clonazepam has been researched along with pk 11195 in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (33.33) | 18.7374 |
| 1990's | 35 (50.72) | 18.2507 |
| 2000's | 9 (13.04) | 29.6817 |
| 2010's | 1 (1.45) | 24.3611 |
| 2020's | 1 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Campiani, G; Ciani, SM; De Filippis, MP; Fiorini, I; Garofalo, A; Greco, G; Manzoni, C; Mennini, T; Mihai, C; Nacci, V; Novellino, E; Williams, DC; Woods, MJ; Zisterer, DM | 1 |
| Campiani, G; Fiorini, I; Goegan, M; Mennini, T; Morelli, E; Nacci, V; Novellino, E; Ramunno, A; Sullivan, S; Williams, CD; Zisterer, DM | 1 |
| Cleary, J; Glick, GD; Johnson, KM; Opipari, AW | 1 |
| Baglini, E; Barresi, E; Robello, M; Salerno, S; Settimo, FD; Taliani, S | 1 |
| Järvinen, A; Männistö, PT; Rägo, L | 1 |
| Berdeu, D; Loubatières-Mariani, MM; Manteghetti, M; Petit, P; Ribes, G | 1 |
| Järvinen, A; Männistö, PT; Paakkari, I | 1 |
| Becker, DP; Black, KL; Ikezaki, K; Shiraishi, T | 1 |
| Abraham, S; Bolger, GT; Oz, N; Weissman, BA | 1 |
| Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV | 1 |
| De Luca, C; De Medici, D; Massotti, M | 1 |
| Elgoyhen, AB; Kazanietz, MG | 1 |
| O'Beirne, GB; Williams, DC; Woods, MJ | 1 |
| De Luca, C; Massotti, M; Mele, L | 1 |
| Adler-Graschinsky, E; Elgoyhen, B | 1 |
| Daval, JL; Marangos, PJ; Post, RM | 1 |
| Bachy, A; Cordeau, LR; Croizat, BP; Gros, F; Keane, PE; Larcher, JC; Le Marquer, FJ; Vayssiere, JL | 1 |
| Black, KL; Ikezaki, K; Toga, AW | 1 |
| Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC | 1 |
| Duerson, KC; Gerrish, KE; Laird, HE; Putnam, CW; Russell, DH | 1 |
| Calandra, RS; Ritta, MN | 1 |
| Salmona, M; Tacconi, MT | 1 |
| Ciliax, BJ; Mancini, WR; Olson, JM; Young, AB | 1 |
| Randall, JI; Rodgers, RJ | 1 |
| Anholt, RR; De Souza, EB; Kuhar, MJ; Murphy, KM; Snyder, SH | 1 |
| Paul, SM; Pert, CB; Ruff, MR; Wahl, LM; Wahl, SM; Weber, RJ | 1 |
| Fares, F; Gavish, M | 1 |
| Belin, C; Carriot, T; Dubroeucq, MC; Guérémy, C; Le Fur, G; Mestre, M; Renault, C; Uzan, A | 2 |
| Bryere, P; Naquet, R; Valin, A | 1 |
| Lafaille, F; Lal, S; Nair, NP; Quirion, R; Suranyi-Cadotte, B | 1 |
| Lenfant, M; Zavala, F | 1 |
| French, JF; Grupp, IL; Matlib, MA | 1 |
| Benavides, J; Dubroeucq, MC; Flamier, A; Guérémy, C; Imbault, F; Le Fur, G; Perrier, ML; Renault, C; Uzan, A; Vaucher, N | 1 |
| Benavides, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Renault, C; Rufat, P; Uzan, A | 1 |
| Benavides, J; Dubroeucq, MC; Flamier, A; Guérémy, C; Le Fur, G; Perrier, ML; Renault, C; Uzan, A; Vaucher, N | 1 |
| Butlen, D | 1 |
| Ekström, P; Grossmann, E; Meissl, H; Yáñez, J | 1 |
| Niles, LP; Tenn, CC | 1 |
| Antonenko, YN; Kinnally, KW; McEnery, MW; Snyder, SH; Tedeschi, H; Zorov, DB | 1 |
| Itzhak, Y; Norenberg, MD | 1 |
| Matthews, EK; Ratcliffe, SL | 1 |
| Fritz-Zieroth, B; Fukui, M; Ikezaki, K; Inamura, T; Nomura, T; Takahashi, M | 1 |
| Koga, K; Matsumoto, T; Ogata, M; Shigematsu, A | 1 |
| Auta, J; Costa, E; Guidotti, A; Kozikowski, A; Ma, D; Romeo, E | 1 |
| Armando, I; Barontini, MB; Lemoine, AP; Segura, ET | 1 |
| MacGregor, DG; Miller, WJ; Stone, TW | 1 |
| Lichtensteiger, W; Ramseier, H; Schlumpf, M | 1 |
| Kwan, YW; Ngan, MP; Yiu, MK | 1 |
| Cespuglio, R; Miachon, S | 1 |
| Bessler, H; Caspi, B; Gavish, M; Rehavi, M; Weizman, A | 1 |
| Boujrad, N; Kotoula, M; Kozikowski, AP; Ma, D; Papadopoulos, V; Tückmantel, W | 1 |
| Gavish, M; Kelly-Hershkovitz, E; Lahav, M; Leschiner, S; Spanier, I; Weisinger, G; Weizman, R | 1 |
| Butterworth, RF; Rao, VL | 1 |
| Caldiroli, E; Cattaneo, S; Cosentino, M; Di Grazia, L; Frigo, G; Lecchini, S; Marino, F | 1 |
| Beery, E; Brenner, S; Gavish, M; Landau, M; Landau, O; Nordenberg, J; Wasseman, L; Weizman, A; Zoref-Shani, E | 1 |
| Blanc, F; Butterworth, RF; Fabbro-Peray, P; Lavoie, J; Layrargues, GP; Mousseau, DD; Perney, P | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Leeuwin, RS; van Wilgenburg, H; Zeegers, A | 1 |
| Fornai, F; Gesi, M; Lenzi, P; Natale, G; Paparelli, A; Pellegrini, A; Riva, A; Soldani, P | 1 |
| Bono, F; Herbert, JM; Lamarche, I; Le Fur, G; Prabonnaud, V | 1 |
| Bruni, F; Ciciani, G; Costa, B; Costagli, C; Costanzo, A; Guerrini, G; Martini, C; Selleri, S | 1 |
| Kleinrok, Z; Rajtar, G; Zółkowska, D | 1 |
| Barthel, B; Carayon, P; Faiss, S; Grabowski, P; Höpfner, M; Maaser, K; Scherübl, H; Sutter, AP; Zeitz, M | 1 |
| Jayakumar, AR; Norenberg, MD; Panickar, KS | 1 |
| Dagli, ML; Fonseca, ES; Leite, KR; Massoco, CO; Matsuzaki, P; Oloris, SC; Otake, AH; Palermo-Neto, J; Sakai, M | 1 |
| Lopes, DV; Mendonça-Silva, DL; Noël, F; Thibaut, JP | 1 |
| Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Dhir, A; Rogawski, MA | 1 |
1 review(s) available for clonazepam and pk 11195
| Article | Year |
|---|---|
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.
Topics: Amides; Animals; Cell Line, Tumor; Chemistry, Pharmaceutical; Humans; Ketones | 2021 |
68 other study(ies) available for clonazepam and pk 11195
| Article | Year |
|---|---|
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Topics: Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Isoquinolines; Ligands; Mice; Rats; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Topics: Animals; Azepines; Binding Sites; Binding, Competitive; Cell Line; Cerebral Cortex; Hydrogen Bonding; In Vitro Techniques; Ligands; Male; Mitochondria; Molecular Probes; Oxazepines; Progesterone; Rats; Receptors, GABA-A; Steroids; Structure-Activity Relationship; Testis | 2002 |
Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzodiazepines; Cell Line, Tumor; Cell Proliferation; GABA-A Receptor Antagonists; Humans; Hydrolysis; Isoquinolines; Kinetics; Ligands; Mitochondria; Proton-Translocating ATPases; Structure-Activity Relationship | 2007 |
Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion.
Topics: Animals; Benzodiazepinones; Carbolines; Clonazepam; Cold Temperature; Diazepam; Flumazenil; Hypothalamo-Hypophyseal System; Isoquinolines; Male; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Secretory Rate; Thyrotropin; Thyrotropin-Releasing Hormone | 1992 |
Effects of a peripheral-type benzodiazepine on glucose-induced insulin secretion.
Topics: Animals; Benzodiazepinones; Clonazepam; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Perfusion; Rats; Rats, Wistar | 1992 |
Central and peripheral type benzodiazepine ligands displace [3H][3-ME-HIS2]TRH from its binding sites in the brain and the anterior pituitary and antagonize the effect of TRH in the rat duodenum.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Brain Stem; Carbolines; Clonazepam; Diazepam; Duodenum; Hypothalamus; Isoquinolines; Male; Muscle, Smooth; Pituitary Gland, Anterior; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Thyrotropin-Releasing Hormone | 1991 |
Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells.
Topics: Animals; Benzodiazepinones; Cell Line; Clonazepam; Culture Media, Serum-Free; Fluorescent Dyes; Glioma; Isoquinolines; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Rats; Receptors, GABA-A; Rhodamine 123; Rhodamines | 1991 |
Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzodiazepinones; Blood Pressure; Calcium Channels; Clonazepam; Coronary Disease; Electrocardiography; Guinea Pigs; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Receptors, GABA-A | 1990 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthesia; Animals; Ataxia; Benzodiazepines; Brain; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Flurazepam; GABA-A Receptor Antagonists; Isoquinolines; Male; Mice; Midazolam; Nitrendipine; Seizures | 1991 |
Relative efficacies of benzodiazepine receptor agonists in affecting red nucleus electrical activity in rabbits.
Topics: Animals; Bicuculline; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Imidazoles; Isoquinolines; Male; Pentylenetetrazole; Pyridazines; Pyridines; Rabbits; Receptors, GABA-A; Red Nucleus; Zolpidem | 1990 |
Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Bicuculline; Clonazepam; Convulsants; Diazepam; Estradiol; Estrogens; Female; Flumazenil; In Vitro Techniques; Isoquinolines; Muscle, Smooth; Potassium Chloride; Propranolol; Rats; Rats, Inbred Strains; Uterine Contraction | 1990 |
Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver.
Topics: Affinity Labels; Animals; Benzodiazepinones; Catalase; Centrifugation, Density Gradient; Clonazepam; Electrophoresis, Polyacrylamide Gel; Glutamate Dehydrogenase; Intracellular Membranes; Isoquinolines; Liver; Mitochondria, Liver; Polyethyleneimine; Rats; Receptors, GABA-A; Sonication; Subcellular Fractions; Succinate Dehydrogenase | 1990 |
Involvement of the "peripheral" benzodiazepine receptor type (omega 3) in the tolerance to the electroencephalographic effects of benzodiazepines in rats: comparison of diazepam and clonazepam.
Topics: Animals; Benzodiazepinones; Clonazepam; Diazepam; Drug Tolerance; Electroencephalography; Isoquinolines; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Diminution by benzodiazepines of the chronotropic responses to noradrenaline in rat isolated atria.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Colforsin; Cyclic AMP; Diazepam; Female; Flumazenil; Heart; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Pyruvate dehydrogenase interactions with peripheral-type benzodiazepine receptors.
Topics: Animals; Benzodiazepinones; Brain; Clonazepam; Isoquinolines; Ketoglutarate Dehydrogenase Complex; Male; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility | 1989 |
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
Topics: Animals; Benzodiazepines; Cells, Cultured; Clonazepam; Clone Cells; Diazepam; Flumazenil; Isoquinolines; Mice; Mitochondria; Neuroblastoma; Oxygen Consumption; Receptors, GABA-A | 1989 |
Imaging of brain tumors using peripheral benzodiazepine receptor ligands.
Topics: Animals; Autoradiography; Brain Neoplasms; Clonazepam; Female; Flunitrazepam; Glioma; Image Processing, Computer-Assisted; Isoquinolines; Ligands; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma; Isoquinolines; Mice; Neuroblastoma; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 1989 |
Peripheral benzodiazepine binding sites in Nb 2 node lymphoma cells: effects on prolactin-stimulated proliferation and ornithine decarboxylase activity.
Topics: Benzodiazepinones; Cell Division; Clonazepam; Humans; Isoquinolines; Kinetics; Lymph Nodes; Lymphoma; Ornithine Decarboxylase; Prolactin; Receptors, GABA-A; Thymidine; Tumor Cells, Cultured | 1989 |
Testicular interstitial cells as targets for peripheral benzodiazepines.
Topics: Animals; Benzodiazepinones; Clonazepam; Diazepam; In Vitro Techniques; Isoquinolines; Leydig Cells; Male; Rats; Rats, Inbred Strains; Testosterone | 1989 |
Differential effects of benzodiazepines on phospholipid methylation in hippocampus and cerebellum of rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Membrane; Cerebellum; Clonazepam; Hippocampus; Isoquinolines; Male; Methylation; Methyltransferases; Neurons; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Phospholipids; Rats; Receptors, GABA-A; Synaptosomes | 1988 |
Presence of peripheral-type benzodiazepine binding sites on human erythrocyte membranes.
Topics: Benzodiazepinones; Clonazepam; Convulsants; Erythrocyte Membrane; Flunitrazepam; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Monoamine Oxidase; Receptors, GABA-A | 1988 |
Blockade of non-opioid analgesia in intruder mice by selective neuronal and non-neuronal benzodiazepine recognition site ligands.
Topics: Aggression; Analgesia; Animals; Benzodiazepinones; Clonazepam; Convulsants; Isoquinolines; Ligands; Male; Mice; Mice, Inbred DBA; Neurons; Nociceptors; Reaction Time; Receptors, GABA-A | 1988 |
Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis.
Topics: Adrenal Glands; Animals; Autoradiography; Benzodiazepinones; Binding, Competitive; Clonazepam; Isoquinolines; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, GABA-A; Testis; Tissue Distribution | 1985 |
Benzodiazepine receptor-mediated chemotaxis of human monocytes.
Topics: Benzodiazepinones; Binding, Competitive; Chemotaxis, Leukocyte; Clonazepam; Humans; Isoquinolines; Monocytes; Receptors, GABA-A | 1985 |
Solubilization of peripheral benzodiazepine-binding sites from rat kidney.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Carbolines; Chlordiazepoxide; Clonazepam; Diazepam; Digitonin; Flumazenil; Flurazepam; Guanidine; Guanidines; Hot Temperature; Isoquinolines; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility; Time Factors; Urea | 1985 |
Pharmacology of peripheral type benzodiazepine receptors in the heart.
Topics: Action Potentials; Animals; Benzodiazepinones; Clonazepam; Convulsants; Diazepam; Electric Stimulation; Guinea Pigs; Heart; Heart Ventricles; Isoquinolines; Kinetics; Myocardial Contraction; Myocardium; Receptors, GABA-A; Ventricular Function | 1985 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Isoquinolines; Papio; Receptors, GABA-A; Seizures | 1986 |
Coexistence of central and peripheral benzodiazepine binding sites in the human pineal gland.
Topics: Aged; Benzodiazepinones; Binding, Competitive; Cell Membrane; Clonazepam; Female; Flumazenil; Flunitrazepam; Humans; Isoquinolines; Male; Middle Aged; Pineal Gland; Receptors, GABA-A | 1987 |
Peripheral benzodiazepines enhance the respiratory burst of macrophage-like P388D1 cells stimulated by arachidonic acid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzodiazepinones; Cell Line; Clonazepam; Diazepam; Isoquinolines; Kinetics; Macrophages; Receptors, GABA-A; Superoxides | 1987 |
Benzodiazepine Ro 5-4864 increases coronary flow.
Topics: Animals; Benzodiazepinones; Clonazepam; Convulsants; Coronary Circulation; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Rats; Rats, Inbred Strains | 1987 |
Electrophysiological and pharmacological characterization of peripheral benzodiazepine receptors in a guinea pig heart preparation.
Topics: Action Potentials; Animals; Benzodiazepinones; Clonazepam; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Flumazenil; Guinea Pigs; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Myocardium; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies.
Topics: Adrenal Glands; Animals; Benzodiazepinones; Blood Platelets; Brain; Clonazepam; Diazepam; In Vitro Techniques; Isoquinolines; Kidney; Male; Myocardium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1983 |
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies.
Topics: Animals; Benzodiazepinones; Brain; Clonazepam; Diazepam; Isoquinolines; Kidney; Kinetics; Male; Mice; Myocardium; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies.
Topics: Animals; Benzodiazepinones; Clonazepam; Diazepam; Dipyridamole; Isoquinolines; Ligands; Male; Membranes; Myocardium; Rats; Receptors, Cell Surface; Receptors, GABA-A; Thermodynamics | 1983 |
Benzodiazepine receptors along the nephron: [3H]PK 11195 binding in rat tubules.
Topics: Animals; Benzodiazepinones; Clonazepam; Dose-Response Relationship, Drug; Isoquinolines; Kidney Tubules; Male; Nephrons; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1984 |
Benzodiazepines influence melatonin secretion of the pineal organ of the trout in vitro.
Topics: 5-Methoxytryptamine; Animals; Benzodiazepines; Calcium; Clonazepam; Culture Media; Dark Adaptation; Diazepam; Flumazenil; Hydroxyindoleacetic Acid; In Vitro Techniques; Indoles; Isoquinolines; Light; Magnesium; Melatonin; Oncorhynchus mykiss; Pineal Gland | 1994 |
Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism.
Topics: Animals; Apomorphine; Behavior, Animal; Bicuculline; Clonazepam; Corpus Striatum; Dopamine Agonists; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Isoquinolines; Male; Melatonin; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.
Topics: Animals; Benzodiazepinones; Clonazepam; Convulsants; Flumazenil; Intracellular Membranes; Ion Channels; Isoquinolines; Male; Membrane Potentials; Mitochondria, Heart; Protoporphyrins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Submitochondrial Particles | 1993 |
Attenuation of ammonia toxicity in mice by PK 11195 and pregnenolone sulfate.
Topics: Ammonia; Animals; Clonazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Male; Mice; Pregnenolone | 1994 |
Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands.
Topics: Aminolevulinic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Survival; Clonazepam; Flumazenil; Isoquinolines; Ligands; Mitochondria; Oxygen; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Radiation-Protective Agents; Radiation-Sensitizing Agents; Rats; Receptors, GABA-A; Singlet Oxygen; Tumor Cells, Cultured | 1995 |
Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors.
Topics: Animals; Brain Neoplasms; Clonazepam; Contrast Media; Glioma; Isoquinolines; Kidney; Magnetic Resonance Imaging; Male; Porphyrins; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Receptors, GABA-A; Tissue Distribution | 1994 |
Effect of peripheral benzodiazepine receptor ligands on lipopolysaccharide-induced tumor necrosis factor activity in thioglycolate-treated mice.
Topics: Animals; Benzodiazepinones; Clonazepam; GABA-A Receptor Antagonists; Isoquinolines; Ligands; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Midazolam; Receptors, GABA-A; Thioglycolates; Tumor Necrosis Factor-alpha | 1994 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Clonazepam; Desoxycorticosterone; Flumazenil; Imidazoles; Indoleacetic Acids; Isoniazid; Isoquinolines; Mitochondria; Phobic Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Seizures; Zolpidem | 1993 |
The stress-induced reduction in monoamine oxidase (MAO) A activity is reversed by benzodiazepines: role of peripheral benzodiazepine receptors.
Topics: Analysis of Variance; Animals; Brain; Clonazepam; Electroshock; Isoenzymes; Isoquinolines; Lorazepam; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Values; Stress, Psychological | 1993 |
Mediation of the neuroprotective action of R-phenylisopropyl-adenosine through a centrally located adenosine A1 receptor.
Topics: Animals; Clonazepam; Hippocampus; Isoquinolines; Kainic Acid; Male; Neurons; Phenylisopropyladenosine; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Purinergic P1; Theophylline | 1993 |
In vitro inhibition of cellular immune responses by benzodiazepines and PK 11195. Effects on mitogen- and alloantigen-driven lymphocyte proliferation and on IL-1, IL-2 synthesis and IL-2 receptor expression.
Topics: Animals; B-Lymphocytes; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Female; Flumazenil; Immunity, Cellular; In Vitro Techniques; Interleukin-1; Interleukin-2; Isoquinolines; Lymphocyte Activation; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Neuroimmunomodulation; Receptors, GABA-A; T-Lymphocytes | 1993 |
Hormonal modulation of benzodiazepines' actions on rat isolated uterus.
Topics: Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Estrogens; Female; Isoquinolines; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Uterine Contraction; Uterus | 1996 |
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aggression; Animals; Benzodiazepinones; Clonazepam; Flumazenil; GABA Modulators; Isoquinolines; Male; Mice; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; Time Factors | 1997 |
Significant inhibition of spontaneous IgA secretion by selective peripheral-type benzodiazepine receptor ligands.
Topics: Anti-Anxiety Agents; Antibody-Producing Cells; B-Lymphocytes; Clonazepam; Diazepam; Flunitrazepam; GABA-A Receptor Antagonists; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Isoquinolines; Lymphocyte Activation | 1997 |
Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptor.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Benzodiazepinones; Biological Transport; Cholesterol; Clonazepam; Fluorescent Dyes; Hypolipidemic Agents; Indoleacetic Acids; Isoquinolines; Ligands; Male; Mice; Microscopy, Fluorescence; Mitochondria; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 1997 |
Effects of peripheral-type benzodiazepine receptor antisense knockout on MA-10 Leydig cell proliferation and steroidogenesis.
Topics: Algestone; Androstenedione; Animals; Benzodiazepinones; Cell Division; Clonazepam; Cyclic AMP; DNA, Antisense; GABA-A Receptor Antagonists; Isoquinolines; Leydig Cells; Male; Mice; Plasmids; Progesterone; Protein Binding; Receptors, GABA-A; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1998 |
Characterization of binding sites for the omega3 receptor ligands [3H]PK11195 and [3H]RO5-4864 in human brain.
Topics: Allosteric Regulation; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Clonazepam; Convulsants; Detergents; Diazepam; Dithiothreitol; Female; Histidine; Humans; Isoquinolines; Ligands; Male; Occipital Lobe; Receptors, GABA-A; Sulfhydryl Reagents; Tritium | 1997 |
Modulation of intracellular calcium in human neutrophils by peripheral benzodiazepine receptor ligands.
Topics: Anti-Anxiety Agents; Benzodiazepinones; Calcium; Clonazepam; Cytosol; Diazepam; Drug Antagonism; GABA Modulators; Humans; Isoquinolines; Neutrophils; Receptors, GABA-A | 1998 |
Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.
Topics: Animals; Antineoplastic Agents; Benzodiazepinones; Cell Cycle; Cell Differentiation; Cell Division; Clonazepam; Diazepam; GABA Agents; gamma-Glutamyltransferase; Isoquinolines; Melanoma, Experimental; Mice; Nucleotides; Phenotype; Tumor Cells, Cultured | 1998 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clonazepam; Diazepam; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Humans; Isoquinolines; Liver Cirrhosis; Oxazepam; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study.
Topics: Animals; Benzodiazepines; Cardiac Output; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Perfusion; Pyridines; Rats; Receptors, GABA-A; Zolpidem | 1998 |
Central and peripheral benzodiazepine ligands prevent mitochondrial damage induced by noise exposure in the rat myocardium: an ultrastructural study.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; GABA Modulators; Isoquinolines; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Mitochondria, Heart; Myocardium; Noise; Rats; Rats, Wistar; Time Factors | 1999 |
Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities.
Topics: Apoptosis; Benzodiazepinones; Clonazepam; Diazepam; Flunitrazepam; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Isoquinolines; Jurkat Cells; Kinetics; Ligands; Receptors, GABA-A; Transfection; Tumor Necrosis Factor-alpha; U937 Cells | 1999 |
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Topics: Acetamides; Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Clonazepam; Flumazenil; Glioma; Intracellular Membranes; Isoquinolines; Kidney; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrazoles; Pyrimidines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Thermodynamics; Tumor Cells, Cultured | 2001 |
Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Blood Platelets; Calcium Signaling; Clonazepam; Diazepam; Drug Interactions; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, GABA-A; Respiratory Burst; Thrombin | 2002 |
Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells.
Topics: Aged; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspases; Cell Cycle; Cell Division; Clonazepam; Dose-Response Relationship, Drug; Esophageal Neoplasms; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Indoleacetic Acids; Isoquinolines; Ligands; Male; Middle Aged; Receptors, GABA-A; Tumor Cells, Cultured | 2002 |
Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells.
Topics: Animals; Antioxidants; Astrocytes; Benzodiazepinones; Binding, Competitive; Cells, Cultured; Clonazepam; Cyclosporine; Dose-Response Relationship, Drug; Free Radicals; Isoquinolines; Ligands; Microglia; Mitochondria; Neurons; Protoporphyrins; Rats; Receptors, GABA-A | 2002 |
Effects of peripheral-type benzodiazepine receptor ligands on Ehrlich tumor cell proliferation.
Topics: Animals; Benzodiazepinones; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Division; Cell Proliferation; Clonazepam; Flow Cytometry; GABA Modulators; Immunohistochemistry; Isoquinolines; Ligands; Mice; Receptors, GABA-A | 2006 |
Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Clonazepam; Diazepam; Flunitrazepam; GABA Agonists; GABA Modulators; Inhibitory Concentration 50; Isoquinolines; Ligands; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Schistosoma mansoni; Synaptosomes; Temperature; Time Factors; Tritium; Zolpidem | 2007 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological | 2008 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Finasteride; GABA Antagonists; Isoquinolines; Male; Mice; Midazolam; Neurotransmitter Agents; Pentylenetetrazole; Receptors, GABA; Seizures | 2012 |