clonidine has been researched along with idazoxan in 359 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 92 (25.63) | 18.7374 |
| 1990's | 198 (55.15) | 18.2507 |
| 2000's | 51 (14.21) | 29.6817 |
| 2010's | 18 (5.01) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, RC; Chapleo, CB; England, DC; Myers, PL; Roach, AG; Smith, CF; Stillings, MR; Tulloch, IF | 1 |
| England, CD; Smith, CF; Stillings, MR; Welbourn, AP | 1 |
| Haubrich, DR; Hlasta, DJ; Luttinger, D; Perrone, MH; Silbernagel, MJ; Ward, SJ | 1 |
| Butler, RC; Chapleo, CB; Doxey, JC; Myers, PL; Roach, AG; Smith, CF | 1 |
| Bondinell, W; Hieble, JP; Ruffolo, RR | 1 |
| Blitzer, RD; Cornfeldt, M; Davis, L; Effland, RC; Haroutunian, V; Huger, FP; Klein, JT; Landau, E; Martin, LL; Olsen, GE; Petko, WW; Smith, CP; Wilker, JC; Wong, GS | 1 |
| Arrault, A; Guillaumet, G; Mérour, JY; Pfeiffer, B; Renard, P; Rettori, MC; Scalbert, E; Touzeau, F | 1 |
| Callado, LF; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Callado, LF; Erdozain, AM; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 2 |
| Agbaba, D; Filipic, S; Nikolic, K | 1 |
| Callado, LF; Erdozain, AM; Goonan, A; Kahvedzić, A; McCabe, T; Meana, JJ; Nagle, PS; Rodriguez, F; Rozas, I | 1 |
| Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J | 1 |
| Beani, L; Bianchi, C; Guidorzi, R; Tomasini, C | 1 |
| Hjorth, S; Tao, R | 1 |
| Alburges, ME; Bylund, DB; Hunt, MA; Wamsley, JK | 1 |
| Enero, MA; Ricci, D; Taira, CA | 1 |
| Bonanno, G; Maura, G; Raiteri, M | 1 |
| García-Sevilla, JA; Pi, F | 1 |
| Fillenz, M; Vahabzadeh, A | 1 |
| Eisenach, JC; Limauro, D; Tong, C | 1 |
| Berridge, TL; Doxey, JC; Roach, AG; Smith, CF | 1 |
| Matsumoto, M; Saito, H; Smith, CB; Togashi, H; Yoshioka, M | 1 |
| Leidenheimer, NJ; Schechter, MD | 1 |
| Arnsten, AF; Contant, TA | 1 |
| Besson, JM; Guilbaud, G; Kayser, V | 1 |
| Hamilton, CA | 1 |
| Candura, SM; Coccini, T; Costa, LG; Manzo, L; Marraccini, P; Rossi, A; Tonini, M | 1 |
| Convents, A; De Backer, JP; De Keyser, J; De Vos, H; Vauquelin, G | 1 |
| Carratù, MR; De Serio, A; Mitolo-Chieppa, D; Navarra, P; Preziosi, P; Serio, M | 1 |
| Ger, LP; Tseng, CJ; Tung, CS | 1 |
| García-Barrado, MJ; Moratinos, J; Reverte, M | 2 |
| Bousquet, P; Feldman, J; Gonon, F; Mermet, C; Tibiriça, E | 1 |
| Guyenet, PG; Nosjean, A | 1 |
| Eisenach, JC; Tong, CY | 1 |
| Brasch, H | 1 |
| Cervo, L; Samanin, R | 1 |
| Boublik, JH; Brown, MR; Hua, XY; Rivier, JE; Spicer, MA; Yaksh, TL | 1 |
| Nicholson, AN; Pascoe, PA | 1 |
| Nicholson, T; Osman, TE | 1 |
| Horváth, E; Jaszlits, L; Rabloczky, G | 1 |
| Bourin, M; Bradwejn, J; Hascoët, M | 1 |
| Collewijn, H; Pompeiano, O; Tan, HS; van Neerven, J | 1 |
| Gunnet, JW; Ireland, LM; Lookingland, KJ; Manzanares, J; Moore, KE; Tian, Y | 1 |
| Marshall, IG; Prior, C; Wannan, G | 1 |
| Bousquet, P; Feldman, J; Gonon, F; Mermet, C; Monassier, L; Tibiriça, E | 1 |
| Ball, DM; Glue, P; Nutt, DJ; White, E; Wilson, S | 1 |
| Barthuel, P; Menini, C; Rektor, I; Silva-Barrat, C; Svejdová, M | 1 |
| Heistracher, M; Philippu, A; Prast, H | 1 |
| Meeley, MP; Regunathan, S; Reis, DJ | 1 |
| Hamahashi, T; Itoh, T; Kamisaki, Y; Okada, CM | 1 |
| Grealy, M; O'Donnell, JM | 1 |
| Hamilton, CA; Jardine, E; Reid, JL; Yakubu, MA | 1 |
| Fekete, MI; Szentendrei, T | 1 |
| Danzebrink, RM; Gebhart, GF | 1 |
| Chen, LS; McNamara, JO; Weingart, JB | 1 |
| Göthert, M; Molderings, GJ | 1 |
| Ferrari, RA; Hamel, LT; Haubrich, DR; Perrone, MH | 1 |
| Assenmacher, I; Barbanel, G; Gaillet, S; Malaval, F; Szafarczyk, A | 1 |
| Atlas, D; Diamant, S; Zonnenchein, R | 1 |
| Dresse, A; Giesbers, I; Massotte, L; Scuvée-Moreau, J; Seutin, V | 1 |
| Andrioli, GC; Cavazzani, P; Folghera, S; Göthert, M; Maura, G; Raiteri, M; Schalnus, R; Schlicker, E | 1 |
| Atlas, D; Coupry, I; Parini, A; Podevin, RA; Uzielli, I | 1 |
| Breuiller, M; Ferré, F; Leroy, MJ; Litime, MH; Rouot, B | 1 |
| Berlan, M; Estan, L; Montastruc, JL; Senard, JM; Tran, MA | 1 |
| Berridge, CW; Dunn, AJ | 1 |
| Brasch, H; Kaschube, M | 1 |
| Dabiré, H; Mouille, P; Schmitt, H | 2 |
| Majewski, H; Rump, LC | 1 |
| Agnati, L; Fredholm, B; Fuxe, K; Härfstrand, A | 1 |
| Church, AC; Flexner, JB; Flexner, LB; Reynolds, EE | 1 |
| Atlas, D; Coupry, I; Graham, RM; Lanier, SM; Parini, A; Uzielli, I | 1 |
| Leighton, HJ; Ramagopal, MV | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Simonato, M; Spalluto, P; Tanganelli, S; Tomasini, C | 1 |
| Chapelain, B; Gargouil, YM; Mahe, L; Neliat, G | 1 |
| Majewski, H; Murphy, TV | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Mantzourides, T; Xiang, JZ | 1 |
| Limberger, N; Mayer, A; Singer, EA; Starke, K; Valenta, B; Zier, G | 1 |
| Jurcovicová, J; Krulich, L; Le, T | 1 |
| Martire, M; Navarra, P; Pistritto, G; Preziosi, P; Vacca, M | 1 |
| Dóda, M; Vizi, ES | 1 |
| Durcan, MJ; Linnoila, M; Lister, RG | 1 |
| Aslanian, V; Renaud, B | 1 |
| Grenhoff, J; Svensson, TH | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Mantzouridis, T; Xiang, JZ | 1 |
| Sanger, DJ | 1 |
| Curet, O; de Montigny, C | 1 |
| Coupry, I; Koenig, E; Lachaud, V; Parini, A; Podevin, RA | 1 |
| Carpéné, C; Lafontan, M; Langin, D; Saulnier-Blache, JS | 1 |
| Gregersen, H; Kraglund, K; Rittig, S; Tøttrup, A | 1 |
| Atterwill, CK; Bloomfield, JG; Bristow, LJ; Catto, LC; Elliott, JM; Heal, DJ | 1 |
| Martire, M; Pistritto, G; Preziosi, P | 1 |
| Drobny, H; Singer, EA; Valenta, B | 1 |
| Lattimer, N; Rhodes, KF; Sharma, S; Ward, TJ; Waterfall, JF; White, JF | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Rando, S; Simonato, M; Tanganelli, S | 1 |
| Hamilton, CA; Howie, CA; Reid, JL; Yakubu, MA | 1 |
| Lattimer, N; Rhodes, KF; Waterfall, JF | 1 |
| Loiacono, RE; Rand, MJ; Story, DF | 1 |
| Hicks, PE; Langer, SZ; Macrae, AD | 1 |
| Colpaert, FC; Janssen, PA | 1 |
| Joly, G; Mouillé, P; Schmitt, H | 1 |
| Arbilla, S; Benkirane, S; Langer, SZ | 1 |
| Bond, RA; Charlton, KG; Clarke, DE | 1 |
| György, L; Ludvig, N; Vizi, ES | 1 |
| Kaniucki, MD; Perec, CJ; Stefano, FJ | 1 |
| Curet, O; Dennis, T; L'Heureux, R; Scatton, B | 1 |
| Carlsson, M; Eriksson, E; Nilsson, C; Söderpalm, B | 1 |
| Livingston, A; Nolan, A; Waterman, A | 2 |
| Cardot, A; Dabire, H; Dausse, JP; Fournier, B; Meyer, P; Mouille, P; Schmitt, H | 1 |
| Bergsten, P; Hellman, B | 1 |
| Hicks, PE; Langer, SZ; Najar, M; Vidal, M | 1 |
| Bousquet, P; Feldman, J | 1 |
| Gellman, RL; Kallianos, JA; McNamara, JO | 1 |
| Diop, L; Kolta, A; Reader, TA | 1 |
| Convents, A; Convents, D; De Backer, JP; Vauquelin, G | 1 |
| Feder, HH; Thornton, J; Vincent, PA | 1 |
| Bamford, OS; Dawes, GS; Denny, R; Ward, RA | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Livingston, A; Morris, B | 1 |
| Blaustein, JD; Turcotte, J | 1 |
| Cannon de Rodriguez, W; Shaikh, IM; Skala, JP | 1 |
| Bouchenafa, O; Livingston, A; Waterman, A | 1 |
| Feldman, PD; Moises, HC | 1 |
| Tsurusaki, M | 1 |
| Cierpial, MA; Heyneman, LE; Simson, PE; Weiss, JM | 1 |
| Brasili, L; Cassinelli, A; Giardinà, D; Gulini, U; Melchiorre, C; Quaglia, W | 1 |
| Engel, J; Hård, E; Lindh, AS | 1 |
| Dirksen, R; Van der Laan, JW | 1 |
| Clarke, RW; Ford, TW; Taylor, JS | 1 |
| Fozard, JR; Ramage, AG | 1 |
| Barr, SM; Hamilton, CA; Reid, JL | 1 |
| Audiau, F; Benavides, J; Guérémy, C; Le Fur, G; Renault, C; Uzan, A | 1 |
| Engel, JA; Goldstein, M; Johannessen, K; Liljequist, S | 1 |
| Curet, O; Dennis, T; Scatton, B | 1 |
| de Champlain, J; Foucart, S; Nadeau, R | 1 |
| Duggan, AW; Zhao, ZQ | 1 |
| Krieger, AJ; Punnen, S; Sapru, HN; Urbanski, R | 1 |
| Andréjak, M; Dabiré, H; Fournier, B; Mouillé, P; Schmitt, H | 1 |
| Clifford, JM; Day, MD; Orwin, JM | 1 |
| Langer, SZ; Pimoule, C | 1 |
| Hamilton, CA; Hannah, JA; Reid, JL | 2 |
| Dabiré, H; Dausse, JP; Meyer, P; Mouillé, P; Schmitt, H | 1 |
| Doxey, JC; Roach, AG; Smith, CF | 1 |
| Dettmar, PW; Lynn, AG; Tulloch, IF | 1 |
| Kerry, R; Scrutton, MC | 1 |
| Qian, JQ; Ruffolo, RR; Timmermans, PB; van Zwieten, PA | 1 |
| Brown, MJ; Harland, D | 1 |
| Curtis-Prior, PB; Tan, S | 1 |
| Dedek, J; Scatton, B; Zivkovic, B | 1 |
| Cahusac, PM; Hill, RG | 1 |
| Scatton, B | 1 |
| Buckett, WR; Butler, SA; Cheetham, SC; Gosden, J; Heal, DJ; Prow, MR | 1 |
| Escribá, PV; García-Sevilla, JA; Miralles, A; Ozaita, A; Reis, DJ | 1 |
| Advenier, C; Biyah, K | 1 |
| Burroughs, GJ; Cole, JC; Laverty, CR; Rodgers, RJ; Sheriff, NC; Sparham, EA | 1 |
| Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG | 1 |
| Desmeules, J; Guilbaud, G; Kayser, V | 1 |
| Jane, F; Menargues, A; Obach, R; Pruñonosa, J; Valles, J | 1 |
| Dendorfer, A; Dominiak, P; Steffen, G | 1 |
| Evans, RG; Haynes, JM | 2 |
| Goiny, M; Herrera-Marschitz, M; Meana, JJ | 1 |
| Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Greney, H | 1 |
| Bousquet, P; Dontenwill, M; Greney, H; Molines, A | 1 |
| Gazzola, C; Hunter, RA; Lisle, AT; Magner, T | 1 |
| Finlay, JM; Gresch, PJ; Sved, AF; Zigmond, MJ | 1 |
| Kirk, HR; Monroe, PJ; Smith, DJ; Smith, DL | 1 |
| Baker, CH; Nessellroth, S; Ortiz-Tweed, M; Price, JM; Sutton, ET | 1 |
| Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G | 1 |
| Escribá, PV; García-Sevilla, JA; Regunathan, S; Reis, DJ; Sastre, M; Wang, H | 1 |
| Atrens, DM; Fleischhauer, AE; Kuhlman, SJ; Siviy, SM | 1 |
| Butler, S; Fulford, AJ; Heal, DJ; Kendall, DA; Marsden, CA | 1 |
| Aston, N; Chess-Williams, R; Couldwell, C | 1 |
| García-Sevilla, JA; Garro, MA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| Fukuda, H; Fukushima, C; Ono, H | 1 |
| Allen, AM; Guyenet, PG | 1 |
| Hamilton, CA; Jardine, E; Reid, JL | 1 |
| Cusack, NJ; Kelly, M; Martin, PL | 1 |
| Li, P; Smyth, DD | 1 |
| Anton, F; Dubner, R; Kenshalo, DR; Thomas, DA; Williams, GM | 1 |
| Robinson, NE; Wang, Z; Yu, M | 1 |
| Dunn, RW; La Marca, S | 1 |
| Corcoran, ME; Pelletier, MR | 1 |
| Godwin, SJ; Head, GA; Sannajust, F | 1 |
| Angel, I; Henquin, JC; Jonas, JC; Langer, SZ; Plant, TD | 1 |
| García-Sevilla, JA; Sastre, M | 1 |
| Blier, P; de Montigny, C; Mongeau, R | 1 |
| Hertz, L; Huang, R | 1 |
| Alcalde, O; Bier, M; Langer, J; Richkind, M; Shouse, MN; Szymusiak, R | 1 |
| Muskardin, DT; Wallace, DR; Zahniser, NR | 1 |
| Amabeoku, G; Chandomba, R | 1 |
| Boer, GJ; Feenstra, MG; van Veldhuizen, MJ | 1 |
| Gorman, AJ; Vargas, HM; Zhou, L | 1 |
| Bouloumié, A; Devedjian, JC; Lafontan, M; Planat, V; Record, M; Saulnier-Blache, JS; Valet, P | 1 |
| Anglade, G; Faudon, M; Grino, M; Paulmyer-Lacroix, O; Renard, M | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Greney, H; Stutzmann, J | 1 |
| Head, GA; Sannajust, F | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA | 1 |
| Bousquet, P; Bricca, G; De Backer, JP; De Keyser, J; De Vos, H; Vauquelin, G | 1 |
| Baker, DG; Brown, JK; Don, HF | 1 |
| Barturen, F; García-Sevilla, JA; García-Vallejo, P | 1 |
| Chapouthier, G; Jacquot, F; Sara, S; Save, E; Venault, P | 1 |
| Butelman, ER; Woods, JH | 1 |
| Brown, CM; MacKinnon, AC; Olverman, HJ; Spedding, M; Stewart, M | 1 |
| Angel, I; Grosset, A; Langer, SZ; Perrault, G; Schoemaker, H | 1 |
| Abercrombie, ED; Nisenbaum, LK | 1 |
| Detweiler, DJ; Eisenach, JC; Jackson, C; Tong, C | 1 |
| Agnati, LF; Frasoldati, A; Grimaldi, R; Marrama, P; Pich, EM; Zini, I | 1 |
| Hirokami, M; Ikeda, T; Matsumoto, M; Saito, H; Smith, CB; Tochihara, M; Togashi, H; Yoshioka, M | 1 |
| Hussain, JF; Kendall, DA; Wilson, VG | 1 |
| Asier Garro, M; García-Sevilla, JA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| Berridge, CW; Foote, SL; Page, ME; Valentino, RJ | 1 |
| Cervo, L; Rossi, C; Samanin, R | 1 |
| Chapman, IM; Kapoor, R; Willoughby, JO | 1 |
| Amabeoku, GJ | 1 |
| Piletz, JE; Sletten, K | 1 |
| Del Vecchio, RA | 1 |
| García-Sevilla, JA; Miralles, A; Olmos, G; Ribas, C | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill-Kieffer, M; Greney, H; Zhang, J | 1 |
| Oriowo, MA | 1 |
| Nutt, D; Smith, A | 1 |
| Felsen, D; Nassir, Y; Regunathan, S; Reis, DJ; Sundaram, K; Vaughan, ED | 1 |
| Ivankovich, AD; Kroin, JS; Lubenow, TR; McCarthy, RJ; Penn, RD | 1 |
| Redfern, WS; Williams, A | 1 |
| Gargalidis-Moudanos, C; Parini, A | 1 |
| Gietzen, DW; Jhanwar-Uniyal, M | 1 |
| Gaynor, PJ; Lookingland, KJ; Simmons, CR; Tucker, HA | 1 |
| Alcalde, O; Bier, M; Farber, PR; Langer, J; Moghimi, R; Richkind, M; Shouse, MN; Szymusiak, R | 2 |
| Bennai, F; Bousquet, P; Dontenwill, M; Greney, H; Vonthron, C | 1 |
| Chan, CK; Head, GA | 1 |
| Banyasz, T; Kovacs, T; O'Donnell, JM | 1 |
| Chayvialle, JA; Chéry-Croze, S; Détolle-Sarbach, S; Guez, D; Miampamba, M | 1 |
| Chou, RC; Ignatowski, TA; Spengler, RN | 1 |
| Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM | 1 |
| Nozaki-Taguchi, N; Yamamoto, T | 1 |
| Abadir, AR; Gintautas, J; Kraynack, BJ; Kwalburn, M; Mayda, J | 1 |
| Bustamante, D; Gozariu, M; Le Bars, D; Willer, JC | 1 |
| Abdel-Rahman, AA; Mao, L | 1 |
| Czerwiec, E; De Backer, JP; Flamez, A; Vauquelin, G | 1 |
| Camargo, LA; De Luca, LA; de Paula, PM; Menani, JV; Renzi, A; Saad, WA; Yada, MM | 1 |
| Colpaert, F; Marien, M; Tellez, S | 1 |
| Fulford, AJ; Marsden, CA | 2 |
| Ernsberger, P; Shen, IH | 1 |
| Czerwiec, E; De Backer, JP; Flamez, A; Ladure, P; Vauquelin, G | 1 |
| Bramwell, S; McGowan, D; Regunathan, S; Reis, DJ; Wang, H | 1 |
| Bousquet, P; Dontenwill, M; Ehrhardt, JD; Greney, H; Molines, A; Senecheau, P | 1 |
| Greven, J; Hohage, H; Schlatter, E | 1 |
| Bousquet, P; Dontenwill, M; Greney, H; Vonthron, C | 1 |
| De Backer, JP; Flamez, A; Gillard, M; Noyer, M; Vauquelin, G | 1 |
| Camargo, LA; De Luca Júnior, LA; Menani, JV; Renzi, A; Saad, WA; Sato, MA; Yada, MM | 1 |
| De Luca, LA; Menani, JV; Sato, MA; Sugawara, AM | 1 |
| Bol, CJ; Danhof, M; IJzerman, AP; Mandema, JW | 1 |
| Matsumoto, K; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Coupar, IM; Liu, L | 1 |
| El-Kadi, AO; Sharif, SI | 1 |
| Bailey, A; Clarke, G; Wakerley, J | 1 |
| Gaynor, PJ; Lookingland, KJ; Tucker, HA; West, CR | 1 |
| Greven, J; Hess, K; Hohage, H; Jahl, C; Schlatter, E | 1 |
| Bruandet, N; Debeer, L; Quintin, L; Rentero, N | 1 |
| Callado, LF; García-Sevilla, JA; Grijalba, B; Meana, JJ; Pazos, A; Sastre, M | 1 |
| Cools, AR; Koide, S; Koshikawa, N; Misaki, T; Murai, T; Takada, K; Yoshida, Y | 1 |
| Mason, R; Mundey, MK; Wilson, VG | 1 |
| Baertschi, AJ; Grubb, MC; Guyenet, PG; Pence, R; Stornetta, RL | 1 |
| Chen, WY; Mokha, SS; Peterson, AM; Wang, XM; Zhang, KM | 1 |
| Budai, D; Fields, HL; Harasawa, I | 1 |
| Björnberg, J; Ekelund, U; Mellander, S | 1 |
| Chopin, P; Colpaert, FC; Marien, M | 1 |
| Bousquet, P; Brasili, L; Carotti, A; Carrieri, A; Cavagna, R; Dontenwill, M; Gentili, F; Giannella, M; Leonetti, F; Piergentili, A; Pigini, M; Quaglia, W | 1 |
| Barbeau, H; Brustein, E; Chau, C; Giroux, N; Reader, TA; Rossignol, S | 1 |
| Gray, AM; Nevinson, MJ; Sewell, RD | 1 |
| Fukuhara, N; Ishikawa, T; Kinoshita, H; Nakanishi, O; Xiong, L | 1 |
| Kimura, K; Kise, M; Masui, Y; Niida, H; Shirouchi, Y; Tajima, K; Ueda, F; Yamamoto, O | 1 |
| Hasselblatt, A; Kowalewski, R; Leupolt, L; Rustenbeck, I | 1 |
| Aicher, SA; Drake, CT | 1 |
| Chung, JM; Coggeshall, RE; Han, HC; Lee, DH; Moon, DE; Xie, J | 1 |
| Bobirnac, I; Gazi, L; Loetscher, E; Parsley, S; Schoeffter, P | 1 |
| Bousquet, P; Dontenwill, M; Greney, H; Heemskerk, F; Magnier, C; Vonthron, C | 2 |
| De Backer, JP; Flamez, A; Ladure, P; Vauquelin, G | 1 |
| Danbury, TC; Hudson, AL; Kestin, SC; Ruban, B; Waterman-Pearson, AE | 1 |
| Ricci, D; Taira, CA | 1 |
| Agouzoul, D; Middleton, HC; Robbins, TW; Sahakian, BJ; Sharma, A | 1 |
| Mateo, Y; Meana, JJ | 1 |
| Nott, MW; Rand, MJ; Thaina, P | 1 |
| Arnsten, AF; Franowicz, JS | 1 |
| Bernini, M; Bianchetti, A; Invernizzi, RW; Parini, S; Sacchetti, G; Samanin, R | 1 |
| Lundeberg, T; Petersson, M; Uvnäs-Moberg, K | 1 |
| Fukazawa, H; Ishida, H; Koda, H; Kuriyama, K; Matsumoto, N; Nukaya, H; Suwa, Y; Tsuji, K; Yokoo, Y | 1 |
| Browning, KN; Lees, GM | 1 |
| Covey, WC; Ignatowski, TA; Knight, PR; Spengler, RN | 1 |
| Grottick, AJ; Herberg, LJ; Montgomery, AM | 2 |
| Benamour, K; Chang-Fong, J; Cussac, M; Morand, JM; Szymonski, B; Thomasson, F | 1 |
| Eisenach, JC; Li, X; Pan, HL; Paqueron, X; Zhao, Z | 1 |
| Baldwin, J; Chang, CH; Ernsberger, P; Gold, G; Ivanov, TR; Jones, JC; Pickard, RT; Piletz, JE; Reis, DJ; Roth, B; Sharp, JD; Zhu, H | 1 |
| Baliko, CN; Siviy, SM | 1 |
| Colpaert, FC; Pauwels, PJ | 1 |
| Bitar, MS; Pilcher, CW | 1 |
| Bernini, M; Gobbi, M; Mennini, T; Parini, S; Pirona, L; Sacchetti, G; Samanin, R | 1 |
| Freedman, JE; Murphy, R | 1 |
| Holzer, P; Painsipp, E | 1 |
| Busquets, X; García-Sevilla, JA; Miralles, A; Ribas, C | 1 |
| Anderson, M; Burleigh, D | 1 |
| Bisgard, GE; Herman, JK; O'Halloran, KD | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Devoto, P; Flore, G; Gessa, GL; Pani, L | 1 |
| Bishai, JM; Buchholz, JN; Gheorghe, CP; Longo, LD; Meulenaar, R; Nijland, R; Penninga, L; Zhang, L; Zhao, Y | 1 |
| Coruzzi, G; Poli, E; Pozzoli, C; Schunack, W; Timmerman, H; Todorov, S | 1 |
| Blier, P; Szabo, ST | 1 |
| Cheng, JT; Chuang, YC; Lin, CR; Wang, CJ; Yang, LC | 1 |
| Bouysset, F; Cordi, A; Laubie, M; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Antonio De Luca, L; Oliveira Margatho, L; Pereira Barbosa, S; Vanderlei Menani, J | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Artigues-Varin, C; Mulder, P; Richard, V; Thuillez, C; Varin, R | 1 |
| Garcez-do-Carmo, L; Jurkiewicz, A; Piçarro, I; Santos, WC; Smaili, SS | 1 |
| Pan, YX; Ren, AJ; Su, DF; Tang, CS; Wang, WZ; Yuan, WJ | 1 |
| Brazhnik, ES; Kitchigina, VF; Kutyreva, EV | 1 |
| Raasmaja, A; Römer, L; Savola, JM; Wurster, S | 1 |
| Brock, JA; McLachlan, EM; Yeoh, M | 1 |
| Cardin, JA; Schmidt, MF | 1 |
| Bannova, AV; Dygalo, NN; Kalinina, TS; Shishkina, GT | 1 |
| Shen, FM; Su, DF; Wang, WZ; Yang, J | 1 |
| Barrondo, S; Callado, LF; Martín-Gómez, JI; Meana, JJ; Ruiz, J | 1 |
| Anderson, NJ; Hudson, AL; Lupo, PA; Nutt, DJ; Robinson, ES | 1 |
| Brock, JA; Yeoh, M | 1 |
| Honda, M; Kino, Y; Ono, H; Tanabe, M | 1 |
| Amano, T; Ebiko, M; Kimura, Y; Sakurada, S; Yonezawa, A; Yoshizumii, M | 1 |
| Bönisch, H; Brüss, M; Caron, MG; Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gilsbach, R; Rogóz, Z | 1 |
| Feliu-Mojer, M; Jiménez-Rivera, CA; Vázquez-Torres, R | 1 |
| de Lanerolle, N; Farber, PR; Scordato, JC; Shouse, MN | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Andurkar, SV; Bhalla, S; Gulati, A; Matwyshyn, G; Zhang, Z | 1 |
| Dawe, GS; Jay, TM; Lim, EP; Tan, CH | 1 |
| Arszol, C; Bartenstein, P; Böning, G; Cumming, P; Josef Gildehaus, F; Mille, E; Rominger, A; Wängler, B | 1 |
| Chopde, CT; Gahane, AY; Kotagale, NR; Taksande, BG; Ugale, RR | 1 |
| Bennett, DJ; D'Amico, J; Gorassini, MA; Murray, KC; Rank, MM; Stephens, MJ | 1 |
| Andurkar, SV; Bhalla, S; Gulati, A | 1 |
| Gooneratne, SR | 1 |
| Kuo, SP; Trussell, LO | 1 |
| Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P | 1 |
| Gerlach, M; Halley, P; Riederer, P; van den Buuse, M | 1 |
| Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Takada, K; Uchida, T; Verheij, MM | 1 |
| Cano, G; Madden, CJ; Morrison, SF; Tupone, D | 1 |
| Brock, JA; McLachlan, EM; Tripovic, D | 1 |
| Aglawe, MM; Chopde, CT; Kotagale, NR; Taksande, BG; Tripathi, SJ; Umekar, MJ | 1 |
| Priyanka, HP; ThyagaRajan, S | 1 |
| Cevreli, B; Ozcetin, A; Uzbay, T | 1 |
| Dawe, GS; Jay, TM; Lim, EP | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M; Yamazato, Y | 1 |
3 review(s) available for clonidine and idazoxan
| Article | Year |
|---|---|
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Humans; Molecular Conformation; Molecular Structure; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1995 |
The role of imidazoline receptors in blood pressure regulation.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Blood Pressure; Clonidine; Dioxanes; Heart Rate; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Norepinephrine; Receptors, Drug | 1992 |
Pharmacology and biochemistry of noradrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Dioxins; Idazoxan; Muscle, Smooth, Vascular; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sympathectomy, Chemical; Vasoconstriction | 1982 |
6 trial(s) available for clonidine and idazoxan
| Article | Year |
|---|---|
Presynaptic alpha 2-adrenoceptor function and sleep in man: studies with clonidine and idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Clonidine; Dioxanes; Double-Blind Method; Humans; Idazoxan; Male; Maprotiline; Neurotransmitter Uptake Inhibitors; Norepinephrine; Receptors, Adrenergic, alpha; Sleep Stages | 1991 |
Pharmacology of saccadic eye movements in man. 2. Effects of the alpha 2-adrenoceptor ligands idazoxan and clonidine.
Topics: Adrenergic alpha-Antagonists; Adult; Arousal; Blood Pressure; Clonidine; Dioxanes; Double-Blind Method; Electrooculography; Female; Heart Rate; Humans; Hypnotics and Sedatives; Idazoxan; Male; Saccades | 1991 |
Reversal of clonidine induced miosis by the alpha 2-adrenoreceptor antagonist RX 781094.
Topics: Adrenergic alpha-Antagonists; Clonidine; Dioxins; Humans; Idazoxan; Pupil | 1982 |
A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Dioxanes; Female; Humans; Idazoxan; Imidazoles; Injections, Spinal; Medetomidine; Receptors, Cholinergic; Sheep | 1993 |
Noradrenaline and attention lapses.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Attention; Clonidine; Dioxanes; Humans; Idazoxan; Imidazoles; Norepinephrine | 1996 |
Idazoxan potentiates rather than antagonizes some of the cognitive effects of clonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Blood Pressure; Clonidine; Cognition; Cross-Over Studies; Drug Synergism; Female; Humans; Idazoxan; Learning; Locus Coeruleus; Male; Receptors, Adrenergic, alpha-2; Single-Blind Method | 1999 |
350 other study(ies) available for clonidine and idazoxan
| Article | Year |
|---|---|
Heteroaromatic analogues of the alpha 2-adrenoreceptor partial agonist clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Heterocyclic Compounds; Male; Rats; Vas Deferens | 1989 |
Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; Imidazoles; Male; Mice; Muscle Contraction; Phenylephrine; Piperidines; Piperoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Structure-Activity Relationship | 1986 |
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Imidazoles; Indoles; Male; Mice; Nociceptors; Pain; Prazosin; Quinolines; Rats; Structure-Activity Relationship; Vas Deferens | 1987 |
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Dioxins; Dose-Response Relationship, Drug; Idazoxan; Male; Mice; Phenylephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synapses; Vas Deferens | 1983 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biogenic Amines; Brain; In Vitro Techniques; Indoles; Magnetic Resonance Spectroscopy; Parasympatholytics; Pyridines; Rats; Structure-Activity Relationship | 1996 |
Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cattle; Frontal Lobe; Heart Rate; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kidney; Oxazines; Rabbits; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 2003 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Binding, Competitive; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazoles; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stilbenes; Structure-Activity Relationship; Tetrahydronaphthalenes | 2008 |
QSAR study of imidazoline antihypertensive drugs.
Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship | 2008 |
Novel synthesis and pharmacological evaluation as alpha2-adrenoceptor ligands of O-phenylisouronium salts.
Topics: Adrenergic alpha-2 Receptor Antagonists; Antidepressive Agents; Brain; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; Ligands; Models, Molecular; Molecular Structure; Salts; Stereoisomerism; Structure-Activity Relationship; Sulfides; Urea | 2008 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Microdialysis; Neurons; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2009 |
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine | 2016 |
Clonidine inhibition of norepinephrine release from normal and morphine-tolerant guinea pig cortical slices.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Dioxanes; Drug Tolerance; Electric Stimulation; Female; Guinea Pigs; Idazoxan; In Vitro Techniques; Male; Morphine; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Opioid; Reference Values | 1992 |
Alpha 2-adrenoceptor modulation of rat ventral hippocampal 5-hydroxytryptamine release in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Hippocampus; Idazoxan; Male; Pindolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Thiazoles; Tyrosine 3-Monooxygenase | 1992 |
Differential localization of alpha 2-adrenergic receptor subtypes in brain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain Chemistry; Clonidine; Dioxanes; Guanylyl Imidodiphosphate; Idazoxan; Male; Perfusion; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tritium; Yohimbine | 1992 |
Cardiovascular responses of sinoaortic-denervated rats to intracerebroventricular injection of alpha 1- and alpha 2-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Denervation; Dioxanes; Heart Rate; Idazoxan; Injections, Intraventricular; Phenylephrine; Prazosin; Pressoreceptors; Rats; Rats, Inbred Strains | 1992 |
Presynaptic alpha 2-adrenoceptors mediating inhibition of noradrenaline and 5-hydroxytryptamine release in rat cerebral cortex: further characterization as different alpha 2-adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Dioxanes; Ethylmaleimide; GTP-Binding Proteins; Idazoxan; In Vitro Techniques; Male; Mianserin; Nerve Endings; Norepinephrine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Signal Transduction; Synaptosomes; Thiazoles | 1992 |
Alpha 2-autoreceptor-mediated modulation of tyrosine hydroxylase activity in noradrenergic regions of the rat brain in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Dihydroxyphenylalanine; Dioxanes; Idazoxan; Injections, Intraperitoneal; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase | 1992 |
Studies on the origin of rat hippocampal dihydroxyphenylacetic acid using microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clonidine; Dialysis; Dioxanes; Dopamine; Efferent Pathways; Ergolines; Hippocampus; Idazoxan; Locus Coeruleus; Male; Microchemistry; Norepinephrine; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Sulpiride; Tyrosine 3-Monooxygenase | 1992 |
Intrathecal clonidine and the response to hemorrhage.
Topics: Adrenergic alpha-Antagonists; Animals; Catecholamines; Clonidine; Dioxanes; Female; Hemodynamics; Idazoxan; Imidazoles; Injections, Spinal; Sheep; Shock | 1992 |
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1992 |
Alpha 2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Clonidine; Dioxanes; Idazoxan; Male; Norepinephrine; Oxidopamine; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Serotonin; Tryptophan | 1992 |
Evidence for noradrenergic involvement in mediating the FG 7142 discriminative stimulus.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Carbolines; Clonidine; Dioxanes; Discrimination, Psychological; Electroshock; Generalization, Stimulus; Idazoxan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Stress, Psychological; Yohimbine | 1992 |
Alpha-2 adrenergic agonists decrease distractibility in aged monkeys performing the delayed response task.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Attention; Benzazepines; Clonidine; Cognition; Conditioning, Operant; Dioxanes; Female; Idazoxan; Macaca mulatta; Memory; Psychomotor Performance | 1992 |
Potent antinociceptive effects of clonidine systemically administered in an experimental model of clinical pain, the arthritic rat.
Topics: Adrenergic beta-Antagonists; Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Clonidine; Dioxanes; Idazoxan; Injections, Intravenous; Male; Pain; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Vocalization, Animal; Yohimbine | 1992 |
Calcium entry blockade as a mechanism for chlordimeform-induced inhibition of motor activity in the isolated guinea-pig ileum.
Topics: Adrenergic alpha-Antagonists; Animals; Chlorphenamidine; Clonidine; Dioxanes; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Peristalsis | 1992 |
Identification of alpha 2 adrenoceptors in the human nucleus olivarius by radioligand binding.
Topics: Adrenergic alpha-Agonists; Aged; Binding, Competitive; Brain Chemistry; Clonidine; Dioxanes; Epinephrine; Humans; Idazoxan; Middle Aged; Olivary Nucleus; Radioligand Assay; Receptors, Adrenergic, alpha | 1992 |
The effects of (+/-)-idazoxan and its stereoisomers on mouse vas deferens motility in vitro. A comparison with yohimbine.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Male; Mice; Norepinephrine; Stereoisomerism; Vas Deferens; Yohimbine | 1992 |
Interrelation between alpha 2-adrenoreceptor system and neuropeptide Y in rat nucleus tractus solitarii.
Topics: Animals; Blood Pressure; Clonidine; Dioxanes; Heart Rate; Idazoxan; Immunization, Passive; Kinetics; Male; Medulla Oblongata; Neuropeptide Y; Nordefrin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Role of alpha-adrenoceptors in control of plasma potassium in conscious rabbits.
Topics: Animals; Apamin; Calcium Channels; Clonidine; Dioxanes; Ethanolamines; Hyperkalemia; Idazoxan; Potassium; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Verapamil | 1991 |
Changes in plasma glucose and lactate evoked by alpha and beta 2-adrenoceptor stimulation in conscious fasted rabbits.
Topics: Albuterol; Analysis of Variance; Animals; Blood Glucose; Clonidine; Dioxanes; Epinephrine; Fasting; Idazoxan; Lactates; Male; Picolinic Acids; Prazosin; Propanolamines; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Spectrophotometry | 1991 |
An imidazoline-specific mechanism for the hypotensive effect of clonidine: a study with yohimbine and idazoxan.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain Stem; Clonidine; Dioxanes; Heart Rate; Idazoxan; Locus Coeruleus; Male; Rats; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Role of ventrolateral medulla in sympatholytic effect of 8-OHDPAT in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; Lumbosacral Region; Male; Medulla Oblongata; Neurons; Pressoreceptors; Rats; Rats, Inbred Strains; Reflex; Sympathetic Nervous System; Sympatholytics; Tetrahydronaphthalenes; Yohimbine | 1991 |
Site of hemodynamic effects of intrathecal alpha 2-adrenergic agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Hemodynamics; Idazoxan; Injections, Spinal; Sheep | 1991 |
No influence of prejunctional alpha 2-adrenoceptors on the effects of nicotine and tyramine in guinea-pig atria.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Guinea Pigs; Heart; Idazoxan; In Vitro Techniques; Male; Myocardial Contraction; Nicotine; Receptors, Adrenergic, alpha; Tetrodotoxin; Tyramine | 1991 |
Clonidine causes antidepressant-like effects in rats by activating alpha 2-adrenoceptors outside the locus coeruleus.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Clonidine; Desipramine; Dioxanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Hydroxydopamines; Idazoxan; Locus Coeruleus; Male; Neurons; Norepinephrine; Oxidopamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Injections, Spinal; Male; Motor Activity; Naloxone; Neuropeptide Y; Pain; Parasympathomimetics; Peptide Fragments; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1991 |
Alpha-2 adrenoreceptors mediate clonidine-induced hypoinsulinaemia in sheep.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Clonidine; Dioxanes; Eating; Female; Idazoxan; Injections, Intravenous; Insulin; Male; Prazosin; Receptors, Adrenergic, alpha; Sheep | 1991 |
GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Clonidine; Decerebrate State; Dioxanes; Electric Stimulation; Heart Rate; Idazoxan; Phentolamine; Phenylephrine; Pyridazines; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
Behavioral models in mice. Implication of the alpha noradrenergic system.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Depression; Dioxanes; Hydroxamic Acids; Idazoxan; Male; Mice; Motor Activity; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Swimming | 1991 |
Effects of alpha-noradrenergic substances on the optokinetic and vestibulo-ocular responses in the rabbit: a study with systemic and intrafloccular injections.
Topics: Adaptation, Physiological; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cerebellum; Clonidine; Dioxanes; Eye Movements; Female; Idazoxan; Injections, Intravenous; Male; Microinjections; Phenylephrine; Prazosin; Rabbits; Reflex, Vestibulo-Ocular | 1991 |
3-Methoxy-4-hydroxyphenylethyleneglycol concentrations in discrete hypothalamic nuclei reflect the activity of noradrenergic neurons.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Hypothalamus; Idazoxan; Locus Coeruleus; Male; Medial Forebrain Bundle; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Stress, Psychological; Supraoptic Nucleus | 1991 |
Alpha-adrenoceptor blocking properties of vesamicol.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Corticosterone; Desipramine; Dioxanes; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Vas Deferens | 1991 |
Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Catecholamines; Clonidine; Dioxanes; Electrochemistry; Hemodynamics; Idazoxan; Imidazoline Receptors; Male; Medulla Oblongata; Neurons; Oxazoles; Piperoxan; Rats; Rats, Inbred WKY; Receptors, Drug; Reticular Formation; Rilmenidine; Stereotaxic Techniques; Yohimbine | 1991 |
Effects of drugs influencing the noradrenergic neurotransmission on nonepileptic myoclonus of Papio papio baboon.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; Myoclonus; Norepinephrine; Papio; Phenylephrine; Propranolol; Synaptic Transmission | 1991 |
In vivo modulation of the histamine release in the hypothalamus by adrenoreceptor agonists and antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Histamine Release; Hypothalamus; Idazoxan; Male; Norepinephrine; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
Clonidine-displacing substance from bovine brain binds to imidazoline receptors and releases catecholamines in adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Brain; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Clonidine; Dioxanes; Idazoxan; Imidazoline Receptors; Kinetics; Membranes; Receptors, Drug; Tritium | 1991 |
Clonidine inhibition of potassium-evoked release of glutamate and aspartate from rat cortical synaptosomes.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cerebral Cortex; Clonidine; Dioxanes; gamma-Aminobutyric Acid; Glutamates; Idazoxan; Kinetics; Male; Potassium; Potassium Chloride; Rats; Rats, Inbred Strains; Synaptosomes; Yohimbine | 1991 |
Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat.
Topics: Animals; Clonidine; Corticosterone; Desipramine; Dioxanes; Growth Hormone; Hypothalamo-Hypophyseal System; Idazoxan; Injections, Intravenous; Male; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Imidazole binding sites in rabbit kidney and forebrain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Clonidine; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kidney; Kinetics; Norepinephrine; Parasympathetic Nervous System; Rabbits; Sympathetic Nervous System; Yohimbine | 1991 |
Modulation of rat brain cortical alpha 2-adrenoceptors by treatment with hydrocortisone for 10 days.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Dioxanes; Hydrocortisone; Idazoxan; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors | 1990 |
Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral nociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Idazoxan; Male; Pain; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1990 |
Biochemical and radiohistochemical analyses of alpha-2 adrenergic receptors in the kindling model of epilepsy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain; Cell Membrane; Clonidine; Dioxanes; Epilepsy; Idazoxan; Kindling, Neurologic; Male; Models, Neurological; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
Mutual interaction between presynaptic alpha 2-adrenoceptors and 5-HT1B receptors on the sympathetic nerve terminals of the rat inferior vena cava.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Azepines; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin; Tritium; Vena Cava, Inferior | 1990 |
Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro.
Topics: Adrenergic alpha-Antagonists; Amino Acids; Animals; Brain; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imipramine; Male; Neurotransmitter Uptake Inhibitors; Prazosin; Rats; Receptors, Adrenergic, alpha; Synaptosomes; Vas Deferens | 1990 |
[Implication of alpha-2 adrenergic post-synaptic receptors in the central catecholaminergic stimulation of the corticotropic axis in rats].
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Clonidine; Depression, Chemical; Dioxanes; Drug Therapy, Combination; Female; Idazoxan; Injections, Intraventricular; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1990 |
Imidazoline receptors in rat liver cells: a novel receptor or a subtype of alpha 2-adrenoceptors?
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Platelets; Clonidine; Dioxanes; Guanidines; Humans; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Liver; Lung; Male; Membranes; Potassium Channels; Rats; Receptors, Adrenergic, alpha; Receptors, Drug | 1990 |
Effect of BHT 920 on monoaminergic neurons of the rat brain: an electrophysiological in vivo and in vitro study.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Azepines; Biogenic Monoamines; Brain; Clonidine; Dioxanes; Dopamine Agents; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Neurons; Raphe Nuclei; Rats; Rats, Inbred Strains; Sulpiride; Tegmentum Mesencephali | 1990 |
Modulation of 5-hydroxytryptamine release by presynaptic inhibitory alpha 2-adrenoceptors in the human cerebral cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Animals; Cerebral Cortex; Clonidine; Dioxanes; Female; Guinea Pigs; Humans; Idazoxan; In Vitro Techniques; Male; Methoxamine; Middle Aged; Prazosin; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1990 |
Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance.
Topics: Amiloride; Animals; Binding Sites; Clonidine; Dioxanes; Dioxins; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Kidney Tubules, Proximal; Magnesium; Male; Potassium; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Yohimbine | 1990 |
Functional coupling of the alpha 2-adrenergic receptor-adenylate cyclase complex in the pregnant human myometrium.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adult; Binding, Competitive; Clonidine; Colforsin; Cyclic AMP; Dioxanes; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Female; GTP-Binding Proteins; Humans; Idazoxan; Myometrium; Norepinephrine; Pertussis Toxin; Pregnancy; Pregnancy Trimester, Third; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella; Yohimbine | 1990 |
Reserpine induces vascular alpha 2-adrenergic supersensitivity and platelet alpha 2-adrenoceptor up-regulation in dog.
Topics: Adipose Tissue; Animals; Blood Platelets; Blood Pressure; Cardiovascular System; Catecholamines; Cell Membrane; Clonidine; Dioxanes; Dogs; Heart Rate; Idazoxan; Male; Norepinephrine; Posture; Prazosin; Receptors, Adrenergic, alpha; Reserpine; Up-Regulation; Yohimbine | 1990 |
DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment.
Topics: Animals; Benzylamines; Brain Chemistry; Cerebral Cortex; Clonidine; Dioxanes; Exploratory Behavior; Hippocampus; Idazoxan; Male; Methoxyhydroxyphenylglycol; Mice; Norepinephrine; Phenylephrine; Prazosin; Restraint, Physical; Sympathomimetics | 1990 |
Pre- and postjunctional effects of N-ethylmaleimide in the isolated mouse vas deferens.
Topics: 2-Chloroadenosine; Animals; Bethanechol Compounds; Calcium Chloride; Clonidine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dioxanes; Electric Stimulation; Ethylmaleimide; Idazoxan; In Vitro Techniques; Male; Mice; Muscle, Smooth; Norepinephrine; Vas Deferens | 1990 |
(Imidazolinyl-2)-2-benzodioxane 1-4 (idazoxan) and its stereoisomers, new alpha 2-antagonists.
Topics: Animals; Azepines; Chickens; Clonidine; Dioxanes; Dioxins; Heart Rate; Idazoxan; Imidazoles; Male; Mice; Muscle Contraction; Rats; Receptors, Adrenergic, alpha; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1985 |
Modulation of norepinephrine release through alpha 1- and alpha 2-adrenoceptors in rat isolated kidney.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Kidney; Male; Norepinephrine; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System | 1987 |
Reciprocal interactions between alpha 2-adrenoceptor agonist and neuropeptide Y binding sites in the nucleus tractus solitarius of the rat. A biochemic and autoradiographic analysis.
Topics: Animals; Binding, Competitive; Clonidine; Dioxanes; Idazoxan; Kinetics; Male; Medulla Oblongata; Neuropeptide Y; Quinolines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Neuropeptide Y; Receptors, Neurotransmitter; Subcellular Fractions | 1989 |
Long-term suppression of the cerebral spread of a memory: effects of idazoxan and clonidine.
Topics: Animals; Clonidine; Dioxanes; Dioxins; Female; Idazoxan; Male; Memory; Mice; Puromycin; Receptors, Adrenergic, alpha | 1989 |
Characterization of an imidazoline/guanidinium receptive site distinct from the alpha 2-adrenergic receptor.
Topics: Animals; Binding Sites; Chromatography, Affinity; Clonidine; Dioxanes; Glycosylation; Guanidine; Guanidines; Idazoxan; Imidazoles; Kidney Tubules, Proximal; Male; Rabbits; Receptors, Adrenergic, alpha | 1989 |
Analysis of the presence of postjunctional alpha-2 adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Phenoxybenzamine; Prazosin; Rats; Receptors, Adrenergic, alpha; Regression Analysis | 1989 |
Changes in cortical acetylcholine and gamma-aminobutyric acid outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors.
Topics: Acetylcholine; Animals; Clonidine; Dioxanes; Female; gamma-Aminobutyric Acid; Guinea Pigs; Idazoxan; Locus Coeruleus; Male; Morphine; Naloxone; Prazosin; Receptors, Adrenergic, alpha; Substance Withdrawal Syndrome | 1989 |
The role of alpha- and beta-adrenoceptors in the response to noradrenaline of lymphatic vessels isolated from the bovine mesentery.
Topics: Animals; Cattle; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Lymphatic System; Mesentery; Methoxamine; Norepinephrine; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1989 |
Modulation of noradrenaline release in slices of rat kidney cortex through alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Indomethacin; Kidney Cortex; Male; Methoxamine; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation; Theophylline | 1989 |
Presynaptic alpha 2-adrenoceptor and kappa-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzofurans; Calcium; Calcium Channels; Clonidine; Dioxanes; Fura-2; Idazoxan; In Vitro Techniques; Male; Mollusk Venoms; Naloxone; Neurons; Nifedipine; omega-Conotoxin GVIA; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptosomes | 1989 |
Estimation of pA2 values at presynaptic alpha 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition.
Topics: Animals; Cerebral Cortex; Clonidine; Desipramine; Dioxanes; Electric Stimulation; Female; Idazoxan; In Vitro Techniques; Kinetics; Male; Nordefrin; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Synapses; Yohimbine | 1989 |
Prolactin (PRL) release-inhibiting properties of the alpha 2 adrenergic receptor antagonist idazoxan: comparison with yohimbine.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Clonidine; Dioxanes; Dioxins; Growth Hormone; Idazoxan; Kinetics; Male; Morphine; Norepinephrine; Prazosin; Prolactin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Restraint, Physical; Yohimbine | 1989 |
Prolactin-lowering ability of (+/-)-idazoxan may be linked to a central noradrenergic-serotonergic interplay.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Dioxanes; Dioxins; Female; Idazoxan; Lactation; Male; Norepinephrine; Pregnancy; Prolactin; Rats; Receptors, Dopamine; Receptors, Serotonin; Serotonin | 1989 |
Effect of CH-38083, a selective antagonist of alpha 2-adrenoceptors, on renal sympathetic function.
Topics: Adrenergic alpha-Antagonists; Animals; Berberine; Berberine Alkaloids; Blood Pressure; Cats; Clonidine; Dimethylphenylpiperazinium Iodide; Dioxanes; Female; Idazoxan; Kidney; Male; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Xylazine | 1989 |
Interactions of alpha 2-adrenoceptor antagonists with medetomidine and with ethanol in a holeboard test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Ethanol; Idazoxan; Imidazoles; Male; Medetomidine; Mice | 1989 |
Changes in serotonin metabolism in the rat raphe magnus and cardiovascular modifications following systemic administration of clonidine and other central alpha 2-agonists: an in vivo voltammetry study.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dioxanes; Electrochemistry; Heart Rate; Hemodynamics; Idazoxan; Imidazoles; Immunohistochemistry; Male; Medetomidine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Clonidine modulates dopamine cell firing in rat ventral tegmental area.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dopamine; Idazoxan; Male; Neurons; Rats; Tegmentum Mesencephali; Yohimbine | 1989 |
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Caffeine; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Fluorescent Dyes; Fura-2; Homeostasis; Idazoxan; Male; Naloxone; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Synaptosomes | 1989 |
Discriminative stimulus effects of the alpha 2-adrenoceptor antagonist idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dioxins; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Idazoxan; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. III. Evidence for the physiological role of terminal alpha 2-adrenergic autoreceptors.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electric Stimulation; Hippocampus; Idazoxan; Locus Coeruleus; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Guanfacine; Guanidines; Idazoxan; Kidney Tubules, Proximal; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine | 1989 |
Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cricetinae; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipolysis; Male; Mesocricetus; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
The effect of a new selective alpha 2-adrenoreceptor antagonist, idazoxan, and the agonist, clonidine, on fasting antroduodenal motility in healthy volunteers.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Blood Pressure; Clonidine; Dioxanes; Duodenum; Gastrointestinal Motility; Heart Rate; Humans; Idazoxan; Male; Pyloric Antrum | 1989 |
The influence of L-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on alpha 2- and beta-adrenoceptor function in the brain of the rat: implications for the potentiation of antidepressant therapy by
Topics: Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Dioxanes; Electroshock; Idazoxan; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Triiodothyronine | 1987 |
Alpha 2-adrenoceptor blocking properties of idazoxan stereoisomers: stereoselectivity for presynaptic alpha 2-adrenoceptors.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Dioxins; Hypothalamus; Idazoxan; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Synaptosomes | 1988 |
Presynaptic autoinhibition of central noradrenaline release in vitro: operational characteristics and effects of drugs acting at alpha-2 adrenoceptors in the presence of uptake inhibition.
Topics: Animals; Brain; Clonidine; Desipramine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Tritium | 1988 |
Synthesis and structure-activity relationships of 2-sulfonamido-1,3,4,6,7,11b alpha-hexahydro-2H-benzo[a]quinolizines as alpha 2-adrenoceptor antagonists.
Topics: Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Idazoxan; Male; Methoxamine; Molecular Conformation; Muscle Contraction; Muscles; Quinolizines; Rats; Receptors, Adrenergic, alpha; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Vas Deferens; Yohimbine | 1988 |
Inversion of the alpha-2 and alpha-1 noradrenergic control of the cortical release of acetylcholine and gamma-aminobutyric acid in morphine-tolerant guinea pigs.
Topics: Acetylcholine; Animals; Cerebral Cortex; Clonidine; Dioxanes; Drug Tolerance; Female; gamma-Aminobutyric Acid; Guinea Pigs; Idazoxan; Locus Coeruleus; Male; Morphine; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha | 1988 |
Idazoxan and brain alpha 2-adrenoceptors in the rabbit.
Topics: Animals; Brain; Clonidine; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Idazoxan; Injections, Intravenous; Rabbits; Receptors, Adrenergic, alpha; Time Factors; Yohimbine | 1988 |
Studies of alpha 2-adrenoceptor antagonist potency in vitro: comparisons in tissues from rats, rabbits, dogs and humans.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Dioxanes; Dogs; Humans; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation; Quinolizines; Rabbits; Rats; Rats, Inbred Strains; Saphenous Vein; Species Specificity; Vas Deferens; Yohimbine | 1985 |
Interaction between the inhibitory action of acetylcholine and the alpha-adrenoceptor autoinhibitory feedback system on release of [3H]-noradrenaline from rat atria and rabbit ear artery.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Arteries; Catecholamines; Clonidine; Dioxanes; Ear; Electric Stimulation; Feedback; Female; Heart Atria; Idazoxan; Imidazolines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Norepinephrine; Phentolamine; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1985 |
Differential blocking actions of idazoxan against the inhibitory effects of 6-fluoronoradrenaline and clonidine in the rat vas deferens.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cocaine; Dioxanes; Dioxins; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pargyline; Rats; Reserpine; Vas Deferens | 1985 |
Discriminative stimulus properties of xylazine in rat: discriminability and effects of putative alpha-2 adrenoceptor agonists and antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Discrimination Learning; Idazoxan; Lisuride; Lysergic Acid Diethylamide; Male; Piperoxan; Rats; Rats, Inbred Strains; Thiazines; Xylazine; Yohimbine | 1985 |
Antagonistic effects of S9871 or (imidazolinyl-2)-2-dihydro 2,3 benzofurane and its stereoisomers on some central and peripheral actions of alpha 2-agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Decerebrate State; Dioxanes; Electric Stimulation; Hypnotics and Sedatives; Idazoxan; Injections, Intraventricular; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
Supersensitivity of alpha 2-adrenoceptors modulating [3H]5-HT release after noradrenergic denervation with DSP4.
Topics: Adrenergic alpha-Antagonists; Amines; Animals; Benzylamines; Clonidine; Desipramine; Dioxanes; Electric Stimulation; Hippocampus; Idazoxan; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Serotonin; Sympathectomy, Chemical | 1985 |
Responses to norepinephrine resistant to inhibition by alpha and beta adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Cystamine; Dioxanes; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Nordefrin; Norepinephrine; Receptors, Adrenergic; Reserpine; Yohimbine | 1986 |
Evidence that serotonin receptors are involved in the anticonvulsant effect of yohimbine in mice.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Azepines; Clonidine; Dioxanes; Electroshock; Idazoxan; Male; Metergoline; Methysergide; Mice; Quipazine; Receptors, Serotonin; Serotonin Antagonists; Yohimbine | 1986 |
Blockade of postsynaptic alpha 2-adrenoceptors enhances responses to mixed alpha 1/alpha 2-agonists in rat submaxillary gland.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Idazoxan; Isoproterenol; Nordefrin; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Saliva; Submandibular Gland | 1986 |
Measurement of endogenous noradrenaline release in the rat cerebral cortex in vivo by transcortical dialysis: effects of drugs affecting noradrenergic transmission.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Calcium; Cerebral Cortex; Clonidine; Desipramine; Dialysis; Dioxanes; Edetic Acid; Idazoxan; Male; Microchemistry; Norepinephrine; Rats; Rats, Inbred Strains | 1986 |
Does alprazolam, in contrast to diazepam, activate alpha 2-adrenoceptors involved in the regulation of rat growth hormone secretion?
Topics: Adrenergic alpha-Antagonists; Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Clonidine; Diazepam; Dioxanes; Growth Hormone; Idazoxan; Kinetics; Male; Rats; Receptors, Adrenergic, alpha; Reserpine; Yohimbine | 1986 |
The effects of alpha 2 adrenoceptor agonists on airway pressure in anaesthetized sheep.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Airway Resistance; Animals; Clonidine; Dioxanes; Female; Histamine; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Methoxamine; Prazosin; Pyrilamine; Sheep; Tripelennamine; Xylazine | 1986 |
Pharmacological properties of the enantiomers of idazoxan: possible separation between their alpha-adrenoceptor blocking effects.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Cerebral Cortex; Chickens; Clonidine; Decerebrate State; Dioxanes; Dioxins; Dogs; Electric Stimulation; Female; Heart Rate; Hypnotics and Sedatives; Idazoxan; Isomerism; Male; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Synapses; Tachycardia | 1986 |
Unmasking of the inhibitory action of glucose on insulin release after alpha 2-adrenergic activation.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Cells, Cultured; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Glucose; Idazoxan; Insulin; Islets of Langerhans; Mice; Mice, Obese | 1986 |
Possible involvement of presynaptic alpha 1-adrenoceptors in the effects of idazoxan and prazosin on 3H-noradrenaline release from tail arteries of SHR.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Dioxins; Electric Stimulation; Idazoxan; Male; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: the nucleus reticularis lateralis.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cats; Clonidine; Dioxanes; Female; Idazoxan; Isoquinolines; Male; Medulla Oblongata; Piperazines; Prazosin; Yohimbine | 1987 |
Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; Kindling, Neurologic; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1987 |
Noradrenergic effects on rat visual cortex: single-cell microiontophoretic studies of alpha-2 adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; Male; Neurons; Norepinephrine; Oxymetazoline; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Visual Cortex | 1987 |
Tight agonist binding may prevent the correct interpretation of agonist competition binding curves for alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cell Membrane; Clonidine; Dioxanes; Epinephrine; Idazoxan; Kinetics; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Retina | 1987 |
Possible role of alpha-2-noradrenergic receptors in modulation of sexual behavior in female guinea pigs.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Estradiol; Female; Guinea Pigs; Idazoxan; Methoxamine; Ovariectomy; Phenylephrine; Posture; Progesterone; Receptors, Adrenergic, alpha; Sexual Behavior, Animal; Yohimbine | 1987 |
Effects of the alpha 2-adrenergic agonist clonidine and its antagonist idazoxan on the fetal lamb.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Brain; Brain Stem; Carotid Sinus; Clonidine; Dioxanes; Dioxins; Female; Fetus; Hemodynamics; Idazoxan; Pregnancy; Respiration; Sheep; Vagus Nerve | 1986 |
Antinociceptive actions of intravenous alpha 2-adrenoceptor agonists in sheep.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Female; Hot Temperature; Idazoxan; Injections, Intravenous; Nociceptors; Pressure; Sheep; Thiazines; Xylazine | 1987 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Release of i-r metenkephalin from rat amygdala slices in vitro.
Topics: Adrenergic beta-Antagonists; Amygdala; Animals; Calcium; Clonidine; Dioxanes; Enkephalin, Methionine; Idazoxan; In Vitro Techniques; Male; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Further evidence of noradrenergic regulation of rat hypothalamic estrogen receptor concentration: possible non-functional increase and functional decrease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Cytosol; Dioxanes; Female; Hypothalamus; Idazoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Estrogen; Yohimbine | 1987 |
Alpha 2-adrenergic receptors in brown adipose tissue of infant rats--I. Identification and characteristics of binding sites in isolated plasma membranes.
Topics: Adipose Tissue, Brown; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Membrane; Clonidine; Dihydroalprenolol; Dioxanes; Idazoxan; Kinetics; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1988 |
Analgesic effects of intrathecally-applied alpha 2-adrenoceptor agonists in conscious, unrestrained sheep.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Idazoxan; Injections, Spinal; Sheep; Time Factors; Xylazine | 1988 |
Electrophysiological evidence for alpha 1- and alpha 2-adrenoceptors in solitary tract nucleus.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Epinephrine; Idazoxan; Male; Medulla Oblongata; Methoxamine; Neurons; Norepinephrine; Prazosin; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex | 1988 |
Presynaptic alpha 2-adrenoceptors mediate inhibition of cholinergic transmission in rabbit vesical parasympathetic ganglia.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Epinephrine; Ganglia, Parasympathetic; Idazoxan; Rabbits; Receptors, Adrenergic, alpha; Urinary Bladder; Yohimbine | 1987 |
Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Electrophysiology; Evoked Potentials; Idazoxan; Locus Coeruleus; Neural Inhibition; Pertussis Toxin; Virulence Factors, Bordetella | 1988 |
Alpha-adrenoceptor occupancy by N,N-dimethyl-2-bromo-2-phenethylamine hydrobromide (DMPEA) in rat vas deferens.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenethylamines; Rats; Receptors, Adrenergic, alpha; Thiosulfates; Vas Deferens | 1988 |
Effect of clonidine on ultrasonic vocalization in preweaning rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Body Temperature; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Hot Temperature; Idazoxan; Prazosin; Rats; Rats, Inbred Strains; Reference Values; Ultrasonics; Vocalization, Animal | 1988 |
Dipropylacetate-induced shaking behaviour in the rat: a role of spinal alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Idazoxan; Injections, Intraventricular; Male; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Valproic Acid | 1988 |
Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Decerebrate State; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Electric Stimulation; Female; Idazoxan; Male; Naloxone; Norepinephrine; Rabbits; Reflex; Sural Nerve | 1988 |
Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Cats; Clonidine; Dioxanes; Heart Rate; Idazoxan; Male; Naphthalenes; Neurons; Pyrimidines; Receptors, Serotonin; Sympathetic Nervous System; Tetrahydronaphthalenes; Trimethaphan; Vagotomy | 1987 |
Long-term amitriptyline treatment alters the affinity state of alpha 2 adrenoceptors in rabbit hindbrain.
Topics: Amitriptyline; Animals; Blood Pressure; Body Weight; Brain Stem; Cerebellum; Clonidine; Dioxanes; Epinephrine; Heart Rate; Idazoxan; Male; Rabbits; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Corpus Striatum; Dioxanes; Idazoxan; Piperazines; Pyrimidines; Rats; Receptors, Adrenergic, alpha; Spiperone; Structure-Activity Relationship | 1986 |
Activation of alpha 2-adrenoreceptors enhances haloperidol-induced suppression of operant behavior.
Topics: Animals; Behavior, Animal; Brain Chemistry; Clonidine; Conditioning, Operant; Dihydroxyphenylalanine; Dioxanes; Drug Interactions; Haloperidol; Idazoxan; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Evidence for the involvement of presynaptic alpha-2 adrenoceptors in the regulation of norepinephrine metabolism in the rat brain.
Topics: Animals; Brain; Clonidine; Dioxanes; Electric Stimulation; Ibotenic Acid; Idazoxan; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetrodotoxin; Tissue Distribution | 1987 |
The release of catecholamines from the adrenal medulla and its modulation by alpha 2-adrenoceptors in the anaesthetized dog.
Topics: Adrenal Medulla; Animals; Catecholamines; Clonidine; Dioxanes; Dogs; Dopamine; Electric Stimulation; Epinephrine; Female; Idazoxan; Male; Norepinephrine; Oxymetazoline; Receptors, Adrenergic, alpha; Splanchnic Nerves; Yohimbine | 1987 |
Idazoxan blocks the action of noradrenaline but not spinal inhibition from electrical stimulation of the locus coeruleus and nucleus Kolliker-Fuse of the cat.
Topics: Action Potentials; Animals; Cats; Clonidine; Dioxanes; Dioxins; Electric Stimulation; Idazoxan; Locus Coeruleus; Neural Inhibition; Neurons, Afferent; Norepinephrine; Pain; Physical Stimulation; Spinal Cord | 1988 |
Ventrolateral medullary pressor area: site of hypotensive action of clonidine.
Topics: Animals; Blood Pressure; Clonidine; Dioxanes; Heart Rate; Hypotension; Idazoxan; Male; Medulla Oblongata; Muscimol; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity | 1987 |
Pre- and postsynaptic a-adrenoceptor blockade by (imidazolinyl-2)-2-benzodioxane 1-4 (170 150): antagonistic action on the central effects of clonidine.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cerebral Ventricles; Chickens; Clonidine; Dioxanes; Dioxins; Dogs; Electric Stimulation; Female; Heart Rate; Hemodynamics; Idazoxan; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Peripheral alpha 1- and alpha 2-adrenoreceptor mechanisms in blood pressure control.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Blood Pressure; Clonidine; Dioxins; Guanabenz; Idazoxan; Male; Muscle, Smooth, Vascular; Norepinephrine; Phenoxybenzamine; Phentolamine; Prazosin; Pressoreceptors; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Synapses; Vascular Resistance | 1983 |
In vitro studies with (imidazolinyl-2)-2-benzodioxane-1-4 ((+/-)-170 150), a new potent alpha 2-adrenoceptor blocking agent.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Clonidine; Dioxins; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine | 1982 |
Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxins; Dose-Response Relationship, Drug; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tyramine; Vas Deferens; Vasoconstriction; Yohimbine | 1983 |
RX781094, a new potent alpha 2 adrenoceptor antagonist. In vivo and in vitro studies in the rabbit.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain; Clonidine; Dioxins; Dose-Response Relationship, Drug; Drug Interactions; Guanabenz; Heart Rate; Idazoxan; Male; Rabbits | 1983 |
Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cerebral Cortex; Clonidine; Dioxins; Drug Antagonism; Electroencephalography; Guanabenz; Idazoxan; Male; Parietal Lobe; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Sleep; Wakefulness | 1983 |
Effect of 781094, a new selective alpha-adrenoceptor antagonist, on the aggregatory responses of human blood platelets and on binding of [3H]-dihydroergocryptine to these cells.
Topics: Adrenergic alpha-Antagonists; Blood Platelets; Brimonidine Tartrate; Clonidine; Dihydroergotoxine; Dioxins; Epinephrine; Humans; Idazoxan; Methoxamine; Platelet Aggregation; Quinoxalines; Serotonin; Tritium | 1983 |
A study of the selectivity and potency of rauwolscine, RX 781094 and RS 21361 as antagonists of alpha-1 and alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxins; Dose-Response Relationship, Drug; Heart Rate; Hypnotics and Sedatives; Idazoxan; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine | 1984 |
Evidence for a peripheral component in the sympatholytic effect of clonidine in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dioxanes; Dioxins; Epinephrine; Growth Hormone; Heart Rate; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Inbred Strains; Sympatholytics; Time Factors | 1984 |
Comparative effects of RX 781094, mianserin, yohimbine, rauwolscine and prazosin in reversing clonidine inhibition of MIX-stimulated lipolysis in hamster isolated white fat cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Clonidine; Cricetinae; Dioxanes; Epididymis; Idazoxan; In Vitro Techniques; Lipolysis; Male; Mianserin; Prazosin; Theophylline; Yohimbine | 1984 |
Action of stereoisomers of (imidazolinyl-2)-2-benzodioxane-1-4 or 2-(2-(1,4-benzodioxanyl))-2-imidazoline (170 150; RX 781094) on peripheral presynaptic and central alpha 2-adrenoceptors.
Topics: Animals; Brain; Chickens; Clonidine; Dioxins; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peripheral Nerves; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Sleep; Stereoisomerism; Vas Deferens | 1982 |
Lack of involvement of alpha 2-adrenoceptors in the regulation of striatal dopaminergic transmission.
Topics: Acetylcholine; Animals; Clonidine; Corpus Striatum; Dioxins; Dopamine; Idazoxan; Male; Piperoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Dopamine; Yohimbine | 1983 |
Alpha-2 adrenergic receptors on neurones in the region of the lateral reticular nucleus of the rat.
Topics: Animals; Clonidine; Dioxins; Evoked Potentials; gamma-Aminobutyric Acid; Humans; Idazoxan; Medulla Oblongata; Neurons; Norepinephrine; Prazosin; Rats; Receptors, Adrenergic; Reticular Formation; Synaptic Transmission | 1983 |
Brain 3,4-dihydroxyphenylethyleneglycol levels are dependent on central noradrenergic neuron activity.
Topics: Animals; Brain; Cerebral Cortex; Clonidine; Dioxins; Electric Stimulation; Glycols; Hippocampus; Idazoxan; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Inbred Strains; Tetrodotoxin; Yohimbine | 1982 |
Receptor binding and functional evidence suggest that postsynaptic alpha 2-adrenoceptors in rat brain are of the alpha 2D subtype.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzylamines; Binding Sites; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Dopamine; Idazoxan; Male; Mydriasis; Neurons; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin; Zimeldine | 1995 |
Molecular characterization and isolation of a 45-kilodalton imidazoline receptor protein from the rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electrophoresis; Idazoxan; Imidazoles; Imidazoline Receptors; Immunoblotting; Male; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1995 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against alpha 2-adrenoceptor mediation.
Topics: Animals; Anxiety; Behavior, Animal; Clonidine; Dioxanes; Genotype; Idazoxan; Imidazoles; Mice; Mice, Inbred Strains; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Cold Temperature; Dioxanes; Disease Models, Animal; Hot Temperature; Idazoxan; Injections, Intravenous; Male; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Stress, Mechanical | 1995 |
A pharmacokinetic-pharmacodynamic linking model for the alpha 2-adrenergic antagonism of idazoxan on clonidine-induced mydriasis in the rat.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Chromatography, High Pressure Liquid; Clonidine; Computer Simulation; Dioxanes; Disease Models, Animal; Dose-Response Relationship, Drug; Half-Life; Idazoxan; Injections, Intravenous; Male; Models, Chemical; Mydriasis; Pupil; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1995 |
Imidazoline binding sites on PC12 cells and bovine chromaffin cells.
Topics: Adrenal Medulla; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cattle; Cell Membrane; Chromaffin Granules; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Mitochondria; PC12 Cells; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Signal Transduction | 1995 |
Alpha 2 adrenoceptor- and imidazoline-preferring binding sites in the dog kidney.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Dioxanes; Dogs; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Male; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 1995 |
In vivo modulation of norepinephrine and glutamate release through imidazoline receptors in the rat central nervous system.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Central Nervous System; Clonidine; Dioxanes; Glutamic Acid; Idazoxan; Imidazoline Receptors; Norepinephrine; Quinolines; Rats; Receptors, Drug | 1995 |
Spinal imidazoline receptors do not mediate the antinociceptive action of intrathecal clonidine in the rat.
Topics: Analgesics; Animals; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Spinal; Radioligand Assay; Rats; Receptors, Drug; Spinal Cord | 1995 |
Human cerebral imidazoline binding sites. Further biochemical investigations.
Topics: Animals; Brain; Cattle; Clonidine; Dioxanes; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Receptors, Drug | 1995 |
Heterogeneity of imidazoline binding sites revealed by a cirazoline derivative.
Topics: Animals; Binding Sites; Brain; Clonidine; Dioxanes; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Rabbits; Receptors, Drug; Species Specificity | 1994 |
Effects of alpha-adrenoceptor agonists and antagonists on metabolic rate in cattle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basal Metabolism; Body Temperature; Brimonidine Tartrate; Cattle; Clonidine; Dioxanes; Female; Guanfacine; Heart Rate; Idazoxan; Male; Prazosin; Quinoxalines | 1995 |
Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clonidine; Desipramine; Dioxanes; Dopamine; Dopamine Uptake Inhibitors; Electroshock; Extracellular Space; Idazoxan; Male; Microdialysis; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1995 |
Spinal nonadrenergic imidazoline receptors do not mediate the antinociceptive action of intrathecal clonidine in the rat.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Binding, Competitive; Clonidine; Dioxanes; Idazoxan; Imidazoline Receptors; Injections, Spinal; Male; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Spinal Cord; Yohimbine | 1995 |
Attenuation of arteriolar alpha 2-adrenoceptor sensitivity during endotoxemia.
Topics: Animals; Arterioles; Clonidine; Dioxanes; Endotoxins; Escherichia coli; Idazoxan; Male; Muscles; Phenylephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Shock, Septic; Vasoconstriction | 1994 |
Characterization of binding sites for [3H]-idazoxan, [3H]-P-aminoclonidine and [3H]-rauwolscine in the kidney of the dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Clonidine; Dioxanes; Dogs; GTP-Binding Proteins; Idazoxan; Imidazoline Receptors; Kidney; Male; Radioligand Assay; Receptors, Drug; Yohimbine | 1994 |
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels; Animals; Benzofurans; Binding, Competitive; Clonidine; Clorgyline; Diazoxide; Dioxanes; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulinoma; Ligands; Pancreatic Neoplasms; Potassium Channels; Rats; Receptors, Drug; Regression Analysis; Software; Tumor Cells, Cultured | 1994 |
Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues.
Topics: Adrenal Medulla; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain Chemistry; Chromatography, Affinity; Clonidine; Dioxanes; Electrophoresis, Polyacrylamide Gel; Humans; Idazoxan; Imidazoline Receptors; Immunoblotting; Liver; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tritium | 1994 |
Effects of alpha-2 adrenoceptor antagonists on rough-and-tumble play in juvenile rats: evidence for a site of action independent of non-adrenoceptor imidazoline binding sites.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Agonistic Behavior; Animals; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Interpersonal Relations; Male; Prazosin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Drug | 1994 |
Evidence for altered alpha 2-adrenoceptor function following isolation-rearing in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cyclic AMP; Dioxanes; Hippocampus; Idazoxan; Male; Motor Activity; Prefrontal Cortex; Pupil; Rats; Receptors, Adrenergic, alpha-2; Social Isolation; Stereotyped Behavior | 1994 |
Alpha 1A-adrenoceptor subtype mediates contraction of the rat urethra.
Topics: Aminoquinolines; Animals; Calcium; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines; Urethra | 1994 |
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Clonidine; Dihydroxyphenylalanine; Dioxanes; Idazoxan; Injections, Subcutaneous; Male; Mydriasis; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reserpine; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Effect of the centrally acting muscle relaxant tizanidine on spinal reflexes: involvement of descending noradrenergic systems.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Decerebrate State; Dioxanes; Hexamethonium Compounds; Idazoxan; Male; Muscle Relaxants, Central; Norepinephrine; Phentolamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reflex; Reflex, Monosynaptic; Spinal Cord; Sympathetic Nervous System | 1993 |
Alpha 2-adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral medulla.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Evoked Potentials; gamma-Aminobutyric Acid; Idazoxan; Injections, Intravenous; Iontophoresis; Male; Medulla Oblongata; Neurons; Nordefrin; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Yohimbine | 1993 |
Down-regulation of imidazoline sites in rabbit kidney.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Down-Regulation; Guanabenz; Idazoxan; Imidazoline Receptors; Kidney; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1993 |
(-)-2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0923), a selective D2 dopamine receptor agonist demonstrates the presence of D2 dopamine receptors in the mouse vas deferens but not in the rat vas deferens.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Dopamine Agents; Idazoxan; Male; Mice; Rats; Receptors, Dopamine D2; Species Specificity; Sulpiride; Tetrahydronaphthalenes; Thiophenes; Vas Deferens | 1993 |
Suppressed renal response to 2,6-dimethyl clonidine but not clonidine in one kidney-one clip hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Clonidine; Dioxanes; Disease Models, Animal; Hypertension, Renovascular; Idazoxan; Kidney; Male; Natriuresis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Drug; Tritium; Yohimbine | 1993 |
Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Animals; Behavior, Animal; Clonidine; Dioxanes; Electrophysiology; Hot Temperature; Idazoxan; Macaca fascicularis; Macaca mulatta; Male; Medulla Oblongata; Microinjections; Naloxone; Norepinephrine; Pain; Physical Stimulation; Receptors, Opioid | 1993 |
Prejunctional alpha 2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Trachea; Yohimbine | 1993 |
The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clonidine; Conflict, Psychological; Dioxanes; Drinking Behavior; GABA Antagonists; Idazoxan; Infusions, Intravenous; Male; Piperoxan; Rats; Rats, Sprague-Dawley; Yohimbine | 1994 |
Infusions of alpha-2 noradrenergic agonists and antagonists into the amygdala: effects on kindling.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amygdala; Animals; Benzazepines; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Functional Laterality; Idazoxan; Infusions, Parenteral; Kindling, Neurologic; Male; Rats; Receptors, Adrenergic, alpha-2; Seizures; Xylazine; Yohimbine | 1993 |
Differential receptors involved in the cardiovascular effects of clonidine and rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Male; Methyldopa; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1993 |
In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Diazoxide; Dioxanes; Electrophysiology; Female; Glucose; Idazoxan; In Vitro Techniques; Indoles; Insulin; Islets of Langerhans; Mice; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Tolbutamide | 1994 |
Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Brain Chemistry; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Dioxanes; Female; GTP-Binding Proteins; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1994 |
Effects of long-term alpha-2 adrenergic antagonists and electroconvulsive treatments on the alpha-2 adrenoceptors modulating serotonin neurotransmission.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Clonidine; Dioxanes; Electroconvulsive Therapy; Idazoxan; Male; Mianserin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin; Synaptic Transmission | 1994 |
Clonidine enhances astrocytic glutamine uptake by authentic alpha 2-adrenoceptor stimulation.
Topics: Adrenergic alpha-Agonists; Animals; Astrocytes; Cells, Cultured; Clonidine; Dioxanes; Glutamine; Idazoxan; Mice; Receptors, Adrenergic, alpha; Serotonin; Structure-Activity Relationship; Yohimbine | 1994 |
The alpha 2-agonist clonidine suppresses seizures, whereas the alpha 2-antagonist idazoxan promotes seizures--a microinfusion study in amygdala-kindled kittens.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Amygdala; Animals; Anticonvulsants; Cats; Clonidine; Convulsants; Dioxanes; Electrodes, Implanted; Electrophysiology; Epilepsy, Tonic-Clonic; Female; Idazoxan; Kindling, Neurologic; Male; Microinjections; Seizures | 1994 |
Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipramine; Male; Mice; Pargyline; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic; Reserpine; Seizures; Strychnine | 1994 |
Effects of neonatal exposure to clonidine on basal and activated central noradrenaline metabolism and in vivo overflow.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Clonidine; Dialysis; Dioxanes; Idazoxan; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Weight Gain; Yohimbine | 1994 |
Role of vascular alpha-1 adrenoceptor subtypes in the pressor response to sympathetic nerve stimulation in the pithed rat.
Topics: Animals; Blood Pressure; Blood Vessels; Clonidine; Decerebrate State; Dioxanes; Electric Stimulation; Idazoxan; Male; Nifedipine; Piperazines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 1994 |
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
Topics: 3T3 Cells; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Clone Cells; Clonidine; Cyclic AMP; Dioxanes; Humans; Idazoxan; Kinetics; Male; Mice; Pertussis Toxin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1994 |
Blockade of alpha 2-adrenoceptors stimulates basal and stress-induced adrenocorticotropin secretion in the developing rat through a central mechanism independent from corticotropin-releasing factor and arginine vasopressin.
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Arginine Vasopressin; Brain; Catecholamines; Clonidine; Corticosterone; Corticotropin-Releasing Hormone; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; In Vitro Techniques; Locus Coeruleus; Lypressin; Pituitary Gland; Rats; Rats, Sprague-Dawley; Reference Values; Stress, Physiological | 1994 |
Characterization of imidazoline binding protein(s) solubilized from human brainstem: studies with [3H]idazoxan and [3H]clonidine.
Topics: Binding Sites; Cell Membrane; Cholic Acids; Chromatography, Gel; Clonidine; Dioxanes; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Norepinephrine; Receptors, Drug; Solubility; Tritium; Yohimbine | 1994 |
Involvement of imidazoline-preferring receptors in regulation of sympathetic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine | 1994 |
The effect of alpha 2-adrenoceptor antagonists in isolated globally ischemic rat hearts.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Coronary Circulation; Dioxanes; Heart; Heart Rate; Idazoxan; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardium; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Tolazoline; Ventricular Pressure; Yohimbine | 1994 |
Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha 2-adrenoceptors in the human central nervous system.
Topics: Aged; Aged, 80 and over; Autoradiography; Binding Sites; Brain; Cell Membrane; Clonidine; Dioxanes; Female; Humans; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Kinetics; Male; Middle Aged; Organ Specificity; Pituitary Gland; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug; Spinal Cord | 1994 |
Alpha-adrenergic and muscarinic cholinergic inhibition of ACh release in guinea pig trachea: role of neuronal K+ channels.
Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Clonidine; Dioxanes; Electrochemistry; Guinea Pigs; Idazoxan; Male; Neurons; Parasympathomimetics; Peptides; Potassium Channel Blockers; Potassium Channels; Sympathomimetics; Trachea | 1994 |
Modulation by central postsynaptic alpha 2-adrenoceptors of the jaw-opening reflex induced by orofacial stimulation in rats.
Topics: Amphetamine; Animals; Brain; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; Jaw; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Reserpine | 1994 |
Anxiogenic-like effects of yohimbine and idazoxan in two behavioral situations in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Anxiety; Behavior, Animal; Choice Behavior; Clonidine; Conditioning, Classical; Conflict, Psychological; Dioxanes; Flumazenil; Idazoxan; Male; Mice; Yohimbine | 1993 |
Effects of clonidine, dexmedetomidine and xylazine on thermal antinociception in rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Azocines; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Rate; Hot Temperature; Idazoxan; Imidazoles; Macaca mulatta; Male; Medetomidine; Muscle Relaxation; Pain Threshold; Respiration; Xylazine | 1993 |
[3H]p-aminoclonidine and [3H]idazoxan label different populations of imidazoline sites on rat kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Dioxanes; Guanosine Triphosphate; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isoquinolines; Kidney; Male; Naphazoline; Naphthyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tritium | 1993 |
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Epinephrine; Heart Rate; Hyperglycemia; Idazoxan; Indoles; Male; Mice; Motor Activity; Norepinephrine; Peripheral Nerves; Prazosin; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasoconstriction | 1993 |
Presynaptic alterations associated with enhancement of evoked release and synthesis of norepinephrine in hippocampus of chronically cold-stressed rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Clonidine; Cold Temperature; Dialysis; Dioxanes; Extracellular Space; Hippocampus; Idazoxan; Male; Norepinephrine; Potassium; Rats; Rats, Sprague-Dawley; Stress, Physiological; Synapses | 1993 |
Involvement of alpha 2-receptors in the analgesia induced by transient forebrain ischemia in rats.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain; Carotid Artery, Common; Clonidine; Dioxanes; Endorphins; Idazoxan; Ischemic Attack, Transient; Male; Methysergide; Naloxone; Norepinephrine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Yohimbine | 1993 |
Inhibitory effects of clonidine on serotonergic neuronal activity as measured by cerebrospinal fluid serotonin and its metabolite in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Animals; Central Nervous System; Chromatography, High Pressure Liquid; Clonidine; Dioxanes; Idazoxan; Male; Oxidopamine; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists | 1993 |
Species-selective binding of [3H]-idazoxan to alpha 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Central Nervous System; Cerebral Cortex; Clonidine; Dioxanes; GTP-Binding Proteins; Guanosine Triphosphate; Guinea Pigs; Humans; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Kinetics; Membranes; Mice; Quinuclidinyl Benzilate; Rats; Receptors, Adrenergic, alpha; Receptors, Drug; Species Specificity; Yohimbine | 1993 |
Acute and chronic effects of cholinesterase inhibitors and pilocarpine on the density and sensitivity of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Cholinesterase Inhibitors; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Isoflurophate; Male; Neostigmine; Physostigmine; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Clonidine; Dioxanes; Electroencephalography; Hippocampus; Idazoxan; Infusions, Parenteral; Locus Coeruleus; Male; Neurons; Rats; Rats, Sprague-Dawley | 1993 |
Clonidine-induced place preference is mediated by alpha 2-adrenoceptors outside the locus coeruleus.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Clonidine; Conditioning, Psychological; Dextroamphetamine; Dioxanes; Drug Interactions; Idazoxan; Injections, Intraperitoneal; Locus Coeruleus; Male; Oxidopamine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1993 |
Interactions between the effects of opioid, serotonin and alpha-2-adrenergic receptor agonists on growth hormone release in the male rat. Intrahypothalamic administration.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dioxanes; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Growth Hormone; Hypothalamus; Idazoxan; Injections; Male; Quipazine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Serotonin | 1993 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Droxidopa; Drug Synergism; Idazoxan; Imipramine; Male; Methyltyrosines; Mice; Norepinephrine; Pargyline; Phentolamine; Physostigmine; Prazosin; Reserpine; Seizures; Serotonin | 1993 |
Nonadrenergic imidazoline binding sites on human platelets.
Topics: Affinity Labels; Binding Sites; Binding, Competitive; Blood Platelets; Cell Membrane; Clonidine; Dioxanes; Humans; Idazoxan; Imidazoline Receptors; Iodine Radioisotopes; Kinetics; Norepinephrine; Receptors, Adrenergic, alpha-2; Receptors, Drug; Tritium | 1993 |
Automated method for the measurement of fentanyl-induced muscular rigidity.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Fentanyl; Idazoxan; Male; Muscle Rigidity; Physiology; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1993 |
No effect of genetic obesity and mazindol on imidazoline I2 binding sites in the brain of Zucker rats.
Topics: Animals; Binding Sites; Brain Chemistry; Clonidine; Dioxanes; Idazoxan; Imidazoline Receptors; Male; Mazindol; Obesity; Rats; Rats, Zucker; Receptors, Adrenergic, alpha; Receptors, Drug | 1993 |
Heterogeneity of the specific imidazoline binding of [3H]idazoxan in the human cerebral cortex.
Topics: Binding Sites; Brain Stem; Cell Membrane; Cerebral Cortex; Clonidine; Dioxanes; Frontal Lobe; Guanylyl Imidodiphosphate; Humans; Idazoxan; Imidazoles; Kinetics; Magnesium Chloride; Tritium; Yohimbine | 1993 |
The prejunctional inhibitory effect of alpha-methylnoradrenaline in the rat vas deferens is not mediated via alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Clonidine; Dioxanes; Electric Stimulation; Idazoxan; Imidazoles; Isometric Contraction; Male; Neuromuscular Junction; Nordefrin; Phenoxybenzamine; Phentolamine; Quinolines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Adrenergic, alpha-2; Vas Deferens; Vasoconstrictor Agents; Yohimbine | 1995 |
Expression of I2-imidazoline sites in rat prostate. Effect of castration and aging.
Topics: Adrenergic Agonists; Aging; Animals; Binding, Competitive; Cell Membrane; Clonidine; Dioxanes; Gene Expression Regulation; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Male; Orchiectomy; Prostate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Drug; Testosterone; Tritium | 1996 |
Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Blood Pressure; Bradycardia; Clonidine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Female; Glycopyrrolate; Heart Rate; Hemodynamics; Idazoxan; Imidazoles; Injections, Spinal; Male; Parasympatholytics; Reaction Time; Sympatholytics; Vagus Nerve; Vasoconstrictor Agents; Wakefulness; Yohimbine | 1996 |
A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Chlordiazepoxide; Clonidine; Dioxanes; Diphenhydramine; Hypnotics and Sedatives; Idazoxan; Imidazoles; Injections, Subcutaneous; Isoquinolines; Male; Maze Learning; Mydriasis; Naphthyridines; Picrotoxin; Rats; Rats, Sprague-Dawley; Yohimbine | 1995 |
Selectivity of rilmenidine for I1-imidazoline-binding sites in rabbit proximal tubule cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney Tubules, Proximal; Kinetics; Male; Oxazoles; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Tritium | 1995 |
Alpha 2 noradrenoceptors in the anterior piriform cortex decline with acute amino acid deficiency.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acids; Animals; Anorexia; Brain; Cerebral Cortex; Clonidine; Cyclic AMP; Dioxanes; Feeding Behavior; Hypothalamus; Idazoxan; Imidazoles; Male; Norepinephrine; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1996 |
5-hydroxytryptaminergic receptor-mediated regulation of growth hormone secretion in Holstein steers occurs via alpha 2-adrenergic-dependent and -independent mechanisms.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Clonidine; Cyproheptadine; Dioxanes; Growth Hormone; Growth Hormone-Releasing Hormone; Idazoxan; Imidazoles; In Vitro Techniques; Male; Pituitary Gland, Anterior; Quipazine; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine | 1996 |
The alpha 2-adrenoreceptor agonist clonidine suppresses seizures, whereas the alpha 2-adrenoreceptor antagonist idazoxan promotes seizures in amygdala-kindled kittens: a comparison of amygdala and pontine microinfusion effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amygdala; Animals; Cats; Clonidine; Dioxanes; Disease Susceptibility; Electrodes, Implanted; Epilepsy; Female; Functional Laterality; Idazoxan; Imidazoles; Kindling, Neurologic; Locus Coeruleus; Male; Microinjections; Norepinephrine; Seizures; Stereotaxic Techniques | 1996 |
Polyclonal anti-idiotypic antibodies to idazoxan and their interaction with human brain imidazoline binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antibodies, Anti-Idiotypic; Antibody Specificity; Brain; Clonidine; Humans; Idazoxan; Rabbits; Receptors, Drug | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Altered thermoregulatory responses to clonidine in streptozotocin-diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature Regulation; Clonidine; Diabetes Mellitus, Experimental; Idazoxan; Male; Rats; Rats, Wistar; Streptozocin; Time Factors; Yohimbine | 1996 |
Antinociceptive effects of oral clonidine and S12813-4 in acute colon inflammation in rats.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Colitis; Female; Formaldehyde; Idazoxan; Oxazoles; Rats; Rats, Sprague-Dawley; Yohimbine | 1996 |
Changes in noradrenergic sensitivity to tumor necrosis factor-alpha in brains of rats administered clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Autoreceptors; Clonidine; Electric Stimulation; Gene Expression Regulation; Hippocampus; Idazoxan; Male; Nerve Endings; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tumor Necrosis Factor-alpha | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
Clonidine, but not morphine, delays the development of thermal hyperesthesia induced by sciatic nerve constriction injury in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; Hyperesthesia; Idazoxan; Ligation; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Sciatic Nerve; Spinal Cord; Sympathetic Nervous System; Temperature; Time Factors | 1996 |
The alpha 2 adrenoreceptor agonist clonidine suppresses seizures, whereas the alpha 2 adrenoreceptor antagonist idazoxan promotes seizures: pontine microinfusion studies of amygdala-kindled kittens.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Amygdala; Animals; Cats; Clonidine; Electric Stimulation; Idazoxan; Kindling, Neurologic; Microelectrodes; Microinjections; Norepinephrine; Pons; Seizures; Sympatholytics | 1996 |
Effects of clonidine, yohimbine and idazoxan on isolated carotid arteries of dog.
Topics: Animals; Carotid Arteries; Clonidine; Dogs; Idazoxan; In Vitro Techniques; Muscle, Smooth, Vascular; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine | 1996 |
Effects of clonidine on a C-fibre reflex in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Analysis of Variance; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Idazoxan; Male; Nerve Fibers; Nociceptors; Rats; Rats, Sprague-Dawley; Reflex | 1996 |
Synergistic behavioral interaction between ethanol and clonidine in rats: role of alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Blood Pressure; Clonidine; Drug Synergism; Ethanol; Idazoxan; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Reflex; Yohimbine | 1996 |
Identification and characterization of imidazoline-binding sites from calf striatum.
Topics: Animals; Binding, Competitive; Cattle; Clonidine; Corpus Striatum; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Receptors, Drug | 1996 |
Receptor-mediated effects of clonidine on need-induced 3% NaCl and water intake.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Drinking; Idazoxan; Male; Rats; Receptors, Adrenergic; Sodium Chloride | 1997 |
Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Guanabenz; Idazoxan; Imidazoles; Male; Microdialysis; Piperoxan; Prefrontal Cortex; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley | 1997 |
Social isolation in the rat enhances alpha 2-autoreceptor function in the hippocampus in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Dentate Gyrus; Idazoxan; Male; Microdialysis; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha-2; Social Isolation; Stress, Physiological | 1997 |
Effect of isolation-rearing on noradrenaline release in rat hypothalamus and hippocampus in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animal Husbandry; Animals; Calcium; Clonidine; Hippocampus; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Social Isolation | 1997 |
Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites.
Topics: Affinity Labels; Animals; Binding Sites; Cattle; Cell Fractionation; Cell Membrane; Clonidine; Guanine Nucleotides; Guanylyl Imidodiphosphate; Idazoxan; Imidazoline Receptors; Medulla Oblongata; Receptors, Drug; Tritium | 1997 |
Pharmacological characterization of I1 and I2 imidazoline receptors in human striatum.
Topics: Adrenergic alpha-Antagonists; Aged; Allosteric Regulation; Clonidine; Corpus Striatum; Female; Humans; Idazoxan; Imidazoline Receptors; Male; Middle Aged; Receptors, Drug; Structure-Activity Relationship | 1997 |
An antiserum to idazoxan recognizes an immunoreactive substance in human serum and cerebral spinal fluid which is not agmatine.
Topics: Agmatine; Animals; Antibody Specificity; Antigens; Cattle; Clonidine; Humans; Idazoxan; Imidazoline Receptors; Immune Sera; Radioimmunoassay; Rats; Receptors, Drug; Serum Albumin, Bovine | 1997 |
Binding of new cirazoline derivative to imidazoline receptors from human brain.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Brain; Clonidine; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Mitochondria; Photochemistry; Rabbits; Rats; Receptors, Drug; Tritium; Ultraviolet Rays; Yohimbine | 1997 |
Effects of moxonidine and clonidine on renal function and blood pressure in anesthetized rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Glomerular Filtration Rate; Idazoxan; Imidazoles; Kidney; Male; Plasma Volume; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium; Water-Electrolyte Balance; Yohimbine | 1997 |
Further biochemical characterization of imidazoline binding sites from the human brainstem.
Topics: Adrenergic alpha-Antagonists; Binding Sites; Brain Stem; Chromatography, Affinity; Clonidine; Enzyme Inhibitors; Humans; Idazoxan; Imidazoles; Receptors, Drug | 1997 |
The novel alpha 2-adrenoceptor agonist [3H]mivazerol binds to non-adrenergic binding sites in human striatum membranes that are distinct from imidazoline receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Aged; Clonidine; Corpus Striatum; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Membranes; Middle Aged; Radioligand Assay; Receptors, Drug; Tritium | 1997 |
Antagonism of clonidine injected intracerebroventricularly in different models of salt intake.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dehydration; Diet, Sodium-Restricted; Idazoxan; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary | 1996 |
Idazoxan and the effect of intracerebroventricular oxytocin or vasopressin on sodium intake of sodium-depleted rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arginine Vasopressin; Behavior, Animal; Clonidine; Idazoxan; Injections, Intraventricular; Male; Oxytocin; Rats; Receptors, Adrenergic, alpha-2; Sodium; Sodium, Dietary | 1997 |
Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Clonidine; Idazoxan; Imidazoles; Magnesium; Male; Manganese; Medetomidine; Membranes; Radioligand Assay; Rats; Reproducibility of Results; Retina; Sensitivity and Specificity; Tritium | 1997 |
Involvement of supraspinal GABA receptors in majonoside-R2 suppression of clonidine-induced antinociception in mice.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Flumazenil; GABA Antagonists; GABA Modulators; Ginsenosides; Idazoxan; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Pain Measurement; Picrotoxin; Receptors, GABA-A; Saponins; Spinal Cord | 1997 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic | 1997 |
The influence of chronic treatment with clonidine, yohimbine and idazoxan on morphine withdrawal.
Topics: Adrenergic Agents; Animals; Clonidine; Drug Interactions; Idazoxan; Male; Mice; Morphine; Narcotics; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome; Yohimbine | 1997 |
The role of alpha-2 adrenoceptors in the regulation of oxytocin neurones in the suckled rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Suckling; Clonidine; Dose-Response Relationship, Drug; Electrophysiology; Female; Idazoxan; Lactation; Neurons; Oxytocin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Supraoptic Nucleus | 1997 |
Regulation of growth hormone-releasing hormone and somatostatin from perifused, bovine hypothalamic slices. I. Alpha 2-adrenergic receptor regulation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Clonidine; Growth Hormone-Releasing Hormone; Guanabenz; Homeostasis; Hypothalamus; Idazoxan; In Vitro Techniques; Potassium Chloride; Receptors, Adrenergic, alpha-2; Somatostatin | 1997 |
Renal and blood pressure effects of moxonidine and clonidine in spontaneously hypertensive rats.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Aminoacridines; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypertension; Idazoxan; Imidazoles; Kidney; Male; Phenformin; Rats; Rats, Inbred SHR; Sodium; Urodynamics; Yohimbine | 1997 |
Catecholamine activation in the vasomotor center on emergence from anesthesia: the effects of alpha2 agonists.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anesthesia; Animals; Catecholamines; Clonidine; Idazoxan; Imidazoles; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Vasomotor System | 1998 |
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding, Competitive; Brain Chemistry; Brimonidine Tartrate; Cell Membrane; Clonidine; Depression; Female; Frontal Lobe; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Suicide; Tritium | 1998 |
Clonidine reduces dopamine and increases GABA in the nucleus accumbens: an in vivo microdialysis study.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dopamine; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Idazoxan; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1998 |
Selective potentiation by ouabain of naloxone-induced withdrawal contractions of isolated guinea-pig ileum following acute exposure to morphine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Idazoxan; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Ouabain; Receptors, Adrenergic, alpha-2; Sodium-Potassium-Exchanging ATPase; Substance Withdrawal Syndrome | 1998 |
Antagonist precipitated clonidine withdrawal in rat: effects on locus coeruleus neurons, sympathetic nerves and cardiovascular parameters.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular System; Clonidine; Consciousness; Halothane; Heart Rate; Idazoxan; Imidazoles; Locus Coeruleus; Male; Neurons; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Substance Withdrawal Syndrome; Sympathetic Nervous System; Sympatholytics; Vascular Resistance | 1998 |
alpha2-adrenoceptors modulate NMDA-evoked responses of neurons in superficial and deeper dorsal horn of the medulla.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Evoked Potentials; Idazoxan; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1998 |
Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Clonidine; Excitatory Amino Acids; Hot Temperature; Idazoxan; Iontophoresis; Male; Methoxamine; Neural Inhibition; Neurons; Norepinephrine; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spinal Cord; Synapses | 1998 |
Alpha 2-adrenoceptor activation may trigger the increased production of endothelium-derived nitric oxide in skeletal muscle during acute haemorrhage.
Topics: Acute Disease; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Epinephrine; Hemorrhage; Idazoxan; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Receptors, Adrenergic, alpha-2; Regional Blood Flow; Vasodilation | 1998 |
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1999 |
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Rabbits; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Regression Analysis; Solubility; Static Electricity; Structure-Activity Relationship | 1998 |
Differential effects of the noradrenergic agonist clonidine on the locomotion of intact, partially and completely spinalized adult cats.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Denervation; Electromyography; Idazoxan; Locomotion; Motor Neurons; Norepinephrine; Radioligand Assay; Spinal Cord; Spinal Cord Injuries; Tritium | 1998 |
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Central noradrenergic mediation of nitrous oxide-induced analgesia in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Drug Synergism; Idazoxan; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurons, Afferent; Nitrous Oxide; Rats; Rats, Wistar; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Receptors, Presynaptic; Spinal Cord; Synaptic Transmission | 1998 |
Inhibition of stress-stimulated colonic propulsion by alpha 2-adrenoceptor antagonists in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Clonidine; Colon; Defecation; Gastrointestinal Motility; Gastrointestinal Transit; Idazoxan; Male; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Stress, Physiological; Yohimbine | 1998 |
Heterogeneous characteristics of imidazoline-induced insulin secretion.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium; Clonidine; Drug Interactions; Enzyme Inhibitors; Glucose; Idazoxan; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Phentolamine; Potassium Channels; Time Factors | 1999 |
Clonidine evokes vasodepressor responses via alpha2-adrenergic receptors in gigantocellular reticular formation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Idazoxan; Male; Medulla Oblongata; Microinjections; Neurons; Prazosin; Rats; Rats, Sprague-Dawley; Reticular Formation | 1999 |
Adrenergic sensitivity of the sensory receptors modulating mechanical allodynia in a rat neuropathic pain model.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Causalgia; Clonidine; Idazoxan; Male; Neurons, Afferent; Norepinephrine; Phenylephrine; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Nerves; Sympathectomy; Sympathetic Nervous System; Yohimbine | 1999 |
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Humans; Idazoxan; Isoquinolines; Neuroblastoma; Oxymetazoline; Piperazines; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Yohimbine | 1999 |
Coexpression of imidazoline receptors and alpha 2-adrenoceptors in neuroglial cell line NG 108,15.
Topics: Animals; Binding, Competitive; Cell Membrane; Clonidine; Glioma; Hybrid Cells; Idazoxan; Imidazoline Receptors; Kinetics; Neuroblastoma; Neuroglia; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 1999 |
Identification of human I1 receptors and their relationship to alpha 2-adrenoceptors.
Topics: Animals; Binding Sites; Brain; Cattle; Clonidine; Humans; Idazoxan; Imidazoline Receptors; Kinetics; Organ Specificity; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug | 1999 |
Identification of I1 and I2 imidazoline receptors in striatum membranes from different species.
Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Clonidine; Corpus Striatum; Dogs; Haplorhini; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Mice; Rabbits; Rats; Receptors, Drug; Species Specificity; Tritium | 1999 |
Imidazoline (I2) binding sites in chicken brain.
Topics: Agmatine; Amiloride; Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Chickens; Clonidine; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Receptors, Drug; Tritium | 1999 |
Importance of imidazoline receptors in the cardiovascular responses of clonidine in sinoaortic denervated rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Clonidine; Denervation; Heart Rate; Heart Valves; Idazoxan; Imidazoline Receptors; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, Drug; Sinus of Valsalva; Yohimbine | 1999 |
Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Brimonidine Tartrate; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Dendritic Cells; Drug Interactions; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Time Factors | 1999 |
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Stimulation; Female; Heart Atria; Heart Rate; Idazoxan; Imidazoles; In Vitro Techniques; Muscle Contraction; Norepinephrine; Pargyline; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors | 1999 |
Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Clonidine; Cognition; Diazepam; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Idazoxan; Macaca mulatta; Memory; Reaction Time; Receptors, Adrenergic, alpha-2; Reserpine; Space Perception | 1999 |
Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Clonidine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Space; Frontal Lobe; Hippocampus; Idazoxan; Male; Microdialysis; Morpholines; Norepinephrine; Rats; Rats, Sprague-Dawley; Reboxetine; Serotonin; Sodium Chloride; Time Factors | 1999 |
Oxytocin enhances the effects of clonidine on blood pressure and locomotor activity in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Blood Pressure; Clonidine; Drug Synergism; Heart Rate; Idazoxan; Injections, Intraventricular; Locomotion; Locus Coeruleus; Male; Motor Activity; Oxytocin; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 1999 |
Antagonistic effect of N-methyltyramine on alpha2-adrenoceptor in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Idazoxan; Male; Mice; Radioligand Assay; Receptors, Adrenergic, alpha-2; Scopolamine; Tyramine | 1999 |
Inhibitory effects of NPY on ganglionic transmission in myenteric neurones of the guinea-pig descending colon.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Colon; Excitatory Postsynaptic Potentials; Ganglia, Sympathetic; Guinea Pigs; Idazoxan; Male; Motor Neurons; Myenteric Plexus; Neural Inhibition; Neuropeptide Y; Norepinephrine; Pancreatic Polypeptide; Peptide Fragments; Presynaptic Terminals; Propranolol | 2000 |
Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Chronic Disease; Clonidine; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Hyperalgesia; Idazoxan; Male; Neuronal Plasticity; Pain, Intractable; Perceptual Disorders; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Tumor Necrosis Factor-alpha | 2000 |
Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Antipsychotic Agents; Clonidine; Clozapine; Depression; Dose-Response Relationship, Drug; Electric Stimulation; Idazoxan; Male; Rats; Risperidone; Self Stimulation; Tegmentum Mesencephali | 1999 |
Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Idazoxan; Imidazoles; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Spectrophotometry, Infrared; Yohimbine | 2000 |
Norepinephrine release from spinal synaptosomes: auto-alpha2 -adrenergic receptor modulation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blotting, Western; Clonidine; Idazoxan; Male; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptosomes; Transfection; Yohimbine | 2000 |
Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; CHO Cells; Clonidine; Cloning, Molecular; COS Cells; Cricetinae; DNA, Complementary; Epinephrine; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Immune Sera; Iodine Radioisotopes; Molecular Sequence Data; Naphazoline; Receptors, Drug; Ruthenium Red; Sequence Tagged Sites; Staining and Labeling; Transfection; Yohimbine | 2000 |
A further characterization of alpha-2 adrenoceptor involvement in the rough-and-tumble play of juvenile rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Idazoxan; Male; Norepinephrine; Play and Playthings; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2000 |
Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Calcium; CHO Cells; Clonidine; Cricetinae; DNA, Recombinant; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Idazoxan; Kinetics; Medetomidine; Mice; Oxymetazoline; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Transfection | 2000 |
Diabetes attenuates the response of the lumbospinal noradrenergic system to idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Body Weight; Clonidine; Diabetes Mellitus, Experimental; Gene Expression Regulation; Idazoxan; Male; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Messenger; Spinal Cord; Tritium | 2000 |
Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Clonidine; Desipramine; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Idazoxan; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium | 2001 |
Morphine and clonidine activate different K+ channels on rat amygdala neurons.
Topics: Adrenergic alpha-Antagonists; Amygdala; Analgesics; Animals; Clonidine; Idazoxan; Membrane Potentials; Morphine; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats | 2001 |
Differential effects of clonidine, dopamine, dobutamine, and dopexamine on basal and acid-stimulated mucosal blood flow in the rat stomach.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Blood Flow Velocity; Blood Pressure; Cardiotonic Agents; Clonidine; Dobutamine; Dopamine; Dopamine Agonists; Drug Evaluation, Preclinical; Female; Gastric Acid; Heart Rate; Idazoxan; Infusions, Intravenous; Intestinal Mucosa; Microcirculation; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2001 |
Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Gene Expression Regulation; GTP-Binding Proteins; Idazoxan; Male; Membranes; Norepinephrine; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reserpine; RNA, Messenger; Tritium | 2001 |
Imidazolines inhibit secretory responses of rat colonic mucosa to calcium-dependent but not cyclic AMP-dependent secretagogues.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Colon; Cyclic AMP; Idazoxan; Imidazoles; In Vitro Techniques; Intestinal Mucosa; Male; Phentolamine; Rats; Rats, Wistar | 2001 |
Alpha2A-adrenoceptor mediated tachypnea in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Goats; Guanfacine; Heart Rate; Idazoxan; Periodicity; Receptors, Adrenergic, alpha-2; Respiratory Mechanics | 2001 |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Catheterization; Clonidine; Drug Interactions; Ethanol; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex.
Topics: 4-Butyrolactone; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cerebellum; Clonidine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Extracellular Space; Haloperidol; Idazoxan; Male; Microdialysis; Motor Cortex; Neurons; Norepinephrine; Prefrontal Cortex; Quinpirole; Rats; Rats, Sprague-Dawley; Solvents | 2001 |
Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Animals; Binding, Competitive; Brimonidine Tartrate; Cerebral Arteries; Clonidine; Dose-Response Relationship, Drug; Female; Fetus; Idazoxan; Middle Cerebral Artery; Norepinephrine; Phenylephrine; Pregnancy; Quinoxalines; Receptors, Adrenergic, alpha-2; Sheep; Tetrodotoxin; Vasoconstriction; Vasoconstrictor Agents; Yohimbine | 2002 |
Role of histamine H3 receptors in control of mouse intestinal motility in vivo and in vitro: comparison with alpha2-adrenoceptors.
Topics: Animals; Charcoal; Clonidine; Histamine Agonists; Histamine Antagonists; Idazoxan; Ileum; Imidazoles; In Vitro Techniques; Male; Methylhistamines; Mice; Peristalsis; Piperidines; Receptors, Adrenergic, alpha-2; Receptors, Histamine H3 | 2002 |
Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Clonidine; Electrophysiology; Idazoxan; Male; Morpholines; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Intrathecal clonidine decreases spinal nitric oxide release in a rat model of complete Freund's adjuvant induced inflammatory pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Enzyme Inhibitors; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Spinal; Male; Myelitis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Effects of medullary alpha2-adrenoceptor blockade in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Kidney; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Solitary Nucleus; Sympathetic Nervous System | 2002 |
Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake.
Topics: Amphetamines; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cerebellar Nuclei; Clonidine; Diuretics; Drinking; Drinking Behavior; Furosemide; Idazoxan; Imidazoline Receptors; Injections, Intraventricular; Male; Methysergide; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride, Dietary | 2002 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Azepines; Brimonidine Tartrate; Clonidine; Idazoxan; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxazoles; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Yohimbine | 2002 |
Dual effect of agmatine in the bisected rat vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Epididymis; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Potassium Chloride; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Yohimbine | 2003 |
Role of I1-imidazoline receptors within the caudal ventrolateral medulla in cardiovascular responses to clonidine in rats.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Heart Rate; Idazoxan; Imidazoline Receptors; Injections, Intravenous; Male; Medulla Oblongata; Microelectrodes; Microinjections; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Drug; Yohimbine | 2003 |
Alpha2-adrenoceptor antagonism is neither sufficient nor necessary for the distinctive action of atypical neuroleptics on intracranial self-stimulation in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Clonidine; Haloperidol; Idazoxan; Male; Motivation; Olanzapine; Pirenzepine; Rats; Receptors, Adrenergic, alpha-2; Self Stimulation | 2003 |
Modulation of theta rhythmicity in the medial septal neurons and the hippocampal electroencephalogram in the awake rabbit via actions at noradrenergic alpha2-receptors.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Administration Routes; Hippocampus; Idazoxan; Male; Neurons; Rabbits; Receptors, Adrenergic, alpha-2; Septal Nuclei; Septum of Brain; Theta Rhythm; Time Factors; Wakefulness | 2003 |
Identification and characterization of the imidazoline I2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors.
Topics: Adipose Tissue, Brown; Amiloride; Animals; Binding Sites; Binding, Competitive; Cell Line, Tumor; Clonidine; Culture Techniques; Dose-Response Relationship, Drug; Guanabenz; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Liver; Mammary Neoplasms, Animal; Mice; Protein Binding; Rats; Receptors, Drug; Species Specificity; Yohimbine | 2003 |
Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Autonomic Dysreflexia; Chronic Disease; Clonidine; Electric Stimulation; Female; Idazoxan; In Vitro Techniques; Phenylephrine; Potassium; Prazosin; Rats; Rats, Wistar; Spinal Cord Injuries; Tail; Vasoconstriction | 2004 |
Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Arousal; Auditory Perception; Clonidine; Dose-Response Relationship, Drug; Finches; Guanabenz; Idazoxan; Imidazoles; Isoproterenol; Male; Norepinephrine; Oxathiins; Phenylephrine; Propanolamines; Prosencephalon; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Vocalization, Animal; Yohimbine | 2004 |
Clonidine increases caspase-3 mRNA level and DNA fragmentation in the developing rat brainstem.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Brain Stem; Caspase 3; Caspases; Cell Differentiation; Clonidine; DNA Fragmentation; Female; Idazoxan; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Messenger; Up-Regulation | 2004 |
Cardiovascular effects of agmatine within the rostral ventrolateral medulla are similar to those of clonidine in anesthetized rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Anesthesia; Animals; Baroreflex; Blood Pressure; Cardiovascular Physiological Phenomena; Clonidine; Efferent Pathways; Glutamic Acid; Heart Rate; Idazoxan; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sympathetic Nervous System | 2005 |
Opposite changes in imidazoline I2 receptors and alpha2-adrenoceptors density in rat frontal cortex after induced gliosis.
Topics: Actins; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blotting, Western; Cell Membrane; Clonidine; Epinephrine; Glial Fibrillary Acidic Protein; Gliosis; Hot Temperature; Idazoxan; Imidazoline Receptors; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2005 |
Characterisation of imidazoline I2 binding sites in pig brain.
Topics: Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Carbolines; Clonidine; Dose-Response Relationship, Drug; Female; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Male; Monoamine Oxidase Inhibitors; Picolinic Acids; Radioligand Assay; Receptors, Drug; Swine; Thiazoles; Tritium | 2005 |
Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amides; Animals; Arteries; Clonidine; Electric Stimulation; Electrophysiology; Female; Idazoxan; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Phenylephrine; Prazosin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Suramin; Tail; Vasoconstriction | 2005 |
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Muscle Relaxants, Central; Norepinephrine; Oxidopamine; Rats; Rats, Wistar; Receptors, Drug; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Spinal Cord; Sympathetic Nervous System; Time Factors | 2005 |
Long-lasting effects of yohimbine on the ejaculatory function in male dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Ejaculation; Idazoxan; Male; Penile Erection; Sexual Behavior, Animal; Time Factors; Yohimbine | 2005 |
Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Base Sequence; Brain; Clonidine; DNA Primers; Idazoxan; Mice; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Polymerase Chain Reaction; Receptors, Adrenergic, alpha-2; RNA, Messenger | 2006 |
Alpha-noradrenergic receptors modulate the development and expression of cocaine sensitization.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Cocaine; Idazoxan; Male; Motor Activity; Prazosin; Rats; Rats, Sprague-Dawley; Time Factors; Yohimbine | 2006 |
The alpha2 adrenoreceptor agonist clonidine suppresses evoked and spontaneous seizures, whereas the alpha2 adrenoreceptor antagonist idazoxan promotes seizures in amygdala-kindled kittens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amygdala; Animals; Animals, Newborn; Cats; Clonidine; Electroencephalography; Female; Functional Laterality; Idazoxan; Kindling, Neurologic; Male; Microinjections; Seizures; Stereotaxic Techniques | 2007 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |
Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Anticonvulsants; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gabapentin; gamma-Aminobutyric Acid; Idazoxan; Neuralgia; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord | 2008 |
Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Area Under Curve; Clonidine; Dansyl Compounds; Disease Models, Animal; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors; Yohimbine | 2009 |
Locus coeruleus stimulation and noradrenergic modulation of hippocampo-prefrontal cortex long-term potentiation.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Benzylamines; Clonidine; Dopamine; Hippocampus; Idazoxan; Locus Coeruleus; Long-Term Potentiation; Male; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin | 2010 |
α2-adrenergic drugs modulate the binding of [18F]fallypride to dopamine D2/3 receptors in striatum of living mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzamides; Binding, Competitive; Brain Mapping; Clonidine; Corpus Striatum; Dopamine; Female; Idazoxan; Mice; Mice, Inbred BALB C; Positron-Emission Tomography; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Yohimbine | 2010 |
Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptors.
Topics: Agmatine; Animals; Arginine; Biguanides; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Enzyme Inhibitors; Guanidines; Idazoxan; Male; Mice; Motor Activity; Nicotine; Receptors, Adrenergic, alpha-2; Yohimbine | 2010 |
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Chromones; Clonidine; Excitatory Postsynaptic Potentials; Female; Idazoxan; Models, Animal; Motor Neurons; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Sensory Receptor Cells; Spasm; Spinal Cord Injuries; Synaptic Transmission | 2011 |
Study of adrenergic, imidazoline, and endothelin receptors in clonidine-, morphine-, and oxycodone-induced changes in rat body temperature.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Body Temperature; Body Temperature Regulation; Brain; Clonidine; Dansyl Compounds; Drug Synergism; Endothelin A Receptor Antagonists; Idazoxan; Imidazoline Receptors; Male; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Yohimbine | 2011 |
Effects of clonidine and idazoxan on tetrathiomolybdate-induced copper and lysosomal enzyme excretion into sheep bile.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Bile; Clonidine; Copper; Female; Gene Expression Regulation, Enzymologic; Glucuronidase; Idazoxan; Lysosomes; Molybdenum; Sheep | 2012 |
Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Clonidine; Cochlear Nucleus; Drug Interactions; Humans; Idazoxan; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Mice; Mice, Transgenic; Neural Inhibition; Norepinephrine; Propranolol; Synapses; Synaptic Transmission; Time Factors | 2011 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord | 2012 |
The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α(2) adrenergic mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antiparkinson Agents; Benserazide; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyskinesia, Drug-Induced; Dystonia; Facial Asymmetry; Idazoxan; Levodopa; Locomotion; Oxidopamine; Parkinson Disease; Piribedil; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Statistics, Nonparametric; Upper Extremity | 2013 |
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Idazoxan; Male; Methoxamine; Movement; Neurons; Norepinephrine; Nucleus Accumbens; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2012 |
α2 Adrenergic receptor-mediated inhibition of thermogenesis.
Topics: Adipose Tissue, Brown; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Electromyography; Idazoxan; Medulla Oblongata; Neural Pathways; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Shivering; Sympathetic Nervous System; Thermogenesis | 2013 |
Removal of half the sympathetic innervation does not reduce vasoconstrictor responses in rat tail artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Desipramine; Idazoxan; Isometric Contraction; Muscle Denervation; Myocytes, Smooth Muscle; Neuromuscular Junction; Norepinephrine; Phenylephrine; Rats; Sympathetic Nervous System; Synaptic Potentials; Tail; Vasoconstriction | 2013 |
Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test.
Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Benzofurans; Biguanides; Bupropion; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Guanidines; Idazoxan; Imidazoles; Immobility Response, Tonic; Injections, Intraventricular; Male; Mice; Motor Activity | 2013 |
Selective modulation of lymphoproliferation and cytokine production via intracellular signaling targets by α1- and α2-adrenoceptors and estrogen in splenocytes.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Cyclic AMP Response Element-Binding Protein; Estradiol; Estrogens; Extracellular Signal-Regulated MAP Kinases; Idazoxan; Interferon-gamma; Interleukin-2; Male; NF-kappa B; Phenylephrine; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spleen; T-Lymphocytes | 2013 |
Investigation of the role of alpha-2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Idazoxan; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Reflex, Acoustic; Reflex, Startle; Sensory Gating | 2016 |
Activation of beta- and alpha-2-adrenoceptors in the basolateral amygdala has opposing effects on hippocampal-prefrontal long-term potentiation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Basolateral Nuclear Complex; Clonidine; Hippocampus; Idazoxan; Isoproterenol; Long-Term Potentiation; Male; Norepinephrine; Prefrontal Cortex; Propranolol; Rats; Rats, Sprague-Dawley | 2017 |
Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Pressure Determination; Clonidine; Consciousness; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 2019 |