clofibrate has been researched along with phenobarbital in 106 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (36.79) | 18.7374 |
| 1990's | 36 (33.96) | 18.2507 |
| 2000's | 16 (15.09) | 29.6817 |
| 2010's | 14 (13.21) | 24.3611 |
| 2020's | 1 (0.94) | 2.80 |
| Authors | Studies |
|---|---|
| Branzoli, U; Carganico, G; Chiari, A; Cozzi, P; Lovisolo, PP; Orsini, G; Pillan, A | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Just, C; Kutz, K; Lindstaedt, H; Reiter, B; Schulte, A | 1 |
| Gógl, A; Klinger, W; Müller, D; Ruzsa, C; Simon, K; Vezekényi, Z | 1 |
| Levy, VG; Noel, P; Nusinovici, V | 1 |
| Mori, T; Ohyama, K; Takashima, K; Takeyama, S | 1 |
| Paumgartner, G | 1 |
| Bieber, LL; Markwell, MA; Tolbert, NE | 1 |
| Brunner, G | 1 |
| Phillips, WA; Ratchford, JM; Schultz, JR | 1 |
| Morrissey, KP | 1 |
| Aoki, T; Hakoi, K; Ito, N; Kato, T; Ozaki, K; Sato, K; Tsuda, H; Uwagawa, S; Yamaguchi, S | 1 |
| Close, I; Gibson, GG; Goldfarb, PS; Howes, D; Shackleton, G; Sharma, R | 1 |
| Bursch, W; Gerbracht, U; Kraus, P; Putz, B; Reinacher, M; Schulte-Hermann, R; Timmermann-Trosiener, I | 1 |
| Blaauboer, BJ; de Kruif, CA; Falke, HE; Noordhoek, J; van Iersel, AA; Wortelboer, HM | 1 |
| Miyazaki, S | 1 |
| Burnett, AK; Craft, JA; Lambard, SE; Wolf, CR | 1 |
| Holsztynska, EJ; Iscan, M; Lester, R; Radominska, A; Waxman, DJ; Zimniak, P | 1 |
| Gabilan, JC | 1 |
| Bui, QD; Weisz, J; Wrighton, SA | 1 |
| Aoki, T; Ito, N; Mutai, M; Tatematsu, M; Wada, S | 1 |
| Appelkvist, EL; Dallner, G; Kalén, A | 1 |
| Gibson, GG; MacNicoll, AD; Sutcliffe, FA | 1 |
| Cruise, JL; Michalopoulos, GK; Tsai, WH | 1 |
| Kitagawa, T; Lee, GH; Nomura, K | 1 |
| Appelkvist, EL; Kalén, A | 1 |
| Brealey, CJ; Clarke, SE; Gibson, GG | 1 |
| Bridges, JW; Greaves, P; Irisarri, E; Mompon, P; Monro, AM | 1 |
| Greaves, P; Irisarri, E; Monro, AM | 1 |
| Bawden, MJ; Hansen, AJ; May, BK; Srivastava, G | 1 |
| Clark, TD; Glauert, HP | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
| Appelkvist, EL; Bäckman, L; Dallner, G; Ringdén, O | 1 |
| Buffoni, F; Cintelli, A; Ignesti, G; Perretti, M | 1 |
| Appelkvist, EL; Bäckman, L; Dallner, G | 1 |
| Boobis, AR; Davies, DS; Elcombe, CR; Foster, JR; Hayward, C; Lock, EA; McQuade, J; Robson, RT; Sesardic, D | 1 |
| Heinemeyer, G; Hildebrandt, AG; Nau, H; Roots, I | 1 |
| Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET | 1 |
| Dalton, C; Hope, HR; Hope, WC; Sheppard, H | 1 |
| McIntosh, DA; Topham, JC | 1 |
| Bell, GD | 1 |
| Feller, DR; Lewis, NJ; Poochikian, GK; Witiak, DT | 1 |
| Borsy, J; Elek, S; Jámbor, E; Maderspach, A; Osváth, Z; Polgári, I | 1 |
| Russell, DH | 1 |
| Abrams, WB; Reich, S; Solomon, HM; Spirt, N | 1 |
| Hirayama, C; Kishimoto, Y | 1 |
| Ikeda, T; Kessler, DJ; Nebert, DW; Stupans, I | 1 |
| Axelson, JE; du Souich, P; Elvin, AT; Golden, LH; Lalka, D; McLean, AJ; Stoeckel, K | 1 |
| Berman, JS; Hiley, CR; Wilson, AC | 1 |
| Lalwani, ND; Reddy, JK; Reddy, MK; Warren, JR | 1 |
| Gibson, GG; Orton, TC; Tamburini, PP | 1 |
| Baldwin, JR; Feller, DR; Witiak, DT | 1 |
| Alterman, MA; Chaurasia, CS; Hanzlik, RP; Lu, P | 1 |
| Duclos, S; Goudonnet, H; Hamdoune, M; Lhuguenot, JC; Magdalou, J; Mounie, J; Santona, L | 1 |
| Groth-Watson, A; Kelley, M; Knoble, D; Kornbrust, D | 1 |
| Cui, L; Futakuchi, M; Hasegawa, R; Ito, N; Kim, DJ; Mizoguchi, Y; Yoshida, T | 1 |
| Hayes, JD; Judah, DJ; McLellan, LI; Neal, GE | 1 |
| Blaauboer, BJ; Luijckx, NB; Mennes, WC; Noordhoek, J; Wortelboer, HM | 1 |
| Waxman, DJ; Weber, GF | 1 |
| Hirata, M; Nishibe, Y | 1 |
| Borhan, B; Hammock, BD; Moghaddam, M; Motoba, K; Pinot, F | 1 |
| Boucher, JL; Delaforge, M; Durst, F; Mioskowski, C; Pflieger, P; Pinot, F; Salaün, JP | 1 |
| Bjorge, SM; Black, AE; Holmes, A; Sinz, MW; Trivedi, BK; Woolf, TF | 1 |
| Barnett, CR; Clarke, J; Coulter, J; Flatt, PR | 1 |
| Delaforge, M; Le Campion, L; Noel, JP; Ouazzani, J | 1 |
| Mock, DM; Mock, NI; Wang, KS | 1 |
| Kauffmann, HM; Schrenk, D | 1 |
| Amacher, DE; Schomaker, SJ | 1 |
| Alvarez, AM; Cascales, M; Díez-Fernández, C; Sanz, N; Wolf, A | 1 |
| Baker, GB; Coutts, RT; Fang, J; McKenna, KF | 1 |
| Hong, JT; Kim, DJ; Lee, KK | 1 |
| Alworth, WL; Ertl, RP; Winston, GW | 1 |
| Carmichael, N; Debruyne, E; Lassere, D; Nicod, L; Richert, L; Viollon-Abadie, C | 1 |
| Buchmann, A; Buenemann, CL; Schmiechen, A; Schwarz, M; Stroh, C; Willy, C | 1 |
| Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM | 1 |
| Aversa, E; Bonazzi, A; Mastyugin, V; Mieyal, P; Schwartzman, ML; Vafaes, C | 1 |
| Law, MY; Moody, DE; Slawson, MH | 1 |
| Kagayama, A; Mitani, Y; Niwa, T; Shiraga, T; Terakawa, M; Tokuma, Y | 1 |
| Amato, G; Gervasi, PG; Giorgi, M; Longo, V; Marini, S; Mazzaccaro, A | 1 |
| Edwards, RJ; Guengerich, FP; Hollenberg, PF; Kim, H; Novak, RF; Putt, DA; Wolf, CR; Zangar, RC | 1 |
| Austin, C; Caskey, CT; Gerhold, D; Lu, M; Rushmore, T; Xu, J | 1 |
| Afshari, CA; Barrett, JC; Bennett, L; Blanchard, K; Bushel, PR; DiSorbo, O; Hamadeh, HK; Jayadev, S; Martin, K; Paules, RS; Sieber, S; Stoll, R; Tennant, R | 1 |
| Dennery, PA | 1 |
| Ito, K; Kanbori, M; Kiyosawa, N; Manabe, S; Niino, N; Sakuma, K; Watanabe, T; Yamoto, T | 1 |
| Ito, K; Kanbori, M; Kiyosawa, N; Manabe, S; Matsunuma, N; Niino, N; Sakuma, K; Yamoto, T | 1 |
| Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M | 1 |
| Fukuyama, T; Ikari, A; Ikushiro, S; Miwa, M; Osabe, M; Sugatani, J | 1 |
| Chu, I; Gu, YZ; Kumari, P; Lin, X; Mandakas, G; Palamanda, J; Smith, RJ; Snyder, RD; Soares, A; Wang, EJ | 1 |
| Ando, Y; Kiyosawa, N; Manabe, S; Niino, N; Watanabe, K; Yamoto, T | 1 |
| Aleksunes, LM; Corton, JC; George, MH; Klaassen, CD; Ren, H; Vallanat, B; Wood, C | 1 |
| Ando, Y; Arakawa, S; Ito, K; Kinoshita, J; Makino, T; Nakayama, H; Sanbuissho, A; Teranishi, M; Yamoto, T | 1 |
| Degawa, M; Gamou, T; Habano, W; Hikida, T; Ikeda, A; Inoue, K; Ito, S; Mizukami, M; Nemoto, K; Nishikawa, A; Ozawa, S; Tanaka, T; Yoshida, M | 1 |
| Degawa, M; Gamou, T; Habano, W; Inoue, K; Nemoto, K; Nishikawa, A; Ozawa, S; Yoshida, M | 1 |
| Degawa, M; Fujimoto, N; Gamou, T; Inoue, K; Nemoto, K; Nishikawa, A; Ozawa, S; Yoshida, M | 1 |
| Fukushima, K; Fukushima, N; Hirane, M; Honoki, K; Ishii, S; Takahashi, K; Tomimatsu, A; Tsujiuchi, T | 1 |
| Asaoka, Y; Imura, N; Miyamoto, Y; Miyoshi, T; Mutsuga, M; Togashi, Y | 1 |
| Beger, RD; Chalbot, MG; Johnson, K; Kavouras, IG; Koturbash, I; LeBaron, MJ; Lin, H; Miousse, IR; Murphy, LA; Rasoulpour, RJ; Schisler, MR; Schnackenberg, LK; Sun, J; Sura, R | 1 |
| Ji, Z; LeBaron, MJ; Settivari, RS | 1 |
| Buck, WR; Fossey, S; Liguori, MJ; Sharapova, T; Talaty, N; Van Vleet, TR | 1 |
9 review(s) available for clofibrate and phenobarbital
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[What is reliable in the internal therapy of the gallstone trouble?].
Topics: Bile; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Clofibrate; Diet; Dose-Response Relationship, Drug; Estrogens; Humans; Lipid Metabolism; Liver; Phenobarbital; Thyroxine | 1975 |
Current concepts of gallstone formation.
Topics: Animals; Bile; Bile Acids and Salts; Cholecystectomy; Cholelithiasis; Cholesterol; Cholestyramine Resin; Clofibrate; Diet; Gallbladder; Hormones; Humans; Metabolic Diseases; Nicotinic Acids; Phenobarbital; Phosphatidylcholines; Phospholipids; Thyroxine | 1975 |
[Pharmacologic treatment of neonatal jaundice].
Topics: Clofibrate; Humans; Infant, Newborn; Jaundice, Neonatal; Metalloporphyrins; Phenazines; Phenobarbital | 1991 |
[Effects of alcohol and medication on bile acid metabolism].
Topics: Animals; Bile Acids and Salts; Cholelithiasis; Cholesterol, HDL; Clofibrate; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Ethanol; Humans; Phenobarbital; Rats | 1984 |
Hepatic and renal effects of peroxisome proliferators: biological implications.
Topics: Allylisopropylacetamide; Animals; Carnitine O-Acetyltransferase; Catalase; Clofibrate; Kidney; Lipid Metabolism; Lipofuscin; Liver; Mice; Microbodies; Mitotane; Organoids; Peptides; Phenobarbital; Rats | 1982 |
Pharmacological interventions for the treatment of neonatal jaundice.
Topics: Agar; Bilirubin; Charcoal; Clofibrate; Drugs, Chinese Herbal; Heme; Humans; Infant, Newborn; Jaundice, Neonatal; Liver Circulation; Metalloporphyrins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Penicillamine; Phenobarbital; Treatment Outcome | 2002 |
Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Topics: Animals; Clofibrate; Constitutive Androstane Receptor; Diethylhexyl Phthalate; Gene Expression Profiling; Gene Expression Regulation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; Phenobarbital; Plasticizers; PPAR alpha; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Valproic Acid | 2010 |
97 other study(ies) available for clofibrate and phenobarbital
| Article | Year |
|---|---|
N-imidazolylchroman-4-ones, N-imidazolyl-1-tetralones, and their alcohols as hypolipemic agents raising high-density lipoproteins.
Topics: Alcohols; Animals; Cholesterol; Enzyme Induction; Hypercholesterolemia; Hypolipidemic Agents; Imidazoles; In Vitro Techniques; Lipoproteins, HDL; Liver; Male; Microbodies; Microsomes, Liver; Organ Size; Pyrimidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Bile formation and biliary lipid composition under the influence of clofibrate and phenobarbital pretreatment in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Body Weight; Cholesterol; Clofibrate; Lipid Metabolism; Liver; Male; Organ Size; Phenobarbital; Phospholipids; Rats; Taurocholic Acid | 1979 |
Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat.
Topics: Adolescent; Adult; Animals; Chemical Phenomena; Chemistry; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gilbert Disease; Humans; Liver; Male; Microsomes, Liver; Middle Aged; Organ Size; Phenobarbital; Rats; Sleep | 1979 |
[Enzyme induction and intrahepatic cholestasis].
Topics: Bilirubin; Cholestasis; Clofibrate; Coenzyme A Ligases; Enzyme Induction; Glucuronates; Glutethimide; Hexosyltransferases; Humans; Phenobarbital | 1978 |
Hypolipidemic effect of alpha-mono-p-myristyloxy-alpha'-methylcinnamoyl glycerol (LK-903) in rats.
Topics: Animals; Cinnamates; Clofibrate; Diet; Fatty Liver; Glycerides; Hypolipidemic Agents; Intubation, Gastrointestinal; Lipid Metabolism; Lipids; Liver; Male; Phenobarbital; Rats | 1978 |
Differential increase of hepatic peroxisomal, mitochondrial and microsomal carnitine acyltransferases in clofibrate-fed rats.
Topics: Acyltransferases; Animals; Body Weight; Carnitine Acyltransferases; Centrifugation, Density Gradient; Clofibrate; Liver; Male; Microbodies; Microsomes, Liver; Mitochondria, Liver; Organ Size; Organoids; Phenobarbital; Rats; Stimulation, Chemical | 1977 |
[Therapy of the chronic destructive, non-purulent cholangitis (primary biliary cirrhosis)].
Topics: Azathioprine; Calcium; Cholangitis; Cholestyramine Resin; Clofibrate; Humans; Hypercholesterolemia; Liver Cirrhosis, Biliary; Osteoporosis; Phenobarbital; Pruritus; Vitamin D | 1976 |
Effects of colestipol hydrochloride on drug absorption in the rat II.
Topics: Animals; Cellulose; Chlorpromazine; Cholestyramine Resin; Clofibrate; Colestipol; Digitoxin; Digoxin; Hydrochlorothiazide; Intestinal Absorption; Male; Nicotinic Acids; Pharmaceutical Preparations; Phenobarbital; Polyamines; Rats; Tetracycline; Warfarin | 1976 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Ethoxyquin; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glutathione Transferase; Isoenzymes; Liver Neoplasms, Experimental; Male; Phenobarbital; Phenotype; Precancerous Conditions; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 1992 |
Influence of single and concurrent clofibrate and phenobarbital administration on cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation in male rat liver.
Topics: Animals; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme System; Drug Interactions; Liver; Male; Microbodies; Mixed Function Oxygenases; Organ Size; Phenobarbital; Rats; Rats, Wistar | 1992 |
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Female; Glutathione Transferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Nafenopin; Nitrosamines; Organ Size; Phenobarbital; Phenotype; Precancerous Conditions; Propionates; Rats; Rats, Inbred Strains | 1990 |
Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities.
Topics: Animals; Apoproteins; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Blotting, Western; Cells, Cultured; Clofibrate; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Enzyme Induction; Isoenzymes; Isoniazid; Liver; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1991 |
Effect of chemicals on glutathione peroxidase of chick liver.
Topics: Animals; Benzene Derivatives; Butylated Hydroxyanisole; Chickens; Chromatography, Gel; Clofibrate; Glutathione Peroxidase; Hydrogen Peroxide; Liver; Male; Methylcholanthrene; Phenobarbital; Stilbenes | 1991 |
The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azo Compounds; Benzoflavones; Blotting, Western; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Isoenzymes; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Troleandomycin | 1991 |
Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids.
Topics: Androstenedione; Animals; Bile Acids and Salts; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Hydroxylation; Lithocholic Acid; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Steroid Hydroxylases; Steroids | 1991 |
Hepatic catecholestrogen synthases: differential effect of sex, inducers of cytochromes P-450 and of antibody to the glucocorticoid inducible cytochrome P-450 on NADPH-dependent estrogen-2-hydroxylase and on organic hydroperoxide-dependent estrogen-2/4-hy
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Estradiol; Estrogens, Catechol; Female; Isoniazid; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1990 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1990 |
The effects of inducers of the endoplasmic reticulum, peroxisomes and mitochondria on the amounts and synthesis of ubiquinone in rat liver subcellular membranes.
Topics: Animals; Cholesterol, Dietary; Cholestyramine Resin; Chromatography, High Pressure Liquid; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Dolichols; Endoplasmic Reticulum; Intracellular Membranes; Liver; Methylcholanthrene; Mevalonic Acid; Microbodies; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Ubiquinone | 1990 |
Hepatic microsomal warfarin metabolism in warfarin-resistant and susceptible mouse strains: influence of pretreatment with cytochrome P-450 inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Female; Male; Mice; Microsomes, Liver; Phenobarbital; Sex Factors; Species Specificity; Stereoisomerism; Warfarin | 1990 |
Blockade of alpha-1 adrenergic receptor inhibits hepatic DNA synthesis stimulated by tumor promoters.
Topics: Animals; Carcinogens; Clofibrate; Clofibric Acid; DNA; Fibric Acids; Hexachlorocyclohexane; Liver; Organ Size; Phenobarbital; Prazosin; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha | 1989 |
Comparative study of diethylnitrosamine-initiated two-stage hepatocarcinogenesis in C3H, C57BL and BALB mice promoted by various hepatopromoters.
Topics: Animals; Clofibrate; Diethylnitrosamine; Ethinyl Estradiol; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital; Species Specificity | 1989 |
Biosynthesis of dolichol by rat liver peroxisomes.
Topics: Animals; Cholestyramine Resin; Chromatography, High Pressure Liquid; Clofibrate; Detergents; Dolichols; Endoplasmic Reticulum; Hydrogen-Ion Concentration; Intracellular Membranes; Liver; Male; Mevalonic Acid; Microbodies; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Inbred Strains | 1989 |
Cytochrome P-450 in the housefly: induction, substrate specificity and comparison to three rat hepatic isoenzymes.
Topics: Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Houseflies; Isoenzymes; Male; Microsomes; Microsomes, Liver; Phenobarbital; Rats | 1989 |
A cytochemical study of the livers of rats treated with diethylnitrosamine/phenobarbital, with benzidine/phenobarbital, with phenobarbital, or with clofibrate.
Topics: Administration, Oral; Animals; Benzidines; Clofibrate; Diethylnitrosamine; Drug Interactions; Glucose-6-Phosphatase; Injections, Intraperitoneal; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Histocytochemistry; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Heme may not be a positive regulator of cytochrome-P450 gene expression.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Gene Expression Regulation; Genes; Heme; Humans; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Transcription, Genetic | 1989 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Female; Fibric Acids; Liver; Liver Neoplasms, Experimental; Microbodies; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Effects of cyclosporine A on hepatic protein synthesis.
Topics: Animals; Cell-Free System; Clofibrate; Cyclosporins; Liver; Membrane Proteins; Microsomes, Liver; Molecular Weight; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; Phenobarbital; Phthalic Acids; Protein Biosynthesis; Puromycin; Quinone Reductases; Rats | 1988 |
Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers.
Topics: Amine Oxidase (Copper-Containing); Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofibrate; Enzyme Induction; Histamine; In Vitro Techniques; Microsomes, Liver; Phenobarbital; Putrescine; Quail; Substrate Specificity | 1988 |
Influence of cyclosporine A on protein synthesis in rat liver.
Topics: Animals; Autoradiography; Clofibrate; Cyclosporins; Electrophoresis, Polyacrylamide Gel; Esters; Immunosuppression Therapy; Liver; Male; Microbodies; Microsomes, Liver; Phenobarbital; Phthalic Acids; Protein Biosynthesis; Puromycin; Rats; Rats, Inbred Strains | 1988 |
Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c.
Topics: Adrenal Glands; Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Histocytochemistry; Immunoenzyme Techniques; Intestine, Small; Isoenzymes; Kidney; Liver; Lung; Male; Mice; Olfactory Mucosa; Phenobarbital; Rats; Rats, Inbred Strains; Testis | 1986 |
Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Enzyme Induction; Flavonoids; Glucuronates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin | 1985 |
Relationship of serum triglyceride lowering to changes in hepatic composition induced by different classes of drugs.
Topics: Animals; Cholesterol; Clofibrate; Dactinomycin; DNA; Dose-Response Relationship, Drug; Glycolates; Hepatomegaly; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Nafenopin; Oxidoreductases, N-Demethylating; Phenobarbital; Phenyl Ethers; Phenytoin; Phospholipids; Piperazines; Piperidines; Propionates; Proteins; Rats; RNA; Spectrophotometry, Ultraviolet; Triglycerides | 1974 |
A comparison of mouse and rat liver enzymes and their response to treatment with various compounds.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Chlorpromazine; Clofibrate; Cytochromes; DDT; Germ-Free Life; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Griseofulvin; L-Lactate Dehydrogenase; Liver; Mice; NAD; NADP; Organ Size; Oxidoreductases; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Species Specificity | 1972 |
The present position concerning gallstone dissolution.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Humans; Phenobarbital; Phospholipids; Solvents | 1974 |
Differential effects of benzodioxane, chroman, and dihydrobenzofuran analogs of clofibrate on various parameters of hepatic drug metabolism.
Topics: Aniline Compounds; Animals; Benzofurans; Benzopyrans; Body Weight; Clofibrate; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Organ Size; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phenobarbital; Proteins; Rats; Structure-Activity Relationship | 1974 |
[The effect of clofibrate (ethyl-p-chlorophenoxy isobutyrate), M-451 (bis-p-chlorophenoxy-acetylurea) and phenobarbital on experimental liver damage in rats].
Topics: Animals; Carbon Tetrachloride Poisoning; Clofibrate; Cyanates; Ethionine; Hepatitis, Animal; Liver; Phenobarbital; Rats | 1974 |
Drug stimulation of putrescine and spermidine syntheses. Relationships to enhancement of ribonucleic acid synthesis.
Topics: Animals; Benzopyrenes; Carboxy-Lyases; Clofibrate; Cycloheximide; Heparin; Liver; Male; Methylcholanthrene; Ornithine; Phenobarbital; Polyamines; Putrescine; Rats; RNA; S-Adenosylmethionine; Spermidine; Stimulation, Chemical; Tritium; Uridine | 1971 |
Interactions between digitoxin and other drugs in vitro and in vivo.
Topics: Binding Sites; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Clofibrate; Digitoxin; Digoxin; Drug Antagonism; Enzyme Induction; Erythrocytes; Humans; Microsomes, Liver; Phenobarbital; Phenylbutazone; Phenytoin; Protein Binding; Radioisotopes; Rubidium; Serum Albumin; Sulfadimethoxine; Tolbutamide; Tritium; Warfarin | 1971 |
Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b.
Topics: Amino Acid Sequence; Animals; Base Sequence; Clofibrate; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Methylcholanthrene; Mice; Phenobarbital; Rabbits; Rats; Species Specificity | 1984 |
Tocainide kinetics and metabolism: effects of phenobarbital and substrates of glucuronyl transferase.
Topics: Adult; Anilides; Anti-Arrhythmia Agents; Clofibrate; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Humans; Kinetics; Male; Phenobarbital; Salicylamides; Tocainide | 1980 |
Comparison of the effects of the hypolipidaemic agents ICI53072 and clofibrate with those of phenobarbitone on liver size, blood flow and DNA content in the rat.
Topics: Animals; Bile; Cardiac Output; Clofibrate; DNA; Hepatomegaly; Hypolipidemic Agents; Liver; Liver Circulation; Male; Microsomes, Liver; Phenobarbital; Propionates; Proteins; Rats; Rats, Inbred Strains | 1983 |
Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid).
Topics: Animals; Benzphetamine; Catalysis; Clofibrate; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Induction; Kinetics; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Disposition of clofibrate in the rat. Acute and chronic administration.
Topics: Animals; Bile; Cholesterol; Cholestyramine Resin; Clofibrate; Clofibric Acid; Ethylmorphine; Feces; Male; Microsomes, Liver; Phenobarbital; Rats; Subcellular Fractions; Tissue Distribution; Triglycerides | 1980 |
Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation.
Topics: Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Hydroxylation; Isoenzymes; Lauric Acids; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Structure-Activity Relationship | 1995 |
In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs.
Topics: Animals; Body Weight; Caproates; Chromatography, High Pressure Liquid; Clofibrate; Glucuronates; Glucuronosyltransferase; Male; Microbodies; Microsomes, Liver; Phenobarbital; Rats; Rats, Gunn; Rats, Wistar; Species Specificity; Stereoisomerism; Structure-Activity Relationship | 1995 |
Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist.
Topics: Animals; Cells, Cultured; Clofibrate; Dogs; Enzyme Induction; Guinea Pigs; Leukotriene D4; Liver; Male; Mice; Microbodies; Oxidoreductases; Phenobarbital; Quinolines; Rats; Rats, Sprague-Dawley; Tetrazoles | 1994 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1994 |
Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.
Topics: Aflatoxin B1; Aldehyde Reductase; Animals; Anticarcinogenic Agents; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Clofibrate; Enzyme Induction; Ethoxyquin; Glutathione Transferase; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred F344; Tissue Distribution; Xenobiotics | 1994 |
Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver.
Topics: Animals; Antihypertensive Agents; Benzoflavones; beta-Naphthoflavone; Biotransformation; Clofibrate; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Species Specificity | 1993 |
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Topics: Animals; Antibodies; Biotransformation; Cisplatin; Clofibrate; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Ifosfamide; Kinetics; Male; Microsomes, Liver; Models, Chemical; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1993 |
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases | 1995 |
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Linoleic Acid; Linoleic Acids; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Trichloroepoxypropane | 1996 |
In vitro hydroxylation and epoxidation of some isomeric lauric acid analogs by rat liver microsomes. Identification of metabolites and effects of clofibrate or phenobarbital pretreatment.
Topics: Animals; Chromatography, Thin Layer; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Lauric Acids; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley | 1996 |
In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats.
Topics: Anilides; Animals; Cells, Cultured; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Feces; Female; Liver; Male; Phenobarbital; Rats; Rats, Wistar; Sterol O-Acyltransferase | 1997 |
Islet antioxidant and second phase enzyme levels following CYP1A, CYP2E, CYP2B and CYP4A induction.
Topics: Acetone; Animals; Antioxidants; Catalase; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Islets of Langerhans; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Superoxide Dismutase | 1997 |
Metabolism of 14C-labelled 5-nitro-1,2,4-triazol-3-one by rat liver microsomes--evidence for the participation of cytochrome P-450.
Topics: Animals; Carbon Radioisotopes; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Fungal Proteins; Glucocorticoids; Male; Methylcholanthrene; Microsomes, Liver; Nitro Compounds; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1997 |
Biotin biotransformation to bisnorbiotin is accelerated by several peroxisome proliferators and steroid hormones in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Biotin; Biotransformation; Carbamazepine; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Clofibrate; Dehydroepiandrosterone; Dexamethasone; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Male; Microbodies; Phenobarbital; Phenytoin; Radiometry; Rats; Rats, Sprague-Dawley; Steroids | 1997 |
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene.
Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Carcinoma, Hepatocellular; Cisplatin; Clofibrate; Cloning, Molecular; Ethinyl Estradiol; Gene Expression Regulation, Neoplastic; Genes, MDR; Genes, Reporter; Phenobarbital; Rats; RNA, Messenger; Sequence Analysis, DNA; Transfection; Tumor Cells, Cultured | 1998 |
Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biomarkers; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Ethylmorphine-N-Demethylase; Female; Isoniazid; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sex Factors | 1998 |
The effect of non-genotoxic carcinogens, phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Catalase; Cells, Cultured; Clofibrate; Gene Expression Regulation, Enzymologic; Liver; Male; Peroxides; Phenobarbital; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Transforming Growth Factor beta | 1998 |
Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine.
Topics: Animals; Chromatography, High Pressure Liquid; Clofibrate; Clozapine; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Phenobarbital; Rats; Substrate Specificity | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; Glutathione Transferase; Injections, Intraperitoneal; Liver Neoplasms; Male; Mutagens; Organ Size; Phenobarbital; Precancerous Conditions; Quinolines; Rats; Rats, Inbred F344 | 1998 |
Liver microsomal cytochromes P450-dependent alkoxyphenoxazone O-dealkylation in vitro by alligator and rat: activities, inhibition, substrate preference, and discrimination factors.
Topics: Alligators and Crocodiles; Animals; Chlorodiphenyl (54% Chlorine); Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Species Specificity; Substrate Specificity | 1999 |
Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice.
Topics: Animals; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Liver; Male; Mice; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1999 |
Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspases; Clofibrate; DDT; Dexamethasone; Dieldrin; Insulin; Liver Neoplasms, Experimental; NF-kappa B; Phenobarbital; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Time Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics | 1999 |
Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal epithelium: involvement of a cytochrome P-4504B1 isoform.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cell Hypoxia; Clofibrate; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA, Complementary; Epithelium, Corneal; Female; Isoenzymes; Lung; Male; Mixed Function Oxygenases; Molecular Sequence Data; Organ Culture Techniques; Phenobarbital; Polymerase Chain Reaction; Rabbits; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Stereoisomerism; Transcription, Genetic | 1999 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |
Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
Topics: Animals; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cell Line; Chromatography, High Pressure Liquid; Clofibrate; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Quinidine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sex Factors; Stereoisomerism | 2000 |
Cytochrome P450-dependent monooxygenase activities and their inducibility by classic P450 inducers in the liver, kidney, and nasal mucosa of male adult ring-necked pheasants.
Topics: Acetone; Animals; beta-Naphthoflavone; Birds; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Kidney; Microsomes, Liver; Nasal Mucosa; Phenobarbital | 2000 |
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Clofibrate; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dactinomycin; Deoxyadenosines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Alignment; Transcription, Genetic | 2001 |
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays.
Topics: Animals; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Energy Metabolism; Gene Expression Profiling; Liver; Male; Methylcholanthrene; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Stress, Physiological; Transcriptional Activation; Xenobiotics | 2001 |
Gene expression analysis reveals chemical-specific profiles.
Topics: Animals; Clofibrate; Computational Biology; DNA, Complementary; Gemfibrozil; Gene Expression; Gene Expression Profiling; Genomics; Liver; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Peroxisome Proliferators; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2002 |
Phylogenetic tree facilitates the understanding of gene expression data on drug metabolizing enzymes obtained by microarray analysis.
Topics: Administration, Oral; Animals; Base Sequence; Butylated Hydroxyanisole; Clofibrate; Cytochrome P-450 Enzyme System; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Phenobarbital; Phylogeny; Rats; Rats, Inbred F344; Xenobiotics | 2003 |
Effect of serum cholesterol on the mRNA content of amyloid precursor protein in rat livers.
Topics: Amyloid beta-Protein Precursor; Animals; Cholesterol; Cholesterol, Dietary; Clofibrate; Gene Expression; Liver; Male; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms; Male; Models, Biological; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Sex Characteristics; Substrate Specificity | 2007 |
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet.
Topics: Acetaminophen; Animals; Clofibrate; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Dietary Fats; Dietary Sucrose; Female; Glucuronosyltransferase; Jejunum; Liver; Male; Microsomes, Liver; Organic Anion Transporters; Phenanthrolines; Phenobarbital; PPAR alpha; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors | 2008 |
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Topics: Animals; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Enzyme Induction; Feasibility Studies; Isoenzymes; Liver; Male; Mice; Phenobarbital; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2008 |
Scoring multiple toxicological endpoints using a toxicogenomic database.
Topics: 2-Acetylaminofluorene; Acetaminophen; Algorithms; Animals; Biomarkers; Clofibrate; Data Interpretation, Statistical; Databases, Genetic; Endpoint Determination; Gene Expression; Liver; Male; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Toxicity Tests; Toxicogenetics | 2009 |
Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs.
Topics: Acyl-CoA Dehydrogenase; Animals; Carnitine O-Palmitoyltransferase; Clofibrate; Dogs; Electrophoresis, Gel, Two-Dimensional; Endoplasmic Reticulum, Smooth; Hepatomegaly; Liver; Male; Microscopy, Electron, Transmission; Mitochondria, Liver; Oligonucleotide Array Sequence Analysis; Phenobarbital; Proteomics | 2009 |
Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.
Topics: Animals; Clofibrate; Disease Models, Animal; Gene Expression; Hepatomegaly; Liver; Male; Oligonucleotide Array Sequence Analysis; Organ Size; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.
Topics: Animals; Cell Cycle Proteins; Clofibrate; Cytochrome P-450 Enzyme System; DNA Damage; Down-Regulation; Enzyme Induction; Gene Expression; Gene Expression Profiling; Hepatomegaly; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; Time Factors; Xenobiotics | 2011 |
Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats.
Topics: Animals; Carcinogens; CD36 Antigens; Clofibrate; Estrogen Receptor alpha; Female; Hepatomegaly; Leukemia Inhibitory Factor Receptor alpha Subunit; Liver; Male; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred F344; Receptors, Androgen; RNA, Messenger | 2012 |
Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells.
Topics: Animals; Carcinogens; Cell Line; Cell Movement; Clofibrate; Diethylnitrosamine; Epithelial Cells; Gene Expression Regulation; Liver Neoplasms, Experimental; Okadaic Acid; Phenobarbital; Rats; Rats, Inbred F344; Receptors, Lysophosphatidic Acid | 2016 |
Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice.
Topics: Animals; Cell Nucleus; Clofibrate; Hepatocytes; Hepatomegaly; Hypertrophy; Image Processing, Computer-Assisted; Liver; Male; Mice, Inbred Strains; Organ Size; Phenobarbital; Software | 2016 |
Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants.
Topics: Animals; Clofibrate; Cytochrome P-450 Enzyme System; DNA Methylation; Dose-Response Relationship, Drug; Epigenomics; Gene Expression; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344 | 2017 |
Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay.
Topics: Animals; Biological Assay; Carcinogens; Clofibrate; Glycosylphosphatidylinositols; Liver; Liver Neoplasms; Male; Mutagenicity Tests; Mutation; Phenobarbital; Pilot Projects; Rats; Rats, Inbred F344; Sensitivity and Specificity | 2019 |
Reduced hepatic global hydroxymethylation in mice treated with non-genotoxic carcinogens is transiently reversible with a methyl supplemented diet.
Topics: 5-Methylcytosine; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Carcinogenesis; Carcinogens; Clofibrate; Dietary Supplements; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Liver; Male; Methionine; Mice, Transgenic; Phenobarbital; Time Factors; Transcriptome | 2021 |