clephedrone and 4-fluoromethcathinone

clephedrone has been researched along with 4-fluoromethcathinone* in 2 studies

Other Studies

2 other study(ies) available for clephedrone and 4-fluoromethcathinone

Article	Year
International journal of molecular sciences, 2020, Apr-18, Volume: 21, Issue:8 Halogenation of amphetamines and methcathinones has become a common method to obtain novel psychoactive substances (NPS) also called "legal highs". The Topics: Adenosine Triphosphate; Amphetamine; Amphetamines; Apoptosis; Cell Differentiation; Cell Line, Tumor; Electron Transport; Halogenation; Humans; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Methylamines; Mitochondria; Neuroblastoma; Oxygen Consumption; Propiophenones; Reactive Oxygen Species; Superoxides	2020
Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences, 2017, Volume: 32 Many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (DAT, NET, SERT, respectively). Drug selectivity at DAT vs. SERT is a key determinant of abuse potential for monoamine transporter substrates and inhibitors, such that potency at DAT > SERT is associated with high abuse potential, whereas potency at DAT < SERT is associated with low abuse potential. Quantitative structure-activity relationship (QSAR) studies with a series of 4-substituted methcathinone analogs identified volume of the 4-position substituent on the methcathinone phenyl ring as one structural determinant of both DAT vs. SERT selectivity and abuse-related behavioral effects in an intracranial self-stimulation procedure in rats. Subsequent modeling studies implicated specific amino acids in DAT and SERT that might interact with 4-substituent volume to determine effects produced by this series of cathinone analogs. These studies illustrate use of QSAR analysis to investigate pharmacology of cathinones and function of monoamine transporters. Topics: Amphetamine; Animals; Behavior, Animal; Dopamine Plasma Membrane Transport Proteins; Fenfluramine; Humans; Methamphetamine; Methylamines; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine Plasma Membrane Transport Proteins; Propiophenones; Psychotropic Drugs; Quantitative Structure-Activity Relationship; Rats; Self Administration; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Substance-Related Disorders	2017

Article

Year

International journal of molecular sciences, 2020, Apr-18, Volume: 21, Issue:8

Halogenation of amphetamines and methcathinones has become a common method to obtain novel psychoactive substances (NPS) also called "legal highs". The

Topics: Adenosine Triphosphate; Amphetamine; Amphetamines; Apoptosis; Cell Differentiation; Cell Line, Tumor; Electron Transport; Halogenation; Humans; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Methylamines; Mitochondria; Neuroblastoma; Oxygen Consumption; Propiophenones; Reactive Oxygen Species; Superoxides

2020

Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs.

Current topics in behavioral neurosciences, 2017, Volume: 32

Many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (DAT, NET, SERT, respectively). Drug selectivity at DAT vs. SERT is a key determinant of abuse potential for monoamine transporter substrates and inhibitors, such that potency at DAT > SERT is associated with high abuse potential, whereas potency at DAT < SERT is associated with low abuse potential. Quantitative structure-activity relationship (QSAR) studies with a series of 4-substituted methcathinone analogs identified volume of the 4-position substituent on the methcathinone phenyl ring as one structural determinant of both DAT vs. SERT selectivity and abuse-related behavioral effects in an intracranial self-stimulation procedure in rats. Subsequent modeling studies implicated specific amino acids in DAT and SERT that might interact with 4-substituent volume to determine effects produced by this series of cathinone analogs. These studies illustrate use of QSAR analysis to investigate pharmacology of cathinones and function of monoamine transporters.

Topics: Amphetamine; Animals; Behavior, Animal; Dopamine Plasma Membrane Transport Proteins; Fenfluramine; Humans; Methamphetamine; Methylamines; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine Plasma Membrane Transport Proteins; Propiophenones; Psychotropic Drugs; Quantitative Structure-Activity Relationship; Rats; Self Administration; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Substance-Related Disorders

2017