clomipramine and desmethylclomipramine

clomipramine has been researched along with desmethylclomipramine in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (48.05)	18.7374
1990's	22 (28.57)	18.2507
2000's	10 (12.99)	29.6817
2010's	8 (10.39)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brøsen, K; Gram, LF; Nielsen, KK	1
Bertschy, G; Vandel, S	1
Advenier, C; Bastide, P; Bulach, C; Cordonnier, P; Duroux, E; Eschalier, A; Fialip, J; Marty, H; Pays, M; Varoquaux, O	1
Asberg, M; Beck, O; Brodin, K; Mårtensson, B; Montero, D; Wägner, A	1
Fujita, K; Kobayashi, A; Nakazawa, K; Suzuki, S	1
Gorecki, DK; Meldrum, LH; Remillard, AJ; Thakur, AK	1
Jones, B; Mavissakalian, M; Olson, S; Perel, JM	1
Balant, LP; Balant-Gorgia, AE; Gex-Fabry, M	1
Kupfer, DJ; Nathan, RS; Perel, JM; Pollock, BG	1
Bryan, W; Fraser, AD; Isner, AF	1
Eschalier, A; Fialip, J; Makambila, MC; Varoquaux, O	1
Bastide, P; Eschalier, A; Fialip, J; Makambila, MC; Marty, H; Varoquaux, O	1
Kido, H; Kishitani, K; Kurachi, M; Kurata, K; Yamaguchi, N	2
Christensen, P	1
Balant, L; Balant-Gorgia, AE; Zysset, T	1
Advenier, C; Morin, D; Pays, M; Spreux-Varoquaux, O	1
Alvarez, E; Casas, M; Garcia-Ribera, C; Grau, JM; Queralto, JM; Udina, C	1
Jungkunz, G; Kuss, HJ	1
Choisy, H; Denis, J; Havet, JM; Lamiable, D; Millart, H; Pascalis, G; Wargny, E	1
Ansseau, M; Geenen, V; Koinig, G; Langer, G; Legros, JJ; Schönbeck, G; Smitz, S; von Frenckell, R	1
Le Quan-Bui, KH; Lôo, H; Meyer, P; Poirier, MF	1
Devoize, JL; Eschalier, A; Fialip, J; Makambila, MC; Rigal, F; Varoquaux, O	1
Ericsson, O; Nordin, C; Spina, E	1
Benfield, DP; Harries, CM; Luscombe, DK	1
Ballerini, A; Broadhurst, AD; Das, M; Faravelli, C	1
Adamus, A; Górka, Z; Maj, J; Stala, L	1
Ambonetti, A; Ballerini, A; Broadhurst, AD; Das, M; Faravelli, C	1
Aronstam, RS; Narayanan, L	1
Della Corte, L; Sgaragli, GP	1
Itoh, M; Nakao, H; Notomi, A; Yufu, N	1
Cowe, L; Dawling, S; Lloyd, DJ	1
Burch, JE; Karajgi, B; Michalakeas, A; Raddats, MA; Roberts, SG; Shaw, DM	1
Cooper, TB; Friedman, E	1
Ambonetti, A; Ballerini, A; Broadhurst, AD; Das, M; De Biase, L; Faravelli, C; La Malfa, G	1
Aymard, N; Champiat, JC; des Lauriers, A	1
de Cuyper, HJ; de Zeeuw, RA; Mulder-Hajonides, WR; van Praag, HM; Westenberg, HG	1
Allers, G; Jounet, JM; Vandel, B; Vandel, S; Volmat, R	2
Colin, JN; Diquet, B; Gaudel, G; Singlas, E	1
Beckett, AH; Hutt, AJ; Navas, GE	1
Hullin, RP	1
Karobath, M; Lapin, A	1
Cioni, P; Della Corte, L; Giovannini, MG; Megazzini, I; Puliti, R; Sgaragli, GP; Wondrak, G	1
Foglia, JP; Perel, JM; Wisner, KL	1
Feet, PO; Götestam, KG	1
Dale, O; Hole, A	1
Bowler, KA; Kupfer, DJ; Miewald, JM; Perel, JM; Pollock, BG	1
Noguchi, T; Shimoda, K; Takahashi, S	1
Eriksson, E; Hedberg, MA; Sundblad, C	1
Fujita, K; Iijima, N; Nakazawa, K; Suzuki, S	1
Minowada, T; Noguchi, T; Shimoda, K; Takahashi, S	1
Härtter, S; Hiemke, C; Leal, M; Szegedi, A; Wetzel, H	1
Ballesta, J; de la Torre, R; González, S; Ortuño, J; Pascual, JA	1
Ball, RO; Conlon, PD; Hewson, CJ; Luescher, UA	1
da Motta Singer, J; Gorenstein, C; Marcourakis, T; Ramos, RT	1
Bertilsson, L; Böttiger, Y; Jerling, M; Morita, S; Shimoda, K; Yasuda, S	1
Bechtel, PR; Bizouard, P; Broly, F; Haffen, E; Sechter, D; Vandel, P; Vandel, S	1
Fisch, RD; Hotz, RP; King, JN; Maurer, MP	1
Altmann, BO; King, JN; Maurer, MP; Strehlau, GA	1
Armani, A; Biondi, L; Cassano, GB; Dell'Osso, L; Giannaccini, G; Lucacchini, A; Marazziti, D; Palego, L; Sarno, N	1
Bagli, M; Härtter, S; Hiemke, C; Weigmann, H	1
Balant, LP; Bechtel, PR; Bizouard, P; Gex-Fabry, M; Haffen, E; Paintaud, G; Sechter, D	1
Eto, S; Nakamura, J; Terao, T; Ueda, N; Yoshimura, R	1
Biondi, L; Cassano, GB; Ciapparelli, A; Dell'Osso, L; Giannaccini, G; Giromella, A; Marazziti, D; Palego, L; Sarno, N	1
DeVane, CL; Loughhead, AM; Newport, DJ; Owens, MJ; Ritchie, JC; Stowe, ZN	1
Doucet, M; Frank, D; Intorre, L; Lainesse, C; Meucci, V; Soldani, G	1
Aitchison, K; Datla, K; Dexter, D; Fernando, J; Rooprai, H	1
Bampton, ET; Bartesaghi, S; Bonanno, G; Dinsdale, D; Glynn, P; Guerra-Martin, MA; Knight, RA; Melino, G; Milanese, M; Munarriz, ER; Nicotera, P; Rossi, M	1
Farde, L; Gulyás, B; Halldin, C; Nag, S; Takano, A	1
Bernik, MA; Gedanke Shavitt, R; Gorenstein, C; Lotufo Neto, F; Marcourakis, T	1
Bongiorno-Borbone, L; Compagnone, M; De Maria, R; Eramo, A; Giacobbe, A; Melino, G; Peschiaroli, A	1
de Jong-van de Berg, LT; Proost, JH; Smit, JP; Ter Horst, PG; Vries, MT; Wilffert, B	1
Bishop, JR; Brown, JT; Eum, S; Schneiderhan, M	1
Dash, PK; Edagwa, B; Gelbard, H; Gendelman, HE; Gnanadhas, DP; Gorantla, S; Lin, Z; Machhi, J; McMillan, J; Thomas, MB	1
Ciszek, R; Ekolle Ndode-Ekane, X; Hämäläinen, E; Hiltunen, M; Hujo, M; Kansanen, E; Levonen, AL; Lipponen, A; Natunen, T; Paananen, J; Pitkänen, A; Poulsen, D; Tohka, J	1

Reviews

2 review(s) available for clomipramine and desmethylclomipramine

Article	Year
Compared plasma and brain pharmacokinetics of clomipramine and its metabolite demethylclomipramine in two strains of mice (NMRI and CD1). Fundamental & clinical pharmacology, 1992, Volume: 6, Issue:2 Topics: Animals; Clomipramine; Half-Life; Injections, Intraperitoneal; Male; Mice; Species Specificity; Tissue Distribution	1992
Serum clomipramine and desmethylclomipramine levels in a CYP2C19 and CYP2D6 intermediate metabolizer. Pharmacogenomics, 2017, Volume: 18, Issue:7 Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Depressive Disorder; Humans; Male; Obsessive-Compulsive Disorder; Retrospective Studies	2017

Trials

11 trial(s) available for clomipramine and desmethylclomipramine

Article	Year
Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group. European journal of clinical pharmacology, 1992, Volume: 43, Issue:4 Topics: Adult; Aged; Clomipramine; Cytochrome P-450 Enzyme System; Debrisoquin; Depression; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Sparteine	1992
Acute antidepressant effect following pulse loading with intravenous and oral clomipramine. Archives of general psychiatry, 1989, Volume: 46, Issue:1 Topics: Administration, Oral; Adult; Biological Availability; Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Personality Inventory; Psychiatric Status Rating Scales; Random Allocation	1989
Relationship between the plasma concentration of clomipramine and desmethylclomipramine in depressive patients and the clinical response. European journal of clinical pharmacology, 1982, Volume: 22, Issue:1 Topics: Adult; Aged; Biotransformation; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Time Factors	1982
Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine. Acta psychiatrica Scandinavica, 1994, Volume: 89, Issue:4 Topics: Adult; Ambulatory Care; Antipsychotic Agents; Clomipramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Panic Disorder; Phenothiazines; Placebos; Psychiatric Status Rating Scales; Stimulation, Chemical; Treatment Outcome	1994
Early response patterns associated with successful clomipramine treatment. Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:6 Topics: Adult; Clomipramine; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Humans; Male; Psychiatric Status Rating Scales	1993
Clomipramine administered during the luteal phase reduces the symptoms of premenstrual syndrome: a placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1993, Volume: 9, Issue:2 Topics: Adult; Affect; Appetite; Clomipramine; Dietary Carbohydrates; Edema; Female; Humans; Luteal Phase; Nipples; Premenstrual Syndrome	1993
Combination treatment with clomipramine and fluvoxamine: drug monitoring, safety, and tolerability data. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:6 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Electroencephalography; Female; Fluvoxamine; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors	1996
Serum levels of clomipramine and desmethylclomipramine and clinical improvement in panic disorder. Journal of psychopharmacology (Oxford, England), 1999, Volume: 13, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Female; Humans; Male; Middle Aged; Panic Disorder; Psychiatric Status Rating Scales; Single-Blind Method	1999
Clomipramine dose-effect study in patients with depression: clinical end points and pharmacokinetics. Danish University Antidepressant Group (DUAG). Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:2 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Clomipramine; Denmark; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Phenotype; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Sparteine; Treatment Outcome	1999
Pronounced differences in the dispositon of clomipramine between Japanese and Swedish patients. Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:5 Topics: Adolescent; Adult; Aged; Algorithms; Antidepressive Agents, Tricyclic; Biotransformation; Chromatography, High Pressure Liquid; Clomipramine; Female; Humans; Japan; Male; Middle Aged; Sweden	1999
Clomipramine demethylation rate is important on the outcome of obsessive-compulsive disorder treatment. International clinical psychopharmacology, 2015, Volume: 30, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Biotransformation; Brazil; Clomipramine; Dealkylation; Drug Monitoring; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Single-Blind Method; Treatment Outcome	2015

Other Studies

64 other study(ies) available for clomipramine and desmethylclomipramine

Article	Year
Clomipramine plasma levels among depressed outpatients in Benin, west Africa: drug compliance and comparison with Caucasian patients. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:5 Topics: Ambulatory Care; Benin; Black People; Clomipramine; Depressive Disorder; Humans; Patient Compliance; White People	1992
Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet 3H-imipramine binding and serotonin uptake and concentration in major depressive disorder. Acta psychiatrica Scandinavica, 1991, Volume: 83, Issue:2 Topics: Adult; Blood Platelets; Carrier Proteins; Clomipramine; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Neurotransmitter Agents; Psychiatric Status Rating Scales; Receptors, Drug; Receptors, Neurotransmitter; Receptors, Serotonin; Serotonin	1991
Changes of serotonin and catecholamines are related to pharmacokinetic alterations of clomipramine in rat brain. European journal of pharmacology, 1991, Nov-12, Volume: 204, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Clomipramine; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Time Factors; Tissue Distribution	1991
Intravenous clomipramine and obsessive-compulsive disorder. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:7 Topics: Clomipramine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Middle Aged; Obsessive-Compulsive Disorder	1991
The relationship of plasma clomipramine and N-desmethylclomipramine to response in obsessive-compulsive disorder. Psychopharmacology bulletin, 1990, Volume: 26, Issue:1 Topics: Adult; Clomipramine; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder	1990
Detection of populations at risk using drug monitoring data. Psychopharmacology series, 1989, Volume: 7 Topics: Adolescent; Aged; Biotransformation; Clomipramine; Dealkylation; Female; Humans; Hydroxylation; Male; Middle Aged; Risk Factors	1989
Evaluation of the EMIT amitriptyline and nortriptyline assays for the determination of serum clomipramine and desmethylclomipramine. Therapeutic drug monitoring, 1989, Volume: 11, Issue:3 Topics: Amitriptyline; Antibody Specificity; Clomipramine; Cross Reactions; Evaluation Studies as Topic; Humans; Immunoenzyme Techniques; Indicators and Reagents; Nortriptyline	1989
Study of the clomipramine-morphine interaction in the forced swimming test in mice. Psychopharmacology, 1987, Volume: 93, Issue:4 Topics: Animals; Antidepressive Agents; Clomipramine; Drug Interactions; Drug Tolerance; Male; Mice; Morphine; Physical Exertion; Swimming	1987
Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3 Topics: Analgesics; Animals; Clomipramine; Male; Mice; Motor Activity; Naloxone; Species Specificity	1988
A relationship between clomipramine brain concentration and its effect on serotonin metabolism. The Japanese journal of psychiatry and neurology, 1988, Volume: 42, Issue:1 Topics: Animals; Brain; Clomipramine; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin	1988
Receptor assay based on 3H-imipramine binding. Psychopharmacology series, 1987, Volume: 3 Topics: Antidepressive Agents; Binding, Competitive; Blood Platelets; Chromatography, Thin Layer; Citalopram; Clomipramine; Humans; Imipramine; Propylamines; Radioligand Assay	1987
High plasma concentrations of desmethylclomipramine after chronic administration of clomipramine to a poor metabolizer. European journal of clinical pharmacology, 1987, Volume: 32, Issue:1 Topics: Allopurinol; Clomipramine; Debrisoquin; Depressive Disorder; Female; Humans; Hydroxylation; Kinetics; Middle Aged	1987
A pharmacokinetic study of clomipramine in regions of the brain. The Japanese journal of psychiatry and neurology, 1986, Volume: 40, Issue:4 Topics: Animals; Blood-Brain Barrier; Brain; Clomipramine; Kinetics; Male; Rats; Rats, Inbred Strains	1986
Determination of clomipramine and its hydroxylated and demethylated metabolites in plasma and urine by liquid chromatography with electrochemical detection. Journal of chromatography, 1987, May-15, Volume: 416, Issue:2 Topics: Chromatography, High Pressure Liquid; Clomipramine; Drug Stability; Electrochemistry; Humans	1987
Myoclonic movements as a side-effect of treatment with therapeutic doses of clomipramine. International clinical psychopharmacology, 1987, Volume: 2, Issue:4 Topics: Adult; Aged; Clomipramine; Depression; Female; Humans; Male; Middle Aged; Myoclonus	1987
Nonlinear pharmacokinetics of chlorimipramine after infusion and oral administration in patients. Progress in neuro-psychopharmacology & biological psychiatry, 1986, Volume: 10, Issue:6 Topics: Administration, Oral; Affective Disorders, Psychotic; Clomipramine; Female; Humans; Infusions, Intravenous; Kinetics; Male	1986
[Plasma levels of clomipramine and declomipramine in patients with depression: a study of its correlation with therapeutic efficacy]. Annales medico-psychologiques, 1986, Volume: 144, Issue:4 Topics: Adolescent; Adult; Aged; Clomipramine; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Tranquilizing Agents	1986
Release of human neurophysin I during insulin-induced hypoglycemia in depressed patients is abolished after recovery with clomipramine treatment. Psychoneuroendocrinology, 1985, Volume: 10, Issue:1 Topics: Blood Glucose; Clomipramine; Depressive Disorder; Female; Humans; Insulin; Middle Aged; Neurophysins; Pituitary Gland, Posterior	1985
Changes in human platelet 5 HT level after 1 week of chlorimipramine treatment. Psychopharmacology, 1985, Volume: 86, Issue:1-2 Topics: Adult; Blood Platelets; Clomipramine; Female; Humans; Male; Middle Aged; Serotonin	1985
Chronic administration of clomipramine inhibits morphine hot plate analgesia. Life sciences, 1986, Mar-24, Volume: 38, Issue:12 Topics: Analgesia; Animals; Brain; Clomipramine; Hot Temperature; Mice; Morphine	1986
Analysis of tricyclic antidepressants in serum and plasma yields similar results. Therapeutic drug monitoring, 1985, Volume: 7, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dealkylation; Humans; Nortriptyline	1985
Some pharmacological aspects of desmethylclomipramine. Postgraduate medical journal, 1980, Volume: 56 Suppl 1 Topics: Clomipramine; Depression, Chemical; Gastrointestinal Motility; Hypothermia; Ileum; Neurotransmitter Agents; Receptors, Cholinergic; Reserpine; Synaptosomes	1980
Relevance of plasma levels during clomipramine treatment of primary depression. Journal of affective disorders, 1982, Volume: 4, Issue:2 Topics: Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Kinetics	1982
Comparison of the pharmacological actions of desmethylclomipramine and clomipramine. Psychopharmacology, 1982, Volume: 78, Issue:2 Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Blood Pressure; Brain Chemistry; Clomipramine; Hydroxydopamines; Male; Methamphetamine; Norepinephrine; Rats; Rats, Inbred Strains; Reserpine	1982
Plasma levels and clinical response during treatment with clomipramine. Journal of affective disorders, 1984, Volume: 6, Issue:1 Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Male; Middle Aged; Time Factors	1984
3-Chlorodibenzazepine binding to cholinergic receptors and ion channels. Research communications in chemical pathology and pharmacology, 1981, Volume: 34, Issue:3 Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Clomipramine; Electric Organ; Ion Channels; Kinetics; Rats; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Torpedo	1981
Tissue distribution of chlorimipramine and its demethylated metabolite after a single dose in the rat. Pharmacological research communications, 1984, Volume: 16, Issue:2 Topics: Animals; Clomipramine; Kidney; Lipid Metabolism; Liver; Lung; Male; Myocardium; Rats; Rats, Inbred Strains; Spleen; Tissue Distribution	1984
Simultaneous measurement of various antidepressants in the plasma of depressed patients by high performance liquid chromatography. Folia psychiatrica et neurologica japonica, 1984, Volume: 38, Issue:1 Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents; Chromatography, High Pressure Liquid; Clomipramine; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Maprotiline; Middle Aged; Nortriptyline	1984
Neonatal convulsions caused by withdrawal from maternal clomipramine. British medical journal (Clinical research ed.), 1982, Jun-19, Volume: 284, Issue:6332 Topics: Adult; Clomipramine; Depressive Disorder; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Pregnancy; Pregnancy Complications; Seizures; Substance Withdrawal Syndrome	1982
Time course of plasma drug levels during once-daily oral administration of clomipramine. Psychopharmacology, 1982, Volume: 77, Issue:4 Topics: Administration, Oral; Clomipramine; Humans; Time Factors	1982
Pharmacokinetics of chlorimipramine and its demethylated metabolite in blood and brain regions of rats treated acutely and chronically with chlorimipramine. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:2 Topics: Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Hypothalamus; Kinetics; Male; Rats; Rats, Inbred Strains; Septum Pellucidum; Subcellular Fractions	1983
Double-blind trial with oral versus intravenous clomipramine in primary depression. Biological psychiatry, 1983, Volume: 18, Issue:6 Topics: Administration, Oral; Clomipramine; Depressive Disorder; Double-Blind Method; Humans; Injections, Intravenous; Middle Aged	1983
[Plasma levels of desmethylclomipramine and clomipramine at steady-state in the morning. Correlative analysis and prediction of theoretical blood clomipramine]. L'Encephale, 1983, Volume: 9, Issue:1 Topics: Adult; Aged; Circadian Rhythm; Clomipramine; Depressive Disorder; Female; Humans; Hydrocortisone; Male; Middle Aged	1983
Pharmacokinetics of clomipramine in depressive patients. Psychiatry research, 1981, Volume: 4, Issue:2 Topics: Administration, Oral; Adult; Clomipramine; Depressive Disorder; Female; Humans; Injections, Intramuscular; Male; Middle Aged	1981
[Plasma assay of clomipramine and demethylclomipramine by high performance liquid chromatography]. Annales de biologie clinique, 1982, Volume: 40, Issue:4 Topics: Chromatography, High Pressure Liquid; Clomipramine; Humans; Microchemistry	1982
Metabolic oxidation of desmethylchlorimipramine in vitro by 9000 g rabbit-liver preparations. Xenobiotica; the fate of foreign compounds in biological systems, 1982, Volume: 12, Issue:10 Topics: Animals; Chromatography, Thin Layer; Clomipramine; Gas Chromatography-Mass Spectrometry; Hydroxylation; In Vitro Techniques; Liver; Male; Oxidation-Reduction; Rabbits	1982
Variation in plasma concentrations of clomipramine and desmethylclomipramine during clomipramine therapy. Postgraduate medical journal, 1980, Volume: 56 Suppl 1 Topics: Adolescent; Adult; Aged; Circadian Rhythm; Clomipramine; Depression; Female; Humans; Male; Middle Aged; Time Factors	1980
A sensitive and specific method for the determination of chlorimipramine and desmethylchlorimipramine in plasma using selected ion monitoring with chemical ionization. Biomedical mass spectrometry, 1980, Volume: 7, Issue:11-12 Topics: Antidepressive Agents, Tricyclic; Clomipramine; Depression; Gas Chromatography-Mass Spectrometry; Humans	1980
[Clomipramine and desmethylclomipramine: relationship between plasma levels and clinical effect (author's transl)]. L'Encephale, 1981, Volume: 7, Issue:5 Topics: Adjustment Disorders; Adult; Aged; Clomipramine; Depressive Disorder; Female; Humans; Kinetics; Male; Middle Aged	1981
[A GLC assay method for chlorimipramine and its NOR1 and NOR2 derivatives in plasma]. Bollettino della Societa italiana di biologia sperimentale, 1980, Dec-15, Volume: 56, Issue:23 Topics: Chromatography, Gas; Clomipramine; Humans	1980
Serum clomipramine and metabolite levels in four nursing mother-infant pairs. The Journal of clinical psychiatry, 1995, Volume: 56, Issue:1 Topics: Adult; Breast Feeding; Clomipramine; Female; Half-Life; Humans; Infant; Infant, Newborn; Male; Obsessive-Compulsive Disorder; Pregnancy; Pregnancy Complications	1995
Biphasic time-course of serum concentrations of clomipramine and desmethylclomipramine after a near-fatal overdose. Veterinary and human toxicology, 1994, Volume: 36, Issue:4 Topics: Adult; Chromatography, High Pressure Liquid; Clomipramine; Drug Overdose; Half-Life; Humans; Male	1994
Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data. Journal of affective disorders, 1993, Volume: 29, Issue:4 Topics: Adolescent; Adult; Aged; Biotransformation; Bipolar Disorder; Clomipramine; Depressive Disorder; Drug Monitoring; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Psychiatric Status Rating Scales; Structure-Activity Relationship; Treatment Outcome	1993
Effects of clonidine on desipramine- and desmethylclomipramine-induced 3-methoxy-4-hydroxyphenylglycol levels in rat brain. European journal of pharmacology, 1993, Oct-05, Volume: 242, Issue:3 Topics: Animals; Brain; Clomipramine; Clonidine; Desipramine; Drug Interactions; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Wistar	1993
Interindividual variations of desmethylation and hydroxylation of clomipramine in an Oriental psychiatric population. Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:3 Topics: Adolescent; Adult; Aged; Biotransformation; Clomipramine; Dose-Response Relationship, Drug; Ethnicity; Female; Humans; Japan; Male; Mental Disorders; Middle Aged	1993
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection. Therapeutic drug monitoring, 1998, Volume: 20, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Drug Monitoring; Humans; Imipramine; Linear Models; Nortriptyline; Promazine; Sensitivity and Specificity	1998
The pharmacokinetics of clomipramine and desmethylclomipramine in dogs: parameter estimates following a single oral dose and 28 consecutive daily oral doses of clomipramine. Journal of veterinary pharmacology and therapeutics, 1998, Volume: 21, Issue:3 Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Dog Diseases; Dogs; Gas Chromatography-Mass Spectrometry; Half-Life; Male; Mental Disorders	1998
Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype. Pharmacopsychiatry, 1999, Volume: 32, Issue:6 Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Clomipramine; Cytochrome P-450 CYP2D6; Drug Interactions; Drug Therapy, Combination; Female; Genotype; Humans; Obsessive-Compulsive Disorder; Phenotype	1999
Pharmacokinetics of clomipramine in dogs following single-dose intravenous and oral administration. American journal of veterinary research, 2000, Volume: 61, Issue:1 Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Biological Availability; Blood Proteins; Chromatography, Gas; Clomipramine; Cross-Over Studies; Dogs; Female; Injections, Intravenous; Male; Ultrafiltration	2000
Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration. American journal of veterinary research, 2000, Volume: 61, Issue:1 Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Area Under Curve; Chromatography, Gas; Clomipramine; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Male; Random Allocation; Sex Factors	2000
Simultaneous plasma level analysis of clomipramine, N-desmethylclomipramine, and fluvoxamine by reversed-phase liquid chromatography. Therapeutic drug monitoring, 2000, Volume: 22, Issue:2 Topics: Adult; Antidepressive Agents; Chromatography, High Pressure Liquid; Clomipramine; Female; Fluvoxamine; Humans; Male	2000
Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:5 Topics: Administration, Oral; Animals; Brain; Chromatography, High Pressure Liquid; Clomipramine; Half-Life; Kinetics; Male; Rats; Rats, Sprague-Dawley	2000
Population pharmacokinetics of clomipramine, desmethylclomipramine, and hydroxylated metabolites in patients with depression receiving chronic treatment: model evaluation. Therapeutic drug monitoring, 2000, Volume: 22, Issue:6 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Clomipramine; Computer Simulation; Depression; Drug Administration Schedule; Female; Humans; Hydroxylation; Male; Middle Aged; Models, Biological; Prospective Studies; Reproducibility of Results	2000
Delirious episodes induced by intravenous administration of clomipramine associated with an acute increase in its plasma concentrations. Psychiatry and clinical neurosciences, 2000, Volume: 54, Issue:6 Topics: Aged; Clomipramine; Delirium; Depressive Disorder; Female; Humans; Injections, Intravenous; Middle Aged	2000
Simultaneous analysis of clozapine, clomipramine and their metabolites by reversed-phase liquid chromatography. Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:3 Topics: Antidepressive Agents, Tricyclic; Chromatography, Liquid; Clomipramine; Clozapine; Female; Humans; Least-Squares Analysis; Linear Models; Male	2001
Placental passage of tricyclic antidepressants. Biological psychiatry, 2006, Feb-01, Volume: 59, Issue:3 Topics: Antidepressive Agents, Tricyclic; Birth Weight; Clomipramine; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Nortriptyline; Pregnancy; Pregnancy Complications	2006
Pharmacokinetics of clomipramine and desmethylclomipramine after single-dose intravenous and oral administrations in cats. Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:4 Topics: Administration, Oral; Animals; Area Under Curve; Cats; Chromatography, High Pressure Liquid; Clomipramine; Cross-Over Studies; Female; Injections, Intravenous; Ovariectomy; Selective Serotonin Reuptake Inhibitors	2006
Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration. Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:8 Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Distribution	2010
Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux. Journal of cell science, 2009, Sep-15, Volume: 122, Issue:Pt 18 Topics: Animals; Autophagy; Biomarkers; Clomipramine; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Doxorubicin; Green Fluorescent Proteins; HeLa Cells; Humans; Mice; Microtubule-Associated Proteins; Phagosomes; Point Mutation; Recombinant Fusion Proteins; Time Factors	2009
NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo. Psychopharmacology, 2011, Volume: 216, Issue:2 Topics: Animals; Antidepressive Agents, Tricyclic; Clomipramine; Dose-Response Relationship, Drug; Macaca fascicularis; Male; Morpholines; Norepinephrine Plasma Membrane Transport Proteins; Positron-Emission Tomography; Protein Binding	2011
Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells. Oncotarget, 2015, Jul-10, Volume: 6, Issue:19 Topics: Adenocarcinoma; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Clomipramine; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Neoplastic Stem Cells; Repressor Proteins; RNA Interference; Ubiquitin-Protein Ligases	2015
Pharmacokinetics of clomipramine during pregnancy. European journal of clinical pharmacology, 2015, Volume: 71, Issue:12 Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Clomipramine; Depression; Female; Humans; Pregnancy; Pregnancy Complications; Psychiatric Status Rating Scales; Severity of Illness Index; Tandem Mass Spectrometry	2015
Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine (London, England), 2018, Volume: 13, Issue:17 Topics: Anti-HIV Agents; Atazanavir Sulfate; Autophagy; beta-Cyclodextrins; Cell Survival; Clomipramine; Clonidine; Drug Carriers; Drug Interactions; Drug Liberation; HIV-1; Humans; Macrophages; Metformin; Nanoparticles; Particle Size; Pyridines; Pyrroles; Sirolimus; Tissue Distribution	2018
In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. International journal of molecular sciences, 2019, Oct-29, Volume: 20, Issue:21 Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Brain Injuries, Traumatic; Cell Line; Clomipramine; Coculture Techniques; Cytokines; Disease; Gene Expression; In Vitro Techniques; Ionomycin; Machine Learning; Male; Microglia; Neurons; Neuroprotection; Neuroprotective Agents; NF-E2-Related Factor 2; Nitrites; Rats; Sirolimus; Systems Biology; Transcriptome; Trimipramine; Tumor Necrosis Factor-alpha; Up-Regulation	2019