clofilium and ly 97241

clofilium has been researched along with ly 97241 in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's4 (57.14)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gessner, G; Heinemann, SH1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD1
Sen, S; Sinha, N1
Arena, JP; Kass, RS1
Busch, AE; Heinemann, SH; Lang, F; Schönherr, R; Suessbrich, H1
Steidl, JV; Yool, AJ1
Finlayson, K; January, CT; Kelly, JS; Sharkey, J; Turnbull, L1

Other Studies

7 other study(ies) available for clofilium and ly 97241

ArticleYear
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.
    British journal of pharmacology, 2003, Volume: 138, Issue:1

    Topics: Animals; Cell Line; Cricetinae; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Humans; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Xenopus

2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2004
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked.
    Molecular pharmacology, 1988, Volume: 34, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Female; Guinea Pigs; Heart; Ion Channels; Male; Potassium; Quaternary Ammonium Compounds; Structure-Activity Relationship; Time Factors

1988
Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241.
    FEBS letters, 1997, Sep-08, Volume: 414, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Cation Transport Proteins; Cloning, Molecular; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Humans; Kinetics; Membrane Potentials; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Recombinant Proteins; Shal Potassium Channels; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG; Xenopus laevis

1997
Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds.
    Biophysical journal, 2001, Volume: 81, Issue:5

    Topics: Animals; Female; Hydrogen-Ion Concentration; Kv1.5 Potassium Channel; Membrane Potentials; Oocytes; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Rats; Recovery of Function; Time Factors; Xenopus laevis

2001
[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
    European journal of pharmacology, 2001, Oct-26, Volume: 430, Issue:1

    Topics: Anti-Arrhythmia Agents; Benzimidazoles; Binding, Competitive; Cation Transport Proteins; Cell Line; Cell Membrane; DNA-Binding Proteins; Drug Evaluation, Preclinical; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Haloperidol; Humans; Patch-Clamp Techniques; Phenethylamines; Pimozide; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Sulfanilamides; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tritium

2001