clonidine has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.88) | 18.7374 |
| 1990's | 22 (64.71) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boettcher, C; Bünemann, M; Dees, C; Lohse, MJ; Nikolaev, VO; Zenk, MH | 1 |
| Castro, LM; Dale, CS; de Souza, LL; Devi, LA; Ferro, ES; Giorgi, R; Gomes, I; Gupta, A; Heimann, AS; Luchessi, AD; Pagano, RL; Rioli, V | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH | 1 |
| Mathias, CJ; May, CN; Whitehead, CJ | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, D | 1 |
| Hylden, JK; Kitto, K; Lei, S; Roerig, SC; Wilcox, GL | 1 |
| Collins, JG; Kitahata, LM; Nakagawa, I; Nakatani, K; Omote, K | 1 |
| Johnson, SM | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Arts, KS; Fujimoto, J; Rady, J; Tseng, L | 1 |
| Arts, KS; Fujimoto, JM; Rady, JJ; Tseng, LF | 1 |
| Amerini, S; Ledda, F; Mantelli, L | 1 |
| Arts, KS; Fujimoto, JM; Holmes, BB | 1 |
| Stevens, CW; Yaksh, TL | 1 |
| Geppert, M; Illes, P; Jackisch, R | 1 |
| Galligan, JJ | 1 |
| Paul, D; Tran, JG | 1 |
| Barturen, F; Gabilondo, AM; García-Sevilla, JA; Meana, JJ; Sastre, M | 1 |
| Chapman, IM; Kapoor, R; Willoughby, JO | 1 |
| Feldman, JL; Johnson, SM; Smith, JC | 1 |
| Englberger, W; Friderichs, E; Hennies, HH; Reimann, W; Selve, N; Wilffert, B | 1 |
| Aley, KO; Levine, JD | 1 |
| Bian, D; Lopez, Y; Nichols, ML; Ossipov, MH; Porreca, F | 1 |
| Berkmiller, G; Falk, W; Frauenholz, T; Herrmann, M; Lang, B; Schölmerich, J; Straub, RH | 1 |
| Ingram, S; McCleskey, EW; Wilding, TJ; Williams, JT | 1 |
| Budai, D; Fields, HL | 1 |
| Al-Khrasani, M; Elor, G; Rónai, AZ; Yusuf Abbas, M | 1 |
| Mollereau, C; Roumy, M; Zajac, JM | 1 |
| Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 1 |
| Gyires, K; Zádori, Z | 1 |
| Evans, CJ; Tan, M; Walwyn, WM; Xie, CW | 1 |
| Beitz, AJ; Han, HJ; Lee, JH; Roh, DH; Seo, HS; Song, S; Yoon, SY | 1 |
| Chabot-Doré, AJ; Millecamps, M; Stone, LS | 1 |
| Carayon, K; Combedazou, A; Haanappel, E; Mazères, S; Mollereau, C; Moulédous, L; Salomé, L | 1 |
34 other study(ies) available for clonidine and enkephalin, ala(2)-mephe(4)-gly(5)-
| Article | Year |
|---|---|
Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.
Topics: Cells, Cultured; Fluorescence Resonance Energy Transfer; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Receptors, Opioid, mu | 2007 |
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
Topics: Cell Line; Drug Inverse Agonism; Hemoglobins; Humans; Ligands; Peptide Fragments; Receptor, Cannabinoid, CB1 | 2007 |
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Male; Muscle Contraction; Neuropeptide Y; Potassium Channels; Pyrroles; Scorpion Venoms; Synaptic Transmission; Trachea | 1992 |
The pressor response to central administration of beta-endorphin results from a centrally mediated increase in noradrenaline release and adrenaline secretion.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Injections, Intraventricular; Male; Naloxone; Norepinephrine; Rabbits | 1991 |
Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.
Topics: Adenosine Triphosphatases; Animals; Apamin; Bronchi; Bronchoconstriction; Calcium; Cation Transport Proteins; Charybdotoxin; Clonidine; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glyburide; In Vitro Techniques; Ion Channel Gating; Male; Neural Inhibition; Neurons, Afferent; Neuropeptide Y; Potassium Channels; Pyrrolidines; Scorpion Venoms | 1992 |
Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Behavior, Animal; Clonidine; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1992 |
Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn.
Topics: Adrenergic alpha-Agonists; Animals; Anterior Horn Cells; Cats; Clonidine; Drug Interactions; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Spinal; Male; Naloxone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Nonspecific tolerance in ileal circular muscle-myenteric plexus preparations from morphine-pretreated guinea pigs.
Topics: 2-Chloroadenosine; Animals; Clonidine; Drug Tolerance; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Myenteric Plexus; Receptors, Opioid | 1991 |
Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.
Topics: Analgesia; Animals; beta-Endorphin; Cerebral Ventricles; Cholera Toxin; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Morphine; Narcotics; Pain; Pertussis Toxin; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1991 |
Intracerebroventricular analgesia enhanced by intrathecal (IT) dynorphin A(1-17) antibody.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Physostigmine; Pyrrolidines | 1990 |
Spinal dynorphin A (1-17): possible mediator of antianalgesic action.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptors; Physostigmine; Pyrrolidines; Spinal Cord | 1990 |
Opioid agonists, prostaglandin E1 and clonidine modulate non-adrenergic, non-cholinergic transmission in the mammalian heart.
Topics: Adrenergic beta-Antagonists; Alprostadil; Animals; Atrial Function; Capsaicin; Clonidine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Heart; Heart Atria; Imidazoles; In Vitro Techniques; Morphine; Myocardial Contraction; Nerve Fibers | 1990 |
Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice.
Topics: Analgesia; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Morphine; Serotonin; Yohimbine | 1991 |
Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.
Topics: Analgesics; Animals; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Infusions, Parenteral; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Reference Values; Sufentanil | 1989 |
Characterization of opioid receptors modulating noradrenaline release in the hippocampus of the rabbit.
Topics: Animals; Benzomorphans; Clonidine; Cyclazocine; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Hippocampus; Morphine; Norepinephrine; Rabbits; Receptors, Opioid | 1986 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
Differential cross-tolerance between analgesia produced by alpha 2-adrenoceptor agonists and receptor subtype selective opioid treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Binding Sites; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Xylazine | 1995 |
mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Amino Acid Sequence; Analgesics; Brain Chemistry; Chronic Disease; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Heroin Dependence; Humans; Male; Molecular Sequence Data; Radioligand Assay; Receptors, Opioid, mu | 1994 |
Interactions between the effects of opioid, serotonin and alpha-2-adrenergic receptor agonists on growth hormone release in the male rat. Intrahypothalamic administration.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dioxanes; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Growth Hormone; Hypothalamus; Idazoxan; Injections; Male; Quipazine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Serotonin | 1993 |
Modulation of respiratory rhythm in vitro: role of Gi/o protein-mediated mechanisms.
Topics: Analgesics; Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; GTP-Binding Proteins; In Vitro Techniques; Rats; Respiration; Serotonin | 1996 |
Galanin receptor antagonists attenuate spinal antinociceptive effects of DAMGO, tramadol and non-opioid drugs in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Tramadol | 1996 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine | 1997 |
Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Injections, Spinal; Male; Morphine; Pain; Phentolamine; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots | 1997 |
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analgesics; Animals; beta-Endorphin; Clonidine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Interleukin-6; Isoproterenol; Mice; Mice, Inbred Strains; Morphinans; Naloxone; Narcotic Antagonists; Neurons; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid; Spleen | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
The effect of endomorphins on the release of 3H-norepinephrine from rat nucleus tractus solitarii slices.
Topics: Analgesics, Opioid; Animals; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Motor Neurons; Norepinephrine; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, mu; Solitary Nucleus; Tritium; Vagus Nerve | 2003 |
Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors.
Topics: Calcium; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Neuroblastoma; Neuropeptide Y; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid; Staurosporine | 2007 |
Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Anticonvulsants; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gabapentin; gamma-Aminobutyric Acid; Idazoxan; Neuralgia; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord | 2008 |
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer | 2008 |
p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Calcium; Cells, Cultured; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Ion Channel Gating; Mice; Mice, Knockout; Morphine; Neurons; Neurotransmitter Agents; p38 Mitogen-Activated Protein Kinases; Protein Transport; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu | 2009 |
Activation of spinal alpha-2 adrenoceptors, but not mu-opioid receptors, reduces the intrathecal N-methyl-D-aspartate-induced increase in spinal NR1 subunit phosphorylation and nociceptive behaviors in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Immunohistochemistry; Injections, Spinal; Male; N-Methylaspartate; Pain; Phosphorylation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2010 |
The delta-opioid receptor is sufficient, but not necessary, for spinal opioid-adrenergic analgesic synergy.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Spinal; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P | 2013 |
Heterologous regulation of Mu-opioid (MOP) receptor mobility in the membrane of SH-SY5Y cells.
Topics: Analgesics, Opioid; Cell Line, Tumor; Cell Membrane; Clonidine; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Gene Expression Regulation; Humans; Neurons; Neuropeptide Y; Oligopeptides; Protein Multimerization; Protein Transport; Receptor Cross-Talk; Receptors, Adrenergic, alpha-2; Receptors, Neuropeptide; Receptors, Opioid, mu; Signal Transduction | 2014 |