clofibric acid has been researched along with clofibrate in 299 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 249 (83.28) | 18.7374 |
| 1990's | 36 (12.04) | 18.2507 |
| 2000's | 12 (4.01) | 29.6817 |
| 2010's | 2 (0.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Bleve, L; Colabufo, NA; Jockers, R; Milazzo, FM; Perrone, MG; Santandrea, E; Sciarroni, AF; Scilimati, A; Vitale, P | 1 |
| Alaniz-Palacios, A; Ávila-Villarreal, G; Estrada-Soto, S; González-Acevedo, C; Guerrero-Álvarez, J; Hidalgo-Figueroa, S; López-Vallejo, F; Medina-Franco, JL; Navarrete-Vázquez, G; Tlahuext, H; Webster, SP | 1 |
| Aragones, MD; Armijo, M; Catalán, RE; Martinez, AM; Priego, JG | 1 |
| Falkensammer, C; Fischer, M | 1 |
| Catalan, RE; Maroto, ML; Piña, M; Priego, JG | 2 |
| Laker, ME; Mayes, PA | 1 |
| Gógl, A; Klinger, W; Müller, D; Ruzsa, C; Simon, K; Vezekényi, Z | 1 |
| Caldwell, J; Emudianughe, TS; Smith, RL | 1 |
| Gustafson, A | 1 |
| Kapoor, A; Veronich, K; White, G | 1 |
| Arnold, A; Beyler, AL; McAuliff, MP | 1 |
| Loewer, H; Mertz, DP; Suermann, I | 1 |
| Bolzano, K; Krempler, F; Schellenberg, B; Schlierf, G | 1 |
| Magnet, K; Paltauf, F | 1 |
| Bolzano, K; Haslauer, F; Krempler, F | 1 |
| Pfeiffer, M; Tilsner, V | 1 |
| Bruseghini, L; Vilageliu, J | 1 |
| Rahlfs, VW; Safer, A; Zimmermann, H | 1 |
| Baldwin, LA; Calabrese, EJ; Leonard, DA; Ochs, JB | 1 |
| Keller, BJ; Thurman, RG; Yamanaka, H | 1 |
| Gibson, GG; Lake, BG | 1 |
| Gemmell, MA; Giometti, CS; Lalwani, ND; Reddy, JK; Taylor, J; Tollaksen, SL | 1 |
| Eacho, PI; Foxworthy, PS; Hoover, DM; White, SL | 1 |
| Beaty, MM; Borges, T; Chen, LC; Chow, CK; Clark, TD; Clark, TL; Glauert, HP; Greenwell, WS; Srinivasan, SR; Tatum, V | 1 |
| Beije, B; Erixon, K; Nilsson, R; Préat, V; Ramel, C | 1 |
| Kłosiewicz-Latoszek, L; Szostak, WB | 1 |
| Kawashima, Y; Kozuka, H; Musoh, K | 1 |
| Cherkaoui Malki, M; Corral-Debrinski, M; Latruffe, N; Lone, YC | 1 |
| Bardot, O; Cherkaoui Malki, M; Latruffe, N; Lhuguenot, JC | 1 |
| Bronfman, M; Hidalgo, PC; Mezzano, D; Morales, MN; Orellana, A | 1 |
| Betz, E; Quack, G | 1 |
| Blaauboer, BJ; Bleumink, R; Mennes, WC; Schmid, BP; Timmerman, A; van Holsteijn, CW; van Iersel, AA; van Pelt, FN; van Pelt, JF; Yap, SH | 1 |
| Baldwin, LA; Calabrese, EJ; Kostecki, PT; Yang, JH | 1 |
| Chow, CK; Glauert, HP; Srinivasan, SR | 1 |
| Anders, C; Bonner, F; Gibson, GG; Goldfarb, PS; Makowska, JM | 1 |
| Esbenshade, TA; Feller, DR; Kamanna, VS; Newman, HA; Tortorella, V; Witiak, DT | 1 |
| Bartles, JR; Fayos, BE; Isoye, ST; Khuon, S; Lin, XH; Nehme, CL; Rao, MS; Reddy, JK; Zhang, LQ | 1 |
| Bettoni, G; Bryant, SH; Conte-Camerino, D; Feller, DR; Kamanna, VS; Loiodice, F; Newman, HA; Romstedt, KJ; Tortorella, V; Witiak, DT | 1 |
| Bettoni, G; Bryant, SH; Conte-Camerino, D; Ferrannini, E; Loiodice, F; Mambrini, M; Tortorella, V | 1 |
| Cruise, JL; Michalopoulos, GK; Tsai, WH | 1 |
| Bettoni, G; Bryant, SH; Conte Camerino, D; De Luca, A; Grasso, G; Mambrini, M; Tortorella, V; Tricarico, D | 1 |
| Bettoni, G; Bryant, SH; Conte-Camerino, D; DeLuca, A; Mambrini, M; Tortorella, V; Tricarico, D | 1 |
| Barbolt, TA; Bonner, FW; Eason, CT; Henry, DC; Sauerschell, RJ; Spencer, AJ | 1 |
| Feller, DR; Kim, SU; Newman, HA; Romstedt, KJ; Witiak, DT | 1 |
| Cleary, MP; Mohan, PF | 1 |
| Rajan, A; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV | 1 |
| Feller, DR; Kocarek, TA | 1 |
| Bernard, N; Cuisinaud, G; Ferry, N; Gardes, E; Labeeuw, M; Pozet, N; Sassard, J; Zech, PY | 1 |
| Hellwich, KH; Oelschläger, H; Rothley, D; Schmidt, W | 2 |
| Bonner, FW; Gibson, GG; Goldfarb, PS; Makowska, JM | 1 |
| Milano, M; Rao, MS; Reddy, JK; Subbarao, V; Yeldandi, AV | 1 |
| Kasai, H; Nishimura, S; Okada, Y; Rao, MS; Reddy, JK | 1 |
| Alvares, K; Mangino, M; Rao, MS; Reddy, JK; Thangada, S; Usman, MI | 1 |
| Basista, M; Bieroń, K; Czarnecka, H; Dembińska-Kieć, A; Grodzińska, L; Kedzior, A; Kostka-Trabka, E; Slawiński, M; Trabka, E; Zmuda, A | 1 |
| Angelin, B; Einarsson, K; Ståhlberg, D | 1 |
| Capek, R; Fischer, S; Groh, G; Hanefeld, M; Lindner, J; Nehring, A; Rössger, G; Schulze, J | 1 |
| Katoh, H; Kawashima, Y; Kozuka, H; Takegishi, M; Watanuki, H | 1 |
| Hirose, A; Katoh, H; Kawashima, Y; Kozuka, H; Takegishi, M; Watanuki, H | 1 |
| Beer, D; Coloma, J; Glauert, HP; Goldsworthy, TL; Pitot, HC; Rao, MS; Schwarz, M; Xu, YD | 1 |
| Hirose, A; Kawashima, Y; Kozuka, H | 4 |
| Rao, MS; Reddy, JK; Subbarao, V | 2 |
| Jacotot, B; Moreau, P; Tillement, JP | 1 |
| Fournel, S; Magdalou, J; Pinon, P; Siest, G | 1 |
| Isono, H; Katoh, H; Kawashima, Y; Kozuka, H; Watanuki, H | 1 |
| Milano, M; Prasad, JD; Rao, MS; Reddy, JK | 1 |
| Kennard, CH; Smith, G | 1 |
| Dwivedi, RS; Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Bonner, FW; Eason, CT; Howells, DD; Pattison, A | 1 |
| Marlowe, C; Rao, MS; Reddy, JK; Waddell, WJ | 1 |
| Clark, TD; Glauert, HP | 1 |
| Ojeda, G; Portolés, A; Portolés, MP; Rojo, JM | 1 |
| Agius, L; Alberti, KG; Gerondaes, P | 2 |
| Krause, BR; Newton, RS | 1 |
| Feller, DR; Kim, SK; Newman, HA; Romstedt, K; Witiak, DT | 1 |
| Kokkinakis, DM; Rao, MS; Reddy, JK; Subbarao, V | 1 |
| Dragacci, S; Fournel-Gigleux, S; Hamar-Hansen, C; Lafaurie, C; Magdalou, J; Siest, G | 1 |
| Bonner, FW; Eason, CT; Henry, DC; Howells, DD; Pattison, A; Spencer, AJ | 1 |
| Oelschläger, H; Rothley, D; Schmidt, W | 1 |
| Agius, L; Bartlett, K; Bhuiyan, AK; Sherratt, HS | 1 |
| Castro, M; Gómez-Coronado, D; Herrera, E; Lasunción, MA; Martín, A; Quack, G | 1 |
| Bonnefis, MT; Infante, R; Petit, D; Rey, C | 1 |
| Arichi, S; Inoue, K; Ohno, T; Tani, T | 1 |
| Bonner, FW; Eason, CT; Howells, DD; Pattison, A; Spencer, AJ | 1 |
| Palmer, RH | 1 |
| Hunninghake, DB; Peters, JR | 1 |
| Jover, E; López, IM; Rodriguez, F | 1 |
| Ho, LT; Lam, HC; Li, SH; Tang, KT; Wang, JT | 1 |
| Garvis, WJ; Kasiske, BL; Keane, WF; O'Donnell, MP | 1 |
| Caslake, MJ; Cruickshank, A; Demant, T; Kilday, C; Packard, CJ; Series, JJ; Shepherd, J | 1 |
| Borkowski, L; Kwapiszewski, W | 1 |
| Carrino, JJ; Goel, SK; Hashimoto, T; Laffler, TG; Lalwani, ND; Nemali, MR; Osumi, T; Reddy, JK; Reddy, MK; Sperbeck, SJ | 1 |
| Alvares, K; Lalwani, ND; Parikh, I; Reddy, JK; Reddy, MK; Reddy, MN | 1 |
| Evarts, RE; Lalwani, ND; Rao, MS; Reddy, JK; Reddy, MK; Singh, B; Thorgeirsson, S; Usman, MI | 1 |
| Armijo Castro, F; Gutierrez Fuentes, JA; Pire Solis, I; Vazquez Lopez, F | 1 |
| Graben, N; Hartmann, H; Merk, W; Nikolaus, C; Schlierf, G; Schwandt, P | 1 |
| Evans, JG; Gangolli, SD; Gray, TJ; Kozlen, SL; Lake, BG; Young, PJ | 1 |
| Cleary, MP; Kasiske, B; Keane, WF; O'Donnell, MP | 1 |
| Holm, E; Schatton, W | 1 |
| Foliot, A; Mallet, L; Touchard, D | 1 |
| Lalwani, ND; Rao, MS; Reddy, JK; Reddy, MK; Usman, MI | 1 |
| Garg, NK; Mehdi, H; Misra, SK; Sharma, AK | 1 |
| Aarsaether, N; Aarsland, A; Berge, RK; Lygre, T; Stensland, E | 1 |
| Amigo, L; Bronfman, M; Morales, MN | 1 |
| Anwer, K; Gabis, J; Gojer, C; Romstedt, K | 1 |
| Capdevila, J; Estabrook, RW; Falck, JR; Kim, YR; Manna, S; Martin-Wixtrom, C | 1 |
| MacDonald, RS; Swan, PB | 1 |
| Betz, E; Hämmerle, H | 1 |
| Calvo, R; Carlos, R; Erill, S | 1 |
| Bakir, R; Chanu, B; Djian, F; Goy-Loeper, J; Rouffy, J | 1 |
| Esteva de Antonio, I; Soringer Escofet, FJ | 1 |
| Joven, J | 1 |
| Earley, K; Goel, SK; Gupta, RC; Reddy, JK; Singh, B | 1 |
| Altmayer, P; Garrett, ER | 2 |
| Furuta, S; Hashimoto, T; Miyazawa, S; Osumi, T; Ozasa, H | 1 |
| Chasseaud, LF; Schatton, W; Taylor, T; Waller, AR | 1 |
| Katoh, H; Kawashima, Y; Kozuka, H; Tachibana, Y; Takegishi, M; Watanuki, H | 1 |
| Bardosi, A; Goebel, HH; Scheidt, P | 1 |
| Davidson, JF; Lorimer, AR; Simpson, IA; Walker, ID | 1 |
| Borkowski, L; Gawrońska-Szklarz, B; Kwapiszewski, W; Samochowiec, L; Wójcicki, J | 1 |
| Hartmann, G; Stähelin, HB | 1 |
| Goebel, KM; Hausmann, L; Kaffarnik, H; Schneider, J; Schubotz, R; Zöfel, P | 1 |
| Katoh, H; Kawashima, Y; Kozuka, H | 3 |
| Kawashima, Y; Kozuka, H | 1 |
| Katoh, H; Kawashima, Y; Kozuka, H; Nakajima, S | 1 |
| Lalwani, ND; Qureshi, SA; Rao, MS; Reddy, JK; Reddy, MK; Scarpelli, DG | 1 |
| Basi, N; Bermejo, P; Bruseghini, L; Freixes, J; Giráldez, A; Vilageliu, J | 1 |
| Boag, DE; Lorimer, AR; Packard, CJ; Shepherd, J; Stewart, JM | 1 |
| Honková, M; Kunesová, M; Mares, P; Skorepa, J; Zeman, M | 1 |
| Bochenek, W; Słowińska, R; Unlot, J | 1 |
| Santafé Oroz, J; Segarra Domènech, J | 1 |
| Odum, J; Orton, TC | 1 |
| Angelin, B; Einarsson, K; Leijd, B | 1 |
| Díez, MM; Fernández, A; Gil, M; Lasierra, J; Velázquez, E; Viladés, E | 1 |
| Gangolli, SD; Gray, TJ; Hodder, KD; Lake, BG; Stubberfield, CR; Tredger, JM; Williams, R | 1 |
| Awasthi, YC; Goel, SK; Reddy, JK; Singh, SV | 1 |
| Birkett, DJ; Miners, JO; Robson, RA | 1 |
| Díaz Méndez, M; Priego, JG | 1 |
| Barré, J; Benattar, C; Houin, G; Lindenbaum, A; Shastri, RA; Tillement, JP | 1 |
| de la Sierra, L; Gesto Castromil, R; Lázaro Campillo, T; Moreno, R; Pujadas, J; Villafana, W | 1 |
| Hoppe, HJ; Johnson, KI; Schatton, W | 1 |
| Walmsley, LM | 1 |
| Degenring, FH; Hotz, W; Schatton, W | 1 |
| Fahl, WE; Lalwani, ND; Reddy, JK | 1 |
| Meffin, PJ; Veenendaal, JR; Zilm, DM | 2 |
| Meffin, PJ; Zilm, DM | 1 |
| Badimón, JJ; Cánovas, M; Padró, T; Vidal, M; Villaverde, CA | 1 |
| Calatayud, JM | 1 |
| Bruseghini, L; Freixes, J; Vilageliu, J | 2 |
| Dengler, HJ; Robertz, GM | 1 |
| Lalwani, ND; Rao, MS; Reddy, JK; Watanabe, TK | 1 |
| Barre, J; Houin, G; Pinchon, B; Shastri, RA; Tillement, JP | 1 |
| Harris, RA; Paxton, R | 1 |
| Gómez, JM; Morató, J; Soler, J; Vinzia, C | 1 |
| Meffin, PJ; Rowe, BJ | 1 |
| Rüth, E; Vollmar, J | 1 |
| Schatton, W | 1 |
| Connor, WE; Cook, SF; Illingworth, DR; Olsen, GD; Sexton, GJ; Wendel, HA | 1 |
| Kaffarnik, H; Schneider, J; Schubotz, R; Zöfel, P | 1 |
| Fischer, H; Oster, P; Roche, A; Schellenberg, B; Schlierf, G; Stiehl, A; Vollmar, J | 1 |
| Keller, M; Lang, PD; Middelhoff, G; Mordasini, R; Oster, P; Riesen, W | 1 |
| Artús, JJ; Bruseghini, L; Freixes, J; Ribalta, JM; Roma, E; Salvador, L; Vilageliu, J | 1 |
| Holler, HD; Janka, HU; Mehnert, H; Standl, A | 1 |
| Dorda, W; Kostner, GM; Mühlhauser, I; Prager, R; Schernthaner, G; Zechner, R | 1 |
| Reuter, W | 3 |
| Lang, PD; Vollmar, J | 1 |
| Day, AJ; Hudson, K; Mojumder, S | 1 |
| Hanefeld, M; Kadner, E; Kemmer, C | 1 |
| Kurlat, MI; Neuman, J; Neuman, MP | 1 |
| Olsson, AG; Orö, L | 1 |
| Djaja, S; Machalke, K; Richter, E | 1 |
| Fahimi, HD; Hartig, F; Ozel, M; Reinicke, A; Stegmeier, K; Sujatta, M; Yokota, S | 1 |
| Bargalló, MA; Basi, N; Beascoa, E; Bermejo, P; Bruseghini, L; Gimenez, F; Giráldez, A; Gras, J; Llenas, J; Zapatero, J | 1 |
| Lageder, H | 1 |
| Abshagen, U; Marinow, J; Spörl-Radun, S | 1 |
| Boberg, J; Gustafsson, IB; Hellsing, K; Ledermann, H; Lithell, H; Ostlund-Lindqvist, AM; Vessby, B | 1 |
| Armijo, M; Ortega, MP; Priego, JG; Sunkel, C | 1 |
| Granzer, E; Weithmann, KU | 1 |
| Altomonte, L; De Cunto, F; Greco, AV; Mingrone, G; Negrini, A | 1 |
| Kokot, F; Szczechowska, E | 1 |
| Dick, TB; Ledermann, HM; Marples, J; Whittington, J | 1 |
| Jones, E; Richold, M | 1 |
| Olivella, J; Vicens, B | 1 |
| del Rio, A; Ferreira, IJ; González-Viejo, N; Vicens, B | 1 |
| DiBlasio, P; Gasparini Casari, M; Palmieri, B; Zirilli, E | 1 |
| Grützmacher, P; Lang, W; Scheuermann, E | 1 |
| Casasnovas Lenguas, JA; Cornudella Lacasa, R; del Río Ligorit, A; Ferreira Montero, IJ; Gutiérrez Martín, M | 1 |
| Gardner, MR; Garrett, ER | 1 |
| von Bock und Polach, U | 1 |
| Day, AJ; Hudson, K; Marceglia, A | 1 |
| Biddlecome, CE; Edelson, J; Koblantz, C; Park, GB | 1 |
| Bode, G; Ditschuneit, H; Hutt, V; Klör, HU; Wechsler, JG | 1 |
| Drosner, M; Janetschek, P; Schwandt, P; Weisweiler, P | 1 |
| Lazarow, PB; Leroy-Houyet, MA; Shio, H | 1 |
| Lang, PD; Mertz, DP; Vollmar, J | 1 |
| Boulu, RG; Debray, M; Di Giulio, S; Drüeke, T; Lacour, B; Nicolaï, A | 1 |
| Davignon, J; Dubreuil-Quidoz, S; LeLorier, J; Lussier-Cacan, S | 1 |
| Lehmann-Leo, W; Luley, C; Scheffler, W; Schilling, A; Schwartzkopff, W; Wegscheider, K | 1 |
| Azanza Perea, JR; Honorato Pérez, J | 1 |
| Ledermann, H; Lithell, H; Vessby, B | 1 |
| Heidland, A; Hörl, M; Hörl, WH | 1 |
| Udelhoven, P | 1 |
| Anderson, P; Norbeck, HE | 2 |
| Fringes, B; Riede, UN; von Deimling, O | 1 |
| Kolb, S; Sailer, D | 1 |
| Day, AJ; Hudson, K | 1 |
| Braeuning, C; Middelhoff, G; Schlierf, G; Wirth, A | 1 |
| Kłosiewicz-Latoszek, L; Naruszewicz, M; Nowicka, G; Szostak, WB | 1 |
| Ewert, M; Nachev, P; Oelschläger, H; Rothley, D | 1 |
| Ribalta, JM; Ristol, P; Torres, A | 1 |
| Bagaria, A; Bruseghini, L; Vilageliu, J | 1 |
| Bruseghini, L; Ribalta, JM; Torres, A; Vilageliu, J; Zapatero, D | 1 |
| Bruseghini, L; Sanfeliu, C; Zapatero, J | 3 |
| Basi, N; Bruseghini, L; Sanfeliu, C; Vilageliu, J; Zapatero, J | 1 |
| Bruseghini, L; Dalmau, J; Vicens, B; Zapatero, J | 2 |
| Bruseghini, L; Conti, F; Santaniello, E; Vilageliu, J | 1 |
| Bracons, R; Bruseghini, L; Demichelis Genesio, MA; Vicens, B; Zapatero, J | 1 |
| Hofmann, H; Holler, HD; Stratmann, FW | 1 |
| Bertuletti, R; Carini, M; Maffei, FR; Tofanetti, O | 1 |
| Göhmann, E; Mertz, DP; Suermann, I | 1 |
| Schwandt, P; Weisweiler, P | 1 |
| Azarnoff, DL; Hignite, CE; Huffman, DH; Lemons, S; Tschanz, C; Wiese, H | 1 |
| Meffin, PJ; Veenendaal, JR | 1 |
| Ditschuneit, H; Hutt, V; Klör, HU; Wechsler, JG | 2 |
| Hausmann, L; Kaffarnik, H; Mühlfellner, G; Mühlfellner, O; Schneider, J; Schubotz, R | 1 |
| Seidel, D; Walli, AK | 1 |
| Bock, KD; Heidemann, H | 1 |
| Kjellin, KG; Ledermann, H; Noring, L | 1 |
| de la Fuente, R; Santos, M | 1 |
| Bruneder, H; Klein, HJ | 1 |
| Bock, KD | 1 |
| Ikeda, K; Kurono, Y; Ohta, N; Yotsuyanagi, T | 1 |
| Kaufmann, B; Ledermann, H | 1 |
| Furuta, S; Hashimoto, T; Miyazawa, S | 1 |
| Carini, M; Facino, RM | 1 |
| Bjornsson, TD; Blaschke, TF; Meffin, PJ; Peters, FA | 1 |
| Wolf, MS; Zimmerman, JJ | 1 |
| Altomonte, L; Ghirlanda, G; Greco, AV; Manna, R; Mingrone, G; Pala, MA; Rebuzzi, A | 1 |
| Steger, W | 1 |
| Casanello-Ertl, D; Duducgian-Vartavarian, L; Pardridge, WM | 1 |
| Haller, H; Hanefeld, M; Jaross, W; Kemmer, C; Kunze, KD; Leonhardt, W | 1 |
| Campbell, IM; Emmons, GT; Malloy, JM; McManus, IR; Rosenblum, ER | 1 |
| Abshagen, U; Kaufmann, B; Kösters, W; Lang, PD | 1 |
| Füsgen, I; Summa, JD | 1 |
| Baldwin, JR; Feller, DR; Witiak, DT | 1 |
| Bachmann, C; Fragiacomo, C; Noseda, G; Weidmann, P | 1 |
| Calder, D; Luley, C; Scheffler, W; Schilling, A; Schwartzkopff, W | 1 |
| Mertz, DP | 1 |
| Schilling, A; Schwartzkopff, W | 1 |
| Casanello-Ertl, D; Duducgian-Vartavarian, L; Jones, MR; Kopple, JD; Pardridge, WM | 1 |
| Baldwin, LA; Calabrese, EJ; Donohue, M; Kostecki, PT; Leonard, DA | 1 |
| Bourget, P; Broise, I; Gabilan, JC; Quinquis-Desmaris, V | 1 |
| Cherkaoui Malki, M; el Kebbaj, MH; Latruffe, N | 1 |
| Blaauboer, BJ; Hassing, GA; Jahn, U; Mennes, WC; Schmid, BP; Timmerman, A; van Sandwijk, K; Wortelboer, HM | 1 |
| Dujovne, CA; Lozada, A | 1 |
| Barra, J; Fessi, H; Jardel, A; Puisieux, F; Taburet, AM | 1 |
| Boscá, F; Canudas, N; Miranda, MA; Vargas, F | 1 |
| Hatayama, I; Sato, K; Tsuchida, S; Yokoyama, Y | 1 |
| Accatino, L; Amigo, L; Andrade, L; Chianale, J; Gonzalez, S; Nervi, F; Pizarro, M; Rigotti, A; Vollrath, V; Wielandt, AM | 1 |
| Galloway, SM; Johnson, TE; Ledwith, BJ; Manam, S; Nichols, WW; Pauley, CJ; Wagner, LK | 1 |
| de Wit, EC; Huisman, H; Kaptein, A; Neele, DM; Princen, HM | 1 |
| Deyashiki, Y; Hara, A; Ishikura, S; Katagiri, Y; Kato, M; Matsuura, K; Miyabe, Y; Sugiyama, T | 1 |
| Kockx, M; Kooistra, T; Princen, HM | 1 |
| Buhler, DR; Haasch, ML; Henderson, MC | 1 |
| Derudas, B; Gervois, PP; Gonzalez, FJ; Kockx, M; Kooistra, T; Peters, JM; Poulain, P; Princen, HM; Staels, B | 1 |
| Wallace, KB; Zhou, S | 1 |
| Evans, DC; Heavens, R; Jack, A; Meneses-Lorente, G; Surry, DD | 1 |
| Amoroso, R; Ferorelli, S; Loiodice, F; Longo, A; Molfetta, A; Tortorella, V | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Laurora, S; Pizzimenti, S | 1 |
| Fujisaki, K; Itoh, Y; Maiguma, T; Makino, K; Oishi, R; Sasaguri, T; Takahashi-Yanaga, F; Teshima, D | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Fraioli, A; Laurora, S; Maggio, M; Pizzimenti, S; Reffo, P | 1 |
| Ammerschlaeger, M; Beigel, J; Klein, KU; Mueller, SO | 1 |
| Baldwin, GS; Ford, J; Lachal, S; Shulkes, A | 1 |
| Carvalho, F; Guilhermino, L; Nunes, B | 3 |
| Fernandes, D; Porte, C; Schnell, S | 1 |
5 review(s) available for clofibric acid and clofibrate
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Effects of fibric acid derivatives on biliary lipid composition.
Topics: Bezafibrate; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Propionates; Random Allocation | 1987 |
Effect of fibric acid derivatives on blood lipid and lipoprotein levels.
Topics: Anticholesteremic Agents; Bezafibrate; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Pentanoic Acids | 1987 |
[Pharmacologic therapy of atherosclerosis (I). Current possibilities].
Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Clofibrate; Clofibric Acid; Fenofibrate; Gemfibrozil; Glycosaminoglycans; Humans; Ion Exchange Resins; Lipoproteins; Nicotinic Acids; Pentanoic Acids; Probucol | 1983 |
Drug interactions with fibric acids.
Topics: Anticoagulants; Bezafibrate; Clofibrate; Clofibric Acid; Contraceptives, Oral; Coronary Disease; Drug Interactions; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Lipids | 1994 |
33 trial(s) available for clofibric acid and clofibrate
| Article | Year |
|---|---|
[New drug combination for medical management of hyperlipemia: clinical study].
Topics: Aged; Blood Glucose; Body Weight; Cholesterol; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Drug Combinations; Humans; Hyperlipidemias; Hypolipidemic Agents; Inositol; Middle Aged; Nicotinic Acids; Time Factors; Triglycerides | 1977 |
[Etofibrate and clofibrate in double blind study].
Topics: Anticholesteremic Agents; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Humans; Hypercholesterolemia; Nicotinic Acids; Placebos | 1976 |
[Intensive basic therapy decreases the need for drug treatment and improves glucose control: an important result of the diabetes intervention study].
Topics: Clinical Trials as Topic; Clofibrate; Clofibric Acid; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diet, Diabetic; Dietary Fats; Dietary Fiber; Double-Blind Method; Exercise; Humans; Hypoglycemic Agents; Insulin; Physical Therapy Modalities; Random Allocation | 1988 |
Effects of fibric acid derivatives on biliary lipid composition.
Topics: Bezafibrate; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Propionates; Random Allocation | 1987 |
The antilipemic effectiveness of aluminium clofibrate on hyperlipidemic patients with or without diabetes mellitus.
Topics: Adult; Aged; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Diabetes Complications; Double-Blind Method; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged | 1987 |
Comparative evaluation of the effects of ciprofibrate and fenofibrate on lipids, lipoproteins and apoproteins A and B.
Topics: Adult; Apolipoproteins A; Apolipoproteins B; Clofibrate; Clofibric Acid; Drug Evaluation; Female; Fenofibrate; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Male; Propionates; Time Factors | 1985 |
[Long-term effect of alufibrate in various types of hyperlipidaemia (author's transl)].
Topics: Adult; Aged; Aluminum; Cholesterol; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Drug Evaluation; Drug Tolerance; Female; Humans; Hyperlipidemias; Lipids; Lipoproteins; Male; Middle Aged; Phospholipids; Time Factors; Triglycerides | 1974 |
[Therapeutic effects of bezafibrate in hyperlipidemia].
Topics: Adult; Aged; Bezafibrate; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged | 1983 |
[Study of the antilipemic effect of etofibrate (Lipo-Merz)].
Topics: Adult; Aged; Anticholesteremic Agents; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged | 1983 |
[Pharmacology and mechanism of action of etofibrate].
Topics: Animals; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipids | 1982 |
Ciprofibrate in the therapy of type II hypercholesterolemia. A double-blind trial.
Topics: Adult; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Fibric Acids; Humans; Hyperlipoproteinemia Type II; Male | 1982 |
[The effect of bezafibrate on biliary lipids (author's transl)].
Topics: Adult; Bezafibrate; Bile; Clofibrate; Clofibric Acid; Drug Evaluation; Humans; Hyperlipoproteinemias; Lipids | 1980 |
[Carbohydrate metabolism in bezafibrate therapy. Controlled study of glibenclamide-treated diabetics with hyperlipidemia].
Topics: Aged; Bezafibrate; Carbohydrate Metabolism; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Diabetes Complications; Diabetes Mellitus; Glyburide; Humans; Hyperlipidemias; Hypolipidemic Agents; Middle Aged; Patient Compliance | 1982 |
Effect of bezafibrate on plasma lipids, lipoproteins, apolipoproteins AI, AII and B and LCAT activity in hyperlipidemic, non-insulin-dependent diabetics.
Topics: Aged; Apolipoprotein A-II; Apolipoproteins; Apolipoproteins A; Apolipoproteins B; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Clofibrate; Clofibric Acid; Diabetes Mellitus; Female; Humans; Hyperlipoproteinemias; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Phosphatidylcholine-Sterol O-Acyltransferase | 1982 |
[Lipid-lowering effect of etofibrate, bezafibrate and xanthinol nicotinate in patients with hyperlipoproteinemias].
Topics: Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Theophylline; Xanthinol Niacinate | 1982 |
[Comparative double-blind investigation of bezafibrate and clofibrate in patients with primary hyperlipoproteinaemia].
Topics: Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemias; Male; Placebos; Triglycerides | 1980 |
Steady-state kinetics of bezafibrate and clofibrate in healthy female volunteers.
Topics: Administration, Oral; Adult; Bezafibrate; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Drug Administration Schedule; Female; Half-Life; Humans; Hypolipidemic Agents; Kinetics | 1980 |
[Double-blind study of the therapeutic activity of a new hypolipemic drug: etofibrate].
Topics: Adult; Aged; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Male; Middle Aged | 1981 |
[Comparison of the lipid-lowering agents clofibrate and bezafibrate in patients with hyperlipoproteinemias IIa and IIb].
Topics: Adult; Bezafibrate; Cholesterol; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Humans; Hyperlipoproteinemia Type II; Male; Middle Aged; Random Allocation; Triglycerides | 1981 |
Comparative study of once and 3-times daily regimens of bezafibrate in patients with primary hyperlipoproteinaemia.
Topics: Adult; Aged; Alkaline Phosphatase; Bezafibrate; Cholesterol; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Creatinine; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipids; Male; Middle Aged; Urea | 1981 |
Plafibride: clinical trial of a new platelet antiaggregating agent.
Topics: Adenosine Diphosphate; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Dipyridamole; Double-Blind Method; Humans; Middle Aged; Platelet Aggregation; Time Factors | 1981 |
Double-blind study on the activity of plafibride in the treatment of type IV hyperlipoproteinemia.
Topics: Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Humans; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipids; Male; Middle Aged; Platelet Function Tests | 1981 |
Clinical research into the hypolipemic and platelet antiaggregant activity of plafibride, Carried out in double-blind conditions and in comparison with clofibrate.
Topics: Adenosine Diphosphate; Adult; Aged; Cholesterol; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Lipoproteins; Male; Middle Aged; Platelet Aggregation; Triglycerides | 1981 |
Improvement of hyperlipidaemia by bezafibrate treatment in RDT patients.
Topics: Adult; Bezafibrate; Cholesterol; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Humans; Hyperlipidemias; Hypolipidemic Agents; Kidney Failure, Chronic; Middle Aged; Renal Dialysis; Triglycerides | 1981 |
[Controlled clinical trial of a new drug (plafibride) for the treatment of hyperlipoproteinemia type IV (author's transl)].
Topics: Adult; Aged; Clinical Trials as Topic; Clofibrate; Clofibric Acid; Double-Blind Method; Female; Humans; Hyperlipoproteinemia Type IV; Lipids; Male; Middle Aged; Platelet Function Tests; Random Allocation | 1982 |
[Efficacy of bezafibrate and fenofibrate on elevated blood lipids in HLP type IIa, IIb and IV].
Topics: Adult; Aged; Anticholesteremic Agents; Bezafibrate; Clofibrate; Clofibric Acid; Female; Fenofibrate; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipids; Male; Middle Aged; Propionates | 1982 |
Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar.
Topics: Adult; Apolipoproteins; Bezafibrate; Body Weight; Cholesterol; Cholesterol, LDL; Clofibrate; Clofibric Acid; Drug Therapy, Combination; Female; Galactans; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Mannans; Middle Aged; Plant Gums; Polysaccharides | 1982 |
Plafibride tolerance trial at increasing doses in healthy volunteers.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Blood Cell Count; Blood Glucose; Clofibrate; Clofibric Acid; Double-Blind Method; Hemodynamics; Humans; Hypolipidemic Agents | 1981 |
Plafibride tolerance trial in healthy volunteers.
Topics: Adult; Aspirin; Clofibrate; Clofibric Acid; Double-Blind Method; Erythrocyte Count; Humans; Hypolipidemic Agents; Leukocyte Count; Lipids; Platelet Aggregation | 1981 |
Clinical trials of plafibride in geriatric patients.
Topics: Aged; Arteriosclerosis; Clofibrate; Clofibric Acid; Female; Humans; Hypolipidemic Agents; Lipids; Male; Middle Aged; Platelet Aggregation; Time Factors | 1981 |
[Treatment of hyperlipoproteinaemia in diabetic patients (author's transl)].
Topics: Adult; Aged; Bezafibrate; Blood Glucose; Cholesterol; Clofibrate; Clofibric Acid; Diabetes Complications; Female; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged; Phospholipids; Placebos; Triglycerides | 1981 |
[Therapy of lipoproteinemia. Comparison between Lipo-Merz retard and a commercial combination drug].
Topics: Adult; Aged; Cholesterol; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Female; Humans; Hyperlipoproteinemias; Male; Middle Aged; Niacin; Nicotinic Acids; Triglycerides | 1980 |
[An alternative in the therapy of primary hyperlipemias: etofibrate in depot preparations].
Topics: Adolescent; Adult; Aged; Cholesterol; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 1980 |
262 other study(ies) available for clofibric acid and clofibrate
| Article | Year |
|---|---|
Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.
Topics: Adenylyl Cyclases; Adrenergic beta-3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Drug Inverse Agonism; Humans; Molecular Structure; Receptors, Adrenergic, beta-3; Stereoisomerism; Structure-Activity Relationship | 2008 |
Discovery, synthesis and in combo studies of a tetrazole analogue of clofibric acid as a potent hypoglycemic agent.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Binding Sites; Blood Glucose; Catalytic Domain; Clofibric Acid; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Humans; Hydrogen Bonding; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Rats; Structure-Activity Relationship; Tetrazoles | 2013 |
Effects of etofibrate, clofibrate and nicotinic acid on the cyclic AMP-protein kinase system in rats.
Topics: Adipose Tissue; Animals; Clofibrate; Clofibric Acid; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Insulin; Liver; Male; Nicotinic Acids; Protein Binding; Protein Kinases; Rats | 1979 |
Effects of etofibrate, clofibrate and nicotinic acid on lipid metabolism in normolipemic rats.
Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Lipid Metabolism; Lipids; Lipoproteins; Liver; Male; Nicotinic Acids; Phospholipids; Rats | 1979 |
Effects of etofibrate, clofibrate and nicotinic acid on lipid metabolism in hyperlipidemic rats.
Topics: Animals; Clofibrate; Clofibric Acid; Diet; Hypercholesterolemia; Hyperlipidemias; Lipid Metabolism; Liver; Male; Nicotinic Acids; Rats; Triglycerides | 1979 |
The immediate and long term effects of clofibrate on the metabolism of the perfused rat liver.
Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Fatty Acids, Nonesterified; Glucose; In Vitro Techniques; Lactates; Lipid Metabolism; Lipoproteins; Liver; Liver Glycogen; Male; Oxygen Consumption; Perfusion; Pyruvates; Rats; Triglycerides | 1979 |
Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat.
Topics: Adolescent; Adult; Animals; Chemical Phenomena; Chemistry; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gilbert Disease; Humans; Liver; Male; Microsomes, Liver; Middle Aged; Organ Size; Phenobarbital; Rats; Sleep | 1979 |
Species variation in the taurine conjugation of clofibric acid [proceedings].
Topics: Animals; Cats; Clofibrate; Clofibric Acid; Dogs; Ferrets; Guinea Pigs; Humans; Rabbits; Rats; Species Specificity; Taurine | 1979 |
Treatment of hyperlipoproteinemia type II with etofibrate.
Topics: Body Weight; Cholesterol; Clofibrate; Clofibric Acid; Glucose Tolerance Test; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Liver Function Tests; Male; Middle Aged; Nicotinic Acids; Time Factors | 1979 |
Effects of phenylbutazone, tolbutamide, and clofibric acid on binding of racemic warfarin and its enantiomers to human serum albumin.
Topics: Binding, Competitive; Clofibrate; Clofibric Acid; Humans; Kinetics; Phenylbutazone; Protein Binding; Serum Albumin; Stereoisomerism; Tolbutamide; Warfarin | 1979 |
Metabolic effects of a new hypolipidemic agent, ciprofibrate.
Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Fatty Acids, Nonesterified; Fibric Acids; Hypolipidemic Agents; Lipase; Norepinephrine; Polyethylene Glycols; Rats | 1979 |
[The range and lipid-lowering effect of etofibrate as a retard-preparation in patients with hyperlipoproteinemia type IIa (author's transl)].
Topics: Adult; Aged; Anticholesteremic Agents; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Female; Humans; Hyperlipoproteinemia Type II; Male; Middle Aged | 1979 |
[A comparison of bezafibrate and clofibrate in type II B and type IV hyperlipoproteinemia].
Topics: Adult; Aged; Bezafibrate; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Male; Middle Aged | 1979 |
[Induction of fatty acid oxidation in peroxisomes of rat liver by magnesium-4 chlorophenoxyisobutyrate (Mg-CPIB)].
Topics: Animals; Catalase; Clofibrate; Clofibric Acid; Fatty Acids; In Vitro Techniques; Liver; Male; Microbodies; Organoids; Oxidation-Reduction; Rats | 1979 |
[Treatment of various types of hyperlipoproteinaemia with a combination of Mg-chlorophenoxy-isobutyrate and mesoinositol-hexanicotinate (author's transl)].
Topics: Adult; Aged; Cholesterol; Clofibrate; Clofibric Acid; Drug Combinations; Female; Humans; Hyperlipoproteinemias; Inositol; Lipids; Male; Middle Aged; Nicotinic Acids; Triglycerides | 1979 |
[Influence of etofibrate on plasmaviscosity in hyperlipoproteinemias (author's transl)].
Topics: Blood Viscosity; Cholesterol; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipidemias; Male; Middle Aged; Triglycerides | 1978 |
[ITA 104, a product of antiplatelet aggregation activity].
Topics: Adenosine Diphosphate; Animals; Aspirin; Clofibrate; Clofibric Acid; Depression, Chemical; Dogs; Platelet Aggregation; Rats | 1978 |
Effects of joint exposures to selected peroxisome proliferators on hepatic acyl-CoA oxidase activity in male B6C3F1 mice.
Topics: Acyl-CoA Oxidase; Animals; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Fibric Acids; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Microbodies; Oxidoreductases | 1992 |
Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agents.
Topics: Animals; Aspirin; Cell Division; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Female; Fibric Acids; Hypolipidemic Agents; L-Lactate Dehydrogenase; Microbodies; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Trypan Blue; Valproic Acid | 1992 |
Induction protocols for the cytochrome P450IVA subfamily in animals and primary hepatocyte cultures.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Diethylhexyl Phthalate; Enzyme Induction; Fibric Acids; Genetic Techniques; Isoenzymes; Liver; Rats; Rats, Inbred Strains; RNA, Messenger; Species Specificity; Transcription, Genetic | 1991 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresis, Gel, Two-Dimensional; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Mice; Proteins; Pyrimidines | 1991 |
Effect of ciprofibrate, bezafibrate, and LY171883 on peroxisomal beta-oxidation in cultured rat, dog, and rhesus monkey hepatocytes.
Topics: Acetophenones; Animals; Autacoids; Azoles; Bezafibrate; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Dogs; Dose-Response Relationship, Drug; Female; Fibric Acids; Glucagon; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Microbodies; Microscopy, Electron; NAD; Oxidation-Reduction; Rats; Tetrazoles; Tyrosine Transaminase | 1990 |
Effect of dietary vitamin E on the development of altered hepatic foci and hepatic tumors induced by the peroxisome proliferator ciprofibrate.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Drug Synergism; Female; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Liver; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Vitamin E | 1990 |
On the mechanism of the hepatocarcinogenicity of peroxisome proliferators.
Topics: Animals; Caprylates; Carcinogens; Clofibrate; Clofibric Acid; DNA; DNA Damage; DNA Repair; Fibric Acids; Fluorocarbons; Liver; Liver Neoplasms; Male; Microbodies; Micronucleus Tests; Mutagenicity Tests; Nafenopin; Radiation, Ionizing; Rats; Rats, Inbred Strains; S Phase | 1991 |
Comparative studies on the influence of different fibrates on serum lipoproteins in endogenous hyperlipoproteinaemia.
Topics: Adult; Aged; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Colestipol; Female; Fenofibrate; Gemfibrozil; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Probucol | 1991 |
Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Clofibrate; Clofibric Acid; Coenzyme A Ligases; Cycloheximide; Fatty Acid Desaturases; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; gamma-Linolenic Acid; Linoleic Acid; Linoleic Acids; Linolenic Acids; Liver; Male; Microbodies; Microsomes, Liver; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins | 1990 |
Differential proto-oncogene mRNA induction from rats treated with peroxisome proliferators.
Topics: Acyl-CoA Oxidase; Animals; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Genes, myc; Genes, ras; Hypolipidemic Agents; Kidney; Liver; Male; Microbodies; Organ Specificity; Oxidoreductases; Proto-Oncogenes; Rats; Rats, Inbred F344; RNA, Messenger | 1990 |
Expression of liver peroxisomal proteins as compared to other organelle marker enzymes in rats treated with hypolipidemic agents.
Topics: Animals; Base Sequence; Cell Fractionation; Clofibrate; Clofibric Acid; DNA Probes; Fibric Acids; Hypolipidemic Agents; Immunoblotting; Liver; Male; Microbodies; Molecular Sequence Data; Organelles; Rats; Rats, Inbred F344; Rats, Inbred Strains; RNA, Messenger | 1990 |
[Lipid therapy with etofibrate. Reduction of multiple risk factors with an active substance. Report of an international seminar. 8-11 November 1989, Houston, Texas].
Topics: Clofibrate; Clofibric Acid; Humans; Hypolipidemic Agents | 1990 |
Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme.
Topics: Acyl Coenzyme A; Animals; Blood Platelets; Brain; Calcium; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diglycerides; Drug Synergism; Enzyme Activation; Fibric Acids; Glycerides; Histones; Humans; Microbodies; Palmitoyl Coenzyme A; Phosphatidylserines; Phosphorylation; Protein Kinase C; Rats | 1990 |
Effect of etofibrate on the development and the regression of atheromas in a rabbit model of atherosclerosis.
Topics: Animals; Arteriosclerosis; Clofibrate; Clofibric Acid; Disease Models, Animal; Hypolipidemic Agents; Rabbits | 1990 |
The effect of beclobric acid and clofibric acid on peroxisomal beta-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes.
Topics: Adult; Animals; Benzhydryl Compounds; Cells, Cultured; Clofibrate; Clofibric Acid; Fatty Acids; Female; Humans; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Microbodies; Microscopy, Electron; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1990 |
Induction of peroxisome proliferation in rainbow trout exposed to ciprofibrate.
Topics: Acyl-CoA Oxidase; Analysis of Variance; Animals; Blotting, Western; Body Weight; Catalase; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Hypolipidemic Agents; Liver; Microbodies; Organ Size; Oxidoreductases; Peptide Biosynthesis; Peptides; Time Factors; Trout | 1990 |
Effect of the peroxisome proliferator ciprofibrate on hepatic DNA synthesis and hepatic composition following partial hepatectomy in rats.
Topics: Administration, Oral; Animals; Body Weight; Clofibrate; Clofibric Acid; DNA; Female; Fibric Acids; Hepatectomy; Hypolipidemic Agents; Liver; Organ Size; Rats; Rats, Inbred Strains; Vitamin E | 1990 |
Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation.
Topics: Administration, Oral; Animals; Body Weight; Cell Division; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Fibric Acids; Glutathione Peroxidase; Hypolipidemic Agents; Male; Microbodies; Microsomes, Liver; Organ Size; Oxidoreductases; Oxidoreductases, N-Demethylating; Rats; Rats, Gunn; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity | 1990 |
In vivo and in vitro peroxisome proliferation properties of selected clofibrate analogues in the rat. Structure-activity relationships.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Acyl-CoA Oxidase; Animals; Body Weight; Cell Division; Cholesterol, Dietary; Clofibrate; Clofibric Acid; Glycolates; Male; Microbodies; Microsomes, Liver; Organ Size; Oxidoreductases; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship | 1990 |
Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.
Topics: Antibodies, Monoclonal; Asialoglycoprotein Receptor; Blotting, Western; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; ErbB Receptors; Fibric Acids; Fluorescent Antibody Technique; Isoelectric Point; Liver; Membrane Glycoproteins; Microbodies; Pyrimidines; Receptors, Immunologic; Sialoglycoproteins | 1990 |
Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Animals; Chlorides; Cholesterol; Clofibrate; Clofibric Acid; Electric Conductivity; Humans; Ion Channels; Male; Muscles; Platelet Aggregation; Rats; Stereoisomerism | 1987 |
Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogues.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Animals; Cell Membrane; Chlorides; Clofibrate; Clofibric Acid; Ion Channels; Male; Muscles; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship | 1987 |
Blockade of alpha-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters.
Topics: Animals; Carcinogens; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Hexachlorocyclohexane; Liver; Organ Size; Phenobarbital; Prazosin; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha | 1989 |
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle.
Topics: Animals; Binding Sites; Cell Membrane; Chloride Channels; Chlorides; Clofibrate; Clofibric Acid; Electric Conductivity; Ion Channels; Membrane Proteins; Muscles; Rats; Structure-Activity Relationship | 1988 |
Enantiomers of clofibric acid analogs have opposite actions on rat skeletal muscle chloride channels.
Topics: Animals; Chlorides; Clofibrate; Clofibric Acid; In Vitro Techniques; Ion Channels; Male; Muscles; Rats; Rats, Inbred Strains; Stereoisomerism | 1988 |
Gastric morphological changes including carcinoid tumors in animals treated with a potent hypolipidemic agent, ciprofibrate.
Topics: Animals; Callitrichinae; Carcinoid Tumor; Clofibrate; Clofibric Acid; Fibric Acids; Gastric Mucosa; Gastrins; Hypolipidemic Agents; Male; Mice; Microscopy, Electron; Rats; Rats, Inbred F344; Stomach Neoplasms | 1989 |
Potent antiplatelet effects of cyclic clofibric acid (CPIB) analogs on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Chromans; Clofibrate; Clofibric Acid; Epinephrine; Humans; Malondialdehyde; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1989 |
Comparison of dehydroepiandrosterone and clofibric acid treatments in obese Zucker rats.
Topics: Animals; Blood Glucose; Body Weight; Clofibrate; Clofibric Acid; Dehydroepiandrosterone; Disease Models, Animal; Eating; Female; Glucose Tolerance Test; Insulin; Liver; Obesity; Organ Size; Palmitoyl-CoA Hydrolase; Rats; Rats, Zucker | 1989 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Precancerous Conditions; Rats; Rats, Inbred F344 | 1989 |
Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fibric Acids; Gemfibrozil; Kinetics; Liver; Microbodies; Mixed Function Oxygenases; Oxidoreductases; Rats; Triglycerides | 1989 |
The influence of renal insufficiency and haemodialysis on the kinetics of ciprofibrate.
Topics: Adult; Aged; Clofibrate; Clofibric Acid; Female; Fibric Acids; Humans; Hypolipidemic Agents; Kidney Diseases; Male; Middle Aged; Renal Dialysis | 1989 |
[The pharmacokinetics of hypolipemic agents. 6. Is 2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-propane a metabolite of the hypolipemic ciprofibrate?].
Topics: Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1989 |
Species differences in the hepatic response to a potent peroxisome proliferator.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Fibric Acids; Guinea Pigs; Hypolipidemic Agents; Lauric Acids; Liver; Male; Microbodies; Rats; Rats, Inbred Strains; RNA, Messenger; Species Specificity | 1989 |
Evaluation of liver cell proliferation during ciprofibrate-induced hepatocarcinogenesis.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; DNA; Ethoxyquin; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Rats; Rats, Inbred F344 | 1989 |
Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Division; Clofibrate; Clofibric Acid; Deoxyguanosine; DNA; Fibric Acids; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Rats; Rats, Inbred F344 | 1989 |
An in vitro demonstration of peroxisome proliferation and increase in peroxisomal beta-oxidation system mRNAs in cultured rat hepatocytes treated with ciprofibrate.
Topics: Animals; Blotting, Northern; Catalase; Cells, Cultured; Clofibrate; Clofibric Acid; Cycloheximide; Fibric Acids; Hypolipidemic Agents; Liver; Male; Microbodies; Oxidation-Reduction; Protein Biosynthesis; Proteins; Rats; Rats, Inbred F344; RNA, Messenger | 1989 |
[Effectiveness of etofibrate in arteriosclerosis obliterans. Pilot study in hyperlipidemic patients with arteriosclerosis obliterans].
Topics: Adult; Arteriosclerosis Obliterans; Cholesterol, HDL; Clofibrate; Clofibric Acid; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Male; Triglycerides | 1989 |
[The pharmacokinetics of antilipemic agents. 5. Is 2-(4-hydroxyphenoxy)-2-methylpropionic acid a metabolite of the antilipemic ciprofibrate?].
Topics: Clofibrate; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1989 |
Effects of treatment with clofibrate, bezafibrate, and ciprofibrate on the metabolism of cholesterol in rat liver microsomes.
Topics: Animals; Bezafibrate; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Clofibric Acid; Fibric Acids; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase | 1989 |
Effects of long-term administration of clofibric acid on peroxisomal beta-oxidation, fatty acid-binding protein and cytosolic long-chain acyl-CoA hydrolases in rat liver.
Topics: Animals; Carrier Proteins; Cholesterol; Clofibrate; Clofibric Acid; Cytosol; Enzyme Induction; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Liver; Male; Microbodies; Neoplasm Proteins; Nerve Tissue Proteins; Organ Size; Oxidation-Reduction; Palmitoyl Coenzyme A; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Thiolester Hydrolases; Triglycerides | 1985 |
Concomitant increase by peroxisome proliferators of fatty acid-binding protein, peroxisomal beta-oxidation and cytosolic acyl-CoA hydrolase in liver.
Topics: Animals; Carrier Proteins; Cell Division; Clofibrate; Clofibric Acid; Cytosol; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Alcohols; Guinea Pigs; Liver; Male; Mice; Mice, Inbred Strains; Microbodies; Molecular Weight; Neoplasm Proteins; Nerve Tissue Proteins; Oxidation-Reduction; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Thiolester Hydrolases | 1985 |
Induction of altered hepatic foci in rats by the administration of hypolipidemic peroxisome proliferators alone or following a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Clofibrate; Clofibric Acid; Diethylnitrosamine; Drug Administration Schedule; Fibric Acids; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Immunologic Techniques; Liver; Microbodies; Pyrimidines; Rats; Time Factors | 1986 |
Alterations by peroxisome proliferators of acyl composition of hepatic phosphatidylcholine in rats, mice and guinea-pigs. Role of stearoyl-CoA desaturase.
Topics: Acyl Coenzyme A; Acyltransferases; Animals; Clofibrate; Clofibric Acid; Fatty Acid Desaturases; Fatty Alcohols; Guinea Pigs; Liver; Mice; Microbodies; Microsomes, Liver; Palmitoyl Coenzyme A; Phosphatidylcholines; Rats; Rats, Inbred Strains; Species Specificity; Stearoyl-CoA Desaturase | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: histochemical analysis of ciprofibrate-induced preneoplastic and neoplastic lesions for gamma-glutamyl transpeptidase activity.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Histocytochemistry; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1986 |
Experimental pharmacological study of moroxybrate, a hypolipidaemic, antithrombotic, antiatheromatous agent.
Topics: Animals; Anticoagulants; Arteriosclerosis; Clofibrate; Clofibric Acid; Dietary Fats; Fibrinolytic Agents; Hypolipidemic Agents; Lipids; Male; Morpholines; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains | 1987 |
Effects of long-term administration of clofibric acid on stearoyl-CoA desaturase, 1-acylglycerophosphorylcholine acyltransferase and fatty acyl composition of microsomal phosphatidylcholine in rat liver.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acyltransferases; Animals; Clofibrate; Clofibric Acid; Fatty Acid Desaturases; Fatty Acids; Male; Microsomes, Liver; Phosphatidylcholines; Rats; Rats, Inbred Strains; Stearoyl-CoA Desaturase | 1987 |
Differential induction profile of drug-metabolizing enzymes after treatment with hypolipidaemic agents.
Topics: Animals; Biphenyl Compounds; Body Weight; Butyrophenones; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Fenofibrate; gamma-Glutamyltransferase; Glucuronosyltransferase; Hypolipidemic Agents; Lipids; Liver; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1987 |
Effects of clofibric acid and tiadenol on cytosolic long-chain acyl-CoA hydrolase and peroxisomal beta-oxidation in liver and extrahepatic tissues of rats.
Topics: Animals; Brain; Clofibrate; Clofibric Acid; Cytosol; Esterases; Fatty Alcohols; Intestinal Mucosa; Liver; Male; Microbodies; Oxidation-Reduction; Oxidoreductases; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Testis; Thiolester Hydrolases; Tissue Distribution | 1987 |
Absence of gamma-glutamyltranspeptidase activity in lung metastasis in rats with hepatocellular carcinomas induced by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Microbodies; Rats; Rats, Inbred F344 | 1987 |
"The influence of conformational factors on the metabolic conjugation of aryloxyacetates"--a comment.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Clofibrate; Clofibric Acid; Glycine; Glycolates; Molecular Conformation | 1988 |
Induction of peroxisome proliferation and hepatic tumours in C57BL/6N mice by ciprofibrate, a hypolipidaemic compound.
Topics: Adenoma; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Hypolipidemic Agents; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C57BL; Microbodies | 1988 |
The effect of ciprofibrate on gastric secretion in the rat.
Topics: Animals; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Female; Fibric Acids; Gastric Mucosa; Hypolipidemic Agents; Male; Mice; Rats; Rats, Inbred F344; Reference Values | 1988 |
In vivo distribution of a carcinogenic hepatic peroxisome proliferator: whole-body autoradiography of [14C]ciprofibrate in the mouse.
Topics: Administration, Oral; Animals; Autoradiography; Carcinogens; Clofibrate; Clofibric Acid; Fibric Acids; Male; Mice; Time Factors; Tissue Distribution | 1989 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Female; Fibric Acids; Liver; Liver Neoplasms, Experimental; Microbodies; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Immunomodulatory activity of anti-atherogenic drugs: effects on blastogenesis, humoral response, delayed hypersensitivity and passive anaphylaxis by immune complexes.
Topics: Anaphylaxis; Animals; Antibody Formation; Antigen-Antibody Complex; Arteriosclerosis; Clofibrate; Clofibric Acid; Cyclic AMP; Cyclic GMP; Female; Hypersensitivity, Delayed; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Niacin; Thiophenes; Ticlopidine | 1985 |
Fatty acid metabolism in hepatocytes cultured with hypolipidaemic drugs. Role of carnitine.
Topics: Animals; Bezafibrate; Carnitine; Carnitine O-Acetyltransferase; Carnitine O-Palmitoyltransferase; Cells, Cultured; Clofibrate; Clofibric Acid; Fatty Acids; Fibric Acids; Glucagon; Humans; Hypolipidemic Agents; Insulin; Liver; Male; Rats; Rats, Inbred Strains | 1988 |
Gemfibrozil increases both apo A-I and apo E concentrations. Comparison to other lipid regulators in cholesterol-fed rats.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Bezafibrate; Cholesterol, Dietary; Cholesterol, HDL; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Male; Pentanoic Acids; Rats; Rats, Inbred Strains; Valerates | 1986 |
Comparative antiaggregatory activity in human platelets of a benzopyranone aci-reductone, clofibric acid, and a 2,3-dihydrobenzofuran analogue.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Benzofurans; Blood Platelets; Clofibrate; Clofibric Acid; Coumarins; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Structure-Activity Relationship | 1986 |
Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Epoxide Hydrolases; Fibric Acids; Glucuronosyltransferase; Liver Neoplasms, Experimental; Male; Microbodies; Microsomes, Liver; Rats; Rats, Inbred F344; Sulfurtransferases | 1987 |
Comparative study of clofibric acid and bilirubin glucuronidation in human liver microsomes.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Animals; Bilirubin; Clofibrate; Clofibric Acid; Female; Glucuronosyltransferase; Humans; Kinetics; Male; Microsomes, Liver; Middle Aged; Rats; Reference Values; Sex Factors; Smoking | 1987 |
Species variation in gastric toxicity following chronic administration of ciprofibrate to rat, mouse, and marmoset.
Topics: Animals; Callitrichinae; Clofibrate; Clofibric Acid; Fibric Acids; Gastrins; Male; Mice; Rats; Rats, Inbred F344; Species Specificity; Stomach | 1988 |
[Pharmacokinetics of antilipemic agents. 4. Biotransformation of the antilipemic agent ciprofibrate (2-(4-(2,2-dichlorcyclopropyl)-phenoxy)-2-methylpropionic acid)].
Topics: Biotransformation; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Fibric Acids; Humans; Hypolipidemic Agents | 1988 |
Effects of ciprofibrate and 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (POCA) on the distribution of carnitine and CoA and their acyl-esters and on enzyme activities in rats. Relation between hepatic carnitine concentration and carnitine acetyltran
Topics: Acyl Coenzyme A; Animals; Carnitine; Carnitine O-Acetyltransferase; Cells, Cultured; Clofibrate; Clofibric Acid; Coenzyme A; Epoxy Compounds; Ethers, Cyclic; Fibric Acids; Hypoglycemic Agents; Hypolipidemic Agents; Liver; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Studies with etofibrate in the rat. Part I: Effects on glycerol, free fatty acid and triacylglycerol metabolism.
Topics: Adipose Tissue; Animals; Clofibrate; Clofibric Acid; Fatty Acids, Nonesterified; Glycerol; Lipolysis; Lipoproteins, VLDL; Liver; Male; Palmitic Acid; Palmitic Acids; Rats; Rats, Inbred Strains; Triglycerides | 1988 |
Effects of ciprofibrate and fenofibrate on liver lipids and lipoprotein synthesis in normo- and hyperlipidemic rats.
Topics: Animals; Apolipoproteins; Cholesterol; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Hyperlipidemias; Lipids; Lipoproteins; Liver; Male; Propionates; Rats; Rats, Inbred Strains | 1988 |
[Effect of crude drugs and their prescriptions on the blood rheology affected by glucocorticoid treatment. V. Comparison of sho-saiko-to, dai-saiko-to, san-oh-shashin-to and clofibric acid in betamethasone treated rat].
Topics: Animals; Antithrombin III; Betamethasone; Blood Viscosity; Clofibrate; Clofibric Acid; Corticosterone; Drugs, Chinese Herbal; Lipids; Male; Rats | 1988 |
Assessment of gastric antisecretory effects of phenoxyisobutyrate derivatives in the rat and the mouse.
Topics: Administration, Oral; Animals; Bezafibrate; Carcinoid Tumor; Clofibrate; Clofibric Acid; Fibric Acids; Gastric Juice; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Species Specificity; Stomach Neoplasms; Time Factors | 1988 |
Plafibride treatment and serum lipids in hyperlipoproteinemias.
Topics: Adolescent; Adult; Blood Glucose; Cholesterol; Clofibrate; Clofibric Acid; Diet; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Insulin; Male; Phosphatidylcholines; Triglycerides | 1987 |
Pharmacologic treatment of hyperlipidemia reduces glomerular injury in rat 5/6 nephrectomy model of chronic renal failure.
Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Disease Models, Animal; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Hyperlipidemias; Kidney; Kidney Failure, Chronic; Kidney Glomerulus; Lovastatin; Male; Nephrectomy; Nephrons; Rats; Rats, Inbred Strains; Triglycerides | 1988 |
Influence of etofibrate on low density lipoprotein metabolism.
Topics: Adult; Anticholesteremic Agents; Clofibrate; Clofibric Acid; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged | 1988 |
Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes.
Topics: Acyltransferases; Animals; Bezafibrate; Carnitine O-Palmitoyltransferase; Cells, Cultured; Clofibrate; Clofibric Acid; Epoxy Compounds; Ethers, Cyclic; Fatty Acids; Fibric Acids; Isoenzymes; Liver; Male; Rats; Rats, Inbred Strains; Time Factors; Triglycerides | 1988 |
[Amino acid derivatives of 2-(p-chlorophenoxy)-2-methylpropionic acid as compounds with potential antilipemic agents. II. Preparation of methyl esters of N-[2-(p-chlorophenoxy)-2-methylpropionyl] amino acids].
Topics: Amino Acids; Chemical Phenomena; Chemistry; Clofibrate; Clofibric Acid; Humans; Hypolipidemic Agents; Propionates | 1987 |
Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Catalase; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Enoyl-CoA Hydratase; Fibric Acids; Hydro-Lyases; Immunoelectrophoresis; Isomerases; Liver; Male; Microbodies; Multienzyme Complexes; Oxidoreductases; Peroxisomal Bifunctional Enzyme; Rats; Rats, Inbred F344; RNA, Messenger; Transcription, Genetic | 1986 |
Peroxisome proliferator-binding protein: identification and partial characterization of nafenopin-, clofibric acid-, and ciprofibrate-binding proteins from rat liver.
Topics: Animals; Carrier Proteins; Clofibrate; Clofibric Acid; Fibric Acids; Intracellular Signaling Peptides and Proteins; Liver; Male; Molecular Weight; Nafenopin; Propionates; Rats; Rats, Inbred F344 | 1987 |
Induction of peroxisome proliferation in hepatocytes transplanted into the anterior chamber of the eye. A model system for the evaluation of xenobiotic-induced effects.
Topics: Animals; Anterior Chamber; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Fibric Acids; Fluorescent Antibody Technique; Liver; Liver Transplantation; Male; Microbodies; Phthalic Acids; Rats; Rats, Inbred F344 | 1986 |
Concentration of clofibric acid in blood after the administration of delayed-release form of etofibrate.
Topics: Adult; Biotransformation; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Tablets, Enteric-Coated | 1987 |
Serum levels of free non-protein bound clofibrinic acid after single dosing to patients with impaired renal function of various degrees--a multicenter study.
Topics: Adult; Clofibrate; Clofibric Acid; Creatinine; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Protein Binding; Serum Albumin | 1987 |
Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl)phthalate on hepatic enzyme activities and lipid peroxidation in the rat.
Topics: Animals; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Hepatomegaly; Lipid Peroxides; Liver; Male; Microbodies; Phthalic Acids; Rats; Rats, Inbred Strains | 1987 |
Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats.
Topics: Adipose Tissue; Animals; Cholesterol; Clofibrate; Clofibric Acid; Lipid Metabolism; Lipids; Liver; Male; Obesity; Rats; Rats, Zucker; Time Factors | 1987 |
[Etofibrate in severe diet-refractory cases of hyperlipoproteinemia].
Topics: Adult; Aged; Cholesterol; Clofibrate; Clofibric Acid; Dietary Fats; Female; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 1986 |
Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate.
Topics: Animals; Bile; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Glutathione Transferase; Hypolipidemic Agents; Liver; Male; Microbodies; Rats; Rats, Inbred Strains; Sulfobromophthalein | 1986 |
Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
Topics: Adipates; Animals; Catalase; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Fibric Acids; Liver; Liver Neoplasms, Experimental; Microbodies; Microscopy, Electron; Oxidation-Reduction; Phthalic Acids; Rats; Structure-Activity Relationship | 1986 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Precancerous Conditions; Pyrimidines; Rats; Rats, Inbred F344 | 1986 |
Effect of cholesterol and alpha-p-chlorophenoxyisobutyrate passage on virulence in Acanthamoeba culbertsoni strain A-1 and C-7.
Topics: Amoeba; Animals; Cholesterol; Clofibrate; Clofibric Acid; Virulence | 1986 |
Separation and measurement of clofibroyl coenzyme A and clofibric acid in rat liver after clofibrate adminstration by reversed-phase high-performance liquid chromatography with photodiode array detection.
Topics: Acyl Coenzyme A; Animals; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Liver; Male; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1986 |
Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.
Topics: Acyl Coenzyme A; Animals; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Coenzyme A Ligases; Fibric Acids; Hydrolysis; Male; Microsomes, Liver; Nafenopin; Propionates; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Spectrophotometry, Ultraviolet | 1986 |
Beclobrinic acid--a new hypolipidemic agent--inhibits in vitro human platelet activation by blocking prostaglandin synthesis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Benzhydryl Compounds; Blood Platelets; Clofibrate; Clofibric Acid; Humans; Hypolipidemic Agents; In Vitro Techniques; Malondialdehyde; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Serotonin | 1985 |
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Benzphetamine; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Fibric Acids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Lauric Acids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1985 |
The effect of three hypolipidemic drugs on catalase activity and peroxisomal and mitochondrial palmitate oxidation in rat cardiac and skeletal muscle.
Topics: Animals; Body Weight; Catalase; Clofibrate; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Male; Microbodies; Mitochondria, Heart; Mitochondria, Muscle; Muscles; Myocardium; Nafenopin; Oxidation-Reduction; Palmitates; Palmitic Acids; Rats; Rats, Inbred Strains | 1986 |
Effect of etofibrate and its metabolites on atheromas of rabbits and on smooth muscle cell cultures.
Topics: Animals; Anticholesteremic Agents; Aorta; Arteriosclerosis; Carotid Arteries; Cell Division; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Clofibrate; Clofibric Acid; Clone Cells; Electric Stimulation; Fibroblasts; Lipoproteins, HDL; Male; Muscle, Smooth, Vascular; Rabbits; Triglycerides | 1986 |
Underestimation of albumin content by bromocresol green, induced by drug displacers and uremia.
Topics: Adult; Bromcresol Green; Clofibrate; Clofibric Acid; Cresols; Electrophoresis, Cellulose Acetate; Humans; Phenylbutazone; Protein Binding; Serum Albumin; Uremia | 1985 |
[Plafibride and vascular insufficiency of the lower limbs].
Topics: Clofibrate; Clofibric Acid; Drug Evaluation; Humans; Intermittent Claudication | 1985 |
[Plafibride--is it an effective drug as a hypolipemic agent?].
Topics: Clofibrate; Clofibric Acid; Drug Evaluation; Humans; Hypolipidemic Agents; Intermittent Claudication | 1985 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; DNA; Fibric Acids; Hypolipidemic Agents; In Vitro Techniques; Liver; Liver Neoplasms; Male; Microbodies; Phosphorus Radioisotopes; Pyrimidines; Rats | 1985 |
Disposition of etofibrate, clofibric and nicotinic acid esters, and their products in dogs.
Topics: Animals; Clofibrate; Clofibric Acid; Dogs; Esters; Half-Life; Hypolipidemic Agents; Injections, Intravenous; Kinetics; Male; Niacin; Solubility; Solvents; Time Factors | 1985 |
Induction of peroxisomal beta-oxidation enzymes in primary cultured rat hepatocytes by clofibric acid.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyltransferases; Acyl-CoA Oxidase; Animals; Catalase; Cells, Cultured; Clofibrate; Clofibric Acid; Enoyl-CoA Hydratase; Enzyme Induction; Fatty Acids; Liver; Microbodies; Oxidation-Reduction; Oxidoreductases; Rats; RNA, Messenger | 1985 |
Bioavailability studies of etofibrate in rhesus monkeys.
Topics: Animals; Biological Availability; Clofibrate; Clofibric Acid; Drug Interactions; Female; Half-Life; Hypolipidemic Agents; Intestinal Absorption; Macaca mulatta; Niacin; Time Factors | 1985 |
Effect of clofibric acid and tiadenol on peroxisomal beta-oxidation and fatty acid binding protein in intestinal mucosa of rats.
Topics: Administration, Oral; Animals; Catalase; Clofibrate; Clofibric Acid; Electrophoresis, Polyacrylamide Gel; Fatty Alcohols; Intestinal Mucosa; Liver; Male; Oleic Acid; Oleic Acids; Oxidation-Reduction; Palmitoyl Coenzyme A; Protein Binding; Rats; Rats, Inbred Strains | 1985 |
Mitochondrial myopathy--a result of clofibrate/etofibrate treatment? Case report.
Topics: Aged; Clofibrate; Clofibric Acid; Humans; Hypolipidemic Agents; Kearns-Sayre Syndrome; Male; Microscopy, Electron; Mitochondria, Muscle; Muscles; Muscular Diseases | 1985 |
Effect of Ciprofibrate on platelet aggregation and fibrinolysis in patients with hypercholesterolaemia.
Topics: Adult; Alkaline Phosphatase; Cholesterol; Clofibrate; Clofibric Acid; Fibric Acids; Fibrinogen; Fibrinolysis; Humans; Hypercholesterolemia; Male; Middle Aged; Platelet Aggregation; Platelet Count | 1985 |
[Hypolipemic effect of amino acid derivatives of clofibric acid].
Topics: Animals; Clofibrate; Clofibric Acid; Drug Evaluation, Preclinical; Hypolipidemic Agents; Male; Rats; Rats, Inbred Strains | 1985 |
Long-term treatment of hyperlipoproteinemia with etofibrate: clinical observations.
Topics: Adult; Aged; Cholesterol; Clofibrate; Clofibric Acid; Creatine Kinase; Female; gamma-Glutamyltransferase; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Long-Term Care; Male; Middle Aged; Triglycerides; Uric Acid | 1980 |
Effect of clofibric acid administration on palmitoyl-CoA hydrolase activity in rat liver.
Topics: Animals; Clofibrate; Clofibric Acid; Cytosol; Female; Liver; Microsomes, Liver; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Thiolester Hydrolases | 1981 |
Sex-related difference in the effect of clofibric acid on induction of two novel long-chain acyl-CoA hydrolases in rat liver.
Topics: Animals; Clofibrate; Clofibric Acid; Cytosol; Enzyme Induction; Female; Kinetics; Liver; Male; Microsomes, Liver; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Sex Factors; Subcellular Fractions; Thiolester Hydrolases | 1982 |
Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid.
Topics: Acyl Coenzyme A; Animals; Clofibrate; Clofibric Acid; Diabetes Mellitus, Experimental; Fatty Acid Desaturases; Female; Hyperthyroidism; Hypothyroidism; Kinetics; Male; Microsomes, Liver; Oleic Acid; Oleic Acids; Rats; Sex Factors; Stearoyl-CoA Desaturase | 1982 |
Induction of hepatic long-chain acyl-CoA hydrolase by clofibric acid administration.
Topics: Animals; Clofibrate; Clofibric Acid; Cytosol; Enzyme Induction; Female; Guinea Pigs; Liver; Male; Mice; Mice, Inbred Strains; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Species Specificity; Thiolester Hydrolases | 1983 |
Differential effects of altered hormonal state on the induction of acyl-CoA hydrolases and peroxisomal beta-oxidation by clofibric acid.
Topics: Adrenalectomy; Animals; Clofibrate; Clofibric Acid; Dexamethasone; Diabetes Mellitus, Experimental; Fatty Acids; Hepatomegaly; Hyperthyroidism; Hypothyroidism; Insulin; Liver; Male; Microbodies; Organoids; Oxidation-Reduction; Palmitoyl-CoA Hydrolase; Rats; Thiolester Hydrolases | 1983 |
Induction and origin of hepatocytes in rat pancreas.
Topics: Animals; Clofibrate; Clofibric Acid; Fibric Acids; Hypolipidemic Agents; Liver; Male; Microscopy, Electron; Organ Specificity; Pancreas; Rats; Rats, Inbred F344; Staining and Labeling | 1984 |
Influence of plafibride, an antiplatelet and hypolipemic agent, on prostacyclin and thromboxane synthesis, 3',5'-cyclic AMP phosphodiesterase activity and serum clearance of a lipid emulsion.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cattle; Clofibrate; Clofibric Acid; Cyclooxygenase Inhibitors; Depression, Chemical; Epoprostenol; Fat Emulsions, Intravenous; Hypolipidemic Agents; In Vitro Techniques; Kinetics; Lipids; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxanes | 1981 |
Effects of bezafibrate on receptor-mediated and receptor-independent low density lipoprotein catabolism in type II hyperlipoproteinaemic subjects.
Topics: Adult; Apolipoproteins; Apolipoproteins B; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type II; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Receptors, Cell Surface; Receptors, LDL | 1982 |
Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat.
Topics: Aging; Animals; Animals, Newborn; Clofibrate; Clofibric Acid; Digitonin; Enzyme Activation; Enzyme Induction; Female; Fetus; Glucuronosyltransferase; Male; Microsomes, Liver; Pregnancy; Rats | 1983 |
Effect of ciprofibrate treatment on biliary lipids in patients with hyperlipoproteinaemia.
Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholesterol; Clofibrate; Clofibric Acid; Female; Fibric Acids; Humans; Hyperlipoproteinemias; Lipids; Male; Middle Aged; Phospholipids; Triglycerides | 1984 |
[Evaluation of the effects of plafibride and lysine acetyl salicylate on the production of PGI2].
Topics: Animals; Aorta; Arteriosclerosis; Aspirin; Clofibrate; Clofibric Acid; Diet, Atherogenic; Epoprostenol; Lysine; Male; Platelet Aggregation; Rabbits | 1983 |
The effect of peroxisome proliferators on the metabolism and spectral interaction of endogenous substrates of cytochrome P-450 in rat hepatic microsomes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Diethylhexyl Phthalate; Hydroxylation; Linoleic Acid; Linoleic Acids; Male; Microbodies; Microsomes, Liver; Phthalic Acids; Rats; Rats, Inbred Strains; Testosterone | 1984 |
Modification by clofibric acid of acyl composition of glycerolipids in rat liver. Possible involvement of fatty acid chain elongation and desaturation.
Topics: Acyl Coenzyme A; Acylation; Animals; Carbon Radioisotopes; Clofibrate; Clofibric Acid; Fatty Acids; Fatty Acids, Nonesterified; Glycerides; Kinetics; Liver; Male; Microsomes, Liver; Phospholipids; Rats; Rats, Inbred Strains | 1984 |
Irreversible inhibition of hepatic glutathione S-transferase by ciprofibrate, a peroxisome proliferator.
Topics: Animals; Clofibrate; Clofibric Acid; Ethoxyquin; Fibric Acids; Glutathione Transferase; Kinetics; Liver; Macromolecular Substances; Male; Microbodies; Rats; Rats, Inbred F344 | 1984 |
Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination.
Topics: Adult; Clofibrate; Clofibric Acid; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Female; Glucuronates; Humans; Kinetics; Male; Metabolic Clearance Rate; Sex Factors | 1984 |
[Pharmacologic therapy of arteriosclerosis: current possibilities].
Topics: Anticholesteremic Agents; Arteriosclerosis; Clofibrate; Clofibric Acid; Humans | 1984 |
Effect of hyperbilirubinaemia on the plasma protein binding of chlorophenoxyisobutyric acid in neonates.
Topics: Bilirubin; Blood Proteins; Clofibrate; Clofibric Acid; Humans; Infant, Newborn; Jaundice, Neonatal; Kinetics | 1984 |
[Therapy of vascular insufficiency of the legs with plafibride].
Topics: Adult; Aged; Clofibrate; Clofibric Acid; Drug Tolerance; Humans; Hypolipidemic Agents; Intermittent Claudication; Leg; Male; Middle Aged | 1984 |
Relative bioavailability of etofibrate. A comparison of an acute and a new sustained release formulation.
Topics: Adult; Biological Availability; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Humans; Hypolipidemic Agents; Kinetics; Male | 1984 |
Dose-dependent pharmacokinetics of clofibric acid in the non-human primate.
Topics: Animals; Biological Availability; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Kinetics; Macaca fascicularis; Papio; Protein Binding | 1984 |
[Atherosclerosis treatment with etofibrate retard. New perspectives].
Topics: Arteriosclerosis; Blood Glucose; Cholesterol; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Female; Hemodynamics; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Triglycerides; Uric Acid | 1983 |
Plasmolysis, red blood cell partitioning, and plasma protein binding of etofibrate, clofibrate, and their degradation products.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Dogs; Erythrocytes; Humans; Hydrolysis; In Vitro Techniques; Plasma; Protein Binding; Ultrafiltration | 1983 |
Detection of a nafenopin-binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds.
Topics: Animals; Carrier Proteins; Clofibrate; Clofibric Acid; Cytosol; Enzyme Induction; Fibric Acids; Kidney Cortex; Liver; Male; Microbodies; Nafenopin; Propionates; Rats; Rats, Inbred F344 | 1983 |
Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle.
Topics: Acute Kidney Injury; Animals; Carbon Radioisotopes; Clofibrate; Clofibric Acid; Creatinine; Glucuronates; Kidney; Male; Rabbits; Time Factors; Uranyl Nitrate | 1983 |
A renal mechanism for the clofibric acid-probenecid interaction.
Topics: Animals; Clofibrate; Clofibric Acid; Drug Interactions; Glucuronates; Hydrolysis; Kidney; Probenecid; Rabbits; Time Factors | 1983 |
The analysis of [14C]clofibric acid glucuronide and [14C]clofibric acid in plasma and urine using high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Drug Stability; Half-Life; Hydrolysis; Male; Rabbits; Rats; Rats, Inbred Strains | 1983 |
Hypolipemic profile of plafibride in a model of experimental atherosclerosis.
Topics: Animals; Arteriosclerosis; Cholesterol; Cholesterol, HDL; Clofibrate; Clofibric Acid; Female; Hypolipidemic Agents; Lipoproteins, HDL; Rats; Rats, Inbred Strains; Triglycerides | 1983 |
Favorable effects of the lipid-lowering and platelet antiaggregant Plafibride on the aging process of mice of the C57bl/6J strain.
Topics: Aging; Animal Feed; Animals; Body Weight; Clofibrate; Clofibric Acid; Hypolipidemic Agents; Lipofuscin; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; Platelet Aggregation | 1983 |
Activity of plafibride on erythrocyte deformability.
Topics: Adult; Animals; Clofibrate; Clofibric Acid; Dogs; Erythrocytes; Female; Humans; In Vitro Techniques; Male; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Endogenous ligand(s) decrease drug--protein binding in uremic sera: a fluorescence probe study.
Topics: Adult; Clofibrate; Clofibric Acid; Dansyl Compounds; Female; Fluorescent Dyes; Glycine; Humans; Kidney Failure, Chronic; Ligands; Male; Middle Aged; Protein Binding; Serum Albumin; Software; Spectrometry, Fluorescence; Uremia | 1983 |
Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.
Topics: Animals; Anisoles; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Clofibric Acid; Drug Antagonism; Ethoxyquin; Fibric Acids; Hypolipidemic Agents; Liver Neoplasms; Male; Microbodies; Quinolines; Rats; Rats, Inbred F344 | 1984 |
Influence of food on the absorption of the p-chlorophenolic ester of chlorophenoxyisobutyric acid in man.
Topics: Adult; Clofibrate; Clofibric Acid; Fasting; Female; Food; Humans; Intestinal Absorption; Kinetics; Male | 1984 |
Selective increase in acylation of 1-acylglycerophosphorylcholine in livers of rats and mice by peroxisome proliferators.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acylation; Acyltransferases; Animals; Aspirin; Clofibrate; Clofibric Acid; Fatty Alcohols; Glycerylphosphorylcholine; Guinea Pigs; Hypolipidemic Agents; Liver; Lysophosphatidylcholines; Male; Mice; Microbodies; Microsomes, Liver; Rats; Rats, Inbred Strains | 1984 |
Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart.
Topics: Acetates; Animals; Clofibrate; Clofibric Acid; Dichloroacetic Acid; Enzyme Activation; In Vitro Techniques; Male; Myocardium; Perfusion; Phenylpyruvic Acids; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Rats; Rats, Inbred Strains | 1984 |
[Plafibride treatment of hyperlipidemias type II and IV].
Topics: Adult; Cholesterol; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 1984 |
Diisopropylfluorophosphate increases clofibric acid clearance: supporting evidence for a futile cycle.
Topics: Anesthesia; Animals; Blood Pressure; Clofibrate; Clofibric Acid; Hydrolysis; Isoflurophate; Male; Metabolic Clearance Rate; Models, Biological; Rabbits | 1984 |
[Improvement in diabetes control by treatment with bezafibrate].
Topics: Aged; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hyperlipidemias; Insulin; Male; Sulfonylurea Compounds; Triglycerides | 1982 |
[Longterm therapy and etofibrate (author's transl)].
Topics: Anticholesteremic Agents; Blood Cell Count; Blood Glucose; Clofibrate; Clofibric Acid; Drug Administration Schedule; Drug Tolerance; Humans; Hyperlipoproteinemias; Triglycerides | 1980 |
Reduced LDL- and increased HDL-apoproteins in patients with hypercholesterolaemia under treatment with bezafibrate.
Topics: Adult; Aged; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins; Apolipoproteins B; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibrate; Clofibric Acid; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Triglycerides | 1981 |
Synthesis and pharmacological evaluation of N'-morpholinomethylurea derivatives with platelet antiaggregant activity.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Chemical Phenomena; Chemistry; Clofibrate; Clofibric Acid; Humans; Hypolipidemic Agents; In Vitro Techniques; Lethal Dose 50; Platelet Aggregation; Rats; Rats, Inbred Strains | 1981 |
Platelet antiaggregant activity of plafibride ex vivo in rat, dog and rabbit.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Clofibrate; Clofibric Acid; Collagen; Dogs; Epinephrine; Female; In Vitro Techniques; Male; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1981 |
[Effect of combination therapy of clofibric acid and nicotinic acid derivatives on fatty acid metabolism in hyperlipoproteinemia].
Topics: Aged; Clofibrate; Clofibric Acid; Drug Therapy, Combination; Fatty Acids; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Long-Term Care; Male; Middle Aged; Nicotinic Acids | 1982 |
[Bezafibrate and delayed action etofibrate in hyperlipidemia].
Topics: Bezafibrate; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Humans; Hyperlipidemias; Lipoproteins, HDL; Lipoproteins, LDL; Triglycerides | 1983 |
The effect of bezafibrate and clofibrate on cholesterol ester metabolism in rabbit peritoneal macrophages stimulated with acetylated low density lipoproteins.
Topics: Animals; Ascitic Fluid; Bezafibrate; Cholesterol Esters; Clofibrate; Clofibric Acid; Lipoproteins, LDL; Macrophages; Rabbits; Sterol Esterase; Sterol O-Acyltransferase | 1983 |
Relationship between morphological changes and lipid-lowering action of p-chlorphenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man.
Topics: Adult; Aged; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemias; Male; Microbodies; Microscopy, Electron; Middle Aged; Mitochondria, Liver; Organoids | 1983 |
Elevation of high density lipoprotein cholesterol (cHDL) and reduction of the total cholesterol/cHDL index in the treatment of hyperlipoproteinaemias IIb and IV with bezafibrate.
Topics: Adult; Aged; Bezafibrate; Cholesterol; Cholesterol, HDL; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipoproteins, HDL; Male; Middle Aged; Triglycerides | 1983 |
Dose-response study of the effect of ciprofibrate on serum lipoprotein concentrations in hyperlipoproteinaemia.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Sedimentation; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Fibric Acids; Follow-Up Studies; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Triglycerides | 1982 |
The short- and long-term effects of bezafibrate in the rat.
Topics: Animals; Bezafibrate; Carnitine O-Acetyltransferase; Catalase; Cholesterol; Clofibrate; Clofibric Acid; Female; Hypolipidemic Agents; Kinetics; Liver; Male; Microbodies; Microscopy, Electron; Organ Size; Organoids; Rats; Rats, Inbred Strains; Triglycerides | 1982 |
Pharmacological activities and side effects of plafibride.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nervous System; Body Temperature; Cardiovascular System; Central Nervous System; Clofibrate; Clofibric Acid; Digestive System; Dogs; Female; Guinea Pigs; Male; Mice; Peripheral Nerves; Rabbits; Rats; Respiration | 1981 |
Effects of bezafibrate on the serum lipoprotein lipid and apolipoprotein composition, lipoprotein triglyceride removal capacity and the fatty acid composition of the plasma lipid esters.
Topics: Adult; Apolipoproteins; Bezafibrate; Blood Glucose; Body Weight; Cholesterol; Clofibrate; Clofibric Acid; Esters; Fatty Acids; Female; Humans; Insulin; Lipids; Lipoproteins; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Triglycerides | 1980 |
Effects of etofibrate on platelet function: in vitro studies in human plasma.
Topics: Animals; Blood Platelets; Clofibrate; Clofibric Acid; Epoprostenol; Humans; Male; Malondialdehyde; Nicotinic Acids; Platelet Factor 3; Rats; Serotonin | 1980 |
Stimulation of anti-aggregatory activity from rat aorta by hypolipidemic drugs.
Topics: Animals; Aorta; Cattle; Clofibrate; Clofibric Acid; Epoprostenol; Humans; Hydrogen-Ion Concentration; Lipids; Male; Nicotinic Acids; Pentoxifylline; Platelet Aggregation; Rats | 1980 |
Bacterial mutation test on plafibride.
Topics: Animals; Clofibrate; Clofibric Acid; In Vitro Techniques; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium | 1981 |
Predictions of stability in pharmaceutical preparations XIX: Stability evaluation and bioanalysis of clofibric acid esters by high-pressure liquid chromatography.
Topics: Animals; Buffers; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Dogs; Drug Stability; Humans; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Kinetics; Models, Chemical | 1982 |
[Lowering lipids rapidly and permanently with etofibrate].
Topics: Cholestyramine Resin; Clofibrate; Clofibric Acid; Dextrothyroxine; Humans; Hyperlipoproteinemias; Lipoproteins, HDL; Liver; Nicotinic Acids; Sitosterols | 1982 |
The effect of bezafibrate and clofibrate on cholesterol ester metabolism in 3T3 cells in smooth muscle cells in tissue culture.
Topics: Animals; Aorta; Bezafibrate; Cell Line; Cholesterol; Cholesterol Esters; Clofibrate; Clofibric Acid; Culture Techniques; Lipoproteins, LDL; Mice; Muscle, Smooth, Vascular; Swine | 1982 |
Determination of ciprofibrate in human plasma by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Computers; Fibric Acids; Humans; Rats; Reference Values | 1982 |
[Bezafibrate in primary hyperlipidemias (author's transl)].
Topics: Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipidemias; Hyperlipoproteinemias; Lipoprotein Lipase; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged | 1982 |
Effects of bezafibrate on the composition of very low density lipoproteins in type IV hyperlipoproteinemia.
Topics: Apolipoprotein C-I; Apolipoprotein C-II; Apolipoproteins; Apolipoproteins C; Apolipoproteins E; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipoproteins, VLDL; Male; Protein Conformation; Triglycerides | 1982 |
Specificity in the action of hypolipidemic drugs: increase of peroxisomal beta-oxidation largely dissociated from hepatomegaly and peroxisome proliferation in the rat.
Topics: Animals; Bezafibrate; Cell Division; Cell Fractionation; Clofibrate; Clofibric Acid; Female; Hepatomegaly; Hypolipidemic Agents; Male; Microbodies; Organ Size; Organoids; Rats; Rats, Inbred F344; Sex Factors | 1982 |
Bezafibrate: lack of effect on creatinine excretion and muscular proteins.
Topics: Bezafibrate; Clofibrate; Clofibric Acid; Creatine Kinase; Creatinine; Female; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Isoenzymes; Kidney; Male; Middle Aged; Muscle Proteins; Muscles; Myoglobinuria | 1982 |
[Study of the binding characteristics of chlorophenoxyisobutyric acid to serum proteins in chronically uremic patients : influence of dialysis and heparine (author's transl)].
Topics: Binding, Competitive; Blood Proteins; Clofibrate; Clofibric Acid; Dialysis; Heparin; Humans; In Vitro Techniques; Kidney Failure, Chronic; Protein Binding; Renal Dialysis | 1982 |
Experience with probucol in the treatment of hypercholesterolemia.
Topics: Cholesterol; Clofibrate; Clofibric Acid; Humans; Hypercholesterolemia; Lipoproteins; Male; Middle Aged; Patient Compliance; Phenols; Probucol | 1982 |
[Single-blind study of the efficacy of pirozadil versus alufibrate in the treatment of primary hyperlipoproteinemias].
Topics: Cholesterol; Clofibrate; Clofibric Acid; Drug Evaluation; Female; Humans; Hyperlipoproteinemias; Lipoproteins; Male; Middle Aged; Platelet Aggregation; Pyridines; Random Allocation | 1982 |
Elevated lipoprotein lipase activity in skeletal muscle tissue during treatment of hypertriglyceridaemic patients with bezafibrate.
Topics: Adipose Tissue; Adult; Bezafibrate; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipoprotein Lipase; Male; Middle Aged; Muscles | 1982 |
[Fat and renal failure--therapeutic aspects].
Topics: Acute Kidney Injury; Animals; Bezafibrate; Carnitine; Charcoal; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Infusions, Parenteral; Kidney Failure, Chronic; Lipids; Physical Exertion; Rats; Renal Dialysis | 1982 |
[Lipid lowering improved? Therapeutic progress by using biological mechanisms].
Topics: Anticholesteremic Agents; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemia Type II | 1982 |
[Current treatment with clofibrate or clofibric acid (Regadrin)].
Topics: Cholelithiasis; Cholesterol; Clofibrate; Clofibric Acid; Humans; Hypercholesterolemia; Hyperlipoproteinemias; Triglycerides | 1982 |
Treatment of uremic hypertriglyceridaemia with bezafibrate.
Topics: Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipidemias; Kidney Failure, Chronic; Lipid Metabolism; Lipoproteins; Male; Triglycerides | 1982 |
Bezafibrate treatment in primary hypercholesterolaemia. Possibility of intermittent treatment.
Topics: Animals; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibrate; Clofibric Acid; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, LDL; Mice; Microbodies; Rats; Time Factors | 1982 |
[Treatment of coronary heart disease with diet and lipid-reducing agents].
Topics: Adolescent; Adult; Child; Cholestyramine Resin; Clofibrate; Clofibric Acid; Colestipol; Coronary Disease; Dextrothyroxine; Humans; Hypolipidemic Agents; Nicotinic Acids; Risk | 1982 |
The effect of bezafibrate and clofibrate on microsomal ACAT and lysosomal cholesterol ester hydrolase activity in the cholesterol-fed rabbit aorta.
Topics: Acyltransferases; Animals; Aorta; Bezafibrate; Carboxylic Ester Hydrolases; Clofibrate; Clofibric Acid; Female; Hypolipidemic Agents; Lysosomes; Rabbits; Regression Analysis; Sterol Esterase; Sterol O-Acyltransferase | 1982 |
[Effect of clofibric acid on fatty acid metabolism in HLP patients in the 2d half of life].
Topics: Adult; Aged; Cholesterol Esters; Clofibrate; Clofibric Acid; Fatty Acids; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Male; Middle Aged; Triglycerides | 1982 |
[Effect of bezafibrate on lipid and apoprotein levels in patients with idiopathic hypertriglyceridemia].
Topics: Adult; Aged; Apolipoproteins; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type III; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Male; Middle Aged; Triglycerides | 1982 |
[What is important in therapy of hyperlipoproteinemia. Lipo-Merz retard (etofibrate) lowers the atherogenic index].
Topics: Anticholesteremic Agents; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Humans; Hyperlipoproteinemias | 1982 |
[Stability of antilipidemic etofibrate and its metabolites towards gastrointestinal and blood hydrolases (author's transl)].
Topics: Biotransformation; Clofibrate; Clofibric Acid; Digestive System; Drug Stability; Esterases; Humans; Hydrolases; Hypolipidemic Agents; Kinetics | 1980 |
Plafibride (ITA 104).
Topics: Clofibrate; Clofibric Acid; Humans | 1981 |
Physico-chemical and analytical studies on plafibride.
Topics: Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clofibrate; Clofibric Acid; Drug Stability; Magnetic Resonance Spectroscopy; Mass Spectrometry; Potentiometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1981 |
Hypolipemic activity of plafibride.
Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Dogs; Fatty Acids, Nonesterified; Hypolipidemic Agents; Lipoproteins; Male; Mice; Mice, Inbred Strains; Polyethylene Glycols; Rats; Rats, Inbred Strains; Triglycerides | 1981 |
Pharmacokinetic approach of plafibride in rat.
Topics: Animals; Clofibrate; Clofibric Acid; Feces; Hypolipidemic Agents; Kinetics; Male; Protein Binding; Rats; Rats, Inbred Strains | 1981 |
Toxicological studies of plafibride. Part 1: Acute toxicity and its determination after several administrations of plafibride.
Topics: Administration, Oral; Animals; Clofibrate; Clofibric Acid; Cricetinae; Female; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Species Specificity | 1981 |
Toxicological studies of plafibride. Part 2: Subacute and subchronic toxicity in rats and chronic toxicity in dogs.
Topics: Animals; Blood Cell Count; Body Weight; Clofibrate; Clofibric Acid; Dogs; Female; Male; Organ Size; Rats; Rats, Inbred Strains; Species Specificity; Time Factors | 1981 |
Toxicological studies of plafibride. Part 3: Study of teratogenic activity in rats and rabbits.
Topics: Animals; Clofibrate; Clofibric Acid; Female; Fetus; Pregnancy; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Teratogens | 1981 |
Toxicological studies of plafibride. Part 4: Interaction of plafibride with other drugs.
Topics: Animals; Blepharoptosis; Blood Pressure; Body Temperature; Clofibrate; Clofibric Acid; Dogs; Drug Interactions; Mice; Rats; Rats, Inbred Strains; Reserpine; Warfarin | 1981 |
Bioavailability of plafibride in healthy volunteers.
Topics: Adult; Biological Availability; Clofibrate; Clofibric Acid; Female; Humans; Male; Platelet Aggregation | 1981 |
[Effect of bezafibrate on the carbohydrate metabolism of 17 diabetics with hyperlipidemia].
Topics: Anticholesteremic Agents; Bezafibrate; Body Weight; Carbohydrate Metabolism; Clofibrate; Clofibric Acid; Diabetes Complications; Humans; Hyperlipidemias; Placebos | 1981 |
"In vitro" metabolism of bezafibrate by rat liver.
Topics: Animals; Bezafibrate; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Hydroxylation; Hypolipidemic Agents; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Rats; Subcellular Fractions | 1981 |
[Etofibrate lowers the atherosclerosis index].
Topics: Arteriosclerosis; Clofibrate; Clofibric Acid; Humans; Lipids | 1981 |
Effect of bezafibrate on the high-density lipoprotein subfractions HDL2 and HDL3 in primary hyperlipoproteinemia type IV.
Topics: Adult; Apolipoproteins; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemia Type IV; Lipids; Lipoproteins, HDL; Male; Middle Aged; Triglycerides | 1980 |
Glucuronic acid conjugates of clofibrate: four isomeric structures.
Topics: Clofibrate; Clofibric Acid; Humans; Isomerism | 1981 |
The simultaneous analysis of clofibric acid and probenecid and the direct analysis of clofibric acid glucuronide by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Glucuronates; Glucuronidase; Humans; Probenecid | 1981 |
Lipids and lipoproteins in hyperlipidemia type IIa during treatment with different lipid lowering drugs.
Topics: Adolescent; Bezafibrate; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type II; Inositol; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Male; Nicotinic Acids; Nicotinyl Alcohol; Xanthinol Niacinate | 1980 |
Clinical experience with bezafibrate.
Topics: Bezafibrate; Blood Glucose; Body Weight; Cholesterol; Clofibrate; Clofibric Acid; Coronary Disease; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Male; Triglycerides | 1980 |
Effects of clofibric acid and bezafibrate administration on activities of alkaline phosphatase and other enzymes in livers of rats.
Topics: Alkaline Phosphatase; Animals; Bezafibrate; Bilirubin; Clofibrate; Clofibric Acid; Glucuronates; Glucuronosyltransferase; Hexosyltransferases; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Rats; Rats, Inbred Strains | 1981 |
[Rhabdomyolysis with acute renal failure due to bezafibrate].
Topics: Acute Kidney Injury; Bezafibrate; Clofibrate; Clofibric Acid; Humans; Male; Middle Aged; Muscular Diseases | 1981 |
Effects of bezafibrate on low HDL-cholesterol in patients with ischaemic cerebrovascular disease: a pilot study.
Topics: Adult; Bezafibrate; Cerebral Infarction; Cholesterol; Cholesterol, HDL; Clofibrate; Clofibric Acid; Humans; Hypolipidemic Agents; Ischemic Attack, Transient; Lipoproteins, HDL; Male; Middle Aged | 1981 |
[Toxicological and pharmacological studies on a new drug: pirfibrate (EL-466) (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Clofibrate; Clofibric Acid; Diet, Atherogenic; Dogs; Female; Fertility; Hyperlipidemias; Hypolipidemic Agents; Lethal Dose 50; Lipids; Male; Mice; Pregnancy; Propionates; Pyridinolcarbamate; Rabbits; Rats | 1980 |
Acute muscular syndrome after bezafibrate.
Topics: Bezafibrate; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Humans; Hypolipidemic Agents; Myoglobinuria | 1981 |
Effects of drug binding on the esterase-like activity of human serum albumin. III. Evaluation of reactivities of the two active sites by using clofibric acid as an inhibitor.
Topics: Binding Sites; Clofibrate; Clofibric Acid; Esterases; Humans; Protein Binding; Serum Albumin | 1981 |
Clinical pharmacokinetics of bezafibrate in patients with impaired renal function.
Topics: Adult; Aged; Bezafibrate; Clofibrate; Clofibric Acid; Creatinine; Female; Humans; Hyperlipidemias; Hypolipidemic Agents; Kidney Failure, Chronic; Kinetics; Male; Middle Aged | 1981 |
Comparative pharmacokinetics of 400 mg bezafibrate after a single oral administration of a new slow-release preparation and the currently available commercial form.
Topics: Administration, Oral; Adolescent; Adult; Bezafibrate; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Female; Humans; Hypolipidemic Agents; Kinetics; Male | 1981 |
Induction of acyl-CoA dehydrogenases and electron transfer flavoprotein and their roles in fatty acid oxidation in rat liver mitochondria.
Topics: Animals; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Enzyme Induction; Fatty Acid Desaturases; Fatty Acids; Flavoproteins; Microbodies; Mitochondria, Liver; Phthalic Acids; Rats | 1981 |
Effect of the hypolipidemic drug bezafibrate on the hepatic mixed function oxidase system of the rat: heterogeneity monooxygenase responses.
Topics: Animals; Bezafibrate; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Hypolipidemic Agents; Liver; Male; Mixed Function Oxygenases; Oxidoreductases; Rats; Rats, Inbred Strains; Spectrum Analysis | 1981 |
Saliva and plasma levels and plasma protein binding of clofibrinic acid in uremic patients.
Topics: Adult; Aged; Blood Proteins; Clofibrate; Clofibric Acid; Humans; Kidney Failure, Chronic; Middle Aged; Protein Binding; Renal Dialysis; Saliva; Uremia | 1980 |
Simultaneous GLC determination of clofibrate and clofibric acid in human plasma.
Topics: Chromatography, Gas; Clofibrate; Clofibric Acid; Humans; Hydrolysis | 1980 |
[Bile lipid composition in subjects with blood lipid disorders (types II and IV). Effect of a new hypolipemic drug (Etofibrate)].
Topics: Adult; Aged; Bile; Clofibrate; Clofibric Acid; Female; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Lipids; Male; Middle Aged | 1980 |
Branched chain amino acid oxidation in cultured rat skeletal muscle cells. Selective inhibition by clofibric acid.
Topics: Amino Acids, Branched-Chain; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Kinetics; Leucine; Muscles; Oxidation-Reduction; Rats | 1980 |
Effects of p-chlorophenoxyisobutyric acid (CPIB) on the human liver.
Topics: Adolescent; Adult; Blood Glucose; Cholesterol; Clofibrate; Clofibric Acid; Endoplasmic Reticulum; Fatty Acids, Nonesterified; Female; Humans; Liver; Male; Middle Aged; Time Factors; Triglycerides | 1980 |
20,25-Diazacholesterol, clofibric acid and 2,4-dichlorophenoxyacetic acid--all inducers of myotonia--perturb the post-lanosterol sector of sterol biosynthesis in cultured chick embryo fibroblasts.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acetates; Animals; Azacosterol; Cells, Cultured; Chick Embryo; Cholesterol; Chromatography, Gas; Clofibrate; Clofibric Acid; Fibroblasts; Lanosterol; Muscles; Sterols | 1980 |
Pharmacokinetics of bezafibrate after single and multiple doses in the presence of renal failure.
Topics: Adult; Bezafibrate; Clofibrate; Clofibric Acid; Drug Administration Schedule; Female; Humans; Kidney Diseases; Kinetics; Male; Middle Aged | 1980 |
Disposition of clofibrate in the rat. Acute and chronic administration.
Topics: Animals; Bile; Cholesterol; Cholestyramine Resin; Clofibrate; Clofibric Acid; Ethylmorphine; Feces; Male; Microsomes, Liver; Phenobarbital; Rats; Subcellular Fractions; Tissue Distribution; Triglycerides | 1980 |
[The therapeutic efficacy of bezafibrate in hyperlipoproteinemias of various types].
Topics: Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hyperlipoproteinemia Type V; Hyperlipoproteinemias; Lipoproteins, HDL; Triglycerides | 1980 |
Changes in lipids and lipoproteins in patients with hyperlipidemia type IIb, IV and V treated with different lipid lowering drugs.
Topics: Anticholesteremic Agents; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hyperlipoproteinemia Type V; Inositol; Lipoproteins; Nicotinic Acids; Xanthinol Niacinate | 1980 |
The effect of etofibrate retard, bezafibrate and procetofen.
Topics: Aged; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Female; Fenofibrate; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Lipoproteins; Male; Middle Aged; Patient Compliance; Propionates; Triglycerides | 1980 |
[Clofibrate therapy in hypercholesterolemia. Reports on medium-long-term movements of HDL- cholesterol by the action of clofibrate].
Topics: Adult; Bezafibrate; Clofibrate; Clofibric Acid; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Male; Middle Aged | 1980 |
[Comparative research on etofibrate retard and fenofibrate in hyperlipoproteinemia].
Topics: Aged; Cholesterol; Clofibrate; Clofibric Acid; Delayed-Action Preparations; Female; Fenofibrate; Humans; Hyperlipoproteinemias; Male; Middle Aged; Propionates; Triglycerides | 1980 |
Effects of clofibric acid on amino acid metabolism in cultured rat skeletal muscle.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Female; Glucose; Lactates; Male; Muscles; Pyruvates; Rats | 1981 |
Effect of hypolipidemic drugs gemfibrozil, ciprofibrate, and clofibric acid on peroxisomal beta-oxidation in primary cultures of rainbow trout hepatocytes.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enoyl-CoA Hydratase; Enzyme Activation; Fibric Acids; Gemfibrozil; Hypolipidemic Agents; Isomerases; Liver; Male; Microbodies; Multienzyme Complexes; Oncorhynchus mykiss; Oxidation-Reduction; Oxidoreductases; Peroxisomal Bifunctional Enzyme | 1993 |
[Pharmacokinetics of clofibrate in jaundiced newborn infants at term].
Topics: Anticholesteremic Agents; Clofibrate; Clofibric Acid; Drug Administration Schedule; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Male | 1995 |
Effect of peroxisomes proliferators and hypolipemic agents on mitochondrial inner membrane linked D-3-hydroxybutyrate dehydrogenase (BDH).
Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Binding, Competitive; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Hydroxybutyrate Dehydrogenase; Hypolipidemic Agents; In Vitro Techniques; Intracellular Membranes; Male; Microbodies; Mitochondria; Mitochondria, Liver; Phospholipids; Rats; Rats, Wistar; Tetrahymena pyriformis | 1995 |
Effects of clofibric and beclobric acid in rat and monkey hepatocyte primary culture: influence on peroxisomal and mitochondrial beta-oxidation and the activity of catalase, glutathione S-transferase and glutathione peroxidase.
Topics: Animals; Catalase; Cells, Cultured; Clofibrate; Clofibric Acid; Enzyme Activation; Glutathione Peroxidase; Glutathione Transferase; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Microbodies; Mitochondria, Liver; Oxidation-Reduction; Palmitates; Rats; Rats, Wistar | 1994 |
High-performance liquid chromatographic assay for the simultaneous determination of ethyl clofibrate and clofibric acid in plasma. Evaluation of plasma stability of ethyl clofibrate polylactic nanocapsules in human and rat plasmas.
Topics: Animals; Capsules; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Humans; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet | 1994 |
In vitro phototoxicity of clofibrate. Photochemical and photohemolytic studies on its metabolite clofibric acid.
Topics: Clofibrate; Clofibric Acid; Erythrocytes; Gas Chromatography-Mass Spectrometry; Hemolysis; Humans; Light; Molecular Structure; Photosensitizing Agents; Spectrophotometry, Ultraviolet | 1993 |
Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Dexamethasone; Enoyl-CoA Hydratase; Enzyme Induction; Genes, jun; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Mutagens; Precancerous Conditions; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Bezafibrate; Bile; Bile Canaliculi; Clofibrate; Clofibric Acid; DNA Primers; Drug Resistance, Multiple; Fenofibrate; Fibric Acids; Gemfibrozil; Gene Expression; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Multigene Family; Phospholipids; RNA, Messenger; RNA, Ribosomal, 18S | 1996 |
Growth regulation by peroxisome proliferators: opposing activities in early and late G1.
Topics: Animals; Bezafibrate; Carcinogens; Cell Cycle; Cell Line; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Mice; Microbodies; Pyrimidines; Signal Transduction; Time Factors; Transcriptional Activation | 1996 |
No effect of fibrates on synthesis of apolipoprotein(a) in primary cultures of cynomolgus monkey and human hepatocytes: apolipoprotein A-I synthesis increased.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Bezafibrate; Cells, Cultured; Clofibrate; Clofibric Acid; Gemfibrozil; Humans; Liver; Macaca fascicularis | 1998 |
Activation of human liver 3alpha-hydroxysteroid dehydrogenase by clofibrate derivatives.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Binding Sites; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Enzyme Activation; Fenofibrate; Humans; Hydrogen-Ion Concentration; Hydroxysteroid Dehydrogenases; Hypolipidemic Agents; Liver | 1998 |
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
Induction of lauric acid hydroxylase activity in catfish and bluegill by peroxisome proliferating agents.
Topics: Animals; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fibric Acids; Ictaluridae; Kidney; Liver; Male; Mixed Function Oxygenases; Perciformes; Peroxisome Proliferators; Rats; Species Specificity | 1998 |
Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.
Topics: Animals; Cells, Cultured; Clofibrate; Clofibric Acid; DNA-Binding Proteins; Fenofibrate; Fibric Acids; Fibrinogen; Gene Expression Regulation; Hypolipidemic Agents; Kinetics; Liver; Male; Mice; Mice, Knockout; Peroxisome Proliferators; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Transcription, Genetic; Triglycerides | 1999 |
The effect of peroxisome proliferators on mitochondrial bioenergetics.
Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene | 1999 |
Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1A1, 1A2, 3A and 4A1.
Topics: Analysis of Variance; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Female; Fibric Acids; Genetic Techniques; Glucocorticoids; Humans; Liver; Mixed Function Oxygenases; Nucleic Acid Hybridization; Oligonucleotides, Antisense; Oxidoreductases, N-Demethylating; Peroxisome Proliferators; Protein Isoforms; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2000 |
Different behavior toward racemization in basic media from chiral analogs of clofibric acid, the active metabolite of the antilipidemic drug clofibrate.
Topics: Clofibrate; Clofibric Acid; Esters; Hydrolysis; Hypolipidemic Agents; Indicators and Reagents; Molecular Conformation; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2000 |
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
Topics: Aldehydes; Cell Differentiation; Cell Division; Chromans; Clofibrate; Clofibric Acid; Drug Synergism; Fibric Acids; HL-60 Cells; Humans; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; U937 Cells | 2002 |
Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells.
Topics: Bezafibrate; Clofibrate; Clofibric Acid; Disease Models, Animal; Drug Synergism; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma, Embryonal; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Tumor Cells, Cultured | 2003 |
Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Chromans; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression; HL-60 Cells; Humans; Ligands; Oncogenes; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.
Topics: Acyl-CoA Oxidase; Animals; Carnitine Acyltransferases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clofibrate; Clofibric Acid; Fibric Acids; Gene Expression Regulation; Hepatocytes; Humans; Male; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Promoter Regions, Genetic; Pyrimidines; Rats; Rats, Wistar; Response Elements; Species Specificity; Transfection | 2004 |
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents | 2004 |
Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Catalase; Clofibrate; Clofibric Acid; Cyprinodontiformes; Female; L-Lactate Dehydrogenase; Liver; Male; Muscle, Skeletal; Organ Size; Sex Factors; Water Pollutants, Chemical | 2004 |
Acute toxicity of widely used pharmaceuticals in aquatic species: Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii.
Topics: Animals; Anticonvulsants; Artemia; Clofibrate; Clofibric Acid; Cyprinodontiformes; Detergents; Diazepam; Eukaryota; Hypolipidemic Agents; Lethal Dose 50; Reference Values; Sodium Dodecyl Sulfate; Water Pollutants, Chemical | 2005 |
Effects of widely used pharmaceuticals and a detergent on oxidative stress biomarkers of the crustacean Artemia parthenogenetica.
Topics: Animals; Artemia; Biomarkers; Cholinesterases; Clofibrate; Clofibric Acid; Detergents; Diazepam; Female; Glutathione Peroxidase; Glutathione Reductase; Oxidative Stress; Sodium Dodecyl Sulfate | 2006 |
Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study.
Topics: Androgens; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Biomarkers; Carps; Clofibrate; Clofibric Acid; Diclofenac; Fibric Acids; Fluoxetine; Gemfibrozil; Ibuprofen; Male; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Testis; Water Pollutants, Chemical | 2011 |