clonidine and caffeine

clonidine has been researched along with caffeine in 97 studies

Research

Studies (97)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (23.71)	18.7374
1990's	7 (7.22)	18.2507
2000's	28 (28.87)	29.6817
2010's	37 (38.14)	24.3611
2020's	2 (2.06)	2.80

Authors

Authors	Studies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Faassen, F; Spanings, H; Vogel, G; Vromans, H	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Akamatsu, M	1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM	1
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM	1
Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G	1
Jiang, N; Kong, LY; Lan, JS; Li, ZR; Wang, KD; Wang, X; Xie, SS; Yu, W	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G	1
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y	1
Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y	1
Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X	1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L	1
Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L	1
Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L	2
Dong, SN; Gong, Q; Li, J; Li, XK; Liu, WW; Mao, F; Tang, Y; Wang, H; Wang, TD; Xu, YX; Zhang, HY; Zhu, J	1
Huang, Q; Jiang, N; Li, Q; Liang, N; Liu, J; Xie, SS	1
Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X	1
Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y	1
Gong, Q; Li, J; Li, X; Liu, W; Mao, F; Qiu, X; Wang, H; Wang, W; Xu, Y; Zhang, H; Zhang, J; Zhu, J	1
An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T	1
Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z	1
Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C	1
Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K	1
Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P	1
Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G	1
Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C	1
Chen, H; Ding, H; Gao, Y; Jiang, X; Liu, W; Liu, X; Tian, L; Xu, Z; Zhao, Q	1
Meyer, C	1
Fujiwara, M; Oishi, R; Razzak, A; Ueki, S	1
Fozard, JR	1
Fanchamps, A	1
Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G	1
Waldeck, B	5
Chase, TN; Shoulson, I	1
Hirose, H; Itoh, K; Kido, K; Koyama, K; Maruyama, H; Saruta, T	1
Black, B; Boulenger, JP; Geraci, M; Gurguis, G; Post, RM; Roscow, DB; Rubinow, DR; Tancer, ME; Uhde, TW; Vittone, B	1
Biguad, M; Julou-Schaeffer, G; Parratt, JR; Stoclet, JC	1
Elphick, M; Godfrey, PP; Powell, T; Taghavi, Z	1
Holtzman, SG	1
Baldwin, HA; File, SE	1
Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Mantzouridis, T; Xiang, JZ	1
Hara, T; Kajimura, N; Kaneyuki, H; Mashimoto, S; Mizuki, Y; Ushijima, I; Yamada, M	1
Fujiwara, Y; Kazahaya, Y; Otsuki, S; Sandyk, R; Takeda, T	1
Breier, A; Charney, DS; Heninger, GR	1
Mattila, M; Mattila, MJ; Seppala, T	1
Coffin, VL; Spealman, RD	1
Curatolo, PW; Goldberg, MR; Robertson, D; Tung, CS	1
Boulenger, JP; Jimerson, DC; Post, RM; Roy-Byrne, PP; Siever, LJ; Uhde, TW; Vittone, BJ	1
Mueller, K; Nyhan, WL	1
Gould, DJ; Hill, CE	1
Calatayud, S; D'Ocon, MP; Noguera, MA	1
Feikema, WJ	1
Jinnah, HA; Kasim, S	1
Brice, C; Nash, J; Nutt, DJ; Rich, N; Smith, A	1
Backman, JT; Granfors, MT; Neuvonen, M; Neuvonen, PJ	1
Backman, JT; Granfors, MT; Laitila, J; Neuvonen, PJ	1
Backman, JT; Granfors, MT; Neuvonen, PJ	1
Backman, JT; Karjalainen, MJ; Laitila, J; Neuvonen, M; Neuvonen, PJ	1
Backman, JT; Neuvonen, PJ; Schröder, MT	1
Backman, JT; Karjalainen, MJ; Neuvonen, PJ	1
Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J	1
Chiba, K; Haraya, K; Kato, M; Sugiyama, Y	1
Mohs, AJ; Peace, MR; Poklis, A; Poklis, JL; Wolf, CE	1
Barco, S; Bruschettini, M; Cangemi, G; Ley, D; Romantsik, O; Tripodi, G	1

Reviews

6 review(s) available for clonidine and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The animal pharmacology of drugs used in the treatment of migraine. The Journal of pharmacy and pharmacology, 1975, Volume: 27, Issue:5 Topics: Acetaminophen; Adrenergic alpha-Antagonists; Analgesics; Animals; Aspirin; Caffeine; Clonidine; Cyproheptadine; Dihydroergotamine; Ergotamine; Humans; Methysergide; Migraine Disorders; Monoamine Oxidase Inhibitors; Muscle, Smooth; Pizotyline; Serotonin Antagonists; Sympathetic Nervous System; Synaptic Transmission; Tryptamines; Vagus Nerve; Vasoconstrictor Agents; Vasodilator Agents	1975
[Classification, pathogenesis and drug therapy of migraine and related forms of headache]. Die Medizinische Welt, 1975, Aug-29, Volume: 6, Issue:35 Topics: Adrenergic beta-Antagonists; Animals; Caffeine; Clonidine; Dihydroergotamine; Drug Synergism; Epinephrine; Ergotamine; Headache; Histamine; Humans; Methysergide; Mice; Migraine Disorders; Norepinephrine; Pizotyline; Serotonin	1975
Evidence for hypothalamo-growth hormone dysfunction in panic disorder: profile of growth hormone (GH) responses to clonidine, yohimbine, caffeine, glucose, GRF and TRH in panic disorder patients versus healthy volunteers. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 6, Issue:2 Topics: Caffeine; Clonidine; Glucose; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Hypothalamus; Panic Disorder; Thyrotropin-Releasing Hormone; Yohimbine	1992
The diagnostic validity of anxiety disorders and their relationship to depressive illness. The American journal of psychiatry, 1985, Volume: 142, Issue:7 Topics: Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Clonidine; Cross-Sectional Studies; Depressive Disorder; Epinephrine; Follow-Up Studies; Humans; Lactates; Norepinephrine; Panic; Propranolol; Receptors, GABA-A; Research Design	1985
[Headache and chronic sleep deprivation: an often missed relationship in children and also in adults]. Nederlands tijdschrift voor geneeskunde, 1999, Sep-18, Volume: 143, Issue:38 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Caffeine; Central Nervous System Stimulants; Child; Child Behavior; Chronic Disease; Clonidine; Diagnosis, Differential; Female; Habits; Headache; Humans; Male; Medical History Taking; Sleep Deprivation; Sleep Initiation and Maintenance Disorders	1999

Trials

9 trial(s) available for clonidine and caffeine

Article	Year
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1975, Sep-19, Volume: 117, Issue:38 Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, Combination; Ergotamine; Headache; Histamine; Humans; Indomethacin; Metergoline; Methysergide; Migraine Disorders; Pizotyline; Prochlorperazine; Reserpine; Retrospective Studies; Urea	1975
Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam. International clinical psychopharmacology, 1988, Volume: 3, Issue:3 Topics: Adult; Anxiety; Arousal; Caffeine; Clonidine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Female; Growth Hormone; Humans; Hydrocortisone; Male; Panic; Prolactin; Yohimbine	1988
Caffeine and central noradrenaline: effects on mood, cognitive performance, eye movements and cardiovascular function. Journal of psychopharmacology (Oxford, England), 2003, Volume: 17, Issue:3 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Affect; Caffeine; Cardiovascular System; Central Nervous System Stimulants; Clonidine; Cognition; Humans; Male; Memory; Norepinephrine; Saccades	2003
Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:6 Topics: Adult; Anti-Infective Agents; Area Under Curve; Blood Pressure; Caffeine; Chromatography, High Pressure Liquid; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Half-Life; Heart Rate; Humans; Muscle Relaxants, Central; Phosphodiesterase Inhibitors	2004
Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2. Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:4 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Area Under Curve; Caffeine; Clonidine; Contraceptives, Oral, Combined; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Ethinyl Estradiol; Female; Half-Life; Humans; Norpregnenes; Theophylline	2005
Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine. European journal of clinical pharmacology, 2006, Volume: 62, Issue:6 Topics: Adult; Anti-Bacterial Agents; Blood Pressure; Caffeine; Clonidine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Drug Interactions; Enzyme Induction; Female; Heart Rate; Humans; Male; Rifampin	2006
Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. British journal of clinical pharmacology, 2006, Volume: 62, Issue:3 Topics: Adult; Caffeine; Central Nervous System Stimulants; Clonidine; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP1A2 Inhibitors; Double-Blind Method; Drug Interactions; Humans; Lactones; Male; Sulfones	2006
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine. European journal of clinical pharmacology, 2008, Volume: 64, Issue:1 Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Drug Interactions; Female; Half-Life; Humans; Male; Sex Factors; Sleep Stages; Smoking; Theophylline	2008
Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo. European journal of clinical pharmacology, 2008, Volume: 64, Issue:5 Topics: Adult; Area Under Curve; Caffeine; Celecoxib; Clonidine; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Female; Half-Life; Humans; In Vitro Techniques; Male; Microsomes, Liver; Pyrazoles; Sulfonamides	2008

Other Studies

82 other study(ies) available for clonidine and caffeine

Article	Year
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry, 2011, Volume: 46, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine	2011
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding	2012
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats	2015
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European journal of medicinal chemistry, 2015, May-05, Volume: 95 Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Coumarins; Drug Design; Erythrocytes; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Piperazines; Tacrine	2015
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 05-15, Volume: 24, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine	2016
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured	2016
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship	2017
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2017, Jan-27, Volume: 126 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats	2017
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine	2017
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry letters, 2017, 02-15, Volume: 27, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary	2017
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry, 2017, 03-15, Volume: 25, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones	2017
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques	2017
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats	2017
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2017, 06-15, Volume: 25, Issue:12 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine	2017
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22 Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship	2017
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship	2017
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2018, Jan-01, Volume: 143 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Discovery; Humans; Imidazoles; Mice; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Propylamines; Pyrimidines; Rats; Scopolamine; Structure-Activity Relationship; Thiourea	2018
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2018, Feb-25, Volume: 146 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Line, Tumor; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Drug Design; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Aggregates; Range of Motion, Articular; Structure-Activity Relationship; Thiocarbamates	2018
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. Bioorganic & medicinal chemistry, 2018, 03-01, Volume: 26, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship	2018
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles	2018
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12 Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Depression; Drug Design; Ligands; Mice; Permeability; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Tacrine; Vilazodone Hydrochloride	2018
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold. Bioorganic & medicinal chemistry letters, 2018, 06-15, Volume: 28, Issue:11 Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship	2018
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2018, 12-15, Volume: 26, Issue:23-24 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship	2018
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities. Bioorganic & medicinal chemistry, 2019, 03-15, Volume: 27, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine	2019
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Sep-15, Volume: 178 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship	2019
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates	2019
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship	2019
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry, 2019, Dec-01, Volume: 183 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship	2019
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2021, Oct-15, Volume: 222 Topics: Alzheimer Disease; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Dyrk Kinases; Glycogen Synthase Kinase 3 beta; Harmine; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship	2021
[Treatment of migraine (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1975, Feb-25, Volume: 64, Issue:8 Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents; Caffeine; Child; Clonidine; Drug Therapy, Combination; Ergotamine; Humans; Migraine Disorders; Serotonin Antagonists	1975
Possible involvement of a central noradrenergic system in automutilation induced by clonidine in mice. Japanese journal of pharmacology, 1977, Volume: 27, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Caffeine; Catecholamines; Chlorpromazine; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Humans; Levodopa; Male; Methamphetamine; Methyltyrosines; Mice; Phenoxybenzamine; Phentolamine; Reserpine; Self Mutilation; Sympathetic Nervous System; Theophylline	1977
Drugs for migraine. The Medical letter on drugs and therapeutics, 1976, Jun-18, Volume: 18, Issue:13 Topics: Caffeine; Clonidine; Drug Synergism; Ergotamine; Heart Valve Diseases; Humans; Methysergide; Migraine Disorders; Mitral Valve Insufficiency; Propranolol; Pulmonary Fibrosis	1976
Effect of caffeine on locomotor activity and central catecholamine mechanisms: a study with special reference to drug interaction. Acta pharmacologica et toxicologica, 1975, Volume: 36, Issue:Suppl 4 Topics: Animals; Atropine; Barbiturates; Caffeine; Catecholamines; Clonidine; Dihydroxyphenylalanine; Drug Interactions; Drug Synergism; Ethanol; Female; Mice; Motor Activity; Reserpine; Time Factors	1975
Dopaminergic mechanisms in patients with extrapyramidal disease. Advances in neurology, 1975, Volume: 9 Topics: Animals; Biogenic Amines; Brain; Caffeine; Clonidine; Dopamine; Drug Evaluation; Drug Therapy, Combination; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Levodopa; Parasympatholytics; Parkinson Disease; Piperazines; Piribedil; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Drug; Stimulation, Chemical	1975
On the interaction between caffeine and barbiturates with respect to locomotor activity and brain catecholamines. Acta pharmacologica et toxicologica, 1975, Volume: 36, Issue:2 Topics: Animals; Brain; Caffeine; Clonidine; Dopamine; Drug Interactions; Female; Mice; Motor Activity; Norepinephrine; Pentobarbital; Phenobarbital; Piribedil; Reserpine	1975
Arachidonic acid metabolites and alpha 2-adrenoceptor-mediated glucagon secretion in rats. Diabetes research and clinical practice, 1992, Volume: 16, Issue:3 Topics: Animals; Arachidonic Acids; Aspirin; Caffeine; Clonidine; Glucose; In Vitro Techniques; Islets of Langerhans; Male; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha	1992
Endotoxin-induced impairment of vascular smooth muscle contractions elicited by different mechanisms. European journal of pharmacology, 1990, Nov-06, Volume: 190, Issue:1-2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Caffeine; Calcimycin; Calcium; Clonidine; Endothelium, Vascular; Endotoxins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum	1990
Chronic carbamazepine down-regulates adenosine A2 receptors: studies with the putative selective adenosine antagonists PD115,199 and PD116,948. Psychopharmacology, 1990, Volume: 100, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Brain Chemistry; Caffeine; Carbamazepine; Clonidine; Cyclic AMP; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenylisopropyladenosine; Purines; Receptors, Adrenergic; Sulfonamides; Theophylline; Xanthines	1990
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline	1986
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior	1989
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism? Journal of neurochemistry, 1989, Volume: 53, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Caffeine; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Fluorescent Dyes; Fura-2; Homeostasis; Idazoxan; Male; Naloxone; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Synaptosomes	1989
Effects of dilazep (Comelian) on the central purinergic system: inhibitory effects on clonidine-induced aggressive behavior. European journal of pharmacology, 1989, Feb-28, Volume: 161, Issue:2-3 Topics: Aggression; Animals; Azepines; Caffeine; Clonidine; Dilazep; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Phenylisopropyladenosine; Purines; Theophylline	1989
Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice. The International journal of neuroscience, 1988, Volume: 42, Issue:1-2 Topics: Adenosine; Aggression; Animals; Behavior, Animal; Caffeine; Carbamazepine; Clonidine; Haloperidol; Male; Mice; Prazosin; Receptors, Cell Surface; Yohimbine	1988
Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Blood Pressure; Caffeine; Cardiovascular System; Clonidine; Cocaine; Dextroamphetamine; Heart Rate; Isomerism; Macaca fascicularis; Male; Phenylisopropyladenosine	1987
Modification of the caffeine-induced locomotor stimulation by a cholinergic mechanism. Journal of neural transmission, 1974, Volume: 35, Issue:3 Topics: Animals; Antiparkinson Agents; Atropine; Benztropine; Caffeine; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Female; Locomotion; Mice; Mice, Inbred Strains; Physostigmine; Piperazines; Pyrimidines; Reserpine; Stimulation, Chemical; Time Factors	1974
Sensitization by caffeine of central catecholamine receptors. Journal of neural transmission, 1973, Volume: 34, Issue:1 Topics: Animals; Body Temperature; Caffeine; Clonidine; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Female; Hypothermia; Methyltyrosines; Mice; Motor Activity; Norepinephrine; Pimozide; Piperazines; Receptors, Drug; Reserpine; Stimulation, Chemical	1973
Ethanol and caffeine: a complex interaction with respect to locomotor activity and central catecholamines. Psychopharmacologia, 1974, Apr-23, Volume: 36, Issue:3 Topics: Analysis of Variance; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benzyl Compounds; Brain; Caffeine; Catecholamines; Chemoreceptor Cells; Clonidine; Dihydroxyphenylalanine; Dopamine; Drug Interactions; Ethanol; Female; Hydrazines; Locomotion; Mice; Norepinephrine; Piperazines; Pyrimidines; Receptors, Drug; Reserpine; Stimulation, Chemical; Tritium; Tyrosine	1974
Caffeine down-regulates beta adrenoreceptors in rat forebrain. Neuroscience letters, 1982, Jul-20, Volume: 31, Issue:1 Topics: alpha-Methyltyrosine; Animals; Binding, Competitive; Brain; Caffeine; Clonidine; Dihydroalprenolol; Dopamine; Female; Methyltyrosines; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Synaptic Transmission	1982
Fear and anxiety: relationship to noradrenergic function. Psychopathology, 1984, Volume: 17 Suppl 3 Topics: Animals; Anxiety; Caffeine; Clonidine; Dose-Response Relationship, Drug; Fear; Humans; Locus Coeruleus; Sympathetic Nervous System	1984
Clonidine potentiates drug induced self-injurious behavior in rats. Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:6 Topics: Amphetamine; Animals; Caffeine; Clonidine; Dose-Response Relationship, Drug; Drug Implants; Drug Synergism; Humans; Male; Motor Activity; Rats; Self Mutilation; Stereotyped Behavior	1983
Alpha 1B-receptors and intracellular calcium mediate sympathetic nerve induced constriction of rat irideal blood vessels. Journal of the autonomic nervous system, 1994, Dec-15, Volume: 50, Issue:2 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Caffeine; Calcium; Calcium Channel Blockers; Clonidine; Electric Stimulation; Female; In Vitro Techniques; Iris; Male; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Regional Blood Flow; Sympathetic Nervous System; Synapses	1994
Actions of alpha-adrenoceptor blocking agents on two types of intracellular calcium stores mobilized by noradrenaline in rat aorta. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 348, Issue:5 Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Caffeine; Calcium; Clonidine; Endothelium, Vascular; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Wistar	1993
Pharmacologic thresholds for self-injurious behavior in a genetic mouse model of Lesch-Nyhan disease. Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:3 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Caffeine; Calcium Channel Agonists; Central Nervous System Stimulants; Clonidine; Dystonia; Lesch-Nyhan Syndrome; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Movement Disorders; Pemoline; Piperazines; Self-Injurious Behavior	2002
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. Physical therapy, 2013, Volume: 93, Issue:3 Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; Fenclonine; Hyperalgesia; Male; Mice; Morphine; Pain, Postoperative; Receptor, Adenosine A1; Xanthines; Yohimbine	2013
Prediction of inter-individual variability on the pharmacokinetics of CYP1A2 substrates in non-smoking healthy volunteers. Drug metabolism and pharmacokinetics, 2016, Volume: 31, Issue:4 Topics: Area Under Curve; Caffeine; Clonidine; Cytochrome P-450 CYP1A2; Healthy Volunteers; Humans; Lidocaine; Monte Carlo Method; Phenacetin; Theophylline	2016
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS). Journal of analytical toxicology, 2016, Volume: 40, Issue:8 Topics: Amides; Analgesics; Anesthetics; Baclofen; Bupivacaine; Caffeine; Chromatography, High Pressure Liquid; Clonidine; Dexamethasone; Ephedrine; Fentanyl; Heparin; Hydromorphone; Ketamine; Mass Spectrometry; Methadone; Midazolam; Morphine; Oxytocin; Parenteral Nutrition Solutions; Phenylephrine; Ropivacaine; Succinylcholine	2016
A LC-MS/MS method for the quantification of caffeine, betamethasone, clonidine and furosemide in cerebrospinal fluid of preterm infants. Journal of pharmaceutical and biomedical analysis, 2020, Feb-05, Volume: 179 Topics: Betamethasone; Caffeine; Chromatography, Liquid; Clonidine; Female; Furosemide; Humans; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Male; Reproducibility of Results; Tandem Mass Spectrometry	2020