clofibric acid and fenofibric acid

clofibric acid has been researched along with fenofibric acid in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's10 (41.67)18.2507
2000's6 (25.00)29.6817
2010's2 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brown, PJ; Chapman, JM; Kliewer, SA; Koble, CS; Lehmann, JM; Lewis, MC; Moore, LB; Plunket, KD; Sundseth, SS; Willson, TM; Wilson, JG; Winegar, DA; Wu, Z1
Beneton, V; Boullay, AB; Boyer, T; Brewster, AG; Donche, F; Forest, MC; Fouchet, MH; Gellibert, FJ; Grillot, DA; Lambert, MH; Laroze, A; Le Grumelec, C; Linget, JM; Montana, VG; Nguyen, VL; Nicodème, E; Patel, V; Penfornis, A; Pianetti, PM; Pineau, O; Pohin, D; Potvain, F; Poulain, G; Ruault, CB; Saunders, M; Sierra, ML; Toum, J; Xu, HE; Xu, RX1
Conte Camerino, D; Fracchiolla, G; Laghezza, A; Lavecchia, A; Loiodice, F; Mazza, F; Montanari, R; Novellino, E; Piemontese, L; Pierno, S; Pochetti, G; Tortorella, P1
Brinkjost, T; Ehrt, C; Koch, O1
Aarsland, A; Berge, RK1
Galteau, MM; Guéguen, R; Leroy, P; Liu, HF; Magdalou, J; Nicolas, A; Siest, G; Vincent-Viry, M1
Fournel, S; Magdalou, J; Pinon, P; Siest, G1
Beaumont, JL; Beaumont, V; Buxtorf, JC; Carcone, B; Doucet, F; Edouard, L; Jacotot, B1
Bakir, R; Chanu, B; Djian, F; Goy-Loeper, J; Rouffy, J1
Franceschini, G; Paoletti, R; Sirtori, CR1
Santafé Oroz, J; Segarra Domènech, J1
Lehmann-Leo, W; Luley, C; Scheffler, W; Schilling, A; Schwartzkopff, W; Wegscheider, K1
Cornu-Chagnon, MC; Dupont, H; Edgar, A1
Caldwell, J; Grubb, N; Weil, A1
Walsh, KB; Wang, C1
Cuniberti, LA; Masnatta, LD; Rey, RH; Werba, JP1
Kockx, M; Kooistra, T; Princen, HM1
Derudas, B; Gervois, PP; Gonzalez, FJ; Kockx, M; Kooistra, T; Peters, JM; Poulain, P; Princen, HM; Staels, B1
Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T1
Mikhailidis, DP; Wierzbicki, AS; Wray, R1
Cariou, B; Costet, P; Jarnoux, AL; Kourimate, S; Krempf, M; Langhi, C; Le May, C; Nguyen, P; Ouguerram, K; Zaïr, Y1
Jacobson, TA1
Chalmers, DK; Chuang, S; Horne, J; Porter, CJ; Scanlon, MJ; Velkov, T; Wielens, J1
Fukuhara, H; Hoshina, M; Karahashi, M; Kawashima, Y; Kudo, N; Mitsumoto, A; Sakamoto, T; Yamazaki, T1

Reviews

3 review(s) available for clofibric acid and fenofibric acid

ArticleYear
[Pharmacologic therapy of atherosclerosis (I). Current possibilities].
    Medicina clinica, 1983, Nov-26, Volume: 81, Issue:17

    Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Clofibrate; Clofibric Acid; Fenofibrate; Gemfibrozil; Glycosaminoglycans; Humans; Ion Exchange Resins; Lipoproteins; Nicotinic Acids; Pentanoic Acids; Probucol

1983
Drug treatment of combined hyperlipidemia.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2001, Volume: 1, Issue:5

    Topics: Acute Disease; Clofibric Acid; Diabetes Mellitus, Type 2; Female; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Insulin Resistance; Liver Diseases; Obesity; Pancreatitis; Pregnancy; Pregnancy Complications

2001
Myopathy with statin-fibrate combination therapy: clinical considerations.
    Nature reviews. Endocrinology, 2009, Volume: 5, Issue:9

    Topics: Clofibric Acid; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents

2009

Trials

4 trial(s) available for clofibric acid and fenofibric acid

ArticleYear
Effects of several lipid-lowering drugs on skin total and esterified cholesterol.
    Monographs on atherosclerosis, 1986, Volume: 14

    Topics: Cholesterol Esters; Clinical Trials as Topic; Clofibric Acid; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Probucol; Random Allocation; Skin

1986
Comparative evaluation of the effects of ciprofibrate and fenofibrate on lipids, lipoproteins and apoproteins A and B.
    Atherosclerosis, 1985, Volume: 54, Issue:3

    Topics: Adult; Apolipoproteins A; Apolipoproteins B; Clofibrate; Clofibric Acid; Drug Evaluation; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Male; Propionates; Time Factors

1985
Influence of bezafibrate, fenofibrate, nicotinic acid and etofibrate on plasma high-density lipoprotein levels.
    The American journal of cardiology, 1983, Aug-22, Volume: 52, Issue:4

    Topics: Adipose Tissue; Animals; Apolipoprotein C-II; Apolipoprotein C-III; Apolipoproteins; Apolipoproteins C; Bezafibrate; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Clofibric Acid; Fenofibrate; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipolysis; Lipoproteins, HDL; Niacin; Rats; Structure-Activity Relationship

1983
[Efficacy of bezafibrate and fenofibrate on elevated blood lipids in HLP type IIa, IIb and IV].
    Die Medizinische Welt, 1982, Apr-30, Volume: 33, Issue:17

    Topics: Adult; Aged; Anticholesteremic Agents; Bezafibrate; Clofibrate; Clofibric Acid; Female; Fenofibrate; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipids; Male; Middle Aged; Propionates

1982

Other Studies

17 other study(ies) available for clofibric acid and fenofibric acid

ArticleYear
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
    Journal of medicinal chemistry, 1999, Sep-23, Volume: 42, Issue:19

    Topics: Animals; Butyrates; DNA-Binding Proteins; Fenofibrate; Humans; Hypolipidemic Agents; Lipid Metabolism; Male; Mice; Nuclear Proteins; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Zinc Fingers

1999
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Animals; Apolipoprotein A-I; Cholesterol, HDL; Cholesterol, VLDL; Crystallography, X-Ray; Dogs; Dyslipidemias; Humans; Ligands; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Molecular; PPAR alpha; Propionates; Protein Structure, Tertiary; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles; Triglycerides

2007
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
    Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20

    Topics: Animals; Cell Line, Tumor; Chloride Channels; Chlorides; Clofibric Acid; Crystallography, X-Ray; Drug Discovery; Electric Conductivity; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligands; Male; Models, Molecular; Molecular Conformation; Muscle, Skeletal; Muscular Diseases; PPAR alpha; PPAR gamma; Propionates; Rats; Rats, Wistar; Rest; Stereoisomerism; Substrate Specificity

2009
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design.
    Journal of medicinal chemistry, 2016, 05-12, Volume: 59, Issue:9

    Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Models, Chemical; Proteins

2016
Peroxisome proliferating sulphur- and oxy-substituted fatty acid analogues are activated to acyl coenzyme A thioesters.
    Biochemical pharmacology, 1991, Jan-01, Volume: 41, Issue:1

    Topics: Animals; Clofibric Acid; Enzyme Activation; Fatty Acids; Fenofibrate; Liver; Male; Microbodies; Oxides; Palmitoyl Coenzyme A; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Sulfides; Sulfoxides

1991
Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:2

    Topics: Adult; Chromatography, High Pressure Liquid; Clofibric Acid; Female; Fenofibrate; Glucuronates; Humans; Hypolipidemic Agents; Male; Middle Aged; Molecular Structure; Polymorphism, Genetic; Reference Values

1991
Differential induction profile of drug-metabolizing enzymes after treatment with hypolipidaemic agents.
    Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:4

    Topics: Animals; Biphenyl Compounds; Body Weight; Butyrophenones; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Fenofibrate; gamma-Glutamyltransferase; Glucuronosyltransferase; Hypolipidemic Agents; Lipids; Liver; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1987
Fenofibrate: metabolism and species differences for peroxisome proliferation in cultured hepatocytes.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 26, Issue:1

    Topics: Animals; Cells, Cultured; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fenofibrate; Fibric Acids; Guinea Pigs; Humans; Liver; Male; Mass Spectrometry; Microbodies; Mixed Function Oxygenases; Palmitoyl Coenzyme A; Rats; Rats, Wistar; Species Specificity; Time Factors; Tumor Cells, Cultured

1995
Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism.
    Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

    Topics: Buffers; Clofibric Acid; Fenofibrate; Glucuronates; Humans; In Vitro Techniques; Protein Binding; Serum Albumin; Solutions

1993
Effect of chloride channel blockers on the cardiac CFTR chloride and L-type calcium currents.
    Cardiovascular research, 1996, Volume: 32, Issue:2

    Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Chloride Channels; Chlorides; Clofibric Acid; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Fenofibrate; Gemfibrozil; Glycolates; Guinea Pigs; Ion Transport; Mice; Myocardium; ortho-Aminobenzoates; Patch-Clamp Techniques; Stilbenes

1996
Determination of bezafibrate, ciprofibrate and fenofibric acid in human plasma by high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical applications, 1996, Dec-13, Volume: 687, Issue:2

    Topics: Bezafibrate; Calibration; Chromatography, High Pressure Liquid; Clofibric Acid; Fenofibrate; Fibric Acids; Humans; Hypolipidemic Agents; Reproducibility of Results; Sensitivity and Specificity

1996
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
    Thrombosis and haemostasis, 1998, Volume: 80, Issue:6

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin

1998
Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.
    Blood, 1999, May-01, Volume: 93, Issue:9

    Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; DNA-Binding Proteins; Fenofibrate; Fibric Acids; Fibrinogen; Gene Expression Regulation; Hypolipidemic Agents; Kinetics; Liver; Male; Mice; Mice, Knockout; Peroxisome Proliferators; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transcription, Genetic; Triglycerides

1999
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:6

    Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic

1999
Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
    The Journal of biological chemistry, 2008, Apr-11, Volume: 283, Issue:15

    Topics: Anticholesteremic Agents; Cell Line, Tumor; Clofibric Acid; DNA-Binding Proteins; Fenofibrate; Furin; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Hydrocarbons, Fluorinated; Hyperlipoproteinemia Type II; Lipid Metabolism; Liver X Receptors; Orphan Nuclear Receptors; PPAR alpha; Pravastatin; Promoter Regions, Genetic; Proprotein Convertase 5; Proprotein Convertase 9; Proprotein Convertases; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Serine Endopeptidases; Sulfonamides; Up-Regulation

2008
Probing the fibrate binding specificity of rat liver fatty acid binding protein.
    Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17

    Topics: Animals; Binding Sites; Carboxylic Acids; Clofibric Acid; Esters; Fatty Acid-Binding Proteins; Fenofibrate; Hypolipidemic Agents; Ligands; Liver; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Rats; Spectrometry, Fluorescence; Substrate Specificity; Temperature; Thermodynamics

2009
A simple and sensitive method for the determination of fibric acids in the liver by liquid chromatography.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:1

    Topics: Acyl-CoA Oxidase; Animals; Bezafibrate; Chromatography, High Pressure Liquid; Clofibric Acid; Fenofibrate; Fibric Acids; Liver; Male; PPAR alpha; Rats; Rats, Wistar; Reproducibility of Results; RNA, Messenger

2014