clonidine and clozapine

clonidine has been researched along with clozapine in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (25.64)	18.7374
1990's	8 (20.51)	18.2507
2000's	15 (38.46)	29.6817
2010's	6 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Batink, H; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Campbell, WB; Harper, DC; Keeton, TK; Pettinger, WA	1
Grabowski, J	1
Fitten, LJ; Lloyd, RL; Menon, MK	1
Ackenheil, M; Albus, M; Botschev, C; Müller-Spahn, F; Naber, D; Welter, D	1
Sanger, DJ	1
Fitten, J; Gordon, LI; Menon, MK	1
Górka, Z; Rawłów, A	1
Borsini, F; Nowakowska, E; Samanin, R	1
De Feo, G; Lisciani, R; Pavan, L; Samarelli, M; Valeri, P	1
Fink, H; Morgenstern, R; Oelssner, W	1
Corrigan, FM; MacDonald, S; Reynolds, GP	1
Campbell, M; Cueva, JE	1
Ahlenius, S; Karlsson, T; Salmi, P	1
Arkhapchev, IuP; Gol'dfarb, IuS; Il'iashenko, KK; Luzhnikov, EA; Matkevich, VA; Savina, AS; Sukhodolova, GN	1
Ballard, TM; McAllister, KH	1
Grottick, AJ; Herberg, LJ; Montgomery, AM	1
Arca, A; Casu, MA; Devoto, P; Flore, G; Gessa, GL; Pani, L; Pira, L; Vacca, G	1
Bartsch, C; Risse, M; Schütz, H; Weigand, N; Weiler, G	1
Praharaj, SK; Roy, D; Singh, A; Verma, P	1
Hainz, N; Kovačević, B; Meier, C; Rzagalinski, I; Tschernig, T; Volmer, DA	1

Reviews

2 review(s) available for clonidine and clozapine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II. Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:10 Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Clonidine; Clozapine; Depressive Disorder; Dose-Response Relationship, Drug; Feeding and Eating Disorders; Fluoxetine; Humans; Imipramine; Lithium; Mutism; Obsessive-Compulsive Disorder; Phenobarbital; Phenytoin; Phobic Disorders; Schizophrenia; Sleep Wake Disorders; Tranquilizing Agents	1995

Article

Year

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Drug discovery today, 2016, Volume: 21, Issue:4

Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.

Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:10

Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Clonidine; Clozapine; Depressive Disorder; Dose-Response Relationship, Drug; Feeding and Eating Disorders; Fluoxetine; Humans; Imipramine; Lithium; Mutism; Obsessive-Compulsive Disorder; Phenobarbital; Phenytoin; Phobic Disorders; Schizophrenia; Sleep Wake Disorders; Tranquilizing Agents

1995

Trials

1 trial(s) available for clonidine and clozapine

Article	Year
Is clonidine useful for treatment of clozapine-induced sialorrhea? Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:4 Topics: Adrenergic alpha-Agonists; Adult; Antipsychotic Agents; Clonidine; Clozapine; Female; Humans; Male; Middle Aged; Schizophrenia; Sialorrhea	2005

Other Studies

36 other study(ies) available for clonidine and clozapine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. Journal of medicinal chemistry, 1984, Volume: 27, Issue:4 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cell Membrane; Clonidine; Kinetics; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vasoconstriction	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Evidence for a renal alpha-adrenergic receptor inhibiting renin release. Circulation research, 1976, Volume: 38, Issue:5 Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Chlorisondamine; Clonidine; Clozapine; Hyponatremia; Juxtaglomerular Apparatus; Male; Methoxamine; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Renin; Sympathetic Nervous System	1976
Clonidine treatment of clozapine-induced hypersalivation. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:1 Topics: Adult; Clonidine; Clozapine; Female; Humans; Male; Middle Aged; Sialorrhea	1992
Antagonism of the hypothermic effect of clozapine in mice by centrally-active alpha 2-adrenergic antagonists and alpha 1-adrenergic agonists. Psychopharmacology, 1990, Volume: 101, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Clonidine; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Male; Mice	1990
Neuroendocrine effects of clonidine in chronic schizophrenic patients under long-term neuroleptic therapy and after drug withdrawal: relations to psychopathology. Psychopharmacology, 1986, Volume: 88, Issue:2 Topics: Adult; Antipsychotic Agents; Clonidine; Clozapine; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Norepinephrine; Receptors, Adrenergic, alpha; Schizophrenia; Schizophrenic Psychology	1986
Response decrement patterns after neuroleptic and non-neuroleptic drugs. Psychopharmacology, 1986, Volume: 89, Issue:1 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Chlordiazepoxide; Clonidine; Clozapine; Conditioning, Operant; Electroshock; Food; Male; Methocarbamol; Morphine; Rats; Rats, Inbred Strains	1986
Interaction between clozapine and a lipophilic alpha 1-adrenergic agonist. Life sciences, 1988, Volume: 43, Issue:22 Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Clonidine; Clozapine; Dextroamphetamine; Dibenzazepines; Drug Interactions; Drug Tolerance; Male; Methoxamine; Mice; Motor Activity; Prazosin	1988
Involvement of postsynaptic alpha 1- and alpha 2-adrenoceptors in the flexor reflex activity in the spinal rats. Journal of neural transmission, 1986, Volume: 66, Issue:2 Topics: Animals; Clonidine; Clozapine; Decerebrate State; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex; Spinal Cord; Yohimbine	1986
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs. Life sciences, 1984, Mar-19, Volume: 34, Issue:12 Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride	1984
Possible dopaminergic involvement in biting compulsion induced by large doses of clonidine. Pharmacological research communications, 1983, Volume: 15, Issue:6 Topics: Aggression; Amphetamine; Animals; Clonidine; Clozapine; Dopamine; Drug Interactions; Female; Haloperidol; Humans; Male; Mice; Phenoxybenzamine; Scopolamine	1983
Clozapine--a serotonin antagonist? Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:4 Topics: Animals; Apomorphine; Clonidine; Clozapine; Dibenzazepines; Drug Interactions; Haloperidol; Lysergic Acid Diethylamide; Male; Microinjections; Motor Activity; Nucleus Accumbens; Phentolamine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin Antagonists	1984
Clozapine-induced hypersalivation and the alpha 2 adrenoceptor. The British journal of psychiatry : the journal of mental science, 1995, Volume: 167, Issue:3 Topics: Antipsychotic Agents; Chronic Disease; Clonidine; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Middle Aged; Receptors, Adrenergic, alpha-2; Schizophrenia; Sialorrhea	1995
Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat. European journal of pharmacology, 1994, Feb-21, Volume: 253, Issue:1-2 Topics: Amphetamines; Animals; Benzazepines; Body Temperature; Body Temperature Regulation; Chromans; Clonidine; Clozapine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Ergolines; Hypothermia; Injections, Subcutaneous; Male; Oxotremorine; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Salicylamides; Serotonin Antagonists	1994
[Clinical manifestation, diagnosis and treatment of rare forms of acute drug poisoning (lecture)]. Terapevticheskii arkhiv, 1998, Volume: 70, Issue:10 Topics: Adolescent; Adult; Antihypertensive Agents; Antipsychotic Agents; Calcium Chloride; Clonidine; Clozapine; Diagnosis, Differential; Drug Combinations; Humans; Hyperbaric Oxygenation; Poisoning; Sorption Detoxification; Vitamin D	1998
Acutely administered clozapine does not modify naloxone-induced withdrawal jumping in morphine-dependent mice. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2 Topics: Analgesics; Animals; Antipsychotic Agents; Clonidine; Clozapine; Haloperidol; Male; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome	1999
Rapid recovery of self-stimulation responding from depression by clozapine is prevented by the alpha 2-adrenoceptor agonist, clonidine. Behavioural pharmacology, 1999, Volume: 10, Issue:5 Topics: Adrenergic alpha-Agonists; Animals; Antipsychotic Agents; Clonidine; Clozapine; Depression; Dose-Response Relationship, Drug; Electric Stimulation; Idazoxan; Male; Rats; Risperidone; Self Stimulation; Tegmentum Mesencephali	1999
Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic. Psychopharmacology, 2003, Volume: 167, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Antipsychotic Agents; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Clozapine; Dopamine; Dopamine Agonists; Extracellular Space; Immunohistochemistry; Male; Microdialysis; Neurons; Norepinephrine; Occipital Lobe; Prefrontal Cortex; Quinpirole; Rats; Rats, Sprague-Dawley	2003
Munchausen syndrome by proxy (MSBP): an extreme form of child abuse with a special forensic challenge. Forensic science international, 2003, Nov-26, Volume: 137, Issue:2-3 Topics: Antipsychotic Agents; Child, Preschool; Clonidine; Clozapine; Female; Forensic Medicine; Hair; Hospitalization; Humans; Infant; Male; Munchausen Syndrome by Proxy; Siblings; Sympatholytics	2003
Toward Higher Sensitivity in Quantitative MALDI Imaging Mass Spectrometry of CNS Drugs Using a Nonpolar Matrix. Analytical chemistry, 2018, 11-06, Volume: 90, Issue:21 Topics: Animals; Brain Chemistry; Calibration; Central Nervous System Agents; Clonidine; Clozapine; Hydrophobic and Hydrophilic Interactions; Imipramine; Ketamine; Limit of Detection; Mice, Inbred C57BL; Nitriles; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xylazine	2018