clivorine and retrorsine

clivorine has been researched along with retrorsine* in 2 studies

Other Studies

2 other study(ies) available for clivorine and retrorsine

Article	Year
Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids. Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2020, Volume: 38, Issue:2 Topics: Activation, Metabolic; Animals; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver; Lung; Monocrotaline; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats	2020
Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2 The formation of the pyrrolic alcohol glutathione (GSH) conjugates of two different types of pyrrolizidine alkaloids (PAs), i.e. clivorine (an otonecine-type PA) and retrorsine (a retronecine-type PA), was investigated with rat microsomes in the presence of GSH. Two GSH conjugates identified as metabolites of retrorsine were the pyrrolic alcohol conjugated with one [7-GSH-dehydroretronecine (DHP)] or two (7,9-diGSH-DHP) molecules of GSH. diGSH-DHP, the less abundant of the two conjugates, had not been previously identified as a metabolite of PAs. In the case of clivorine, 7-GSH-DHP was identified. This is the first unequivocal identification of a pyrrolic metabolite of an otonecine-type PA. Consequently, this study provides the strongest evidence obtained to date to support the hypothesis, suggested >25 years ago, that the mechanism of hepatotoxicity induced by otonecine-type PAs involves key metabolic steps similar to those for retronecine-type PAs. Topics: Alcohols; Animals; Chromatography, High Pressure Liquid; Glutathione; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley	1998

Article

Year

Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids.

Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2020, Volume: 38, Issue:2

Topics: Activation, Metabolic; Animals; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver; Lung; Monocrotaline; Proteins; Pyrroles; Pyrrolizidine Alkaloids; Rats

2020

Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid.

Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2

The formation of the pyrrolic alcohol glutathione (GSH) conjugates of two different types of pyrrolizidine alkaloids (PAs), i.e. clivorine (an otonecine-type PA) and retrorsine (a retronecine-type PA), was investigated with rat microsomes in the presence of GSH. Two GSH conjugates identified as metabolites of retrorsine were the pyrrolic alcohol conjugated with one [7-GSH-dehydroretronecine (DHP)] or two (7,9-diGSH-DHP) molecules of GSH. diGSH-DHP, the less abundant of the two conjugates, had not been previously identified as a metabolite of PAs. In the case of clivorine, 7-GSH-DHP was identified. This is the first unequivocal identification of a pyrrolic metabolite of an otonecine-type PA. Consequently, this study provides the strongest evidence obtained to date to support the hypothesis, suggested >25 years ago, that the mechanism of hepatotoxicity induced by otonecine-type PAs involves key metabolic steps similar to those for retronecine-type PAs.

Topics: Alcohols; Animals; Chromatography, High Pressure Liquid; Glutathione; Male; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley

1998