clonidine has been researched along with naloxone in 418 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 229 (54.78) | 18.7374 |
| 1990's | 111 (26.56) | 18.2507 |
| 2000's | 47 (11.24) | 29.6817 |
| 2010's | 23 (5.50) | 24.3611 |
| 2020's | 8 (1.91) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Boettcher, C; Bünemann, M; Dees, C; Lohse, MJ; Nikolaev, VO; Zenk, MH | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cott, J; Engel, J | 1 |
| Margalit, D; Segal, M | 1 |
| Blake, DE; Holsapple, MP; Yim, GK | 1 |
| Paalzow, G; Paalzow, L | 1 |
| Bläsig, J; Herz, A; Laschka, E; Schulz, R | 1 |
| Aghajanian, GK | 1 |
| Agnati, LF; Benfenati, F; Cortelli, P; D'alessandro, R; Ghisoli, E; Zampa, GA | 1 |
| Farsang, C; Kunos, G | 1 |
| Daskalopoulos, N; Laubie, M; Schmitt, H | 1 |
| Rivier, C; Vale, W | 1 |
| Knoll, J; Török, TL; Vizi, SE; Zséli, J | 1 |
| Fielding, S; Lal, H; Spaulding, TC; Venafro, JJ | 1 |
| Bierer, DW; El-Azhary, R; Hanson, SK; Meyer, DR; Robbins, MS; Sparber, SB | 1 |
| Meyer, DR; Sparber, SB | 1 |
| Crawley, JN; Laverty, R; Roth, RH | 1 |
| Harris, RA; Loh, HH; Snell, D; Way, EL | 1 |
| Gomes, C; Svensson, TH; Trolin, G | 1 |
| Harris, R; Loh, HH; Snell, D; Way, EL | 1 |
| Loh, HH; Tseng, LF; Wei, ET | 1 |
| Holdcroft, A; Nicol, ME | 1 |
| Colado, MI; Martin, MI | 1 |
| Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF | 1 |
| Berrino, L; Lampa, E; Maione, S; Rossi, F; Vitagliano, S | 1 |
| Bapna, JS; Ramaswamy, S; Shewade, DG; Tyagi, MG | 1 |
| Ando, R; Kawamura, S; Kimura, Y; Kisara, K; Tadano, T; Yonezawa, A | 1 |
| Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Done, C; Sharp, T; Silverstone, PH | 1 |
| Hylden, JK; Kitto, K; Lei, S; Roerig, SC; Wilcox, GL | 1 |
| Done, C; Sharp, T; Silverstone, P | 1 |
| Dehpour, AR; Ghahremani, MH | 1 |
| Jiang, W; Pearson, KG; Ramirez, JM | 1 |
| Espinoza, M; Flores, R; Ortiz, S; Schnur, P; Vallejos, S; Wainwright, M | 1 |
| Akaike, M; Hirai, M; Kumai, T; Masubuchi, Y; Tanaka, M; Watanabe, M | 1 |
| Arias, L; Bruger, AJ; Gonzalvez, ML; Martinez, JA; Milanés, MV; Vargas, ML | 1 |
| Dawes, P; Rochford, J | 2 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Coupar, IM; Dionyssopoulos, T; Hope, W | 1 |
| Anderson, JA; Edwards, CR; Walker, BR | 1 |
| Schnur, P | 1 |
| Cicero, TJ; Nock, B | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Troian, IuIu; Zhukov, VN | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 1 |
| Kendig, JJ; Maze, M; Savola, MK; Woodley, SJ | 1 |
| Boublik, JH; Brown, MR; Hua, XY; Rivier, JE; Spicer, MA; Yaksh, TL | 1 |
| Morrone, LA; Pimpinella, G; Romanelli, L; Valeri, P | 1 |
| Martinelli, B; Morrone, LA; Severini, C; Valeri, P | 1 |
| Dai, S; Wang, Y | 1 |
| Foo, H; Westbrook, RF | 1 |
| Hoebel, BG; Mark, GP; Pothos, E; Rada, P | 2 |
| Wong, CL | 1 |
| Baranowska, B | 3 |
| Bhandare, PN; D'Souza, RS; Dhume, VG | 1 |
| Barney, CC; Katovich, MJ; Pitman, DL | 1 |
| Henretig, FM; Torrey, SB; Wiley, CC; Wiley, JF | 1 |
| Caffrey, JL; Carter, GC; Hathorne, LF; Sinclair, RJ | 1 |
| Monasky, MS; Stevens, CW; Yaksh, TL; Zinsmeister, AR | 1 |
| Camilleri, M; Malagelada, JR; Thomforde, GM; Yaksh, TL | 1 |
| Alfaro, MJ; Colado, MI; López, F; Martín, MI | 1 |
| Ikeda, M; Koshida, H; Matsubara, T; Miyamori, I; Okamoto, S; Soma, R; Takeda, R | 1 |
| Clark, JT; Smith, ER | 1 |
| Grice, JE; Hockings, GI; Jackson, AJ; Jackson, RV | 1 |
| Dayer, P; Piletta, P; Porchet, HC | 1 |
| Fiser, DH; Moss, MM; Walker, W | 1 |
| Cui, CD; Yin, QZ; Yin, WP; Yu, GD; Zhang, HQ | 1 |
| Buccafusco, JJ | 2 |
| Bell, JA; Kimes, AS; London, ED | 2 |
| Bamshad, MJ; Wasserman, GS | 1 |
| Nance, PW; Sawynok, J | 1 |
| Chang, AP; Dillard, M; Dixon, WR | 1 |
| Beitner, DB; Duman, RS; Nestler, EJ | 1 |
| Hand, TH; Le Moal, M; Stinus, L | 1 |
| Katz, JL | 3 |
| Castelli, A; Maussier, ML; Monaco, F; Roche, J; Saletnich, I; Satta, MA; Scoppola, A; Valenza, V | 1 |
| Ossipov, MH; Spaulding, TC; Suarez, LJ | 1 |
| Abbott, FV; Kunos, G; Mastrianni, JA | 1 |
| Campbell, BF; Pescovitz, OH; Phipps, WR | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Simonato, M; Spalluto, P; Tanganelli, S; Tomasini, C | 1 |
| Henderson, G; Kennedy, C | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Mantzourides, T; Xiang, JZ | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Mantzouridis, T; Xiang, JZ | 1 |
| Bruhn, TO; Jackson, IM; Mueller, GP; Tresco, PA | 1 |
| Hellström, PM; Svensson, TH; Thollander, M | 1 |
| Alamo, C; Alguacil, LF; Cuenca, E; Iglesias, V | 1 |
| Kaur, AH; Srivastava, RK | 1 |
| Edwards, LJ; Wedin, GP | 1 |
| Imura, H; Kato, Y; Koshiyama, H; Shimatsu, A | 1 |
| Gillon, JY; Milne, B; Pujol, JF; Quintin, L | 1 |
| Kirby, DA; Pinto, JM; Verrier, RL | 1 |
| Butkhuzi, SM; Kolchin, VV; Moroz, BT; Sakvarelidze, ZA; Zaĭtsev, AA | 1 |
| Hattori, N; Imura, H; Ishikawa, Y; Kato, Y; Koshiyama, H; Murakami, Y; Shimatsu, A | 1 |
| Kunos, G; Mosqueda-Garcia, R | 3 |
| Barney, CC; Katovich, MJ; Simpkins, JW | 1 |
| Cherkin, A; Flood, JF; Smith, GE | 1 |
| De Lapp, JD; Rhee, HM | 1 |
| Bicknell, RJ; Brown, D; Chapman, C; Zhao, BG | 1 |
| van der Laan, JW | 1 |
| Kulkarni, SK; Parale, MP | 1 |
| Dollery, CT; Struthers, AD | 1 |
| Ben-Zvi, Z; Hurwitz, A | 1 |
| Kameyama, T; Matsuno, K; Nabeshima, T; Sugimoto, A | 1 |
| Kelch, RP; Khoury, SA; Marshall, JC; Reame, NE | 1 |
| Bramnert, M; Hökfelt, B | 3 |
| Al-Saffar, A; Eriksson, U; Hellström, PM; Svensson, TH; Thollander, M | 1 |
| Baranowska, B; Jeske, W; Nowakowski, J; Singh, SP; Soszynski, P | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Clarke, RW; Ford, TW; Taylor, JS | 1 |
| Martinelli, B; Pimpinella, G; Severini, C; Valeri, P | 1 |
| Drayer, JI; Levin, ER; Sharp, B; Weber, MA | 2 |
| Eskay, R; Kunos, G; Mosqueda-Garcia, R; Palkovits, M; Zamir, N | 1 |
| Grosshans, E | 1 |
| Herz, A; Pirke, KM; Schulz, R; Wilhelm, A | 1 |
| Hirose, Y; Kuroda, H; Ogawa, N; Takayama, H | 1 |
| Chandra, A; Diliberto, EJ; Dixon, WR; Holaday, JW; Lewis, JW; Long, JB; Tortella, FC; Unsworth, CD; Viveros, OH; Way, EL | 1 |
| Neal, BS; Sparber, SB | 1 |
| Medvedev, OS | 2 |
| Cleary, JC; da Costa, DF; Mathias, CJ; Peart, S | 1 |
| Gershow, J; Krames, ES; Wilkie, DJ | 1 |
| Lane, LA; McGivern, RF; Noble, EP; Poland, RE | 1 |
| Hölting, T; Limberger, N; Späth, L; Starke, K | 1 |
| Baranowska, B; Cantin, M; Genest, J; Gutkowska, J | 1 |
| Ingenito, AJ; Mastrianni, JA | 1 |
| Dashwood, MR; Dickenson, AH; Sullivan, AF | 1 |
| Esposito, E; Kruszewska, A; Ossowska, G; Samanin, R | 1 |
| Ignar, DM; Kuhn, CM | 1 |
| Elsworth, JD; Garcia, EJ; Grant, SJ; Redmond, DE; Roth, RH; Taylor, JR | 1 |
| Balás-Eltes, A; Farsang, C; Kapocsi, J; Kunos, G; Vajda, L; Varga, K | 2 |
| Ferreira, SH; Nakamura, M | 1 |
| Forsyth, KM; Pollock, D | 1 |
| Derlet, RW; Schlund, J; Weigel, JJ | 1 |
| Ordog, GJ; Wasserberger, J | 1 |
| Gebhart, GF; Solomon, RE | 1 |
| Cook, P | 1 |
| Kuperman, DA; Lynch, DF; Sninsky, CA | 1 |
| Szilagyi, JE | 1 |
| Hoffman, BB; Maze, M; Prokocimer, PG | 1 |
| Baeyens, JM; Esposito, E; Ossowska, G; Samanin, R | 1 |
| Paul, DJ; Sparks, DP; Williams, CA | 1 |
| Duggan, AW; Zhao, ZQ | 1 |
| Abbott, FV; Kunos, G; Mastrianni, JA; Mosqueda-Garcia, R | 1 |
| Artman, M; Boerth, RC; Gremse, DA | 1 |
| Conway, EL | 1 |
| Getzug, T; Murphy, W; Niemann, JT | 1 |
| Adithan, C; Bapna, JS; Shashindran, CH; Sivagnanam, G; Swain, R | 1 |
| Kameyama, T; Matsuno, K; Nabeshima, T; Sugimoto, A; Yamada, S | 2 |
| Addington, S; Exley, RJ; Hempel, AG; Malin, DH | 1 |
| Bueno, L; Primi, MP | 1 |
| Abbott, FV; Kunos, G; Ramirez-Gonzalez, MD; Tchakarov, L | 1 |
| Jacobs, LS; Pénicaud, L; Thompson, DA; Welle, SL | 1 |
| Fuentes, JA; Naranjo, JR | 1 |
| Cervenko, FW; Jhamandas, K; Milne, B; Sutak, M | 1 |
| Holtzman, SG | 1 |
| Brown, OM; DiStefano, PS | 1 |
| Williams, CA | 1 |
| Deguchi, Y; Hanada, S; Kaneto, H | 1 |
| McCulloch, CR; Pollock, D | 1 |
| Kaneto, H; Yamazaki, A | 1 |
| Mohrland, JS; Von Voigtlander, PF | 1 |
| Collier, HO; Tucker, JF | 1 |
| De Jong, W; Petty, MA | 1 |
| Gold, MS; Pottash, AC; Washton, AM | 1 |
| Ginzburg, HM; Glass, WJ | 1 |
| Beubler, E; Bukhave, K; Rask-Madsen, J | 1 |
| Leander, JD | 1 |
| Rawson, RA; Resnick, RB; Tennant, FS; Washton, AM | 2 |
| Farsang, C; Kunos, G; Newman, F; Ungar, W | 1 |
| de Jong, W; Head, GA | 1 |
| Golembiowska-Nikitin, K; Pilc, A; Vetulani, J | 1 |
| Kleber, HD; Riordan, CE | 1 |
| Farsang, C; Kunos, G; Ramirez-Gonzales, MD | 1 |
| Reddy, SV; Yaksh, TL | 1 |
| Chang, PC; Kato, R; Nakaki, T; Tokunaga, Y | 1 |
| Hamilton, TC; Longman, SD | 1 |
| Baum, T; Becker, FT | 1 |
| Bittiger, H; Dooley, DJ | 1 |
| Cerdeño Impuesto, V | 1 |
| Bentley, GA; Newton, SH; Starr, J | 1 |
| Cagliero, E; Isaia, GC; Limone, P; Massara, F; Molinatti, GM; Tagliabue, M | 1 |
| Buvat, J; Buvat-Herbaut, M | 1 |
| Chatelain, P; Claeys, M; Roba, J; van Dorsser, W | 1 |
| Buccafusco, JJ; Marshall, DC; Turner, RM | 1 |
| Livingston, A; Morris, B | 1 |
| Han, JS; Xie, CW | 1 |
| Galloway, MP; Roth, RH | 1 |
| Grant, SJ; Redmond, DE | 1 |
| Farsang, C; Kunos, G; Mucci, L; Ramirez-Gonzalez, MD | 1 |
| Brown, MJ; Dollery, CT; FitzGerald, G; Watkins, J; Zamboulis, C | 1 |
| Kalra, SP; Simpkins, JW | 1 |
| Fielding, S; Lal, H; Spaulding, TC | 1 |
| Aceto, MD; Harris, LS | 1 |
| Extein, IL; Gold, MS; Kleber, HD; Pottash, AC | 1 |
| Gold, MS; Kleber, HD | 1 |
| Huang, YH; Redmond, DE | 1 |
| Farsang, C; Juhasz, I; Kapocsi, J; Kunos, G | 1 |
| Herz, A; Schulz, R; Seidl, E; Wüster, M | 1 |
| Giles, TD; Sander, GE | 1 |
| Collier, HO; Cuthbert, NJ; Francis, DL | 2 |
| Cubeddu, LX; Rogers, JF | 1 |
| Atlas, D; Hynes, MD; Ruffolo, RR | 1 |
| Krystal, JH; Redmond, DE | 1 |
| Chernow, B; Hostinsky, C; Zaloga, GP | 1 |
| Farsang, C; Juhász, I; Kapocsi, J; Kunos, G; Malisák, Z; Vajda, L | 1 |
| Limone, P; Massara, F; Molinatti, GM; Tagliabue, M | 1 |
| Farsang, C; Juhász, I; Kapocsi, J; Kunos, G; Varga, K | 1 |
| Farsang, C; Fekete, M; Kapocsi, J; Kunos, G; Malisak, Z; Vajda, L; Varga, K | 1 |
| Alföldi, S; Farsang, C; Kapocsi, J; Vajda, L; Varga, K | 1 |
| Dackis, CA; Gold, MS; Washton, AM | 1 |
| Manna, C; Piccione, E; Sesti, F | 1 |
| Chandra, A; Chi, ML; Lin, MT; Tsay, BL | 1 |
| Kleber, HD; Kosten, TR | 1 |
| Fregly, MJ; Rowland, N; Wilson, KM | 1 |
| Jelinek, J; Kappen, A; Lomax, P; Schönbaum, E | 1 |
| Tenenbein, M | 1 |
| Bloom, FE; Britton, KT; Koob, GF; Schwartz, J; Svensson, T | 1 |
| Izumi, R; Kaneto, H; Takahashi, M | 1 |
| Tucker, JF | 1 |
| Borrell, J; Fuentes, JA; Naranjo, JR | 1 |
| Aleixandre, MA; García de Jalón, PD; Martin, MI | 1 |
| Ginzburg, HM | 1 |
| Banner, W; Clawson, L; Lund, ME | 1 |
| Blandina, P; Botti, P; Caramelli, L; Fantozzi, R; Ledda, F; Mannaioni, PF; Masini, E; Moroni, F; Peruzzi, S; Zorn, AM | 2 |
| Eisenberg, RM | 1 |
| Michael, RP; Schaefer, GJ | 1 |
| Dwoskin, LP; Neal, BS; Sparber, SB | 1 |
| Livingston, A; Low, J; Morris, B | 1 |
| Mohrland, JS; Wolf, DL | 1 |
| Chan, SH | 1 |
| Brown, MJ; Conway, EL; Dollery, CT | 1 |
| Davies, J; Johnston, SE | 1 |
| Barry, H; Krimmer, EC; McGuire, MS | 1 |
| Extein, I; Gold, MS; Pottash, AL; Stoll, A | 1 |
| Cervo, L; Rochat, C; Romandini, S; Samanin, R | 1 |
| Elsworth, JD; Redmond, DE; Roth, RH | 2 |
| Sanger, DJ | 1 |
| Shropshire, AT; Wendt, RL | 1 |
| Bloor, BC; Flacke, JW; Flacke, WE; Olewine, S | 1 |
| Eriksson, L; Tuomisto, L | 1 |
| Kulig, K; Rumack, BH | 1 |
| Duffy, J; Gaylord, M; Kulig, K; Mauro, R; Rumack, BH | 1 |
| Gupta, VN; Pickworth, WB; Sharpe, LG | 1 |
| Braverman, P; Charney, DS; Heninger, GR; Kleber, HD; Murburg, M; Redmond, DE; Riordan, CE; Sternberg, DE | 1 |
| Fossom, LH; Sparber, SB | 1 |
| Laverty, R; Roth, RH | 1 |
| Lal, H; Shearman, GT; Ursillo, RC | 1 |
| Cervo, L; Mennini, T; Poggesi, E; Rochat, C; Samanin, R | 1 |
| Sharpe, LG; Su, T | 1 |
| Burks, TF; Schreier, WA | 1 |
| Krenzelok, EP; North, DS; Peterson, CD; Wieland, MJ | 1 |
| Morita, K; North, A; Tokimasa, T | 1 |
| Blandina, P; Fantozzi, R; Luciani, G; Mannaioni, P; Masini, E | 1 |
| Banner, W; Clawson, L | 1 |
| Matsievskiĭ, DD; Medvedev, OS; Vylegzhanin, AG | 1 |
| Medvedev, OS; Rozhanskaia, NI; Val'dman, AV | 1 |
| Blandina, P; Luciani, G; Mannaioni, PF; Masini, E | 1 |
| Dmitriev, AV; Ignatov, IuD; Zaĭtsev, AA | 1 |
| Hynes, M; Lal, H; Shearman, GT | 1 |
| van Dongen, PA | 1 |
| Brown, MJ; Dollery, CT; Fitzgerald, GA; Watkins, J; Zamboulis, C | 1 |
| Lipman, JJ; Spencer, PS | 1 |
| Baraban, SC; Guyenet, PG; Stornetta, RL | 1 |
| Alfaro, MJ; Colado, MI; Del Val, V; Lopez, F; Martin, MI | 1 |
| Sanger, GJ; Wardle, KA | 1 |
| Barber, DA; Tackett, RL | 1 |
| Fujimoto, JM; Rady, JJ | 1 |
| Anton, F; Dubner, R; Kenshalo, DR; Thomas, DA; Williams, GM | 1 |
| Gonzalvez, ML; Marín, MT; Martinez-Piñero, MG; Milanés, MV; Vargas, ML | 1 |
| Chakrabarti, MK; Knowles, MG; Wang, C; Whitwam, JG | 1 |
| Agnati, LF; Frasoldati, A; Grimaldi, R; Marrama, P; Pich, EM; Zini, I | 1 |
| Rabkin, SW | 1 |
| Kosten, TA | 1 |
| David, C; Davis, N; Mason, R; Wilson, VG | 1 |
| Onoda, Y; Yamada, K | 1 |
| Dhawan, BN; Kumar, A; Raghubir, R | 1 |
| Dawes, P; Rochford, J; Stewart, J | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Cutler, R; Fishbain, DA; Rosomoff, HL | 1 |
| McCrea, DA; Pearson, KG; Shefchyk, SJ; Stephens, MJ | 1 |
| Ding, H; Wang, C; Zhang, T; Zheng, X | 1 |
| Bonnet, F; Gentili, M | 1 |
| Ibuki, T; Jhamandas, KH; Marsala, M; Yaksh, TL | 1 |
| Hameedi, FA; Kosten, TR; Kreek, MJ; McMahon, TJ; Pearsall, HR; Rosen, MI; Woods, SW | 1 |
| Ammer, H; Schulz, R | 1 |
| Hinton, RK; Kuhn, CM; Little, PJ; Price, RR | 1 |
| Miranda, HF; Naquira, D; Pinardi, G; Sierralta, F | 1 |
| Chieng, B; Christie, MD | 1 |
| Pol, O; Puig, MM; Warner, W | 1 |
| Aley, KO; Levine, JD | 1 |
| Braccia, G; Demaria, PA; Rodgers, C | 1 |
| Horie, S; Watanabe, K; Yamamoto, LT; Yano, S | 1 |
| Berkmiller, G; Falk, W; Frauenholz, T; Herrmann, M; Lang, B; Schölmerich, J; Straub, RH | 1 |
| James, LP; King, WD; Nichols, MH | 1 |
| Asai, T; Mapleson, WW; Power, I | 1 |
| Burden, HW; Davis, MC; Hodson, CA | 1 |
| Asai, T; Power, I; Vickers, MD | 1 |
| Budai, D; Fields, HL | 1 |
| Bersi, C; Comitini, G; Genazzani, AD; Genazzani, AR; Palumbo, M; Petraglia, F; Rubino, S; Santre, M; Santuz, M; Stomati, M | 1 |
| Pinelli, A; Trivulzio, S | 1 |
| Arnsten, AF; Goldman-Rakic, PS | 1 |
| Pinelli, A; Spezia, R; Trivulzio, S | 1 |
| Cancela, LM; Gutiérrez, AC; Keller, EA; Rey, A | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ | 1 |
| Choi, CS; Gevirtz, C; Subhedar, DV | 2 |
| Mason, R; Mundey, MK; Wilson, VG | 1 |
| Elsworth, JD; Punch, LJ; Taylor, JR | 1 |
| Koob, GF; Risbrough, VB; Schulteis, G; Stinus, L | 1 |
| Getslev, V; Pick, CG; Schreiber, S; Weizman, A | 1 |
| Fedirchuk, B; Hultborn, H; Nielsen, J; Petersen, N | 1 |
| Hanson, RM; Hutchins, P; Kappagoda, C; Schell, DN | 1 |
| Gastpar, M; Kaube, H; Kienbaum, P; Klein, S; Peters, J; Scherbaum, N | 1 |
| Ballard, TM; McAllister, KH | 1 |
| Gray, AM; Nevinson, MJ; Sewell, RD | 1 |
| Fukuhara, N; Ishikawa, T; Kinoshita, H; Nakanishi, O; Xiong, L | 1 |
| Botero, M; Enneking, FK | 1 |
| Casarosa, E; Genazzani, AR; Luisi, S; Parrini, D; Petraglia, F; Rubino, S; Spinetti, A; Stomati, M | 1 |
| Hall, JE; Martin, KA; Perkins, RB | 1 |
| Cador, M; Caillé, S; Espejo, EF; Koob, GF; Reneric, JP; Stinus, L | 1 |
| Cutler, DJ; Mason, R; Mundey, MK | 1 |
| Bocchi, C; Delsignore, R; Fontanesi, B; Gerra, G; Rustichelli, P; Timpano, M; Zaimovic, A; Zambelli, U | 1 |
| Rattan, AK; Tejwani, GA | 1 |
| Gyires, K; Müllner, K; Rónai, AZ | 1 |
| Gore, AC; Terasawa, E | 1 |
| Delsignore, R; Di Gennaro, C; Gardini, S; Gerra, G; Giusti, F; Zaimovic, A; Zambelli, U | 1 |
| Arad, MA; Dehpour, AR; Namiranian, K; Samini, M | 1 |
| Casarosa, E; Florio, P; Genazzani, AD; Genazzani, AR; Lombardi, I; Luisi, M; Petraglia, F; Quirici, B | 1 |
| Basbaum, AI; Gilbert, H; Malmberg, AB; Zeitz, KP | 1 |
| Gastpar, M; Heuter, T; Kienbaum, P; Michel, MC; Peters, J; Scherbaum, N | 1 |
| Chahl, LA; Jungnickel, S | 1 |
| Devoto, P; Diana, M; Flore, G; Gessa, GL; Pira, L | 1 |
| Fayaz-Dastgerdi, M; Homayoun, H; Khavandgar, S; Zarrindast, MR | 1 |
| Caillé, S; Espejo, EF; Koob, GF; Stinus, L | 1 |
| Azizi, MR; Dehpour, AR; Farahani, M; Javidan, AN; Namiranian, K; Sadr, SS | 1 |
| Hayashi, M; Hoshi, K; Ichihara, K; Nakai, T; Wakabayashi, H | 1 |
| Seger, DL | 1 |
| García-Barrado, MJ; Iglesias-Osma, MC; Martín, M; Moratinos, J; Rodríguez, R | 1 |
| Lähdesmäki, J; Ozdoğan, UK; Scheinin, M | 1 |
| Caillé, S; De Deurwaerdère, P; Espejo, EF; Koob, GF; Spampinato, U; Stinus, L | 1 |
| Bigelow, GE; Strain, EC; Walsh, SL | 1 |
| Benios, T; Feingold, A; McCance-Katz, E; Oliveto, A; Poling, J; Sevarino, K | 1 |
| Alguacil, LF; Herradón, G; Morales, L; Pérez-García, C | 1 |
| Baraban, JM; Reti, IM | 1 |
| Gewirtz, JC; Harris, AC | 1 |
| Chernes, Y; Pick, CG; Rice, KC; Rigai, T; Schreiber, S | 1 |
| Amass, L; Annon, JJ; Babcock, D; Brigham, G; Buchan, B; Harrer, J; Hillhouse, M; Krejci, J; Ling, W; Muir, J; Orr, D; Reid, M; Shoptaw, S; Woody, G; Ziedonis, D | 1 |
| Caillé, S; Georges, F; Le Moine, C; Stinus, L; Vouillac, C | 1 |
| Fülöp, K; Gyires, K; Rónai, AZ; Zádori, Z | 1 |
| Ali, R; Gowing, L; White, J | 1 |
| Dkhar, SA; Naveen, AT; Peddyreddy, MK; Ramaswamy, S; Shewade, DG | 1 |
| Bearn, J; Best, D; Beswick, T; Gossop, M; McCambridge, J; Rees, S; Strang, J | 1 |
| Behrman, A; Goertemoeller, S | 1 |
| Cechinel-Filho, V; Gurgel, LA; Lima-Júnior, RC; Martins, DT; Rao, VS; Santos, FA | 1 |
| Ozaki, S | 1 |
| Amass, L; Annon, JJ; Babcock, D; Brigham, G; Brown, LS; Buchan, BJ; Cohen, AJ; Horton, T; Krejci, J; Ling, W; Maslansky, R; McCarty, D; Muir, J; Orr, D; Reid, MS; Steinberg, M; Stine, SM; Waite-O'Brien, N; Winhusen, T; Woody, G; Ziedonis, DM | 1 |
| Gyires, K; Zádori, Z | 1 |
| Frishtick, R; Pick, CG; Rubovitch, V; Schreiber, S; Volis, I; Weizman, R | 1 |
| Bein, B; Böhm, R; Gruenewald, M; Höcker, J; Meybohm, P; Ohnesorge, H; Renner, J; Scholz, J | 1 |
| Bilge, SS; Bostanci, MO; Bozkurt, A; Ciftcioglu, E; Dilek, A; Güldogus, F; Ilkaya, F; Ulger, F | 1 |
| Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T | 1 |
| Ali, R; Gowing, L; White, JM | 2 |
| Hosseinzadeh, H; Jahanian, Z | 1 |
| Becker, GL; France, CP; Gerak, LR; Koek, W; Li, JX | 1 |
| Bramness, J; Gossop, M; Lobmaier, P; Waal, H | 1 |
| Heydari, F; Mehr, SE; Samini, M | 1 |
| Andoh, T; Gotoh, Y; Kuraishi, Y; Omori, Y | 1 |
| Cunningham, P; Steele, A | 1 |
| Law, F; Melichar, J; O'Shea, J; Praveen, KT | 1 |
| Etemad, L; Ghazanfari, S; Hosseinzadeh, H; Imenshahidi, M; Moshiri, M | 1 |
| Amato, L; Bellisario, C; Davoli, M; Minozzi, S | 1 |
| Ajaltouni, Z; de Haro, L; Kervégant, M; Schmitt, C; Tauber, M; Tichadou, L | 1 |
| Carrupt, PA; Chapy, H; Cisternino, S; Cruciani, G; Declèves, X; Goracci, L; Parmentier, Y; Scherrmann, JM; Vayer, P | 1 |
| Dong, L; Li, G; Pang, G; Stackman, RW; Wu, X; Xu, S; Zhang, G; Zhang, YM | 1 |
| Allahverdiyev, O; Enginar, N; Nurten, A; Sehirli, I; Türkmen, AZ | 1 |
| Guimera, AL; Kulkarni, D | 1 |
| Heppell, SP; Isbister, GK; Page, CB; Ryan, NM | 1 |
| Loden, JK; Seger, DL | 1 |
| Bigelow, GE; Dunn, KE; Huhn, AS; Schroeder, JR; Strain, EC; Tompkins, DA; Weerts, EM | 1 |
| Nadeau, N; Samuels-Kalow, M; Wilcox, SR; Wittels, K | 1 |
| Andoh, T; Konno, M; Kuraishi, Y; Suzuki, K; Tsuneyama, K | 1 |
| Burns, MM; Freiman, E; O'Donnell, KA; Toce, MS | 1 |
| Adams, A; Copley, C | 1 |
| Beardsley, PM; Carper, M; Contreras, KM; Damaj, MI; Walentiny, DM | 1 |
| Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K | 1 |
| Enginar, N; Gürtekin, B; Midilli, B; Nurten, A; Özdemir-Çezik, S | 1 |
| Downes, MA; Duong, C; Isbister, GK; Lovett, C | 1 |
18 review(s) available for clonidine and naloxone
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Central nervous system mechanisms in blood pressure control.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Disease Models, Animal; Ganglia, Sympathetic; Half-Life; Hypothalamus; Models, Neurological; Naloxone; Neurons; Nitroprusside; Norepinephrine; Phenylethanolamine N-Methyltransferase; Pressoreceptors; Propranolol; Rats; Rats, Inbred SHR; Receptors, Opioid; Reflex; Splanchnic Nerves; Thiophenes; Yohimbine | 1985 |
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pertussis Vaccine; Scopolamine; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Yohimbine | 1984 |
[Narcotic withdrawal syndrome. Therapeutic methods].
Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesia; Brain; Central Nervous System Agents; Clonidine; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1982 |
[New data on the physiology and treatment of vasomotor menopausal flushing].
Topics: Animals; Climacteric; Clonidine; Estrogens; Female; Haplorhini; Humans; Hypothalamic Hormones; Hypothermia; Menopause; Naloxone; Neurotransmitter Agents; Ovary; Rats; Sulpiride; Vasomotor System | 1983 |
Multiple mechanisms of withdrawal from opioid drugs.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Conditioning, Psychological; Cyclic GMP; Dopamine; Drug Tolerance; Enkephalins; Fear; gamma-Aminobutyric Acid; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Norepinephrine; Protein Conformation; Receptors, Opioid; Serotonin; Substance Withdrawal Syndrome | 1984 |
Endogenous opioid peptides: critical care implications.
Topics: Animals; Body Temperature Regulation; Cardiovascular System; Clonidine; Endorphins; Halothane; Humans; Hypotension; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid; Respiration; Shock, Hemorrhagic; Shock, Septic; Shock, Surgical; Spinal Cord; Thyrotropin-Releasing Hormone | 1984 |
The sequential use of clonidine and naltrexone in the treatment of opiate addicts.
Topics: Adult; Baclofen; Clonidine; Drug Therapy, Combination; Electric Stimulation Therapy; Endorphins; Ethanol; Female; Humans; Locus Coeruleus; Male; Methyldopa; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1984 |
[Possibilities and limits of non-hormonal therapy of the menopausal syndrome].
Topics: Bromocriptine; Climacteric; Clonidine; Dopamine; Female; Gonadotropin-Releasing Hormone; Humans; Menopause; Naloxone; Norepinephrine; Prolactin; Sulpiride; Syndrome | 1984 |
Opiate detoxification protocols. A clinical manual.
Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Psychiatric Status Rating Scales; Receptors, Opioid; Substance Withdrawal Syndrome | 1993 |
Clonidine poisoning in Jefferson County, Alabama.
Topics: Alabama; Antihypertensive Agents; Black or African American; Child, Preschool; Clonidine; Female; Humans; Infant; Male; Naloxone; Narcotic Antagonists; Poisoning; Retrospective Studies | 1997 |
Clonidine toxicity revisited.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Clonidine; Drug Overdose; Female; Humans; Hypertension; Infant; Male; Middle Aged; Naloxone; Narcotic Antagonists | 2002 |
Opioid antagonists with minimal sedation for opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2006 |
[Drug dependence syndrome as a side effect of medical drug use].
Topics: Central Nervous System Agents; Clonidine; Flumazenil; Humans; Naloxone; Psychotherapy, Group; Self-Help Groups; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 2007 |
Opioid antagonists with minimal sedation for opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clinical Trials as Topic; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2009 |
The pharmacological treatment of opioid addiction--a clinical perspective.
Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Social Support; Substance Withdrawal Syndrome | 2010 |
Detoxification treatments for opiate dependent adolescents.
Topics: Adolescent; Buprenorphine; Clonidine; Humans; Maintenance Chemotherapy; Naloxone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Dropouts; Randomized Controlled Trials as Topic | 2014 |
Opioid antagonists with minimal sedation for opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clonidine; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Non-Randomized Controlled Trials as Topic; Opioid-Related Disorders; Prospective Studies; Randomized Controlled Trials as Topic; Severity of Illness Index; Substance Withdrawal Syndrome | 2017 |
32 trial(s) available for clonidine and naloxone
| Article | Year |
|---|---|
Objective assessment of clonidine analgesia in man and influence of naloxone.
Topics: Adult; Analgesia; Blood Pressure; Clonidine; Double-Blind Method; Heart Rate; Humans; Naloxone; Pain Measurement; Randomized Controlled Trials as Topic; Regression Analysis; Salivation; Sensory Thresholds | 1990 |
Effect of naloxone on the growth hormone response to clonidine in normal women during the mid-luteal phase.
Topics: Adult; Arcuate Nucleus of Hypothalamus; Clonidine; Estradiol; Female; Growth Hormone; Humans; Hypothalamus; Luteal Phase; Naloxone; Progesterone; Receptors, Opioid | 1989 |
Naloxone enhances the increase in plasma growth hormone induced by alpha 2-adrenergic stimulation in healthy males.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Growth Hormone; Guanfacine; Guanidines; Humans; Male; Naloxone; Phenylacetates; Receptors, Opioid | 1987 |
[Rosacea].
Topics: Body Temperature; Clinical Trials as Topic; Clonidine; Female; Humans; Isotretinoin; Male; Metronidazole; Naloxone; Rosacea; Tetracyclines | 1988 |
The role of the National Institute on Drug Abuse in the development of naltrexone.
Topics: Aftercare; Animals; Carcinogens; Clinical Trials as Topic; Clonidine; Drug Administration Schedule; Drug and Narcotic Control; Drug Evaluation; Drug Evaluation, Preclinical; Female; Humans; Male; Mice; Motivation; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Compliance; Rats; United States; United States Substance Abuse and Mental Health Services Administration | 1984 |
Absence of opiate and histamine H2 receptor-mediated effects of clonidine.
Topics: Adult; Cimetidine; Clonidine; Epinephrine; Humans; Male; Naloxone; Norepinephrine; Receptors, Histamine; Receptors, Histamine H2; Receptors, Opioid | 1980 |
Clinical utility of clonidine in opiate withdrawal: a study of 100 patients.
Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Humans; Methadone; Naloxone; Norepinephrine; Opioid-Related Disorders; Receptors, Adrenergic; Substance Withdrawal Syndrome | 1981 |
Possible involvement of an endogenous opioid in the antihypertensive effect of clonidine in patients with essential hypertension.
Topics: Adult; Blood Pressure; Clonidine; Drug Interactions; Heart Rate; Humans; Hypertension; Middle Aged; Naloxone; Placebos; Receptors, Opioid | 1982 |
Naloxone does not antagonize the antihypertensive effect of clonidine in essential hypertension.
Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Heart Rate; Humans; Hypertension; Male; Naloxone; Posture; Random Allocation; Receptors, Opioid | 1983 |
Failure of naloxone to reduce the clonidine induced reduction of blood pressure and plasma noradrenaline in patients with essential hypertension.
Topics: Adult; Blood Pressure; Clonidine; Female; Humans; Hypertension; Male; Middle Aged; Naloxone; Norepinephrine; Receptors, Opioid; Sodium Chloride | 1983 |
Partial blockade by naloxone of clonidine-induced increase in plasma growth hormone in hypertensive patients.
Topics: Clonidine; Female; Growth Hormone; Humans; Hypertension; Male; Naloxone; Receptors, Opioid | 1984 |
[Hemodynamic effects of naloxone during clonidine treatment of patients with essential hypertension].
Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Drug Antagonism; Female; Hemodynamics; Humans; Hypertension; Male; Naloxone | 1983 |
Reversal by naloxone of the antihypertensive action of clonidine: involvement of the sympathetic nervous system.
Topics: Adult; Blood Pressure; Clonidine; Drug Therapy, Combination; Epinephrine; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Naloxone; Norepinephrine; Renin; Stroke Volume; Sympathetic Nervous System | 1984 |
Effects of clonidine and guanfacine in essential hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Indium; Injections, Intravenous; Middle Aged; Naloxone; Phenylacetates; Radioisotopes; Renin | 1984 |
Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy.
Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1982 |
No evidence for antagonism of clonidine by naloxone in man [proceedings].
Topics: Clonidine; Humans; Male; Naloxone | 1980 |
Spinal clonidine produces less urinary retention than spinal morphine.
Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clonidine; Double-Blind Method; Female; Hip Joint; Humans; Male; Middle Aged; Morphine; Naloxone; Narcotic Antagonists; Urinary Catheterization; Urinary Retention | 1996 |
Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Body Temperature; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone; Male; Naloxone; Substance Withdrawal Syndrome | 1996 |
Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women.
Topics: Administration, Cutaneous; Administration, Oral; Androgen Antagonists; beta-Endorphin; Clonidine; Cohort Studies; Cyproterone; Estradiol; Estrogen Replacement Therapy; Female; Humans; Megestrol; Middle Aged; Naloxone; Narcotic Antagonists; Neurosecretory Systems; Postmenopause; Progesterone; Progesterone Congeners; Sympatholytics; Vaginal Creams, Foams, and Jellies; Vasomotor System | 1997 |
Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anesthesia; Clonidine; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1998 |
Endocrine, neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Androstenedione; Area Under Curve; beta-Endorphin; Climacteric; Clonidine; Dehydroepiandrosterone; Estradiol; Estrone; Female; Fluoxetine; Humans; Middle Aged; Multivariate Analysis; Naloxone; Narcotic Antagonists; Prospective Studies; Radioimmunoassay; Selective Serotonin Reuptake Inhibitors; Somatostatin; Testosterone | 1999 |
Neuroendocrine abnormalities in hypothalamic amenorrhea: spectrum, stability, and response to neurotransmitter modulation.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Amenorrhea; Clonidine; Dopamine Antagonists; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypothalamic Diseases; Longitudinal Studies; Luteinizing Hormone; Metoclopramide; Naloxone; Narcotic Antagonists; Neurosecretory Systems; Neurotransmitter Agents; Sleep | 1999 |
Rapid opiate detoxication in outpatient treatment: relationship with naltrexone compliance.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; GABA Agents; Heroin Dependence; Humans; Inactivation, Metabolic; Ketoprofen; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxazepam; Patient Compliance; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
Lofexidine versus clonidine in rapid opiate detoxification.
Topics: Adult; Analysis of Variance; Clonidine; Double-Blind Method; Humans; Inactivation, Metabolic; Male; Naloxone; Opioid-Related Disorders; Opium; Substance Withdrawal Syndrome; Time Factors | 2001 |
Sympathetic neural activation evoked by mu-receptor blockade in patients addicted to opioids is abolished by intravenous clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Anesthesia; Catecholamines; Clonidine; Electrocardiography; Hemodynamics; Humans; Injections, Intravenous; Male; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid, mu; Sympathetic Nervous System | 2002 |
Evaluation of the effects of lofexidine and clonidine on naloxone-precipitated withdrawal in opioid-dependent humans.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome | 2003 |
Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Clonidine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Surveys and Questionnaires; Yohimbine | 2003 |
A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network.
Topics: Adult; Buprenorphine; Clonidine; Female; Humans; Inactivation, Metabolic; Male; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 2005 |
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Treatment Outcome | 2007 |
Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Anxiety; Buprenorphine; Clonidine; Data Interpretation, Statistical; Depression; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; National Institute on Alcohol Abuse and Alcoholism (U.S.); Opioid-Related Disorders; Prognosis; Smoking; Socioeconomic Factors; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome; United States; Young Adult | 2009 |
A comparison of suboxone and clonidine treatment outcomes in opiate detoxification.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Clonidine; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Patient Dropouts; Quality Improvement; Rehabilitation Centers; Retrospective Studies; Risk; Young Adult | 2012 |
Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes.
Topics: Adult; Analgesics; Buprenorphine; Clonidine; Cluster Analysis; Double-Blind Method; Female; Humans; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Phenotype; Severity of Illness Index; Substance Withdrawal Syndrome; Tramadol; Treatment Outcome | 2020 |
368 other study(ies) available for clonidine and naloxone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.
Topics: Cells, Cultured; Fluorescence Resonance Energy Transfer; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Receptors, Opioid, mu | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Suppression by GABAergic drugs of the locomotor stimulation induced by morphine, amphetamine, and apomorphine: evidence for both pre- and post-synaptic inhibition of catecholamine systems.
Topics: 4-Butyrolactone; Aminobutyrates; Aminooxyacetic Acid; Animals; Apomorphine; Brain; Clonidine; Corpus Striatum; Dextroamphetamine; Diencephalon; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Limbic System; Methyltyrosines; Mice; Morphine; Motor Activity; Naloxone; Norepinephrine; Reserpine; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1977 |
A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Clonidine; Cyproheptadine; Ditiocarb; Electric Stimulation; Fluoxetine; Hydroxydopamines; Locus Coeruleus; Male; Naloxone; Rats; Reserpine; Self Stimulation | 1979 |
Reversible depression of electrically-induced contractions of guinea pig longitudinal muscle by a reversible inhibitor of prostaglandin synthetase.
Topics: Amidines; Animals; Chlorphenamidine; Clonidine; Cyclooxygenase Inhibitors; Guinea Pigs; Indomethacin; Lidocaine; Morphine; Muscle Contraction; Naloxone; Norepinephrine; Phentolamine; Prostaglandins E; Tolazoline | 1979 |
Clonidine antinociceptive activity: effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Atropine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Chlorpromazine; Clonidine; Electroshock; Fenclonine; Lysergic Acid Diethylamide; Male; Methyltyrosines; Naloxone; Parasympathetic Nervous System; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Reserpine; Sympathetic Nervous System; Vocalization, Animal; Yohimbine | 1976 |
Site of naloxone-precipitated opiate withdrawal dissociates from that at which apomorphine reinitiates this phenomenon.
Topics: Animals; Apomorphine; Clonidine; Humans; Injections, Intraventricular; Male; Naloxone; Rats; Receptors, Opioid; Substance Withdrawal Syndrome | 1978 |
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine.
Topics: Action Potentials; Animals; Clonidine; Humans; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naloxone; Neurons; Rats; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Receptors, Opioid; Substance Withdrawal Syndrome | 1978 |
A study on the effects of interaction between naloxone and 2-Br-alpha-ergocryptine or clonidine on luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone levels in normal man serum.
Topics: Adult; Bromocriptine; Clonidine; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Naloxone; Prolactin; Receptors, Opioid; Thyrotropin | 1979 |
Naloxone reverses the antihypertensive effect of clonidine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dihydroergotoxine; Heart Rate; Male; Naloxone; Nitrites; Rats; Receptors, Opioid; Time Factors | 1979 |
[Action of delta 9 tetrahydrocannabinol on the central cardiovascular regulation : mechanism and localization].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cannabis; Cardiovascular System; Cats; Clonidine; Dogs; Dronabinol; Electric Stimulation; Evoked Potentials; Fentanyl; Heart Rate; Hypothalamus; Medulla Oblongata; Morphine Derivatives; Nalorphine; Naloxone; Sciatic Nerve; Splanchnic Nerves; Spleen | 1975 |
Effects of gamma-aminobutyric acid and histamine on prolactin secretion in the rat.
Topics: Aminobutyrates; Animals; Bicuculline; Cells, Cultured; Clonidine; Diphenhydramine; Dopamine; Drug Interactions; Estrogens; gamma-Aminobutyric Acid; Haloperidol; Histamine; Male; Morphine; Naloxone; Nerve Tissue Proteins; Phenoxybenzamine; Pituitary Gland; Progesterone; Prolactin; Rats; Thyrotropin-Releasing Hormone | 1977 |
Effect of prostaglandin E1 and indomethacin on responses of longitudinal muscle of guinea-pig ileum to cholecystokinin.
Topics: Acetylcholine; Animals; Cecum; Cholecystokinin; Clonidine; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Morphine; Muscle Contraction; Naloxone; Norepinephrine; Phentolamine; Prostaglandins E; Tetrodotoxin | 1979 |
Antinociceptive activity of clonidine and its potentiation of morphine analgesia.
Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Male; Mice; Morphine; Naloxone; Reaction Time | 1979 |
Tolerance and dependence after chronic administration of clonidine to the rat.
Topics: Animals; Clonidine; Conditioning, Operant; Drug Tolerance; Humans; Male; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1977 |
Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats.
Topics: Animals; Body Weight; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome | 1978 |
Clonidine reversal of increased norepinephrine metabolite levels during morphine withdrawal.
Topics: Animals; Clonidine; Humans; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Morphine Dependence; Naloxone; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1979 |
Behavioral interactions between naloxone and dopamine agonists.
Topics: Animals; Apomorphine; Behavior, Animal; Clonidine; Drug Synergism; Instinct; Male; Naloxone; Piperazines; Piribedil; Rats; Receptors, Dopamine | 1977 |
Evidence for involvement of central noradrenergic neurons in the cardiovascular depression induced by morphine in the rat.
Topics: Adrenergic Fibers; Animals; Blood Pressure; Brain; Cardiovascular System; Clonidine; Heart Rate; Male; Morphine; Naloxone; Norepinephrine; Protriptyline; Rats; Reflex; Yohimbine | 1976 |
Behavioral interactions of apomorphine, clonidine and naloxone: possible presynatpic involvement.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Clonidine; Drug Interactions; Male; Naloxone; Rats; Reinforcement Schedule; Synapses | 1976 |
Effects of clonidine on morphine withdrawal signs in the rat.
Topics: Anesthesia; Animals; Body Temperature; Cerebral Ventricles; Clonidine; Escape Reaction; Exophthalmos; Humans; Injections; Male; Morphine Dependence; Naloxone; Norepinephrine; Pentobarbital; Piloerection; Rats; Substance Withdrawal Syndrome; Time Factors; Tremor | 1975 |
Density of intrathecal agents.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Baclofen; Body Temperature; Cerebrospinal Fluid; Clonidine; Droperidol; Humans; Methadone; Midazolam; Naloxone; Specific Gravity; Temperature | 1992 |
Effects of opioid and alpha 2-adrenoceptor agonists on the isolated ileum of morphine-dependent guinea-pigs during withdrawal and after clonidine treatment.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Tolerance; Electric Stimulation; Guinea Pigs; Ileum; Male; Morphine; Morphine Dependence; Myenteric Plexus; Naloxone; Narcotics; Neuromuscular Junction; Substance Withdrawal Syndrome; Yohimbine | 1992 |
The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analgesics; Anesthesia; Animals; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Imidazoles; Male; Medetomidine; Naloxone; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord | 1992 |
Participation of arginine vasopressin-mediated and adrenergic system-mediated mechanisms in the hypertension induced by intracerebroventricular administration of NMDA in freely moving rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine Vasopressin; Blood Pressure; Cerebral Ventricles; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; Hypertension; Injections, Intravenous; Injections, Intraventricular; Male; N-Methylaspartate; Naloxone; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains | 1992 |
Further studies on the anti-nociceptive effect of vasopressin.
Topics: Analgesics; Animals; Arginine Vasopressin; Clonidine; Male; Mice; Naloxone; Yohimbine | 1992 |
Chronic clonidine treatment and its termination: effects on penile erection and ejaculation in the dog.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Ejaculation; Imidazoles; Male; Naloxone; Penile Erection; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1992 |
The pressor response to central administration of beta-endorphin results from a centrally mediated increase in noradrenaline release and adrenaline secretion.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Naloxone; Norepinephrine; Rabbits | 1991 |
Clonidine but not nifedipine prevents the release of noradrenaline during naloxone-precipitated opiate withdrawal: an in vivo microdialysis study in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Male; Microdialysis; Morphine Dependence; Naloxone; Nifedipine; Norepinephrine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Weight Loss | 1992 |
Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1992 |
Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Clonidine; Dialysis; Electrochemistry; Hippocampus; Locus Coeruleus; Male; Morphine; Naloxone; Norepinephrine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Developmental changes in morphine and clonidine sensitivity of isolated chick oesophagus.
Topics: Animals; Chickens; Clonidine; Drug Tolerance; Electric Stimulation; Esophagus; Female; In Vitro Techniques; Male; Morphine; Muscle Development; Muscle, Smooth; Naloxone | 1992 |
The use of naloxone to facilitate the generation of the locomotor rhythm in spinal cats.
Topics: Animals; Cats; Clonidine; Decerebrate State; Electromyography; Motor Activity; Naloxone; Physical Stimulation; Skin Physiological Phenomena | 1992 |
Blocking naloxone-precipitated withdrawal in rats and hamsters.
Topics: Animals; Behavior, Animal; Clonidine; Cricetinae; Drug Implants; Mesocricetus; Morphine Dependence; Naloxone; Nifedipine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Verapamil; Yawning | 1992 |
Disturbance or relatively important actions of antihypertensives, antifungal agent and opiate antagonist to the testicular steroidogenesis in rat.
Topics: Androstenedione; Animals; Antifungal Agents; Antihypertensive Agents; Clonidine; Estradiol; Ketoconazole; Male; Naloxone; Narcotic Antagonists; Prazosin; Rats; Testis; Testosterone; Verapamil | 1992 |
Effects of clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal.
Topics: Animals; beta-Endorphin; Clonidine; Female; Hydrocortisone; Male; Morphine Dependence; Naloxone; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Clonidine and yohimbine modulate the effects of naloxone on novelty-induced hypoalgesia.
Topics: Animals; Clonidine; Environment; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Yohimbine | 1992 |
alpha N-acetyl human beta-endorphin-(1-31) alleviates the morphine withdrawal syndrome in rodents: a comparative study with clonidine.
Topics: Animals; beta-Endorphin; Clonidine; Disease Models, Animal; Male; Mice; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine | 1992 |
Effect of adenosine analogues on the expression of opiate withdrawal in rats.
Topics: Adenosine; Animals; Behavior, Animal; Clonidine; Diarrhea; Female; Male; Morphine Dependence; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Clonidine therapy for Shapiro's syndrome.
Topics: Adult; Agenesis of Corpus Callosum; Body Temperature Regulation; Clonidine; Humans; Hyperhidrosis; Hypothermia; Magnetic Resonance Imaging; Male; Naloxone; Syndrome; Water-Electrolyte Imbalance | 1992 |
Morphine withdrawal in the hamster.
Topics: Animals; Clonidine; Cricetinae; Morphine; Naloxone; Nifedipine; Stereotyped Behavior; Substance Withdrawal Syndrome; Verapamil | 1992 |
Morphine suppresses the ovarian steroid hormone-dependent lordosis response of female guinea pigs: reversal by naloxone but not clonidine.
Topics: Animals; Arousal; Brain; Clonidine; Dose-Response Relationship, Drug; Estradiol; Female; Guinea Pigs; Morphine; Naloxone; Neural Inhibition; Norepinephrine; Progesterone; Receptors, Adrenergic; Receptors, Opioid; Sexual Behavior, Animal | 1991 |
Participation of an alpha 2-mediated mechanism in the production of forced swimming-stress induced analgesia in mice.
Topics: Analgesia; Animals; Clonidine; Drug Tolerance; Male; Mice; Naloxone; Physical Exertion; Receptors, Adrenergic, alpha; Stress, Physiological; Swimming; Yohimbine | 1991 |
[Pharmacological regulation of opioidergic antinociceptive mechanisms].
Topics: Animals; Blood-Brain Barrier; Clonidine; Drug Synergism; Endorphins; Male; Mice; Morphine; Naloxone; Pain; Pain Measurement; Receptors, Opioid; Ritanserin | 1991 |
Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn.
Topics: Adrenergic alpha-Agonists; Animals; Anterior Horn Cells; Cats; Clonidine; Drug Interactions; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Alpha 2-adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Animals; Animals, Newborn; Clonidine; Evoked Potentials; Imidazoles; In Vitro Techniques; Medetomidine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex, Monosynaptic; Spinal Cord | 1991 |
The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Injections, Spinal; Male; Motor Activity; Naloxone; Neuropeptide Y; Pain; Parasympathomimetics; Peptide Fragments; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Some pharmacological characteristics of the guinea pig ileum opioid system activated by cholecystokinin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine; Cholecystokinin; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Nifedipine; Receptors, Opioid; Yohimbine | 1990 |
Reproducible withdrawal contractions of isolated guinea-pig ileum after brief morphine exposure: effects of clonidine and nifedipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Nifedipine; Substance Withdrawal Syndrome; Yohimbine | 1990 |
Naloxone-induced cardiovascular depression in rats that had received chronic morphine-treatment.
Topics: Anesthesia; Animals; Arteries; Atropine; Blood Pressure; Cardiac Complexes, Premature; Clonidine; Heart; Hemodynamics; In Vitro Techniques; Male; Morphine; Muscle, Smooth, Vascular; Naloxone; Rats; Rats, Inbred Strains; Tail; Yohimbine | 1991 |
Naloxone-induced hypoalgesia: effects of noradrenergic antagonists and agonist.
Topics: Animals; Clonidine; Hot Temperature; Male; Naloxone; Norepinephrine; Pain; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Sensory Thresholds; Yohimbine | 1991 |
Microdialysis evidence that acetylcholine in the nucleus accumbens is involved in morphine withdrawal and its treatment with clonidine.
Topics: Acetylcholine; Animals; Clonidine; Dialysis; Male; Morphine; Morphine Dependence; Naloxone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1991 |
Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment.
Topics: Analysis of Variance; Animals; Clonidine; Dialysis; Dopamine; Kinetics; Male; Morphine; Naloxone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors | 1991 |
Interaction between the inhibitory effects of morphine and clonidine on intestinal transit in mice.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Female; Gastrointestinal Transit; Intestines; Mice; Mice, Inbred ICR; Morphine; Naloxone; Time Factors; Yohimbine | 1991 |
The effect of clonidine on hormone release mediated through activation of opiate receptors.
Topics: Adult; beta-Endorphin; Clonidine; Female; Growth Hormone; Hormones; Humans; Hydrocortisone; Luteinizing Hormone; Naloxone; Receptors, Opioid | 1990 |
Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action.
Topics: Animals; Cimetidine; Clonidine; Drug Synergism; Ethanol; Male; Naloxone; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Receptors, Opioid; Stomach Ulcer | 1990 |
Mechanisms mediating the thermal response to morphine withdrawal in rats.
Topics: Adrenal Glands; Adrenergic alpha-Agonists; Animals; Body Temperature; Clonidine; Female; Morphine; Naloxone; Propranolol; Rats; Receptors, Adrenergic; Skin Temperature; Substance Withdrawal Syndrome | 1990 |
Clonidine poisoning in young children.
Topics: Atropine; Bradycardia; Charcoal; Child; Child, Preschool; Clonidine; Female; Gastric Lavage; Heart Rate; Humans; Infant; Ipecac; Male; Naloxone; Respiration, Artificial | 1990 |
Naloxone potentiates contractile responses to epinephrine in isolated canine arteries.
Topics: Animals; Clonidine; Corticosterone; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Dynorphins; Epinephrine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Norepinephrine; Peptide Fragments; Phenylephrine; Receptors, Opioid; Renal Artery | 1990 |
Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Injections, Spinal; Male; Morphine; Naloxone; Pain; Parasympathomimetics; Phentolamine; Rats; Rats, Inbred Strains; Reaction Time; Regression Analysis | 1990 |
Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dogs; Drug Interactions; Eating; Gastrointestinal Motility; Injections, Intravenous; Injections, Spinal; Morphine; Naloxone; Phentolamine; Propranolol | 1990 |
Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum.
Topics: Animals; Clonidine; Diltiazem; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Nimodipine; Substance Withdrawal Syndrome | 1990 |
Evaluation of clonidine suppression and various provocation tests in the diagnosis of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Blood Pressure; Clonidine; Epinephrine; Female; Glucagon; Humans; Kinetics; Male; Metoclopramide; Middle Aged; Naloxone; Norepinephrine; Pheochromocytoma | 1990 |
Clonidine suppresses copulatory behavior and erectile reflexes in male rats: lack of effect of naloxone pretreatment.
Topics: Animals; Clonidine; Copulation; Drug Interactions; Male; Naloxone; Penile Erection; Rats; Rats, Inbred Strains; Reflex | 1990 |
Are disturbances in opioid and adrenergic systems involved in the hormonal dysfunction of anorexia nervosa?
Topics: Adult; Anorexia Nervosa; Clonidine; Endorphins; Female; Follicle Stimulating Hormone; Growth Hormone; Hormones; Humans; Hydrocortisone; Luteinizing Hormone; Naloxone; Prolactin; Radioimmunoassay; Sympathetic Nervous System; Thyrotropin-Releasing Hormone | 1990 |
Naloxone-induced ACTH release in man is inhibited by clonidine.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Adult; Clonidine; Corticotropin-Releasing Hormone; Female; Humans; Hydrocortisone; Injections, Intravenous; Male; Middle Aged; Naloxone; Time Factors | 1990 |
Critical care for clonidine poisoning in toddlers.
Topics: Atropine; Child, Preschool; Clonidine; Consciousness; Critical Care; Dopamine; Dose-Response Relationship, Drug; Female; Fluid Therapy; Humans; Infant; Length of Stay; Male; Naloxone; Poisoning; Resuscitation; Retrospective Studies | 1990 |
[Effect of locus coeruleus stimulation and electroacupuncture on nociceptive response of spinal dorsal horn neurons in rats].
Topics: Animals; Clonidine; Electroacupuncture; Female; Locus Coeruleus; Male; Naloxone; Neurons, Afferent; Nociceptors; Phentolamine; Raphe Nuclei; Rats; Rats, Inbred Strains; Spinal Cord | 1990 |
Participation of different brain regions in the anti-narcotic withdrawal action of clonidine in the dependent rat.
Topics: Animals; Blood Pressure; Brain; Clonidine; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1990 |
Clonidine attenuates increased brain glucose metabolism during naloxone-precipitated morphine withdrawal.
Topics: Animals; Autoradiography; Brain; Clonidine; Deoxy Sugars; Deoxyglucose; Image Processing, Computer-Assisted; Male; Morphine; Naloxone; Rats; Rats, Inbred F344; Substance Withdrawal Syndrome | 1990 |
Pediatric clonidine intoxications.
Topics: Clonidine; Humans; Infant; Infant, Newborn; Male; Miosis; Naloxone; Respiratory Distress Syndrome, Newborn; Retrospective Studies; Sleep Stages | 1990 |
Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone.
Topics: Analgesia; Animals; Clonidine; Kinetics; Male; Morphine; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Time Factors; Yohimbine | 1987 |
The effect of clonidine on pituitary hormone secretion in physiological and pathological states.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Clonidine; Cushing Syndrome; Female; Growth Hormone; Humans; Hydrocortisone; Hypertension; Luteinizing Hormone; Menopause; Middle Aged; Naloxone; Pituitary Gland, Anterior; Pituitary Hormones, Anterior | 1987 |
Effect of naloxone on blood pressure responses and plasma catecholamine levels following clonidine injection in conscious, unrestrained rats.
Topics: Animals; Blood Pressure; Catecholamines; Clonidine; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Naloxone; Rats; Rats, Inbred Strains; Time Factors | 1989 |
A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Locus Coeruleus; Male; Morphine; Naloxone; Opioid-Related Disorders; Rats; Rats, Inbred Strains | 1989 |
Differential mechanisms in the acquisition and expression of heroin-induced place preference.
Topics: Animals; Choice Behavior; Clonidine; Dose-Response Relationship, Drug; Heroin; Male; Naloxone; Pimozide; Rats; Rats, Inbred Strains | 1989 |
Interactions of clonidine and naloxone on schedule-controlled behavior in opioid-naive mice.
Topics: Animals; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morphine; Naloxone; Narcotics; Reinforcement Schedule | 1989 |
[Naloxone doesn't determine the response of growth hormone to clonidine in obese patients].
Topics: Adolescent; Adult; Clonidine; Female; Growth Hormone; Humans; Male; Naloxone; Obesity | 1989 |
Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.
Topics: Analgesia; Animals; Clonidine; Drug Interactions; Drug Tolerance; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Spinal Cord | 1989 |
Activation of central mu-opioid receptors is involved in clonidine analgesia in rats.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Species Specificity | 1989 |
Changes in cortical acetylcholine and gamma-aminobutyric acid outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors.
Topics: Acetylcholine; Animals; Clonidine; Dioxanes; Female; gamma-Aminobutyric Acid; Guinea Pigs; Idazoxan; Locus Coeruleus; Male; Morphine; Naloxone; Prazosin; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome | 1989 |
An examination of the putative sigma-receptor in the mouse isolated vas deferens.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Muscle Contraction; Muscle, Smooth; Naloxone; Piperidines; Receptors, Opioid; Receptors, sigma; Vas Deferens | 1989 |
Presynaptic alpha 2-adrenoceptor and kappa-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzofurans; Calcium; Calcium Channels; Clonidine; Dioxanes; Fura-2; Idazoxan; In Vitro Techniques; Male; Mollusk Venoms; Naloxone; Neurons; Nifedipine; omega-Conotoxin GVIA; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptosomes | 1989 |
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Caffeine; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Fluorescent Dyes; Fura-2; Homeostasis; Idazoxan; Male; Naloxone; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Synaptosomes | 1989 |
Beta-endorphin mediates clonidine stimulated growth hormone release.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Endorphins; Growth Hormone; Immune Sera; Male; Naloxone; Rats; Rats, Inbred Strains | 1989 |
Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action.
Topics: Animals; Clonidine; Diarrhea; Gastrointestinal Motility; Intestine, Small; Male; Morphine; Morphine Dependence; Naloxone; Oxymetazoline; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1989 |
An automated method for the evaluation of jumping activity in mice. Effects of clonidine on morphine withdrawal.
Topics: Animals; Clonidine; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Substance Withdrawal Syndrome | 1989 |
Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Desoxycorticosterone; Female; Heart Rate; Hypertension, Renal; Male; Morphine Dependence; Naloxone; Rats | 1989 |
Clonidine poisoning treated with naloxone.
Topics: Adult; Clonidine; Female; Humans; Infusions, Parenteral; Naloxone; Suicide, Attempted | 1989 |
Effects of clonidine and naloxone on the dopamine levels in the rat mediobasal hypothalamus measured by in vivo voltammetry.
Topics: Animals; Clonidine; Dopamine; Electrochemistry; Hypothalamus, Middle; Male; Naloxone; Phenoxybenzamine; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Fentanyl decreases catecholamine metabolism measured by in vivo voltammetry in the rat locus coeruleus.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Catecholamines; Catechols; Clonidine; Fentanyl; Hydrogen-Ion Concentration; Locus Coeruleus; Male; Naloxone; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1989 |
Abolition of clonidine's effects on ventricular refractoriness by naloxone in the conscious dog.
Topics: Animals; Blood Pressure; Clonidine; Dogs; Female; Heart Rate; Male; Naloxone; Reference Values; Time Factors | 1989 |
[Effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord].
Topics: Animals; Cats; Clonidine; Mesencephalon; Naloxone; Neurons; Nociceptors; Pain; Prazosin; Spinal Cord; Yohimbine | 1989 |
Possible involvement of endogenous opioid peptides in prolactin secretion induced by alpha 2-adrenergic stimulation in rats.
Topics: Animals; Cerebral Ventricles; Clonidine; Endorphins; Epinephrine; Injections, Intraventricular; Male; Naloxone; Norepinephrine; Phentolamine; Prolactin; Rats; Rats, Inbred Strains; Reference Values; Thiazines; Xylazine | 1989 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Alpha-adrenergic mediation of the tail skin temperature response to naloxone in morphine-dependent rats.
Topics: Animals; Body Temperature; Brain; Clonidine; Female; Morphine Dependence; Naloxone; Phentolamine; Rats; Receptors, Adrenergic, alpha; Skin Temperature; Tail | 1987 |
Peripheral opiate receptors are not involved in the naloxone-sensitive cardiovascular effects of clonidine in rats.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Heart Rate; Injections, Intravenous; Male; Medulla Oblongata; Microinjections; Naloxone; Oxymorphone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1988 |
Memory enhancement in mice: role of drug dose and training-testing interval.
Topics: Adrenocorticotropic Hormone; Animals; Arecoline; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Fluoxetine; Male; Memory; Memory, Short-Term; Mice; Naloxone; Peptide Fragments; Piribedil; Time Factors | 1988 |
Are opioid receptors involved in the bradycardiac and hypotensive action of clonidine?
Topics: Animals; Blood Pressure; Bradycardia; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Naloxone; Receptors, Opioid; Time Factors | 1988 |
Opioid-noradrenergic interactions in the neurohypophysis. II. Does noradrenaline mediate the actions of endogenous opioids on oxytocin and vasopressin release?
Topics: Animals; Arginine Vasopressin; Clonidine; Electric Stimulation; Endorphins; In Vitro Techniques; Isoproterenol; Male; Naloxone; Norepinephrine; Oxytocin; Pituitary Gland, Posterior; Rats; Receptors, Opioid; Yohimbine | 1988 |
Effects of alpha 2-agonists on morphine withdrawal behaviour: potentiation of jumping mediated by alpha 2-receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Humans; Male; Naloxone; Rats; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome | 1985 |
Apparent pA2 estimates for an antinociceptive receptor.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Mice; Morphine; Naloxone; Nociceptors; Reaction Time; Receptors, Adrenergic, alpha; Yohimbine | 1985 |
Effects of morphine and clonidine on sulphobromophthalein disposition in mice.
Topics: Animals; Bile; Clonidine; Liver; Male; Mice; Morphine; Naloxone; Sulfobromophthalein; Yohimbine | 1986 |
Comparison of alpha-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse.
Topics: Acetates; Adrenergic alpha-Antagonists; Analgesics; Animals; Catecholamines; Clonidine; Male; Mice; Naloxone; Pain; Psychomotor Performance; Reaction Time; Receptors, Adrenergic, alpha; Serotonin | 1986 |
Diurnal patterns of pulsatile luteinizing hormone secretion in hypothalamic amenorrhea: reproducibility and responses to opiate blockade and an alpha 2-adrenergic agonist.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Amenorrhea; Circadian Rhythm; Clonidine; Estradiol; Female; Humans; Hypothalamic Diseases; Luteinizing Hormone; Naloxone | 1987 |
Alpha2-adrenoceptor agonists inhibit the migrating myoelectric complexes of the small intestine in rats.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Gastrointestinal Motility; Intestine, Small; Male; Morphine; Naloxone; Oxymetazoline; Rats; Rats, Inbred Strains | 1987 |
The role of opiate, dopaminergic, and adrenergic systems in the hypothalamo-pituitary dysfunction in obesity.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; beta-Endorphin; Clonidine; Female; Growth Hormone; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Metoclopramide; Naloxone; Obesity; Prolactin; Receptors, Dopamine; Receptors, Opioid | 1987 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Decerebrate State; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Male; Naloxone; Norepinephrine; Rabbits; Reflex; Sural Nerve | 1988 |
Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Piperazines; Substance Withdrawal Syndrome; Triazoles; Yohimbine | 1989 |
Severe hypertension induced by naloxone.
Topics: beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Humans; Hypertension; Male; Middle Aged; Naloxone | 1985 |
Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Glutamates; Heart Rate; Hemodynamics; Hypertension; Medulla Oblongata; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Glutamate | 1986 |
Endogenous opioid peptides: do they mediate the acute antihypertensive action of clonidine in humans?
Topics: Adult; Aged; Aldosterone; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Humans; Hypertension; Male; Middle Aged; Naloxone; Renin | 1986 |
Sex-dependent endorphinergic and adrenergic control mechanisms of luteinizing hormone secretion in immature rats.
Topics: Animals; Castration; Clonidine; Female; Luteinizing Hormone; Male; Naloxone; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Sex Factors; Sexual Maturation; Testosterone | 1985 |
Effects of pentazocine and concomitant clonidine on opioid receptors in the rat brain.
Topics: Animals; Brain; Clonidine; Humans; Male; Naloxone; Opioid-Related Disorders; Pentazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium | 1985 |
Multiple opiate receptors: functional implications.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Azocines; Behavior, Animal; Binding Sites; Blood Pressure; Clonidine; Corticosterone; Enkephalins; Naloxone; Receptors, Opioid; Stress, Physiological; Sympathetic Nervous System | 1985 |
Mianserin attenuates naloxone-precipitated withdrawal signs in rats acutely or chronically dependent upon morphine.
Topics: Animals; Body Temperature; Clonidine; Corticosterone; Dibenzazepines; Male; Mianserin; Morphine Dependence; Naloxone; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Substance Withdrawal Syndrome | 1986 |
[Opiate component in the realization of the vascular effects of clonidine].
Topics: Animals; Blood Pressure; Cats; Clonidine; Female; Hemodynamics; Male; Naloxone; Receptors, Opioid; Vascular Resistance; Vasoconstriction | 1986 |
Naloxone does not affect the cardiovascular, sedative or neurohormonal effects of clonidine in normal and hypertensive man.
Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Hemodynamics; Hormones; Humans; Hypertension; Hypnotics and Sedatives; Male; Middle Aged; Naloxone; Norepinephrine; Pituitary Hormones; Random Allocation; Receptors, Opioid; Renin | 1985 |
Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate.
Topics: Aged; Carcinoma; Clonidine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Spinal; Male; Morphine; Naloxone; Pain, Intractable; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Skull Neoplasms; Spinal Neoplasms; Substance Withdrawal Syndrome; Thyroid Neoplasms | 1986 |
Influence of prenatal ethanol exposure on hormonal responses to clonidine and naloxone in prepubescent male and female rats.
Topics: Animals; Brain; Catecholamines; Clonidine; Corticosterone; Endorphins; Female; Fetal Alcohol Spectrum Disorders; Luteinizing Hormone; Male; Naloxone; Pregnancy; Rats; Rats, Inbred Strains; Sex Factors; Synaptic Transmission | 1986 |
Mutual interaction between presynaptic alpha 2-adrenoceptors and opioid kappa-receptors at the noradrenergic axons of rabbit brain cortex.
Topics: Animals; Axons; Cerebral Cortex; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; Male; Naloxone; Norepinephrine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1986 |
Plasma immunoreactive atrial natriuretic factor (IR-ANF) increases markedly after alpha 2-adrenergic stimulation with clonidine in normally-hydrated rats.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Clonidine; Dose-Response Relationship, Drug; Female; Kinetics; Naloxone; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Urine; Water-Electrolyte Balance | 1987 |
On the relationship between clonidine hypotension and brain beta-endorphin in the spontaneously hypertensive rat: studies with alpha adrenergic and opiate blockers.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Endorphins; Heart Rate; Hypertension; Hypothalamus; Male; Naloxone; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1987 |
Alpha 2-adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine.
Topics: Animals; Autoradiography; Clonidine; Dihydromorphine; Drug Interactions; Electrophysiology; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Yohimbine | 1987 |
Effects of clonidine and morphine on opioid withdrawal in rhesus monkeys.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Morphine; Naloxone; Narcotics; Substance Withdrawal Syndrome | 1986 |
Tolerance to effects of morphine without cross tolerance to effects of clonidine on schedule-controlled behavior of pigeons.
Topics: Animals; Clonidine; Columbidae; Conditioning, Operant; Drug Tolerance; Morphine; Naloxone; Reinforcement Schedule | 1986 |
Noradrenergic and behavioural effects of naloxone injected in the locus coeruleus of morphine-dependent rats and their control by clonidine.
Topics: Animals; Behavior, Animal; Clonidine; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Neurons; Norepinephrine; Rats; Substance-Related Disorders | 1987 |
Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Body Temperature; Catecholamines; Clonidine; Cold Temperature; Corticosterone; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Thyrotropin; Thyrotropin-Releasing Hormone | 1988 |
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Clonidine; Hippocampus; Injections; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1988 |
beta-Endorphin and essential hypertension: importance of the clonidine-naloxone interaction.
Topics: Adult; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Naloxone; Random Allocation | 1985 |
Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances.
Topics: Analgesics; Animals; Carrageenan; Clonidine; Dinoprostone; Drug Tolerance; Enkephalins; Male; Morphine; Naloxone; Peripheral Nerves; Prostaglandins E; Rats; Rats, Inbred Strains; Yohimbine | 1988 |
Endogenous opioid involvement in the cardiovascular effects of clonidine in rats: role of the parasympathetic nervous system.
Topics: Animals; Clonidine; Endorphins; Hemodynamics; Male; Naloxone; Parasympathetic Nervous System; Rats; Rats, Inbred Strains | 1988 |
Clonidine and morphine increase [3H]-noradrenaline overflow in mouse vas deferens.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Morphine; Muscle, Smooth; Naloxone; Norepinephrine; Tetrodotoxin; Vas Deferens | 1988 |
Clonidine overdose and opiate withdrawal.
Topics: Adult; Clonidine; Humans; Hypotension; Male; Naloxone; Substance Withdrawal Syndrome | 1988 |
Naloxone-induced hypertension in patients on clonidine.
Topics: Clonidine; Humans; Hypertension; Naloxone | 1988 |
Intrathecal morphine and clonidine: antinociceptive tolerance and cross-tolerance and effects on blood pressure.
Topics: Animals; Blood Pressure; Clonidine; Drug Administration Schedule; Drug Tolerance; Injections, Spinal; Male; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Reference Values; Spinal Cord; Yohimbine | 1988 |
Increased glucose utilization in superficial layers of the rat spinal dorsal horn during precipitated morphine withdrawal.
Topics: Animals; Clonidine; Glucose; Male; Morphine; Naloxone; Rats; Rats, Inbred F344; Spinal Cord; Substance Withdrawal Syndrome | 1988 |
Clonidine-induced unconsciousness: reversal with naloxone.
Topics: Child, Preschool; Clonidine; Humans; Injections, Spinal; Male; Naloxone; Unconsciousness | 1987 |
Myoelectric activity of the small intestine during morphine dependence and withdrawal in rats.
Topics: Animals; Clonidine; Electromyography; Intestine, Small; Morphine Dependence; Muscle, Smooth; Naloxone; Periodicity; Rats; Substance Withdrawal Syndrome; Xylose | 1987 |
Opioid modulation of baroreceptor reflex sensitivity in dogs.
Topics: Animals; Atropine; Clonidine; Dogs; Endorphins; Hemodynamics; Male; Morphine; Naloxone; Phenylephrine; Pressoreceptors; Reflex; Vagus Nerve | 1987 |
Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Animals; Chlorisondamine; Clonidine; Hypertension; Naloxone; Pheochromocytoma; Rats; Sympathetic Nervous System | 1987 |
Effects of peripheral and central administration of calcium channel blockers in the naloxone-precipitated abstinence syndrome in morphine-dependent rats.
Topics: Animals; Body Weight; Brain; Calcium Channel Blockers; Clonidine; Diarrhea; Flunarizine; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Verapamil | 1987 |
Effects of carotid artery occlusion on the pressor response induced by sustained isometric contraction in the cat.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Carotid Artery Diseases; Cats; Clonidine; Isometric Contraction; Muscle Contraction; Naloxone; Pressoreceptors; Reflex | 1987 |
Clonidine and the hyper-responsiveness of dorsal horn neurones following morphine withdrawal in the spinal cat.
Topics: Animals; Cats; Clonidine; Decerebrate State; Ganglia, Spinal; Injections; Injections, Intravenous; Morphine; Naloxone; Neurons; Substance Withdrawal Syndrome; Substantia Gelatinosa | 1987 |
Endorphinergic mechanism in the central cardiovascular and analgesic effects of clonidine.
Topics: Analgesia; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Endorphins; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity | 1987 |
Hypertension associated with naloxone treatment for clonidine poisoning.
Topics: Blood Pressure; Charcoal; Clonidine; Female; Gastric Lavage; Humans; Infant; Male; Naloxone | 1986 |
Modification of clonidine-induced pressor responses in morphine-dependent and hypophysectomised rats.
Topics: Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Hypertension; Hypophysectomy; Male; Morphine Dependence; Naloxone; Rats; Rats, Inbred SHR | 1986 |
Reversal of clonidine toxicity by naloxone.
Topics: Accidents, Traffic; Aged; Clonidine; Female; Humans; Hypertension; Hypotension; Myocardial Infarction; Naloxone; Wounds, Nonpenetrating | 1986 |
Potentiation of clonidine analgesia by amitriptyline.
Topics: Amitriptyline; Analgesia; Animals; Clonidine; Drug Synergism; Male; Mice; Naloxone; Yohimbine | 1986 |
Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Male; Mice; Morphine; Motor Skills; Naloxone; Pain Measurement; Sleep | 1986 |
Clonidine reverses the behavioral and respiratory effects of continuous naloxone infusion.
Topics: Animals; Behavior, Animal; Clonidine; Male; Naloxone; Oxygen Consumption; Rats; Rats, Inbred Strains | 1986 |
Effects of centrally administered naloxone on gastrointestinal myoelectrical activity in morphine-dependent rats.
Topics: Animals; Atropine; Clonidine; Digestive System; Electrophysiology; Enkephalin, Leucine; Gastrointestinal Motility; Indomethacin; Injections, Intraventricular; Injections, Subcutaneous; Male; Methysergide; Morphine; Naloxone; Phentolamine; Rats; Substance-Related Disorders; Tolazoline | 1987 |
Naloxone reverses the antinociceptive action of clonidine in spontaneously hypertensive rats.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Hypertension; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1985 |
Pharmacological evidence for opioid and adrenergic mechanisms controlling growth hormone, prolactin, pancreatic polypeptide, and catecholamine levels in humans.
Topics: Adolescent; Adult; Catecholamines; Clonidine; Deoxyglucose; Endorphins; Growth Hormone; Humans; Male; Naloxone; Pancreatic Polypeptide; Pituitary Hormones, Anterior; Prolactin; Sympathetic Nervous System | 1985 |
Association between hypoalgesia and hypertension in rats after short-term isolation.
Topics: Animals; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Social Isolation | 1985 |
Intrathecal clonidine: analgesia and effect on opiate withdrawal in the rat.
Topics: Analgesics; Anesthesia, Spinal; Animals; Blood Pressure; Body Temperature; Body Weight; Clonidine; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1985 |
Discriminative stimulus effects of morphine withdrawal in the dependent rat: suppression by opiate and nonopiate drugs.
Topics: Animals; Body Weight; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome | 1985 |
Biochemical correlates of morphine withdrawal. 2. Effects of clonidine.
Topics: Adrenal Glands; Animals; Clonidine; Denervation; Dose-Response Relationship, Drug; Epinephrine; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine | 1985 |
Effect of clonidine and naloxone on the pressor response during contraction of cat hind-limb muscles.
Topics: Animals; Blood Pressure; Cats; Clonidine; Female; Hindlimb; Isometric Contraction; Male; Muscle Contraction; Naloxone | 1985 |
Antinociceptive action of tizanidine in mice and rats.
Topics: Analgesics; Animals; Behavior, Animal; Clonidine; Electric Stimulation; Male; Mice; Mice, Inbred Strains; Motor Skills; Muscle Relaxants, Central; Naloxone; Rats; Rats, Inbred Strains | 1985 |
Diversity of underlying mechanisms in the production of analgesic and pentobarbital-hypnosis prolonging effects of various analgesic drugs and stresses.
Topics: Analgesics; Animals; Clonidine; Electroshock; Hypnotics and Sedatives; Immersion; Male; Mice; Naloxone; Pentobarbital; Stress, Psychological | 1985 |
Effects of chronic drug treatment on the sensitivity of mouse vas deferens to drugs.
Topics: Animals; Carbachol; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Norepinephrine; Potassium Chloride; Vas Deferens | 1985 |
Single dose tolerance to the analgesic effect of clonidine and cross-tolerance between morphine and clonidine.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Male; Mice; Morphine; Naloxone; Time Factors | 1985 |
The analgesic activity of a clonidine analog. The formamidine, U-47,476A.
Topics: Amidines; Analgesics; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypnotics and Sedatives; Mice; Motor Activity; Naloxone; Phentolamine; Rats; Rats, Inbred Strains; Reaction Time; Reserpine; Species Specificity; Time Factors; Yohimbine | 1985 |
Endorphins and the hypotensive response to stimulation of alpha-receptors in the brainstem by alpha-methylnoradrenaline.
Topics: Animals; Blood Pressure; Brain Stem; Clonidine; Endorphins; Enkephalin, Methionine; Immune Sera; Male; Naloxone; Nordefrin; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1984 |
Naltrexone in addicted business executives and physicians.
Topics: Administrative Personnel; Adult; Aftercare; Ambulatory Care; Clonidine; Commerce; Female; Hospitalization; Humans; Male; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Compliance; Physician Impairment | 1984 |
Beta-endorphin contributes to the antihypertensive effect of clonidine in a subset of patients with essential hypertension.
Topics: Adult; beta-Endorphin; Blood Pressure; Clonidine; Drug Interactions; Endorphins; Heart Rate; Humans; Hypertension; Middle Aged; Naloxone | 1984 |
Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat.
Topics: Animals; Atropine; Clonidine; Colon; Cyclic AMP; Diarrhea; Dinoprostone; Female; Humans; Indomethacin; Ketanserin; Morphine Dependence; Naloxone; Piperidines; Prostaglandins E; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome | 1984 |
Kappa opioid agonists and antagonists: effects on drinking and urinary output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins | 1984 |
Clonidine hydrochloride detoxification from methadone treatment--the value of naltrexone aftercare.
Topics: Adult; Aftercare; Attitude to Health; Clonidine; Female; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1984 |
Thyrotropin releasing hormone and naloxone attenuate the antihypertensive action of central alpha 2-adrenoceptor stimulation through different mechanisms.
Topics: Animals; Antihypertensive Agents; Biomechanical Phenomena; Clonidine; Male; Methyldopa; Naloxone; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Stimulation, Chemical; Thyrotropin-Releasing Hormone | 1984 |
Effects of naloxone on the cardiovascular responses to clonidine, alpha-methyldopa and 6-hydroxydopamine in conscious normotensive and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Central Nervous System; Clonidine; Drug Interactions; Endorphins; Hydroxydopamines; Male; Methyldopa; Naloxone; Oxidopamine; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1984 |
Opiates and specific receptor binding of [3H]clonidine.
Topics: Animals; Binding, Competitive; Clonidine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Narcotics; Rats; Receptors, Drug | 1980 |
Rapid opiate detoxification with clonidine and naloxone.
Topics: Clonidine; Humans; Methods; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1980 |
beta-Endorphin: possible involvement in the antihypertensive effect of central alpha-receptor activation.
Topics: Adrenergic alpha-Agonists; Animals; Brain Stem; Clonidine; Disease Models, Animal; Endorphins; Hypertension; Immunoassay; Male; Naloxone; Nordefrin; Rats | 1981 |
Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen.
Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Avoidance Learning; Baclofen; Behavior, Animal; Cats; Clonidine; Drug Interactions; Electroshock; Female; Injections, Spinal; Macaca; Macaca mulatta; Male; Meperidine; Morphine; Naloxone; Narcotics; Pain; Phentolamine; Sensory Thresholds; Spinal Cord | 1981 |
alpha 2-adrenoceptors modulating diarrhoea in morphine-dependent rats.
Topics: Animals; Clonidine; Diarrhea; Humans; Male; Morphine Dependence; Naloxone; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome | 1981 |
A comparison of the cardiovascular and sedative actions of the alpha-adrenoceptor agonists, FLA-136 and clonidine, in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Drug Interactions; Heart Rate; Hemodynamics; Hydroxydopamines; Hypnotics and Sedatives; Injections, Intraventricular; Male; Methohexital; Naloxone; Oxidopamine; Rats; Rats, Inbred Strains; Triazoles; Yohimbine | 1982 |
Alpha-Adrenergic and 5-hydroxytryptaminergic receptor stimulants as new antihypertensive drugs, with observations on involvement of opiate receptors.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid | 1982 |
Characterization of neurotransmitter receptors in the rat hippocampal formation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dihydroalprenolol; Flunitrazepam; Hippocampus; Kinetics; Male; Naloxone; Prazosin; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter | 1982 |
Studies on the antinociceptive action of alpha-agonist drugs and their interactions with opioid mechanisms.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Drug Interactions; Drug Tolerance; Male; Mice; Mice, Inbred BALB C; Naloxone; Oxymetazoline; Receptors, Opioid | 1983 |
Effects of naloxone on the insulin and GH responses to alpha-adrenergic stimulation with clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Blood Glucose; Clonidine; Growth Hormone; Humans; Insulin; Insulin Secretion; Male; Naloxone; Receptors, Opioid | 1983 |
Antihypertensive activity of tibalosine (CP 804 S) in the rat. Possible involvement of a central alpha 1-adrenergic receptor blockade.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Desoxycorticosterone; Female; Heart Rate; Hypertension; Injections, Intravenous; Injections, Intraventricular; Male; Naloxone; Prazosin; Propanolamines; Rats; Rats, Inbred Strains | 1984 |
A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Heart Rate; Humans; Male; Morphine Dependence; Naloxone; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1984 |
Binding of [3H]clonidine to membranes from cow neurohypophysis and cerebral cortex of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Clonidine; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Membranes; Morphine; Naloxone; Narcotics; Pituitary Gland, Posterior; Rats | 1984 |
[Spinal alpha-adrenoceptor and dynorphin involvement in the depressor effect of clonidine].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dynorphins; Female; Heart Rate; Immune Sera; Male; Naloxone; Rats; Receptors, Adrenergic, alpha; Spinal Cord | 1984 |
Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cerebellum; Clonidine; Diazepam; Hippocampus; Kinetics; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Clonidine; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Theophylline | 1982 |
Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Heart Rate; Hypertension; Male; Methyldopa; Morphine; Naloxone; Naltrexone; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Time Factors; Yohimbine | 1980 |
Evidence for noradrenergic mediation of opioid effects on luteinizing hormone secretion.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Castration; Clonidine; Ditiocarb; Estradiol; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Luteinizing Hormone; Morphine; Naloxone; Phenoxybenzamine; Progesterone; Rats | 1981 |
Antinociceptive actions of clonidine.
Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Muridae; Naloxone; Nociceptors; Phenoxybenzamine; Premedication; Receptors, Adrenergic; Receptors, Opioid; Spinal Cord; Yohimbine | 1981 |
Antinociceptive mechanism and acute and chronic behavioral effects of clonidine.
Topics: Animals; Behavior, Animal; Clonidine; Female; Humans; Macaca mulatta; Male; Morphine; Morphine Dependence; Muridae; Naloxone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Substance Withdrawal Syndrome | 1981 |
Neuroanatomical sites of action of clonidine in opiate withdrawal: the locus coeruleus connection.
Topics: Animals; Clonidine; Dopamine; Endorphins; Humans; Locus Coeruleus; Naloxone; Norepinephrine; Opioid-Related Disorders; Panic; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Opioid; Substance Withdrawal Syndrome | 1981 |
The primate locus coeruleus and effects of clonidine on opiate withdrawal.
Topics: Animals; Behavior, Animal; Clonidine; Electric Stimulation; Enkephalins; Fear; Humans; Locus Coeruleus; Macaca; Morphine; Naloxone; Norepinephrine; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 1982 |
Opioid dependence and cross-dependence in the isolated guinea-pig ileum.
Topics: Animals; Clonidine; Drug Tolerance; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Naloxone; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 1982 |
Interactions of leucine-enkephalin with alpha-adrenoceptors in the conscious dog.
Topics: Animals; Blood Pressure; Chemoreceptor Cells; Clonidine; Consciousness; Dogs; Enkephalin, Leucine; Heart Rate; Naloxone; Prazosin; Pressoreceptors; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1983 |
Adaptation of a neuron to normorphine and clonidine.
Topics: Acetylcholine; Animals; Cells, Cultured; Clonidine; Drug Tolerance; Electric Stimulation; Guinea Pigs; Humans; Ileum; Morphine Derivatives; Motor Neurons; Muscle Contraction; Naloxone; Opioid-Related Disorders; Receptors, Adrenergic, alpha; Receptors, Opioid | 1983 |
Antinociceptive activity of N-(4-hydroxyphenacetyl)-4-aminoclonidine, a novel analog of clonidine: role of opioid receptors and alpha-adrenoceptors.
Topics: Analgesics; Animals; Aorta, Thoracic; Benzeneacetamides; Clonidine; Dose-Response Relationship, Drug; Drug Antagonism; Kinetics; Male; Mice; Morphine; Naloxone; Receptors, Adrenergic, alpha; Receptors, Opioid; Xylazine; Yohimbine | 1983 |
[The effect of naloxone on plasma renin activity in patients with essential hypertension treated with clonidine].
Topics: Clonidine; Drug Interactions; Humans; Hypertension; Naloxone; Renin | 1983 |
Failure of naloxone to modify the inhibitory effect of clonidine on insulin secretion.
Topics: Adult; Blood Glucose; Clonidine; Drug Interactions; Humans; Insulin; Insulin Secretion; Male; Naloxone; Time Factors | 1983 |
ABC of poisoning: opioids.
Topics: Clonidine; Humans; Naloxone; Narcotics | 1984 |
Serotoninergic mechanisms of beta-endorphin- and clonidine-induced analgesia in rats.
Topics: 5,6-Dihydroxytryptamine; 5,7-Dihydroxytryptamine; Analgesia; Animals; Brain Chemistry; Clonidine; Endorphins; Fenclonine; Male; Naloxone; Rats; Receptors, Serotonin; Serotonin | 1980 |
Naltrexone induction: psychologic and pharmacologic strategies.
Topics: Ambulatory Care; Behavior Therapy; Clonidine; Counseling; Drug Administration Schedule; Drug Therapy, Combination; Family Therapy; Hospitalization; Humans; Illicit Drugs; Injections, Intramuscular; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Dropouts; Research Design | 1984 |
Drinking: a final common pathway?
Topics: Angiotensin II; Animals; Clonidine; Drinking Behavior; Drug Combinations; Female; Isoproterenol; Male; Naloxone; Rats; Rats, Inbred Strains; Yohimbine | 1984 |
A primate model of human postmenopausal hot flushes.
Topics: Anabolic Agents; Animals; Body Temperature Regulation; Castration; Climacteric; Clonidine; Ethinyl Estradiol; Female; Macaca; Models, Biological; Naloxone; Norpregnenes; Skin Temperature | 1984 |
Naloxone in clonidine toxicity.
Topics: Child, Preschool; Clonidine; Humans; Male; Naloxone | 1984 |
Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidine.
Topics: Animals; Brain Chemistry; Clonidine; Dopamine; Humans; Locus Coeruleus; Male; Morphine Dependence; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1984 |
The role of the catecholaminergic mechanism in foot shock (FS) stress- and immobilized-water immersion (IW) stress-induced analgesia in mice.
Topics: Analgesia; Animals; Catecholamines; Clonidine; Electroshock; Humans; Immersion; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Reserpine; Restraint, Physical; Stress, Psychological | 1984 |
Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Pertussis Toxin; Virulence Factors, Bordetella | 1984 |
Opioid involvement in hypertension induced by short-term isolation.
Topics: Adrenalectomy; Animals; Clonidine; Endorphins; Humans; Hypertension; Male; Naloxone; Naltrexone; Psychophysiologic Disorders; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Social Isolation | 1984 |
Changes in clonidine effect on longitudinal muscle-myenteric plexus strip preparation by morphine treatments.
Topics: Animals; Clonidine; Guinea Pigs; Morphine; Muscle, Smooth; Myenteric Plexus; Naloxone; Prazosin; Yohimbine | 1983 |
Naltrexone and clonidine: alternatives to methadone.
Topics: Clonidine; Humans; Naloxone; Naltrexone; Opioid-Related Disorders | 1983 |
Failure of naloxone to reverse clonidine toxic effect.
Topics: Bradycardia; Child, Preschool; Clonidine; Female; Humans; Hypotension; Infant; Male; Monitoring, Physiologic; Naloxone; Respiration; Time Factors | 1983 |
Overall evaluation of treatment modalities for heroin addiction in a toxicology unit.
Topics: Clonidine; Heroin Dependence; Hospital Units; Humans; Methadone; Morphine; Naloxone; Narcotics; Outcome and Process Assessment, Health Care; Patient Dropouts; Substance Withdrawal Syndrome | 1983 |
Influence of clonidine on the acute dependence response elicited in naive rats by naloxone.
Topics: Animals; Clonidine; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Morphine; Naloxone; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Cardiovascular changes during morphine withdrawal in the rat: effects of clonidine.
Topics: Animals; Behavior, Animal; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1983 |
Morphine withdrawal produces differential effects on the rate of lever-pressing for brain self-stimulation in the hypothalamus and midbrain in rats.
Topics: Animals; Brain; Clonidine; Humans; Hypothalamus; Male; Mesencephalon; Morphine; Naloxone; Rats; Rats, Inbred Strains; Self Stimulation; Substance Withdrawal Syndrome; Time Factors | 1983 |
Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats.
Topics: Animals; Behavior, Animal; Clonidine; Drug Interactions; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance Withdrawal Syndrome; Yohimbine | 1983 |
Effects of clonidine and xylazine on body temperature in the rat.
Topics: Animals; Body Temperature; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Naloxone; Rats; Rats, Inbred Strains; Temperature; Thiazines; Time Factors; Xylazine; Yohimbine | 1984 |
Lateral reticular formation as a site for morphine- and clonidine-induced hypotension.
Topics: Animals; Blood Pressure; Cats; Clonidine; Depression, Chemical; Female; Iontophoresis; Male; Microelectrodes; Microinjections; Morphine; Naloxone; Reticular Formation | 1984 |
Differential effects of clonidine on pain, arterial blood pressure, and heart rate in the cat: lack of interactions with naloxone.
Topics: Animals; Blood Pressure; Cats; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Male; Naloxone; Pain; Reflex | 1984 |
No evidence for involvement of endogenous opioid peptides in effects of clonidine on blood pressure, heart rate and plasma norepinephrine in anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Endorphins; Heart Rate; Hypophysectomy; Morphine; Naloxone; Norepinephrine; Rats | 1984 |
Selective antinociceptive effects of tizanidine (DS 103-282), a centrally acting muscle relaxant, on dorsal horn neurones in the feline spinal cord.
Topics: Amino Acids; Analgesics; Animals; Baclofen; Cats; Clonidine; Electric Stimulation; Female; Injections, Intravenous; Iontophoresis; Male; Muscle Relaxants, Central; Naloxone; Neurons; Norepinephrine; Spinal Cord | 1984 |
Effects of the training dose on generalization of morphine stimulus to clonidine.
Topics: Animals; Clonidine; Conditioning, Operant; Discrimination Learning; Generalization, Stimulus; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Yohimbine | 1984 |
Clonidine hydrochloride detoxification from methadone treatments: the value of naltrexone aftercare.
Topics: Adolescent; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Opium; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1981 |
Clinical utility of clonidine in opiate withdrawal.
Topics: Acute Disease; Adult; Blood Pressure; Clonidine; Humans; Inactivation, Metabolic; Naloxone; Opium; Substance Withdrawal Syndrome | 1981 |
Evidence of a preferential role of brain serotonin in the mechanisms leading to naloxone-precipitated compulsive jumping in morphine-dependent rats.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Humans; Male; Morphine Dependence; Naloxone; Piperoxan; Piribedil; Rats; Serotonin; Substance Withdrawal Syndrome; Sympatholytics | 1981 |
Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.
Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Haplorhini; Humans; Methoxyhydroxyphenylglycol; Morphine Dependence; Naloxone; Neurons; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1982 |
An analysis of the effects of systemically administered clonidine on the food and water intake of rats.
Topics: Animals; Clonidine; Drinking; Drug Interactions; Eating; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Time Factors; Yohimbine | 1983 |
Failure of naloxone to reduce clonidine-induced changes in blood pressure, heart rate and sympathetic nerve firing in cats.
Topics: Animals; Blood Pressure; Cats; Clonidine; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Naloxone; Sympathetic Nervous System | 1983 |
Effects of fentanyl, naloxone, and clonidine on hemodynamics and plasma catecholamine levels in dogs.
Topics: Anesthesia, General; Animals; Atropine; Catecholamines; Clonidine; Dogs; Drug Interactions; Fentanyl; Hemodynamics; Naloxone; Tolazoline | 1983 |
Effect of naloxone on the hypotensive action of clonidine in the conscious, normotensive goat.
Topics: Animals; Behavior, Animal; Blood Pressure; Cardiac Catheterization; Clonidine; Female; Goats; Heart Rate; Naloxone; Respiration; Time Factors | 1983 |
Efficacy of naloxone in clonidine poisoning.
Topics: Clonidine; Humans; Naloxone | 1983 |
Naloxone for treatment of clonidine overdose.
Topics: Apnea; Clonidine; Coma; Female; Humans; Infant; Naloxone | 1982 |
Morphine-like effects of clonidine on the EEG, slow wave sleep and behavior in the dog.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Clonidine; Dogs; Electroencephalography; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Sleep; Yohimbine | 1982 |
Potentiation by naltrexone of d-amphetamine-induced behavioral suppression and its reversal by clonidine.
Topics: Animals; Clonidine; Conditioning, Operant; Dextroamphetamine; Drug Interactions; Male; Naloxone; Naltrexone; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1982 |
Opiate mechanisms in the regulation of the cardiovascular system.
Topics: Animals; Cats; Clonidine; Enkephalins; Hemodynamics; Hypertension; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates.
Topics: Animals; Brain; Brain Chemistry; Chlorocebus aethiops; Clonidine; Drug Interactions; Glycols; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Norepinephrine; Piperoxan | 1982 |
[Medical aspects of opiate addiction].
Topics: Clonidine; Heroin Dependence; Humans; Inpatients; Methadone; Naloxone; Risk | 1982 |
Clonidine reverses the increased norepinephrine turnover during morphine withdrawal in rats.
Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Humans; Male; Methyltyrosines; Morphine Dependence; Naloxone; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1980 |
Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat.
Topics: Animals; Behavior, Animal; Clonidine; Diarrhea; Dose-Response Relationship, Drug; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome | 1980 |
Reduction in the number of serotonin receptors in the brainstem of morphine dependent rats: relation to blockade of naloxone precipitated jumping by serotonin agonists.
Topics: Animals; Behavior, Animal; Brain Stem; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Naloxone; Piperazines; Propranolol; Quipazine; Rats; Receptors, Serotonin; Serotonin; Substance Withdrawal Syndrome | 1980 |
Characteristics of oscillatory contractions elicited by naloxone in ileum preparation from morphine-dependent guinea pigs.
Topics: Acetylcholine; Animals; Clonidine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Naloxone; Neuromuscular Junction | 1980 |
Clonidine dependence in the guinea-pig isolated ileum.
Topics: Animals; Clonidine; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Phentolamine; Propranolol; Substance-Related Disorders | 1981 |
Suppression of morphine withdrawal diarrhea by clonidine.
Topics: Animals; Clonidine; Diarrhea; Digestive System; Female; Humans; Morphine Dependence; Naloxone; Neostigmine; Organ Size; Rats; Substance Withdrawal Syndrome | 1981 |
Naloxone administration in clonidine overdosage.
Topics: Clonidine; Humans; Naloxone | 1981 |
Opiates and clonidine prolong calcium-dependent after-hyperpolarizations.
Topics: Action Potentials; Animals; Calcium; Clonidine; Guinea Pigs; Kinetics; Membrane Potentials; Morphine; Myenteric Plexus; Naloxone; Neurons | 1981 |
Clonidine and naloxone-induced opiate withdrawal: a comparison between clonidine and morphine in man.
Topics: Clonidine; Female; Humans; Male; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1980 |
Failure of narcan to reverse clonidine toxicity.
Topics: Clonidine; Humans; Infant; Male; Naloxone | 1981 |
[Effect of clonidine and naloxone in somatovegetative responses in decerebrate cats].
Topics: Animals; Autonomic Nervous System; Blood Pressure; Cardiac Output; Cats; Clonidine; Decerebrate State; Hemodynamics; Iliac Artery; Naloxone; Vascular Resistance | 1981 |
[Blocking by naloxone of the antihypertensive effect of clonidine in hypertensive and normotensive animals].
Topics: Animals; Blood Pressure; Cats; Clonidine; Hypertension; Naloxone; Rats | 1981 |
Clonidine and naloxone for rapid opiate detoxication: comparison between treatments.
Topics: Clonidine; Female; Humans; Male; Naloxone; Narcotics; Opioid-Related Disorders | 1981 |
[Analgesic effect of clopheline].
Topics: Analgesics; Animals; Behavior, Animal; Cats; Clonidine; Drug Interactions; Hemodynamics; Naloxone; Pain; Papaverine; Rats | 1981 |
Self-administration of clonidine by the rat.
Topics: Animals; Azaperone; Clonidine; Fentanyl; Haloperidol; Infusions, Parenteral; Male; Muridae; Naloxone; Reinforcement Schedule; Self Administration | 1981 |
Locus ceruleus region: effects on behavior of cholinergic, noradrenergic, and opiate drugs injected intracerebrally into freely moving cats.
Topics: Animals; Behavior, Animal; Carbachol; Cats; Clonidine; Female; Locus Coeruleus; Male; Naloxone; Organ Specificity | 1980 |
A comparison of muscarinic cholinergic involvement in the antinociceptive effects of morphine and clonidine in the mouse.
Topics: Animals; Atropine; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morphine; Naloxone; Nociceptors; Oxotremorine; Parasympathetic Nervous System; Physostigmine; Receptors, Cholinergic; Receptors, Muscarinic | 1980 |
Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla.
Topics: Adrenergic Agents; Animals; Autonomic Nervous System; Clonidine; Injections, Intravenous; Iontophoresis; Male; Medulla Oblongata; Morphine; Naloxone; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome | 1995 |
Effect of nimodipine, diltiazem and BAY K 8644 on the behavioural and neurochemical changes associated with naloxone-precipitated withdrawal in the rat. A comparison with clonidine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Behavior, Animal; Brain Chemistry; Clonidine; Diltiazem; Hydroxyindoleacetic Acid; Male; Morphine Dependence; Naloxone; Nimodipine; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Substance Withdrawal Syndrome | 1993 |
Constipation evoked by 5-HT3-receptor antagonism: evidence for heterogeneous efficacy among different antagonists in guinea-pigs.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Clonidine; Colon; Constipation; Defecation; Drug Interactions; Granisetron; Guinea Pigs; In Vitro Techniques; Indoles; Injections, Intraperitoneal; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Serotonin Antagonists; Tropisetron | 1994 |
Opioidergic receptors in the arcuate nucleus are not involved in the cardiovascular effects of clonidine.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Male; Microinjections; Naloxone; Rats; Receptors, Opioid | 1994 |
Dynorphin A(1-17) mediates midazolam antagonism of morphine antinociception in mice.
Topics: Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Dynorphins; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Midazolam; Morphine; Naloxone; Naltrexone; Pain Measurement; Reaction Time; Spinal Cord | 1993 |
Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Electrophysiology; Hot Temperature; Idazoxan; Macaca fascicularis; Macaca mulatta; Male; Medulla Oblongata; Microinjections; Naloxone; Norepinephrine; Pain; Physical Stimulation; Receptors, Opioid | 1993 |
Effects of intracerebroventricular clonidine on the hypothalamic noradrenaline and plasma corticosterone levels of opiate naive rats and after naloxone-induced withdrawal.
Topics: Animals; Clonidine; Corticosterone; Hypothalamus; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Norepinephrine; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Substance Withdrawal Syndrome | 1994 |
Clonidine has comparable effects on spontaneous sympathetic activity and afferent A delta and C-fiber-mediated somatosympathetic reflexes in dogs.
Topics: Animals; Blood Pressure; Clonidine; Dogs; Electric Stimulation; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Injections, Spinal; Kidney; Naloxone; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Reflex; Sympathetic Nervous System; Yohimbine | 1994 |
Involvement of alpha 2-receptors in the analgesia induced by transient forebrain ischemia in rats.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain; Carotid Artery, Common; Clonidine; Dioxanes; Endorphins; Idazoxan; Ischemic Attack, Transient; Male; Methysergide; Naloxone; Norepinephrine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Yohimbine | 1993 |
Comparative effects of central administration of naloxone and clonidine on the blood pressure and heart rate response to anterior and posterior hypothalamic stimulation.
Topics: Animals; Blood Pressure; Clonidine; Heart Rate; Hypothalamus; Imidazoline Receptors; Injections, Intraventricular; Naloxone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Opioid | 1994 |
Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawal.
Topics: Animals; Avoidance Learning; Clonidine; Dose-Response Relationship, Drug; Male; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Effect of naloxone on the habituation of novelty-induced hypoalgesia: the collateral inhibition hypothesis revisited.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Habituation, Psychophysiologic; Male; Morphine; Naloxone; Norepinephrine; Pain; Pain Measurement; Phentolamine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 1993 |
Evidence for functional dissociation of dependence and tolerance in guinea-pig isolated ileal segments following 20 hour exposure to morphine in vitro.
Topics: Animals; Clonidine; Drug Tolerance; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Receptors, Opioid, mu; Temperature | 1993 |
Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion.
Topics: Administration, Oral; Animals; Clonidine; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Loperamide; Male; Mice; Naloxone; Propylamines; Thiophenes; Yohimbine | 1993 |
Analgesic effect of morphine, clonidine and serotonin microinjected into the PTN of rats.
Topics: Analgesics; Animals; Clonidine; Male; Methysergide; Microinjections; Morphine; Naloxone; Pain Measurement; Rats; Serotonin; Superior Colliculi; Yohimbine | 1993 |
Naloxone potentiation of novelty-induced hypoalgesia: characterization of the alpha-noradrenergic receptor subtype.
Topics: Animals; Clonidine; Drug Synergism; Habituation, Psychophysiologic; Male; Naloxone; Pain; Phentolamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine | 1993 |
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1993 |
Disynaptic group I excitation of synergist ankle extensor motoneurones during fictive locomotion in the cat.
Topics: Animals; Cats; Clonidine; Electric Stimulation; Evoked Potentials, Motor; Locomotion; Motor Neurons; Muscle, Skeletal; Naloxone; Neuromuscular Junction; Synaptic Transmission; Tarsus, Animal | 1995 |
Plasma levels of beta-endorphin, leucine enkephalin and arginine vasopressin in patients with essential hypertension and the effects of clonidine.
Topics: Angiotensin II; Antihypertensive Agents; Arginine Vasopressin; beta-Endorphin; Blood Pressure; Clonidine; Enkephalin, Leucine; Female; Heart Rate; Humans; Hypertension; Injections, Intravenous; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neurotensin; Renin; Time Factors | 1995 |
Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine.
Topics: Amino Acids; Animals; Clonidine; Dizocilpine Maleate; Glutamic Acid; Glycine; Injections, Spinal; Male; Microdialysis; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance Withdrawal Syndrome; Taurine; Time Factors | 1996 |
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Animals; Binding, Competitive; Cattle; Clonidine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Muscarinic Agonists; Naloxone; Narcotic Antagonists; Neuroblastoma; Oxotremorine; Pertussis Toxin; Receptors, Opioid, delta; Receptors, Prostaglandin E; Virulence Factors, Bordetella | 1996 |
Role of noradrenergic hyperactivity in neonatal opiate abstinence.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Brain; Clonidine; Humans; Infant, Newborn; Methoxyhydroxyphenylglycol; Naloxone; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; Neurologic Examination; Norepinephrine; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley | 1996 |
alpha-Adrenoceptor and opioid receptor modulation of clonidine-induced antinociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Prazosin; Receptors, Opioid; Yohimbine | 1996 |
Local opioid withdrawal in rat single periaqueductal gray neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Baclofen; Bicuculline; Clonidine; Drug Tolerance; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Male; Membrane Potentials; Morphine; Naloxone; Narcotic Antagonists; Neurons; Organ Culture Techniques; Periaqueductal Gray; Potassium Channels; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Substance Withdrawal Syndrome; Tetrodotoxin; Time Factors; Valine | 1996 |
Interaction of morphine and clonidine on gastrointestinal transit in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Clonidine; Constipation; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Imidazoles; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Sympatholytics | 1996 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine | 1997 |
Propofol for sedation during rapid opiate detoxification.
Topics: Adult; Clonidine; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Male; Naloxone; Opioid-Related Disorders; Oxazepam; Propofol; Substance Withdrawal Syndrome | 1997 |
Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor.
Topics: Acetylcholine; Analgesics; Animals; Clonidine; Diterpene Alkaloids; Electric Stimulation; Guinea Pigs; Histamine; Ileum; Male; Morphine; Muscle Contraction; Naloxone; Neurotransmitter Agents; Nicardipine; Receptors, Opioid; Secologanin Tryptamine Alkaloids; Substance Withdrawal Syndrome | 1997 |
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics; Animals; beta-Endorphin; Clonidine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Interleukin-6; Isoproterenol; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Narcotic Antagonists; Neurons; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid; Spleen | 1997 |
Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Imidazoles; Male; Medetomidine; Morphine; Naloxone; Rats; Rats, Wistar; Yohimbine | 1997 |
Effect of prior nicotine treatment on drug induced changes in serum LH concentrations in rats.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine Antagonists; Drug Administration Schedule; Drug Interactions; Gonadotropin-Releasing Hormone; Haloperidol; Luteinizing Hormone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
Clonidine inhibits gastric motility in the rat.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Gastric Emptying; Male; Naloxone; Rats; Rats, Wistar; Yohimbine | 1997 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Body Temperature; Clonidine; Defecation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pain Threshold; Rats; Rats, Sprague-Dawley; Salivation; Substance Withdrawal Syndrome; Urination | 1997 |
Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism.
Topics: Animals; Benzazepines; Clonidine; Cognition Disorders; Dopamine; Female; Haloperidol; Macaca mulatta; Male; Memory; Naloxone; Noise; Pattern Recognition, Visual; Prefrontal Cortex; Receptors, Dopamine; Stress, Psychological | 1998 |
Effects of tizanidine administration on precipitated opioid withdrawal signs in rats.
Topics: Adrenergic alpha-Agonists; Analgesics; Analysis of Variance; Animals; Behavioral Symptoms; Body Temperature; Clonidine; Disease Models, Animal; Drug Interactions; Male; Morphine; Muscle Relaxants, Central; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pain Threshold; Parasympatholytics; Peristalsis; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Urination | 1998 |
Opiate agonist-induced changes in behavioral sensitivity to clonidine are observed in perinatally malnourished rats exposed to chronic stress.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; beta-Endorphin; Clonidine; Female; Immobilization; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Nutrition Disorders; Opioid Peptides; Pregnancy; Rats; Rats, Wistar; Stress, Physiological | 1998 |
Supraspinal flumazenil inhibits the antianalgesic action of spinal dynorphin A (1-17).
Topics: Analgesia; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Physostigmine | 1998 |
Rapid opioid detoxification.
Topics: Adrenergic alpha-Agonists; Anesthesia; Clonidine; Humans; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 1998 |
Selective potentiation by ouabain of naloxone-induced withdrawal contractions of isolated guinea-pig ileum following acute exposure to morphine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Ouabain; Receptors, Adrenergic, alpha-2; Sodium-Potassium-Exchanging ATPase; Substance Withdrawal Syndrome | 1998 |
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Amygdala; Animals; Clonidine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Locus Coeruleus; Male; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Conditioning, Operant; Male; Morphine; Naloxone; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
The antinociceptive effect of moclobemide in mice is mediated by noradrenergic pathways.
Topics: Analgesics; Animals; Benzamides; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Male; Metergoline; Mice; Mice, Inbred ICR; Moclobemide; Monoamine Oxidase Inhibitors; Morphine; Naloxone; Neural Pathways; Norepinephrine; Receptors, Adrenergic, alpha-2; Serotonin; Yohimbine | 1998 |
Pharmacologically evoked fictive motor patterns in the acutely spinalized marmoset monkey (Callithrix jacchus).
Topics: Animals; Brain Stem; Callithrix; Clonidine; Denervation; Dihydroxyphenylalanine; Dinoprost; Dopamine Agents; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; Female; Femoral Nerve; Locomotion; Male; Mesencephalon; Motor Neurons; N-Methylaspartate; Naloxone; Narcotic Antagonists; Periodicity; Peroneal Nerve; Sciatic Nerve; Serotonin; Spinal Cord; Sympatholytics | 1998 |
Catecholamine surge in opioid-addicted patients undergoing detoxification under general anesthesia.
Topics: Adrenergic alpha-Agonists; Anesthesia, General; Catecholamines; Clonidine; Humans; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 1999 |
Clonidine overdose in childhood: implications of increased prescribing.
Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Bradycardia; Child; Child, Preschool; Clonidine; Drug Overdose; Drug Therapy, Combination; Drug Utilization; Female; Humans; Hypertension; Infant; Male; Naloxone; Narcotic Antagonists; Sleep Stages; Sympatholytics | 1998 |
Acutely administered clozapine does not modify naloxone-induced withdrawal jumping in morphine-dependent mice.
Topics: Analgesics; Animals; Antipsychotic Agents; Clonidine; Clozapine; Haloperidol; Male; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 1999 |
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Central noradrenergic mediation of nitrous oxide-induced analgesia in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Drug Synergism; Idazoxan; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Nitrous Oxide; Rats; Rats, Wistar; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Receptors, Presynaptic; Spinal Cord; Synaptic Transmission | 1998 |
Reversal of prolonged unconsciousness by naloxone after an intravascular injection of a local anesthetic and clonidine.
Topics: Analgesics; Anesthetics, Local; Clonidine; Dicyclomine; Female; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Time Factors | 1999 |
Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal.
Topics: Adrenergic alpha-Agonists; Animals; Avoidance Learning; Brain; Clonidine; Dopamine; Locus Coeruleus; Male; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Neurons; Norepinephrine; Oxidopamine; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome | 1999 |
Electrophysiological effects of opioid receptor activation on Syrian hamster suprachiasmatic nucleus neurones in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Suprachiasmatic Nucleus; Time Factors | 1999 |
Antagonism of antinociception produced by intrathecal clonidine by ketorolac in the rat: the role of the opioid system.
Topics: Adrenergic alpha-Agonists; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Injections, Spinal; Ketorolac; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord | 2000 |
Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Enkephalin, Leucine-2-Alanine; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 2000 |
Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions.
Topics: Animals; Clonidine; Drug Interactions; Female; Fentanyl; Gonadotropin-Releasing Hormone; Guinea Pigs; Luteinizing Hormone; Methysergide; Naloxone; Norepinephrine; Opioid Peptides; Ovariectomy; Periodicity; Quipazine; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine | 2001 |
Clonidine attenuates naloxone-induced opioid-withdrawal syndrome in cholestatic mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholestasis; Clonidine; Disease Models, Animal; Male; Mice; Naloxone; Narcotic Antagonists; Opioid Peptides; Substance Withdrawal Syndrome; Yohimbine | 2001 |
Neuroendocrine effects of raloxifene hydrochloride in postmenopausal women.
Topics: Adrenergic alpha-Agonists; Aged; beta-Endorphin; Clonidine; Drug Interactions; Female; Fluoxetine; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Neurosecretory Systems; Postmenopause; Pregnanolone; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Selective Serotonin Reuptake Inhibitors | 2001 |
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Clonidine; Drug Tolerance; Hyperalgesia; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Pain Measurement; Protein Kinase C | 2001 |
The effect of clonidine on the naltrexone-induced withdrawal response in morphine-treated guinea-pigs.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Female; Genes, fos; Guinea Pigs; Male; Morphine Dependence; Naloxone; Narcotic Antagonists | 2002 |
Co-release of noradrenaline and dopamine in the prefrontal cortex after acute morphine and during morphine withdrawal.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine; Dopamine Agonists; Extracellular Space; Locus Coeruleus; Male; Morphine; Naloxone; Narcotics; Norepinephrine; Parietal Lobe; Prefrontal Cortex; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Somatosensory Cortex; Time Factors; Ventral Tegmental Area | 2002 |
The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arginine; Clonidine; Enzyme Inhibitors; Male; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Substance Withdrawal Syndrome; Yohimbine | 2002 |
Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome.
Topics: 5,7-Dihydroxytryptamine; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Biogenic Amines; Clonidine; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Substance Withdrawal Syndrome; Weight Loss | 2002 |
Lithium inhibits the development of physical dependence to clonidine in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Clonidine; Injections, Intraperitoneal; Lithium; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Substance-Related Disorders; Yohimbine | 2002 |
Noradrenaline release in rat locus coeruleus is regulated by both opioid and alpha(2) -adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Injections, Intraventricular; Locus Coeruleus; Male; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Substance Withdrawal Syndrome; Yohimbine | 2002 |
Role of mu-opioid receptors in insulin release in the presence of inhibitory and excitatory secretagogues.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Female; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Naloxone; Quinoxalines; Receptors, Opioid, mu; Somatostatin | 2002 |
Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Pain; Prazosin; Substance Withdrawal Syndrome; Weight Loss | 2003 |
Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats.
Topics: Animals; Avoidance Learning; Clonidine; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Morphine Dependence; Naloxone; Rats; Rats, Sprague-Dawley; Serotonin; Synaptic Transmission | 2003 |
The contribution of alpha2-adrenoceptor and opioid receptor mechanisms to antinociception differs in Lewis and Fischer 344 rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Female; Morphine; Naloxone; Pain Threshold; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Species Specificity; Time Factors; Yohimbine | 2003 |
Opiate withdrawal induces Narp in the extended amygdala.
Topics: Amygdala; Analgesics; Animals; C-Reactive Protein; Cell Count; Clonidine; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Nucleus Accumbens; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance Withdrawal Syndrome | 2003 |
Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety.
Topics: Acoustic Stimulation; Acute Disease; Animals; Chlordiazepoxide; Clonidine; Disease Models, Animal; Injections, Intravenous; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome; Time Factors | 2004 |
The antinociceptive effect of zolpidem and zopiclone in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Agonists; Adrenergic Antagonists; Analgesics; Animals; Azabicyclo Compounds; Behavior, Animal; Benzamides; Clonidine; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Piperazines; Pyridines; Receptors, Opioid; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Zolpidem | 2005 |
Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Avoidance Learning; Behavior, Animal; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Imidazoline Receptors; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2005 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastric Emptying; Gastric Mucosa; Gastrointestinal Motility; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Oxymetazoline; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Stomach Ulcer; Yohimbine | 2005 |
An inherent acceleratory effect of insulin on small intestinal transit and its pharmacological characterization in normal mice.
Topics: Animals; Atropine; Calcium Channels; Clonidine; Gastrointestinal Transit; Glyburide; Insulin; Insulin Secretion; Intestine, Small; Male; Mice; Naloxone; Ondansetron; Receptors, Opioid; Verapamil | 2006 |
A sticky situation: toxicity of clonidine and fentanyl transdermal patches in pediatrics.
Topics: Accidents; Administration, Cutaneous; Analgesics, Opioid; Antihypertensive Agents; Clonidine; Coma; Drug Overdose; Emergency Treatment; Fentanyl; Humans; Infant; Naloxone; Narcotic Antagonists; Patient Education as Topic; Seizures; Self Administration | 2007 |
Dragon's blood from Croton urucurana (Baill.) attenuates visceral nociception in mice.
Topics: Abdominal Pain; Acetylcysteine; Administration, Oral; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Capsaicin; Clonidine; Croton; Cyclophosphamide; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Pentobarbital; Plant Extracts; Sleep; Time Factors | 2007 |
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer | 2008 |
The antinociceptive properties of reboxetine in acute pain.
Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu | 2009 |
Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Autoradiography; Binding, Competitive; Brain; Clonidine; Drug Partial Agonism; Female; Fentanyl; In Vitro Techniques; Male; Mice; Mice, Knockout; Morphine; Naloxone; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu | 2009 |
The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Catheterization; Clonidine; Colon; Data Interpretation, Statistical; Dexmedetomidine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Rectum; Yohimbine | 2009 |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Indoles; Loperamide; Male; Mice; Mice, Inbred Strains; Mustard Plant; Naloxone; Plant Oils; Transient Receptor Potential Channels; TRPA1 Cation Channel; Yohimbine | 2009 |
Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice.
Topics: Animals; Carotenoids; Clonidine; Crocus; Cyclohexenes; Male; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Plant Extracts; Substance Withdrawal Syndrome; Terpenes | 2010 |
Precipitated and conditioned withdrawal in morphine-treated rats.
Topics: Animals; Body Weight; Clonidine; Conditioning, Classical; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2010 |
alpha(1)- and alpha(2)-Adrenoceptor hyporesponsiveness in isolated bisected vas deferens of bile duct-ligated rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Bile Ducts, Extrahepatic; Cholestasis, Extrahepatic; Clonidine; Electric Stimulation; In Vitro Techniques; Ligation; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vas Deferens; Yohimbine | 2010 |
Tonic inhibition of allergic itch signaling by the descending noradrenergic system in mice.
Topics: Animals; Bites and Stings; Clonidine; Culicidae; Histamine Antagonists; Hypersensitivity; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Norepinephrine; Pruritus; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Spinal Cord; Yohimbine | 2011 |
Opioid dependence.
Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prognosis; Risk Factors; Substance Withdrawal Syndrome; Time Factors | 2012 |
Effect of cyanocobalamin (vitamin B12) in the induction and expression of morphine tolerance and dependence in mice.
Topics: Analgesics, Opioid; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Male; Memantine; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Vitamin B 12 | 2014 |
[Clonidine poisoning in a child: a case report].
Topics: Adrenergic alpha-2 Receptor Agonists; Albuterol; Antihypertensive Agents; Betaxolol; Blood Pressure; Child; Clonidine; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Overdose; Drug Therapy, Combination; Heart Rate; Humans; Male; Medication Errors; Naloxone | 2014 |
Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line.
Topics: Antiporters; Brain; Cell Line; Clonidine; Cocaine; Endothelial Cells; Humans; Naloxone; Protons; Receptors, Drug | 2015 |
Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in heroin-treated mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Behavior, Animal; Benzazepines; Central Nervous System Stimulants; Clonidine; Heroin; Male; Mice; Motor Activity; Naloxone; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Agonists; Substance Withdrawal Syndrome | 2015 |
Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences.
Topics: Analgesics; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Grooming; Male; Mice, Inbred BALB C; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Rats, Wistar; Sex Factors; Substance Withdrawal Syndrome | 2015 |
Altered Mental Status in a 14-Year-Old Girl.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Clonidine; Diagnosis, Differential; Drug Overdose; Enema; Female; Humans; Intestines; Naloxone; Narcotic Antagonists; Psychoses, Substance-Induced; Therapeutic Irrigation | 2016 |
Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but not severe toxicity.
Topics: Adolescent; Adult; Aged; Antidotes; Antihypertensive Agents; Atropine; Bradycardia; Central Nervous System Diseases; Clonidine; Drug Overdose; Female; Glasgow Coma Scale; Humans; Length of Stay; Male; Middle Aged; Naloxone; Retrospective Studies; Young Adult | 2017 |
Naloxone reversal of clonidine toxicity: dose, dose, dose.
Topics: Adolescent; Antidotes; Antihypertensive Agents; Child; Child, Preschool; Clonidine; Cohort Studies; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Hypertension; Infant; Male; Naloxone; Retrospective Studies | 2018 |
A Common Antidote for an Uncommon Indication.
Topics: Antidotes; Bradycardia; Child, Preschool; Clonidine; Consciousness Disorders; Eating; Emergency Service, Hospital; Female; Humans; Mental Status and Dementia Tests; Naloxone; Sleepiness | 2019 |
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Animals; Antipruritics; Bile Ducts; Cholestasis; Clonidine; Disease Models, Animal; Ligation; Liver; Male; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa | 2020 |
Clinical Effects of Pediatric Clonidine Exposure: A Retrospective Cohort Study at a Single Tertiary Care Center.
Topics: Adolescent; Adult; Child; Clonidine; Cohort Studies; Humans; Naloxone; Retrospective Studies; Tertiary Care Centers; Young Adult | 2021 |
High dose naloxone for acute tizanidine overdose in the emergency department: a case report.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Drug Overdose; Emergency Service, Hospital; Female; Humans; Hyperglycemia; Naloxone | 2021 |
Validation and characterization of oxycodone physical dependence in C57BL/6J mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice, Inbred C57BL; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Substance Withdrawal Syndrome | 2021 |
Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.
Topics: Analgesics; Animals; Atropine Derivatives; Clonidine; Formaldehyde; Humans; Hyperalgesia; Naloxone; Narcotic Antagonists; Neostigmine; Pain; Pentazocine; Rats; Rats, Sprague-Dawley | 2022 |
Effect of oxytocin pretreatment on the development of morphine tolerance and dependence in rats.
Topics: Animals; Clonidine; Drug Tolerance; Morphine; Morphine Dependence; Naloxone; Oxytocin; Rats; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome | 2022 |
Reality of clonidine poisoning in children and adolescents.
Topics: Adolescent; Atropine; Bradycardia; Child; Child, Preschool; Clonidine; Female; Humans; Hypotension; Male; Naloxone; Poisoning; Retrospective Studies | 2023 |