clofibrate and rifampin

clofibrate has been researched along with rifampin in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.00)18.7374
1990's3 (15.00)18.2507
2000's3 (15.00)29.6817
2010's11 (55.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kump, W; Mueller, K; Tosch, W; Traxler, P1
Strassburg, CP; Tukey, RH1
Andricopulo, AD; Moda, TL; Montanari, CA1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Houin, G; Tillement, JP1
Crepaldi, G; Jemmolo, RM; Lirussi, F; Muraca, M; Nassuato, G; Okolicsanyi, L; Orlando, R; Strazzabosco, M1
O'Reilly, RA1
Hirata, M; Nishibe, Y1
Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM1
Jemnitz, K; Lengyel, G; Vereczkey, L1

Reviews

4 review(s) available for clofibrate and rifampin

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The effect of drugs on bile flow and composition. An overview.
    Drugs, 1986, Volume: 31, Issue:5

    Topics: Animals; Bile; Bile Acids and Salts; Cats; Chlorpromazine; Cholagogues and Choleretics; Cholesterol; Clofibrate; Colchicine; Cricetinae; Dehydrocholic Acid; Diuretics; Dogs; Enterohepatic Circulation; Estrogens; Glucagon; Guinea Pigs; Humans; Insulin; Liver; Macaca mulatta; Phospholipids; Rabbits; Rats; Rifampin; Rifamycins; Somatostatin; Theophylline; Ursodeoxycholic Acid

1986
Warfarin metabolism and drug-drug interactions.
    Advances in experimental medicine and biology, 1987, Volume: 214

    Topics: Anti-Bacterial Agents; Aspirin; Barbiturates; Cholestyramine Resin; Clofibrate; Diuretics; Drug Interactions; Ethanol; Humans; Rifampin; Vitamin K; Warfarin

1987

Other Studies

16 other study(ies) available for clofibrate and rifampin

ArticleYear
Hypolipidemic activity of rifamycin derivatives.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: Animals; Chemical Phenomena; Chemistry; DNA-Directed RNA Polymerases; Hypolipidemic Agents; Rats; Rats, Inbred Strains; Rifamycins; Staphylococcal Infections; Structure-Activity Relationship

1990
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Clofibrate and enzymatic induction in man.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:4

    Topics: Adult; Antipyrine; Clofibrate; Enzyme Induction; Half-Life; Humans; Kinetics; Male; Rifampin

1978
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:8

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases

1995
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3

    Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics

1999
In vitro induction of bilirubin conjugation in primary rat hepatocyte culture.
    Biochemical and biophysical research communications, 2002, Feb-15, Volume: 291, Issue:1

    Topics: Animals; Bilirubin; Cells, Cultured; Clofibrate; Dexamethasone; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glucocorticoids; Glucuronosyltransferase; Hepatocytes; Hypolipidemic Agents; Immunoblotting; Isoenzymes; Male; Methylcholanthrene; Rats; Rats, Wistar; Rifampin

2002