clofarabine has been researched along with cladribine in 34 studies
| Studies (clofarabine) | Trials (clofarabine) | Recent Studies (post-2010) (clofarabine) | Studies (cladribine) | Trials (cladribine) | Recent Studies (post-2010) (cladribine) |
|---|---|---|---|---|---|
| 424 | 101 | 280 | 1,789 | 258 | 621 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 13 (38.24) | 24.3611 |
| 2020's | 5 (14.71) | 2.80 |
| Authors | Studies |
|---|---|
| Clayton, SD; Montgomery, JA; Riordan, JM; Secrist, JA; Shortnacy-Fowler, AT | 1 |
| Ameral, R; Birkus, G; Cihlar, T; Dzubák, P; Hajdúch, M; Hocek, M; Mackman, R; Naus, P; Pohl, R; Ray, AS; Votruba, I; Wang, T | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Benfenati, E; Raska, I; Toropov, AA; Toropova, AP | 1 |
| Birkus, G; Bourderioux, A; Cihlar, T; Dzubák, P; Feng, JY; Hajdúch, M; Hocek, M; Konecný, P; Naus, P; Perlíková, P; Pichová, I; Pohl, R; Ray, AS; Stray, KM; Votruba, I; Wang, T | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Huang, Y; Li, J; Luo, HB; Mao, F; Qiu, X; Wu, D; Yan, W; Zhu, J | 1 |
| Carrera, CJ; Carson, DA; Cottam, HB; Esparza, LM; Kipps, TJ; Wasson, DB | 1 |
| Albertioni, F; Liliemark, J; Lindemalm, S | 1 |
| Albertioni, F; Eriksson, S; Hullán, L; Sasvári-Székely, M; Spasokoukotskaja, T; Staub, M | 1 |
| Albertioni, F; Liliemark, J; Reichelova, V | 1 |
| Albertioni, F; De Abreu, RA; Leegwater, PA | 1 |
| Albertioni, F; Eriksson, S; Liliemark, J; Lotfi, K; Månsson, E; Peterson, C; Pettersson, B; Spasokoukotskaja, T | 1 |
| Albertioni, F; Larsson, BS; Liliemark, J; Lindemalm, S | 1 |
| Adachi, S; Carrera, CJ; Carson, DA; Chao, Q; Cottam, HB; Genini, D; Leoni, LM; Rose, DW | 1 |
| Albertioni, F; Elford, H; Eriksson, S; Flordal, E; Lagercrantz, S; Liliemark, J; Månsson, E; Spasokoukotskaja, T | 1 |
| Albertioni, F; Eriksson, S; Gruber, A; Karlsson, MO; Liliemark, J; Lindemalm, S; Wang, Y | 1 |
| Cass, CE; Damaraju, VL; King, KM; Lang, T; Mowles, DA; Ng, AM; Tackaberry, TE; Vickers, MF; Yao, SY; Young, JD | 1 |
| Duncan, CJ; Hsieh, Y; Lee, S; Liu, M | 1 |
| Chen, LS; Gandhi, V; Plunkett, W | 1 |
| Beijnen, J; Borst, P; de Haas, M; de Wolf, C; Jansen, R; van de Wetering, K; Wijnholds, J; Yamaguchi, H | 1 |
| Bagley, RG; Crawford, J; Krumbholz, R; Kurtzberg, LS; Lovett, D; Roth, S; Rouleau, C; Schmid, S; Teicher, BA; Yao, M | 1 |
| Jacobson, PA; Jensen, K; Johnson, LA; Kachler, S; Kirstein, MN; Klotz, KN; Lamba, J | 1 |
| Fukuda, Y; Schuetz, JD | 1 |
| Andersson, BS; Champlin, RE; Ji, J; Li, Y; Liu, Y; Murray, D; Popat, U; Valdez, BC | 1 |
| Goto, H; Goto, S; Yokosuka, T | 1 |
| Cros-Perrial, E; Dumontet, C; Jordheim, LP; Lefebvre-Tournier, I; Peyrottes, S; Puy, JY | 1 |
| Bates, J; Buhlinger, K; Deal, AM; Foster, MC; Jamieson, KJ; Muluneh, B; Van Deventer, HW; Zeidner, JF | 1 |
| Bonar, F; Boyle, R; Brown, W; Khoo, TL; Othman, J | 1 |
| Cervantes-Ríos, E; Cruz-Vallejo, V; Morales-Ramírez, P; Ortíz-Muñiz, R; Quezada-Vidal, J | 1 |
| Gulati, N | 1 |
| Borthakur, G; Burger, J; Daver, N; DiNardo, CD; Estrov, Z; Ferrajoli, A; Garcia-Manero, G; Huang, X; Jabbour, E; Jain, N; Kadia, TM; Kanagal-Shamanna, R; Kantarjian, H; Konopleva, M; Pemmaraju, N; Pierce, S; Popat, U; Rausch, C; Ravandi, F; Verstovsek, S; Wang, X | 1 |
| Atasoy, S; Balaraman, K; Deniz, E; Molotkova, A; Nelson, E; Pilicer, SL; Sevim, H; Tiwari, PB; Üren, A; Wolf, C | 1 |
2 review(s) available for clofarabine and cladribine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
ABC transporters and their role in nucleoside and nucleotide drug resistance.
Topics: Adenine Nucleotides; Arabinonucleosides; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cladribine; Clofarabine; Cytarabine; Drug Resistance; Humans; Neoplasm Proteins; Nucleosides; Nucleotides; Polymorphism, Single Nucleotide | 2012 |
32 other study(ies) available for clofarabine and cladribine
| Article | Year |
|---|---|
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
Topics: Animals; Antimetabolites, Antineoplastic; Escherichia coli; HIV; Humans; Leukemia P388; Mice; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Tumor Cells, Cultured; Vidarabine | 1992 |
6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytostatic Agents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Purines; Ribonucleosides; Stereoisomerism; Structure-Activity Relationship | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water | 2010 |
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Topics: Adenosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cytostatic Agents; Humans; Mice; RNA Polymerase II; Tubercidin | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation.
Topics: Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Humans; Models, Molecular; Molecular Structure; Nucleosides; Phosphodiesterase Inhibitors; Purines; Structure-Activity Relationship | 2018 |
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
Topics: 2-Chloroadenosine; Adenine Nucleotides; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Death; Cladribine; Clofarabine; Deoxyadenosines; DNA; DNA Damage; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Mice; Mice, SCID; Monocytes | 1992 |
Stability and analysis of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine and 2-chloroadenine in human blood plasma.
Topics: Adenine; Adenine Nucleotides; Aged; Antineoplastic Agents; Arabinonucleosides; Chromatography, High Pressure Liquid; Cladribine; Clofarabine; Female; Humans; Male; Middle Aged; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1997 |
Activation of deoxycytidine kinase by various nucleoside analogues.
Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Cycle; Cells, Cultured; Cladribine; Clofarabine; Cytarabine; Deoxycytidine Kinase; Enzyme Activation; HL-60 Cells; Humans; Leukemia; Lymphocytes; Palatine Tonsil; Thymidine Kinase; Tumor Cells, Cultured; Vidarabine | 1998 |
Liquid chromatographic study of acid stability of 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine and related analogues.
Topics: Adenine Nucleotides; Arabinonucleosides; Chromatography, Liquid; Cladribine; Clofarabine; Half-Life; Hydrogen-Ion Concentration | 1995 |
Analysis of DNA methylation of the 5' region of the deoxycytidine kinase gene in CCRF-CEM-sensitive and cladribine (CdA)- and 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine (CAFdA)-resistant cells.
Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Base Sequence; Cladribine; Clofarabine; Deoxycytidine Kinase; DNA Methylation; Drug Resistance, Neoplasm; Humans; Leukemia, T-Cell; Molecular Sequence Data; Neoplasm Proteins; Tumor Cells, Cultured | 1998 |
Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells.
Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cladribine; Clofarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Phosphorylation; Recombinant Proteins; Tumor Cells, Cultured | 1999 |
Distribution of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, fludarabine and cytarabine in mice: a whole-body autoradiography study.
Topics: Adenine Nucleotides; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Autoradiography; Brain; Cladribine; Clofarabine; Cytarabine; Lipid Metabolism; Mice; Mice, Inbred C57BL; Thymus Gland; Tissue Distribution; Tritium; Vidarabine | 1999 |
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Arabinonucleosides; B-Lymphocytes; Cell Survival; Cladribine; Clofarabine; Comet Assay; Deoxyadenosines; DNA Damage; DNA, Mitochondrial; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Potentials; Microinjections; Mitochondria; Time Factors; Tumor Cells, Cultured; Vidarabine | 2000 |
Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.
Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cell Line; Cladribine; Clofarabine; Cytogenetics; Deoxycytidine Kinase; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Leukemia; Phenotype; Phosphorylation; Ribonucleotide Reductases; Vidarabine | 2003 |
Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia.
Topics: Acute Disease; Adenine Nucleotides; Adult; Aged; Aged, 80 and over; Arabinonucleosides; Cell Survival; Cladribine; Clofarabine; Drug Evaluation; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Leukocytes, Mononuclear; Male; Middle Aged | 2003 |
A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Arabinonucleosides; Biological Transport; Cell Line; Cladribine; Clofarabine; Humans; Membrane Transport Proteins; Recombinant Proteins; Vidarabine; Xenopus laevis | 2006 |
Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma.
Topics: Adenine Nucleotides; Animals; Antifungal Agents; Arabinonucleosides; Chromatography, High Pressure Liquid; Cladribine; Clofarabine; Immunosuppressive Agents; Indicators and Reagents; Ketoconazole; Mass Spectrometry; Mice; Reference Standards; Reproducibility of Results | 2007 |
Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Antineoplastic Agents; Arabinonucleosides; Cladribine; Clofarabine; Deoxyadenine Nucleotides; Deoxyadenosines; Polyadenylation; Polynucleotide Adenylyltransferase; Substrate Specificity | 2008 |
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Animals; Antineoplastic Agents; Arabinonucleosides; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Breast Neoplasms; Cell Line; Cladribine; Clofarabine; Dogs; Drug Resistance, Neoplasm; Gene Expression Regulation; Humans; Mercaptopurine; Mice; Neoplasm Proteins; Nucleosides; RNA, Messenger; Transfection; Transport Vesicles | 2008 |
Bone marrow CFU-GM and human tumor xenograft efficacy of three antitumor nucleoside analogs.
Topics: Adenine Nucleotides; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Bone Marrow Cells; Cells, Cultured; Cladribine; Clofarabine; Granulocyte-Macrophage Progenitor Cells; HT29 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Models, Biological; Neoplasms; Treatment Outcome; Vidarabine Phosphate; Xenograft Model Antitumor Assays | 2009 |
Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Arabinonucleosides; Binding, Competitive; CHO Cells; Cladribine; Clofarabine; Cricetinae; Cricetulus; Cytotoxins; Humans; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptors, Purinergic P1; Vidarabine | 2012 |
Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.
Topics: Adenine Nucleotides; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Ataxia Telangiectasia Mutated Proteins; Busulfan; Cell Line, Tumor; Cladribine; Clofarabine; Epigenesis, Genetic; Humans; Leukemia, Myeloid, Acute; Membrane Potential, Mitochondrial; Real-Time Polymerase Chain Reaction; Vidarabine | 2015 |
The combination effects of bendamustine with antimetabolites against childhood acute lymphoblastic leukemia cells.
Topics: Adenine Nucleotides; Antimetabolites; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Bendamustine Hydrochloride; Cell Line, Tumor; Cell Proliferation; Child; Cladribine; Clofarabine; Cytarabine; Drug Administration Schedule; Drug Synergism; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vidarabine | 2016 |
Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cladribine; Clofarabine; Humans; Limit of Detection; Neoplasms; Polyphosphates; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Vidarabine | 2017 |
A Comparison of Clofarabine-based (GCLAC) and Cladribine-based (CLAG) Salvage Chemotherapy for Relapsed/Refractory AML.
Topics: Cladribine; Clofarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Retrospective Studies; Salvage Therapy | 2018 |
Multiply relapsed mixed histiocytosis in an adult responding to clofarabine after failure of cladribine.
Topics: Adenine Nucleotides; Adult; Arabinonucleosides; Cladribine; Clofarabine; Histiocytosis; Histiocytosis, Langerhans-Cell; Humans | 2020 |
In vivo kinetics of the genotoxic and cytotoxic activities of cladribine and clofarabine.
Topics: Animals; Antineoplastic Agents; Cladribine; Clofarabine; Kinetics; Male; Mice; Mice, Inbred ICR; Micronuclei, Chromosome-Defective; Micronucleus Tests; Reticulocytes | 2020 |
The global challenge of treating disseminated LCH.
Topics: Antineoplastic Agents; Child; Cladribine; Clofarabine; Cytarabine; Disease Management; Histiocytosis, Langerhans-Cell; Humans; Immunosuppressive Agents; Incidence; Pediatrics; Protein Kinase Inhibitors | 2020 |
Long-term results of low-intensity chemotherapy with clofarabine or cladribine combined with low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Clofarabine; Cytarabine; Decitabine; Humans; Leukemia, Myeloid, Acute; Middle Aged; Nucleophosmin; Treatment Outcome | 2021 |
Design, synthesis and biological evaluation of Nucleosidic CD99 inhibitors that selectively reduce Ewing sarcoma viability.
Topics: 12E7 Antigen; Cell Adhesion Molecules; Child; Cladribine; Clofarabine; DNA; Humans; Sarcoma, Ewing | 2023 |