clonidine and hydrochlorothiazide

clonidine has been researched along with hydrochlorothiazide in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	55 (67.07)	18.7374
1990's	9 (10.98)	18.2507
2000's	9 (10.98)	29.6817
2010's	9 (10.98)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chan, PS; Emma, JE; Meyer, WE; Tomcufcik, AS	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dixon, GT; Johnson, ES	1
Rodman, MJ	1
Distler, A; Kirch, W	1
Kontro, J; Kyöstilä, S; Mattila, MJ; Pitkäjärvi, T	1
Brym, E; Sznajderman, M; Wolyńczyk-Niegowska, J	1
Bardhan, AK; Basu, J; Chakrabarty, K; Chhetri, MK; Das, S; Ghosh, JC; Maity, AK; Majumder, G; Neelakantan, C	1
Hlede, M; Palatini, P; Pessina, AC; Pigato, R	1
Pettinger, WA	1
Pavlov, AA; Rykin, BA	1
Babaian, AS; Dzhandzhapanian, AZ; Gurgenian, SV; Mikaelian, ES	1
Chen, L; Rouch, AJ; Schafer, JA; Troutman, SL	1
Elliott, WJ; Fumo, MT; Gramelspacher, GP; Gretler, DD; Murphy, MB	1
Liepinja, DJ; Rudzite, VK; Silava, AK; Vitols, AV	1
Liepinia, DJ; Skarda, IJ; Skards, JV; Vitols, AV; Voita, DU	1
Ferder, L; Inserra, F; Medina, F	1
Borreson, RE; Fisher, SG; Freis, ED; Hamburger, R; Mezey, KC; Mukherji, B; Neal, WW; Perry, HM; Taguchi, JT; Thomas, JR	1
Goodfriend, TL; Schmidt, GR; Schuna, AA	1
Al'khimovich, VM; Gaĭduk, VN; Nechesova, TA; Pavlova, AI; Sidorenko, GI	1
Baumgart, P; Greminger, P; Groth, H; Knüsel, J; Siegenthaler, W; Vetter, H; Vetter, W	1
Schmidt, GR; Schuna, AA	1
Felton, K; Hui, TP; Krakoff, LR; Yeager, K	1
Cubeddu, LX; Davila, S; Escontrelas, C; Hoffmann, IS; Morales, C; Rios, A	1
Dhasmana, KM; Fokker, WA; Spilker, BA	1
Lung-Johansen, P	1
Davidov, M; Finnerty, FA; Mroczek, WJ	1
Halawa, B	1
Richter, R	1
Panikarskiĭ, VG	3
Chernow, B; Coleman, MD; Lake, CR; Zaloga, GP; Ziegler, MG	1
Carver, LA; Lee, CH; Strosberg, AM	1
Alexander, N; Maronde, RF; Velasquez, M; Vlachakis, ND	1
Farsang, C; Fekete, M; Kapocsi, J; Kunos, G; Malisak, Z; Vajda, L; Varga, K	1
Drayer, JI; Weber, MA	1
Moyer, JH	1
Hamilton, BP; Hamilton, J; Kuzbida, G; Levinson, P; Mersey, JH; Pavlis, R	1
Falkner, B; Koffler, S; Lowenthal, DT	1
Baumgart, P; Boerlin, HJ; Groth, H; Knüsel, J; Siegenthaler, W; Vetter, H; Vetter, W; Walger, P; Wehling, M	2
Tsikulin, AE; Volkov, VS	1
Avramenko, TV; Zborovskiĭ, EI	1
Lopez, LM; Mehta, JL	1
Eninia, GI; Godlevska, MA; Smeltere, ES; Uzulinia, IP	1
Beitman, RE; Kuzma, RJ; McMahon, FG; Morledge, J; Mroczek, W; Rolf, CN; Tsai, TH	1
Bauer, P; Dorcsi, M; Hitzenberger, G; Korn, A; Wohlzogen, FX	1
Affrime, MB; Falkner, B; Lowenthal, DT; Onesti, G	2
Affrime, MB; Falkner, B; Hamstra, B; Lowenthal, DT	1
Artman, M; Boerth, RC	1
Graf, E	1
Fontaine, R; Friehe, H; Gibson, JP; Larson, EJ; Sells, DM	1
Aigner, A; Schmidt, U	1
Distler, A; Kirch, W; Lüth, B	1
Kaplan, HR; Smith, RD; Tessman, DK	1
Dustan, HP; Oparil, S; Smith, LR; Wilkins, LH; Winternitz, SR	1
Deitch, MW; Hare, LE; Walker, BR	1
Lochaya, S; Suvachittanont, O; Thongmitr, V	1
Cybulska, I; Wasowska-Ciszek, T	1
Dal Palù, C; Hlede, M; Palatini, P; Pessina, AC; Pigato, R	1
Cushman, WC; Freis, ED; Fye, C; Gottdiener, J; Hamburger, RJ; Kochar, MS; Lakshman, R; Massie, BM; Materson, BJ; Reda, DJ	1
Anderson, RJ; Gottdiener, JS; Massie, BM; Materson, BJ; Reda, DJ; Williams, DW	1
Cushman, WC; Freis, ED; Lakshman, MR; Materson, BJ; Reda, DJ	1
Cushman, WC; Materson, BJ; Reda, DJ; Williams, DW	1
Chen, J; Chen, S; Chen, Y; Lu, X; Shen, C; Tang, J; Wang, H; Wang, L; Wang, W; Wang, X; Yang, S; Zhao, X; Zhao, Y; Zhou, W	1
Cheng, YQ; Lin, LL; Liu, AJ; Su, DF; Wang, D; Wang, W	1
Wang, Y; Xu, B; Zhu, H	1

Reviews

4 review(s) available for clonidine and hydrochlorothiazide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug therapy: clonidine, a new antihypertensive drug. The New England journal of medicine, 1975, Dec-04, Volume: 293, Issue:23 Topics: Blood Pressure; Brain; Clonidine; Drug Interactions; Drug Therapy, Combination; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Hypoglycemic Agents; Kidney; Minoxidil; Propranolol; Substance Withdrawal Syndrome; Sympathetic Nervous System; Tolazoline	1975
[Current treatment of hypertension]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1980, Apr-01, Volume: 33, Issue:8 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Methyldopa; Phthalazines; Reserpine	1980
Drug systems approach to hypertension. Pennsylvania medicine, 1984, Volume: 87, Issue:5 Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Hypertension, Malignant; Methyldopa; Patient Compliance; Prazosin; Proteinuria; Renin-Angiotensin System; Reserpine; Spironolactone	1984

Trials

23 trial(s) available for clonidine and hydrochlorothiazide

Article	Year
Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine. International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:3 Topics: Adolescent; Adult; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Phenoxybenzamine; Phenylacetates; Triamterene	1978
Antihypertensive drug combinations: prazosin, hydrochlorothiazide and clonidine. Annals of clinical research, 1977, Volume: 9, Issue:5 Topics: Blood Pressure Determination; Clinical Trials as Topic; Clonidine; Drug Combinations; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Posture; Prazosin; Quinazolines; Time Factors	1977
Influence of diuretic therapy on the clonidine suppression test. Journal of clinical pharmacology, 1991, Volume: 31, Issue:5 Topics: Adult; Amiloride; Clonidine; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Male; Norepinephrine; Premedication	1991
Effects of reduction in drugs or dosage after long-term control of systemic hypertension. The American journal of cardiology, 1989, Mar-15, Volume: 63, Issue:11 Topics: Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Drug Administration Schedule; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Propranolol; Random Allocation; Reserpine; Time Factors	1989
Effects of propranolol, clonidine and hydrochlorothiazide treatment and abrupt discontinuation on central and peripheral noradrenergic activity in essential hypertension. Life sciences, 1986, Dec-22, Volume: 39, Issue:25 Topics: Adrenergic Fibers; Adult; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Drug Administration Schedule; Female; Humans; Hydrochlorothiazide; Male; Propranolol; Renin; Time Factors	1986
Haemodynamic changes in long-term therapy of essential hypertension: a comparative study of diuretics, alpha-methyldopa and clonidine. Clinical science and molecular medicine. Supplement, 1973, Volume: 45 Suppl 1 Topics: Adult; Cardiac Output; Chlorthalidone; Clinical Trials as Topic; Clonidine; Diuretics; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Polythiazide; Vascular Resistance	1973
Hemodynamic effect of lofexidine with a diuretic in hypertension. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:6 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Epinephrine; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Isometric Contraction; Male; Middle Aged; Norepinephrine	1983
Reversal by naloxone of the antihypertensive action of clonidine: involvement of the sympathetic nervous system. Circulation, 1984, Volume: 69, Issue:3 Topics: Adult; Blood Pressure; Clonidine; Drug Therapy, Combination; Epinephrine; Heart Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Naloxone; Norepinephrine; Renin; Stroke Volume; Sympathetic Nervous System	1984
Clinical experience with rate-controlled delivery of antihypertensive therapy by a transdermal system. American heart journal, 1984, Volume: 108, Issue:1 Topics: Administration, Oral; Blood Pressure; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Skin Absorption	1984
Effects of antihypertensive drugs on cognitive function in adolescents. Pediatric pharmacology (New York, N.Y.), 1984, Volume: 4, Issue:4 Topics: Adolescent; Antihypertensive Agents; Clonidine; Cognition; Female; Humans; Hydrochlorothiazide; Hypertension; Male	1984
Comparative efficacy and safety of lofexidine and clonidine given alone or concomitantly with hydrochlorothiazide in hypertensive outpatients. Arzneimittel-Forschung, 1982, Volume: 32, Issue:8a Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1982
[Controlled randomized double-blind study for the comparison of the treatment of patients with essential hypertension with homeopathic and with pharmacologically effective drugs]. Wiener klinische Wochenschrift, 1982, Dec-24, Volume: 94, Issue:24 Topics: Amiloride; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Combinations; Female; Homeopathy; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pindolol; Pulse; Random Allocation	1982
The use of clonidine monotherapy in adolescent hypertension. Chest, 1983, Volume: 83, Issue:2 Suppl Topics: Adolescent; Adult; Blood Pressure; Clonidine; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Random Allocation; Stress, Psychological	1983
R-wave amplitude change during aerobic exercise in hypertensive adolescents after treatment. The American journal of cardiology, 1983, Volume: 51, Issue:3 Topics: Adolescent; Adult; Aerobiosis; Blood Pressure; Clonidine; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male	1983
Lofexidine, a new, antihypertensive imidazoline derivative. Clinical profile of action with single-drug treatment and in combination with hydrochlorothiazide. Arzneimittel-Forschung, 1982, Volume: 32, Issue:8a Topics: Antihypertensive Agents; Blood Chemical Analysis; Blood Pressure; Clonidine; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1982
Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Epinephrine; Female; Guanfacine; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Phenoxybenzamine; Phenylacetates; Triamterene	1980
Lofexidine and clonidine in moderate essential hypertension. Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:6 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Posture; Random Allocation	1981
Comparative antihypertensive effects of guanabenz and clonidine. The Journal of international medical research, 1982, Volume: 10, Issue:1 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Guanabenz; Guanidines; Humans; Hydrochlorothiazide; Male; Middle Aged; Pulse; Sleep Stages	1982
Effectiveness of centrally acting drugs and diuretics in adolescent hypertension. Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:5 Topics: Adolescent; Blood Pressure; Clonidine; Double-Blind Method; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Random Allocation	1982
Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. The New England journal of medicine, 1993, Apr-01, Volume: 328, Issue:13 Topics: Age Factors; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Captopril; Clonidine; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin	1993
Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Circulation, 1997, Apr-15, Volume: 95, Issue:8 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Captopril; Clonidine; Cohort Studies; Diltiazem; Diuretics; Double-Blind Method; Echocardiography; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardium; Organ Size; Prazosin; Prevalence; Risk Factors; Sodium Chloride Symporter Inhibitors; Treatment Outcome; United States; United States Department of Veterans Affairs	1997
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Archives of internal medicine, 1999, Mar-22, Volume: 159, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Captopril; Clonidine; Diltiazem; Diuretics; Double-Blind Method; Hospitals, Veterans; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins; Male; Middle Aged; Potassium; Prazosin; Time Factors; Treatment Outcome; United States	1999
Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:4 Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Clonidine; Diastole; Diltiazem; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin; Pressure; Pulse; Randomized Controlled Trials as Topic; Systole; Time Factors; Treatment Outcome	2001

Other Studies

55 other study(ies) available for clonidine and hydrochlorothiazide

Article	Year
N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as antihypertensive and diuretic agents. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Amidines; Animals; Antihypertensive Agents; Blood Pressure; Chemical Phenomena; Chemistry; Chlorobenzenes; Diuresis; Diuretics; Drug Evaluation, Preclinical; Hypertension; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Potassium; Rats; Rats, Inbred SHR; Sodium; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Efficacy of antihypertensive drugs. Lancet (London, England), 1976, Mar-06, Volume: 1, Issue:7958 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Indoramin; Methyldopa; Models, Biological; Posture	1976
Drug therapy today: how to cope with those new antihypertensive drugs. RN, 1979, Volume: 42, Issue:10 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Humans; Hydrochlorothiazide; Methyldopa; Propranolol	1979
[Evaluation of hypotensive effects of clonidine]. Kardiologia polska, 1977, Volume: 20, Issue:1 Topics: Adult; Blood Pressure; Clonidine; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1977
Antihypertensive and haemodynamic effects of clonidine-hydrochlorothiazide combination. Journal of the Indian Medical Association, 1977, May-01, Volume: 68, Issue:9 Topics: Adolescent; Adult; Clonidine; Drug Combinations; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1977
[Changes in kidney function during hypotensive treatment]. Bollettino della Societa italiana di cardiologia, 1976, Volume: 21, Issue:11 Topics: Adult; Aged; Clonidine; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Propranolol; Uremia	1976
[Side effects of long-term drug therapy of patients with uncomplicated arterial hypertension in a polyclinic]. Klinicheskaia meditsina, 1991, Volume: 69, Issue:8 Topics: Adolescent; Adult; Antihypertensive Agents; Cardiovascular Diseases; Clonidine; Dose-Response Relationship, Drug; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Propranolol; Time Factors	1991
Efficacy of intravenous verapamil in arterial hypertension refractory to three-step antihypertensive therapy. Cor et vasa, 1991, Volume: 33, Issue:5 Topics: Adult; Antihypertensive Agents; Clonidine; Echocardiography; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Infusions, Intravenous; Male; Methyldopa; Middle Aged; Nifedipine; Ventricular Function, Left; Verapamil	1991
Na+ transport in isolated rat CCD: effects of bradykinin, ANP, clonidine, and hydrochlorothiazide. The American journal of physiology, 1991, Volume: 260, Issue:1 Pt 2 Topics: Amiloride; Animals; Atrial Natriuretic Factor; Biological Transport; Bradykinin; Clonidine; Electric Conductivity; Hydrochlorothiazide; Kidney Tubules, Collecting; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Sodium; Sodium Channels	1991
Increased blood kynurenine level as a factor inhibiting the therapeutic effect of antihypertensive agents in combined long-term treatment of essential hypertension. Cor et vasa, 1990, Volume: 32, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Volume; Cardiomegaly; Clonidine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Kynurenine; Male; Middle Aged; Nifedipine; Propranolol; Tryptophan	1990
Haemodynamic resistance of forearm vessels during prolonged drug treatment of essential hypertension. Cor et vasa, 1990, Volume: 32, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Chlorthalidone; Clonidine; Drug Therapy, Combination; Forearm; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Propranolol; Vascular Resistance	1990
Safety aspects of long-term antihypertensive therapy (10 years) with clonidine. Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 12 Topics: Adult; Blood Pressure; Cardiomegaly; Cholesterol; Clonidine; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Triglycerides	1987
Transdermal clonidine compared with hydrochlorothiazide as monotherapy in elderly hypertensive males. Journal of clinical pharmacology, 1989, Volume: 29, Issue:2 Topics: Administration, Cutaneous; Aged; Blood Pressure; Clonidine; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Quality of Life	1989
[Optimization of hypotensive therapy in hospitals]. Kardiologiia, 1985, Volume: 25, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Cerebrovascular Circulation; Clonidine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Neuropsychological Tests; Reserpine	1985
[Transdermal clonidine: a new therapeutic approach in essential hypertension?]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1985, Mar-12, Volume: 74, Issue:11 Topics: Administration, Topical; Adult; Aged; Blood Pressure; Clonidine; Drug Eruptions; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Middle Aged	1985
Rebound hypertension after discontinuation of transdermal clonidine. Clinical pharmacy, 1988, Volume: 7, Issue:10 Topics: Administration, Cutaneous; Blood Pressure; Clonidine; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Substance Withdrawal Syndrome	1988
Diuretic treatment alters clonidine suppression of plasma norepinephrine. Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:4 Topics: Administration, Oral; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Clonidine; Drug Interactions; Epinephrine; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Norepinephrine; Potassium; Radioimmunoassay; Renin; Sodium	1986
Peripheral cardiovascular effects, in the pithed rat, of compounds used in the treatment of hypertension. British journal of pharmacology, 1972, Volume: 46, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cordotomy; Diazoxide; Electric Stimulation; Ergotamine; Guanethidine; Hydrochlorothiazide; Iproniazid; Male; Mecamylamine; Methyldopa; Pargyline; Phenobarbital; Rats; Reserpine; Sympathetic Nervous System; Thiocyanates; Trimethaphan	1972
Prolonged treatment with clonidine: comparative antihypertensive effects alone and with a diuretic agent. The American journal of cardiology, 1972, Volume: 30, Issue:5 Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clonidine; District of Columbia; Diuretics; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1972
[Antihypertensive therapy in pregnancy]. Der Gynakologe, 1982, Volume: 15, Issue:3 Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Clonidine; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Methyldopa; Pregnancy; Pregnancy Complications, Cardiovascular	1982
[Combined treatment of hypertension patients]. Vrachebnoe delo, 1984, Issue:10 Topics: Adolescent; Adult; Antihypertensive Agents; Clonidine; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Electroencephalography; Hexamethonium; Hexamethonium Compounds; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Quinuclidines; Triamterene	1984
Effect of antihypertensive therapy on sympathetic nervous system activity in patients with essential hypertension. Federation proceedings, 1984, Volume: 43, Issue:1 Topics: Antihypertensive Agents; Captopril; Clonidine; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Methyldopa; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reserpine; Sympathetic Nervous System; Vasodilator Agents	1984
Antihypertensive drugs: their postural hypotensive effect and their blood pressure lowering activity in conscious normotensive rats. Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 261, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Hydrochlorothiazide; Hypotension, Orthostatic; Male; Minoxidil; Nicardipine; Nifedipine; Nitroprusside; Pentolinium Tartrate; Phentolamine; Prazosin; Rats; Rats, Inbred Strains	1983
Withdrawal phenomena in subjects with essential hypertension on clonidine or tiamenidine. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5 Topics: Adult; Blood Pressure; Clonidine; Epinephrine; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Norepinephrine; Pulse; Random Allocation; Substance Withdrawal Syndrome; Thiophenes	1984
Clonidine through the skin in the treatment of essential hypertension: is it practical? Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1983, Volume: 1, Issue:2 Topics: Administration, Topical; Adult; Blood Pressure; Clonidine; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypersensitivity, Delayed; Hypertension; Male; Middle Aged	1983
[Mental changes in hypertensive patients during long-term ambulatory treatment]. Kardiologiia, 1983, Volume: 23, Issue:8 Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clonidine; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Mental Disorders; Middle Aged; MMPI; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors	1983
[Self-control of blood pressure for the purpose of increasing the effectiveness of ambulatory treatment of arterial hypertension]. Kardiologiia, 1983, Volume: 23, Issue:12 Topics: Adult; Ambulatory Care; Antihypertensive Agents; Blood Pressure; Clonidine; Diuretics; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Monitoring, Physiologic; Self Administration; Sodium Chloride Symporter Inhibitors; Time Factors	1983
[Clonidine transdermal therapeutic system in essential hypertension: effect and tolerance]. Schweizerische medizinische Wochenschrift, 1983, Dec-10, Volume: 113, Issue:49 Topics: Adult; Body Weight; Clonidine; Dermatitis, Contact; Drug Tolerance; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged	1983
Comparative efficacy and safety of lofexidine and clonidine in mild to moderately severe systemic hypertension. The American journal of cardiology, 1984, Mar-01, Volume: 53, Issue:6 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Random Allocation	1984
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension]. Klinicheskaia meditsina, 1984, Volume: 62, Issue:3 Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Clonidine; Drug Combinations; Drug Evaluation; Hemodynamics; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Intracranial Arteriosclerosis; Methyldopa; Middle Aged; Reserpine; Time Factors	1984
Clonidine poisoning. A complex problem. American journal of diseases of children (1960), 1983, Volume: 137, Issue:2 Topics: Apnea; Bradycardia; Child, Preschool; Clonidine; Dopamine; Female; Fluid Therapy; Gastric Lavage; Humans; Hydrochlorothiazide; Hypertension; Hypotension; Infant; Intubation, Intratracheal; Male; Sleep Stages; Tolazoline	1983
Actions of lofexidine on isolated heart and smooth muscle preparations. Arzneimittel-Forschung, 1982, Volume: 32, Issue:8a Topics: Animals; Clonidine; Drug Interactions; Guinea Pigs; Heart; Hydrochlorothiazide; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myocardial Contraction; Norepinephrine; Vas Deferens	1982
Toxicology of the combination lofexidine/hydrochlorothiazide. Arzneimittel-Forschung, 1982, Volume: 32, Issue:8a Topics: Animals; Clonidine; Dogs; Drug Combinations; Female; Hydrochlorothiazide; Male; Pregnancy; Rats; Rats, Inbred Strains; Teratogens	1982
Acute tolerance to prazosin in conscious hypertensive rats: involvement of the renin-angiotensin system. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:2 Topics: Angiotensin II; Animals; Captopril; Cardiovascular Agents; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Hydrochlorothiazide; Hypertension; Indomethacin; Male; Methyltyrosines; Prazosin; Propranolol; Quinazolines; Rats; Renin	1981
[Comprehensive use of clofelin and triampur compositum in treating hypertension]. Vrachebnoe delo, 1981, Issue:2 Topics: Adult; Antihypertensive Agents; Clonidine; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Triamterene	1981
Antihypertensive effect of BS 100-141, a new central acting antihypertensive agent. American heart journal, 1980, Volume: 99, Issue:1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Guanidines; Heart Rate; Humans; Hydrochlorothiazide; Male; Methyldopa; Middle Aged; Phenylacetates; Propranolol; Time Factors	1980
[Treatment of arterial hypertension in old age]. Kardiologia polska, 1980, Volume: 23, Issue:6 Topics: Age Factors; Aged; Allopurinol; Antihypertensive Agents; Blood Pressure; Clonidine; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Phthalazines; Propranolol	1980
[Treatment of hypertension with clofelin and adelfan-esidrex]. Vrachebnoe delo, 1980, Issue:9 Topics: Adolescent; Adult; Antihypertensive Agents; Clonidine; Dihydralazine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Reserpine	1980
[Alpha-methyldopa and renal function in arterial hypertension]. La Clinica terapeutica, 1980, May-15, Volume: 93, Issue:3 Topics: Antihypertensive Agents; Clonidine; Dihydralazine; Humans; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Kidney; Kidney Function Tests; Methyldopa; Propranolol	1980
Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population. American journal of hypertension, 2014, Volume: 27, Issue:10 Topics: Aged; Antihypertensive Agents; Asian People; Case-Control Studies; Child; Chrysanthemum; Clonidine; Dihydralazine; Drug Combinations; Drugs, Chinese Herbal; Female; Genetic Predisposition to Disease; Humans; Hydrochlorothiazide; Hypertension; Male; MicroRNAs; Middle Aged; Polymorphism, Single Nucleotide; Promethazine; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reserpine; Rutin	2014
Long-term treatment of clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not enalapril, impairs the sexual function in male spontaneously hypertensive rats. PloS one, 2015, Volume: 10, Issue:1 Topics: Animals; Antihypertensive Agents; Atenolol; Clonidine; Drug Administration Schedule; Enalapril; Hydrochlorothiazide; Hypertension; Male; Rats; Rats, Inbred SHR; Sexual Dysfunction, Physiological	2015
Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs. Die Pharmazie, 2016, Volume: 71, Issue:2 Topics: Acrylates; Algorithms; Animals; Antihypertensive Agents; Biological Availability; Chemistry, Pharmaceutical; Clonidine; Delayed-Action Preparations; Dogs; Drug Combinations; Excipients; Hydrochlorothiazide; Male; Tablets; Therapeutic Equivalency	2016