clonidine and diclofenac

clonidine has been researched along with diclofenac in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's1 (3.85)18.2507
2000's12 (46.15)29.6817
2010's11 (42.31)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H1
Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M; Takao, Y1
Miranda, HF; Pinardi, G; Sierralta, F1
Foster, KA; Roberts, MS; Weiss, M1
Kimura, S; Kitamura, K; Ohashi, A; Shimamura, K; Toba, M1
Ambade, R; Bartakke, G; Chandanwale, AS; Chandurkar, N; Gupta, A; Pareek, A1
Homma, M; Kohda, Y; Matsumoto, S; Momo, K; Sasaki, T1
Anctil, JL; Champagne, S; Des Marchais, B; Goyette, A; Lajoie, C1
Bremer, N; Dizdarevic, A1
Belal, F; Derayea, S; Hammad, MA; Omar, MA; Saleh, SF; Zayed, S1
Bergo, C; Halvorsen, H; Krohn, J; Thrane, AS; Thrane, VR1

Reviews

1 review(s) available for clonidine and diclofenac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

5 trial(s) available for clonidine and diclofenac

ArticleYear
Oral clonidine premedication reduces vomiting in children after strabismus surgery.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:11

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Child, Preschool; Clonidine; Diazepam; Diclofenac; Double-Blind Method; Female; Humans; Incidence; Length of Stay; Male; Midazolam; Neuromuscular Nondepolarizing Agents; Pain, Postoperative; Placebos; Postoperative Complications; Preanesthetic Medication; Premedication; Prospective Studies; Strabismus; Vecuronium Bromide; Vomiting

1995
Diclofenac and flurbiprofen with or without clonidine for postoperative analgesia in children undergoing elective ophthalmological surgery.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:6

    Topics: Administration, Oral; Administration, Rectal; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Clonidine; Diclofenac; Drug Therapy, Combination; Elective Surgical Procedures; Flurbiprofen; Humans; Injections, Intravenous; Ophthalmologic Surgical Procedures; Pain Measurement; Pain, Postoperative

2000
Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2009, Volume: 18, Issue:12

    Topics: Activities of Daily Living; Acute Disease; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Diclofenac; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Therapy; Drug Therapy, Combination; Female; Humans; Low Back Pain; Male; Middle Aged; Mobility Limitation; Movement; Outcome Assessment, Health Care; Pain Measurement; Pain Threshold; Patient Satisfaction; Placebo Effect; Range of Motion, Articular; Treatment Outcome; Young Adult

2009
Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty.
    Journal francais d'ophtalmologie, 2015, Volume: 38, Issue:7

    Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Combined Modality Therapy; Diclofenac; Double-Blind Method; Eye Pain; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser Therapy; Male; Middle Aged; Models, Immunological; Pain, Postoperative; Placebos; Postoperative Complications; Prednisolone; Prospective Studies; Surveys and Questionnaires; Trabeculectomy; Treatment Outcome; Uveitis, Anterior

2015
Effect of Apraclonidine and Diclofenac on Early Changes in Intraocular Pressure After Selective Laser Trabeculoplasty.
    Journal of glaucoma, 2020, Volume: 29, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Diclofenac; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser Therapy; Lasers, Semiconductor; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Tonometry, Ocular; Trabeculectomy

2020

Other Studies

20 other study(ies) available for clonidine and diclofenac

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs

2013
An isobolographic analysis of the adrenergic modulation of diclofenac antinociception.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:2

    Topics: Adrenergic Agents; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Mice; Phenylephrine; Prazosin; Yohimbine

2001
Distribution kinetics of solutes in the isolated in-situ perfused rat head using the multiple indicator dilution technique and a physiological two-barrier model.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Brain; Clonidine; Creatine Kinase; Diclofenac; Female; L-Lactate Dehydrogenase; Metabolic Clearance Rate; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Salicylates; Structure-Activity Relationship

2002
Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2006, Volume: 42, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diclofenac; Endothelium, Vascular; Humans; Hypertension, Portal; In Vitro Techniques; Isometric Contraction; Liver Cirrhosis; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Portal Vein; Rats; Rats, Wistar

2006
[Clinical survey of tizanidine-induced adverse effects--impact of concomitant drugs providing cytochrome P450 1A2 modification--].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2013, Volume: 133, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Carbamazepine; Clonidine; Cytochrome P-450 CYP1A2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Retrospective Studies; Time Factors

2013
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome.
    Pain medicine (Malden, Mass.), 2017, 06-01, Volume: 18, Issue:6

    Topics: Adult; Analgesics; Cervical Vertebrae; Clonidine; Complex Regional Pain Syndromes; Diclofenac; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; Humans; Lamotrigine; Male; Oxycodone; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Spinal Cord Stimulation

2017
Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography.
    Journal of chromatographic science, 2018, Mar-01, Volume: 56, Issue:3

    Topics: Acetaminophen; Chromatography, Liquid; Clonidine; Diclofenac; Humans; Limit of Detection; Linear Models; Micelles; Reproducibility of Results; Sulfonamides; Tablets

2018