clonidine and moxonidine

clonidine has been researched along with moxonidine in 95 studies

Research

Studies (95)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (5.26)	18.7374
1990's	40 (42.11)	18.2507
2000's	36 (37.89)	29.6817
2010's	14 (14.74)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Arasasingham, PN; Burke, JE; Garst, ME; Hasson, DW; Kharlamb, AB; Lai, RK; Manlapaz, CA; Munk, SA; Padillo, EU; Wheeler, LA; Wijono, MK	1
Arrault, A; Guillaumet, G; Mérour, JY; Pfeiffer, B; Renard, P; Rettori, MC; Scalbert, E; Touzeau, F	1
Harms, GS; Lohse, MJ; Steinmeyer, R; Vilardaga, JP	1
Lombardo, F; Obach, RS; Waters, NJ	1
Agbaba, D; Filipic, S; Nikolic, K	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Bousquet, P; Ehrhardt, JD; Feldman, J; Fellmann, L; Gasparik, V; Greney, H; Schann, S	1
Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J	1
Elliott, HL; Howie, CA; Macphee, GJ; Reid, JL	1
Armah, BI; Göthert, M; Schlicker, E	1
Ramage, AG; Wilkinson, SJ	1
Armah, BI	1
Armah, BI; Hofferber, E; Stenzel, W	1
Plänitz, V	2
Breslin, DS; Ernsberger, P; Felsen, D; Marion, DN; May, M; Nejat, RJ; Nguyen, P; Sutaria, PM; Vaughan, ED	1
Dreshaj, I; Ernsberger, P; Haxhiu, MA; Schäfer, SG	1
Dhalla, KS; Dhalla, NS; Rupp, H	1
Bamberger, CM; Gödde, E; Mill, G; Mönig, H; Schulte, HM	1
Elliott, HL; MacPhee, G; Panfilov, V; Reid, JL	1
Glavin, GB; Smyth, DD	1
Christen, MO; Collins, LA; Dreshaj, I; Ernsberger, P; Graff, LM; Graves, ME; Grove, DL; Haxhiu, MA; Schäfer, SG	1
Ernsberger, P; Furin, J; Liedtke, CM	1
Christen, O; Göthert, M; Molderings, GJ; Schäfer, SG	1
Bohmann, C; Rump, LC; Schollmeyer, P	1
Christen, MO; Damon, TH; Ernsberger, P; Graff, LM; Schäfer, SG	1
Chan, CK; Head, GA; Sannajust, F	1
Chan, CK; Head, GA	1
Brilla, CG; Maisch, B; Rupp, H	1
Koch, HF; Webster, J	1
Göthert, M; Likungu, J; Molderings, GJ	1
Darkwa, FK; Smyth, DD	1
Ernsberger, P; Friedman, JE; Koletsky, RJ	1
Gleichmann, H; Ohly, P; Rösen, P	1
Chan, CK; Godwin, SJ; Head, GA	1
Fink, K; Göthert, M; Kathmann, M; Molderings, GJ; Schlicker, E	1
Greven, J; Hohage, H; Schlatter, E	1
Piletz, JE; Reis, DJ	1
Greven, J; Hess, K; Hohage, H; Jahl, C; Schlatter, E	1
Kunduzova, OR; Medvedev, OS; Medvedeva, NA; Murashev, AN	3
Godwin, SJ; Head, GA; Parkin, ML; Tortelli, CF	1
Chung, O; Culman, J; Haass, M; Nurminen, ML; Unger, T	1
Blue, DR; Dillon, MP; Eglen, RM; Jasper, JR; Lesnick, JD; MacLennan, SJ; Zhu, QM	1
Greven, J; Hohage, H; Matzkies, F; Mehrens, T; Steinmetz, M	1
Drzewoski, J; Wiśniewska-Jarosińska, M	1
Bock, C; Niederhoffer, N; Nordheim, U; Szabo, B	1
Head, GA	1
Esteban, S; García-Sevilla, JA; Sastre-Coll, A	1
Peters, SL; Van Zwieten, PA	1
Robles, NR	1
Lutz, EA; Shannon, HE	1
Baldwin, J; Chang, CH; Ernsberger, P; Gold, G; Ivanov, TR; Jones, JC; Pickard, RT; Piletz, JE; Reis, DJ; Roth, B; Sharp, JD; Zhu, H	1
Fairbanks, CA; Grocholski, BM; Nguyen, HO; Wilcox, GL	1
Dendorfer, A; Dominiak, P; Raasch, W	1
Gandía, L; García, AG; Hernández-Guijo, JM; Jurkiewicz, A; Olivares, R; Ruiz-Nuño, A; Santos, WC	1
Fritz, T; Szabo, B; Wedzony, K	1
Bourbon, N; Edwards, L; Ernsberger, P; Fishman, D; Horowitz, P; Kester, M	1
Mest, HJ; Scheltdorf, M	1
Kobilka, BK; Limbird, LE; MacMillan, LB; Tan, CM; Wilson, MH	1
Penner, SB; Smyth, DD	1
Lechin, F; Lechin, M; van der Dijs, B	1
Godwin, SJ; Head, GA; Parkin, ML	1
Garcez-do-Carmo, L; Jurkiewicz, A; Piçarro, I; Santos, WC; Smaili, SS	1
Ernsberger, P; Velliquette, RA	1
Dukhanin, AS; Galenko-Yaroshevskii, AP; Ponomarev, VV	1
Amelin, AV; Ignatov, IuD; Skoromets, AA	1
Ren, LM; Zhao, D	1
Cao, C; Kang, CW; Kim, SH; Kim, SZ	1
El-Ayoubi, R; Gutkowska, J; Menaouar, A; Mukaddam-Daher, S	1
Burke, SL; Chan, CK; Head, GA; Piletz, JE; Zhu, H	1
Ernsberger, P; Kossover, R; Previs, SF; Velliquette, RA	1
Gutkowska, J; Menaouar, A; Mukaddam-Daher, S	1
Gabilan, NH; Rodrigues, AL; Rosa, AO; Zeidan, MP; Zomkowski, AD	1
Sica, DA	1
Bönisch, H; Brüss, M; Göthert, M; Molderings, GJ; von Kügelgen, I; Wolf, C	1
Su, DF; Wang, LG; Wang, WZ; Yuan, WJ; Zeng, J	1
Liu, AJ; Ma, XJ; Shen, FM; Shi, KY; Su, DF; Wu, YL	1
Guertin, PA; Lapointe, NP; Rouleau, P; Ung, RV	1
Lu, HG; Ren, LM; Zhang, X; Zhao, D	1
Hashimoto, M; Ono, H; Tanabe, M	1
Centurión, D; Cobos-Puc, LE; Márquez-Conde, JA; Monroy-Ordoñez, EB; Sánchez-López, A; Villalón, CM	1
Bousquet, P; Lessa, MA; Nascimento, AR; Sabino, B; Tibiriçá, E	1
Chopde, CT; Kotagale, NR; Patel, MR; Shelkar, GP; Taksande, BG; Ugale, RR	1
Grishin, OV; Ruksin, VV	1
Aston-Jones, G; Smith, RJ	1
Alp, HH; Keles, ON; Polat, B; Salman, AB; Suleyman, H; Yigiter, M; Yildiz, A	1
He, HM; Lu, HG; Ren, LM; Tian, HL; Zhao, D	1
Aglawe, MM; Chopde, CT; Kotagale, NR; Taksande, BG; Tripathi, SJ; Umekar, MJ	1
Gupta, S; Sharma, B	1
Kuzmenko, NV; Pliss, MG; Tsyrlin, VA	1

Reviews

9 review(s) available for clonidine and moxonidine

Article	Year
Clinical pharmacology of drugs acting on imidazoline and adrenergic receptors. Studies with clonidine, moxonidine, rilmenidine, and atenolol. Annals of the New York Academy of Sciences, 1995, Jul-12, Volume: 763 Topics: Antihypertensive Agents; Atenolol; Clinical Trials as Topic; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Placebos; Receptors, Adrenergic; Receptors, Drug; Reference Values; Rilmenidine	1995
[Imidazole receptors and blood pressure regulation. High receptor selectivity of moxonidine]. Deutsche medizinische Wochenschrift (1946), 1993, Jun-25, Volume: 118, Issue:25 Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Humans; Hypertension; Imidazoles; Oxazoles; Rabbits; Rats; Receptors, Drug; Rilmenidine	1993
Aspects of tolerability of centrally acting antihypertensive drugs. Journal of cardiovascular pharmacology, 1996, Volume: 27 Suppl 3 Topics: Antihypertensive Agents; Clonidine; Humans; Imidazoles; Methyldopa; Reserpine; Substance Withdrawal Syndrome	1996
The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1997, Volume: 15, Issue:1 Topics: Animals; Antihypertensive Agents; Binding Sites; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Insulin Resistance; Obesity; Radioligand Assay; Rats; Receptors, Drug	1997
The imidazoline receptor in control of blood pressure by clonidine and allied drugs. The American journal of physiology, 1997, Volume: 273, Issue:5 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Humans; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Neurons; Oxazoles; Receptors, Drug; Rilmenidine	1997
[Clinical pharmacology of hypotensive drugs acting on central imidazoline receptors]. Polskie Archiwum Medycyny Wewnetrznej, 1998, Volume: 100, Issue:6 Topics: Antihypertensive Agents; Clonidine; Drug Interactions; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine	1998
Central I1-imidazoline receptors as targets of centrally acting antihypertensive drugs. Clinical pharmacology of moxonidine and rilmenidine. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Animals; Antihypertensive Agents; Brain; Clinical Trials as Topic; Clonidine; Hemodynamics; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine	1999
[Current views on migraine and anti-migraine preparations]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:10 Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Antidepressive Agents; Aza Compounds; Brain; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Clonidine; Fluoxetine; Humans; Imidazoles; Maprotiline; Methysergide; Migraine Disorders; Mutation; Pizotyline; Placebos; Propranolol; Research; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sympatholytics; Vasoconstrictor Agents	2003
Centrally acting antihypertensive agents: an update. Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:5 Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Oxazoles; Rilmenidine	2007

Trials

4 trial(s) available for clonidine and moxonidine

Article	Year
A comparison of the haemodynamic and behavioural effects of moxonidine and clonidine in normotensive subjects. British journal of clinical pharmacology, 1992, Volume: 33, Issue:3 Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Double-Blind Method; Heart Rate; Humans; Imidazoles; Male; Placebos; Psychomotor Performance	1992
Comparison of moxonidine and clonidine HCl in treating patients with hypertension. Journal of clinical pharmacology, 1987, Volume: 27, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Imidazoles; Male; Middle Aged; Pulse; Random Allocation	1987
Crossover comparison of moxonidine and clonidine in mild to moderate hypertension. European journal of clinical pharmacology, 1984, Volume: 27, Issue:2 Topics: Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clonidine; Creatine; Double-Blind Method; Electrocardiography; Female; Humans; Hypertension; Imidazoles; Male; Middle Aged; Pulse; Substance Withdrawal Syndrome	1984
Growth hormone secretion in response to the new centrally acting antihypertensive agent moxonidine in normal human subjects: comparison to clonidine and GHRH. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1995, Volume: 103, Issue:3 Topics: Administration, Oral; Adult; Antihypertensive Agents; Clonidine; Double-Blind Method; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Imidazoles; Injections, Intravenous; Male; Time Factors	1995

Other Studies

82 other study(ies) available for clonidine and moxonidine

Article	Year
Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. Journal of medicinal chemistry, 1996, Mar-15, Volume: 39, Issue:6 Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Blood Pressure; Bridged Bicyclo Compounds; CHO Cells; Cricetinae; Heptanes; Humans; Imidazoline Receptors; Macaca fascicularis; Rats; Receptors, Drug	1996
Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives. Journal of medicinal chemistry, 2003, May-08, Volume: 46, Issue:10 Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cattle; Frontal Lobe; Heart Rate; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kidney; Oxazines; Rabbits; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship	2003
Molecular basis of inverse agonism in a G protein-coupled receptor. Nature chemical biology, 2005, Volume: 1, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Ligands; Protein Binding; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Signal Transduction	2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
QSAR study of imidazoline antihypertensive drugs. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome. Journal of medicinal chemistry, 2015, Jan-22, Volume: 58, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Drug Discovery; Heart Rate; Imidazoline Receptors; Ligands; Metabolic Syndrome; Pyrrolidines; Rats; Rats, Wistar; Structure-Activity Relationship; Sympatholytics	2015
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. Bioorganic & medicinal chemistry, 2016, 07-15, Volume: 24, Issue:14 Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine	2016
Central presynaptic alpha 2-autoreceptors are involved in the blood pressure-lowering effect of moxonidine. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:1 Topics: Anesthesia; Animals; Antihypertensive Agents; Cerebral Cortex; Cisterna Magna; Clonidine; Hydroxydopamines; Imidazoles; In Vitro Techniques; Injections; Male; Muscle, Smooth; Neurons; Norepinephrine; Oxidopamine; Pulmonary Artery; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vas Deferens	1990
Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and alpha 2-adrenoceptor agonists in anaesthetized cats. British journal of pharmacology, 1989, Volume: 98, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Anesthesia; Animals; Cats; Clonidine; Hemodynamics; Imidazoles; Male; Piperazines; Receptors, Serotonin; Sympathetic Nervous System; Tetrahydronaphthalenes	1989
Unique presynaptic alpha 2-receptor selectivity and specificity of the antihypertensive agent moxonidine. Arzneimittel-Forschung, 1988, Volume: 38, Issue:10 Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Cerebral Cortex; Chemical Phenomena; Chemistry; Clonidine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Atria; Heart Rate; Imidazoles; Ligands; Male; Norepinephrine; Papillary Muscles; Phenylephrine; Prazosin; Pulmonary Artery; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Venae Cavae; Yohimbine	1988
General pharmacology of the novel centrally acting antihypertensive agent moxonidine. Arzneimittel-Forschung, 1988, Volume: 38, Issue:10 Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Cats; Chemical Phenomena; Chemistry; Clonidine; Disease Models, Animal; Diuresis; Dogs; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Heart Rate; Hypertension; Imidazoles; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; Motor Activity; Norepinephrine; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Salivation	1988
Identification, localization and functional analysis of imidazoline and alpha adrenergic receptors in canine prostate. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2 Topics: Animals; Autoradiography; Azepines; Binding Sites; Clonidine; Dogs; Guanylyl Imidodiphosphate; Imidazoles; Imidazoline Receptors; Male; Prostate; Prostatic Hyperplasia; Receptors, Adrenergic, alpha; Receptors, Drug	1994
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla. Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 1 Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Binding, Competitive; Blood Gas Analysis; Blood Pressure; Blood Pressure Determination; Cattle; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Medulla Oblongata; Microinjections; Radioligand Assay; Rats; Rats, Inbred SHR; Receptors, Drug	1994
Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow. Journal of cardiovascular pharmacology, 1994, Volume: 24 Suppl 1 Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Catecholamines; Clonidine; Disease Models, Animal; Heart; Heart Rate; Hypertension; Imidazoles; Isoproterenol; Lipid Peroxidation; Male; Malondialdehyde; Myocardium; Oxidation-Reduction; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Sarcolemma; Sarcoplasmic Reticulum; Vitamin E	1994
Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. British journal of pharmacology, 1995, Volume: 114, Issue:4 Topics: Analysis of Variance; Animals; Antihypertensive Agents; Clonidine; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Male; Pepsin A; Pylorus; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Stomach Ulcer	1995
A novel mechanism of action for hypertension control: moxonidine as a selective I1-imidazoline agonist. Cardiovascular drugs and therapy, 1994, Volume: 8 Suppl 1 Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Autoradiography; Binding Sites; Blood Pressure; Cattle; Cells, Cultured; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine	1994
Alpha 2-adrenergic, but not imidazole, agonists activate NaCl cotransport in rabbit tracheal epithelial cells. The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 1 Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Carrier Proteins; Cells, Cultured; Chloride-Bicarbonate Antiporters; Clonidine; Colforsin; Cyclic AMP; Drug Interactions; Epithelial Cells; Epithelium; Guanabenz; Imidazoles; Imidazoline Receptors; Iodine Radioisotopes; Isoproterenol; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Second Messenger Systems; Sodium Chloride Symporters; Symporters; Thromboxane-A Synthase; Trachea	1993
Effects of imidazolines on noradrenaline release in rat isolated kidney. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:2 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Electric Stimulation; Imidazoles; In Vitro Techniques; Isoindoles; Kidney; Male; Nordefrin; Norepinephrine; Rats; Rats, Wistar; Stimulation, Chemical; Sympathetic Nervous System; Yohimbine	1994
Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1 Topics: Adrenal Medulla; Affinity Labels; Animals; Antihypertensive Agents; Binding, Competitive; Cattle; Clonidine; Imidazoles; Imidazoline Receptors; Iodine Radioisotopes; Kidney; Kinetics; Medulla Oblongata; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug	1993
Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine	1996
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine. Journal of hypertension, 1996, Volume: 14, Issue:7 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors	1996
Drug withdrawal and rebound hypertension: differential action of the central antihypertensive drugs moxonidine and clonidine. Cardiovascular drugs and therapy, 1996, Volume: 10 Suppl 1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Heart Rate; Hypertension; Imidazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Substance Withdrawal Syndrome; Telemetry	1996
Presynaptic imidazoline receptors and alpha 2-adrenoceptors in the human heart: discrimination by clonidine and moxonidine. Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:5 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Heart Atria; Humans; Imidazoles; In Vitro Techniques; Isoindoles; Male; Middle Aged; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine	1996
Inhibition of the natriuretic action of the imidazoline receptor agonist moxonidine by indometacin in the rat. Pharmacology, 1995, Volume: 51, Issue:6 Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Creatinine; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Imidazoles; Imidazoline Receptors; Indomethacin; Kidney; Male; Natriuresis; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Drug	1995
Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1997, Volume: 15, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Glucose; Clonidine; Fructose; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Receptors, Drug	1997
Central cardiovascular actions of agmatine, a putative clonidine-displacing substance, in conscious rabbits. Neurochemistry international, 1997, Volume: 30, Issue:1 Topics: Adrenergic alpha-Agonists; Agmatine; Animals; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug	1997
Effects of imidazolines on noradrenaline release in brain: an investigation into their relationship to imidazoline, alpha 2 and H3 receptors. Neurochemistry international, 1997, Volume: 30, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Brain; Cerebral Cortex; Clonidine; Electric Stimulation; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Medulla Oblongata; Norepinephrine; Perfusion; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Drug; Receptors, Histamine H3; Tritium	1997
Effects of moxonidine and clonidine on renal function and blood pressure in anesthetized rats. Clinical nephrology, 1997, Volume: 47, Issue:5 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Glomerular Filtration Rate; Idazoxan; Imidazoles; Kidney; Male; Plasma Volume; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium; Water-Electrolyte Balance; Yohimbine	1997
Renal and blood pressure effects of moxonidine and clonidine in spontaneously hypertensive rats. Clinical nephrology, 1997, Volume: 48, Issue:6 Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Aminoacridines; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Idazoxan; Imidazoles; Kidney; Male; Phenformin; Rats; Rats, Inbred SHR; Sodium; Urodynamics; Yohimbine	1997
Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats. Journal of the autonomic nervous system, 1998, Oct-15, Volume: 72, Issue:2-3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine	1998
Comparison of the baroreceptor-heart rate reflex effects of moxonidine, rilmenidine and clonidine in conscious rabbits. Journal of the autonomic nervous system, 1998, Oct-15, Volume: 72, Issue:2-3 Topics: Adrenergic alpha-Agonists; Algorithms; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Clonidine; Female; Heart Rate; Imidazoles; Injections, Intraventricular; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Vagus Nerve	1998
Influence of sino-aortic barodenervation on the cardiovascular effects of imidazoline-like drugs. Journal of the autonomic nervous system, 1998, Oct-15, Volume: 72, Issue:2-3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Clonidine; Denervation; Heart Rate; Imidazoles; Injections, Intravenous; Male; Motor Activity; Oxazoles; Pressoreceptors; Rats; Rats, Wistar; Rilmenidine; Sinus of Valsalva; Telemetry	1998
Effect of moxonidine on blood pressure and sympathetic tone in conscious spontaneously hypertensive rats. European journal of pharmacology, 1998, Nov-27, Volume: 362, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Heart Rate; Hypertension; Imidazoles; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Nerves; Sympathetic Nervous System; Time Factors	1998
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice. British journal of pharmacology, 1999, Volume: 126, Issue:6 Topics: Adrenergic alpha-Antagonists; Amino Acid Substitution; Animals; Binding, Competitive; Blood Pressure; Cardiovascular Agents; Cell Line; Clonidine; Consciousness; Dogs; Heart Rate; Humans; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Mutation; Naphthyridines; Oxazoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Rilmenidine; Saphenous Vein; Tritium	1999
Effects of moxonidine and clonidine on potassium excretion in Sprague-Dawley rats. Pharmacological research, 1999, Volume: 39, Issue:5 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Interactions; Glomerular Filtration Rate; Imidazoles; Imidazoline Receptors; Male; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Drug; Renal Circulation	1999
Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Clonidine; Decerebrate State; Heart Rate; Imidazoles; Injections, Spinal; Medulla Oblongata; Microinjections; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine	1999
Central imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Microinjections; Models, Neurological; Norepinephrine; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Serotonin; Sympathetic Nervous System	1999
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Clonidine; Denervation; Heart Rate; Hypotension; Imidazoles; Male; Oxazoles; Pressoreceptors; Rats; Rats, Inbred SHR; Rilmenidine; Sinus of Valsalva; Time Factors	1999
Effects of imidazoline drugs on tyrosine and tryptophan hydroxylase activity in rat brain in vivo. Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881 Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Brain; Clonidine; Dihydroxyphenylalanine; Imidazoles; Male; Quinolines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase	1999
[New central agents in the treatment of arterial hypertension]. Anales de medicina interna (Madrid, Spain : 1984), 1999, Volume: 16, Issue:10 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Clonidine; Diabetes Complications; Humans; Hypertension; Imidazoles; Nifedipine; Oxazoles; Renin-Angiotensin System; Reserpine; Rilmenidine; Risk Factors; Sympathetic Nervous System; Vasodilator Agents	1999
Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Formaldehyde; Imidazoles; Imidazoline Receptors; Injections, Subcutaneous; Male; Pain; Pain Measurement; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug; Time Factors; Yohimbine	2000
Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. DNA and cell biology, 2000, Volume: 19, Issue:6 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; CHO Cells; Clonidine; Cloning, Molecular; COS Cells; Cricetinae; DNA, Complementary; Epinephrine; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Immune Sera; Iodine Radioisotopes; Molecular Sequence Data; Naphazoline; Receptors, Drug; Ruthenium Red; Sequence Tagged Sites; Staining and Labeling; Transfection; Yohimbine	2000
Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice. Anesthesiology, 2000, Volume: 93, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Drug Synergism; Hyperalgesia; Imidazoles; Male; Mice; Morphine; Peripheral Nerve Injuries	2000
Positive inotropic effects of imidazoline derivatives are not mediated via imidazoline binding sites but alpha1-adrenergic receptors. Japanese journal of pharmacology, 2000, Volume: 84, Issue:1 Topics: Agmatine; Animals; Binding, Competitive; Cardiotonic Agents; Clonidine; Heart; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Myocardial Contraction; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Drug	2000
Blockade by agmatine of catecholamine release from chromaffin cells is unrelated to imidazoline receptors. European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2 Topics: Acetylcholine; Agmatine; Animals; Benzofurans; Binding Sites; Binding, Competitive; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Imidazoline Receptors; Membrane Potentials; Potassium; Potassium Channels; Receptors, Drug; Receptors, Nicotinic; Sodium Channels	2001
Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Heart Rate; Imidazoles; Male; Microdialysis; Norepinephrine; Oxazoles; Prefrontal Cortex; Rats; Rats, Wistar; Rilmenidine; Sympathetic Nervous System	2001
The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK). Journal of neurochemistry, 2001, Volume: 79, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Cell Division; Clonidine; Enzyme Activation; Imidazoles; Imidazoline Receptors; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; PC12 Cells; Pheochromocytoma; Precipitin Tests; Protein Kinase C; Rats; Receptors, Drug; Tetradecanoylphorbol Acetate	2001
Pertussis toxin converts hyperpolarizations caused by alpha(2)-adrenoceptor agonists containing an imidazoline moiety into depolarizations in MIN 6 cells. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Cell Line; Clonidine; Epinephrine; Imidazoles; Insulin; Membrane Potentials; Mice; Oxymetazoline; Pertussis Toxin; Receptors, Adrenergic, alpha-2	2002
Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proceedings of the National Academy of Sciences of the United States of America, 2002, Sep-17, Volume: 99, Issue:19 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dexmedetomidine; Epinephrine; Heterozygote; Hypnotics and Sedatives; Imidazoles; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Receptors, Adrenergic, alpha-2	2002
Role of alpha 2-adrenoceptors and imidazoline receptors in the A5 region in the regulation of renal function in the rat. Proceedings of the Western Pharmacology Society, 2002, Volume: 45 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guanfacine; Heart Rate; Imidazoles; Imidazoline Receptors; Kidney; Male; Pons; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Sodium; Urodynamics	2002
Plasma catecholamines and chronic congestive heart failure. Circulation, 2002, Dec-17, Volume: 106, Issue:25 Topics: Adrenal Glands; Catecholamines; Chronic Disease; Clonidine; Diagnostic Techniques, Cardiovascular; Dopamine; Epinephrine; Heart Failure; Humans; Imidazoles; Imidazoline Receptors; Neural Inhibition; Neurotransmitter Agents; Norepinephrine; Predictive Value of Tests; Receptors, Drug; Sympathetic Nervous System; Sympatholytics	2002
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits. Journal of hypertension, 2003, Volume: 21, Issue:1 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine	2003
Dual effect of agmatine in the bisected rat vas deferens. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:3 Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Epididymis; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Potassium Chloride; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Yohimbine	2003
The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Disease Models, Animal; Female; Glucose; Glucose Tolerance Test; Hypertension; Imidazoles; Imidazoline Receptors; Male; Metabolic Syndrome; Obesity; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Time Factors	2003
Experimental approach to differentiation of the effects mediated by imidazole receptors and alpha2-adrenoceptors on platelets. Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:6 Topics: Adenosine Diphosphate; Adrenergic alpha-Agonists; Blood Platelets; Clonidine; Humans; Imidazoles; Ligands; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Adrenergic, alpha-2; Receptors, Drug	2003
Electrophysiological responses to imidazoline/alpha2-receptor agonists in rabbit sinoatrial node pacemaker cells. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:12 Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Agmatine; Animals; Antihypertensive Agents; Aorta, Thoracic; Clonidine; Imidazoles; Male; Rabbits; Sinoatrial Node; Vasoconstriction; Xylazine	2003
Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Function; Atrial Natriuretic Factor; Benzofurans; Blood Pressure; Cardiomegaly; Clonidine; Heart Atria; Hemodynamics; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; Yohimbine	2004
Urinary responses to acute moxonidine are inhibited by natriuretic peptide receptor antagonist. British journal of pharmacology, 2005, Volume: 145, Issue:1 Topics: Animals; Antihypertensive Agents; Benzofurans; Clonidine; Cyclic GMP; Diuresis; Dose-Response Relationship, Drug; Female; Imidazoles; Imidazoline Receptors; Natriuresis; Natriuretic Peptides; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine	2005
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience, 2005, Volume: 132, Issue:4 Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Animals; Antihypertensive Agents; Blotting, Western; Bradycardia; Chromatography, High Pressure Liquid; Clonidine; Female; Hypotension; Imidazoles; Imidazoline Receptors; Imidazolines; Injections, Intraventricular; Male; Medulla Oblongata; Norepinephrine; Oxidopamine; Presynaptic Terminals; Rabbits; Receptors, Drug; Serotonin; Serotonin Agents	2005
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X. Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 372, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Cholesterol; Clonidine; Disease Models, Animal; Female; Guanabenz; Hyperlipidemias; Imidazoles; Imidazoline Receptors; Liver; Male; Metabolic Syndrome; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Triglycerides	2006
Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts. European journal of pharmacology, 2006, Jul-10, Volume: 541, Issue:1-2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Bridged Bicyclo Compounds; Brimonidine Tartrate; Clonidine; Coronary Circulation; Drug Synergism; Female; Heart; Heart Rate; Heptanes; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Myocardium; Perfusion; Phenoxybenzamine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine	2006
Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test. European journal of pharmacology, 2007, Jun-22, Volume: 565, Issue:1-3 Topics: Agmatine; Animals; Antazoline; Antidepressive Agents; Benzofurans; Clonidine; Female; Imidazoles; Imidazoline Receptors; Male; Mice; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Swimming	2007
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. Neurochemistry international, 2007, Volume: 51, Issue:8 Topics: Animals; Antihypertensive Agents; Binding, Competitive; Calcium Signaling; Clonidine; Down-Regulation; Humans; Hypotension; Imidazoles; Imidazoline Receptors; Ligands; Lysophospholipids; Neurons; PC12 Cells; Protein Isoforms; Radioligand Assay; Rats; Receptor Aggregation; Receptors, Lysosphingolipid; RNA Interference; Sphingosine; Transfection	2007
Comparative study of NMDA and AMPA/kainate receptors involved in cardiovascular inhibition produced by imidazoline-like drugs in anaesthetized rats. Experimental physiology, 2007, Volume: 92, Issue:5 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Heart Rate; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate	2007
Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in stroke-prone, spontaneously hypertensive rats. Acta pharmacologica Sinica, 2007, Volume: 28, Issue:10 Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Clonidine; Female; Folic Acid; Hematinics; Hypertension; Imidazoles; Random Allocation; Rats; Rats, Inbred SHR; Vitamin B 12	2007
Effects of spinal alpha(2)-adrenoceptor and I(1)-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Hindlimb; Imidazoles; Imidazoline Receptors; Male; Mice; Mice, Inbred Strains; Movement; Receptors, Adrenergic, alpha-2; Spinal Cord; Spinal Cord Injuries; Yohimbine	2008
Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein. European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Ear; Imidazoles; Male; Norepinephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Vasoconstrictor Agents; Veins; Yohimbine	2008
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine	2008
Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats. Autonomic neuroscience : basic & clinical, 2008, Dec-05, Volume: 143, Issue:1-2 Topics: Adrenergic alpha-Agonists; Agmatine; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Blood Vessels; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Imidazoles; Imidazoline Receptors; Imidazolines; Injections, Intravenous; Male; Methoxamine; Rats; Rats, Wistar; Sympathetic Nervous System; Vasomotor System	2008
Microvascular effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:3 Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Clonidine; Disease Models, Animal; Hypertension; Imidazoles; Male; Microcirculation; Microscopy, Video; Muscle, Skeletal; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rilmenidine; Skin; Time Factors	2010
Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. European journal of pharmacology, 2010, Jul-10, Volume: 637, Issue:1-3 Topics: Agmatine; Animals; Anti-Anxiety Agents; Anxiety; Arginine; Biguanides; Brain; Clonidine; Dose-Response Relationship, Drug; Eflornithine; Ethanol; Guanidines; Imidazoles; Imidazoline Receptors; Ligands; Maze Learning; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	2010
[Acute management at the rising of arterial pressure which is not menacing to a life]. Kardiologiia, 2011, Volume: 51, Issue:2 Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Captopril; Clonidine; Electrocardiography; Female; Follow-Up Studies; Humans; Hypertension; Imidazoles; Male; Nifedipine; Severity of Illness Index; Sympatholytics; Treatment Outcome	2011
α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking. Biological psychiatry, 2011, Oct-15, Volume: 70, Issue:8 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Cues; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Guanfacine; Imidazoles; Imidazoline Receptors; Isoquinolines; Male; Motor Activity; Naphthyridines; Prazosin; Propranolol; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration	2011
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats. Surgery today, 2012, Volume: 42, Issue:11 Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Biopsy, Needle; Clonidine; Dihydropyridines; Disease Models, Animal; Imidazoles; Immunohistochemistry; Kidney; Male; Random Allocation; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Ureteral Obstruction	2012
Effects of imidazolines on neurogenic contraction in isolated urinary bladder detrusor strips from rabbit. Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:2 Topics: Adenosine Triphosphate; Agmatine; Animals; Carbachol; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Imidazolines; In Vitro Techniques; Male; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Purinergic Agonists; Rabbits; Synaptic Transmission; Urinary Bladder; Urinary Bladder, Neurogenic	2012
Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test. Pharmacology, biochemistry, and behavior, 2013, Volume: 107 Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Benzofurans; Biguanides; Bupropion; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Guanidines; Idazoxan; Imidazoles; Immobility Response, Tonic; Injections, Intraventricular; Male; Mice; Motor Activity	2013
Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia. European journal of pharmacology, 2014, Jan-15, Volume: 723 Topics: Acetylcholinesterase; Adrenergic alpha-2 Receptor Agonists; Animals; Brain; Brain Ischemia; Catalase; Clonidine; Dementia, Vascular; Glutathione; Imidazoles; Imidazoline Receptors; Learning Disabilities; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Receptors, Adrenergic, alpha-2; Superoxide Dismutase	2014
[ADRENERGIC AND IMIDAZOLINE MECHANISMS OF CIRCULATION CENTRAL REGULATION IN RATS OF DIFFERENT LINES]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2016, Volume: 102, Issue:4 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Baroreflex; Benzofurans; Blood Pressure; Brain; Clonidine; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Sympathetic Nervous System; Yohimbine	2016
INN Common stem: -onidine. Prescrire international, 2017, Volume: 26, Issue:181 Topics: Adrenergic alpha-2 Receptor Agonists; Antimalarials; Brimonidine Tartrate; Cinchona Alkaloids; Clonidine; Humans; Hypertension; Imidazoles; Ocular Hypertension; Rilmenidine; Rosacea; Terminology as Topic	2017