Compounds > clofibrate

clofibrate and dactinomycin

clofibrate has been researched along with dactinomycin in 10 studies

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dalton, C; Hope, HR; Hope, WC; Sheppard, H	1
Jahr, H; Kohnert, KD; Kruschel, B; Walter, BM	1
Edwards, RJ; Guengerich, FP; Hollenberg, PF; Kim, H; Novak, RF; Putt, DA; Wolf, CR; Zangar, RC	1
Bastin, J; Djouadi, F; Ouali, F	1
Chichester, CO; Deng, R; Li, Y; Liu, J; Ma, Y; Sachdeva, K; Song, X; Yan, B; Yang, D	1

Reviews

1 review(s) available for clofibrate and dactinomycin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

9 other study(ies) available for clofibrate and dactinomycin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Relationship of serum triglyceride lowering to changes in hepatic composition induced by different classes of drugs. Biochemical pharmacology, 1974, Feb-01, Volume: 23, Issue:3 Topics: Animals; Cholesterol; Clofibrate; Dactinomycin; DNA; Dose-Response Relationship, Drug; Glycolates; Hepatomegaly; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Nafenopin; Oxidoreductases, N-Demethylating; Phenobarbital; Phenyl Ethers; Phenytoin; Phospholipids; Piperazines; Piperidines; Propionates; Proteins; Rats; RNA; Spectrophotometry, Ultraviolet; Triglycerides	1974
Complement-mediated cytotoxic effects of islet cell surface antibodies: factors influencing the sensitivity of the target cells. Biomedica biochimica acta, 1984, Volume: 43, Issue:5 Topics: Animals; Clofibrate; Complement System Proteins; Cytotoxicity, Immunologic; Dactinomycin; Diabetes Mellitus, Type 1; Humans; In Vitro Techniques; Islets of Langerhans; Lipids; Male; Rats; Rats, Inbred Strains	1984
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Clofibrate; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dactinomycin; Deoxyadenosines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Alignment; Transcription, Genetic	2001
Effects of fatty acids on mitochondrial beta-oxidation enzyme gene expression in renal cell lines. American journal of physiology. Renal physiology, 2002, Volume: 283, Issue:2 Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenase, Long-Chain; Animals; Caprylates; Cell Line, Transformed; Clofibrate; Dactinomycin; Dose-Response Relationship, Drug; Fatty Acids; Gene Expression Regulation, Enzymologic; Hypolipidemic Agents; Kidney Tubules; Laurates; Lipid Metabolism; Mitochondria; Oleic Acid; Palmitates; Protein Synthesis Inhibitors; Rabbits; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors	2002
Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23. Biochemical pharmacology, 2005, May-01, Volume: 69, Issue:9 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cells, Cultured; Clofibrate; Cytochrome P-450 CYP3A; Dactinomycin; Decanoic Acids; Fluorocarbons; Hepatocytes; Ligands; Male; Pregnane X Receptor; Pregnenolone Carbonitrile; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Up-Regulation	2005