clioquinol and amyloid beta-peptides

clioquinol has been researched along with amyloid beta-peptides in 10 studies

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (50.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ames, D; Beyreuther, K; Bush, AI; Carrington, D; Cherny, R; Davis, S; Kiers, L; Li, QX; Macfarlane, S; MacGregor, L; Mackinnon, A; Masters, CL; Mastwyk, M; Mavros, C; Ritchie, CW; Tammer, A; Tanzi, RE; Volitakis, I; Xilinas, M	1
Ban, T; Goto, Y; Kawai, T; Naiki, H; Raman, B; Sakai, M; Yamaguchi, K	1
Barnham, KJ; Bush, AI; Cherny, RA; Du, T; Evin, G; Hill, AF; Hoke, DE; Holsinger, RM; Laughton, KM; Li, QX; Masters, CL; Sharples, RA; Volitakis, I; White, AR; Xilinas, ME	1
D'Costa, K; Harvey, AR; Hill, F; Laws, SM; Levy, E; Martins, IJ; Martins, RN; Munns, S; Shaw, JE; Taddei, K; Verdile, G	1
Adlard, PA; Barnham, KJ; Bush, AI; Cappai, R; Charman, SA; Cherny, RA; Cortes, M; Deleva, K; Finkelstein, DI; Gautier, E; Kok, G; Laughton, K; Li, QX; Liu, X; Lynch, T; Masters, CL; Nicolazzo, JA; Perez, K; Ritchie, CW; Robb, E; Smith, JP; Tanzi, RE; Volitakis, I; Wilkins, S	1
Barnham, KJ; Blake, RE; Caragounis, A; Cherny, RA; Crouch, PJ; Du, T; Filiz, G; Laughton, K; Li, QX; Masters, CL; Nguyen, DN; Perez, KA; Soon, CP; Tew, DJ; Trounce, IA; White, AR	1
Bedo, J; Blennow, K; Bush, AI; Cummings, JL; Faux, NG; Gunn, A; Harrison, J; Herd, CM; Ingelsson, M; Lannfelt, L; Masters, CL; Rembach, A; Ritchie, CW; Tanzi, RE; Tsatsanis, A; Zetterberg, H	1
Han, Y; He, C; Huang, X; Wang, Y; Zhu, L	1
Emadi, S; Tahmasebinia, F	1
Wang, C; Wang, K; Wang, Z	1

Trials

2 trial(s) available for clioquinol and amyloid beta-peptides

Article	Year
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Archives of neurology, 2003, Volume: 60, Issue:12 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Chelating Agents; Clioquinol; Cognition; Copper; Double-Blind Method; Female; Humans; Male; Middle Aged; Peptide Fragments; Pilot Projects; Severity of Illness Index; Zinc	2003
PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. Journal of Alzheimer's disease : JAD, 2010, Volume: 20, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Area Under Curve; Australia; Clioquinol; Cognition Disorders; Copper; Dose-Response Relationship, Drug; Double-Blind Method; Executive Function; Humans; International Cooperation; Ionophores; Neuropsychological Tests; Peptide Fragments; ROC Curve; Superoxide Dismutase; Superoxide Dismutase-1; Sweden; tau Proteins	2010

Article

Year

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

Archives of neurology, 2003, Volume: 60, Issue:12

Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Chelating Agents; Clioquinol; Cognition; Copper; Double-Blind Method; Female; Humans; Male; Middle Aged; Peptide Fragments; Pilot Projects; Severity of Illness Index; Zinc

2003

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses.

Journal of Alzheimer's disease : JAD, 2010, Volume: 20, Issue:2

Topics: Alzheimer Disease; Amyloid beta-Peptides; Area Under Curve; Australia; Clioquinol; Cognition Disorders; Copper; Dose-Response Relationship, Drug; Double-Blind Method; Executive Function; Humans; International Cooperation; Ionophores; Neuropsychological Tests; Peptide Fragments; ROC Curve; Superoxide Dismutase; Superoxide Dismutase-1; Sweden; tau Proteins

2010

Other Studies

8 other study(ies) available for clioquinol and amyloid beta-peptides

Article	Year
Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide. The Journal of biological chemistry, 2005, Apr-22, Volume: 280, Issue:16 Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Infective Agents, Local; Circular Dichroism; Clioquinol; Copper; Humans; Iron; Metals, Heavy; Peptide Fragments; Spectrophotometry, Ultraviolet; Time Factors; Zinc	2005
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. The Journal of biological chemistry, 2006, Jun-30, Volume: 281, Issue:26 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Infective Agents, Local; Cell Line, Tumor; CHO Cells; Clioquinol; Copper; Cricetinae; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Iron; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Mice; Neuroblastoma; Peptide Fragments; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Transfection; Up-Regulation; Zinc	2006
Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of aging, 2010, Volume: 31, Issue:2 Topics: Amyloid beta-Peptides; Animals; Bacteriophages; Cell Line, Tumor; Cell Survival; Clioquinol; Escherichia coli; Genetic Techniques; Humans; Hydro-Lyases; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Peptide Fragments; Peptide Library; Peptides; Protein Binding; Rats; Sequence Analysis, DNA; Superoxide Dismutase	2010
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron, 2008, Jul-10, Volume: 59, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Animal; Cell Line, Tumor; Clioquinol; Cognition; Copper; Disease Models, Animal; Hippocampus; Humans; Hydroxyquinolines; In Vitro Techniques; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroblastoma; Peptide Fragments; Presenilin-1; Zinc	2008
Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation. Journal of neurochemistry, 2009, Volume: 108, Issue:5 Topics: Amyloid; Amyloid beta-Peptides; Clioquinol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Glutamine; Humans; Insulysin; Matrix Metalloproteinase 2; Microscopy, Electron, Transmission; Mutation; Neprilysin; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Zinc	2009
Disaggregation ability of different chelating molecules on copper ion-triggered amyloid fibers. The journal of physical chemistry. B, 2014, Aug-07, Volume: 118, Issue:31 Topics: Amyloid; Amyloid beta-Peptides; Calorimetry; Chelating Agents; Clioquinol; Copper; Ions; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Structure; Peptide Fragments; Thermodynamics	2014
Effect of metal chelators on the aggregation of beta-amyloid peptides in the presence of copper and iron. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2017, Volume: 30, Issue:2 Topics: Amyloid beta-Peptides; Cations; Chelating Agents; Clioquinol; Copper; Edetic Acid; Humans; Iron; Microscopy, Atomic Force; Peptide Fragments; Protein Aggregates; Solutions	2017
Development of gold nanoparticle based colorimetric method for quantitatively studying the inhibitors of Cu(2+)/Zn(2+) induced β-amyloid peptide assembly. Analytica chimica acta, 2015, Feb-09, Volume: 858 Topics: Affinity Labels; Amyloid beta-Peptides; Biotin; Chlorides; Circular Dichroism; Clioquinol; Colorimetry; Copper Sulfate; Edetic Acid; Egtazic Acid; Gold; Histidine; Inhibitory Concentration 50; Metal Nanoparticles; Microscopy, Electron, Transmission; Peptide Fragments; Protein Aggregates; Streptavidin; Zinc Compounds	2015