clonidine has been researched along with enkephalin, leucine in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (54.41) | 18.7374 |
| 1990's | 30 (44.12) | 18.2507 |
| 2000's | 1 (1.47) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH | 1 |
| Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, D | 1 |
| Hylden, JK; Kitto, K; Lei, S; Roerig, SC; Wilcox, GL | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 1 |
| Johnson, SM | 1 |
| Dubner, R; Hylden, JL; Iadarola, MJ; Nahin, RL; Thomas, DA | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Arts, KS; Fujimoto, J; Rady, J; Tseng, L | 1 |
| Arts, KS; Fujimoto, JM; Rady, JJ; Tseng, LF | 1 |
| Amerini, S; Ledda, F; Mantelli, L | 1 |
| Arts, KS; Fujimoto, JM; Holmes, BB | 1 |
| Green, J; Harris, S; Lloyd, P; Lozito, R; Messineo, E; Ossipov, MH | 1 |
| Diehl, J; Kokorsch, F; Kolloch, R; Kraft, K; Stumpe, KO | 2 |
| Mulder, AH; Schoffelmeer, AN; Wierenga, EA | 1 |
| Kolloch, R; Kraft, K; Stumpe, KO; Theobald, R | 1 |
| Beitner, DB; Duman, RS; Nestler, EJ | 1 |
| Stevens, CW; Yaksh, TL | 1 |
| Abbott, FV; Kunos, G; Mastrianni, JA | 1 |
| Kunos, G; Mosqueda-Garcia, R | 1 |
| Chuang, DM; Zhu, XZ | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Lefebvre, R | 1 |
| Florijn, WJ; Versteeg, DH | 1 |
| Keith, RA; Salama, AI | 1 |
| De Léan, A; Nguyen, TT | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; McWilliam, JR | 2 |
| Eskay, R; Kunos, G; Mosqueda-Garcia, R; Palkovits, M; Zamir, N | 1 |
| Chandra, A; Diliberto, EJ; Dixon, WR; Holaday, JW; Lewis, JW; Long, JB; Tortella, FC; Unsworth, CD; Viveros, OH; Way, EL | 1 |
| Berry-Kravis, E; Dawson, G | 2 |
| Aghajanian, GK; Freedman, JE | 1 |
| Gershow, J; Krames, ES; Wilkie, DJ | 1 |
| Mulder, AH; Putters, J; Schoffelmeer, AN | 1 |
| Gaida, W; Ganten, D; Kraft, K; Lang, RE; Unger, T | 1 |
| Ferreira, SH; Nakamura, M | 1 |
| Dandekar, T; Gramsch, C; Metzner, K; Schulz, R | 1 |
| Bueno, L; Primi, MP | 1 |
| Coombs, DW; Jensen, LE; Lachance, D; Ragnarsson, TS; Saunders, RL; Savage, S | 1 |
| Golembiowska-Nikitin, K; Pilc, A; Vetulani, J | 1 |
| Hiroto, S; Imura, H; Katakami, H; Kato, Y; Matsushita, N; Shimatsu, A | 1 |
| Agnoli, A; Ceci, E; Denaro, A; Falaschi, P | 1 |
| Dawson, G; Louie, AK | 1 |
| Livingston, A; Morris, B | 1 |
| Huang, YH; Redmond, DE | 1 |
| Giles, TD; Sander, GE | 1 |
| Krystal, JH; Redmond, DE | 1 |
| Belluzzi, O; Perri, V; Simpatico, TA | 1 |
| Medvedev, OS | 1 |
| Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K | 1 |
| Galligan, JJ | 1 |
| Paul, D; Tran, JG | 1 |
| Barturen, F; Gabilondo, AM; García-Sevilla, JA; Meana, JJ; Sastre, M | 1 |
| Chapman, IM; Kapoor, R; Willoughby, JO | 1 |
| Zheng, X | 1 |
| Ding, H; Wang, C; Zhang, T; Zheng, X | 1 |
| Feldman, JL; Johnson, SM; Smith, JC | 1 |
| Englberger, W; Friderichs, E; Hennies, HH; Reimann, W; Selve, N; Wilffert, B | 1 |
| Aley, KO; Levine, JD | 1 |
| Bian, D; Lopez, Y; Nichols, ML; Ossipov, MH; Porreca, F | 1 |
| Berkmiller, G; Falk, W; Frauenholz, T; Herrmann, M; Lang, B; Schölmerich, J; Straub, RH | 1 |
| Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT | 1 |
| Budai, D; Fields, HL | 1 |
| Abysique, A; Bouvier, M; Orsoni, P | 1 |
| Cutler, DJ; Mason, R; Mundey, MK | 1 |
| Chen, W; Marvizón, JC; Song, B | 1 |
1 review(s) available for clonidine and enkephalin, leucine
| Article | Year |
|---|---|
Multiple mechanisms of withdrawal from opioid drugs.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Conditioning, Psychological; Cyclic GMP; Dopamine; Drug Tolerance; Enkephalins; Fear; gamma-Aminobutyric Acid; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Norepinephrine; Protein Conformation; Receptors, Opioid; Serotonin; Substance Withdrawal Syndrome | 1984 |
67 other study(ies) available for clonidine and enkephalin, leucine
| Article | Year |
|---|---|
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Male; Muscle Contraction; Neuropeptide Y; Potassium Channels; Pyrroles; Scorpion Venoms; Synaptic Transmission; Trachea | 1992 |
The pressor response to central administration of beta-endorphin results from a centrally mediated increase in noradrenaline release and adrenaline secretion.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Naloxone; Norepinephrine; Rabbits | 1991 |
Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.
Topics: Adenosine Triphosphatases; Animals; Apamin; Bronchi; Bronchoconstriction; Calcium; Cation Transport Proteins; Charybdotoxin; Clonidine; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glyburide; In Vitro Techniques; Ion Channel Gating; Male; Neural Inhibition; Neurons, Afferent; Neuropeptide Y; Potassium Channels; Pyrrolidines; Scorpion Venoms | 1992 |
Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1992 |
Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn.
Topics: Adrenergic alpha-Agonists; Animals; Anterior Horn Cells; Cats; Clonidine; Drug Interactions; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Nonspecific tolerance in ileal circular muscle-myenteric plexus preparations from morphine-pretreated guinea pigs.
Topics: 2-Chloroadenosine; Animals; Clonidine; Drug Tolerance; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Myenteric Plexus; Receptors, Opioid | 1991 |
Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Carrageenan; Clonidine; Enkephalins; Hyperalgesia; Inflammation; Male; Morphine; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1991 |
Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.
Topics: Analgesia; Animals; beta-Endorphin; Cerebral Ventricles; Cholera Toxin; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Morphine; Narcotics; Pain; Pertussis Toxin; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1991 |
Intracerebroventricular analgesia enhanced by intrathecal (IT) dynorphin A(1-17) antibody.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Physostigmine; Pyrrolidines | 1990 |
Spinal dynorphin A (1-17): possible mediator of antianalgesic action.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptors; Physostigmine; Pyrrolidines; Spinal Cord | 1990 |
Opioid agonists, prostaglandin E1 and clonidine modulate non-adrenergic, non-cholinergic transmission in the mammalian heart.
Topics: Adrenergic beta-Antagonists; Alprostadil; Animals; Atrial Function; Capsaicin; Clonidine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Morphine; Myocardial Contraction; Nerve Fibers | 1990 |
Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Morphine; Serotonin; Yohimbine | 1991 |
Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis.
Topics: Analgesics; Animals; Benzeneacetamides; Clonidine; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Regression Analysis; Spinal Cord | 1990 |
Altered plasma leucine-enkephalin concentrations in patients with established hypertension.
Topics: Adult; Blood Pressure; Clonidine; Enkephalin, Leucine; Exercise; Feedback; Humans; Hypertension; Male; Norepinephrine; Sympathetic Nervous System | 1990 |
Role of adenylate cyclase in presynaptic alpha 2-adrenoceptor- and mu-opioid receptor-mediated inhibition of [3H]noradrenaline release from rat brain cortex slices.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Bucladesine; Cadmium; Calcimycin; Cerebral Cortex; Clonidine; Colforsin; Cyclic AMP; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Morphine; Norepinephrine; Phentolamine; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Rolipram | 1986 |
Normalization of blood pressure and plasma concentrations of beta-endorphin and leucine-enkephalin in patients with primary hypertension after treatment with clonidine.
Topics: Adult; beta-Endorphin; Blood Pressure; Clonidine; Enkephalin, Leucine; Humans; Hydrocortisone; Hypertension; Male; Norepinephrine; Radioimmunoassay; Renin | 1987 |
A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP-Binding Proteins; Locus Coeruleus; Male; Morphine; Naloxone; Opioid-Related Disorders; Rats; Rats, Inbred Strains | 1989 |
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Infusions, Parenteral; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reference Values; Sufentanil | 1989 |
Activation of central mu-opioid receptors is involved in clonidine analgesia in rats.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Species Specificity | 1989 |
Altered plasma leucine-enkephalin concentrations in patients with established hypertension may be involved in impaired regulation of blood pressure.
Topics: Adult; Blood Pressure; Clonidine; Enkephalin, Leucine; Exercise Test; Humans; Hypertension; Male; Norepinephrine | 1989 |
Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.
Topics: Animals; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Heart Rate; Hypertension; Male; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Differential regulation by butyrate and dibutyryl cyclic AMP of delta-opioid, alpha 2-adrenergic, and muscarinic cholinergic receptors in NCB-20 cells.
Topics: Alprostadil; Animals; Binding, Competitive; Brain; Bucladesine; Butyrates; Butyric Acid; Carbachol; Clonidine; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phosphatidylinositols; Quinuclidinyl Benzilate; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Receptors, Opioid, delta; Tumor Cells, Cultured | 1988 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
[In vitro study of the non-adrenergic non-cholinergic innervation of the rat and cat stomach].
Topics: Animals; Cats; Clonidine; Electric Stimulation; Enkephalins; Female; Gastric Fundus; In Vitro Techniques; Male; Morphine; Muscle Relaxation; Neurotransmitter Agents; Rats; Stomach | 1986 |
Phorbol 12,13-dibutyrate enhances electrically stimulated neuromessenger release from rat dorsal hippocampal slices in vitro.
Topics: Acetylcholine; Animals; Carbachol; Clonidine; Electric Stimulation; Enkephalin, Leucine; Hippocampus; In Vitro Techniques; Male; Neurotransmitter Agents; Norepinephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Rats; Rats, Inbred Strains; Serotonin; Yohimbine | 1987 |
Inhibition of presynaptic alpha-2-adrenoceptor and opioid receptor agonist responses in the rat vas deferens by chronic imipramine treatment.
Topics: Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Imipramine; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Parasympathomimetics; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin; Vas Deferens | 1987 |
Nonadrenergic modulation by clonidine of the cosecretion of catecholamines and enkephalins in adrenal chromaffin cells.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Animals; Catecholamines; Cattle; Cells, Cultured; Clonidine; Enkephalin, Leucine; Epinephrine; Nicotine; Norepinephrine; Receptors, Adrenergic, alpha; Reserpine | 1987 |
Synaptosomal free [Ca2+] is reduced by clonidine and dynorphin A-(1-13) and increased by idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Calcium; Clonidine; Dioxanes; Dioxins; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Idazoxan; In Vitro Techniques; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1987 |
Mutual antagonism of kappa-opiate and alpha 2-adrenoceptor agonist effects on intrasynaptosomal free [Ca2+]i.
Topics: Aminoquinolines; Animals; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fluorescent Dyes; Idazoxan; Male; Morphine; Naloxone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes | 1988 |
Opioid-mediated cardiovascular effects of clonidine in spontaneously hypertensive rats: elimination by neonatal treatment with monosodium glutamate.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Blood Pressure; Clonidine; Endorphins; Enkephalin, Leucine; Glutamates; Heart Rate; Hemodynamics; Hypertension; Medulla Oblongata; Naloxone; Naltrexone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Glutamate | 1986 |
Multiple opiate receptors: functional implications.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Azocines; Behavior, Animal; Binding Sites; Blood Pressure; Clonidine; Corticosterone; Enkephalins; Naloxone; Receptors, Opioid; Stress, Physiological; Sympathetic Nervous System | 1985 |
Evidence for [D-Ala2,D-Leu5]enkephalin-induced supersensitivity to 5-hydroxytryptamine in a neurotumor x brain hybrid cell line (NCB-20).
Topics: Adenylyl Cyclases; Alprostadil; Animals; Brain; Brain Chemistry; Cell Line; Cholera Toxin; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Mice; Neuroblastoma; Receptors, Serotonin; Serotonin | 1985 |
Opiate and alpha 2-adrenoceptor responses of rat amygdaloid neurons: co-localization and interactions during withdrawal.
Topics: Amygdala; Animals; Clonidine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Iontophoresis; Male; Microelectrodes; Morphine; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1985 |
Intrathecal D-Ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate.
Topics: Aged; Carcinoma; Clonidine; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Injections, Spinal; Male; Morphine; Naloxone; Pain, Intractable; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Skull Neoplasms; Spinal Neoplasms; Substance Withdrawal Syndrome; Thyroid Neoplasms | 1986 |
Activation of presynaptic alpha 2-adrenoceptors attenuates the inhibitory effect of mu-opioid receptor agonists on noradrenaline release from brain slices.
Topics: Animals; Brain Chemistry; Cadmium; Clonidine; Colforsin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Morphine; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu | 1986 |
Altered neuropeptide concentrations in spontaneously hypertensive rats: cause or consequence?
Topics: Animals; Arginine Vasopressin; beta-Endorphin; Brain; Clonidine; Endorphins; Enkephalin, Leucine; Hypertension; Male; Nerve Tissue Proteins; Oxytocin; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1985 |
Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances.
Topics: Analgesics; Animals; Carrageenan; Clonidine; Dinoprostone; Drug Tolerance; Enkephalins; Male; Morphine; Naloxone; Peripheral Nerves; Prostaglandins E; Rats; Rats, Inbred Strains; Yohimbine | 1988 |
Opiates induce long-term increases in prodynorphin-derived peptide levels in the guinea-pig myenteric plexus.
Topics: Animals; Clonidine; Dextrorphan; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Ileum; Levorphanol; Male; Mice; Myenteric Plexus; Narcotic Antagonists; Narcotics; Peptides; Protein Precursors | 1986 |
Effects of centrally administered naloxone on gastrointestinal myoelectrical activity in morphine-dependent rats.
Topics: Animals; Atropine; Clonidine; Digestive System; Electrophysiology; Enkephalin, Leucine; Gastrointestinal Motility; Indomethacin; Injections, Intraventricular; Injections, Subcutaneous; Male; Methysergide; Morphine; Naloxone; Phentolamine; Rats; Substance-Related Disorders; Tolazoline | 1987 |
Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine.
Topics: Adenocarcinoma; Bupivacaine; Clonidine; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Infusions, Parenteral; Injections, Intraventricular; Injections, Spinal; Middle Aged; Morphine; Nerve Block; Pain, Intractable; Pelvic Neoplasms; Terminal Care | 1985 |
Opiates and specific receptor binding of [3H]clonidine.
Topics: Animals; Binding, Competitive; Clonidine; Enkephalins; In Vitro Techniques; Morphine; Naloxone; Narcotics; Rats; Receptors, Drug | 1980 |
Involvement of alpha-adrenergic mechanisms in growth hormone release induced by opioid peptides in conscious rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; beta-Endorphin; Clonidine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Ditiocarb; Endorphins; Enkephalins; Growth Hormone; Hormones; Male; Rats; Rats, Inbred Strains; Reserpine | 1981 |
On the etiopathogenesis of migraine: a possible link between the amines and endorphin hypotheses.
Topics: Adult; Clonidine; Dopamine; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Histamine; Humans; Male; Middle Aged; Migraine Disorders; Neurotransmitter Agents; Norepinephrine; Pain; Premedication; Prolactin; Sensory Thresholds; Serotonin; Substance Withdrawal Syndrome | 1982 |
Gangliosides as modulators of the coupling of neurotransmitters to adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gangliosides; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Neurons; Neurotransmitter Agents; Receptors, Serotonin | 1984 |
Effects of opiate and alpha 2-adrenergic agonists in a neuroblastoma x brain explant hybrid cell line (NCB-20).
Topics: Adrenergic alpha-Agonists; Alprostadil; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Mice; Narcotics; Neuroblastoma; Neurons; Prostaglandins E | 1984 |
Binding of [3H]clonidine to membranes from cow neurohypophysis and cerebral cortex of the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Clonidine; Cyclazocine; Enkephalin, Leucine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Membranes; Morphine; Naloxone; Narcotics; Pituitary Gland, Posterior; Rats | 1984 |
The primate locus coeruleus and effects of clonidine on opiate withdrawal.
Topics: Animals; Behavior, Animal; Clonidine; Electric Stimulation; Enkephalins; Fear; Humans; Locus Coeruleus; Macaca; Morphine; Naloxone; Norepinephrine; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 1982 |
Interactions of leucine-enkephalin with alpha-adrenoceptors in the conscious dog.
Topics: Animals; Blood Pressure; Chemoreceptor Cells; Clonidine; Consciousness; Dogs; Enkephalin, Leucine; Heart Rate; Naloxone; Prazosin; Pressoreceptors; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1983 |
[Acetylcholine release in superior cervical ganglia in the guinea pig by the use of tritiated choline].
Topics: Acetylcholine; Animals; Choline; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalins; Ganglia, Sympathetic; Guinea Pigs; Norepinephrine; Tritium | 1982 |
Opiate mechanisms in the regulation of the cardiovascular system.
Topics: Animals; Cats; Clonidine; Enkephalins; Hemodynamics; Hypertension; Naloxone; Rats; Rats, Inbred Strains | 1982 |
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Colon; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
Differential cross-tolerance between analgesia produced by alpha 2-adrenoceptor agonists and receptor subtype selective opioid treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Binding Sites; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Xylazine | 1995 |
mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Amino Acid Sequence; Analgesics; Brain Chemistry; Chronic Disease; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Heroin Dependence; Humans; Male; Molecular Sequence Data; Radioligand Assay; Receptors, Opioid, mu | 1994 |
Interactions between the effects of opioid, serotonin and alpha-2-adrenergic receptor agonists on growth hormone release in the male rat. Intrahypothalamic administration.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dioxanes; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Growth Hormone; Hypothalamus; Idazoxan; Injections; Male; Quipazine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Serotonin | 1993 |
[Changes in plasma neuropeptides before and after clonidine in patients with essential hypertension].
Topics: Adult; Aged; beta-Endorphin; Blood Pressure; Clonidine; Enkephalin, Leucine; Female; Humans; Hypertension; Male; Middle Aged; Neuropeptides; Renin | 1993 |
Plasma levels of beta-endorphin, leucine enkephalin and arginine vasopressin in patients with essential hypertension and the effects of clonidine.
Topics: Angiotensin II; Antihypertensive Agents; Arginine Vasopressin; beta-Endorphin; Blood Pressure; Clonidine; Enkephalin, Leucine; Female; Heart Rate; Humans; Hypertension; Injections, Intravenous; Male; Middle Aged; Naloxone; Narcotic Antagonists; Neurotensin; Renin; Time Factors | 1995 |
Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms.
Topics: Analgesics; Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; GTP-Binding Proteins; In Vitro Techniques; Rats; Respiration; Serotonin | 1996 |
Galanin receptor antagonists attenuate spinal antinociceptive effects of DAMGO, tramadol and non-opioid drugs in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Tramadol | 1996 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine | 1997 |
Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Injections, Spinal; Male; Morphine; Pain; Phentolamine; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots | 1997 |
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics; Animals; beta-Endorphin; Clonidine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Interleukin-6; Isoproterenol; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Narcotic Antagonists; Neurons; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid; Spleen | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
Evidence for supraspinal nervous control of external anal sphincter motility in the cat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anal Canal; Animals; Blood Pressure; Brimonidine Tartrate; Cats; Clonidine; Efferent Pathways; Electric Stimulation; Electromyography; Enkephalin, Leucine; Female; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Locus Coeruleus; Male; Morphine; Narcotics; Nicergoline; Norepinephrine; Peripheral Nerves; Phenylephrine; Prazosin; Quinoxalines; Reflex; Spinal Cord | 1998 |
Electrophysiological effects of opioid receptor activation on Syrian hamster suprachiasmatic nucleus neurones in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Suprachiasmatic Nucleus; Time Factors | 1999 |
Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Brimonidine Tartrate; Clonidine; Data Interpretation, Statistical; Electric Stimulation; Enkephalins; Guanfacine; Immunohistochemistry; Male; Medetomidine; Microscopy, Confocal; Oligopeptides; Protease Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Veratridine | 2008 |