clofibric acid has been researched along with phenobarbital in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (29.03) | 18.7374 |
| 1990's | 17 (54.84) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Gógl, A; Klinger, W; Müller, D; Ruzsa, C; Simon, K; Vezekényi, Z | 1 |
| Lindroos, P; Michalopoulos, GK; Tsai, WH; Zarnegar, R | 1 |
| Fox, TR; Maher, VM; McCormick, JJ; Schumann, AM; Watanabe, PG; Yano, BL | 1 |
| Cruise, JL; Michalopoulos, GK; Tsai, WH | 1 |
| Bars, RG; Elcombe, CR; Mitchell, AM; Wolf, CR | 1 |
| Clark, TD; Glauert, HP | 1 |
| Brooks, B; Brown, P; Byers, LW; Capdevila, J; Dowell, R; Muirhead, E; Pitcock, JA | 1 |
| Estabrook, RW; Weiss, RH | 1 |
| Dobbs, BR; Faed, EM; Lee, D | 1 |
| Bock, KW; Lilienblum, W; Walli, AK | 1 |
| Baldwin, JR; Feller, DR; Witiak, DT | 1 |
| Knights, KM; Roberts, BJ | 1 |
| Castell, JV; Donato, MT; Gómez-Lechón, MJ | 1 |
| Ioannides, C; Irizar, A | 1 |
| Lindroos, P; Michalopoulos, GK | 1 |
| Chen, ZY; Eaton, DL; He, CY; Liu, YF; White, CC | 2 |
| Cattley, RC; Glover, SE | 1 |
| Blain, PG; McCracken, NW; Williams, FM | 1 |
| Guzelian, PS; Kocarek, TA; Schuetz, EG | 1 |
| Franklin, MR; Moody, DE; Slawson, MH | 1 |
| Beamand, JA; Charzat, C; Lake, BG; Price, RJ; Renwick, AB; Tredger, JM | 1 |
| Glauert, HP; Hong, JT; Wilson, MW | 1 |
| Glauert, HP; Leung, LK | 1 |
| Carroll, K; DeHaan, R; LeCluyse, E; Madan, A; Mudra, D; Parkinson, A | 1 |
| Novak, RF; Woodcroft, KJ | 1 |
| Davies, DS; Edwards, RJ; Neubert, D; Schulz, TG; Thier, R; Wiebel, FA | 1 |
| Bigot-Lasserre, D; Carmichael, N; Nicod, L; Richert, L; Viollon-Abadie, C | 1 |
| Brouwer, KL; Chandra, P; Johnson, BM; Pollack, GM; Zhang, P | 1 |
| Ahmed, MM; El-Shazly, SA; Fujita, S; Ibrahim, ZS; Ishizuka, M | 1 |
1 review(s) available for clofibric acid and phenobarbital
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
30 other study(ies) available for clofibric acid and phenobarbital
| Article | Year |
|---|---|
Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat.
Topics: Adolescent; Adult; Animals; Chemical Phenomena; Chemistry; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gilbert Disease; Humans; Liver; Male; Microsomes, Liver; Middle Aged; Organ Size; Phenobarbital; Rats; Sleep | 1979 |
Plasma levels of HGF in rats treated with tumor promoters.
Topics: Animals; Carcinogens; Clofibric Acid; Fibric Acids; Growth Substances; Hepatocyte Growth Factor; Hexachlorocyclohexane; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
Topics: Animals; Base Sequence; Benzidines; Chloroform; Clofibric Acid; Codon; DNA Mutational Analysis; DNA, Neoplasm; Fibric Acids; Gene Amplification; Genes, ras; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phenobarbital | 1990 |
Blockade of alpha-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters.
Topics: Animals; Carcinogens; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Hexachlorocyclohexane; Liver; Organ Size; Phenobarbital; Prazosin; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha | 1989 |
Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Isoenzymes; Isomerism; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1989 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Female; Fibric Acids; Liver; Liver Neoplasms, Experimental; Microbodies; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Effect of cytochrome P-450 induction and inhibition on the antihypertensive function of the kidney.
Topics: Animals; Blood Pressure; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Hypertension, Renovascular; Hypertrophy; Hypolipidemic Agents; Liver; Male; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Reference Values | 1987 |
The mechanism of cumene hydroperoxide-dependent lipid peroxidation: the function of cytochrome P-450.
Topics: Animals; Benzene Derivatives; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanol; Fibric Acids; Heme; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipid Peroxides; Male; Microsomes, Liver; Oxygen; Phenobarbital; Rats; Substrate Specificity | 1986 |
Glucuronidation and elimination of diflunisal in the isolated perfused rat liver: effect of pretreatment with phenobarbitone, clofibric acid and spironolactone.
Topics: Animals; Bile; Biotransformation; Clofibric Acid; Diflunisal; Glucuronates; In Vitro Techniques; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Salicylates; Spironolactone | 1984 |
Differential induction of rat liver microsomal UDP-glucuronosyltransferase activites by various inducing agents.
Topics: Animals; Aroclors; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofibric Acid; DDT; Enzyme Induction; Glucuronosyltransferase; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes | 1982 |
Disposition of clofibrate in the rat. Acute and chronic administration.
Topics: Animals; Bile; Cholesterol; Cholestyramine Resin; Clofibrate; Clofibric Acid; Ethylmorphine; Feces; Male; Microsomes, Liver; Phenobarbital; Rats; Subcellular Fractions; Tissue Distribution; Triglycerides | 1980 |
Differential induction of rat hepatic microsomal and peroxisomal long-chain and nafenopin-CoA ligases by clofibric acid and di-(2-ethylhexyl)phthalate.
Topics: Acyl Coenzyme A; Animals; Clofibric Acid; Coenzyme A Ligases; Diethylhexyl Phthalate; In Vitro Techniques; Male; Microbodies; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins | 1995 |
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone | 1995 |
Expression and inducibility of cytochrome P450 proteins belonging to families 2,3 and 4 in the rabbit aorta.
Topics: Animals; Aorta; Arteriosclerosis; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Male; Microsomes; Phenobarbital; Pregnenolone Carbonitrile; Rabbits | 1995 |
Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels.
Topics: Animals; Cell Division; Cells, Cultured; Clofibric Acid; Collagen; DNA; Drug Interactions; Epidermal Growth Factor; Fibric Acids; Fibroblast Growth Factor 1; Hepatocyte Growth Factor; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1993 |
Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules.
Topics: Animals; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; DNA; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transferase; Hyperplasia; Liver; Mice; Phenobarbital; Rats; Rats, Inbred F344 | 1994 |
Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization.
Topics: Animals; Body Weight; Carcinogens; Cell Nucleus; Clofibric Acid; Diethylhexyl Phthalate; DNA; Guanosine; Liver; Male; Microbodies; Organ Size; Phenobarbital; Pyrimidines; Rats; Rats, Inbred F344 | 1993 |
Peripheral esterases in the rat: effects of classical inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Enzyme Induction; Esterases; Herbicides; Hydrolysis; Inactivation, Metabolic; Liver; Lung; Male; Paraoxon; Phenobarbital; Phenylacetates; Pyridines; Rats; Rats, Wistar; Skin | 1993 |
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Fibric Acids; Hydroxycholesterols; Hypolipidemic Agents; L-Lactate Dehydrogenase; Liver; Lovastatin; Male; Mevalonic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxide Hydrolases; Ethanol; Glucuronosyltransferase; Glutathione Transferase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Safrole | 1996 |
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Humans; Isoenzymes; Liver; Male; Microbodies; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley | 1996 |
Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes.
Topics: Animals; Biomarkers, Tumor; Cells, Cultured; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Hypolipidemic Agents; Leukotriene C4; Liver; Male; Microbodies; Phenobarbital; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1995 |
Lack of correlation between hepatic prostaglandin concentrations and DNA synthesis after the administration of phenobarbital and the peroxisome proliferator ciprofibrate in rats.
Topics: Acyl-CoA Oxidase; Animals; Carcinogens; Clofibric Acid; Cytochrome P-450 CYP2B1; Dinoprost; Dinoprostone; DNA; Fibric Acids; Liver; Male; Microbodies; Microsomes, Liver; Oxidoreductases; Phenobarbital; Prostaglandins; Rats; Rats, Sprague-Dawley | 1997 |
Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens.
Topics: Animals; Blotting, Northern; Bromodeoxyuridine; Carcinogens; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; DNA; Fibric Acids; Gene Expression Regulation, Enzymologic; Liver; Male; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; RNA, Messenger | 1995 |
Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cryopreservation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1999 |
Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Cells, Cultured; Clofibric Acid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Insulin; Liver; Male; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Xenobiotics | 1999 |
Identification of theta-class glutathione S-transferase in liver cytosol of the marmoset monkey.
Topics: Animals; Callithrix; Chromatography, Affinity; Clofibric Acid; Cytosol; Dinitrochlorobenzene; Epoxy Compounds; Glutathione Transferase; Humans; Liver; Methyl Chloride; Methylene Chloride; Mice; Mice, Inbred BALB C; Nitrophenols; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Wistar; Rifampin; Species Specificity | 2000 |
Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures.
Topics: Animals; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Enzyme Induction; Glucuronosyltransferase; Hepatocytes; Male; Mice; Mice, Inbred Strains; Monosaccharide Transport Proteins; Phenobarbital; Rats; Rats, Sprague-Dawley | 2000 |
Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile Canaliculi; Clofibric Acid; Dexamethasone; Fluoresceins; Fluorescent Dyes; Hepatocytes; Infusions, Intravenous; Liver; Male; Organic Anion Transporters, Sodium-Independent; Perfusion; Phenobarbital; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2005 |
Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clofibric Acid; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B1; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Humans; Insulin; Liver; Mice; Phenobarbital; PPAR alpha; Pyridines; Rats; Receptors, Cytoplasmic and Nuclear; Steroid Hydroxylases | 2014 |