Compounds > clofibrate

clofibrate and pregnenolone carbonitrile

clofibrate has been researched along with pregnenolone carbonitrile in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's2 (28.57)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET1
Amacher, DE; Schomaker, SJ1
Carmichael, N; Debruyne, E; Lassere, D; Nicod, L; Richert, L; Viollon-Abadie, C1
Law, MY; Moody, DE; Slawson, MH1
Chichester, CO; Deng, R; Li, Y; Liu, J; Ma, Y; Sachdeva, K; Song, X; Yan, B; Yang, D1

Other Studies

7 other study(ies) available for clofibrate and pregnenolone carbonitrile

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
    Molecular pharmacology, 1985, Volume: 28, Issue:3

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin

1985
Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes.
    Toxicology letters, 1998, Jan-31, Volume: 94, Issue:2

    Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biomarkers; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Ethylmorphine-N-Demethylase; Female; Isoniazid; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sex Factors

1998
Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice.
    Toxicology and applied pharmacology, 1999, Feb-15, Volume: 155, Issue:1

    Topics: Animals; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Liver; Male; Mice; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones

1999
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:3

    Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole

2000
Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23.
    Biochemical pharmacology, 2005, May-01, Volume: 69, Issue:9

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Clofibrate; Cytochrome P-450 CYP3A; Dactinomycin; Decanoic Acids; Fluorocarbons; Hepatocytes; Ligands; Male; Pregnane X Receptor; Pregnenolone Carbonitrile; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Up-Regulation

2005