clomipramine and nomifensine

clomipramine has been researched along with nomifensine in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199017 (58.62)18.7374
1990's2 (6.90)18.2507
2000's4 (13.79)29.6817
2010's6 (20.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Biziere, K; Bouchet, MJ; Bourguignon, JJ; Kan, JP; Maghioros, G; Moire, C; Schlewer, G; Wermuth, CG; Worms, P1
Costanzo, MJ; Gardocki, JF; Maryanoff, BE; McComsey, DF; Nortey, SO; Schneider, CR; Setler, PE; Shank, RP1
Lombardo, F; Obach, RS; Waters, NJ1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Korf, J; Van Praag, HM; Van Scheyen, JD1
Anlezark, G; Meldrum, BS; Trimble, MR1
Ehsanullah, RS; Turner, P1
Bär, KI; Feuerstein, TJ; Lücking, CH; Lupp, A1
Gibb, JW; Hanson, GR; Ritter, JK; Schmidt, CJ1
Benedi, A; De Ceballos, ML; Del Rio, J; Urdin, C1
Cole, JO1
Cohen, O; Globus, M; Melamed, E; Rosenthal, J; Uzzan, A1
Adams, C; Gastpar, M; Kielholz, P; Terzani, S1
Bonanno, G; Marchi, M; Maura, G; Raiteri, M1
Schnieden, H; Stein, DM1
Devoize, JL; Eschalier, A; Pechadre, JC; Rigal, F1
Dupont, A; Merand, Y; Savard, P1
Hollister, LE1
Cicardo, VH; Osman Dick, G1
Laakmann, G1
Bonnet, JJ; Costentin, J; Leblond, B; Régo, JC; Syringas, M1
Balu, R; Davidson, C; Ellinwood, EH; Lee, TH1
Adkins, EM; Blakely, RD; Field, JR; Henry, LK; Newman, AH; Parnas, ML; Vaughan, RA; Zou, MF1

Reviews

2 review(s) available for clomipramine and nomifensine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
'Second generation' antidepressant drugs.
    Psychosomatics, 1981, Volume: 22, Issue:10

    Topics: Amoxapine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clomipramine; Humans; Maprotiline; Mianserin; Nomifensine; Trazodone; Viloxazine

1981

Trials

2 trial(s) available for clomipramine and nomifensine

ArticleYear
Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Adult; Clinical Trials as Topic; Clomipramine; Depression; Dibenzazepines; Double-Blind Method; Female; Homovanillic Acid; Humans; Isoquinolines; Male; Middle Aged; Nomifensine; Probenecid

1977
Where are those new antidepressants we were promised?
    Archives of general psychiatry, 1988, Volume: 45, Issue:2

    Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Humans; Legislation, Drug; Mianserin; Nomifensine; Propiophenones; Selegiline; United States; United States Food and Drug Administration

1988

Other Studies

25 other study(ies) available for clomipramine and nomifensine

ArticleYear
3-aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:3

    Topics: Animals; Antidepressive Agents; Chemical Phenomena; Chemistry; Dopamine Agents; Female; Mice; Pyridazines; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship

1989
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Animals; Antidepressive Agents; Blepharoptosis; Brain; Catecholamines; Chemical Phenomena; Chemistry; Dopamine; Isoquinolines; Male; Molecular Conformation; Motor Activity; Norepinephrine; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Synaptosomes; Tetrabenazine

1987
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Species independence in brain tissue binding using brain homogenates.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Effect of nomifensine on brain amines and epilepsy in photosensitive baboons.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Amines; Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Imipramine; Isoquinolines; Maprotiline; Nomifensine; Papio; Photic Stimulation; Seizures

1977
Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Blood Platelets; Clomipramine; Dopamine; Female; Humans; In Vitro Techniques; Isoquinolines; Male; Nomifensine; Serotonin

1977
Different effects of serotonin (5-HT) uptake blockers in caudate nucleus and hippocampus of the rabbit: role of monoamine oxidase in dopaminergic terminals.
    Psychopharmacology, 1992, Volume: 106, Issue:1

    Topics: Acetylcholine; Animals; Caudate Nucleus; Clomipramine; Depression, Chemical; Dopamine; Female; Fluvoxamine; Hippocampus; In Vitro Techniques; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nerve Endings; Nomifensine; Pargyline; Pyridazines; Quipazine; Rabbits; Serotonin; Serotonin Antagonists

1992
Dopamine-mediated increases in nigral substance P-like immunoreactivity.
    Biochemical pharmacology, 1985, Sep-01, Volume: 34, Issue:17

    Topics: Animals; Citalopram; Clomipramine; Corpus Striatum; Dopamine; Male; Methamphetamine; Nalidixic Acid; Naphthyridines; Nomifensine; Propylamines; Radioimmunoassay; Rats; Rats, Inbred Strains; Reserpine; Serotonin; Substance P; Substantia Nigra

1985
Prenatal exposure of rats to antidepressant drugs down-regulates beta-adrenoceptors and 5-HT2 receptors in cerebral cortex. Lack of correlation between 5-HT2 receptors and serotonin-mediated behaviour.
    Neuropharmacology, 1985, Volume: 24, Issue:10

    Topics: Animals; Antidepressive Agents; Cerebral Cortex; Clomipramine; Female; Iprindole; Mianserin; Nomifensine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, Adrenergic, alpha; Receptors, Serotonin

1985
Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP.
    European journal of pharmacology, 1985, Oct-08, Volume: 116, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Clomipramine; Corpus Striatum; Desipramine; Dopamine; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Nomifensine; Norepinephrine; Pyridines; Serotonin Antagonists

1985
[Management of treatment-resistant depression without ECT (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1981, May-22, Volume: 106, Issue:21

    Topics: Antipsychotic Agents; Clomipramine; Depressive Disorder; Female; Humans; Male; Maprotiline; Nomifensine; Physical Therapy Modalities; Psychotherapy

1981
Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors?
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:3

    Topics: Acetylcholine; Animals; Clomipramine; Clonidine; Cocaine; Desipramine; Dopamine; Hemicholinium 3; In Vitro Techniques; Lysergic Acid Diethylamide; Male; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Nomifensine; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin; Synaptosomes

1984
Effect of antidepressant drugs on the in-vitro egg-penetrating ability of golden hamster epididymal spermatozoa.
    Journal of reproduction and fertility, 1983, Volume: 68, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Cricetinae; Desipramine; Female; Fertilization; Fertilization in Vitro; Male; Maleates; Mesocricetus; Mianserin; Nomifensine; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa; Viloxazine

1983
Activities of five antidepressants in a behavioral pain test in rats.
    Life sciences, 1983, Jun-27, Volume: 32, Issue:26

    Topics: Analgesia; Animals; Antidepressive Agents; Clomipramine; Desipramine; Electroshock; Male; Maprotiline; Nociceptors; Nomifensine; Rats; Rats, Inbred Strains; Viloxazine

1983
3H-mepyramine binding in various regions of rat brain following chronic treatment with different classes of antidepressant drugs.
    Progress in neuro-psychopharmacology & biological psychiatry, 1982, Volume: 6, Issue:4-6

    Topics: Aminopyridines; Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Female; Iprindole; Nomifensine; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Histamine H1

1982
[Pressor response to the stimulation of peripheral sympathetic nerves and the posterior hypothalamus in the presence of tricyclic antidepressive agents and nomifensine in dogs].
    Acta physiologica latino americana, 1982, Volume: 32, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Clomipramine; Dogs; Electric Stimulation; Hypothalamus; Hypothalamus, Posterior; Imipramine; Isoquinolines; Nomifensine; Peripheral Nerves

1982
[Effect of antidepressants on the secretion of pituitary hormones in healthy subjects, neurotic depressive patients and endogenous depressive patients (author's transl)].
    Der Nervenarzt, 1980, Volume: 51, Issue:12

    Topics: Adult; Anthracenes; Clomipramine; Depressive Disorder; Desipramine; Female; Growth Hormone; Humans; Isoquinolines; Luteinizing Hormone; Male; Maprotiline; Middle Aged; Nomifensine; Pituitary Hormones, Anterior; Prolactin; Thyrotropin

1980
Recovery of dopamine neuronal transporter but lack of change of its mRNA in substantia nigra after inactivation by a new irreversible inhibitor characterized in vitro and ex vivo in the rat.
    British journal of pharmacology, 1999, Volume: 128, Issue:1

    Topics: Animals; Binding, Competitive; Carrier Proteins; Choline; Clomipramine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Half-Life; In Vitro Techniques; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Nomifensine; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin; Substantia Nigra; Synaptosomes

1999
Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors.
    Synapse (New York, N.Y.), 2001, Sep-15, Volume: 41, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Animals; Benzazepines; Brain Chemistry; Clomipramine; Cocaine; Desipramine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; Male; Nomifensine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sulpiride

2001
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
    The Journal of biological chemistry, 2006, Jan-27, Volume: 281, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blotting, Western; Cadmium; Cell Line; Cell Membrane; Citalopram; Clomipramine; Cocaine; Cysteine; Dopamine Uptake Inhibitors; Fluoxetine; HeLa Cells; Humans; Immunoprecipitation; Isoleucine; Kinetics; LLC-PK1 Cells; Mazindol; Methionine; Mice; Models, Chemical; Molecular Sequence Data; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Nomifensine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Radiopharmaceuticals; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Species Specificity; Stereoisomerism; Substrate Specificity; Tyrosine

2006