clonidine and amiloride

clonidine has been researched along with amiloride in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19905 (14.71)18.7374
1990's15 (44.12)18.2507
2000's10 (29.41)29.6817
2010's4 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Conn, C; Cordaro, F; Hargraves, TL; Ibrahim, P; Shimmon, R1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Segre, G; Tilser, I1
Chen, L; Rouch, AJ; Schafer, JA; Troutman, SL1
Elliott, WJ; Fumo, MT; Gramelspacher, GP; Gretler, DD; Murphy, MB1
Cragoe, EJ; Ganapathy, V; Kulanthaivel, P; Leibach, FH; Mahesh, VB1
Atlas, D; Coupry, I; Parini, A; Podevin, RA; Uzielli, I1
Giovannini, P; Girardier, L; Seydoux, J1
Devoe, LD; Ganapathy, ME; Ganapathy, V; Leibach, FH; Mahesh, VB1
Felton, K; Hui, TP; Krakoff, LR; Yeager, K1
Bauer, P; Dorcsi, M; Hitzenberger, G; Korn, A; Wohlzogen, FX1
Padan, E; Pinner, E; Schuldiner, S1
Orlowski, J; Shull, GE; Yu, FH1
Ganapathy, V; Reinach, P; Torres-Zamorano, V1
Hamilton, JR; MacLeod, RJ1
Angelini, R; Ascenzi, P; Ercolini, L; Federico, R; Mattevi, A; Venturini, G1
Casavola, V; Di Sole, F; Guerra, L; Perlino, E; Reshkin, SJ; Ronco, PM; Valenti, G1
Brunette, MG; Claveau, D; Leclerc, M; Pellerin, I1
Angelini, R; Ascenzi, P; Ercolini, L; Federico, R; Rea, G; Venturini, G1
Danbury, TC; Hudson, AL; Kestin, SC; Ruban, B; Waterman-Pearson, AE1
Chow, CW1
Pihlavisto, M; Scheinin, M1
Parker, MS; Parker, SL1
Alli, HA; Angle, JM; Black, ED; Donowitz, M; Madara, JL; Tse, CM; Turner, JR; Uchwat, FA; Ward, J1
Petzel, DH1
Angelini, R; Ascenzi, P; Binda, C; Botta, M; Federico, R; Leone, L; Venturini, G1
Raasmaja, A; Römer, L; Savola, JM; Wurster, S1
Adir, Y; Azzam, ZS; Comellas, A; Crespo, A; Dada, LA; Krivoy, N; Lecuona, E; Ridge, KM; Rutschman, DH; Sznajder, JI1
Bai, X; Chen, D; Dohi, S; Huang, W; Ouyang, H; Zeng, W1

Reviews

2 review(s) available for clonidine and amiloride

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1999, Volume: 22, Issue:5

    Topics: Adenosine Triphosphate; Amiloride; Animals; Cimetidine; Clonidine; Epithelial Cells; Guanidines; Ion Transport; Kidney; Phosphorylation; Protein Isoforms; Sodium-Hydrogen Exchangers; Sulfones

1999

Trials

2 trial(s) available for clonidine and amiloride

ArticleYear
Influence of diuretic therapy on the clonidine suppression test.
    Journal of clinical pharmacology, 1991, Volume: 31, Issue:5

    Topics: Adult; Amiloride; Clonidine; Double-Blind Method; Drug Combinations; Humans; Hydrochlorothiazide; Hypertension; Male; Norepinephrine; Premedication

1991
[Controlled randomized double-blind study for the comparison of the treatment of patients with essential hypertension with homeopathic and with pharmacologically effective drugs].
    Wiener klinische Wochenschrift, 1982, Dec-24, Volume: 94, Issue:24

    Topics: Amiloride; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Combinations; Female; Homeopathy; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pindolol; Pulse; Random Allocation

1982

Other Studies

30 other study(ies) available for clonidine and amiloride

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines.
    Bioorganic & medicinal chemistry letters, 2001, Oct-08, Volume: 11, Issue:19

    Topics: Amine Oxidase (Copper-Containing); Enzyme Inhibitors; Molecular Conformation; Pargyline; Structure-Activity Relationship

2001
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
The effect of clonidine, triamterene, and amiloride on pharmacokinetics and cardiotoxicity of ouabain in rabbits.
    Pharmacological research communications, 1978, Volume: 10, Issue:8

    Topics: Amiloride; Animals; Arrhythmias, Cardiac; Clonidine; Electrocardiography; Heart Rate; Kinetics; Male; Myocardium; Ouabain; Pyrazines; Rabbits; Time Factors; Triamterene

1978
Na+ transport in isolated rat CCD: effects of bradykinin, ANP, clonidine, and hydrochlorothiazide.
    The American journal of physiology, 1991, Volume: 260, Issue:1 Pt 2

    Topics: Amiloride; Animals; Atrial Natriuretic Factor; Biological Transport; Bradykinin; Clonidine; Electric Conductivity; Hydrochlorothiazide; Kidney Tubules, Collecting; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Sodium; Sodium Channels

1991
The Na(+)-H+ exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane.
    The Journal of biological chemistry, 1990, Jan-25, Volume: 265, Issue:3

    Topics: Amiloride; Animals; Carrier Proteins; Cell Membrane; Cell-Free System; Cimetidine; Clonidine; Harmaline; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Cortex; Microvilli; Placenta; Rabbits; Sodium; Sodium-Hydrogen Exchangers

1990
Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Amiloride; Animals; Binding Sites; Clonidine; Dioxanes; Dioxins; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Kidney Tubules, Proximal; Magnesium; Male; Potassium; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Yohimbine

1990
Evidence for a modulating effect of Na+/H+ exchange on the metabolic response of rat brown adipose tissue.
    Pflugers Archiv : European journal of physiology, 1988, Volume: 411, Issue:3

    Topics: Adipose Tissue, Brown; Amiloride; Animals; Clonidine; Hydrogen-Ion Concentration; Ion Exchange; Isoproterenol; Male; Membrane Potentials; Oxygen Consumption; Protons; Rats; Rats, Inbred Strains; Sodium

1988
Interaction of clonidine with human placental Na+ -H+ exchanger.
    Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22

    Topics: Amiloride; Carrier Proteins; Cimetidine; Clonidine; Female; Humans; In Vitro Techniques; Kinetics; Microvilli; Placenta; Pregnancy; Sodium; Sodium-Hydrogen Exchangers

1986
Diuretic treatment alters clonidine suppression of plasma norepinephrine.
    Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:4

    Topics: Administration, Oral; Amiloride; Blood Glucose; Blood Pressure; Body Weight; Clonidine; Drug Interactions; Epinephrine; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Norepinephrine; Potassium; Radioimmunoassay; Renin; Sodium

1986
Amiloride and harmaline are potent inhibitors of NhaB, a Na+/H+ antiporter from Escherichia coli.
    FEBS letters, 1995, May-22, Volume: 365, Issue:1

    Topics: Amiloride; Bacterial Proteins; Biological Transport; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Escherichia coli; Harmaline; Proteolipids; Sodium; Sodium-Hydrogen Exchangers

1995
Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.
    The Journal of biological chemistry, 1993, Dec-05, Volume: 268, Issue:34

    Topics: Amiloride; Animals; Biological Transport, Active; Carrier Proteins; CHO Cells; Cimetidine; Clone Cells; Clonidine; Cricetinae; Harmaline; Hydrogen-Ion Concentration; Kinetics; Rats; Sodium; Sodium-Hydrogen Exchangers

1993
Characterization and subtype identification of the Na(+)-H+ exchanger in bovine corneal epithelium.
    Current eye research, 1993, Volume: 12, Issue:1

    Topics: Amiloride; Animals; Binding, Competitive; Carrier Proteins; Cattle; Cell Membrane; Cimetidine; Clonidine; Cornea; Epithelium; Hydrogen-Ion Concentration; Sodium; Sodium-Hydrogen Exchangers; Temperature

1993
Activation of Na+/H+ exchange is required for regulatory volume decrease after modest "physiological" volume increases in jejunal villus epithelial cells.
    The Journal of biological chemistry, 1996, Sep-20, Volume: 271, Issue:38

    Topics: Alkalies; Amiloride; Ammonium Chloride; Animals; Biological Transport; Cell Size; Cimetidine; Clonidine; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Guinea Pigs; Hydrogen-Ion Concentration; Jejunum; Male; Protons; Sodium

1996
Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate.
    Biochemical and biophysical research communications, 1997, Nov-07, Volume: 240, Issue:1

    Topics: Agmatine; Amiloride; Amine Oxidase (Copper-Containing); Animals; Binding, Competitive; Catalysis; Clonidine; Gabexate; Kidney; Kinetics; Oxidation-Reduction; Putrescine; Swine

1997
Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells.
    Kidney international, 1998, Volume: 53, Issue:5

    Topics: Amiloride; Animals; Base Sequence; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Clonidine; DNA Primers; Guanidines; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney Tubules, Collecting; Kinetics; Polymerase Chain Reaction; Protein Kinases; Rabbits; Sodium-Hydrogen Exchangers; Sulfones

1998
Characterization of the Na+/H+ exchanger in the luminal membrane of the distal nephron.
    The Journal of membrane biology, 1998, Oct-01, Volume: 165, Issue:3

    Topics: Amiloride; Animals; Biological Transport; Bucladesine; Cell Membrane; Cimetidine; Clonidine; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Nephrons; Rabbits; Rats; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate

1998
Competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenylindole and gabexate mesylate: a comparative study.
    Journal of enzyme inhibition, 1998, Volume: 13, Issue:6

    Topics: Amiloride; Amine Oxidase (Copper-Containing); Benzamidines; Binding, Competitive; Clonidine; Enzyme Inhibitors; Gabexate; Indoles; Kinetics; Plant Proteins; Structure-Activity Relationship

1998
Imidazoline (I2) binding sites in chicken brain.
    Annals of the New York Academy of Sciences, 1999, Jun-21, Volume: 881

    Topics: Agmatine; Amiloride; Animals; Benzofurans; Binding Sites; Binding, Competitive; Brain; Chickens; Clonidine; Idazoxan; Imidazoles; Imidazoline Receptors; Kinetics; Receptors, Drug; Tritium

1999
Functional assessment of recombinant human alpha(2)-adrenoceptor subtypes with cytosensor microphysiometry.
    European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Amiloride; Animals; Binding, Competitive; Biosensing Techniques; Brimonidine Tartrate; CHO Cells; Cholera Toxin; Clonidine; Cricetinae; Dexmedetomidine; Egtazic Acid; Humans; Hydrogen-Ion Concentration; Norepinephrine; Pertussis Toxin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Signal Transduction; Virulence Factors, Bordetella

1999
Ligand association with the rabbit kidney and brain Y1, Y2 and Y5-like neuropeptide Y (NPY) receptors shows large subtype-related differences in sensitivity to chaotropic and alkylating agents.
    Regulatory peptides, 2000, Feb-08, Volume: 87, Issue:1-3

    Topics: Alkylating Agents; Amiloride; Amino Acid Sequence; Animals; Brain; CHO Cells; Clonidine; Cricetinae; Cystamine; Ethylmaleimide; Gastrointestinal Hormones; GTP-Binding Protein alpha Subunits, Gs; Guinea Pigs; Humans; Hypothalamus; Kidney; Ligands; Mesylates; Molecular Sequence Data; Peptide Fragments; Peptide YY; Rabbits; Radioligand Assay; Receptors, Neuropeptide Y; Sodium Cholate; Sulfhydryl Compounds; Urea

2000
Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3.
    American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6

    Topics: Acids; Alkalies; Amiloride; Animals; Anti-Ulcer Agents; Antihypertensive Agents; Biological Transport; Caco-2 Cells; Cimetidine; Clonidine; Cytoplasm; Diuretics; Electric Impedance; Electrophysiology; Epithelial Cells; Glucose; Guanidines; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa; Methacrylates; Microvilli; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tight Junctions

2000
Na(+)/H(+) exchange in mosquito Malpighian tubules.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Aedes; Amiloride; Ammonium Chloride; Animals; Cell Membrane; Clonidine; Harmaline; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Malpighian Tubules; Sodium; Sodium-Hydrogen Exchangers

2000
Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.
    Journal of enzyme inhibition, 2001, Volume: 16, Issue:2

    Topics: Agmatine; Amiloride; Amine Oxidase (Copper-Containing); Animals; Benzamidines; Cattle; Clonidine; Enzyme Inhibitors; Gabexate; Guanidines; Indoles; Kidney; Kinetics; Liver; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidoreductases Acting on CH-NH Group Donors; Pisum sativum; Polyamine Oxidase; Structure-Activity Relationship; Swine; Trypsin; Trypsin Inhibitors; Zea mays

2001
Identification and characterization of the imidazoline I2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors.
    Archives of physiology and biochemistry, 2003, Volume: 111, Issue:2

    Topics: Adipose Tissue, Brown; Amiloride; Animals; Binding Sites; Binding, Competitive; Cell Line, Tumor; Clonidine; Culture Techniques; Dose-Response Relationship, Drug; Guanabenz; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Liver; Mammary Neoplasms, Animal; Mice; Protein Binding; Rats; Receptors, Drug; Species Specificity; Yohimbine

2003
Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
    American journal of respiratory and critical care medicine, 2004, Oct-01, Volume: 170, Issue:7

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amiloride; Animals; Biological Transport; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Norepinephrine; Octopamine; Ouabain; Phenylephrine; Prazosin; Propranolol; Pulmonary Alveoli; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Up-Regulation; Water-Electrolyte Balance; Yohimbine

2004
The antinociceptive activity of intrathecally administered amiloride and its interactions with morphine and clonidine in rats.
    The journal of pain, 2012, Volume: 13, Issue:1

    Topics: Amiloride; Analgesics; Animals; Area Under Curve; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hyperalgesia; Injections, Spinal; Male; Morphine; Motor Activity; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Sodium Channel Blockers; Time Factors

2012