clobazam and cannabidiol

clobazam has been researched along with cannabidiol in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (2.44)29.6817
2010's8 (19.51)24.3611
2020's32 (78.05)2.80

Authors

AuthorsStudies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bruno, PL; Geffrey, AL; Pollack, SF; Thiele, EA1
Bebin, EM; Cutter, GR; Gaston, TE; Liu, Y; Szaflarski, JP1
Carson, RP; Carter, EG; Doll, ED; Fu, C; Porcari, GS1
Appleton, R; Devinsky, O; Greenwood, S; Harden, CL; Morrison, G; Patel, AD; Sommerville, K; Thiele, EA; Wong, MH1
Blakey, G; Crockett, J; Morrison, G; Sommerville, K1
Ampah, SB; Bebin, EM; Cutter, GR; Gaston, TE; Grayson, LP; Liu, Y; Szaflarski, JP1
Abelev, SV; Absalom, NL; Anderson, LL; Arnold, JC; Chebib, M; Doohan, PT; Low, IK; Martin, LJ; McGregor, IS1
Bergmann, KR; Broekhuizen, K; Groeneveld, GJ1
Anagnos, CJ; Bruno, PL; Savage, TE; Skirvin, LA; Sourbron, J; Thiele, EA; Wolper, ES1
Mandelbaum, DE2
Brigo, F; Del Giovane, C; Lattanzi, S; Nardone, R; Silvestrini, M; Striano, P; Trinka, E; Zaccara, G1
Bialer, M; Perucca, E2
Checketts, D; Devinsky, O; Dunayevich, E; Knappertz, V; Morrison, G; Thiele, EA; Wright, S1
Crockett, J; Morrison, G; Taylor, L; VanLandingham, KE1
Brigo, F; Lattanzi, S; Trinka, E1
Cáceres-Guido, P; Maldonado, C; Riva, N; Schaiquevich, P; Vázquez, M1
Critchley, D; Gidal, B; Morrison, G; Patsalos, PN; Szaflarski, JP; VanLandingham, K1
Bhathal, H; Checketts, D; Chin, RFM; Dunayevich, E; Gunning, B; Mazurkiewicz-Bełdzińska, M; Nortvedt, C1
Czuczwar, SJ1
Dowd, Z; Gilmartin, CGS; Harijan, P; Parker, APJ1
Brigo, F; Eltze, C; Jones, K; Matricardi, S1
Carreño-Martínez, M; Gil Nagel-Rein, A; López-González, FJ; Villanueva, V1
Bruno, PL; Fleming, B; Grinspoon, R; Patel, S; Skirvin, LA; Thiele, EA; Wade, C; Wolper, E1
Balestrini, S; Hudgell, K; Nashef, L; Ritter, LM; Sidhu, MK; Silvennoinen, K; Sisodiya, SM1
García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V1
Główka, AK; Główka, FK; Karaźniewicz-Łada, M; Mikulska, AA1
Schubert-Bast, S; Strzelczyk, A2
Ameen, R; Bansal, D; Devi, N; Madaan, P; Sahu, JK1
Samanta, D1
Bonaventura, CD; Capovilla, G; Coppola, A; Elia, M; Ferlazzo, E; Gobbi, G; Marini, C; Meletti, S; Riva, A; Romeo, A; Santoro, K; Striano, P; Verrotti, A1
Battino, D; Bromley, R; Kochen, S; Meador, KJ; Pennell, PB; Thomas, SV; Tomson, T1
Aparasu, R; Estes, E; Reddy, DS; Talwar, A1
Bast, T; Becker, LL; Bertsche, A; Borggraefe, I; Boßelmann, CM; De Vries, H; Fahrbach, J; Hertzberg, C; Herz, NA; Hirsch, M; Holtkamp, M; Janello, C; Kaindl, AM; Klotz, KA; Kluger, GJ; Kühne, F; Kurlemann, G; Lerche, H; Makridis, KL; Prager, C; Pringsheim, M; Schubert-Bast, S; Schulz, J; Schulze-Bonhage, A; Steinbart, D; Steinhoff, BJ; Strzelczyk, A; Syrbe, S; von Podewils, F; Wagner, C; Wagner, J; Wilken, B1
Felton, E; Georgieva, D; Gidal, BE; Hartkopf, K; Hawk, L; Hsu, D; Langley, J; Margolis, A; Struck, A1
Arzimanoglou, A; Auvin, S; Berquin, P; Cross, JH; Desurkar, A; Fuller, D; Nabbout, R; Nortvedt, C; Pulitano, P; Rosati, A; Soto, V; Villanueva, V1
Bebin, EM; Cutter, GR; Gaston, TE; Grayson, L; Szaflarski, JP1

Reviews

15 review(s) available for clobazam and cannabidiol

ArticleYear
Cannabidiol efficacy and clobazam status: A systematic review and meta-analysis.
    Epilepsia, 2020, Volume: 61, Issue:6

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Treatment Outcome

2020
Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials.
    Epilepsia, 2020, Volume: 61, Issue:6

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Evidence-Based Medicine; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures

2020
Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials.
    Acta neurologica Scandinavica, 2020, Volume: 142, Issue:6

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures

2020
Clinical pharmacology of cannabidiol in refractory epilepsy.
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2020, 06-30, Volume: 44, Issue:5

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Resistant Epilepsy; Humans; Quality of Life

2020
Clinical implications of trials investigating drug-drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: Anticonvulsants; Cannabidiol; Clinical Trials as Topic; Clobazam; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Fatty Acids, Monounsaturated; Humans; Lennox Gastaut Syndrome; Valproic Acid

2020
Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
    Acta neurologica Scandinavica, 2021, Volume: 143, Issue:2

    Topics: Adult; Anticonvulsants; Cannabidiol; Clobazam; Epilepsies, Myoclonic; Female; Humans; Lennox Gastaut Syndrome; Male; Randomized Controlled Trials as Topic

2021
Interaction of cannabidiol with other antiseizure medications: A narrative review.
    Seizure, 2021, Volume: 86

    Topics: Animals; Anticonvulsants; Cannabidiol; Clobazam; Drug Interactions; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic

2021
Anti-seizure medications for Lennox-Gastaut syndrome.
    The Cochrane database of systematic reviews, 2021, 04-07, Volume: 4

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Cinnamates; Clobazam; Electroencephalography; Felbamate; Humans; Lamotrigine; Lennox Gastaut Syndrome; Middle Aged; Placebos; Randomized Controlled Trials as Topic; Topiramate; Triazoles; Wakefulness; Young Adult

2021
New therapeutic approach in Dravet syndrome and Lennox-Gastaut syndrome with cannabidiol.
    Revista de neurologia, 2021, Apr-30, Volume: 72, Issue:S01

    Topics: Administration, Oral; Adolescent; Algorithms; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Clobazam; Compassionate Use Trials; Double-Blind Method; Drug Resistant Epilepsy; Drug Synergism; Epilepsies, Myoclonic; Humans; Infant; Lennox Gastaut Syndrome; Treatment Outcome

2021
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
    Revista de neurologia, 2021, 09-10, Volume: 73, Issue:S01

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Phenobarbital; Practice Guidelines as Topic; Pyrrolidinones; Spain; Triazoles; Valproic Acid

2021
Pharmacokinetic Drug-Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients.
    International journal of molecular sciences, 2021, Sep-03, Volume: 22, Issue:17

    Topics: Anticonvulsants; Cannabidiol; Carbamazepine; Clobazam; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Epilepsy; Humans; Nutrients; SARS-CoV-2

2021
Short-term and long-term efficacy and safety of antiseizure medications in Lennox Gastaut syndrome: A network meta-analysis.
    Seizure, 2022, Volume: 99

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Humans; Lennox Gastaut Syndrome; Network Meta-Analysis; Randomized Controlled Trials as Topic; Seizures; Treatment Outcome

2022
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
    Epileptic disorders : international epilepsy journal with videotape, 2022, 12-01, Volume: 24, Issue:6

    Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Everolimus; Felbamate; Female; Fenfluramine; Gabapentin; Humans; Infant; Lacosamide; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenobarbital; Phenytoin; Prospective Studies; Tiagabine; Topiramate; Valproic Acid; Vigabatrin; Zonisamide

2022
Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies.
    CNS drugs, 2022, Volume: 36, Issue:10

    Topics: Autism Spectrum Disorder; Bromides; Cannabidiol; Clobazam; Cognition; Ethosuximide; Everolimus; Felbamate; Fenfluramine; Humans; Lacosamide; Lamotrigine; Levetiracetam; Pregabalin; Spasms, Infantile; Sulfides; Topiramate; Valproic Acid; Vigabatrin; Zinc Compounds; Zonisamide

2022
Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis.
    Experimental neurology, 2023, Volume: 359

    Topics: Adult; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug Resistant Epilepsy; Epilepsies, Myoclonic; Epilepsy; Humans; Lennox Gastaut Syndrome; Seizures; Treatment Outcome

2023

Trials

5 trial(s) available for clobazam and cannabidiol

ArticleYear
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.
    Neurology, 2018, 04-03, Volume: 90, Issue:14

    Topics: Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Myoclonic; Follow-Up Studies; Humans; Treatment Outcome

2018
A Phase 1, Open-Label, Pharmacokinetic Trial to Investigate Possible Drug-Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects.
    Clinical pharmacology in drug development, 2019, Volume: 8, Issue:8

    Topics: Adult; Anticonvulsants; Cannabidiol; Clobazam; Cytochrome P-450 CYP2C19; Dioxolanes; Drug Interactions; Female; Genotype; Healthy Volunteers; Humans; Male; Valproic Acid

2019
Drug-drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug Interactions; Drug Resistant Epilepsy; Female; Humans; Male; Treatment Outcome; Young Adult

2019
A Phase 2, Double-Blind, Placebo-Controlled Trial to Investigate Potential Drug-Drug Interactions Between Cannabidiol and Clobazam.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:10

    Topics: Adult; Anticonvulsants; Cannabidiol; Clobazam; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged

2020
Real-world, long-term evaluation of the tolerability and therapy retention of Epidiolex® (cannabidiol) in patients with refractory epilepsy.
    Epilepsy & behavior : E&B, 2023, Volume: 141

    Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Drug Resistant Epilepsy; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Young Adult

2023

Other Studies

21 other study(ies) available for clobazam and cannabidiol

ArticleYear
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship

2003
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.
    Epilepsia, 2015, Volume: 56, Issue:8

    Topics: Adolescent; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; Female; Humans; Male; Young Adult

2015
Interactions between cannabidiol and commonly used antiepileptic drugs.
    Epilepsia, 2017, Volume: 58, Issue:9

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Topiramate; Triazoles; Young Adult

2017
Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Adolescent; Anticonvulsants; Attention; Cannabidiol; Cannabis; Child; Child, Preschool; Clobazam; Drug Resistant Epilepsy; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Female; Hospitals; Humans; Longitudinal Studies; Male; Retrospective Studies; Seizures; Treatment Outcome; United States; United States Food and Drug Administration

2018
Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.
    Epilepsia, 2019, Volume: 60, Issue:11

    Topics: Animals; Anticonvulsants; Cannabidiol; Clobazam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Mice; Mice, Transgenic; NAV1.1 Voltage-Gated Sodium Channel

2019
Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency.
    British journal of clinical pharmacology, 2020, Volume: 86, Issue:2

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Humans; Lennox Gastaut Syndrome; Seizures

2020
Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam.
    Epilepsy research, 2020, Volume: 160

    Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Seizures; Treatment Outcome; Young Adult

2020
Re: Efficacy of Cannabidiol in Subjects with Refractory Epilepsy Relative to Concomitant Use of Clobazam.
    Epilepsy research, 2022, Volume: 180

    Topics: Anticonvulsants; Benzodiazepines; Cannabidiol; Clobazam; Drug Resistant Epilepsy; Humans; Seizures

2022
Response: Cannabidiol antiseizure activity and its interactions with clobazam: "It's déjà vu all over again" Yogi Berra.
    Epilepsia, 2020, Volume: 61, Issue:8

    Topics: Cannabidiol; Clobazam; Randomized Controlled Trials as Topic

2020
Cannabidiol antiseizure activity and its interactions with clobazam: "It's déjà vu all over again" Yogi Berra.
    Epilepsia, 2020, Volume: 61, Issue:8

    Topics: Cannabidiol; Clobazam; Randomized Controlled Trials as Topic

2020
Cannabidiol efficacy and clobazam coadministration: Where do we stand now?
    Epilepsia, 2020, Volume: 61, Issue:8

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Drug Resistant Epilepsy; Humans

2020
Commentary on: Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.
    Epilepsia, 2020, Volume: 61, Issue:10

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Humans; Lennox Gastaut Syndrome

2020
The long-term efficacy of cannabidiol in the treatment of refractory epilepsy.
    Epilepsia, 2021, Volume: 62, Issue:7

    Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Male; Retrospective Studies; Seizures; Treatment Outcome; Tuberous Sclerosis; Young Adult

2021
Two-center experience of cannabidiol use in adults with Dravet syndrome.
    Seizure, 2021, Volume: 91

    Topics: Adult; Anticonvulsants; Cannabidiol; Clobazam; Epilepsies, Myoclonic; Female; Humans; Middle Aged; Quality of Life; Young Adult

2021
A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication.
    CNS drugs, 2022, Volume: 36, Issue:3

    Topics: Adult; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug Therapy, Combination; Epilepsies, Myoclonic; Epileptic Syndromes; Fenfluramine; Humans; Sleepiness; Spasms, Infantile; Topiramate

2022
Pharmacotherapeutic management of seizures in patients with Angleman Syndrome.
    Expert opinion on pharmacotherapy, 2022, Volume: 23, Issue:13

    Topics: Anticonvulsants; Cannabidiol; Child; Clobazam; Clonazepam; Ethosuximide; Humans; Lamotrigine; Levetiracetam; Quality of Life; Seizures; Topiramate; Valproic Acid

2022
An Italian consensus on the management of Lennox-Gastaut syndrome.
    Seizure, 2022, Volume: 101

    Topics: Anticonvulsants; Cannabidiol; Clobazam; Consensus; Fenfluramine; Humans; Lamotrigine; Lennox Gastaut Syndrome; Quality of Life; Topiramate; Valproic Acid

2022
Real-world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Middle Aged; Retrospective Studies; Seizures; Young Adult

2023
Retrospective chart review study of use of cannabidiol (CBD) independent of concomitant clobazam use in patients with Lennox-Gastaut syndrome or Dravet syndrome.
    Seizure, 2023, Volume: 110

    Topics: Adolescent; Anticonvulsants; Cannabidiol; Clobazam; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Retrospective Studies; Seizures; Treatment Outcome

2023
Final analysis of potential drug-drug interactions between highly purified cannabidiol and anti-seizure medications in an open-label expanded access program.
    Epilepsia open, 2023, Volume: 8, Issue:4

    Topics: Adult; Anticonvulsants; Cannabidiol; Child; Clobazam; Drug Interactions; Humans; Topiramate

2023