clomipramine and nortriptyline

clomipramine has been researched along with nortriptyline in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (45.45)	18.7374
1990's	13 (16.88)	18.2507
2000's	15 (19.48)	29.6817
2010's	13 (16.88)	24.3611
2020's	1 (1.30)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Chiang, GH; Unger, SH	1
Horvath, D	1
Medina-Hernández, MJ; Quiñones-Torrelo, C; Sagrado, S; Villanueva-Camañas, RM	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Ikeda, K; Kobayashi, T; Washiyama, K	1
Chang, TK; Ensom, MH; Kiang, TK	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Hajjo, R; Roth, BL; Setola, V; Tropsha, A	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cardoso, FC; Duggan, PJ; Kuiper, MJ; Lewis, RJ; Schmit, M; Tuck, KL	1
Asberg, M	2
Sjöström, R; Wide, L; Widerlöv, E	1
Dujovne, CA; Ueda, I; Yasuhara, H	1
Leppäluoto, J; Linnoila, M; Ranta, T; Seppälä, T	1
Moyes, IC; Moyes, RB	2
Baba, O; Fujiwara, J; Hanaoka, M; Ishino, H; Sasaki, K	1
Detaevernier, MR; Dryon, L; Massart, DL	1
Oksenkrug, GF	1
Blanchi, M; De Conno, F; Panerai, AE; Ripamonti, C; Sacerdote, P; Ventafridda, V; Zecca, E	1
Insel, TR; Winslow, JT	1
Bianchi, M; Francucci, BM; Monza, G; Movilia, P; Panerai, AE; Tiengo, M	1
Bryan, W; Fraser, AD; Isner, AF	1
Iri, H; Kanba, S; Kubo, H; Matsumoto, K; Yagi, G; Yuki, H	1
Brini, A; Mantegazza, P; Panerai, AE; Sacerdote, P	1
Fuwano, S; Itoh, N; Matsui, N; Miyashita, O; Sakai, M; Yaginuma, H	1
Domínguez-Gil, A; Fernández de Gatta, MM; García, MJ; Gutierrez, JR; Tamayo, M	1
Ananth, J	1
Ericsson, O; Nordin, C; Spina, E	1
Asberg, M; Bertilsson, L; Thorén, P	1
Bareggi, SR; Bonaccorsi, A; Franco, R; Garattini, S; Morselli, PL; Mundo, AS; Riva, E	1
Liljequist, R; Linnoila, M; Mattila, MJ	1
Bianchetti, G; Dugas, M; Morselli, PL	1
Insel, TR; Murphy, DL	1
Crews, FT; Smith, CB	1
Gram, LF; Kragh-Sørensen, P; Kristensen, CB; Møller, M; Pedersen, OL; Thayssen, P	1
Phillis, JW	1
Itoh, M; Nakao, H; Notomi, A; Yufu, N	1
Vinet, B	1
Briley, MS; Langer, SZ; Sette, M	1
Anderson, JA; Brodie, NH; McGhie, RL; O'Hara, H; O'Hara, J; Schiff, AA; Valle-Jones, JC	1
Elonen, E; Linnoila, M; Mattila, MJ; Seppala, T; Soundergaard, I	1
Bazán, E; Fuentes, JA; Galindo, A; Guillamón, A; Somoza, E; Valencia, A	1
Moyes, IC; Moyes, RB; Ray, RL	1
Asberg, M; Cronholm, B; Jörnestedt, L; Thorén, P; Träskman, L	1
Brodin, E; Brodin, K; Ogren, SO	1
Bianchi, M; Panerai, AE; Sacerdote, P	1
Coutts, RT	1
Bech, P; Gjerris, A; Kragh-Sørensen, P; Larsen, JK; Nair, NP; Stage, KB	1
Ballesta, J; de la Torre, R; González, S; Ortuño, J; Pascual, JA	1
Akhondzadeh, S; Hosseini, SH; Mohammadi, MR; Noorbala, AA	1
Cerniglia, CE; Dovichi, NJ; Hansen, EB; Li, XF; Liu, CS; Roos, P	1
Meyers, BS	1
Joyce, PR; Luty, SE; Mulder, RT; Watkins, WG	1
DeVane, CL; Loughhead, AM; Newport, DJ; Owens, MJ; Ritchie, JC; Stowe, ZN	1
Bastías A, MJ; Olmos C, P; Toro C, L	1
Bertilsson, L	1
Alves, C; Fernandes, C; Lanças, FM; Rodrigues, JC; Santos-Neto, AJ	1
Akram, M; Al-Ahmadi, MD; Naqvi, AZ	1
Amberger-Murphy, V; Cree, IA; Glaysher, S; Hurren, J; Knight, LA; McCormick, D; Parker, KA; Pilkington, GJ; Suovouri, A	1
Kofune, M; Kofune, T; Ohkubo, K; Watanabe, I	1
Aldington, D; Derry, S; Moore, RA; Wiffen, PJ	1
Berm, EJJ; Brummel-Mulder, E; Hak, E; Maring, JG; Paardekooper, J; Wilffert, B	1
Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X	1

Reviews

11 review(s) available for clomipramine and nortriptyline

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clomipramine: an antiobsessive drug. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:3 Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive Disorder; Diazepam; Haloperidol; Humans; Imipramine; Nortriptyline; Obsessive Behavior; Obsessive-Compulsive Disorder; Phobic Disorders; Psychological Tests	1986
Individualization of treatment with tricyclic compounds. The Medical clinics of North America, 1974, Volume: 58, Issue:5 Topics: Animals; Antidepressive Agents; Chromatography, Gas; Clomipramine; Depression; Drug Interactions; Electrocardiography; Humans; Imipramine; Kinetics; Norepinephrine; Nortriptyline; Rats; Serotonin; Time Factors	1974
The psychopharmacological treatment of obsessive-compulsive disorder: a review. Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:5 Topics: Anti-Anxiety Agents; Antipsychotic Agents; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Humans; Hydroxyindoleacetic Acid; Nortriptyline; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales	1981
Plasma level monitoring of antidepressants: theoretical basis and clinical application. Advances in biochemical psychopharmacology, 1984, Volume: 39 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Genetic Variation; Humans; Imipramine; Kinetics; Nortriptyline; Oxidation-Reduction; Patient Compliance; Pharmacogenetics	1984
Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping. Journal of psychiatry & neuroscience : JPN, 1994, Volume: 19, Issue:1 Topics: Clomipramine; Cytochromes; Dealkylation; Depressive Disorder; Desipramine; Dextromethorphan; Drug Interactions; Female; Humans; Hydroxylation; Imipramine; Isoenzymes; Male; Mephenytoin; Nortriptyline; Phenotype; Polymorphism, Genetic	1994
Depression and dementia: comorbidities, identification, and treatment. Journal of geriatric psychiatry and neurology, 1998,Winter, Volume: 11, Issue:4 Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Benzamides; Citalopram; Clomipramine; Cognition Disorders; Comorbidity; Dementia; Depression; Female; Fluoxetine; Fluvoxamine; Humans; Imipramine; Male; Middle Aged; Moclobemide; Monoamine Oxidase Inhibitors; Neuropsychological Tests; Nortriptyline; Selective Serotonin Reuptake Inhibitors; Sertraline	1998
Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects. Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5 Topics: Antidepressive Agents; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Asian People; Clomipramine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Ethnicity; Humans; Mediterranean Region; Metabolic Networks and Pathways; Mixed Function Oxygenases; Mutation; Nortriptyline; Polymorphism, Genetic; Sweden; White People	2007
Nortriptyline for neuropathic pain in adults. The Cochrane database of systematic reviews, 2015, Jan-08, Volume: 1 Topics: Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Morphine; Neuralgia; Nortriptyline; Pregabalin; Randomized Controlled Trials as Topic	2015
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047 Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride	2016

Trials

11 trial(s) available for clomipramine and nortriptyline

Article	Year
Effects of tricyclic antidepressants on human plasma levels of TSH, GH and prolactin. Acta psychiatrica Scandinavica, 1978, Volume: 58, Issue:5 Topics: Adult; Clomipramine; Dibenzazepines; Growth Hormone; Humans; Male; Nortriptyline; Prolactin; Radioimmunosorbent Test; Thyrotropin; Thyrotropin-Releasing Hormone	1978
A randomized, within-patient, cross-over, placebo-controlled trial on the efficacy and tolerability of the tricyclic antidepressants chlorimipramine and nortriptyline in central pain. Acta neurologica Scandinavica, 1990, Volume: 82, Issue:1 Topics: Adult; Clomipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Placebos	1990
Clomipramine: an antiobsessive drug. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:3 Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive Disorder; Diazepam; Haloperidol; Humans; Imipramine; Nortriptyline; Obsessive Behavior; Obsessive-Compulsive Disorder; Phobic Disorders; Psychological Tests	1986
Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression. European journal of clinical pharmacology, 1974, Aug-23, Volume: 7, Issue:5 Topics: Clomipramine; Depression; Dibenzazepines; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Norepinephrine; Nortriptyline; Placebos; Serotonin	1974
Effect of two weeks treatment with chlorimipramine and nortriptyline, alone or in combination with alcohol on learning and memory. Psychopharmacologia, 1974, Volume: 39, Issue:2 Topics: Adult; Blood Pressure; Clomipramine; Dibenzazepines; Drug Synergism; Ethanol; Humans; Learning; Male; Memory; Memory, Short-Term; Nortriptyline; Placebos; Receptors, Adrenergic; Tyramine	1974
The psychopharmacological treatment of obsessive-compulsive disorder: a review. Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:5 Topics: Anti-Anxiety Agents; Antipsychotic Agents; Clinical Trials as Topic; Clomipramine; Double-Blind Method; Humans; Hydroxyindoleacetic Acid; Nortriptyline; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales	1981
Doctor's versus patient's judgement in the assessment of mixed anxiety/depressive illness. Implications for measurement of therapeutic response. Acta psychiatrica Scandinavica, 1981, Volume: 63, Issue:5 Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Clomipramine; Depression; Drug Combinations; Female; Fluphenazine; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales; Random Allocation; Self-Assessment	1981
Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial. Archives of general psychiatry, 1980, Volume: 37, Issue:11 Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales	1980
The Major Depression Rating Scale (MDS). Inter-rater reliability and validity across different settings in randomized moclobemide trials. Danish University Antidepressant Group. Journal of affective disorders, 1997, Volume: 42, Issue:1 Topics: Antidepressive Agents; Benzamides; Clomipramine; Depressive Disorder; Drug Therapy, Combination; Humans; Isocarboxazid; Moclobemide; Nortriptyline; Observer Variation; Personality Inventory; Psychometrics; Reproducibility of Results	1997
Combination of clomipramine and nortriptyline in the treatment of obsessive-compulsive disorder: a double-blind, placebo-controlled trial. Journal of clinical pharmacy and therapeutics, 1998, Volume: 23, Issue:2 Topics: Adrenergic Uptake Inhibitors; Adult; Clomipramine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Nortriptyline; Obsessive-Compulsive Disorder; Placebos; Selective Serotonin Reuptake Inhibitors	1998
Age may affect response to antidepressants with serotonergic and noradrenergic actions. Journal of affective disorders, 2003, Volume: 76, Issue:1-3 Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Nortriptyline; Treatment Outcome	2003

Other Studies

57 other study(ies) available for clomipramine and nortriptyline

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
A virtual screening approach applied to the search for trypanothione reductase inhibitors. Journal of medicinal chemistry, 1997, Jul-18, Volume: 40, Issue:15 Topics: Algorithms; Databases, Factual; Enzyme Inhibitors; Models, Chemical; Molecular Conformation; NADH, NADPH Oxidoreductases; Thermodynamics	1997
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16 Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Enzyme Inhibitors; Histamine H1 Antagonists; Micelles; Models, Biological; Norepinephrine; Rats; Receptors, Adrenergic, alpha-1; Selective Serotonin Reuptake Inhibitors; Serotonin; Structure-Activity Relationship	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:10 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Electrophysiology; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Heart; Humans; Myocardium; Oocytes; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Xenopus laevis	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers. Journal of medicinal chemistry, 2012, Jun-28, Volume: 55, Issue:12 Topics: Alzheimer Disease; Cell Line, Tumor; Cloning, Molecular; Cognition; Drug Discovery; Drug Evaluation, Preclinical; Genomics; Humans; Informatics; Ligands; Nootropic Agents; Quantitative Structure-Activity Relationship; Raloxifene Hydrochloride; Receptors, Serotonin; Reproducibility of Results; Selective Estrogen Receptor Modulators; Serotonin Antagonists; User-Computer Interface	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain. RSC medicinal chemistry, 2022, Feb-23, Volume: 13, Issue:2 Topics:	2022
Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects. Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1976, Volume: 9, Issue:1 Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Neurons; Neurotransmitter Agents; Norepinephrine; Nortriptyline; Serotonin; Suicide; Tyramine	1976
Relationship between surface activity and toxicity to Chang liver cultures of tricyclic antidepressants. Pharmacology, 1979, Volume: 18, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cells, Cultured; Clomipramine; Doxepin; Glucuronidase; Humans; Imipramine; L-Lactate Dehydrogenase; Liver; Nortriptyline; Surface Tension	1979
Serum gonadotropin and TSH levels after tricyclic antidepressants in healthy males. Acta pharmacologica et toxicologica, 1977, Volume: 41, Issue:3 Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Doxepin; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Nortriptyline; Secretory Rate; Thyrotropin	1977
Metabolism and pharmacokinetics of clomipramine. Measurement of plasma antidepressant levels by high-performance liquid chromatography. Postgraduate medical journal, 1977, Volume: 53 Suppl 4 Topics: Amitriptyline; Chromatography, Gas; Chromatography, High Pressure Liquid; Clomipramine; Dibenzazepines; Humans; Nortriptyline	1977
Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients. Acta psychiatrica Scandinavica, 1976, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Clomipramine; Depression; Drug Evaluation; Drug Therapy, Combination; Female; Flupenthixol; Humans; Imipramine; Male; Middle Aged; Nortriptyline; Pilot Projects; Thioxanthenes; Trimipramine	1976
The separation of some tricyclic antidepressants by high-performance liquid chromatography. Journal of chromatography, 1976, Nov-17, Volume: 128, Issue:1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Clomipramine; Desipramine; Imipramine; Microchemistry; Nortriptyline; Protriptyline; Trimipramine	1976
[Effect of prothixen and related compounds on serotonin absorption by human thrombocytes]. Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 80, Issue:8 Topics: Absorption; Amitriptyline; Biological Transport; Blood Platelets; Cell Membrane Permeability; Chlorpromazine; Clomipramine; Depression, Chemical; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Serotonin; Structure-Activity Relationship; Thioxanthenes; Triazines	1975
Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain, 1990, Volume: 43, Issue:2 Topics: Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Drug Synergism; Humans; Morphine; Nortriptyline; Rats; Rats, Inbred Strains; Trazodone	1990
Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:1 Topics: Animals; Body Temperature; Catecholamines; Citalopram; Clomipramine; Desipramine; Flumazenil; Mazindol; Motor Activity; Naltrexone; Nortriptyline; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stress, Psychological; Ultrasonics; Vocalization, Animal	1990
Evaluation of the EMIT amitriptyline and nortriptyline assays for the determination of serum clomipramine and desmethylclomipramine. Therapeutic drug monitoring, 1989, Volume: 11, Issue:3 Topics: Amitriptyline; Antibody Specificity; Clomipramine; Cross Reactions; Evaluation Studies as Topic; Humans; Immunoenzyme Techniques; Indicators and Reagents; Nortriptyline	1989
Automated determination of drugs in serum by column-switching high-performance liquid chromatography. IV. Separation of tricyclic and tetracyclic antidepressants and their metabolites. Clinical chemistry, 1989, Volume: 35, Issue:3 Topics: Amitriptyline; Amoxapine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Autoanalysis; Chromatography, High Pressure Liquid; Clomipramine; Humans; Hydrogen-Ion Concentration; Maprotiline; Nortriptyline; Quality Control; Regression Analysis	1989
A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs. Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:1 Topics: 5-Hydroxytryptophan; Amitriptyline; Analgesia; Animals; Antidepressive Agents, Tricyclic; beta-Endorphin; Clomipramine; Endorphins; Nortriptyline; Rats; Rats, Inbred Strains; Serotonin	1987
Serial DST, TRH test, and TRH-like immunoreactivity measurements in major affective disorders. Biological psychiatry, 1987, Volume: 22, Issue:5 Topics: Adult; Clomipramine; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged; Mood Disorders; Nortriptyline; Radioimmunoassay; Thyrotropin; Thyrotropin-Releasing Hormone	1987
High levels of tricyclic antidepressants in conventional therapy: determinant factors. International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline; Risk Factors	1988
Analysis of tricyclic antidepressants in serum and plasma yields similar results. Therapeutic drug monitoring, 1985, Volume: 7, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dealkylation; Humans; Nortriptyline	1985
Relationships between tricyclic antidepressant concentrations, 1-3H-noradrenaline uptake and chronotropic effect in isolated rat atria. European journal of pharmacology, 1974, Volume: 28, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Carbon Radioisotopes; Chromatography, Thin Layer; Clomipramine; Dealkylation; Desipramine; Dose-Response Relationship, Drug; Doxepin; Drug Synergism; Female; Heart Atria; Heart Rate; Norepinephrine; Nortriptyline; Rats; Rats, Inbred Strains; Stimulation, Chemical; Time Factors; Tritium	1974
Therapeutic drug monitoring of psychotropic drugs in children. Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:3-4 Topics: Adolescent; Adult; Age Factors; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Child; Child, Preschool; Chlorpromazine; Clomipramine; Dose-Response Relationship, Drug; Half-Life; Haloperidol; Humans; Imipramine; Kinetics; Mental Disorders; Nortriptyline	1983
Potentiation of responses to adrenergic nerve stimulation in isolated rat atria during chronic tricyclic antidepressant administration. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:1 Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Desipramine; Electric Stimulation; Heart Atria; In Vitro Techniques; Iprindole; Male; Muscles; Nerve Endings; Norepinephrine; Nortriptyline; Rats; Receptors, Adrenergic, alpha; Stimulation, Chemical; Sympathetic Nervous System	1980
Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants. British journal of pharmacology, 1984, Volume: 83, Issue:2 Topics: Action Potentials; Adenosine; Animals; Antidepressive Agents, Tricyclic; Caffeine; Cerebral Cortex; Clomipramine; Desipramine; Drug Synergism; Iprindole; Male; Neurons; Nortriptyline; Rats; Rats, Inbred Strains	1984
Simultaneous measurement of various antidepressants in the plasma of depressed patients by high performance liquid chromatography. Folia psychiatrica et neurologica japonica, 1984, Volume: 38, Issue:1 Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents; Chromatography, High Pressure Liquid; Clomipramine; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline	1984
Column deactivation in analysis for underivatized tricyclic antidepressants by gas chromatography with use of a nitrogen detector. Clinical chemistry, 1983, Volume: 29, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Humans; Imipramine; Nitrogen; Nortriptyline	1983
Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers. Journal of neurochemistry, 1983, Volume: 40, Issue:3 Topics: Amitriptyline; Animals; Binding, Competitive; Cerebral Cortex; Clomipramine; Desipramine; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists	1983
Tyramine pressor test and cardiovascular effects of chlorimipramine and nortriptyline in healthy volunteers. Biological psychiatry, 1981, Volume: 16, Issue:1 Topics: Adult; Blood Pressure; Clomipramine; Dose-Response Relationship, Drug; Double-Blind Method; Heart Rate; Humans; Nortriptyline; Placebos; Tyramine	1981
Antidepressants inhibit enkephalin binding to synaptosome-enriched fractions of rat brain. Neuropsychobiology, 1981, Volume: 7, Issue:6 Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Imipramine; Male; Nortriptyline; Rats; Rats, Inbred Strains; Synaptosomes; Viloxazine	1981
Some factors affecting the plasma levels of tricyclic antidepressants. Postgraduate medical journal, 1980, Volume: 56 Suppl 1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Clomipramine; Delayed-Action Preparations; Drug Administration Schedule; Erythrocytes; Female; Humans; Ileum; Male; Middle Aged; Nortriptyline	1980
Plasma levels and clinical improvement--a comparative study of clomipramine and amitriptyline in depression. Postgraduate medical journal, 1980, Volume: 56 Suppl 1 Topics: Amitriptyline; Clomipramine; Depression; Female; Humans; Male; Nortriptyline	1980
Clomipramine and clonazepam increase cholecystokinin levels in rat ventral tegmental area and limbic regions. European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2 Topics: Amitriptyline; Animals; Cholecystokinin; Clomipramine; Clonazepam; Infusion Pumps, Implantable; Limbic System; Male; Nortriptyline; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Ventral Tegmental Area	1994
Chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. General pharmacology, 1994, Volume: 25, Issue:3 Topics: Antidepressive Agents; Chemotaxis, Leukocyte; Clomipramine; Fluoxetine; Fluvoxamine; Humans; In Vitro Techniques; Neutrophils; Nortriptyline	1994
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection. Therapeutic drug monitoring, 1998, Volume: 20, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Drug Monitoring; Humans; Imipramine; Linear Models; Nortriptyline; Promazine; Sensitivity and Specificity	1998
Nonaqueous capillary electrophoretic separation and thermo-optical absorbance detection of five tricyclic antidepressants and metabolism of amitriptyline by Cunninghamella elegans. Electrophoresis, 1998, Volume: 19, Issue:18 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Cunninghamella; Desipramine; Electrophoresis, Capillary; Imipramine; Molecular Structure; Nortriptyline	1998
Placental passage of tricyclic antidepressants. Biological psychiatry, 2006, Feb-01, Volume: 59, Issue:3 Topics: Antidepressive Agents, Tricyclic; Birth Weight; Clomipramine; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Nortriptyline; Pregnancy; Pregnancy Complications	2006
[Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy]. Revista medica de Chile, 2006, Volume: 134, Issue:12 Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amines; Analgesics; Clomipramine; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Longitudinal Studies; Male; Middle Aged; Neuralgia; Nortriptyline; Retrospective Studies	2006
Analysis of tricyclic antidepressant drugs in plasma by means of solid-phase microextraction-liquid chromatography-mass spectrometry. Journal of mass spectrometry : JMS, 2007, Volume: 42, Issue:10 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Chromatography, Liquid; Clomipramine; Desipramine; Humans; Imipramine; Nortriptyline; Solid Phase Microextraction; Spectrometry, Mass, Electrospray Ionization	2007
Conductometric study of antidepressant drug-cationic surfactant mixed micelles in aqueous solution. Colloids and surfaces. B, Biointerfaces, 2008, Jun-15, Volume: 64, Issue:1 Topics: Antidepressive Agents, Tricyclic; Clomipramine; Electric Conductivity; Micelles; Nortriptyline; Pharmaceutical Solutions; Surface-Active Agents; Water	2008
The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures. Anti-cancer drugs, 2012, Volume: 23, Issue:1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cell Line, Tumor; Clomipramine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Melanoma; Nortriptyline; Primary Cell Culture; Skin Neoplasms	2012
Electrocardiographic changes upon tricyclic antidepressant administration mimicking Brugada syndrome. Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:12 Topics: Antidepressive Agents, Tricyclic; Brugada Syndrome; Bundle-Branch Block; Clomipramine; Depression; Electrocardiography; Humans; Lithium; Male; Middle Aged; Nortriptyline	2013
A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine, clomipramine, and their active metabolites using LC-MS/MS. Talanta, 2015, Volume: 134 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biotransformation; Calibration; Chromatography, Liquid; Clomipramine; Depressive Disorder, Major; Dried Blood Spot Testing; Drug Monitoring; Hematocrit; Humans; Imipramine; Limit of Detection; Nortriptyline; Reproducibility of Results; Tandem Mass Spectrometry	2015