clay has been researched along with carboxyl-radical* in 1 studies
1 other study(ies) available for clay and carboxyl-radical
| Article | Year |
|---|---|
The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response.
We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations. Topics: Aluminum Silicates; Animals; Antigens; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Bacterial Vaccines; Carbon Dioxide; Clay; Cricetinae; Feasibility Studies; Immunity, Humoral; Immunoglobulin G; Leptospira interrogans; Lipoproteins; Mesocricetus; Nanotubes, Carbon; Recombinant Proteins | 2015 |