clofibrate and gemfibrozil

clofibrate has been researched along with gemfibrozil in 102 studies

Research

Studies (102)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (34.31)	18.7374
1990's	36 (35.29)	18.2507
2000's	19 (18.63)	29.6817
2010's	12 (11.76)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aizawa, Y; Fujita, T; Hasegawa, K; Horikoshi, H; Kanai, T; Kurumada, T; Yoshioka, T	1
Hirai, Y; Kawakami, M; Mishima, Y; Morishita, S; Saito, T; Shoji, M	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Chuang, S; Horne, J; Porter, CJ; Scanlon, MJ; Velkov, T	1
Abuo-Rahma, Gel-D; Aly, OM; Idrees, GA; Radwan, MF	1
Chalmers, DK; Chuang, S; Horne, J; Porter, CJ; Scanlon, MJ; Velkov, T; Wielens, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Fent, K; Popovic, M; Smital, T; Zaja, R	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Cai, J; Hu, X; Huang, M; Ji, M; Liu, W; Ning, Y; Ren, J; Wang, Y; Wei, L; Yu, P	1
Allen, CM; Henry, A; Stacpoole, PW	1
Colley, C; Lucas, LM; Magarian, GJ	1
Schwandt, P	1
Kłosiewicz-Latoszek, L; Szostak, WB	1
Hunninghake, DB	1
Aldini, R; Bazzoli, F; Festi, D; Mazzella, G; Roda, A; Roda, E; Simoni, P; Villanova, N	1
Feller, DR; Kocarek, TA	1
Frohlich, J; Hayden, M; Rabkin, SW	1
Islami, Y; Ribeiro, LG	1
Krause, BR; Newton, RS	1
Davignon, J; Roederer, G; Xhignesse, M	1
Kane, JP; Malloy, MJ	1
Naito, HK	1
Hunninghake, DB; Peters, JR	1
Grundy, SM; Vega, GL	1
Hirai, Y; Kawakami, M; Koyama, S; Mishima, Y; Mizutani, A; Morishita, S; Saito, T	1
Davignon, J	1
Blum, CB; Levy, RI	1
Nikkilä, EA; Tikkanen, MJ	1
Hirst, DG; Schwartz, HC; Wood, PJ	1
Perry, RS	1
Havel, RJ; Kane, JP	1
Malinow, MR	1
Gotto, AM; Jones, PH; Scott, LW	1
Oliver, MF	1
Santafé Oroz, J; Segarra Domènech, J	1
Grundy, SM; Kesäniemi, YA	1
Glueck, C	1
Maxwell, RE; Nawrocki, JW; Uhlendorf, PD	1
Nash, DT	2
Nye, ER; Sutherland, WH; Temple, Wa	1
Hall, MJ; Howard, AN; Nelson, LM; Russell, RI	1
Pickering, JE	1
Mälkönen, M; Manninen, V; Muona, M	1
Baldwin, LA; Calabrese, EJ; Donohue, M; Kostecki, PT; Leonard, DA	1
Adzet, T; Alegret, M; Cerqueda, E; Ferrando, R; Laguna, JC; Merlos, M; Sánchez, RM; Vázquez, M	1
Furberg, CD; Gould, AL; Heyse, JF; Rossouw, JE; Santanello, NC	1
Dujovne, CA; Lozada, A	1
Adzet, T; Alegret, M; Ferrando, R; Laguna, JC; Merlos, M; Vázquez, M	1
Welborn, TA	1
Betteridge, L; Chan, P; Gallagher, K; Munro, E; Patel, M; Schachter, M; Sever, P; Wolfe, J	1
Bays, H; Lansing, AM	1
Illingworth, DR; Larsen, ML; O'Malley, JP	1
Ades, EW; Lawley, TJ; Pruckler, JM	1
Auwerx, J; Grimaldi, P; Schoonjans, K; Staels, B	1
Accatino, L; Amigo, L; Andrade, L; Chianale, J; Gonzalez, S; Nervi, F; Pizarro, M; Rigotti, A; Vollrath, V; Wielandt, AM	1
Adzet, T; Alegret, M; Laguna, JC; Merlos, M; Muñoz, S; Vázquez, M	1
Juvonen, R; Kojo, A; Pasanen, M; Pelkonen, O; Pellinen, P; Raunio, H	1
Adzet, T; Alegret, M; Laguna, JC; López, M; Merlos, M; Rodríguez, C; Vázquez, M	1
Miller, CW; Ntambi, JM	1
Auerbach, BJ; Barnett, BC; DeMattos, RB; Essenburg, AD; Haubenwallner, S; Krause, BR; Leff, T; Minton, LL; Newton, RS; Pape, ME	1
Adzet, T; Laguna, JC; Merlos, M; Vázquez, M	1
Diemer, S; Eberlein-König, B; Przybilla, B	1
Bambauer, R; Müller, UA; Schiel, R	1
Amacher, DE; Beck, R; Kenny, CV; Schomaker, SJ	1
Farmer, JA; Gotto, AM	1
de Wit, EC; Huisman, H; Kaptein, A; Neele, DM; Princen, HM	1
Miller, DB; Spence, JD	1
Brewer, HB; Fruchart, JC; Leitersdorf, E	1
Kockx, M; Kooistra, T; Princen, HM	1
Wallace, KB; Zhou, S	1
Conney, AH; Xu, S; Zhu, BT	1
Afshari, CA; Barrett, JC; Bennett, L; Blanchard, K; Bushel, PR; DiSorbo, O; Hamadeh, HK; Jayadev, S; Martin, K; Paules, RS; Sieber, S; Stoll, R; Tennant, R	1
Bouzamondo, A; Corvol, JC; Hulot, JS; Lechat, P; Sanchez, P; Sirol, M	1
Fujisaki, K; Itoh, Y; Maiguma, T; Makino, K; Oishi, R; Sasaguri, T; Takahashi-Yanaga, F; Teshima, D	1
Hashimoto, F; Hayashi, H; Ikeda, M; Shiota, Y	1
Maki, KC	1
Agellon, LB; Gbaguidi, GF	1
Dobordzhginidze, LM; Gratsianskiĭ, NA	1
Baldwin, GS; Ford, J; Lachal, S; Shulkes, A	1
Hashimoto, F; Hayashi, H; Kimura, M; Matsuoka, K; Morita, M; Oguchi, Y; Takeda, S	1
Hwang, JW; Hwang, SY; Jeon, KS; Jung, JW; Kang, JS; Kang, KS; Kim, YS; Lee, GJ; Lee, WS; Lee, YS; Li, P; Oh, MJ; Park, JE; Park, JS; Song, BS; Um, CH; Yeo, CD; Youn, JP	1
Bloomfield, HE	1
Dellavalle, RP; Drake, AL; Freeman, SR; Graber, M; Heilig, LF; McNealy, K; Schilling, LM	1
Miyagishima, T; Nagao, T; Ono, A; Tamura, K; Urushidani, T	1
André, M; Babin, PJ; Raldúa, D	1
Fernandes, D; Porte, C; Schnell, S	1
Hao, Z; Liu, B; Liu, M; Tao, W; Wang, D	1

Reviews

24 review(s) available for clofibrate and gemfibrozil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Gemfibrozil-induced myopathy. Archives of internal medicine, 1991, Volume: 151, Issue:9 Topics: Clofibrate; Drug Therapy, Combination; Gemfibrozil; Humans; Hypertriglyceridemia; Lovastatin; Male; Middle Aged; Muscular Diseases	1991
Drug treatment of dyslipoproteinemia. Endocrinology and metabolism clinics of North America, 1990, Volume: 19, Issue:2 Topics: Bile Acids and Salts; Clofibrate; Coronary Disease; Drug Therapy, Combination; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemias; Hypolipoproteinemias; Niacin; Probucol	1990
Lipid lowering effects on cardiovascular morbidity and mortality. Clinical evidence and therapeutic guidelines. Arquivos brasileiros de cardiologia, 1988, Volume: 51, Issue:1 Topics: Cholesterol; Cholestyramine Resin; Clinical Trials as Topic; Clofibrate; Coronary Disease; Follow-Up Studies; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins; Male; Probucol; Triglycerides	1988
When to treat hyperlipidemia. Advances in internal medicine, 1988, Volume: 33 Topics: Animals; Arteriosclerosis; Cholesterol; Cholestyramine Resin; Clofibrate; Colestipol; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Neomycin; Niacin; Pentanoic Acids; Risk Factors; Triglycerides	1988
Reducing cardiac deaths with hypolipidemic drugs. Postgraduate medicine, 1987, Nov-01, Volume: 82, Issue:6 Topics: Cholesterol; Cholestyramine Resin; Clofibrate; Colestipol; Coronary Disease; Feeding Behavior; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Lipoproteins, LDL; Niacin; Patient Education as Topic; Pentanoic Acids; Probucol	1987
Effect of fibric acid derivatives on blood lipid and lipoprotein levels. The American journal of medicine, 1987, Nov-27, Volume: 83, Issue:5B Topics: Anticholesteremic Agents; Bezafibrate; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Pentanoic Acids	1987
Fibric acids: effects on lipids and lipoprotein metabolism. The American journal of medicine, 1987, Nov-27, Volume: 83, Issue:5B Topics: Bezafibrate; Bile Acids and Salts; Cholesterol; Clofibrate; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Pentanoic Acids; Triglycerides	1987
Contemporary recommendations for evaluating and treating hyperlipidemia. Clinical pharmacy, 1986, Volume: 5, Issue:2 Topics: Clofibrate; Dextrothyroxine; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Lipoproteins; Lovastatin; Naphthalenes; Neomycin; Niacin; Pentanoic Acids; Phenotype; Probucol	1986
Treatment of hypercholesterolemia. Annual review of medicine, 1986, Volume: 37 Topics: Animals; Cholestyramine Resin; Clofibrate; Colestipol; Cricetinae; Dogs; Drug Therapy, Combination; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Mice; Middle Aged; Neomycin; Niacin; Pentanoic Acids; Pregnancy; Probucol; Rats	1986
The diagnosis and management of hyperlipidemia. Disease-a-month : DM, 1986, Volume: 32, Issue:5 Topics: Adolescent; Adult; Child; Child, Preschool; Cholesterol; Cholestyramine Resin; Chylomicrons; Clofibrate; Colestipol; Coronary Disease; Dextrothyroxine; Dietary Fats; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type I; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Hyperlipoproteinemia Type IV; Hyperlipoproteinemia Type V; Lipoproteins; Lipoproteins, LDL; Neomycin; Niacin; Pentanoic Acids; Probucol; Receptors, LDL; Triglycerides	1986
[Pharmacologic therapy of atherosclerosis (I). Current possibilities]. Medicina clinica, 1983, Nov-26, Volume: 81, Issue:17 Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Clofibrate; Clofibric Acid; Fenofibrate; Gemfibrozil; Glycosaminoglycans; Humans; Ion Exchange Resins; Lipoproteins; Nicotinic Acids; Pentanoic Acids; Probucol	1983
Recommendations for treatment of hyperlipidemia in adults. A joint statement of the Nutrition Committee and the Council on Arteriosclerosis. Circulation, 1984, Volume: 69, Issue:5 Topics: Cholesterol; Clofibrate; Coronary Disease; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Lactation; Lipoproteins; Lovastatin; Naphthalenes; Niacin; Pentanoic Acids; Pregnancy; Pregnancy Complications; Probucol; Tangier Disease; Triglycerides	1984
Cholesterol reduction yields clinical benefit. A new look at old data. Circulation, 1995, Apr-15, Volume: 91, Issue:8 Topics: Cholesterol; Cholesterol, Dietary; Clofibrate; Coronary Disease; Dextrothyroxine; Estrogens; Gemfibrozil; Humans; Hypercholesterolemia; Male	1995
Drug interactions with fibric acids. Pharmacology & therapeutics, 1994, Volume: 63, Issue:2 Topics: Anticoagulants; Bezafibrate; Clofibrate; Clofibric Acid; Contraceptives, Oral; Coronary Disease; Drug Interactions; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Lipids	1994
Dyslipidaemia in non-insulin dependent diabetes: the need for a clinical intervention trial. Australian and New Zealand journal of medicine, 1994, Volume: 24, Issue:1 Topics: Cholesterol, HDL; Clinical Trials as Topic; Clofibrate; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Male; Risk Factors	1994
Choosing the right lipid-regulating agent. A guide to selection. Drugs, 1996, Volume: 52, Issue:5 Topics: Anticholesteremic Agents; Cholesterol, LDL; Cholestyramine Resin; Clofibrate; Colestipol; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Niacin; Triglycerides	1996
Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clinical pharmacokinetics, 1998, Volume: 34, Issue:2 Topics: Anticholesteremic Agents; Clofibrate; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver; Mixed Function Oxygenases; Warfarin	1998
Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate Consensus Group. The American journal of cardiology, 1998, Apr-01, Volume: 81, Issue:7 Topics: Animals; Cholesterol, LDL; Clofibrate; Coronary Disease; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Risk Factors	1998
Differential effects of lipid-lowering therapies on stroke prevention: a meta-analysis of randomized trials. Archives of internal medicine, 2003, Mar-24, Volume: 163, Issue:6 Topics: Anticholesteremic Agents; Atorvastatin; Cholestyramine Resin; Clofibrate; Colestipol; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Myocardial Infarction; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Regression Analysis; Risk Assessment; Risk Factors; Simvastatin; Stroke; Treatment Failure; Treatment Outcome	2003
Fibrates for treatment of the metabolic syndrome. Current atherosclerosis reports, 2004, Volume: 6, Issue:1 Topics: Cardiovascular Diseases; Clinical Trials as Topic; Clofibrate; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Metabolic Syndrome; Prevalence	2004
[Fibrates: mechanism of action, effect on levels of lipids and lipoproteins, risk of coronary events. Part 1. Clofibrate, gemfibrosil, besafibrate]. Kardiologiia, 2004, Volume: 44, Issue:2 Topics: Bezafibrate; Clofibrate; Female; Gemfibrozil; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Lipoproteins; Male; Randomized Controlled Trials as Topic	2004
Statins, fibrates, and melanoma risk: a systematic review and meta-analysis. Journal of the National Cancer Institute, 2006, Nov-01, Volume: 98, Issue:21 Topics: Atorvastatin; Bezafibrate; Clofibrate; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Incidence; Lovastatin; Melanoma; Odds Ratio; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Reproducibility of Results; Simvastatin; Skin Neoplasms; United States	2006
Fibrates for secondary prevention of cardiovascular disease and stroke. The Cochrane database of systematic reviews, 2015, Oct-25, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Bezafibrate; Cardiovascular Diseases; Cause of Death; Cholesterol, HDL; Clofibrate; Coronary Disease; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypertriglyceridemia; Male; Middle Aged; Myocardial Infarction; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke	2015

Trials

8 trial(s) available for clofibrate and gemfibrozil

Article	Year
Effect of gemfibrozil administration on biliary lipid secretion in hyperlipidemic patients. A crossover study with clofibrate. Scandinavian journal of gastroenterology, 1990, Volume: 25, Issue:12 Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholesterol; Clofibrate; Female; Gemfibrozil; Humans; Hyperlipidemias; Lipid Metabolism; Male; Middle Aged; Phospholipids	1990
Comparison of gemfibrozil and clofibrate on serum lipids in familial combined hyperlipidemia. A randomized placebo-controlled, double-blind, crossover clinical trial. Atherosclerosis, 1988, Volume: 73, Issue:2-3 Topics: Adult; Aged; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Clofibrate; Double-Blind Method; Female; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Lipids; Male; Middle Aged; Random Allocation; Triglycerides	1988
Lipid lowering effects on cardiovascular morbidity and mortality. Clinical evidence and therapeutic guidelines. Arquivos brasileiros de cardiologia, 1988, Volume: 51, Issue:1 Topics: Cholesterol; Cholestyramine Resin; Clinical Trials as Topic; Clofibrate; Coronary Disease; Follow-Up Studies; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins; Male; Probucol; Triglycerides	1988
Strategy, yield and risks of controlling plasma lipids in the primary prevention of coronary heart disease. Advances in experimental medicine and biology, 1985, Volume: 183 Topics: Adult; Arteriosclerosis; Cholesterol; Clinical Trials as Topic; Clofibrate; Coronary Disease; Diet; Gemfibrozil; Humans; Hypertension; Lipids; Male; Middle Aged; Pentanoic Acids; Risk; Smoking	1985
Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man. JAMA, 1984, May-04, Volume: 251, Issue:17 Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Clofibrate; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Pentanoic Acids; Steroids; Triglycerides; Valerates	1984
The treatment of hyperlipoproteinaemia with gemfibrozil compared with placebo and clofibrate. The New Zealand medical journal, 1980, Nov-12, Volume: 92, Issue:671 Topics: Adult; Aged; Cholesterol; Clofibrate; Female; Gemfibrozil; Humans; Hyperlipoproteinemias; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Pentanoic Acids; Placebos; Triglycerides; Valerates; Xylenes	1980
Gemfibrozil--the effect of biliary cholesterol saturation of a new lipid-lowering agent and its comparison with clofibrate. Atherosclerosis, 1981, Volume: 39, Issue:4 Topics: Bile; Cholesterol; Clofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Lipids; Male; Pentanoic Acids; Valerates; Xylenes	1981
Four years' treatment efficacy of patients with severe hyperlipidemia. Lipid lowering drugs versus LDL-apheresis. The International journal of artificial organs, 1995, Volume: 18, Issue:12 Topics: Adolescent; Adult; Anticholesteremic Agents; Blood Component Removal; Cholesterol, HDL; Cholesterol, LDL; Cholestyramine Resin; Clofibrate; Colestipol; Coronary Disease; Enzyme-Linked Immunosorbent Assay; Female; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Longitudinal Studies; Lovastatin; Male; Middle Aged; Niacin; Pravastatin; Quality of Life	1995

Other Studies

71 other study(ies) available for clofibrate and gemfibrozil

Article	Year
Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation. Journal of medicinal chemistry, 1989, Volume: 32, Issue:2 Topics: Animals; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Phenols; Rats; Structure-Activity Relationship	1989
Synthesis and hypolipidemic activity of 2-substituted isobutyric acid derivatives. Journal of medicinal chemistry, 1988, Volume: 31, Issue:6 Topics: Animals; Butyrates; Cholesterol; Clofibrate; Gemfibrozil; Hypolipidemic Agents; Isobutyrates; Male; Pentanoic Acids; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triglycerides	1988
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Characterization of the drug binding specificity of rat liver fatty acid binding protein. Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13 Topics: Anilino Naphthalenesulfonates; Animals; Fatty Acid-Binding Proteins; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Fluorescence; Substrate Specificity	2008
Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives. European journal of medicinal chemistry, 2009, Volume: 44, Issue:6 Topics: Animals; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Drug Design; Gemfibrozil; Hypolipidemic Agents; Male; Molecular Structure; Propionates; Rats; Rats, Wistar; Stereoisomerism; Triglycerides	2009
Probing the fibrate binding specificity of rat liver fatty acid binding protein. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Animals; Binding Sites; Carboxylic Acids; Clofibric Acid; Esters; Fatty Acid-Binding Proteins; Fenofibrate; Hypolipidemic Agents; Ligands; Liver; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Rats; Spectrometry, Fluorescence; Substrate Specificity; Temperature; Thermodynamics	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide. The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47 Topics: Animals; Evolution, Molecular; Glycosylation; Gonadal Steroid Hormones; HEK293 Cells; Humans; Ion Transport; Organic Anion Transporters; Protein Multimerization; Zebrafish; Zebrafish Proteins	2013
Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208. Bioorganic & medicinal chemistry letters, 2019, 08-15, Volume: 29, Issue:16 Topics: Cell Cycle Proteins; Humans; Hypolipidemic Agents; Transcription Factors	2019
Fibric acid derivatives: effects on the synthesis of isoprenoid lipids in cultured human lymphocytes. Biochimica et biophysica acta, 1992, Jul-29, Volume: 1127, Issue:2 Topics: Acetates; Cell Division; Cholesterol; Clofibrate; Dolichols; Gemfibrozil; Humans; Lymphocytes; Mevalonic Acid; Tumor Cells, Cultured; Ubiquinone	1992
Choice of cholesterol-lowering drugs. The Medical letter on drugs and therapeutics, 1991, Jan-11, Volume: 33, Issue:835 Topics: Anticholesteremic Agents; Cholestyramine Resin; Clofibrate; Colestipol; Fish Oils; Gemfibrozil; Humans; Lovastatin; Neomycin; Niacin; Probucol	1991
Fibrates and triglyceride metabolism. European journal of clinical pharmacology, 1991, Volume: 40 Suppl 1 Topics: Bezafibrate; Clofibrate; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Triglycerides	1991
Comparative studies on the influence of different fibrates on serum lipoproteins in endogenous hyperlipoproteinaemia. European journal of clinical pharmacology, 1991, Volume: 40, Issue:1 Topics: Adult; Aged; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Colestipol; Female; Fenofibrate; Gemfibrozil; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Probucol	1991
Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes. Biochemical pharmacology, 1989, Dec-01, Volume: 38, Issue:23 Topics: Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fibric Acids; Gemfibrozil; Kinetics; Liver; Microbodies; Mixed Function Oxygenases; Oxidoreductases; Rats; Triglycerides	1989
Gemfibrozil increases both apo A-I and apo E concentrations. Comparison to other lipid regulators in cholesterol-fed rats. Atherosclerosis, 1986, Volume: 59, Issue:1 Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Bezafibrate; Cholesterol, Dietary; Cholesterol, HDL; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Male; Pentanoic Acids; Rats; Rats, Inbred Strains; Valerates	1986
Eruptive and tubero-eruptive xanthomas of the skin arising on sites of prior injury. Two case reports. JAMA, 1988, Sep-02, Volume: 260, Issue:9 Topics: Adult; Clofibrate; Female; Gemfibrozil; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged; Pentanoic Acids; Skin; Skin Diseases; Xanthomatosis	1988
[Strains and species differences in experimental hyperlipidemia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 87, Issue:3 Topics: Animals; Clofibrate; Disease Models, Animal; Gemfibrozil; Glycerides; Hyperlipidemias; Hypolipidemic Agents; Lipids; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Niacin; Pentanoic Acids; Pyridines; Rats; Rats, Inbred Strains; Species Specificity	1986
Medical management of hyperlipidemia and the role of probucol. The American journal of cardiology, 1986, Jun-27, Volume: 57, Issue:16 Topics: Adult; Arteriosclerosis; Cholesterol, LDL; Cholestyramine Resin; Clofibrate; Colestipol; Female; Gemfibrozil; Humans; Hyperlipidemias; Hyperlipoproteinemia Type II; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Middle Aged; Niacin; Pentanoic Acids; Phenols; Probucol; Risk	1986
Rational drug therapy of the hyperlipoproteinemias, Part II. Rational drug therapy, 1986, Volume: 20, Issue:10 Topics: Cholestyramine Resin; Clofibrate; Colestipol; Dextrothyroxine; Female; Fish Oils; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemias; Hypolipidemic Agents; Male; Neomycin; Niacin; Pentanoic Acids; Probucol	1986
Current pharmacologic treatment of elevated serum cholesterol. Circulation, 1987, Volume: 76, Issue:3 Topics: Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Clofibrate; Colestipol; Drug Tolerance; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Naphthalenes; Neomycin; Niacin; Pentanoic Acids; Probucol; Simvastatin; Triglycerides	1987
The modification of hemoglobin affinity for oxygen and tumor radiosensitivity by antilipidemic drugs. Radiation research, 1987, Volume: 112, Issue:1 Topics: Animals; Bezafibrate; Clofibrate; Combined Modality Therapy; Gemfibrozil; Hemoglobins; Hypolipidemic Agents; Mice; Neoplasm Transplantation; Oxygen; Pentanoic Acids; Radiation-Sensitizing Agents; Sarcoma, Experimental	1987
Adverse effects of the treatment for hyperlipidemia. Cardiology clinics, 1986, Volume: 4, Issue:1 Topics: Anion Exchange Resins; Anticholesteremic Agents; Bibliographies as Topic; Clofibrate; Diet; Drug Therapy, Combination; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Neomycin; Niacin; Pentanoic Acids; Physical Exertion; Probucol; Risk	1986
Addition to labeling of cholestyramine. FDA drug bulletin, 1985, Volume: 15, Issue:1 Topics: Cholestyramine Resin; Clofibrate; Diet Therapy; Drug Labeling; Gemfibrozil; Humans; Hypolipidemic Agents; Niacin; Pentanoic Acids; Probucol; Thyroxine; United States; United States Food and Drug Administration	1985
Lipid-lowering drugs. The Medical letter on drugs and therapeutics, 1985, Aug-30, Volume: 27, Issue:695 Topics: Anticholesteremic Agents; Cholestyramine Resin; Clofibrate; Colestipol; Dextrothyroxine; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins; Neomycin; Niacin; Pentanoic Acids; Probucol; Triglycerides	1985
Influence of clofibrate, bile-sequestering agents and probucol on high-density lipoprotein levels. The American journal of cardiology, 1983, Aug-22, Volume: 52, Issue:4 Topics: Bile Acids and Salts; Clofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins; Lipoproteins, HDL; Nicotinic Acids; Pentanoic Acids; Phenols; Probucol	1983
Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats. Atherosclerosis, 1983, Volume: 48, Issue:3 Topics: Animals; Anticholesteremic Agents; Bezafibrate; Caprylates; Carbon Radioisotopes; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Clofibrate; Gemfibrozil; Hypolipidemic Agents; Liver; Lovastatin; Male; Mevalonic Acid; Naphthalenes; Pentanoic Acids; Rats; Rats, Inbred F344; Sterols; Valerates	1983
Consensus conference: Treatment of hypertriglyceridemia. JAMA, 1984, Mar-02, Volume: 251, Issue:9 Topics: Body Weight; Cardiovascular Diseases; Clofibrate; Gemfibrozil; Humans; Hyperlipidemias; Hyperlipoproteinemias; Hypolipidemic Agents; National Institutes of Health (U.S.); Pentanoic Acids; Triglycerides; United States	1984
Hyperlipidemia: reducing the chances of cardiovascular disease. Geriatrics, 1984, Volume: 39, Issue:7 Topics: Cholesterol; Cholestyramine Resin; Clofibrate; Coronary Disease; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Pentanoic Acids; Probucol; Triglycerides	1984
Gemfibrozil--a new lipid lowering agent. Journal of medicine, 1980, Volume: 11, Issue:2-3 Topics: Cholesterol; Clofibrate; Dose-Response Relationship, Drug; Double-Blind Method; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type IV; Hypolipidemic Agents; Pentanoic Acids; Triglycerides; Valerates; Xylenes	1980
Nutritional & pharmacologic management of hyperlipoproteinemia. Angiology, 1982, Volume: 33, Issue:9 Topics: Cholesterol; Cholesterol, Dietary; Clofibrate; Dietary Fats; Gemfibrozil; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins, VLDL; Pentanoic Acids; Valerates	1982
Studies on hypoxic dyslipidaemia. Effect of lipid modulating drugs. Acta medica Scandinavica. Supplementum, 1982, Volume: 668 Topics: Altitude; Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibrate; Decompression; Female; Gemfibrozil; Hyperlipidemias; Hypolipidemic Agents; Hypoxia; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Nicotinic Acids; Pentanoic Acids; Rats; Rats, Inbred Strains; Triglycerides	1982
Effect of hypolipidemic drugs gemfibrozil, ciprofibrate, and clofibric acid on peroxisomal beta-oxidation in primary cultures of rainbow trout hepatocytes. Ecotoxicology and environmental safety, 1993, Volume: 26, Issue:2 Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enoyl-CoA Hydratase; Enzyme Activation; Fibric Acids; Gemfibrozil; Hypolipidemic Agents; Isomerases; Liver; Male; Microbodies; Multienzyme Complexes; Oncorhynchus mykiss; Oxidation-Reduction; Oxidoreductases; Peroxisomal Bifunctional Enzyme	1993
Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation. British journal of pharmacology, 1995, Volume: 114, Issue:7 Topics: Acetyltransferases; Animals; Bezafibrate; Clofibrate; Dietary Fats; Fatty Acid Desaturases; Fatty Acid Elongases; Fatty Acids; Gemfibrozil; Male; Microbodies; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Time Factors	1995
Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates. British journal of pharmacology, 1994, Volume: 112, Issue:2 Topics: Animals; Bezafibrate; Cholesterol; Clofibrate; Coenzyme A Ligases; Diet; Gemfibrozil; Hypolipidemic Agents; Lipids; Liver; Male; Microbodies; Organ Size; Palmitoyl-CoA Hydrolase; Rats; Rats, Sprague-Dawley; Repressor Proteins; Saccharomyces cerevisiae Proteins; Triglycerides	1994
Growth inhibition of human vascular smooth muscle cells by fenofibrate: a possible therapy for restenosis. Cardiovascular research, 1994, Volume: 28, Issue:5 Topics: Bezafibrate; Cell Division; Cells, Cultured; Clofibrate; Fenofibrate; Gemfibrozil; Graft Occlusion, Vascular; Humans; Muscle, Smooth; Platelet-Derived Growth Factor; Saphenous Vein	1994
Fish oil (omega-3 fatty acids) in treatment of hypertriglyceridemia. A practical approach for the primary care physician. The Journal of the Kentucky Medical Association, 1994, Volume: 92, Issue:3 Topics: Aged; Clofibrate; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Gemfibrozil; Humans; Hypertriglyceridemia; Lipids; Lovastatin; Niacin; Primary Health Care	1994
Comparative effects of gemfibrozil and clofibrate in type III hyperlipoproteinemia. Atherosclerosis, 1994, Volume: 106, Issue:2 Topics: Adult; Aged; Cholesterol; Clofibrate; Female; Gemfibrozil; Humans; Hyperlipoproteinemia Type III; Lipoproteins, VLDL; Male; Middle Aged; Retrospective Studies; Triglycerides	1994
Use of a human microvascular endothelial cell line as a model system to evaluate cholesterol uptake. Pathobiology : journal of immunopathology, molecular and cellular biology, 1993, Volume: 61, Issue:5-6 Topics: Biological Transport; Cells, Cultured; Cholesterol; Cholestyramine Resin; Clofibrate; Endothelium, Vascular; Gemfibrozil; Humans; Models, Biological; Probucol; Tritium	1993
Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation. European journal of biochemistry, 1993, Sep-01, Volume: 216, Issue:2 Topics: Adipose Tissue; Animals; Clofibrate; Coenzyme A Ligases; Diet; Fenofibrate; Gemfibrozil; Gene Expression Regulation, Enzymologic; Glucocorticoids; Heart; Kidney; Liver; Liver Neoplasms, Experimental; Male; Mice; Microbodies; Myocardium; Oxidation-Reduction; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Tumor Cells, Cultured	1993
Choice of cholesterol-lowering drugs. The Medical letter on drugs and therapeutics, 1993, Mar-05, Volume: 35, Issue:891 Topics: Anticholesteremic Agents; Cholestyramine Resin; Clofibrate; Colestipol; Fish Oils; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Niacin; Probucol	1993
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse. The Biochemical journal, 1996, Mar-15, Volume: 314 ( Pt 3) Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Bezafibrate; Bile; Bile Canaliculi; Clofibrate; Clofibric Acid; DNA Primers; Drug Resistance, Multiple; Fenofibrate; Fibric Acids; Gemfibrozil; Gene Expression; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Multigene Family; Phospholipids; RNA, Messenger; RNA, Ribosomal, 18S	1996
Differential effects of fibrates on the acyl composition of microsomal phospholipids in rats. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: Animals; Bezafibrate; Cell Division; Clofibrate; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Gemfibrozil; Hypolipidemic Agents; Lipids; Liver; Male; Microbodies; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Sprague-Dawley; Time Factors	1995
Distinct responses of mouse hepatic CYP enzymes to corn oil and peroxisome proliferators. Biochemical pharmacology, 1996, May-03, Volume: 51, Issue:9 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clofibrate; Corn Oil; Cytochrome P-450 Enzyme System; Gemfibrozil; Male; Mice; Mice, Inbred DBA; Microbodies; Microsomes, Liver; Steroid Hydroxylases	1996
Different effects of fibrates on the microsomal fatty acid chain elongation and the acyl composition of phospholipids in guinea-pigs. British journal of pharmacology, 1995, Volume: 116, Issue:8 Topics: Animals; Bezafibrate; Clofibrate; Fatty Acid Synthases; Fatty Acids; Gemfibrozil; Guinea Pigs; Hypolipidemic Agents; Male; Microsomes, Liver; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Palmitoyl-CoA Hydrolase; Phospholipids	1995
Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proceedings of the National Academy of Sciences of the United States of America, 1996, Sep-03, Volume: 93, Issue:18 Topics: Animals; Arachidonic Acid; Base Sequence; Chloramphenicol O-Acetyltransferase; Clofibrate; Cycloheximide; Fatty Acids, Unsaturated; Gemfibrozil; Gene Expression Regulation, Enzymologic; Liver; Mice; Mice, Inbred BALB C; Microbodies; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stearoyl-CoA Desaturase; Transcription Factors; Transcription, Genetic	1996
Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action. Journal of lipid research, 1995, Volume: 36, Issue:12 Topics: Animals; Apolipoprotein C-III; Apolipoproteins C; Bezafibrate; Cholesterol; Clofibrate; Fenofibrate; Gemfibrozil; Hypolipidemic Agents; Liver; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides	1995
Decreased susceptibility to copper-induced oxidation of rat-lipoproteins after fibrate treatment: influence of fatty acid composition. British journal of pharmacology, 1996, Volume: 117, Issue:6 Topics: Animals; Antioxidants; Bezafibrate; Clofibrate; Copper Sulfate; Fatty Acids; Gemfibrozil; Hypolipidemic Agents; Lipid Peroxidation; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Rats; Rats, Sprague-Dawley	1996
Evaluation of the phototoxic properties of some hypolipidemics in vitro: fenofibrate exhibits a prominent phototoxic potential in the UVA and UVB region. Journal of dermatological science, 1996, Volume: 13, Issue:2 Topics: Bezafibrate; Clofibrate; Dermatitis, Phototoxic; Drug Evaluation, Preclinical; Fenofibrate; Gemfibrozil; Hemolysis; Humans; Hypolipidemic Agents; In Vitro Techniques; Ultraviolet Rays	1996
Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat. Toxicology and applied pharmacology, 1997, Volume: 142, Issue:1 Topics: Animals; Anticholesteremic Agents; Bezafibrate; Clofibrate; Cyclin-Dependent Kinases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gemfibrozil; Isoenzymes; Liver; Male; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxidation-Reduction; Palmitoyl Coenzyme A; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred Strains; Sex Characteristics	1997
No effect of fibrates on synthesis of apolipoprotein(a) in primary cultures of cynomolgus monkey and human hepatocytes: apolipoprotein A-I synthesis increased. Biochemical and biophysical research communications, 1998, Mar-17, Volume: 244, Issue:2 Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Bezafibrate; Cells, Cultured; Clofibrate; Clofibric Acid; Gemfibrozil; Humans; Liver; Macaca fascicularis	1998
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha. Thrombosis and haemostasis, 1998, Volume: 80, Issue:6 Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin	1998
The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 48, Issue:1 Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene	1999
Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:1 Topics: Acyltransferases; Animals; Catalysis; Chromatography, High Pressure Liquid; Clofibrate; Diet; Esters; Estradiol; Fatty Acids; Female; Gemfibrozil; Hydrogen-Ion Concentration; Hypolipidemic Agents; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Stearoyl-CoA Desaturase; Stimulation, Chemical	2001
Cholesterol-lowering drugs. Some drugs with demonstrated efficacy but different benefits in primary and secondary prevention. Prescrire international, 1999, Volume: 8, Issue:42 Topics: Anticholesteremic Agents; Bezafibrate; Cholestyramine Resin; Clinical Trials as Topic; Clofibrate; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Myocardial Infarction; Pravastatin; Treatment Outcome	1999
Gene expression analysis reveals chemical-specific profiles. Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 67, Issue:2 Topics: Animals; Clofibrate; Computational Biology; DNA, Complementary; Gemfibrozil; Gene Expression; Gene Expression Profiling; Genomics; Liver; Male; Oligonucleotide Array Sequence Analysis; Pattern Recognition, Automated; Peroxisome Proliferators; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2002
Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells. Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:3 Topics: Bezafibrate; Clofibrate; Clofibric Acid; Disease Models, Animal; Drug Synergism; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma, Embryonal; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Tumor Cells, Cultured	2003
Effects of peroxisome proliferators gemfibrozil and clofibrate on syntheses of dolichol and cholesterol in rat liver. Journal of biochemistry, 2003, Volume: 134, Issue:2 Topics: Acetates; Animals; Carbon Radioisotopes; Cholesterol; Clofibrate; Dolichol Phosphates; Dolichols; Gemfibrozil; Liver; Male; Mevalonic Acid; Peroxisome Proliferators; Polyisoprenyl Phosphates; Rats; Rats, Wistar; Sesquiterpenes; Tritium	2003
The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer. Nucleic acids research, 2004, Volume: 32, Issue:3 Topics: Acids, Acyclic; Animals; Bezafibrate; Binding Sites; Cell Line, Tumor; Cells, Cultured; Cholesterol 7-alpha-Hydroxylase; Clofibrate; Dimerization; DNA-Binding Proteins; Gemfibrozil; Gene Expression Regulation; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hydroxycholesterols; Ligands; Liver X Receptors; Nuclear Proteins; Orphan Nuclear Receptors; Promoter Regions, Genetic; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Repetitive Sequences, Nucleic Acid; Response Elements; Transcription Factors	2004
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells. Regulatory peptides, 2004, Aug-15, Volume: 120, Issue:1-3 Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents	2004
PPARalpha agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells. Biochemical pharmacology, 2004, Jul-15, Volume: 68, Issue:2 Topics: Anticholesteremic Agents; Cell Division; Chorionic Gonadotropin; Clofibrate; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Gemfibrozil; Humans; L-Lactate Dehydrogenase; Peroxisomes; Progesterone; Receptors, Cytoplasmic and Nuclear; Subcellular Fractions; Transcription Factors; Trophoblasts; Tumor Cells, Cultured; Up-Regulation	2004
Gene expression analysis of peroxisome proliferators- and phenytoin-induced hepatotoxicity using cDNA microarray. The Journal of veterinary medical science, 2004, Volume: 66, Issue:11 Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Clofibrate; Dose-Response Relationship, Drug; Gemfibrozil; Gene Expression Profiling; Gene Expression Regulation; Liver; Male; Oligonucleotide Array Sequence Analysis; Peroxisomes; Phenytoin; Rats; Rats, Sprague-Dawley	2004
The role of fibrates in a statin world. Archives of internal medicine, 2006, Apr-10, Volume: 166, Issue:7 Topics: Clofibrate; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Peroxisome Proliferator-Activated Receptors	2006
Profiling of gene expression in rat liver and rat primary cultured hepatocytes treated with peroxisome proliferators. The Journal of toxicological sciences, 2006, Volume: 31, Issue:5 Topics: Alanine Transaminase; Animals; Cells, Cultured; Clofibrate; Cluster Analysis; Databases, Factual; Gemfibrozil; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Liver; Male; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; PPAR alpha; Principal Component Analysis; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triglycerides	2006
Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. Toxicology and applied pharmacology, 2008, May-01, Volume: 228, Issue:3 Topics: Animals; Bone and Bones; Clofibrate; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Gemfibrozil; Hypolipidemic Agents; Larva; Lipid Metabolism; Neuromuscular Junction; PPAR alpha; RNA, Messenger; Zebrafish	2008
Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study. Marine pollution bulletin, 2011, Volume: 62, Issue:10 Topics: Androgens; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Biomarkers; Carps; Clofibrate; Clofibric Acid; Diclofenac; Fibric Acids; Fluoxetine; Gemfibrozil; Ibuprofen; Male; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Testis; Water Pollutants, Chemical	2011