Compounds > clofarabine
Page last updated: 2024-09-03

clofarabine and cyclosporine

clofarabine has been researched along with cyclosporine in 5 studies

Compound Research Comparison

Studies
(clofarabine)		Trials
(clofarabine)		Recent Studies (post-2010)
(clofarabine)		Studies
(cyclosporine)		Trials
(cyclosporine)		Recent Studies (post-2010) (cyclosporine)
4241012803772170
42410128030,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomyclofarabine (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Beutel, G; Buchholz, S; Dammann, E; Eder, M; Ganser, A; Krauter, J; Stadler, M; Trummer, A1
Claxton, D; Ehmann, WC; Karch, J; Zhu, J1

Reviews

1 review(s) available for clofarabine and cyclosporine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for clofarabine and cyclosporine

ArticleYear
Cytoreductive treatment with clofarabine/ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome.
    European journal of haematology, 2012, Volume: 88, Issue:1

    Topics: Adenine Nucleotides; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Clofarabine; Cyclosporine; Cytarabine; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Middle Aged; Mycophenolic Acid; Myelodysplastic Syndromes; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Transplantation Conditioning; Transplantation, Homologous

2012
Clofarabine and CY do not yield reliable engraftment of hematopoietic stem cells.
    Bone marrow transplantation, 2012, Volume: 47, Issue:8

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clofarabine; Cyclosporine; Female; Graft Survival; Hematologic Neoplasms; Humans; Immunosuppressive Agents; Male; Peripheral Blood Stem Cell Transplantation; Transplantation, Homologous

2012

Other Studies

2 other study(ies) available for clofarabine and cyclosporine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013