters, 1994, Sep-26, Volume: 179, Issue:1-2 Topics: Action Potentials; Animals; Anxiety; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Locus Coeruleus; Neural Conduction; Neurons; Nicotine; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Species Specificity	1994
Receptor mechanisms for clonidine reversal of bupivacaine-induced impairment of ventricular conduction in pentobarbital-anesthetized dogs. Anesthesia and analgesia, 1994, Volume: 78, Issue:4 Topics: Animals; Bupivacaine; Carbachol; Clonidine; Dogs; Electrophysiology; Female; Ganglionic Blockers; Heart Conduction System; Hemodynamics; Hexamethonium; Hexamethonium Compounds; Male; Nicotine; Pancuronium; Physostigmine; Receptors, Nicotinic; Yohimbine	1994
Effects of nicotine on brain stem mechanisms of cardiovascular control. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Heart Rate; Hexamethonium; Hexamethonium Compounds; Labetalol; Male; Nicotine; Physostigmine; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley	1993
Prejunctional modulation of nitroxidergic nerve function in canine cerebral arteries. Brain research, 1995, Nov-27, Volume: 700, Issue:1-2 Topics: Acetylcholine; Animals; Calcium; Cerebral Arteries; Clonidine; Dogs; Electric Stimulation; Female; In Vitro Techniques; Magnesium; Male; Morphine; Narcotics; Nicotine; Nitric Oxide; Physostigmine; Vasoactive Intestinal Peptide; Vasodilation	1995
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 1996, Volume: 5, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetaldehyde; Animals; Chromatography, High Pressure Liquid; Clonidine; Corpus Striatum; Ditiocarb; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nicotine; Piperazines; Selegiline; Serotonin	1996
Effect of prior nicotine treatment on drug induced changes in serum LH concentrations in rats. Life sciences, 1997, Volume: 60, Issue:25 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Gonadotropin-Releasing Hormone; Haloperidol; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical	1997
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents. Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10 Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Design; GABA Agonists; Mecamylamine; Mice; Molecular Structure; Muscarinic Antagonists; Nicotine; Nootropic Agents; Piperazines; Piracetam; Pyrroles; Scopolamine	2000
Involvement of adrenergic and cholinergic systems in nicotine-induced anxiogenesis in mice. European journal of pharmacology, 2000, Oct-27, Volume: 407, Issue:1-2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anxiety; Atropine; Clonidine; Hexamethonium; Male; Mecamylamine; Mice; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha-1; Yohimbine	2000
A pervasive mechanism for analgesia: activation of GIRK2 channels. Proceedings of the National Academy of Sciences of the United States of America, 2003, Jan-07, Volume: 100, Issue:1 Topics: Analgesia; Analgesics; Animals; Baclofen; Benzoxazines; Clonidine; Crosses, Genetic; Ethanol; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Mutagenesis; Naphthalenes; Nicotine; Oxotremorine; Pain; Polymerase Chain Reaction; Potassium Channels; Potassium Channels, Inwardly Rectifying; Sex Characteristics	2003
[Smoking, nicotine dependence and detoxification therapies]. Duodecim; laaketieteellinen aikakauskirja, 2002, Volume: 118, Issue:24 Topics: Administration, Cutaneous; Administration, Intranasal; Adrenergic alpha-Agonists; Antidepressive Agents; Bupropion; Chewing Gum; Clonidine; Dopamine Uptake Inhibitors; Health Promotion; Humans; Nicotine; Smoking; Smoking Cessation; Tobacco Use Disorder	2002
Evaluating heterogeneity in cumulative meta-analyses. BMC medical research methodology, 2004, Jul-13, Volume: 4 Topics: Acupuncture; Clonidine; Counseling; Data Interpretation, Statistical; Effect Modifier, Epidemiologic; Humans; Meta-Analysis as Topic; Nicotine; Odds Ratio; Randomized Controlled Trials as Topic; Risk Factors; Smoking Cessation; Tobacco Use Disorder	2004
What to do with a patient who smokes. JAMA, 2005, Jul-27, Volume: 294, Issue:4 Topics: Antidepressive Agents; Bupropion; Central Nervous System Stimulants; Clonidine; Counseling; Hotlines; Humans; Nicotine; Nortriptyline; Physician's Role; Smoking; Smoking Cessation; Tobacco Use Disorder; United States	2005
Persistent exercise attenuates nicotine- but not clonidine-induced antinociception in female rats. Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:4 Topics: Analgesia; Analgesics; Animals; Clonidine; Drug Tolerance; Female; Nicotine; Nicotinic Agonists; Pain; Pain Measurement; Physical Conditioning, Animal; Rats; Rats, Long-Evans; Receptors, Nicotinic	2006
Effects of the CRF receptor antagonist D-Phe CRF(12-41) and the alpha2-adrenergic receptor agonist clonidine on stress-induced reinstatement of nicotine-seeking behavior in rats. Neuropharmacology, 2007, Volume: 53, Issue:8 Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Behavior, Animal; Clonidine; Conditioning, Operant; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Electroshock; Extinction, Psychological; Food Preferences; Male; Nicotine; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Stress, Psychological; Tobacco Use Disorder	2007
[Current and future medical drugs for smoking cessation]. Laryngo- rhino- otologie, 2009, Volume: 88, Issue:6 Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Behavior Therapy; Benzazepines; Bupropion; Cannabinoid Receptor Antagonists; Clinical Trials as Topic; Clonidine; Combined Modality Therapy; Counseling; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Piperidines; Pyrazoles; Quinoxalines; Rimonabant; Smoking Cessation; Tobacco Use Disorder; Vaccines; Varenicline	2009
Potentiated startle as a measure of the negative affective consequences of repeated exposure to nicotine in rats. Psychopharmacology, 2009, Volume: 207, Issue:1 Topics: Acoustic Stimulation; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reflex, Startle; Time Factors; Tobacco Use Disorder	2009
Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptors. Behavioural brain research, 2010, Dec-01, Volume: 213, Issue:2 Topics: Agmatine; Animals; Arginine; Biguanides; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Enzyme Inhibitors; Guanidines; Idazoxan; Male; Mice; Motor Activity; Nicotine; Receptors, Adrenergic, alpha-2; Yohimbine	2010
Current treatment options in smoking cessation. Hospital practice (1995), 2010, Volume: 38, Issue:1 Topics: Adrenergic alpha-Agonists; Antidepressive Agents; Behavior Therapy; Benzazepines; Bupropion; Clonidine; Combined Modality Therapy; Counseling; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Patient Selection; Piperidines; Practice Guidelines as Topic; Pyrazoles; Quinoxalines; Rimonabant; Self-Help Groups; Smoking Cessation; Tobacco Use Disorder; United States; Vaccines; Varenicline	2010
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats. Addiction biology, 2011, Volume: 16, Issue:1 Topics: Animals; Brain; Buspirone; Choice Behavior; Clonidine; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Synergism; Illicit Drugs; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Social Environment; Substance-Related Disorders	2011
Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats. Psychopharmacology, 2010, Volume: 212, Issue:4 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Propranolol; Rats; Rats, Wistar; Reaction Time; Reinforcement, Psychology; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder	2010
Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan. Nutritional neuroscience, 2011, Volume: 14, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anxiety; Apomorphine; Arecoline; Clonidine; Depression; Diet; Dietary Supplements; Emotions; Magnesium; Magnesium Chloride; Magnesium Deficiency; Male; Neurotransmitter Agents; Nicotine; Psychomotor Performance; Rats; Rats, Wistar; Stereotyped Behavior; Vitamin B 6	2011
Smoking cessation pharmacotherapy: a concise overview. Advance for NPs & PAs, 2011, Volume: 2, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Antidepressive Agents; Benzazepines; Bupropion; Clonidine; Humans; Nicotine; Nicotinic Agonists; Nortriptyline; Quinoxalines; Smoking; Smoking Cessation; Varenicline	2011
Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats. Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:1 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; Benzenesulfonates; Clonidine; Electrodes, Implanted; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Quinolines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder	2012
Modulatory effects of the basolateral amygdala α2-adrenoceptors on nicotine-induced anxiogenic-like behaviours of rats in the elevated plus maze. Neuropharmacology, 2016, Volume: 105 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anxiety; Basolateral Nuclear Complex; Clonidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Motor Activity; Nicotine; Nicotinic Agonists; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine	2016