clonidine and guanfacine

clonidine has been researched along with guanfacine in 185 studies

Research

Studies (185)

Timeframe	Studies, this research(%)	All Research%
pre-1990	88 (47.57)	18.7374
1990's	33 (17.84)	18.2507
2000's	32 (17.30)	29.6817
2010's	30 (16.22)	24.3611
2020's	2 (1.08)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Bonhaus, DW; Chang, LK; Chang, TK; Daunt, DA; Eglen, RM; Hsu, SA; Jasper, JR; Lesnick, JD; Yamanishi, SS	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Agbaba, D; Filipic, S; Nikolic, K	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Arunachalam, KD; Loomis, CW	1
Buccafusco, JJ; Li, W	1
Camí, J; de la Torre, R; Gilabert, M; San, L	1
Baudendistel, LJ; Gibbons, JJ; Schweiss, JF; Smith, BD	1
Engberg, G; Eriksson, E	1
Epstein, M; Oster, JR	1
Bautista, L; Diéguez, A; Sopelana, P	1
Muga, R; Tor, J	1
Camí, J; Mata, R; Peri, JM; Porta, M; San, L	2
Opitz, K	1
Altés, J; Forteza-Rei, J; Jacas, C; Mestre, L; Muga, R; Tor, J	1
Doñate, F; Estañ, L; Martinez-Mir, MI; Morales-Olivas, FJ; Rubio, E	1
Gordh, T; Olsson, Y; Post, C	1
Andersson, RG; Grundström, N; Lindgren, BR	1
Demirel, E; Ercan, ZS; Hindioglu, F; Türker, RK	1
García Ruiz, ML; Gómez Pan, A; Lorenzo Navarro, L; Mancheño Rico, E; Rodríguez Arnao, MD; Teruel de Francisco, MC	1
File, SE; Johnston, AL	1
Archer, T; Danysz, W; Jonsson, G; Minor, BG; Mohammed, AK; Post, C	1
Coupry, I; Koenig, E; Lachaud, V; Parini, A; Podevin, RA	1
Cook, CC	1
Weber, MA	1
Kulkarni, SK; Kunchandy, J	2
Khanna, S; Kulkarni, SK; Kunchandy, J	1
Ohkubo, K; Otorii, T; Suzuki, K	1
Minami, M; Togashi, H; Yoshioka, M	1
Kulkarni, SK; Parale, MP	2
van Zwieten, PA	2
Reid, JL	1
Von Bruchhausen, F	1
Bramnert, M; Hökfelt, B	1
Archer, T; Freedman, J; Gordh, T; Minor, BG; Post, C	1
Hashimoto, T; Kogure, M; Takeuchi, K	1
Archer, T; Danysz, W; Minor, BG; Persson, ML; Post, C; Sundström, E	1
Izumi, F; Wada, A; Yanagihara, N	1
Baines, AD	1
Archer, T; Minor, BG; Post, C	1
Kobinger, W	1
Huchet, AM; Huguet, F; Legrand, M; Narcisse, G; Tsoucaris-Kupfer, D	1
Archer, T; Danysz, W; Kostowski, W; Minor, BG; Mohammed, A; Plaznik, A; Post, C; Pucilowski, O	1
Bedsole, G; Fillingim, J; Hall, D; Haring, O; Jagger, P; Lewin, A; McMahon, FG; Roginsky, M; Stepansky, W; Wilson, MF	1
Kulkarni, SK; Kunchandy, J; Mehta, AK	1
Alamo, C; Alguacil, LF; Cuenca, E; Santos, C	1
Hiremath, A; Jain, AK; McMahon, FG; Michael, R; Ryan, JR	1
Seedat, YK	1
Sambhi, MP	1
Ferber, G; Matejcek, M; Pokorny, R; Yamadera, H	1
Brunner, HR; Nussberger, J; Waeber, B	1
Bognar, IT; Enero, MA	1
Aleixandre, MA; Colado, MI; García de Jalón, PD; Martín, MI	2
Bannon, MJ; Roth, RH; Zigun, JR	1
Maruyama, S	1
Chiu, A; Seeman, P; Warsh, J; Weinreich, P	1
Cavero, I; Gomeni, R; Lefèvre-Borg, F; Roach, AG	1
Chin, W; Imai, S; Nakagawa, Y	1
Jarrott, B; Louis, WJ; Summers, RJ	4
Cavero, I; Doxey, JC; Roach, AG; Strachan, DA	1
Castaldi, WR; Fazio, JK; Hennig, CW; Hughes, CA; Spencer, BD	1
Buccafusco, JJ; Marshall, DC; Turner, RM	1
Timmermans, PB; Van Brummelen, P; Van Zwieten, PA	1
Eisenman, LM; Goldstein, FJ; Malseed, RT; Ossipov, MH	1
Scholtysik, G	1
Davies, DS; Dollery, CT	1
Hashimoto, K; Hashimoto, T; Imai, S; Nakagawa, Y; Takeda, K; Tsukada, T	1
Glusa, E; Markwardt, F	1
Schoop, AM; Timmermans, PB; van Zwieten, PA	1
Jie, K; Timmermans, PB; van Brummelen, P; van Zwieten, PA; Vermey, P	1
Kulkarni, SK; Mehta, AK	1
Doaré, L; Simon, P; Soubrié, P; Thiébot, MH	1
Decobert, M; Depoortere, H; Honoré, L	1
Alföldi, S; Farsang, C; Kapocsi, J; Vajda, L; Varga, K	1
Brown, MJ; Dollery, CT; Murphy, MB	1
Minami, M; Saito, I; Sano, M; Togashi, H	1
Bando, Y; Koike, Y; Minami, M; Saito, H; Shimamura, K; Togashi, H	1
Kobayashi, T; Koike, Y; Kurosawa, M; Minami, M; Saito, H; Shimamura, K; Togashi, H; Yasuda, H	1
Barber, ND; Reid, JL	2
Hamamura, M; Hashimoto, T; Imai, S; Kumada, M; Mitomi, A; Nakagawa, Y; Sakurai, H; Takeda, K	1
Rauh, J; Rosenthal, J; Schäfer, N	1
Jerie, P	1
DeVos, JE; Spiegel, R	1
Distler, A; Kirch, W; Lüth, B	1
Jäättelä, A	1
Brecht, HM; Krauskopf, R; Kugler, J; Raschig, A; Seus, R	1
Anguissola, AB; Lauro, R; Reda, G; Spallone, L	1
Kaiser, HJ; Raschig, A; Wetzels, E	1
Louis, WJ; Miach, PJ	1
Koike, Y; Saito, H; Shimamura, K; Togashi, H; Yomaida, I	1
Imai, S; Katano, Y; Nakagawa, Y; Otorii, T; Sakai, K; Shimamoto, N	1
Iizuka, H; Imai, S	1
Oguma, M; Ohkubo, K; Otorii, T; Suzuki, K	1
Thoolen, MJ; Timmermans, PB; van Zwieten, PA	1
Gazzola, C; Hunter, RA; Lisle, AT; Magner, T	1
Riddle, MA; Scahill, LD; Walkup, JT	1
Luo, L; Puke, MJ; Xu, XJ	1
Butterworth, JF; Strichartz, GR	1
Balldin, J; Berggren, U; Eriksson, E; Lindstedt, G; Sundkler, A	1
Shockley, DC; Wade, LH; Williams-Johnson, MM	1
Wiesenfeld-Hallin, Z; Wikberg, JE; Xu, XJ	1
Arnsten, AF; Hunt, RD; Steere, JC	1
Barnhill, LJ; Horrigan, JP	1
Durá Travé, T; González Montero, R; Gutiérrez Terán, M; Juste Ruiz, M; Mauri Dot, M; Moya Benavent, M	1
Kawasaki, H	1
Arnsten, AF; Jentsch, DJ; Li, BM; Steere, JC	1
Jentsch, JD; Katz, Z; Roth, RH; Wise, A	1
Popper, CW	1
Alamo, C; Arias, A; López-Muñoz, F; Rubio, G	1
DeBellis, MD; Halperin, JM; Harrison, M; Newcorn, JH; Schulz, K; Udarbe, JK	1
Jäkälä, P; Kejonen, K; Koivisto, E; Riekkinen, M; Riekkinen, P; Sirviö, J; Vanhanen, M	2
Bobirnac, I; Gazi, L; Loetscher, E; Parsley, S; Schoeffter, P	1
Jäkälä, P; Koivisto, E; Riekkinen, M; Riekkinen, P; Sirviö, J	1
Coull, JT; Frith, CD; Nobre, AC	1
Arnsten, AF; Birnbaum, SG; Podell, DM	1
Bisgard, GE; Herman, JK; O'Halloran, KD	1
Penner, SB; Smyth, DD	1
Archer, T; Fredriksson, A	1
Kang, BY; Kim, TS; Lee, SW	1
Biederman, J; Spencer, T; Wilens, T	1
Reeves, G; Schweitzer, J	1
Takishita, S; Yamazato, M	1
Laughlin, ML; Lester, M; Liles, LC; Palmiter, RD; Szot, P; Weinshenker, D	1
Hosseini, AR; Khansefid, N; Sabetkasaie, M; Sadat Ladgevardi, MA; Vala, S	1
George, TP; Morrow, BA; Roth, RH	1
McDougle, CJ	1
Avedian, T; Jentsch, JD; Kuperman, J; Marrs, W; Roth, RH	1
Bakshi, VP; Carasso, BS; Geyer, MA; Palomo, J; Powell, SB	1
Banaschewski, T; Heise, CA; Himpel, S; Rothenberger, A	1
Burns, JK; Kostenyuk, IA; Wu, Z; Yuan, R	1
Arnsten, AF; Biederman, J; Culpepper, L; Doyle, AE; Faraone, SV; Safren, SA; Spencer, TJ; Weiss, MD; Wilens, TE	1
Wilens, TE	1
Sica, DA	1
Pulges, O; Rinken, A	1
Arnsten, AF; Findling, RL; Scahill, L	1
Ji, JZ; Ji, XH; Li, BM; Zhang, H	1
Chen, W; Marvizón, JC; Song, B	1
Brawek, B; Feuerstein, TJ; Hoeren, M; Löffler, M; Mantovani, M; Steffens, M; van Velthoven, V	1
Elsworth, JD; Jentsch, JD; Roth, RH; Sanchez, D	1
Angelotti, T; Chen, Y; Jiao, K; Li, Y; Limbird, LE; Lu, R; Shields, AD; Wang, Q; Winder, DG; Zhang, Y; Zhou, Y	1
Scahill, L	1
Glazer, WM	1
Sallee, FR	1
Bidwell, LC; Kollins, SH; McClernon, FJ	1
Huang, YS; Tsai, MH	1
Aston-Jones, G; Smith, RJ	1
Roman, MW	1
Clement, HW; Schulz, E	1
Billinghurst, L; Carroll, A; Day, L; Dion, Y; Doja, A; Gorman, D; Luscombe, S; McKinlay, D; Pringsheim, T; Sandor, P; Steeves, T	1
Chung, K; Duong, S; Wigal, SB	1
Beauchemin, C; Hodgkins, PS; Lachaine, J; Sasane, R	1
Brown, K; Dohmeier, D; Hansen, K; Siebenaler, K; Zhang, Y	1
Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E	1
Alexander, GC; Conti, RM; Dorsey, ER; Dusetzina, SB; Garfield, CF; Higashi, AS; Huskamp, HA; Kornfield, R; Watson, S	1
Connor, DF; Newcorn, JH; Sallee, F	1
Calleja-Pérez, B; Fernández-Jaén, A; Fernández-Perrone, AL; López-Arribas, S; Martín Fernández-Mayoralas, D; Muñoz-Jareño, N	1
Heard, K; Le Lait, MC; Wang, GS	1
Chaki, S; Hikichi, H; Karasawa, J; Kawaura, K	1
Floresco, SB; Montes, DR; Stopper, CM	1
Blumenschein, K; Moga, DC; Sohn, M; Talbert, J	1
Chan, E; Fogler, JM; Hammerness, PG	1
Mattes, JA	1
Aragno, M; Mastrocola, R; Mengozzi, G; Parola, M; Sansoè, G	1
Jain, R; Katic, A	1
Anderson, RH; Mattingly, GW	1
Anand, S; Besag, FMC; Chan, EW; Cortese, S; Tong, H; Wong, ICK	1
Naguy, A	1
Anderson, PO	1
Osland, ST; Pringsheim, T; Steeves, TD	1
Carr, BJ; Nguyen, CT; Stell, WK	1
Cutler, AJ; Jain, R; Mattingly, GW; O'Neal, W	1
Dittmann, RW; Krone, B; Newcorn, JH	1

Reviews

39 review(s) available for clonidine and guanfacine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Use of centrally acting sympatholytic agents in the management of hypertension. Archives of internal medicine, 1991, Volume: 151, Issue:8 Topics: Aged; Clonidine; Guanfacine; Heart; Humans; Hypertension; Kidney; Methyldopa; Sympatholytics	1991
Clinical pharmacology of centrally acting antihypertensive agents. Journal of clinical pharmacology, 1989, Volume: 29, Issue:7 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Humans; Hypertension; Methyldopa; Phenylacetates; Risk Factors	1989
Alpha-adrenergic receptors and blood pressure control. The American journal of cardiology, 1986, Mar-28, Volume: 57, Issue:9 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Drug Evaluation; Guanfacine; Guanidines; Half-Life; Heart Rate; Humans; Hypertension; Phenylacetates; Prazosin; Receptors, Adrenergic, alpha	1986
Rudolf Buchheim lecture. Drugs as tools in research on adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:2 Topics: Angiotensin II; Animals; Azepines; Blood Pressure; Clonidine; Guanabenz; Guanfacine; Guanidines; Heart Rate; Humans; Imidazoles; Methoxamine; Oxymetazoline; Phenylacetates; Prazosin; Propanolamines; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiophenes; Xylazine; Yohimbine	1986
Clonidine and guanfacine--comparison of their effects on haemodynamics in hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Apr-06, Volume: 67, Issue:14 Topics: Blood Pressure; Cardiac Output; Clonidine; Epinephrine; Guanfacine; Guanidines; Hemodynamics; Humans; Hypertension; Phenylacetates; Renin; Vascular Resistance	1985
Pharmacology of centrally acting hypotensive drugs. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Imidazoles; Methyldopa; Phenylacetates; Prazosin; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Cholinergic; Yohimbine	1980
Role of alpha adrenoceptors in hypertension and in antihypertensive drug treatment. The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Calcium Channel Blockers; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Ketanserin; Methyldopa; Muscle, Smooth, Vascular; Phenylacetates; Piperazines; Piperidines; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Vascular Resistance	1984
Drug effects on the EEG of various species of laboratory animals. Neuropsychobiology, 1983, Volume: 9, Issue:4 Topics: 5-Hydroxytryptophan; Amantadine; Animals; Antihypertensive Agents; Azabicyclo Compounds; Brain; Cats; Chlormethiazole; Clonidine; Diazepam; Electroencephalography; Flunitrazepam; Guanabenz; Guanfacine; Guanidines; Imidazoles; Male; Nitrazepam; Pentobarbital; Phenylacetates; Piperazines; Piracetam; Rats; Sodium Oxybate; Yohimbine	1983
Disruptive behavior, hyperactivity, and learning disabilities in children with Tourette's syndrome. Advances in neurology, 1995, Volume: 65 Topics: Adolescent; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Clonidine; Comorbidity; Dextroamphetamine; Guanfacine; Humans; Learning Disabilities; Methylphenidate; Pemoline; Selegiline; Tourette Syndrome	1995
The contribution of alpha 2-noradrenergic mechanisms of prefrontal cortical cognitive function. Potential significance for attention-deficit hyperactivity disorder. Archives of general psychiatry, 1996, Volume: 53, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Attention Deficit Disorder with Hyperactivity; Clonidine; Cognition Disorders; Guanfacine; Haplorhini; Humans; Locus Coeruleus; Models, Neurological; Neural Pathways; Norepinephrine; Prefrontal Cortex; Receptors, Adrenergic, alpha-2	1996
[Centrally acting sympathetic inhibitors for therapy of patients with hypertension]. Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:8 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Fibers; Antihypertensive Agents; Clonidine; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Sympatholytics	1997
Antidepressants in the treatment of attention-deficit/hyperactivity disorder. The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 14 Topics: Adolescent; Adult; Age Factors; Antidepressive Agents; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; Cognitive Behavioral Therapy; Combined Modality Therapy; Dextroamphetamine; Guanfacine; Humans; Methamphetamine; Methylphenidate; Monoamine Oxidase Inhibitors; Selective Serotonin Reuptake Inhibitors	1997
Alpha 2 adrenergic agonists. Neurochemistry, efficacy, and clinical guidelines for use in children. Pediatric clinics of North America, 1998, Volume: 45, Issue:5 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disorders; Child; Clinical Protocols; Clonidine; Female; Guanfacine; Humans; Locus Coeruleus; Male; Tic Disorders	1998
Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. The international journal of neuropsychopharmacology, 2004, Volume: 7, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimulants; Child; Clonidine; Delayed-Action Preparations; Evidence-Based Medicine; Guanfacine; Humans; Methylphenidate; Propylamines	2004
Pharmacological management of attention-deficit hyperactivity disorder. Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:6 Topics: Adrenergic alpha-Agonists; Amphetamines; Antidepressive Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimulants; Child; Clonidine; Guanfacine; Humans; Methylphenidate; Propylamines	2004
[Centrally-acting antihypertensive drugs]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoline Receptors; Kidney; Methyldopa; Norepinephrine; Pressoreceptors; Receptors, Drug; Renal Circulation; Sodium; Sympathetic Nervous System; Sympatholytics; Vascular Resistance	2004
The safety of non-stimulant agents for the treatment of attention-deficit hyperactivity disorder. Expert opinion on drug safety, 2005, Volume: 4, Issue:2 Topics: Adrenergic alpha-Agonists; Adult; Antidepressive Agents, Tricyclic; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Child; Clonidine; Desipramine; Guanfacine; Humans; Imipramine; Nortriptyline; Propylamines	2005
Mechanism of action of agents used in attention-deficit/hyperactivity disorder. The Journal of clinical psychiatry, 2006, Volume: 67 Suppl 8 Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimulants; Child; Clonidine; Guanfacine; Humans; Nicotinic Antagonists; Pharmacogenetics; Propylamines	2006
Centrally acting antihypertensive agents: an update. Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:5 Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Oxazoles; Rilmenidine	2007
alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data. Journal of child and adolescent psychopharmacology, 2007, Volume: 17, Issue:4 Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Clonidine; Controlled Clinical Trials as Topic; Guanfacine; History, 20th Century; History, 21st Century; Humans; Prefrontal Cortex; Receptors, Adrenergic, alpha-2	2007
Alpha-2 adrenergic agonists in children with inattention, hyperactivity and impulsiveness. CNS drugs, 2009, Volume: 23 Suppl 1 Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Child; Child Development Disorders, Pervasive; Child, Preschool; Clonidine; Guanfacine; Humans; Impulsive Behavior	2009
The role of alpha2-adrenergic agonists in attention-deficit/hyperactivity disorder. Postgraduate medicine, 2010, Volume: 122, Issue:5 Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as Topic; Clonidine; Delayed-Action Preparations; Drug Therapy, Combination; Electrocardiography; Guanfacine; Humans; Methylphenidate	2010
Cognitive enhancers for the treatment of ADHD. Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:2 Topics: Adult; Amphetamine; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Child; Cholinergic Agents; Clonidine; Cognition; Executive Function; Guanfacine; Humans; Intelligence; Methylphenidate; Nootropic Agents; Propylamines; Reward; Social Behavior	2011
Long-term outcomes with medications for attention-deficit hyperactivity disorder: current status of knowledge. CNS drugs, 2011, Volume: 25, Issue:7 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; Delayed-Action Preparations; Guanfacine; Humans; Propylamines; Treatment Outcome	2011
New additions to the psychopharmacopia: extended release formulations. Issues in mental health nursing, 2011, Volume: 32, Issue:11 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comparative Effectiveness Research; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Approval; Evidence-Based Nursing; Guanfacine; Humans; Mental Disorders; Psychotropic Drugs; Tics; Trazodone; Treatment Outcome; United States	2011
[α2-Adrenergic agonists, and drugs for ADHD]. Pharmazie in unserer Zeit, 2011, Volume: 40, Issue:6 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Drug Therapy, Combination; Guanfacine; Humans; Sex Factors	2011
Canadian guidelines for the evidence-based treatment of tic disorders: pharmacotherapy. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2012, Volume: 57, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Antipsychotic Agents; Canada; Child; Clonidine; Evidence-Based Medicine; Guanfacine; Humans; Practice Guidelines as Topic; Tic Disorders; Tourette Syndrome	2012
Metabolic, toxicological, and safety considerations for drugs used to treat ADHD. Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:5 Topics: Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as Topic; Clonidine; Comorbidity; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Guanfacine; Humans; Methylphenidate; Propylamines	2012
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. Journal of child psychology and psychiatry, and allied disciplines, 2013, Volume: 54, Issue:3 Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure; Body Size; Cardiovascular Diseases; Central Nervous System Stimulants; Child; Clonidine; Dextroamphetamine; Growth Disorders; Guanfacine; Heart Rate; Humans; Lisdexamfetamine Dimesylate; Methylphenidate; Propylamines; Psychoses, Substance-Induced; Seizures; Sleep Wake Disorders; Substance-Related Disorders; Suicide Prevention; Tic Disorders; Treatment Outcome	2013
A review of the rationale and clinical utilization of α2-adrenoceptor agonists for the treatment of attention-deficit/hyperactivity and related disorders. Journal of child and adolescent psychopharmacology, 2013, Volume: 23, Issue:5 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Attention Deficit Disorder with Hyperactivity; Clonidine; Delayed-Action Preparations; Drug Approval; Drug Design; Guanfacine; Humans; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration	2013
[Autism and attention deficit hyperactivity disorder: pharmacological intervention]. Revista de neurologia, 2013, Sep-06, Volume: 57 Suppl 1 Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimulants; Child; Child Development Disorders, Pervasive; Clonidine; Dopamine Uptake Inhibitors; Drug Evaluation; Guanfacine; Humans; Methylphenidate; Neuroimaging; Propylamines; Psychotropic Drugs; Randomized Controlled Trials as Topic; Treatment Outcome	2013
Treatment of Attention-Deficit/Hyperactivity Disorder in Adolescents: A Systematic Review. JAMA, 2016, May-10, Volume: 315, Issue:18 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clonidine; Delayed-Action Preparations; Guanfacine; Humans; Methylphenidate; Motivation; Psychotherapy; Randomized Controlled Trials as Topic; Social Skills	2016
Current and Investigational Medication Delivery Systems for Treating Attention-Deficit/Hyperactivity Disorder. The primary care companion for CNS disorders, 2016, Aug-18, Volume: 18, Issue:4 Topics: Adrenergic Agents; Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as Topic; Clonidine; Guanfacine; Humans; Methylphenidate; Treatment Outcome	2016
Optimizing outcomes in ADHD treatment: from clinical targets to novel delivery systems. CNS spectrums, 2016, Volume: 21, Issue:S1 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Anxiety Disorders; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System Stimulants; Clonidine; Comorbidity; Delayed-Action Preparations; Depressive Disorder; Dextroamphetamine; Guanfacine; Humans; Methylphenidate	2016
Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological Quality Assessment. Paediatric drugs, 2017, Volume: 19, Issue:3 Topics: Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Eszopiclone; Glutamates; Guanfacine; Humans; Melatonin; Observational Studies as Topic; Pyridines; Randomized Controlled Trials as Topic; Sleep Initiation and Maintenance Disorders; Zolpidem	2017
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders. The Cochrane database of systematic reviews, 2018, 06-26, Volume: 6 Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Preschool; Clonidine; Desipramine; Dextroamphetamine; Female; Guanfacine; Humans; Male; Methylphenidate; Randomized Controlled Trials as Topic; Selegiline; Tic Disorders	2018
Current and future nonstimulants in the treatment of pediatric ADHD: monoamine reuptake inhibitors, receptor modulators, and multimodal agents. CNS spectrums, 2022, Volume: 27, Issue:2 Topics: Adolescent; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; Guanfacine; Humans; United States	2022
Nonstimulant Treatments for ADHD. Child and adolescent psychiatric clinics of North America, 2022, Volume: 31, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clonidine; Guanfacine; Humans	2022

Trials

25 trial(s) available for clonidine and guanfacine

Article	Year
Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts. British journal of addiction, 1992, Volume: 87, Issue:8 Topics: Adult; Circadian Rhythm; Clonidine; Double-Blind Method; Guanfacine; Heroin; Heroin Dependence; Humans; Hydrocortisone; Male; Methadone; Substance Withdrawal Syndrome	1992
Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial. British journal of addiction, 1990, Volume: 85, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Guanfacine; Guanidines; Heroin Dependence; Humans; Male; Methadone; Phenylacetates; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	1990
[Comparative effectiveness of alpha-2 adrenergic agonists (clonidine-guanfacine) in the hospital detoxification of opiate addicts]. Medicina clinica, 1990, Feb-10, Volume: 94, Issue:5 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Evaluation; Female; Guanfacine; Guanidines; Heart Rate; Heroin; Hospitalization; Humans; Male; Phenylacetates; Random Allocation; Substance Withdrawal Syndrome	1990
[Determination of growth hormone: comparison between a physiologic stimulus (exercise) and pharmacologic stimuli (clonidine/guanfacine)]. Anales espanoles de pediatria, 1989, Volume: 30, Issue:3 Topics: Adolescent; Adrenergic alpha-Agonists; Child; Child, Preschool; Clonidine; Drug Evaluation; Exercise; Female; Growth Hormone; Guanfacine; Guanidines; Humans; Male; Phenylacetates	1989
Success and failure at inpatient heroin detoxification. British journal of addiction, 1989, Volume: 84, Issue:1 Topics: Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Guanfacine; Guanidines; Heroin Dependence; Humans; Male; Methadone; Phenylacetates; Psychiatric Department, Hospital; Random Allocation	1989
Naloxone enhances the increase in plasma growth hormone induced by alpha 2-adrenergic stimulation in healthy males. Acta endocrinologica, 1987, Volume: 114, Issue:2 Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Growth Hormone; Guanfacine; Guanidines; Humans; Male; Naloxone; Phenylacetates; Receptors, Opioid	1987
Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension. The American journal of cardiology, 1986, Mar-28, Volume: 57, Issue:9 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Phenylacetates; Random Allocation; Substance Withdrawal Syndrome	1986
Clonidine and guanfacine in hypertension. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:3 Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Phenylacetates; Random Allocation	1985
Electroencephalographic and psychometric assessment of the CNS effects of single doses of guanfacine hydrochloride (Estulic) and clonidine (Catapres). Neuropsychobiology, 1985, Volume: 14, Issue:2 Topics: Adult; Arousal; Blood Pressure; Brain; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Emotions; Guanfacine; Guanidines; Heart Rate; Humans; Male; Phenylacetates	1985
Centrally acting drugs in antihypertensive therapy. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Heart Rate; Humans; Hypnotics and Sedatives; Male; Phenylacetates; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Xerostomia	1980
Effects of clonidine and guanfacine in essential hypertension. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5 Topics: Adult; Blood Pressure; Cardiac Output; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Indium; Injections, Intravenous; Middle Aged; Naloxone; Phenylacetates; Radioisotopes; Renin	1984
Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man. European journal of clinical pharmacology, 1984, Volume: 27, Issue:1 Topics: Adult; Blood Pressure; Clonidine; Female; Growth Hormone; Guanfacine; Guanidines; Heart Rate; Humans; Hypnotics and Sedatives; Infusions, Parenteral; Male; Norepinephrine; Phenylacetates; Sympatholytics	1984
Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Double-Blind Method; Guanfacine; Guanidines; Humans; Male; Phenylacetates; Sleep; Sleep, REM; Wakefulness	1980
Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Therapy, Combination; Epinephrine; Female; Guanfacine; Guanidines; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Phenoxybenzamine; Phenylacetates; Triamterene	1980
Comparison of guanfacine and clonidine as antihypertensive agents. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Antihypertensive Agents; Blood Pressure; Clonidine; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Phenylacetates; Time Factors; Xerostomia	1980
Differences in psychic performance with guanfacine and clonidine in normotensive subjects. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adult; Antihypertensive Agents; Arousal; Attention; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Humans; Male; Mental Processes; Motivation; Norepinephrine; Phenylacetates; Psychometrics; Reaction Time; Self-Assessment	1980
Hypotensive effect of guanfacine in essential hypertension: a comparison with clonidine. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Middle Aged; Phenylacetates	1980
[A new antihypertensive agent used in a clinical setting]. Medizinische Klinik, 1980, Sep-12, Volume: 75, Issue:19 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Male; Middle Aged; Phenylacetates; Placebos	1980
Evaluation of guanfacine and clonidine in essential hypertension: a single-blind crossover study. The Medical journal of Australia, 1980, Oct-04, Volume: 2, Issue:7 Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates	1980
Guanfacine as an alpha-2-agonist inducer of growth hormone secretion--a comparison with clonidine. Psychoneuroendocrinology, 1993, Volume: 18, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Growth Hormone; Guanfacine; Heart Rate; Humans; Hypnotics and Sedatives; Male; Middle Aged; Sodium Chloride; Stimulation, Chemical	1993
[Sensitivity of the clonidine and guanfacine tests (alpha-2-adrenergic agonists) as pharmacologic stimulants of growth hormone. Effects on plasma cortisol]. Anales espanoles de pediatria, 1996, Volume: 45, Issue:6 Topics: Adrenergic alpha-Agonists; Child; Clonidine; Female; Growth Disorders; Guanfacine; Human Growth Hormone; Humans; Hydrocortisone; Male; Sensitivity and Specificity	1996
Guanfacine and clonidine, alpha 2-agonists, improve paired associates learning, but not delayed matching to sample, in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Association Learning; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Female; Guanfacine; Humans; Male; Memory, Short-Term; Neuropsychological Tests; Psychomotor Performance	1999
Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:5 Topics: Adrenergic alpha-Agonists; Adult; Attention; Blood Pressure; Clonidine; Double-Blind Method; Frontal Lobe; Guanfacine; Humans; Memory; Mental Processes; Neuropsychological Tests; Psychomotor Performance	1999
Clonidine, but not guanfacine, impairs choice reaction time performance in young healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 21, Issue:4 Topics: Adrenergic alpha-Agonists; Adult; Attention; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Female; Guanfacine; Humans; Male; Motor Activity; Pain Measurement; Psychomotor Performance; Reaction Time	1999
The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting. Cerebral cortex (New York, N.Y. : 1991), 2001, Volume: 11, Issue:1 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analysis of Variance; Attention; Clonidine; Cues; Female; Guanfacine; Humans; Male; Middle Aged; Orientation; Parietal Lobe; Reaction Time; Temporal Lobe	2001

Other Studies

121 other study(ies) available for clonidine and guanfacine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochemical pharmacology, 1998, Apr-01, Volume: 55, Issue:7 Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cell Line; Cell Membrane; Cyclic AMP; Genetic Vectors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mice; Protein Binding; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Proteins	1998
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
QSAR study of imidazoline antihypertensive drugs. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Animals; Blood Pressure; Clonidine; Guanfacine; Hot Temperature; Injections, Intravenous; Injections, Spinal; Lumbosacral Region; Male; Nociceptors; Prazosin; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Urethane	1992
Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition. Research communications in chemical pathology and pharmacology, 1992, Volume: 75, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Cholinesterase Inhibitors; Clonidine; Diazepam; Dose-Response Relationship, Drug; Guanabenz; Guanfacine; Lethal Dose 50; Male; Motor Activity; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Soman	1992
A comparison of two epidural alpha 2-agonists, guanfacine and clonidine, in regard to duration of antinociception, and ventilatory and hemodynamic effects in goats. Anesthesia and analgesia, 1992, Volume: 74, Issue:5 Topics: Animals; Clonidine; Drug Evaluation, Preclinical; Goats; Guanfacine; Hemodynamics; Injections, Epidural; Male; Pain; Respiration; Time Factors	1992
Effects of alpha 2-adrenoceptor agonists on locus coeruleus firing rate and brain noradrenaline turnover in N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-treated rats. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:5 Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Electrodes; Guanfacine; In Vitro Techniques; Locus Coeruleus; Male; Norepinephrine; Quinolines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha	1991
[Factors affecting the course of hospital detoxication of drug addicts]. Medicina clinica, 1991, Sep-21, Volume: 97, Issue:9 Topics: Adult; Cannabis; Clonidine; Cocaine; Evaluation Studies as Topic; Female; Guanfacine; Heroin Dependence; Humans; Male; Mental Disorders; Methadone; Narcotics; Substance-Related Disorders	1991
[Drug addiction and detoxication units]. Medicina clinica, 1991, Sep-21, Volume: 97, Issue:9 Topics: Adult; Ambulatory Care; Clonidine; Female; Guanfacine; Heroin Dependence; Hospital Units; Humans; Male; Mental Disorders; Methadone; Prognosis; Spain; Substance-Related Disorders	1991
The effect of clonidine and related substances on voluntary ethanol consumption in rats. Drug and alcohol dependence, 1990, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Alcohol Drinking; Animals; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Eating; Guanfacine; Guanidines; Phenylacetates; Rats; Rats, Inbred Strains; Thiophenes; Yohimbine	1990
Study on the histamine-like activity of guanfacine. The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:8 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diethylstilbestrol; Dose-Response Relationship, Drug; Female; Guanfacine; Guinea Pigs; Heart Atria; Myocardial Contraction; Potassium Chloride; Rats; Rats, Inbred Strains; Uterine Contraction	1990
Evaluation of the toxicity of subarachnoid clonidine, guanfacine, and a substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration. Anesthesia and analgesia, 1986, Volume: 65, Issue:12 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Evaluation, Preclinical; Guanfacine; Guanidines; Injections, Spinal; Male; Microscopy, Electron; Phenylacetates; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Nerve Roots; Substance P	1986
Comparison of the effects of clonidine and guanfacine on the histamine liberation from human mast cells and basophils and on the human bronchial smooth muscle activity. Arzneimittel-Forschung, 1987, Volume: 37, Issue:5 Topics: Adrenergic alpha-Agonists; Basophils; Bronchi; Carbachol; Cimetidine; Clonidine; Electric Stimulation; Guanfacine; Guanidines; Histamine Release; Humans; In Vitro Techniques; Lung; Mast Cells; Muscle Contraction; Muscle, Smooth; Phenylacetates	1987
Endothelium modulates the effects of alpha-adrenoceptor agonists in vascular smooth muscle. General pharmacology, 1989, Volume: 20, Issue:1 Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arteries; Clonidine; Endothelium, Vascular; Female; Guanfacine; Guanidines; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylacetates; Phenylephrine; Pulmonary Artery; Rabbits	1989
Yohimbine's anxiogenic action: evidence for noradrenergic and dopaminergic sites. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Animals; Anxiety; Apomorphine; Azepines; Benzazepines; Clonidine; Dopamine Agents; Ergolines; Guanfacine; Guanidines; Learning; Male; Norepinephrine; Phenylacetates; Phenylephrine; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Yohimbine	1989
Adaptive changes in alpha-2 adrenoceptor mediated responses: analgesia, hypothermia and hypoactivity. Pharmacology & toxicology, 1989, Volume: 65, Issue:2 Topics: Adaptation, Physiological; Adrenergic alpha-Agonists; Analgesia; Animals; Body Temperature; Brain Chemistry; Clonidine; Desipramine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Hypnotics and Sedatives; Hypothermia, Induced; Male; Motor Activity; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha	1989
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors]. Archives des maladies du coeur et des vaisseaux, 1989, Volume: 82, Issue:7 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Guanfacine; Guanidines; Idazoxan; Kidney Tubules, Proximal; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine	1989
Inpatient heroin detoxification: a comment. British journal of addiction, 1989, Volume: 84, Issue:11 Topics: Adrenergic alpha-Agonists; Clonidine; Follow-Up Studies; Guanfacine; Guanidines; Heroin Dependence; Humans; Methadone; Patient Dropouts; Phenylacetates	1989
Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice. Psychopharmacology, 1987, Volume: 93, Issue:1 Topics: Animals; Anticonvulsants; Azepines; Benzodiazepinones; Brain; Clonidine; Convulsants; Guanfacine; Guanidines; Imidazoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, GABA-A; Seizures	1987
Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats. Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 275, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Azepines; Clonidine; Female; Gastric Acid; Gastric Acidity Determination; Guanfacine; Guanidines; Humans; Male; Phenylacetates; Pylorus; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Time Factors	1985
Antagonism of hypotensive and bradycardic effects of centrally administered guanfacine by metiamide in anesthetized rabbits. Japanese heart journal, 1985, Volume: 26, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanfacine; Guanidines; Heart Rate; Injections, Intraventricular; Male; Metiamide; Phenylacetates; Rabbits; Thiourea	1985
[The effect of clonidine and guanfacine on blood pressure]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 86, Issue:4 Topics: Animals; Autonomic Fibers, Preganglionic; Behavior, Animal; Blood Pressure; Brain; Cardiovascular System; Cats; Chemical Phenomena; Chemistry; Clonidine; Dogs; Dopamine; Guanfacine; Guanidines; Humans; Hypnotics and Sedatives; Kinetics; Lipid Metabolism; Neural Pathways; Neurotransmitter Agents; Norepinephrine; Phenylacetates; Rats; Receptors, Adrenergic, alpha; Receptors, Histamine H2; Receptors, Opioid; Receptors, Prostaglandin; Substance Withdrawal Syndrome	1985
Studies with alpha 2-adrenoceptor agonists and alcohol abstinence syndrome in rats. Psychopharmacology, 1986, Volume: 88, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Ethanol; Guanfacine; Guanidines; Male; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome	1986
Overview of alpha 2-adrenoceptor agonists with a central action. The American journal of cardiology, 1986, Mar-28, Volume: 57, Issue:9 Topics: Adrenergic alpha-Agonists; Blood Pressure; Central Nervous System; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates	1986
Inhibitory action of guanfacine on glucose uptake by adipose tissue not related to its alpha 2-adrenergic stimulatory potency. Arzneimittel-Forschung, 1985, Volume: 35, Issue:12 Topics: Adipose Tissue; Adrenergic alpha-Agonists; Animals; Carbon Dioxide; Clonidine; Deoxyglucose; Glucose; Guanfacine; Guanidines; In Vitro Techniques; Insulin; Kinetics; Male; Phenylacetates; Rats; Rats, Inbred Strains	1985
Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats. Psychopharmacology, 1986, Volume: 90, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Azepines; Clonidine; Diazepam; Guanfacine; Guanidines; Male; Motor Activity; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine	1986
Antinociceptive effects and spinal cord tissue concentrations after intrathecal injection of guanfacine or clonidine into rats. Anesthesia and analgesia, 1987, Volume: 66, Issue:4 Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Clonidine; Guanfacine; Guanidines; Hydrogen-Ion Concentration; Male; Phenylacetates; Rats; Rats, Inbred Strains; Spinal Cord; Time Factors	1987
Comparison of agonistic and antagonistic actions of guanabenz and guanfacin on alpha 1 and alpha 2-adrenoceptors in isolated smooth muscles. Japanese journal of pharmacology, 1987, Volume: 43, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Clonidine; Guanabenz; Guanfacine; Guanidines; In Vitro Techniques; Male; Muscle Denervation; Muscle, Smooth; Muscle, Smooth, Vascular; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vas Deferens	1987
Increased antinociception by alpha-adrenoceptor drugs after spinal cord noradrenaline depletion. European journal of pharmacology, 1987, May-07, Volume: 137, Issue:1 Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Benzylamines; Clonidine; Guanfacine; Guanidines; Hydroxydopamines; Injections, Spinal; Male; Morphine; Norepinephrine; Oxidopamine; Phenylacetates; Rats; Rats, Inbred Strains; Spinal Cord	1987
Effects of alpha 2-adrenergic agonists on carbachol-stimulated catecholamine synthesis in cultured bovine adrenal medullary cells. Biochemical pharmacology, 1987, Nov-15, Volume: 36, Issue:22 Topics: 2-Hydroxyphenethylamine; Adrenal Medulla; Adrenergic alpha-Agonists; Animals; Calcium; Carbachol; Catecholamines; Cattle; Cells, Cultured; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Octopamine; Oxymetazoline; Phenylacetates; Tyrosine; Tyrosine 3-Monooxygenase; Yohimbine	1987
Is there a role for renal alpha 2-adrenoceptors in the pathogenesis of hypertension? Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:8 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Gluconeogenesis; Guanfacine; Guanidines; Hypertension; In Vitro Techniques; Kidney; Methoxamine; Norepinephrine; Parathyroid Glands; Phenylacetates; Prazosin; Pyruvates; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Renal Circulation; Vascular Resistance; Yohimbine	1987
Evidence for crosstolerance to the analgesic effects between morphine and selective alpha 2-adrenoceptor agonists. Journal of neural transmission, 1988, Volume: 72, Issue:1 Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Clonidine; Drug Tolerance; Guanfacine; Guanidines; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Norepinephrine; Phenylacetates; Rats; Rats, Inbred Strains	1988
Interaction between central alpha 1- and alpha 2-adrenoceptors on sympathetic tone in rats. Neuropharmacology, 1986, Volume: 25, Issue:5 Topics: Animals; Azepines; Brain; Clonidine; Guanfacine; Guanidines; Heart Rate; Injections, Intraventricular; Male; Phenylacetates; Piperoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Vagotomy	1986
Clonidine--induced behavioural despair in mice: reversal by antidepressants. Psychopharmacology, 1986, Volume: 89, Issue:2 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Azepines; Clonidine; Depression; Diazepam; Guanfacine; Guanidines; Lithium; Male; Phenylacetates; Rats; Rats, Inbred Strains; Tranylcypromine; Yohimbine	1986
Chronic treatment with antidepressant drugs and ECT differentially modifies the hypothermic action of clonidine and guanfacine. Pharmacology & toxicology, 1987, Volume: 60, Issue:4 Topics: Animals; Antidepressive Agents; Body Temperature; Clonidine; Drug Interactions; Electroshock; Ether; Ethyl Ethers; Guanfacine; Guanidines; Male; Phenylacetates; Rats; Rats, Inbred Strains	1987
Anti-inflammatory actions of clonidine, guanfacine and B-HT 920 against various inflammagen-induced acute paw oedema in rats. Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 279, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Azepines; Bradykinin; Carrageenan; Clonidine; Edema; Formaldehyde; Guanfacine; Guanidines; Histamine; Injections, Intraventricular; Male; Phenylacetates; Rats; Rats, Inbred Strains; Serotonin; Time Factors	1986
Yohimbine reduces morphine tolerance in guinea-pig ileum. Life sciences, 1987, Jan-12, Volume: 40, Issue:2 Topics: Animals; Clonidine; Drug Tolerance; Female; Guanfacine; Guanidines; Guinea Pigs; Ileum; Male; Morphine; Muscle, Smooth; Phenylacetates; Yohimbine	1987
Effects of clonidine and guanfacine on haemodynamics in hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Oct-12, Volume: 68, Issue:8 Topics: Blood Pressure; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Phenylacetates	1985
Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin. Journal of cardiovascular pharmacology, 1984, Volume: 6 Suppl 5 Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Guanfacine; Guanidines; Humans; Phenylacetates; Renin; Renin-Angiotensin System; Sodium; Vasopressins	1984
alpha 1-Antagonist activity of the alpha 2-adrenoceptor agonist guanabenz in perfused mesenteric artery of the rat. European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2 Topics: Animals; Blood Pressure; Clonidine; Female; Guanabenz; Guanfacine; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Perfusion; Phenylacetates; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha	1984
Sensitivity of the myenteric plexus alpha2-receptor from guinea pig treated with clonidine or guanfacine. Archivos de farmacologia y toxicologia, 1984, Volume: 10, Issue:2 Topics: Animals; Clonidine; Guanfacine; Guanidines; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Phenylacetates; Receptors, Adrenergic, alpha	1984
Comparison of two alpha-noradrenergic agonists (clonidine and guanfacine) on norepinephrine turnover in the cortex of rats during morphine abstinence. European journal of pharmacology, 1981, Apr-09, Volume: 70, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Humans; Methyltyrosines; Morphine Dependence; Norepinephrine; Phenylacetates; Rats; Substance Withdrawal Syndrome	1981
Inhibition by topically applied clonidine and guanfacine on the pressor response to stimulation of the locus coeruleus in cats. Japanese journal of pharmacology, 1981, Volume: 31, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cats; Clonidine; Electric Stimulation; Female; Guanfacine; Guanidines; Hypothalamus, Posterior; Injections; Locus Coeruleus; Male; Phenylacetates	1981
Multiple binding sites for [3H]clonidine and [3H]WB-4101 in rat brain. Canadian journal of physiology and pharmacology, 1981, Volume: 59, Issue:11 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Clonidine; Dioxanes; Dioxins; Guanfacine; Guanidines; Hydroxydopamines; Male; Phenylacetates; Rats; Rats, Inbred Strains	1981
Pharmacological evidence favoring a similarity between alpha adrenoceptors mediating sleep in chicks and cardiac presynaptic alpha-2 receptors in rats. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Chickens; Clonidine; Guanfacine; Guanidines; Heart; Heart Rate; Male; Methoxamine; Nordefrin; Oxymetazoline; Phentolamine; Phenylacetates; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Sleep; Xylazine; Yohimbine	1982
[Effects of guanfacine on pre- and postsynaptic alpha-adrenoceptors studied in comparison with those of clonidine]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:5 Topics: Adrenalectomy; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Clonidine; Decerebrate State; Guanfacine; Guanidines; Heart Rate; Male; Phentolamine; Phenylacetates; Prazosin; Rats; Rats, Inbred Strains; Yohimbine	1982
Characterization of central alpha-adrenoceptors using 3H-clonidine and its derivatives. Chest, 1983, Volume: 83, Issue:2 Suppl Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cerebral Cortex; Clonidine; Guanfacine; Guanidines; Phenylacetates; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tritium	1983
[3H]-guanfacine: a radioligand that selectively labels high affinity alpha2-adrenoceptor sites in homogenates of rat brain. British journal of pharmacology, 1982, Volume: 75, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Female; Guanfacine; Guanidines; Guanosine Triphosphate; In Vitro Techniques; Male; Phenylacetates; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sodium; Tritium	1982
Sleeping times evoked by alpha adrenoceptor agonists in two-day-old chicks: an experimental model to evaluate full and partial agonists at central alpha-2 adrenoceptors. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Chickens; Clonidine; Guanabenz; Guanfacine; Guanidines; Imidazoles; Phenylacetates; Quinoxalines; Receptors, Adrenergic, alpha; Sleep; Thiophenes; Time Factors; Xylazine	1983
Influences on morphine action in the myenteric plexus from guinea pig of alpha 2 receptor stimulation. Archivos de farmacologia y toxicologia, 1983, Volume: 9, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Synergism; Female; Guanfacine; Guanidines; Guinea Pigs; Humans; Male; Morphine; Muscle Contraction; Myenteric Plexus; Phenylacetates; Stimulation, Chemical; Substance Withdrawal Syndrome	1983
Duration of tonic immobility in chickens as a function of alpha-adrenergic receptor stimulation and blockade. Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:5 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Chickens; Clonidine; Guanfacine; Guanidines; Methoxamine; Naphazoline; Phenylacetates; Phenylephrine; Prazosin; Restraint, Physical; Time Factors; Yohimbine	1984
A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats. Life sciences, 1984, Sep-24, Volume: 35, Issue:13 Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Heart Rate; Humans; Male; Morphine Dependence; Naloxone; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome	1984
Effect of alpha 2 adrenergic agents upon central etorphine antinociception in the cat. Brain research, 1984, Aug-20, Volume: 309, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Cats; Clonidine; Drug Interactions; Etorphine; Guanfacine; Guanidines; Kinetics; Male; Morphinans; Nociceptors; Pain; Phenylacetates; Yohimbine	1984
Pharmacology of guanfacine. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Dogs; Dopamine; Dose-Response Relationship, Drug; Guanfacine; Guanidines; Heart Rate; Hypnotics and Sedatives; Phenylacetates; Rabbits; Rats; Receptors, Adrenergic, alpha; Sympathetic Nervous System	1980
Peripheral effects of guanfacine compared to those of clonidine in the dog. Japanese circulation journal, 1980, Volume: 44, Issue:11 Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Circulation; Clonidine; Dogs; Female; Femur; Ganglia; Guanfacine; Guanidines; Heart Rate; Hemodynamics; Kidney; Male; Phenylacetates; Regional Blood Flow; Synaptic Transmission	1980
Selectivity of a series of clonidine-like drugs for alpha 1 and alpha 2 adrenoceptors in rat brain. Neuroscience letters, 1980, Volume: 20, Issue:3 Topics: Aniline Compounds; Animals; Cerebral Cortex; Clonidine; Guanabenz; Guanfacine; Guanidines; Imidazoles; In Vitro Techniques; Indoramin; Naphazoline; Oxazoles; Phenylacetates; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Thiophenes; Toluidines	1980
Influence of clonidine-like hypotensive drugs on adrenergic platelet reactions. Biochemical pharmacology, 1981, Jun-01, Volume: 30, Issue:11 Topics: Antihypertensive Agents; Blood Platelets; Clonidine; Epinephrine; Guanabenz; Guanfacine; Guanidines; Humans; In Vitro Techniques; Phenylacetates; Platelet Aggregation; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Xylazine	1981
Comparison of [3H]clonidine and [3H]guanfacine binding to alpha 2 adrenoceptors in membranes from rat cerebral cortex. Neuroscience letters, 1981, Aug-07, Volume: 25, Issue:1 Topics: Animals; Cerebral Cortex; Clonidine; Female; Guanfacine; Guanidines; Kinetics; Male; Phenylacetates; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Synaptic Membranes	1981
Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine. Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6 Topics: Animals; Antihypertensive Agents; Binding Sites; Brain; Clonidine; Guanfacine; Guanidines; In Vitro Techniques; Kinetics; Male; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tritium	1982
Identification of vascular postsynaptic alpha 1- and alpha 2-adrenoceptors in man. Circulation research, 1984, Volume: 54, Issue:4 Topics: Adult; Azepines; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Doxazosin; Female; Guanfacine; Guanidines; Heart Rate; Humans; Male; Methoxamine; Muscle, Smooth, Vascular; Phenylacetates; Prazosin; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Yohimbine	1984
P-1 purinoceptor antagonism by clonidine in the rat caecum. Life sciences, 1984, Jun-04, Volume: 34, Issue:23 Topics: Adenosine; Animals; Cecum; Clonidine; Dose-Response Relationship, Drug; Female; Guanfacine; Guanidines; In Vitro Techniques; Male; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, Purinergic	1984
Evidence against the involvement of a noradrenergic mechanism in the release by diazepam of novelty-induced hypophagia in rats. European journal of pharmacology, 1984, Apr-20, Volume: 100, Issue:2 Topics: Animals; Anxiety; Clonidine; Diazepam; Drug Interactions; Eating; Guanfacine; Guanidines; Humans; Male; Mice; Norepinephrine; Phenylacetates; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Yohimbine	1984
Guanfacine and clonidine: the effects on adrenal medullary function in spontaneously hypertensive rats. Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 272, Issue:1 Topics: Adrenal Glands; Adrenal Medulla; Animals; Blood Pressure; Catecholamines; Clonidine; Guanfacine; Guanidines; Heart Rate; Hypertension; Male; Phenylacetates; Rats; Rats, Inbred SHR; Time Factors	1984
Effects of clonidine and guanfacine on drinking and ambulation in spontaneously hypertensive rats. Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Drinking Behavior; Guanfacine; Guanidines; Hypertension; Kidney; Male; Motor Activity; Phenylacetates; Rats; Rats, Inbred Strains; Time Factors	1982
Effect of guanethidine, clonidine and guanfacine on urinary catecholamine excretion in cold-stressed spontaneously hypertensive rats. Japanese journal of pharmacology, 1982, Volume: 32, Issue:5 Topics: Animals; Antihypertensive Agents; Catecholamines; Clonidine; Cold Temperature; Guanethidine; Guanfacine; Guanidines; Hypertension; Male; Phenylacetates; Rats; Rats, Inbred Strains; Stress, Physiological	1982
Studies on clonidine and guanfacine withdrawal after short term treatment in the rat. Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Male; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors	1982
Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: investigation of the differences. British journal of pharmacology, 1982, Volume: 77, Issue:4 Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Chemistry; Cisterna Magna; Clonidine; Guanfacine; Guanidines; Heart Rate; Injections; Injections, Intravenous; Male; Phenylacetates; Rabbits; Salivation; Time Factors	1982
[Antihypertensive effect of guanfacine in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1981, Volume: 77, Issue:3 Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Consciousness; Decerebrate State; Electric Stimulation; Guanfacine; Guanidines; Heart Rate; Hypertension; Hypertension, Renal; Male; Phenylacetates; Rats; Rats, Inbred Strains; Respiration; Sympathetic Nervous System	1981
Haemodynamics in hypertensive patients before and during guanfacine treatment. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Output; Clonidine; Female; Guanfacine; Guanidines; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Phenylacetates; Physical Exertion; Stroke Volume; Vascular Resistance	1980
Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Antihypertensive Agents; Body Weight; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Guanfacine; Guanidines; Humans; Hypertension; Male; Middle Aged; Phenylacetates; Substance Withdrawal Syndrome; Time Factors; Xerostomia	1980
Effects of abrupt cessation of treatment with clonidine and guanfacine on blood pressure and heart rate in spontaneously hypertensive rats. Clinical and experimental hypertension, 1981, Volume: 3, Issue:1 Topics: Animals; Blood Pressure; Clonidine; Epinephrine; Guanfacine; Guanidines; Heart Rate; Hypertension; Male; Norepinephrine; Phenylacetates; Rats	1981
[Using the isolated atrial preparation of the guinea-pig and the canine heart lung preparation (HLP) supported by a donor, the effects of guanfacine on the heart, coronary circulation and myocardial energy metabolism were studied and compared with those o Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1980, Volume: 76, Issue:5 Topics: Animals; Clonidine; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Energy Metabolism; Female; Guanfacine; Guanidines; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Oxygen Consumption; Phenylacetates	1980
[Effects of guanfacine on the central nervous system (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1980, Volume: 76, Issue:7 Topics: Analgesics; Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Brain; Clonidine; Drug Synergism; Electroencephalography; Guanfacine; Guanidines; Hexobarbital; Male; Mice; Phenylacetates; Rats; Rectum; Sleep	1980
[Central hypotensive effects of guanfacine in anaesthetised rabbits (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1982, Volume: 79, Issue:4 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Desipramine; Guanfacine; Guanidines; Heart Rate; Hydroxydopamines; Injections, Intravenous; Injections, Intraventricular; Phentolamine; Phenylacetates; Rabbits	1982
Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 319, Issue:1 Topics: Animals; Antihypertensive Agents; Blood Pressure; Catheters, Indwelling; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Hypertension; Male; Phenylacetates; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome	1982
Effects of alpha-adrenoceptor agonists and antagonists on metabolic rate in cattle. Comparative biochemistry and physiology. Part A, Physiology, 1995, Volume: 111, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basal Metabolism; Body Temperature; Brimonidine Tartrate; Cattle; Clonidine; Dioxanes; Female; Guanfacine; Heart Rate; Idazoxan; Male; Prazosin; Quinoxalines	1995
The spinal analgesic role of alpha 2-adrenoceptor subtypes in rats after peripheral nerve section. European journal of pharmacology, 1994, Aug-01, Volume: 260, Issue:2-3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electrophysiology; Guanfacine; Injections, Spinal; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Sciatic Nerve	1994
The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesthesia and analgesia, 1993, Volume: 76, Issue:2 Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Guanfacine; In Vitro Techniques; Male; Nerve Block; Nerve Fibers; Neural Conduction; Rats; Sciatic Nerve	1993
Effects of alpha-2-adrenoceptor agonists on induced diuresis in rats. Life sciences, 1993, Volume: 53, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diuresis; Dose-Response Relationship, Drug; Guanabenz; Guanfacine; Male; Prazosin; Rats; Rats, Sprague-Dawley	1993
The effect of intrathecal guanfacine and clonidine on the flexor reflex in rats with intact and sectioned sciatic nerves. European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1 Topics: Analgesia; Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Female; Guanfacine; Injections, Spinal; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Up-Regulation	1993
The suppression of nightmares with guanfacine. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:8 Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Comorbidity; Depressive Disorder; Dreams; Drug Therapy, Combination; Female; Guanfacine; Humans; Rape; Sleep, REM; Stress Disorders, Post-Traumatic	1996
Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors. Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Azepines; Brimonidine Tartrate; Clonidine; Cognition; Discrimination, Psychological; Guanfacine; Haplorhini; Memory; Norepinephrine; Quinoxalines; Reaction Time; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Visual Perception	1998
Alpha-noradrenergic receptor modulation of the phencyclidine- and delta9-tetrahydrocannabinol-induced increases in dopamine utilization in rat prefrontal cortex. Synapse (New York, N.Y.), 1998, Volume: 28, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dopamine; Dopamine Uptake Inhibitors; Dronabinol; Guanfacine; Hallucinogens; Male; Nucleus Accumbens; Phencyclidine; Prazosin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha	1998
[Cardiovascular changes during alpha-2 agonist treatment of opiate withdrawal syndrome]. Revista clinica espanola, 1998, Volume: 198, Issue:4 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guanfacine; Heart Rate; Heroin; Heroin Dependence; Rats; Substance Withdrawal Syndrome; Time Factors	1998
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells. European journal of pharmacology, 1999, May-07, Volume: 372, Issue:1 Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Humans; Idazoxan; Isoquinolines; Neuroblastoma; Oxymetazoline; Piperazines; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Yohimbine	1999
Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Carbolines; Clonidine; GABA Antagonists; Guanfacine; Male; Memory; Memory Disorders; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Second Messenger Systems	2000
Alpha2A-adrenoceptor mediated tachypnea in awake goats. Respiration physiology, 2001, Volume: 125, Issue:3 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Goats; Guanfacine; Heart Rate; Idazoxan; Periodicity; Receptors, Adrenergic, alpha-2; Respiratory Mechanics	2001
Role of alpha 2-adrenoceptors and imidazoline receptors in the A5 region in the regulation of renal function in the rat. Proceedings of the Western Pharmacology Society, 2002, Volume: 45 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Guanfacine; Heart Rate; Imidazoles; Imidazoline Receptors; Kidney; Male; Pons; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Sodium; Urodynamics	2002
An antihypokinesic action of alpha2-adrenoceptors upon MPTP-induced behaviour deficits in mice. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Clonidine; Dopamine; Dopamine Agonists; Drug Interactions; Drug Therapy, Combination; Guanfacine; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neurons; Parkinsonian Disorders; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Yohimbine	2003
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists. European journal of pharmacology, 2003, Apr-25, Volume: 467, Issue:1-3 Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Enzyme Activation; Female; Guanfacine; In Vitro Techniques; Interleukin-12; Macrophages; Mice; Mice, Inbred DBA; Mitogen-Activated Protein Kinases; Oxymetazoline; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen	2003
The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors. Neuroscience, 2004, Volume: 126, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Anticonvulsants; Autoreceptors; Clonidine; Convulsants; Guanfacine; Mice; Mice, Knockout; Norepinephrine; Pentylenetetrazole; Receptors, Adrenergic, alpha-2; Seizures	2004
Clonidine and guanfacine-induced antinociception in visceral pain: possible role of alpha 2/I2 binding sites. European journal of pharmacology, 2004, Oct-06, Volume: 501, Issue:1-3 Topics: Analgesics; Animals; Binding Sites; Clonidine; Dose-Response Relationship, Drug; Guanfacine; Imidazoline Receptors; Male; Mice; Pain; Receptors, Adrenergic, alpha-2; Receptors, Drug; Visceral Afferents	2004
Noradrenergic alpha-2 agonists have anxiolytic-like actions on stress-related behavior and mesoprefrontal dopamine biochemistry. Brain research, 2004, Nov-19, Volume: 1027, Issue:1-2 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Behavior, Animal; Clonidine; Conditioning, Classical; Dopamine; Fear; Frontal Lobe; Guanfacine; Inhibition, Psychological; Male; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological	2004
Methylphenidate an effective treatment for ADHD? Journal of autism and developmental disorders, 2004, Volume: 34, Issue:5 Topics: Adrenergic alpha-Agonists; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Central Nervous System Stimulants; Child; Child Development Disorders, Pervasive; Clonidine; Diagnostic Errors; Guanfacine; Humans; Male; Medication Errors; Methylphenidate; Risperidone	2004
Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:8 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Guanfacine; Imidazoles; Male; Memory Disorders; Memory, Short-Term; Neurotransmitter Uptake Inhibitors; Phencyclidine; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Sex Factors; Spatial Behavior	2005
Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Psychopharmacology, 2005, Volume: 180, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Guanfacine; Imidazoles; Injections; Male; Medetomidine; Neural Inhibition; Piperazines; Prazosin; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-2; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Yohimbine	2005
G-protein-coupled alpha2A-adrenoreceptor agonists differentially alter citrus leaf and fruit abscission by affecting expression of ACC synthase and ACC oxidase. Journal of experimental botany, 2005, Volume: 56, Issue:417 Topics: Adrenergic alpha-2 Receptor Agonists; Amino Acid Oxidoreductases; Citrus; Clonidine; Fruit; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Guanfacine; Lyases; Organophosphorus Compounds; Plant Growth Regulators; Plant Leaves; Pyrazoles	2005
New developments in the treatment of ADHD. The Journal of clinical psychiatry, 2006, Volume: 67, Issue:1 Topics: Antidepressive Agents, Tricyclic; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Child; Clonidine; Cognitive Behavioral Therapy; Guanfacine; Humans; Modafinil; Nicotinic Agonists; Physician's Role; Primary Health Care; Propylamines; Treatment Outcome	2006
Alpha 2A-adrenoceptor-specific stimulation of [35S]GTP gamma S binding to membrane preparations of rat frontal cortex. Neurochemical research, 2008, Volume: 33, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Clonidine; Emotions; Guanfacine; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoquinolines; Kinetics; Membranes; Naphthyridines; Prefrontal Cortex; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Signal Transduction; Stress, Psychological	2008
Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:9 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bacterial Proteins; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Guanfacine; In Vitro Techniques; Neural Inhibition; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Repressor Proteins; Suramin; Yohimbine	2008
Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors. Neuropharmacology, 2008, Volume: 54, Issue:6 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Brimonidine Tartrate; Clonidine; Data Interpretation, Statistical; Electric Stimulation; Enkephalins; Guanfacine; Immunohistochemistry; Male; Medetomidine; Microscopy, Confocal; Oligopeptides; Protease Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Veratridine	2008
Partial agonism at the human alpha(2A)-autoreceptor: role of binding duration. Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:1 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Autoreceptors; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Female; Guanfacine; Humans; In Vitro Techniques; Infant; Male; Middle Aged; Neocortex; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Temperature; Time Factors; Young Adult	2008
Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain research, 2008, Dec-30, Volume: 1246 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Disease Models, Animal; Dopamine; Guanfacine; Imidazoles; Isoindoles; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Schizophrenia	2008
Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. The Journal of biological chemistry, 2009, May-08, Volume: 284, Issue:19 Topics: Adrenergic alpha-Agonists; Animals; Blotting, Southern; Brain; Calcium; Cells, Cultured; Clonidine; Electrophysiology; Endocytosis; Fluorescent Antibody Technique; GTP-Binding Proteins; Guanfacine; Guanosine 5'-O-(3-Thiotriphosphate); Hemagglutinins; Humans; Immunoenzyme Techniques; Integrases; Kidney; Male; Mice; Mice, Inbred C57BL; Neurons; Norepinephrine; Phosphorylation; Protein Binding; Receptors, Adrenergic, alpha-2; Signal Transduction; Sympathetic Nervous System; Transfection	2009
In the pipeline: non-stimulant ADHD meds. Behavioral healthcare, 2010, Volume: 30, Issue:1 Topics: Adrenergic alpha-Agonists; Attention Deficit Disorder with Hyperactivity; Clonidine; Guanfacine; Humans	2010
α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking. Biological psychiatry, 2011, Oct-15, Volume: 70, Issue:8 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Cues; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Guanfacine; Imidazoles; Imidazoline Receptors; Isoquinolines; Male; Motor Activity; Naphthyridines; Prazosin; Propranolol; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration	2011
Treatment patterns, adherence, and persistence in ADHD: a Canadian perspective. Postgraduate medicine, 2012, Volume: 124, Issue:3 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clonidine; Cross-Sectional Studies; Drug Prescriptions; Drug Utilization Review; Female; Guanfacine; Humans; Male; Patient Compliance; Propylamines; Quebec; Retrospective Studies	2012
Adjuvants to prolong the local anesthetic effects of coated microneedle products. International journal of pharmaceutics, 2012, Dec-15, Volume: 439, Issue:1-2 Topics: Adjuvants, Pharmaceutic; Anesthetics, Local; Animals; Clonidine; Female; Guanfacine; Lidocaine; Microinjections; Needles; Prilocaine; Skin; Swine	2012
Effects of FDA advisories on the pharmacologic treatment of ADHD, 2004-2008. Psychiatric services (Washington, D.C.), 2013, Apr-01, Volume: 64, Issue:4 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimulants; Child; Clonidine; Dopamine Uptake Inhibitors; Drug Utilization; Guanfacine; Humans; Practice Patterns, Physicians'; Propylamines; United States; United States Food and Drug Administration	2013
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System. The Journal of pediatrics, 2014, Volume: 164, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanfacine; Humans; Hypotension; Incidence; Male; Poison Control Centers; Poisoning; Population Surveillance; Retrospective Studies; Survival Rate; United States	2014
Stimulation of postsynapse adrenergic α2A receptor improves attention/cognition performance in an animal model of attention deficit hyperactivity disorder. Behavioural brain research, 2014, Aug-15, Volume: 270 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Clonidine; Cognition; Disease Models, Animal; Guanfacine; Inhibition, Psychological; Male; Neuropsychological Tests; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Treatment Outcome	2014
Noradrenergic modulation of risk/reward decision making. Psychopharmacology, 2015, Volume: 232, Issue:15 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Behavior, Animal; Choice Behavior; Clonidine; Conditioning, Operant; Decision Making; Guanfacine; Male; Probability; Rats; Rats, Long-Evans; Reward; Risk; Risk-Taking; Yohimbine	2015
A cost-effectiveness analysis of off-label atypical antipsychotic treatment in children and adolescents with ADHD who have failed stimulant therapy. Attention deficit and hyperactivity disorders, 2016, Volume: 8, Issue:3 Topics: Adolescent; Antipsychotic Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; Cost-Benefit Analysis; Decision Support Techniques; Guanfacine; Health Care Costs; Humans; Monte Carlo Method; Quality-Adjusted Life Years; Treatment Failure	2016
Treating ADHD in Prison: Focus on Alpha-2 Agonists (Clonidine and Guanfacine). The journal of the American Academy of Psychiatry and the Law, 2016, Volume: 44, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Attention Deficit Disorder with Hyperactivity; Clonidine; Guanfacine; Humans; Prisoners; United States; United States Food and Drug Administration	2016
Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine. PloS one, 2016, Volume: 11, Issue:7 Topics: Adrenergic Agonists; Animals; Ascites; Canrenoic Acid; Clonidine; Diuretics; Drug Synergism; Fibrosis; Furosemide; Guanfacine; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2	2016
Pharmacotherapy of Attention Deficit Hyperactivity Disorder Symptom Profile in ASD. The Journal of nervous and mental disease, 2017, Volume: 205, Issue:9 Topics: Aripiprazole; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Clonidine; Comorbidity; Cross-Sectional Studies; Guanfacine; Humans; Methylphenidate; Randomized Controlled Trials as Topic; Risperidone; Social Adjustment; Treatment Outcome	2017
Treating Hypertension During Breastfeeding. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2018, Volume: 13, Issue:2 Topics: Adult; Antihypertensive Agents; Breast Feeding; Clonidine; Contraindications; Female; Guanfacine; Guidelines as Topic; Humans; Hypertension; Infant, Newborn; Mothers	2018
Alpha Clinical & experimental optometry, 2019, Volume: 102, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Axial Length, Eye; Brimonidine Tartrate; Chickens; Clonidine; Disease Models, Animal; Guanfacine; Intravitreal Injections; Male; Myopia; Sensory Deprivation; Yohimbine	2019