clonidine and medetomidine

clonidine has been researched along with medetomidine in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.92)	18.7374
1990's	52 (85.25)	18.2507
2000's	5 (8.20)	29.6817
2010's	1 (1.64)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Saeki, S; Yaksh, TL	1
Dickenson, AH; Kalso, EA; McQuay, HJ; Sullivan, AF	1
Takano, M; Takano, Y; Yaksh, TL	1
Sperlágh, B; Vizi, ES	1
Kendig, JJ; Maze, M; Savola, MK; Woodley, SJ	1
Takano, Y; Yaksh, TL	2
Andersson, RG; Grundström, N; Jacobsson, L	1
Eddy, AC; Hill, HF; Kharasch, ED	1
Milne, B	1
Hartiala, J; Kallio, A; Saraste, M; Scheinin, H; Scheinin, M	1
Nagasaka, H; Yaksh, TL	1
Durcan, MJ; Linnoila, M; Lister, RG	1
Aslanian, V; Renaud, B	1
Nyman, L; Saano, V; Savola, JM; Virtanen, R	1
Dement, WC; Edgar, DM; Maze, M; Seidel, WF	1
Broadstone, RV; Manning, MM	1
Dalley, JW; Stanford, SC	1
Guo, TZ; Hayashi, Y; Maze, M	1
Chambers, JP; Livingston, A; Muge, DK	2
Maze, M; Salonen, M	1
Akerman, KE; Jansson, CC; Savola, JM	1
Ferrè, JP; Intorre, L; Maugeri, S; Soldani, G	1
Brenner, GM; Deason, LL; Klopp, AJ; Stevens, CW	1
De Kock, M; Meert, TF	2
Butelman, ER; Woods, JH	1
Bischoff, P; Kochs, E	1
Detweiler, DJ; Eisenach, JC; Jackson, C; Tong, C	1
Puke, MJ; Wiesenfeld-Hallin, Z	1
Hayashi, Y; Maze, M	1
Hämäläinen, MM; Pertovaara, A	1
Aantaa, R; Scheinin, M	1
Chen, MJ; Chiu, TH; Tang, FI; Yang, JJ; Yang, YR	1
Campion, DP; Leek, BF	1
Shen, H; Virag, L; Vulliemoz, Y	1
Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM	1
Boldt, J; Detsch, O; Dietrich, GV; Drevermann, J; Heesen, M; Hempelmann, G	1
Clarke, KW; England, GC	1
Brenner, GM; Stevens, CW	1
Dowlatshahi, P; Yaksh, TL	1
Ala-Kokko, TI; Hollmén, AI; Lampela, E; Pelkonen, O; Pienimäki, P; Vähäkangas, K	1
Asai, T; Mapleson, WW; Power, I	1
Aantaa, R; Kanto, JH; Kirvelä, OA; Taittonen, MT	1
Eisenach, JC; Klimscha, W; Tong, C	1
Bol, CJ; Danhof, M; IJzerman, AP; Mandema, JW	1
Hanin, I; Wülfert, E; Zhang, X	1
Mizobe, T	1
Graham, BA; Hammond, DL; Proudfit, HK	1
Buerkle, H; Yaksh, TL	1
Akamatsu, H; Maekawa, N; Mikawa, K; Nishina, K; Niwa, Y; Obara, H; Shiga, M	1
Black, WD; Celly, CS; McDonell, WN	1
Hébert, CA; Kudo, LH; Rouch, AJ	1
Dohi, S; Iida, H; Iida, M; Ohata, H; Watanabe, Y	1
Colpaert, FC; Pauwels, PJ	1
Alila-Johansson, A; Hätönen, T; Laakso, M; Mustanoja, SM	1
Arnebrant, T; Dahlström, M; Elwing, H; Holmberg, K; Jonsson, PR; Lausmaa, J; Mårtensson, LG; Sjögren, M	1
Bakshi, VP; Carasso, BS; Geyer, MA; Palomo, J; Powell, SB	1
Chen, W; Marvizón, JC; Song, B	1

Reviews

5 review(s) available for clonidine and medetomidine

Article	Year
[Alpha 2-agonists in anesthesia and intensive medicine]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1993, Volume: 28, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Clonidine; Critical Care; Epinephrine; GTP-Binding Proteins; Humans; Imidazoles; Medetomidine; Norepinephrine	1993
Alpha 2 adrenoceptor agonists and anaesthesia. British journal of anaesthesia, 1993, Volume: 71, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia, General; Anesthetics; Cardiovascular System; Central Nervous System; Clonidine; Humans; Imidazoles; Intraoperative Care; Medetomidine; Pain, Postoperative; Preanesthetic Medication	1993
Alpha 2-adrenergic agents in anaesthesia. Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:5 Topics: Analgesics; Anesthetics; Animals; Clonidine; Humans; Imidazoles; Medetomidine; Pentobarbital; Rabbits; Rats; Receptors, Adrenergic, alpha	1993
Alpha 2 adrenoceptor agonists in the horse--a review. The British veterinary journal, 1996, Volume: 152, Issue:6 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Horses; Hypnotics and Sedatives; Imidazoles; Medetomidine; Respiration; Xylazine	1996
[Adrenergic receptor and alpha 2 agonist--4: Applied and clinical pharmacology of alpha 2 agonist]. Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:8 Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Anesthetics; Animals; Clonidine; Humans; Hypnotics and Sedatives; Imidazoles; Medetomidine; Receptors, Adrenergic, alpha-2	1997

Trials

3 trial(s) available for clonidine and medetomidine

Article	Year
Acute hemodynamic effects of medetomidine and clonidine in healthy volunteers: a noninvasive echocardiographic study. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cardiac Output; Clonidine; Double-Blind Method; Echocardiography; Heart Rate; Hemodynamics; Humans; Imidazoles; Male; Medetomidine; Psychomotor Performance; Random Allocation; Vascular Resistance	1990
A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Dioxanes; Female; Humans; Idazoxan; Imidazoles; Injections, Spinal; Medetomidine; Receptors, Cholinergic; Sheep	1993
Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state. British journal of anaesthesia, 1997, Volume: 78, Issue:4 Topics: Adrenergic alpha-Agonists; Adult; Anesthesia, General; Clonidine; Double-Blind Method; Female; Hemodynamics; Humans; Imidazoles; Male; Medetomidine; Middle Aged; Oxygen Consumption; Premedication; Surgery, Plastic; Sympatholytics	1997

Other Studies

53 other study(ies) available for clonidine and medetomidine

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Suppression by spinal alpha-2 agonists of motor and autonomic responses evoked by low- and high-intensity thermal stimuli. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Heart Rate; Hot Temperature; Imidazoles; Male; Medetomidine; Prazosin; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Adrenergic, alpha; Reflex	1992
The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. European journal of pharmacology, 1992, Apr-29, Volume: 215, Issue:1 Topics: Action Potentials; Adrenergic alpha-Antagonists; Analgesics; Anesthesia; Animals; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Imidazoles; Male; Medetomidine; Naloxone; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord	1992
The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. European journal of pharmacology, 1992, Sep-04, Volume: 219, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Imidazoles; Injections, Spinal; Male; Medetomidine; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord	1992
Is the neuronal ATP release from guinea-pig vas deferens subject to alpha 2-adrenoceptor-mediated modulation? Neuroscience, 1992, Volume: 51, Issue:1 Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Berberine; Clonidine; Electric Stimulation; Guinea Pigs; Imidazoles; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Reserpine; Vas Deferens; Xylazine; Yohimbine	1992
Alpha 2-adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord. European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Animals; Animals, Newborn; Clonidine; Evoked Potentials; Imidazoles; In Vitro Techniques; Medetomidine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex, Monosynaptic; Spinal Cord	1991
Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible antagonist. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Injections, Spinal; Male; Medetomidine; Morphine; Quinolines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord	1991
Influence of some alpha 2-receptor agonists and antagonists on the excitatory non-adrenergic, non-cholinergic neurotransmission in the airways of guinea-pigs in vivo. Acta physiologica Scandinavica, 1991, Volume: 142, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; Guinea Pigs; Imidazoles; Male; Medetomidine; Quinoxalines; Respiratory Muscles; Respiratory System; Synaptic Transmission; Vagus Nerve	1991
Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism. Anesthesiology, 1991, Volume: 75, Issue:3 Topics: Adrenergic alpha-Agonists; Alfentanil; Biotransformation; Clonidine; Humans; Imidazoles; In Vitro Techniques; Medetomidine; Microsomes, Liver; Regression Analysis	1991
Alpha-2 agonists and anaesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1991, Volume: 38, Issue:7 Topics: Adrenergic alpha-Agonists; Clonidine; Humans; Imidazoles; Medetomidine; Preanesthetic Medication	1991
Pharmacology of intrathecal adrenergic agonists: cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesthesiology, 1990, Volume: 73, Issue:6 Topics: Adrenergic Agonists; Anesthesia, Inhalation; Animals; Clonidine; Halothane; Hemodynamics; Imidazoles; Injections, Spinal; Isoproterenol; Male; Medetomidine; Methoxamine; Nociceptors; Rats; Rats, Inbred Strains; Reflex	1990
Interactions of alpha 2-adrenoceptor antagonists with medetomidine and with ethanol in a holeboard test. Neuropharmacology, 1989, Volume: 28, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Ethanol; Idazoxan; Imidazoles; Male; Medetomidine; Mice	1989
Changes in serotonin metabolism in the rat raphe magnus and cardiovascular modifications following systemic administration of clonidine and other central alpha 2-agonists: an in vivo voltammetry study. Neuropharmacology, 1989, Volume: 28, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dioxanes; Electrochemistry; Heart Rate; Hemodynamics; Idazoxan; Imidazoles; Immunohistochemistry; Male; Medetomidine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin	1989
Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2 Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brain; Brimonidine Tartrate; Clonidine; Female; Imidazoles; In Vitro Techniques; Male; Medetomidine; Muscle, Smooth; Mydriatics; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens	1988
Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Motor Activity; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sleep; Sleep, REM	1995
Effects of alpha 2-adrenergic receptor agonist and antagonist drugs on cholinergic contraction in bovine tracheal smooth muscle in vitro. American journal of veterinary research, 1995, Volume: 56, Issue:7 Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Cattle; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; In Vitro Techniques; Medetomidine; Muscle Contraction; Muscle, Smooth; Receptors, Adrenergic, alpha-2; Tolazoline; Trachea	1995
Contrasting effects of the imidazol(in)e alpha 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies. British journal of pharmacology, 1995, Volume: 114, Issue:8 Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Frontal Lobe; Imidazoles; Male; Medetomidine; Microdialysis; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors	1995
Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Anesthesiology, 1995, Volume: 82, Issue:4 Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Binding Sites; Clonidine; Drug Tolerance; Hypnotics and Sedatives; Imidazoles; Locus Coeruleus; Male; Medetomidine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord	1995
Radioreceptor assay for determination of xylazine and medetomidine in sheep plasma. Journal of veterinary pharmacology and therapeutics, 1995, Volume: 18, Issue:1 Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Catecholamines; Cerebral Cortex; Clonidine; Female; Imidazoles; Isotope Labeling; Male; Medetomidine; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Reference Standards; Sheep; Spectrophotometry, Ultraviolet; Tritium; Xylazine	1995
Implementation of a radioreceptor assay for dexmedetomidine. Pharmacology & toxicology, 1993, Volume: 73, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Clonidine; Imidazoles; Male; Medetomidine; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha	1993
Different sensitivity of alpha 2A-C10 and alpha 2C-C4 receptor subtypes in coupling to inhibition of cAMP accumulation. Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2 Topics: Adenine; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Clonidine; Colforsin; Cyclic AMP; Fibroblasts; Humans; Imidazoles; Kinetics; Medetomidine; Norepinephrine; Receptors, Adrenergic, alpha-2; Tetradecanoylphorbol Acetate; Transfection; Yohimbine	1994
Effects of medetomidine on intestinal and colonic motility in the dog. Journal of veterinary pharmacology and therapeutics, 1994, Volume: 17, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Colon; Dogs; Drug Interactions; Electrophysiology; Gastrointestinal Motility; Hypnotics and Sedatives; Imidazoles; Injections, Intravenous; Jejunum; Medetomidine; Yohimbine	1994
Analgesic potency of alpha adrenergic agents after systemic administration in amphibians. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Imidazoles; Medetomidine; Norepinephrine; Rana pipiens	1994
Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats. Anesthesiology, 1994, Volume: 81, Issue:3 Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Drug Administration Routes; Drug Synergism; Fentanyl; Imidazoles; Male; Medetomidine; Narcotics; Pain Measurement; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2	1994
Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: spinal alpha 2 adrenoceptor subtypes and intrinsic activity. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1 Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Catheterization; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Imidazoles; Infusion Pumps, Implantable; Injections, Spinal; Medetomidine; Molecular Sequence Data; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord; Time Factors	1993
Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2 Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Azocines; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Rate; Hot Temperature; Idazoxan; Imidazoles; Macaca mulatta; Male; Medetomidine; Muscle Relaxation; Pain Threshold; Respiration; Xylazine	1993
The differential effects of morphine and the alpha 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesthesia and analgesia, 1993, Volume: 77, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Imidazoles; Male; Medetomidine; Morphine; Motor Activity; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Self Mutilation	1993
The rostroventromedial medulla is not involved in alpha 2-adrenoceptor-mediated antinociception in the rat. Neuropharmacology, 1993, Volume: 32, Issue:12 Topics: Analysis of Variance; Animals; Cerebellum; Clonidine; Dose-Response Relationship, Drug; Hot Temperature; Imidazoles; Lidocaine; Male; Medetomidine; Medulla Oblongata; Microinjections; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reflex; Skin Temperature; Spinal Cord; Time Factors	1993
Action of dexmedetomidine on rat locus coeruleus neurones: intracellular recording in vitro. European journal of pharmacology, 1995, Oct-24, Volume: 285, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Barium Compounds; Cesium; Chlorides; Clonidine; Electrophysiology; Imidazoles; In Vitro Techniques; Locus Coeruleus; Male; Medetomidine; Membrane Potentials; Neurons; Oxymetazoline; Parasympathetic Fibers, Postganglionic; Prazosin; Rats; Rats, Sprague-Dawley; Yohimbine	1995
The effects of intracoeliac injections of alpha-adrenergic agonists and veratridine on reticuloruminal motility and the evocation of rumination in sheep. Zentralblatt fur Veterinarmedizin. Reihe A, 1995, Volume: 42, Issue:7 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Gastrointestinal Motility; Imidazoles; Injections, Intra-Arterial; Medetomidine; Phenylephrine; Rumen; Sheep; Veratridine; Xylazine	1995
Single dose pharmacokinetics of medetomidine in sheep. Journal of veterinary pharmacology and therapeutics, 1996, Volume: 19, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Half-Life; Imidazoles; Injections, Intravenous; Isotope Labeling; Medetomidine; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sheep; Software; Tritium	1996
Alpha-2 adrenoceptor agonists decrease cyclic guanosine 3',5'-monophosphate in the mouse brain. Anesthesiology, 1996, Volume: 85, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brain Chemistry; Clonidine; Cyclic GMP; Imidazoles; Male; Medetomidine; Mice; NG-Nitroarginine Methyl Ester	1996
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein. Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine	1996
[The in vitro effect of alpha-2 agonists on thrombocyte function and density of thrombocyte alpha-2 receptors]. Der Anaesthesist, 1996, Volume: 45, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Blood Platelets; Clonidine; Humans; Imidazoles; In Vitro Techniques; Medetomidine; Phentolamine; Platelet Aggregation; Radioligand Assay; Receptors, Adrenergic, alpha-2; Yohimbine	1996
Spinal administration of adrenergic agents produces analgesia in amphibians. European journal of pharmacology, 1996, Dec-05, Volume: 316, Issue:2-3 Topics: Analgesics, Non-Narcotic; Animals; Clonidine; Epinephrine; Imidazoles; Injections, Spinal; Medetomidine; Norepinephrine; Pain; Rana esculenta	1996
Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesthesia and analgesia, 1997, Volume: 84, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Conscious Sedation; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Feeding Behavior; Imidazoles; Injections, Intraventricular; Male; Medetomidine; Methoxamine; Prazosin; Rats; Rats, Sprague-Dawley; Yohimbine	1997
Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta. Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:2 Topics: Adrenergic alpha-Agonists; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Antipyrine; Biological Transport; Clonidine; Female; Humans; Imidazoles; In Vitro Techniques; Maternal-Fetal Exchange; Medetomidine; Placenta; Pregnancy	1997
Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. British journal of anaesthesia, 1997, Volume: 78, Issue:3 Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Imidazoles; Male; Medetomidine; Morphine; Naloxone; Rats; Rats, Wistar; Yohimbine	1997
Intrathecal alpha 2-adrenergic agonists stimulate acetylcholine and norepinephrine release from the spinal cord dorsal horn in sheep. An in vivo microdialysis study. Anesthesiology, 1997, Volume: 87, Issue:1 Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Clonidine; Imidazoles; Injections, Spinal; Medetomidine; Microdialysis; Norepinephrine; Sheep; Spinal Cord	1997
Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:7 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Clonidine; Idazoxan; Imidazoles; Magnesium; Male; Manganese; Medetomidine; Membranes; Radioligand Assay; Rats; Reproducibility of Results; Retina; Sensitivity and Specificity; Tritium	1997
Mivazerol, a new alpha 2-adrenergic agonist, blunts cardiovascular effects following surgical stress in pentobarbital-anesthetized rats. Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:6 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Clonidine; Heart Rate; Imidazoles; Medetomidine; Pentobarbital; Rats; Rats, Sprague-Dawley; Stress, Physiological; Surgical Procedures, Operative; Yohimbine	1997
Alpha 2-adrenoceptor agonists and stress-induced analgesia in rats: influence of stressors and methods of analysis. Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesia; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Clonidine; Dose-Response Relationship, Drug; Handling, Psychological; Housing, Animal; Imidazoles; Immobilization; Male; Medetomidine; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Stress, Psychological; Xylazine	1997
Differences in the antinociceptive effects of alpha-2 adrenoceptor agonists in two substrains of Sprague-Dawley rats. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Injections, Spinal; Male; Medetomidine; Rats; Rats, Sprague-Dawley; Species Specificity; Spinal Cord	1997
Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat. British journal of anaesthesia, 1998, Volume: 81, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Analgesics, Non-Narcotic; Animals; Brimonidine Tartrate; Clonidine; Conscious Sedation; Hypnotics and Sedatives; Imidazoles; Injections, Intraventricular; Injections, Spinal; Male; Medetomidine; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine	1998
The effects of clonidine and dexmedetomidine on human neutrophil functions. Anesthesia and analgesia, 1999, Volume: 88, Issue:2 Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Calcium; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Clonidine; Free Radical Scavengers; Humans; Imidazoles; Infections; Medetomidine; Neutrophil Activation; Neutrophils; Phagocytosis; Reactive Oxygen Species; Superoxides; Xylazine	1999
Cardiopulmonary effects of the alpha2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anesthesia; Animals; Carbon Dioxide; Clonidine; Dose-Response Relationship, Drug; Female; Hemodynamics; Imidazoles; Medetomidine; Oxygen Consumption; Respiratory Mechanics; Sheep	1999
Inhibition of water permeability in the rat collecting duct: effect of imidazoline and alpha-2 compounds. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 221, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arginine Vasopressin; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Imidazoles; Kidney Tubules, Collecting; Medetomidine; Oxazoles; Oxymetazoline; Permeability; Rats; Rats, Wistar; Rilmenidine; Water	1999
Direct effects of alpha1- and alpha2-adrenergic agonists on spinal and cerebral pial vessels in dogs. Anesthesiology, 1999, Volume: 91, Issue:2 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Arterioles; Brain; Cerebrovascular Circulation; Clonidine; Dogs; Dose-Response Relationship, Drug; Epinephrine; Imidazoles; Medetomidine; Phenylephrine; Spinal Cord; Vasoconstriction	1999
Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions. British journal of pharmacology, 2000, Volume: 131, Issue:7 Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Calcium; CHO Cells; Clonidine; Cricetinae; DNA, Recombinant; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Idazoxan; Kinetics; Medetomidine; Mice; Oxymetazoline; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Transfection	2000
Evidence for central alpha(2)-adrenergic modulation of rat pineal melatonin synthesis. Brain research, 2000, Dec-22, Volume: 887, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Circadian Rhythm; Clonidine; Male; Medetomidine; Melatonin; Pineal Gland; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine	2000
Impact of polymer surface affinity of novel antifouling agents. Biotechnology and bioengineering, 2004, Apr-05, Volume: 86, Issue:1 Topics: Adsorption; Animals; Biocompatible Materials; Cell Adhesion; Clonidine; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Larva; Materials Testing; Medetomidine; Pest Control; Polystyrenes; Seawater; Surface Properties; Thoracica; Water	2004
Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Psychopharmacology, 2005, Volume: 180, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guanfacine; Imidazoles; Injections; Male; Medetomidine; Neural Inhibition; Piperazines; Prazosin; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-2; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Yohimbine	2005
Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors. Neuropharmacology, 2008, Volume: 54, Issue:6 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Brimonidine Tartrate; Clonidine; Data Interpretation, Statistical; Electric Stimulation; Enkephalins; Guanfacine; Immunohistochemistry; Male; Medetomidine; Microscopy, Confocal; Oligopeptides; Protease Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Veratridine	2008