clonidine and methadone

clonidine has been researched along with methadone in 172 studies

Research

Studies (172)

Timeframe	Studies, this research(%)	All Research%
pre-1990	68 (39.53)	18.7374
1990's	37 (21.51)	18.2507
2000's	33 (19.19)	29.6817
2010's	29 (16.86)	24.3611
2020's	5 (2.91)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Canevari, A; Cugurra, F; Piredda, F	1
Gold, MS; Kleber, HD; Redmond, DE	3
Gold, MS; Kleber, HD; Pottash, AL; Sweeney, DR	3
Rawson, RA; Resnick, RB; Washton, AM	1
Lawrence, F; Rappolt, RT	1
Gold, MS; Kleber, HD; Pottash, AL; Redmond, DE; Sweeney, DR	1
Annexton, M	1
Dennison, SJ	2
Holdcroft, A; Nicol, ME	1
Attenburrow, MJ; Robson, P; Silverstone, PH	1
Jiang, Z	1
Camí, J; de la Torre, R; Gilabert, M; San, L	1
Lauzon, P	2
Bautista, L; Diéguez, A; Sopelana, P	1
Muga, R; Tor, J	1
Camí, J; Mata, R; Peri, JM; Porta, M; San, L	2
Olle, JM; Peri, JM; San, L; Torrens, M	1
Bradley, B; Gossop, M; Griffiths, P; Kasvikis, Y; Marks, I	1
Caballero, L; Iruela, LM; Oliveros, SC	1
Fraser, AD	1
Bigelow, GE; Liebson, IA; Preston, KL	2
De Marinis, M; Janiri, L; Mannelli, P; Tempesta, E	1
Cook, CC	1
Fram, DH; Holden, R; Marmo, J	1
Peachey, JE	1
Gossop, M	1
Cerri, C; Cocco, E; Rovati, L	1
Bond, WS	1
Agren, H	1
Laqueille, X; Loo, H	1
Cirera, E; García-Esteve, L; García-Giralt, M; Treserra, J; Vilalta, J	1
Charney, DS; Heninger, GR; Kleber, HD	1
Kleber, H; Kosten, T; Rounsaville, BJ	1
Freitas, PM	1
Kleber, HD; Kosten, TR; Rounsaville, BJ	1
Charney, D; Gaspari, J; Hogan, I; Kleber, HD; Kosten, T; O'Connor, C; Riordan, CE; Rounsaville, B	1
Levadi, DI	1
Camí, J; de Torres, S; Guerra, D; San, L; Solé, A; Ugena, B	1
Dorizzi, R; Lafisca, S; Marigo, M; Maschio, S; Tagliaro, F	1
Rawson, RA; Resnick, RB; Tennant, FS; Washton, AM	2
Extein, I; Gold, MS; Kleber, HD; Pottash, AL	2
Resnick, RB; Washton, AM	7
Gold, MS; Kleber, HD; Pottash, AC	1
Cerdeño Impuesto, V	1
Jeziorski, K; Matsumoto, H	1
Gold, MS; Kleber, HD	1
Krystal, JH; Redmond, DE	1
Geyer, G; Resnick, RB; Washton, AM	1
Dackis, CA; Gold, MS	1
Schloemer, NF; Skidmore, JW	1
Caruso, KA; Cohen, DJ; Ehrenkranz, RA; Hoder, EL; Kleber, HD; Leckman, JF; Poulsen, J	1
Blandina, P; Botti, P; Caramelli, L; Fantozzi, R; Ledda, F; Mannaioni, PF; Masini, E; Moroni, F; Peruzzi, S; Zorn, AM	2
Annitto, W; Dackis, CA; Gold, MS; Pottash, AL	1
Allison, F; Allison, W; Bourgeois, M; Daubech, JF; Daulouede, JP; de Saint-Affrique, H; Meggle, D; Tignol, J	1
Keup, W	1
Garwood, J; Perzel, JF; Resnick, RB; Washton, AM	1
Annitto, WJ; Extein, I; Gold, MS; Pottash, AC; Sweeney, DR	2
Johnson, MM	1
Gold, MS; Kleber, HD; Riordan, CE	1
Kleber, HD; Redmond, DE; Uhde, TW	1
Huey, LY; Janowsky, DS; Judd, LL; Parker, DC; Risch, SC; Segal, DS	1
Braverman, P; Charney, DS; Heninger, GR; Kleber, HD; Murburg, M; Redmond, DE; Riordan, CE; Sternberg, DE	1
Bukovinsky, MA; Digregorio, GJ	1
Charney, DS; Heninger, GR; Kleber, HD; Redmond, DE; Sternberg, DE	1
Yang, G	1
Janiri, L; Mannelli, P; Persico, AM; Serretti, A; Tempesta, E	1
Ghodse, H; Myles, J; Smith, SE	1
Bickel, WK; Higgins, ST; Hughes, JR	1
Cutler, R; Fishbain, DA; Rosomoff, HL	1
Gold, MS	1
Dawe, S; Gray, JA	1
Greenwood, J; Seivewright, NA	1
Bearn, J; Gossop, M; Strang, J	3
Kleber, HD	2
Connerney, I; Fischman, MW; Foltin, RW; Levin, FR	1
Ikizler, Y; Koren, G; Selby, P; Theis, JG	1
Brown, AS; Fleming, PM	1
Carnwath, T; Hardman, J	1
Dashe, JS; Jackson, GL; Olscher, DA; Wendel, GD; Zane, EH	1
Bertschy, G; Cucchia, AT; Ferrero, F; Monnat, M; Spagnoli, J	1
Gastpar, M; Kaube, H; Kienbaum, P; Klein, S; Peters, J; Scherbaum, N	1
Bammer, G; Bell, JR; Masterman, SC; Mattick, RP; Morris, A; Young, MR	1
Brooner, RK; Kidorf, MS; King, VL; Mirsky, AF; Stoller, KB	1
Bocchi, C; Delsignore, R; Fontanesi, B; Gerra, G; Rustichelli, P; Timpano, M; Zaimovic, A; Zambelli, U	1
Conte, G; De Risio, S; Pozzi, G	1
Bearn, J; Buntwal, N; Gossop, M; Strang, J	1
Bisaga, A; Popik, P; Radomska, M	1
Ali, RL; Farrell, M; Gowing, LR; White, JM	1
Alvarez, CE; Bascarán, MT; Bobes, J; Brewer, C; Carreño, JE; San Narciso, GI; Sánchez del Río, J	1
Allen, S; Farrell, M; Gupta, J; Howells, C; Marsden, J; Stillwell, G	1
Lan, S; Lu, H; Wang, G; Yuan, D; Zhan, C	1
Chaisson, RE; Hoover, DR; Leslie, JM; Preston, KL; Tucker, MJ; Umbricht, A	1
Bearn, J; Best, D; Beswick, T; Gossop, M; Rees, S; Strang, J	1
Aksel'rod, BA; Chichenkov, TO; Kubarev, DA; Savchenkov, VA; Sivolap, I	1
Schnoll, SH	1
Golden, SA; Sakhrani, DL	1
Drenger, B; Gozal, Y; Matot, I; Shauli, A; Weissman, C	1
Epstein, DH; Preston, KL; Schmittner, J; Schroeder, JR	1
Engerman, J; Fiscella, K; Meldrum, S; Moore, A	1
Berger, M; Billiard, M; Chalabreysse, M; Durst, P; Palazzolo, J; Peyrelong, JP; Vialle, A	1
Bearn, J; de Wet, CJ; Glasper, A; Gossop, M; Reed, LJ	1
Cubells, JF; Tang, YL; Zhao, C; Zhao, D	1
Bearn, J; Best, D; Beswick, T; Gossop, M; McCambridge, J; Rees, S; Strang, J	1
Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F	1
Daley, M; Fuller, BE; McCarty, D; Rieckmann, T; Thomas, CP	1
Bleiberg, J; Epstein, DH; Krantz, MJ; Preston, KL; Schmittner, J; Schroeder, JR	1
Farashbandi, H; Firoozabadi, A; Gorman, JM; Mowla, A	1
Chi, Y; Du, WJ; Guo, S; Jiang, ZN; Liu, ZQ; Luo, XN; Ren, YP; Sheng, LX; Smith, AK; Tang, YL; Xiao, L; Zhang, GF; Zhang, HX	1
Augener, S; Bachmann, HS; Bonnet, U; Lieb, B; Scherbaum, N; Siffert, W; Specka, M	1
Eid, NC; Epstein, DH; Krantz, MJ; Preston, KL; Schmittner, J; Schroeder, JR	1
Agthe, AG; Chavez-Valdez, R; Gauda, EB; Hendrix, CW; Jansson, L; Kim, GR; Lewis, TR; Mathias, KB; Yaster, M	1
Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T	1
Meader, N	1
Bramness, J; Gossop, M; Lobmaier, P; Waal, H	1
Day, E; Strang, J	1
Bio, LL; Poon, CY; Siu, A	1
Ewan, EE; Martin, TJ	1
da Silva, PS; Passos, RM; Waisberg, DR	1
Gorelick, DA; Mannelli, P; Patkar, AA; Peindl, K; Wu, LT	1
Bisaga, A; Kosten, T; Nunes, EV; O'Connor, PG; Sigmon, SC; Woody, G	1
Law, F; Melichar, J; O'Shea, J; Praveen, KT	1
Lopez Gonzales, K; Scherbaum, N; Specka, M	1
Bagley, SM; Brogly, SB; Holland, E; Wachman, EM	1
Ali, R; Farrell, M; Gowing, L; White, JM	1
Mohs, AJ; Peace, MR; Poklis, A; Poklis, JL; Wolf, CE	1
McPherson, C	1
Ayanga, D; Kosten, TR; Shorter, D	1
Ali, R; Gowing, L; Mbewe, D; White, JM	1
Coulton, S; Diaper, AM; Law, FD; Melichar, JK; Myles, JS; Nutt, DJ	1
Schiff, DM; Silverstein, M; Wachman, EM	1
Amato, L; Amin-Esmaeili, M; Gholami, J; Hoseinie, L; Rahimi-Movaghar, A; Yousefi-Nooraie, R	1
Davies, TH; Hansen, Z; Loudin, S; Murray, S; Nellhaus, EM	1
Barnett, BS; Suzuki, J; Ward, HB	1
Jones, HE; Kraft, WK	1
Ghazanfarpour, M; Keramat-Roudi, A; Mashhadi, ME; Mégarbane, B; Moghaddam, MMM; Najafi, MN; Rezaee, R; Roozbeh, N; Tsatsakis, A	1
Brusseau, C; Burnette, T; Heidel, RE	1
Davey, JG; Martin, J; Osborn, DA; Zankl, A	1
Manu, P; Rogozea, LM; Shulman, M	1
Acton, EK; Bilker, WB; Brensinger, CM; Dawwas, GK; Hennessy, S; Leonard, CE; Li, L; Miano, TA; Neuman, M; Nguyen, TPP; Soprano, SE; Wang, L; Woody, G; Yu, E	1
Maiti, R; Mishra, BR; Mohapatra, D; Padhan, M	1

Reviews

35 review(s) available for clonidine and methadone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Clonidine-naltrexone: a new technic for the detoxification of opiate addicts]. Medicina clinica, 1990, Nov-10, Volume: 95, Issue:16 Topics: Clonidine; Drug Therapy, Combination; Humans; Methadone; Naltrexone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	1990
Clinical toxicology of drugs used in the treatment of opiate dependency. Clinics in laboratory medicine, 1990, Volume: 10, Issue:2 Topics: Buprenorphine; Clonidine; Humans; Methadone; Methadyl Acetate; Naltrexone; Opioid-Related Disorders	1990
Clonidine and the treatment of the opiate withdrawal syndrome. Drug and alcohol dependence, 1988, Volume: 21, Issue:3 Topics: Clonidine; Humans; Hypotension; Methadone; Naltrexone; Narcotics; Substance Withdrawal Syndrome	1988
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327 Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome	1986
Narcotic withdrawal in the emergency department. The American journal of emergency medicine, 1985, Volume: 3, Issue:5 Topics: Clonidine; Emergency Service, Hospital; Endorphins; Humans; Methadone; Narcotics; Nervous System Diseases; Opioid-Related Disorders; Outpatients; Phenothiazines; Psychotropic Drugs; Substance Withdrawal Syndrome; Vomiting	1985
[Narcotic withdrawal syndrome. Therapeutic methods]. Revista clinica espanola, 1982, Oct-15, Volume: 167, Issue:1 Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesia; Brain; Central Nervous System Agents; Clonidine; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders	1982
[Treatment of opiate withdrawal syndromes (historical review)]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1984, Oct-22, Volume: 39, Issue:43 Topics: Antipsychotic Agents; Clonidine; Drug Evaluation; History, 19th Century; History, 20th Century; Humans; Methadone; Methadyl Acetate; Morphine; Narcotic Antagonists; Phenothiazines; Substance Withdrawal Syndrome	1984
Multiple mechanisms of withdrawal from opioid drugs. Annual review of neuroscience, 1984, Volume: 7 Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Conditioning, Psychological; Cyclic GMP; Dopamine; Drug Tolerance; Enkephalins; Fear; gamma-Aminobutyric Acid; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Norepinephrine; Protein Conformation; Receptors, Opioid; Serotonin; Substance Withdrawal Syndrome	1984
New insights and treatments: opiate withdrawal and cocaine addiction. Clinical therapeutics, 1984, Volume: 7, Issue:1 Topics: Brain Chemistry; Clonidine; Cocaine; Dopamine; Humans; Methadone; Naltrexone; Norepinephrine; Substance Withdrawal Syndrome; Substance-Related Disorders	1984
Common errors in the pharmacologic treatment of drug dependence and withdrawal. Comprehensive therapy, 1994, Volume: 20, Issue:2 Topics: Behavior Therapy; Buprenorphine; Clonidine; Humans; Lithium; Methadone; Narcotics; Nicotine; Psychotherapy; Substance Withdrawal Syndrome; Thiamine	1994
Opiate detoxification protocols. A clinical manual. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 1993, Volume: 5, Issue:1 Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Psychiatric Status Rating Scales; Receptors, Opioid; Substance Withdrawal Syndrome	1993
Opiate addiction and the locus coeruleus. The clinical utility of clonidine, naltrexone, methadone, and buprenorphine. The Psychiatric clinics of North America, 1993, Volume: 16, Issue:1 Topics: Animals; Buprenorphine; Clonidine; Humans; Locus Coeruleus; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1993
What is important in drug misuse treatment? Lancet (London, England), 1996, Feb-10, Volume: 347, Issue:8998 Topics: Buprenorphine; Clonidine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Substance-Related Disorders; United Kingdom	1996
Current management of the neonatal abstinence syndrome: a critical analysis of the evidence. Biology of the neonate, 1997, Volume: 71, Issue:6 Topics: Analgesics, Opioid; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Clonidine; Diazepam; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; MEDLINE; Methadone; Morphine; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; Phenobarbital; Sympatholytics	1997
Lofexidine for opiate detoxification: review of recent randomised and open controlled trials. The American journal on addictions, 1999,Fall, Volume: 8, Issue:4 Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome	1999
[Contemporary methods in pharmacotherapy in the opiate dependent treatment]. Przeglad lekarski, 2000, Volume: 57, Issue:10 Topics: Adrenergic alpha-Agonists; Buprenorphine; Clonidine; Heroin Dependence; Humans; Inactivation, Metabolic; Methadone; Naltrexone; Narcotic Antagonists; Narcotics	2000
Alpha2-adrenergic agonists in opioid withdrawal. Addiction (Abingdon, England), 2002, Volume: 97, Issue:1 Topics: Adrenergic alpha-Agonists; Clonidine; Confidence Intervals; Controlled Clinical Trials as Topic; Humans; Methadone; Narcotics; Odds Ratio; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome	2002
Pharmacologic treatments for heroin and cocaine dependence. The American journal on addictions, 2003, Volume: 12, Issue:s2 Topics: Buprenorphine; Clonidine; Cocaine-Related Disorders; Comorbidity; Heroin Dependence; Humans; Mental Disorders; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Narcotics	2003
Opiate addiction in China: current situation and treatments. Addiction (Abingdon, England), 2006, Volume: 101, Issue:5 Topics: Buprenorphine; China; Clonidine; Drugs, Chinese Herbal; HIV Infections; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Sympatholytics	2006
A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis. Drug and alcohol dependence, 2010, Apr-01, Volume: 108, Issue:1-2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Buprenorphine; Clonidine; Data Interpretation, Statistical; Humans; Methadone; Narcotic Antagonists; Narcotics; Odds Ratio; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome	2010
The pharmacological treatment of opioid addiction--a clinical perspective. European journal of clinical pharmacology, 2010, Volume: 66, Issue:6 Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Social Support; Substance Withdrawal Syndrome	2010
Update on the pharmacologic management of neonatal abstinence syndrome. Journal of perinatology : official journal of the California Perinatal Association, 2011, Volume: 31, Issue:11 Topics: Benzodiazepines; Buprenorphine; Clonidine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy	2011
Opioid detoxification and naltrexone induction strategies: recommendations for clinical practice. The American journal of drug and alcohol abuse, 2012, Volume: 38, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clinical Protocols; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Substance Withdrawal Syndrome	2012
Review of the assessment and management of neonatal abstinence syndrome. Addiction science & clinical practice, 2014, Sep-09, Volume: 9, Issue:1 Topics: Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects	2014
Alpha₂-adrenergic agonists for the management of opioid withdrawal. The Cochrane database of systematic reviews, 2016, May-03, Issue:5 Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Clonidine; Controlled Clinical Trials as Topic; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	2016
Pharmacotherapy for Neonatal Abstinence Syndrome: Choosing the Right Opioid or No Opioid at All. Neonatal network : NN, 2016, Volume: 35, Issue:5 Topics: Analgesics; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Phenobarbital	2016
Update on pharmacotherapy for treatment of opioid use disorder. Expert opinion on pharmacotherapy, 2016, Volume: 17, Issue:17 Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Combined Modality Therapy; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome	2016
Buprenorphine for managing opioid withdrawal. The Cochrane database of systematic reviews, 2017, 02-21, Volume: 2 Topics: Acute Disease; Buprenorphine; Clonidine; Female; Humans; Male; Methadone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	2017
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment. JAMA, 2018, Apr-03, Volume: 319, Issue:13 Topics: Acupuncture Therapy; Analgesics; Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Morphine; Mothers; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Rooming-in Care	2018
Pharmacological therapies for management of opium withdrawal. The Cochrane database of systematic reviews, 2018, 06-21, Volume: 6 Topics: Amantadine; Amines; Baclofen; Buprenorphine; Clonidine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Methadone; Opioid-Related Disorders; Opium; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome; Tramadol	2018
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome. Clinics in perinatology, 2019, Volume: 46, Issue:2 Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breast Feeding; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Clonidine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Kangaroo-Mother Care Method; Maternal-Fetal Exchange; Methadone; Neonatal Abstinence Syndrome; Occupational Therapy; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Management; Patient Education as Topic; Phenobarbital; Physical Therapy Modalities; Pregnancy; Pregnancy Complications; Rooming-in Care	2019
Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2019, Volume: 27, Issue:1 Topics: Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Infant, Newborn; Length of Stay; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome	2019
Opioid treatment for opioid withdrawal in newborn infants. The Cochrane database of systematic reviews, 2021, 07-07, Volume: 7 Topics: Buprenorphine; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Opium; Phenobarbital; Randomized Controlled Trials as Topic	2021
Efficacy and safety of tramadol in the treatment of opioid withdrawal: A meta-analysis of randomized controlled trials. Addictive behaviors, 2023, Volume: 147 Topics: Bayes Theorem; Buprenorphine; Clonidine; Humans; Methadone; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome; Tramadol	2023

Trials

46 trial(s) available for clonidine and methadone

Article	Year
Clonidine blocks acute opiate-withdrawal symptoms. Lancet (London, England), 1978, Sep-16, Volume: 2, Issue:8090 Topics: Acute Disease; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Follow-Up Studies; Humans; Methadone; Nursing Assessment; Patient Compliance; Placebos; Self-Assessment; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors	1978
Noradrenergic hyperactivity in opiate withdrawal supported by clonidine reversal of opiate withdrawal. The American journal of psychiatry, 1979, Volume: 136, Issue:1 Topics: Clinical Trials as Topic; Clonidine; Double-Blind Method; Heroin Dependence; Humans; Locus Coeruleus; Male; Methadone; Norepinephrine; Substance Withdrawal Syndrome	1979
The calcium channel antagonist nifedipine causes confusion when used to treat opiate withdrawal in morphine-dependent patients. International clinical psychopharmacology, 1992, Volume: 7, Issue:2 Topics: Adult; Clonidine; Confusion; Double-Blind Method; Humans; Male; Methadone; Morphine Dependence; Nifedipine; Substance Withdrawal Syndrome	1992
Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts. British journal of addiction, 1992, Volume: 87, Issue:8 Topics: Adult; Circadian Rhythm; Clonidine; Double-Blind Method; Guanfacine; Heroin; Heroin Dependence; Humans; Hydrocortisone; Male; Methadone; Substance Withdrawal Syndrome	1992
Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial. British journal of addiction, 1990, Volume: 85, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Guanfacine; Guanidines; Heroin Dependence; Humans; Male; Methadone; Phenylacetates; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	1990
Cocaine abuse among heroin addicts in Spain. Drug and alcohol dependence, 1991, Volume: 27, Issue:1 Topics: Adolescent; Adult; Clonidine; Cocaine; Cross-Cultural Comparison; Cross-Sectional Studies; Female; Heroin Dependence; HIV Seroprevalence; Humans; Incidence; Male; Methadone; Personality Tests; Spain; Substance-Related Disorders	1991
Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Drug and alcohol dependence, 1989, Volume: 24, Issue:2 Topics: Anesthetics, Local; Antipsychotic Agents; Clonidine; Follow-Up Studies; Heroin Dependence; Humans; Methadone; Phenethylamines; Randomized Controlled Trials as Topic; Receptors, Opioid; Substance-Related Disorders	1989
Success and failure at inpatient heroin detoxification. British journal of addiction, 1989, Volume: 84, Issue:1 Topics: Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Guanfacine; Guanidines; Heroin Dependence; Humans; Male; Methadone; Phenylacetates; Psychiatric Department, Hospital; Random Allocation	1989
Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:2 Topics: Animals; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Ethanol; Humans; Mental Disorders; Methadone; Narcotic Antagonists; Narcotics; Panic; Schizophrenia; Substance Withdrawal Syndrome; Tobacco Use Disorder	1986
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327 Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome	1986
[Methadone, clonidine and levomepromazine in the treatment of opiate abstinence syndrome: double-blind clinical trial in heroin-addicted patients admitted to a general hospital for organic pathology]. Medicina clinica, 1987, May-02, Volume: 88, Issue:17 Topics: Clonidine; Double-Blind Method; Female; Heroin; Hospitalization; Hospitals, General; Humans; Male; Methadone; Methotrimeprazine; Random Allocation; Substance Withdrawal Syndrome	1987
Success and failure at outpatient opioid detoxification. Evaluating the process of clonidine- and methadone-assisted withdrawal. The Journal of nervous and mental disease, 1985, Volume: 173, Issue:2 Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Clonidine; Female; Follow-Up Studies; Humans; Male; Mental Disorders; Methadone; Middle Aged; Opioid-Related Disorders; Patient Compliance; Personality Inventory; Probability; Random Allocation; Substance Withdrawal Syndrome	1985
Comparison of clinician ratings to self reports of withdrawal during clonidine detoxification of opiate addicts. The American journal of drug and alcohol abuse, 1985, Volume: 11, Issue:1-2 Topics: Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Random Allocation; Self-Assessment; Substance Withdrawal Syndrome	1985
Clonidine in outpatient detoxification from methadone maintenance. Archives of general psychiatry, 1985, Volume: 42, Issue:4 Topics: Adult; Ambulatory Care; Clonidine; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Substance Withdrawal Syndrome	1985
Clonidine versus methadone for opiate detoxification. Lancet (London, England), 1980, Dec-13, Volume: 2, Issue:8207 Topics: Clinical Trials as Topic; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naltrexone; Opioid-Related Disorders	1980
Clinical utility of clonidine in opiate withdrawal: a study of 100 patients. Progress in clinical and biological research, 1981, Volume: 71 Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Humans; Methadone; Naloxone; Norepinephrine; Opioid-Related Disorders; Receptors, Adrenergic; Substance Withdrawal Syndrome	1981
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:9 Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Substance Withdrawal Syndrome	1983
[Withdrawal of drug addicts from opiates using Limoge-type electrotherapy. Evaluation of 400 treatments]. Annales medico-psychologiques, 1982, Volume: 140, Issue:5 Topics: Adolescent; Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Electric Stimulation Therapy; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders	1982
Clonidine vs. methadone for opiate detoxification: double-blind outpatient trials. NIDA research monograph, 1981, Volume: 34 Topics: Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Humans; Inactivation, Metabolic; Methadone; Middle Aged; Opium; Placebos	1981
The effect of methadone on the behavioral and neuroendocrine responses of manic patients. Psychiatry research, 1982, Volume: 7, Issue:2 Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Clonidine; Growth Hormone; Humans; Hydrocortisone; Male; Methadone; Middle Aged; Prolactin; Psychiatric Status Rating Scales; Psychotic Disorders	1982
Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy. Archives of general psychiatry, 1982, Volume: 39, Issue:11 Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1982
The clinical use of clonidine in abrupt withdrawal from methadone. Effects on blood pressure and specific signs and symptoms. Archives of general psychiatry, 1981, Volume: 38, Issue:11 Topics: Adult; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Male; Methadone; Substance Withdrawal Syndrome	1981
Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. Drug and alcohol dependence, 1994, Volume: 36, Issue:2 Topics: Adult; Analgesics, Opioid; Buprenorphine; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Neurologic Examination; Opioid-Related Disorders; Patient Admission; Phenethylamines; Substance Withdrawal Syndrome	1994
Clonidine is not a useful adjunct to methadone gradual detoxification in opioid addiction. The British journal of psychiatry : the journal of mental science, 1994, Volume: 165, Issue:3 Topics: Adolescent; Adult; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methadone; Middle Aged; Neurologic Examination; Opioid-Related Disorders	1994
Craving and drug reward: a comparison of methadone and clonidine in detoxifying opiate addicts. Drug and alcohol dependence, 1995, Volume: 39, Issue:3 Topics: Adrenergic alpha-Agonists; Behavior Therapy; Clonidine; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heroin Dependence; Humans; Male; Methadone; Motivation; Narcotics; Neurologic Examination; Reinforcement, Psychology; Substance Withdrawal Syndrome	1995
Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal. Drug and alcohol dependence, 1996, Dec-02, Volume: 43, Issue:1-2 Topics: Adolescent; Adult; Blood Pressure; Clonidine; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Neurologic Examination; Substance Abuse Detection; Substance Withdrawal Syndrome	1996
A protocol to switch high-dose, methadone-maintained subjects to buprenorphine. The American journal on addictions, 1997,Spring, Volume: 6, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anxiety; Buprenorphine; Clonidine; Cocaine; Drug Administration Schedule; Female; Humans; Inpatients; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Oxazepam; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Sympatholytics; Treatment Outcome	1997
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3 Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypotension; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Severity of Illness Index; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Treatment Outcome	1998
Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal. Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Care; Blood Pressure; Chi-Square Distribution; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome	1998
Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification. Pharmacopsychiatry, 1998, Volume: 31, Issue:6 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anesthesia; Clonidine; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	1998
A pilot study of naltrexone-accelerated detoxification in opioid dependence. The Medical journal of Australia, 1999, Jul-05, Volume: 171, Issue:1 Topics: Adolescent; Adult; Analgesics; Anti-Anxiety Agents; Clonidine; Conscious Sedation; Female; Flunitrazepam; Heroin; Heroin Dependence; Hormones; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Octreotide; Pilot Projects; Substance Withdrawal Syndrome; Time Factors	1999
Rapid opiate detoxication in outpatient treatment: relationship with naltrexone compliance. Journal of substance abuse treatment, 2000, Volume: 18, Issue:2 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; GABA Agents; Heroin Dependence; Humans; Inactivation, Metabolic; Ketoprofen; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxazepam; Patient Compliance; Substance Withdrawal Syndrome; Treatment Outcome	2000
Combined use of trazodone-naltrexone versus clonidine-naltrexone in rapid withdrawal from methadone treatment. A comparative inpatient study. Drug and alcohol dependence, 2000, Jun-01, Volume: 59, Issue:3 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analysis of Variance; Clonidine; Drug Therapy, Combination; Female; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Selective Serotonin Reuptake Inhibitors; Statistics, Nonparametric; Substance Withdrawal Syndrome; Trazodone	2000
Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification. Drug and alcohol dependence, 2000, May-01, Volume: 59, Issue:2 Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Neurologic Examination; Opioid-Related Disorders; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome	2000
24-Hour opiate detoxification and antagonist induction at home--the 'Asturian method': a report on 1368 procedures. Addiction biology, 2002, Volume: 7, Issue:2 Topics: Administration, Oral; Adult; Aftercare; Anti-Anxiety Agents; Benzodiazepines; Clonidine; Drug Implants; Female; Follow-Up Studies; Heroin Dependence; Home Care Services, Hospital-Based; Humans; Male; Methadone; Naltrexone; Octreotide; Opioid-Related Disorders; Patient Admission; Substance Withdrawal Syndrome; Time Factors	2002
Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone. Drug and alcohol dependence, 2002, Jul-01, Volume: 67, Issue:2 Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Prisons; Substance Withdrawal Syndrome	2002
Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection. Drug and alcohol dependence, 2003, Apr-01, Volume: 69, Issue:3 Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Buprenorphine; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Heroin Dependence; HIV Infections; Hospitalization; Humans; Injections, Intramuscular; Male; Methadone; Middle Aged; Narcotics; Pain Measurement; Receptors, Opioid; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Treatment Outcome	2003
Epidural clonidine, bupivacaine and methadone as the sole analgesic agent after thoracotomy for lung resection. Anaesthesia, 2004, Volume: 59, Issue:9 Topics: Adult; Aged; Analgesia, Epidural; Analgesics; Bupivacaine; Clonidine; Double-Blind Method; Female; Humans; Hypotension; Male; Methadone; Middle Aged; Pain Measurement; Postoperative Complications; Respiratory Mechanics; Spirometry; Thoracotomy	2004
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone. Drug and alcohol dependence, 2007, Apr-17, Volume: 88, Issue:1 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Treatment Outcome	2007
Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study. Pharmacotherapy, 2007, Volume: 27, Issue:8 Topics: Adolescent; Adult; Blood Pressure; Clonidine; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Narcotics; Pilot Projects; Prospective Studies; Substance Withdrawal Syndrome	2007
Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene. Progress in neuro-psychopharmacology & biological psychiatry, 2009, Jun-15, Volume: 33, Issue:4 Topics: Adult; Analgesics, Opioid; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Administration Schedule; Female; Genotype; Heterotrimeric GTP-Binding Proteins; Humans; Male; Methadone; Opioid-Related Disorders; Polymorphism, Genetic; Substance Withdrawal Syndrome; Time Factors; Young Adult	2009
Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study. Pharmacotherapy, 2009, Volume: 29, Issue:5 Topics: Adult; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Pilot Projects; Risk Factors; Sex Characteristics	2009
Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. Pediatrics, 2009, Volume: 123, Issue:5 Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Blood Pressure; Clonidine; Drug Therapy, Combination; Female; Heart Rate; Heroin; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstinence Syndrome; Opium; Prospective Studies; Treatment Outcome	2009
Outpatient versus inpatient opioid detoxification: a randomized controlled trial. Journal of substance abuse treatment, 2011, Volume: 40, Issue:1 Topics: Analgesics, Opioid; Clonidine; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadone; Narcotics; Opioid-Related Disorders; Outcome Assessment, Health Care; Outpatients; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome	2011
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal. The American journal of drug and alcohol abuse, 2012, Volume: 38, Issue:3 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Disease Management; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Substance Withdrawal Syndrome	2012
Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals. Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:8 Topics: Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Clonidine; Craving; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult	2017

Other Studies

92 other study(ies) available for clonidine and methadone

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
[Detoxication of heroin addicts in the area of Genoa]. La Clinica terapeutica, 1979, Dec-31, Volume: 91, Issue:6 Topics: Adolescent; Adult; Amino Acids; Clonidine; Diazepam; Female; Fructose; Heroin Dependence; Humans; Male; Methadone; ortho-Aminobenzoates; Substance Withdrawal Syndrome; Sulpiride; Vitamins	1979
Clonidine in opiate withdrawal. Lancet (London, England), 1978, Apr-29, Volume: 1, Issue:8070 Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders	1978
Clonidine detoxification: a fourteen-day protocol for rapid opiate withdrawal. NIDA research monograph, 1979, Volume: 27 Topics: Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Time Factors	1979
Clonidine hydrochloride: a nonopiate treatment for opiate withdrawal. NIDA research monograph, 1979, Volume: 27 Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1979
Outpatient detoxification of heroin addiction, 1969--1973 (methadone, darvon, codeine, clonidine). Clinical toxicology, 1979, Volume: 14, Issue:1 Topics: Clonidine; Codeine; Dextropropoxyphene; Heroin Dependence; Humans; Methadone	1979
Decreased serum prolactin in opiate withdrawal and dopaminergic hyperactivity. The American journal of psychiatry, 1979, Volume: 136, Issue:6 Topics: Clonidine; Humans; Methadone; Narcotics; Prolactin; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders	1979
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates. The American journal of psychiatry, 1979, Volume: 136, Issue:7 Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Methadone; Narcotics; Panic; Substance Withdrawal Syndrome; Substance-Related Disorders	1979
Clonidine may relieve opiate withdrawal symptoms. JAMA, 1978, Dec-01, Volume: 240, Issue:23 Topics: Clonidine; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders	1978
Mr R: a case study of withdrawal. Behavioral medicine (Washington, D.C.), 1992,Fall, Volume: 18, Issue:3 Topics: Alcoholism; Clonidine; Cocaine; Humans; Male; Methadone; Middle Aged; Neurologic Examination; Opioid-Related Disorders; Placebo Effect; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders	1992
Density of intrathecal agents. British journal of anaesthesia, 1992, Volume: 68, Issue:1 Topics: Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Baclofen; Body Temperature; Cerebrospinal Fluid; Clonidine; Droperidol; Humans; Methadone; Midazolam; Naloxone; Specific Gravity; Temperature	1992
[Iatrogenic addiction of pethidine: clinical feature and experience of detoxification]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1992, Volume: 25, Issue:2 Topics: Adult; Clonidine; Female; Humans; Iatrogenic Disease; Male; Meperidine; Methadone; Substance-Related Disorders	1992
Two cases of clonidine abuse/dependence in methadone-maintained patients. Journal of substance abuse treatment, 1992, Volume: 9, Issue:2 Topics: Clonidine; Dose-Response Relationship, Drug; Female; Heroin Dependence; HIV Seropositivity; Humans; Methadone; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Substance-Related Disorders	1992
Methadone maintenance and clonidine detoxification in the treatment of opiate addicts in Israel: suggesting evidence for cultural differences in the effectiveness of treatment modalities for opiate addiction. The Israel journal of psychiatry and related sciences, 1991, Volume: 28, Issue:3 Topics: Antidepressive Agents; Clonidine; Combined Modality Therapy; Cross-Cultural Comparison; Culture; Employment; Heroin Dependence; Israel; Longitudinal Studies; Methadone; Opioid-Related Disorders; Patient Dropouts; Psychotherapy; Recurrence; Substance Abuse Treatment Centers; United States	1991
[Factors affecting the course of hospital detoxication of drug addicts]. Medicina clinica, 1991, Sep-21, Volume: 97, Issue:9 Topics: Adult; Cannabis; Clonidine; Cocaine; Evaluation Studies as Topic; Female; Guanfacine; Heroin Dependence; Humans; Male; Mental Disorders; Methadone; Narcotics; Substance-Related Disorders	1991
[Drug addiction and detoxication units]. Medicina clinica, 1991, Sep-21, Volume: 97, Issue:9 Topics: Adult; Ambulatory Care; Clonidine; Female; Guanfacine; Heroin Dependence; Hospital Units; Humans; Male; Mental Disorders; Methadone; Prognosis; Spain; Substance-Related Disorders	1991
Clonidine versus long- and short-term methadone-aided withdrawal from opiates. An uncontrolled comparison. The International journal of the addictions, 1990, Volume: 25, Issue:10 Topics: Adult; Clonidine; Drug Administration Schedule; Female; Heroin; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Neuropsychological Tests; Substance Withdrawal Syndrome	1990
Self-administration of clonidine, oxazepam, and hydromorphone by patients undergoing methadone detoxification. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:2 Topics: Adult; Clonidine; Drug Administration Schedule; Humans; Hydromorphone; Male; Methadone; Opioid-Related Disorders; Oxazepam; Psychomotor Performance; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Surveys and Questionnaires	1985
Inpatient heroin detoxification: a comment. British journal of addiction, 1989, Volume: 84, Issue:11 Topics: Adrenergic alpha-Agonists; Clonidine; Follow-Up Studies; Guanfacine; Guanidines; Heroin Dependence; Humans; Methadone; Patient Dropouts; Phenylacetates	1989
Naltrexone treatment--the problem of patient acceptance. Journal of substance abuse treatment, 1989, Volume: 6, Issue:2 Topics: Adult; Clonidine; Female; Follow-Up Studies; Humans; Male; Methadone; Naltrexone; Opioid-Related Disorders; Patient Acceptance of Health Care	1989
The role of drugs in the treatment of opioid addicts. The Medical journal of Australia, 1986, Oct-20, Volume: 145, Issue:8 Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetics; Methadone; Mood Disorders; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders	1986
Propranolol and clonidine in detoxification. The American journal of psychiatry, 1988, Volume: 145, Issue:10 Topics: Clonidine; Humans; Lorazepam; Methadone; Opioid-Related Disorders; Propranolol; Psychomotor Agitation	1988
[Detoxication or physical weaning]. La Revue du praticien, 1987, May-21, Volume: 37, Issue:29 Topics: Clonidine; Depressive Disorder; Heroin Dependence; Humans; Methadone; Substance Withdrawal Syndrome	1987
The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone. The American journal of psychiatry, 1986, Volume: 143, Issue:7 Topics: Adult; Blood Pressure; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Methadone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders	1986
Use of guanabenz in methadone withdrawal. The American journal of psychiatry, 1985, Volume: 142, Issue:9 Topics: Adult; Clonidine; Female; Guanabenz; Guanidines; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1985
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin. Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3 Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Flunitrazepam; Heart Rate; Heroin; Humans; Inactivation, Metabolic; Male; Methadone; Substance-Related Disorders	1985
Calcitonin serum levels in heroin addicts: effects of methadone and clonidine detoxication treatments. Drug and alcohol dependence, 1985, Volume: 16, Issue:2 Topics: Adolescent; Adult; Calcitonin; Clonidine; Female; Heroin Dependence; Humans; Male; Methadone; Radioimmunoassay	1985
Clonidine hydrochloride detoxification from methadone treatment--the value of naltrexone aftercare. Advances in alcohol & substance abuse, 1984,Spring, Volume: 3, Issue:3 Topics: Adult; Aftercare; Attitude to Health; Clonidine; Female; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1984
Clonidine and opiate withdrawal. Lancet (London, England), 1980, Nov-15, Volume: 2, Issue:8203 Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1980
Outpatient clonidine detoxification. Lancet (London, England), 1981, Mar-14, Volume: 1, Issue:8220 Pt 1 Topics: Clonidine; Humans; Methadone; Outpatients; Patients; Substance Withdrawal Syndrome; Substance-Related Disorders	1981
Recent advances in opiate detoxification: clonidine and lofexidine. NIDA research monograph, 1983, Volume: 43 Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1983
Self-administration of clonidine and oxazepam by methadone detoxification patients. NIDA research monograph, 1984, Volume: 49 Topics: Adult; Clonidine; Humans; Male; Methadone; Opioid-Related Disorders; Oxazepam; Psychomotor Performance; Self Administration; Substance Withdrawal Syndrome	1984
Opiate withdrawal with clonidine. Journal of psychosocial nursing and mental health services, 1983, Volume: 21, Issue:10 Topics: Clonidine; Humans; Methadone; Nursing Assessment; Opioid-Related Disorders; Substance Withdrawal Syndrome	1983
Clonidine treatment of neonatal narcotic abstinence syndrome. Psychiatry research, 1984, Volume: 13, Issue:3 Topics: Administration, Oral; Clonidine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Methadone; Narcotics; Substance Withdrawal Syndrome	1984
Overall evaluation of treatment modalities for heroin addiction in a toxicology unit. Substance and alcohol actions/misuse, 1983, Volume: 4, Issue:4 Topics: Clonidine; Heroin Dependence; Hospital Units; Humans; Methadone; Morphine; Naloxone; Narcotics; Outcome and Process Assessment, Health Care; Patient Dropouts; Substance Withdrawal Syndrome	1983
The dexamethasone suppression test for major depression among opiate addicts. The American journal of psychiatry, 1984, Volume: 141, Issue:6 Topics: Adult; Clonidine; Depressive Disorder; Dexamethasone; Heroin Dependence; Humans; Hydrocortisone; Methadone; Opioid-Related Disorders; Substance-Related Disorders	1984
Clonidine hydrochloride detoxification from methadone treatments: the value of naltrexone aftercare. NIDA research monograph, 1981, Volume: 34 Topics: Adolescent; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Opium; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors	1981
Dopamine and serum prolactin in methadone withdrawal. NIDA research monograph, 1981, Volume: 34 Topics: Clonidine; Dopamine; Humans; Methadone; Prolactin; Substance Withdrawal Syndrome; Time Factors	1981
[Clonidine in opiate withdrawal. I. Principles of application (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1982, Feb-19, Volume: 124, Issue:7 Topics: Clonidine; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	1982
Opiate detoxification using lofexidine. NIDA research monograph, 1982, Volume: 41 Topics: Antihypertensive Agents; Clonidine; Humans; Male; Methadone; Opioid-Related Disorders	1982
Lofexidine blocks acute opiate withdrawal. NIDA research monograph, 1982, Volume: 41 Topics: Antihypertensive Agents; Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1982
Clonidine in opiate withdrawal. Journal of the National Medical Association, 1983, Volume: 75, Issue:2 Topics: Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1983
The use of clonidine in detoxification from opiates. Bulletin on narcotics, 1980, Volume: 32, Issue:2 Topics: Clonidine; Double-Blind Method; Humans; Methadone; Narcotics; Placebos; Substance Withdrawal Syndrome	1980
Clonidine suppresses the opioid abstinence syndrome without clonidine-withdrawal symptoms: a blind inpatient study. Psychiatry research, 1980, Volume: 2, Issue:1 Topics: Adult; Clonidine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1980
Outpatient opiate detoxification with clonidine. The Journal of clinical psychiatry, 1982, Volume: 43, Issue:6 Pt 2 Topics: Ambulatory Care; Clonidine; Double-Blind Method; Drug Therapy, Combination; Heroin Dependence; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1982
Lofexidine in abrupt methadone withdrawal. Psychopharmacology bulletin, 1982, Volume: 18, Issue:4 Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome	1982
[Medical aspects of opiate addiction]. Annali dell'Istituto superiore di sanita, 1982, Volume: 18, Issue:4 Topics: Clonidine; Heroin Dependence; Humans; Inpatients; Methadone; Naloxone; Risk	1982
Clonidine for narcotic withdrawal. American family physician, 1981, Volume: 24, Issue:3 Topics: Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1981
The clinical use of clonidine in outpatient detoxification from opiates. Progress in clinical and biological research, 1981, Volume: 71 Topics: Clonidine; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Self Administration; Substance Withdrawal Syndrome	1981
Opiate detoxification with lofexidine. Drug and alcohol dependence, 1981, Volume: 8, Issue:4 Topics: Clonidine; Humans; Methadone; Norepinephrine; Substance Withdrawal Syndrome; Time Factors	1981
Effect of methadone dosage on clonidine detoxification efficacy. The American journal of psychiatry, 1980, Volume: 137, Issue:3 Topics: Clonidine; Double-Blind Method; Humans; Male; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1980
Clonidine for opiate detoxification: outpatient clinical trials. The American journal of psychiatry, 1980, Volume: 137, Issue:9 Topics: Ambulatory Care; Clonidine; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1980
[Current status and prospectives of combating addiction of heroin]. Zhonghua yi xue za zhi, 1995, Volume: 75, Issue:3 Topics: Buprenorphine; Clonidine; Heroin Dependence; Humans; Methadone; Methadyl Acetate	1995
[Are substitution practices indicated in withdrawal within the framework of health care of drug addicts and according to what modalities?]. Annales de medecine interne, 1994, Volume: 145 Suppl 3 Topics: Clonidine; Heroin Dependence; Humans; Inpatients; Methadone; Outpatients; Prognosis; Quebec; Social Support; Therapeutic Community; Time Factors	1994
The Nathan B. Eddy Award Lecture: "A passion to improve treatment". NIDA research monograph, 1996, Volume: 162 Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Substance-Related Disorders	1996
A naturalistic study of home detoxification from opiates using lofexidine. Journal of psychopharmacology (Oxford, England), 1998, Volume: 12, Issue:1 Topics: Adult; Clonidine; Female; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Treatment Outcome	1998
Opioid detoxification in pregnancy. Obstetrics and gynecology, 1998, Volume: 92, Issue:5 Topics: Adult; Analgesics; Analgesics, Opioid; Chi-Square Distribution; Clonidine; Drug Therapy, Combination; Female; Humans; Inactivation, Metabolic; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome	1998
Ultra-rapid opiate detoxification using deep sedation with oral midazolam: short and long-term results. Drug and alcohol dependence, 1998, Nov-01, Volume: 52, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Anesthesia, General; Clonidine; Drug Therapy, Combination; Feasibility Studies; Female; Follow-Up Studies; Heroin Dependence; Humans; Hypnotics and Sedatives; Length of Stay; Male; Methadone; Midazolam; Naltrexone; Narcotic Antagonists; Neurologic Examination; Ondansetron; Substance Withdrawal Syndrome; Treatment Outcome	1998
Attention deficit hyperactivity disorder and treatment outcome in opioid abusers entering treatment. The Journal of nervous and mental disease, 1999, Volume: 187, Issue:8 Topics: Adult; Ambulatory Care; Attention; Attention Deficit Disorder with Hyperactivity; Clonidine; Cognition Disorders; Comorbidity; Counseling; Female; Humans; Male; Mental Disorders; Methadone; Neuropsychological Tests; Opioid-Related Disorders; Prognosis; Substance Abuse Treatment Centers; Treatment Outcome	1999
Clonidine abuse among opiate addicts. The Psychiatric quarterly, 2001,Summer, Volume: 72, Issue:2 Topics: Adult; Antihypertensive Agents; Clonidine; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotics; Substance-Related Disorders	2001
[Clinial study of "qingjunyin" detoxification for the treatment of heroin addicts]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 1997, Volume: 20, Issue:6 Topics: Adolescent; Adult; Clonidine; Drug Combinations; Drug Evaluation; Drugs, Chinese Herbal; Female; Heroin Dependence; Humans; Male; Methadone; Morphine; Phytotherapy	1997
Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments. Addiction biology, 2003, Volume: 8, Issue:1 Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Sleep Wake Disorders; Substance Withdrawal Syndrome; Time Factors	2003
[Detoxification in withdrawal state in methadone maintenance patients]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2003, Volume: 103, Issue:11 Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Data Interpretation, Statistical; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome	2003
The emperor' s new clothes. Journal of addictive diseases, 2003, Volume: 22, Issue:4 Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Clonidine; Heroin Dependence; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Retrospective Studies; Substance Withdrawal Syndrome; Tramadol	2003
Unexpected delirium during Rapid Opioid Detoxification (ROD). Journal of addictive diseases, 2004, Volume: 23, Issue:1 Topics: Adult; Alcohol Withdrawal Delirium; Clonidine; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Inactivation, Metabolic; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2004
QT interval increased after single dose of lofexidine. BMJ (Clinical research ed.), 2004, Nov-06, Volume: 329, Issue:7474 Topics: Adult; Clonidine; Female; Humans; Long QT Syndrome; Methadone; Narcotic Antagonists	2004
Management of opiate detoxification in jails. Journal of addictive diseases, 2005, Volume: 24, Issue:1 Topics: Acute Disease; Adrenergic alpha-Agonists; Clonidine; Health Care Surveys; Humans; Methadone; Narcotics; Opioid-Related Disorders; Prisoners; Substance Withdrawal Syndrome; United States	2005
[Methadone and sleep apnea syndrome]. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:3 Topics: Adult; Brain; Clonidine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Hydroxyzine; Methadone; Methotrimeprazine; Opioid-Related Disorders; Paroxetine; Polysomnography; Sleep Apnea, Central; Sleep Stages; Substance Withdrawal Syndrome; Trimeprazine	2005
Induction of patients with moderately severe methadone dependence onto buprenorphine. Addiction biology, 2005, Volume: 10, Issue:2 Topics: Adult; Buprenorphine; Clonidine; Drug Administration Schedule; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Severity of Illness Index; Surveys and Questionnaires	2005
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology, 2007, Volume: 106, Issue:2 Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroin; Hydromorphone; Infusions, Intravenous; Injections, Spinal; Male; Methadone; Morphine; Neuralgia; Pain; Rats; Rats, Inbred F344; Self Administration	2007
Client and counselor attitudes toward the use of medications for treatment of opioid dependence. Journal of substance abuse treatment, 2007, Volume: 32, Issue:2 Topics: Adult; Ambulatory Care; Attitude of Health Personnel; Buprenorphine; Clonidine; Counseling; Culture; Female; Focus Groups; Heroin Dependence; Humans; Ibogaine; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Patient Admission; Patient Satisfaction; Peer Group; Psychotropic Drugs; Substance Withdrawal Syndrome; Treatment Outcome	2007
Diphenoxylate hydrochloride dependency. Journal of psychiatric practice, 2007, Volume: 13, Issue:4 Topics: Adult; Antidiarrheals; Clonidine; Diphenoxylate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Iran; Male; Methadone; Narcotics; Opioid-Related Disorders; Psychotherapy; Substance Withdrawal Syndrome	2007
Dysfunction of the hypothalamic-pituitary-adrenal axis in opioid dependent subjects: effects of acute and protracted abstinence. The American journal of drug and alcohol abuse, 2008, Volume: 34, Issue:6 Topics: Adrenocorticotropic Hormone; Adult; Benzodiazepines; Clonidine; Corticotropin-Releasing Hormone; Female; Heroin Dependence; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Methadone; Pituitary-Adrenal System; Substance Withdrawal Syndrome; Young Adult	2008
Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate. Acta paediatrica (Oslo, Norway : 1992), 2010, Volume: 99, Issue:2 Topics: Blood Pressure; Chloral Hydrate; Clonidine; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Retrospective Studies; Treatment Outcome	2010
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids. Anesthesiology, 2011, Volume: 115, Issue:6 Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stimulation; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Hydromorphone; Injections, Spinal; Male; Methadone; Oxycodone; Peripheral Nerve Injuries; Rats; Rats, Inbred F344; Reward	2011
Withdrawal treatment with clonidine after prolonged use of chloral hydrate in a pediatric intensive care patient. Paediatric anaesthesia, 2011, Volume: 21, Issue:10 Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Chloral Hydrate; Clonidine; Fentanyl; Humans; Hypnotics and Sedatives; Infant; Intensive Care, Neonatal; Lorazepam; Male; Methadone; Midazolam; Pneumonia; Respiratory Insufficiency; Substance Withdrawal Syndrome	2011
Opioid dependence. American family physician, 2012, Sep-15, Volume: 86, Issue:6 Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prognosis; Risk Factors; Substance Withdrawal Syndrome; Time Factors	2012
[Outcomes of comprehensive inpatient opiate detoxification in patients re-admitted to treatment within one year]. Psychiatrische Praxis, 2015, Volume: 42, Issue:1 Topics: Adult; Aftercare; Clonidine; Comorbidity; Comprehensive Health Care; Female; Germany; Heroin Dependence; Humans; Male; Mental Disorders; Methadone; Middle Aged; Opiate Substitution Treatment; Patient Admission; Patient Dropouts; Patient Readmission; Recurrence; Treatment Outcome; Young Adult	2015
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS). Journal of analytical toxicology, 2016, Volume: 40, Issue:8 Topics: Amides; Analgesics; Anesthetics; Baclofen; Bupivacaine; Caffeine; Chromatography, High Pressure Liquid; Clonidine; Dexamethasone; Ephedrine; Fentanyl; Heparin; Hydromorphone; Ketamine; Mass Spectrometry; Methadone; Midazolam; Morphine; Oxytocin; Parenteral Nutrition Solutions; Phenylephrine; Ropivacaine; Succinylcholine	2016
Management of opioid withdrawal symptoms. The Medical letter on drugs and therapeutics, 2018, 08-27, Volume: 60, Issue:1554 Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2018
Expanded table: Some drugs for management of opioid withdrawal symptoms. The Medical letter on drugs and therapeutics, 2018, 08-27, Volume: 60, Issue:1554 Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2018
Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners, 2019, Volume: 33, Issue:1 Topics: Anticonvulsants; Clonidine; Female; Fentanyl; Humans; Infant, Newborn; Levetiracetam; Methadone; Myoclonus; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Parents; Pregnancy; Prenatal Exposure Delayed Effects; Treatment Outcome	2019
Rapid transition from methadone to buprenorphine using naltrexone-induced withdrawal: A case report. Substance abuse, 2019, Volume: 40, Issue:2 Topics: Adult; Antidiarrheals; Antiemetics; Antipruritics; Buprenorphine; Clonidine; Deprescriptions; Drug Substitution; Female; Humans; Loperamide; Methadone; Methocarbamol; Muscle Relaxants, Central; Naltrexone; Narcotic Antagonists; Ondansetron; Opiate Substitution Treatment; Opioid-Related Disorders; Promethazine; Substance Withdrawal Syndrome; Sympatholytics	2019
Clonidine versus phenobarbital as adjunctive therapy for neonatal abstinence syndrome. Journal of perinatology : official journal of the California Perinatal Association, 2020, Volume: 40, Issue:7 Topics: Analgesics, Opioid; Clonidine; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Prospective Studies	2020
Pharmacological Management of Heroin Withdrawal Syndrome: A Century of Expert Opinions in Cecil Textbook of Medicine. American journal of therapeutics, 2022, Feb-14, Volume: 29, Issue:2 Topics: Analgesics, Opioid; Buprenorphine; Clonidine; Expert Testimony; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2022
Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection. Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:5 Topics: Baclofen; Bayes Theorem; Benzodiazepines; Buprenorphine; Clonidine; Drug Interactions; Fluconazole; Humans; Methadone; Methocarbamol; Opiate Overdose; Opiate Substitution Treatment; Opioid-Related Disorders; Quetiapine Fumarate; Simvastatin	2022