clavulanic acid has been researched along with cephamycin c in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 12 (63.16) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hodgson, JE; Ward, JM | 1 |
| Braña, AF; Sánchez, L | 1 |
| Bezbaruah, RL; Dutta, NN; Roy, MK; Thakur, R | 1 |
| Jensen, SE; Paradkar, AS; Thai, W | 1 |
| Anders, C; Barton, B; Greaves, P; Griffin, A; Griffin, J; Hughes, C; Jensen, SE; Mosher, RH; Paradkar, AS | 1 |
| Alexander, DC; Jensen, SE; Leskiw, BK; Trepanier, NK | 1 |
| Liras, P; Martín, JF; Pérez-Redondo, R; Rodríguez-García, A; Santamarta, I | 1 |
| Jin, W; Kang, SG; Kim, SK; Lee, KJ; Lee, SH; Ochi, K; Ryu, YG; Saito, N | 1 |
| Alexander, DC; Jensen, SE; Kaziuk, TL; Tahlan, K; Wang, L | 1 |
| Bignell, DR; Colvin, KR; Jensen, SE; Leskiw, BK; Tahlan, K | 1 |
| Liras, P; Lorenzana, LM; Martín, JF; Pérez-Redondo, R; Santamarta, I | 1 |
| Gomez-Escribano, JP; Liras, P; Martín, JF; Pisabarro, A | 1 |
| Koekman, B; Liras, P; López-García, MT; Martín, JF; Pérez-Redondo, R; Santamarta, I | 1 |
| Bibb, MJ; Gomez-Escribano, JP; Hesketh, A; Liras, P; Martín, JF | 1 |
| Jensen, SE; Kim, DW; Kim, ES; Lee, KJ; Song, JY | 1 |
| Liras, P; Lorenzana, LM; Martín, JF; Nárdiz, N; Santamarta, I | 1 |
| Álvarez-Álvarez, R; Kurt, A; Liras, P; Özcengiz, G | 1 |
| Alvarez-Álvarez, R; Liras, P; Martínez-Burgo, Y; Pérez-Redondo, R; Prieto-Domínguez, A; Rodríguez-García, A; Santamarta, I | 1 |
| Araujo, ML; Baptista, AS; Cavallieri, AP; Leite, CA | 1 |
19 other study(ies) available for clavulanic acid and cephamycin c
| Article | Year |
|---|---|
The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces.
Topics: Bacterial Proteins; Cephamycins; Chromosome Mapping; Chromosomes, Bacterial; Clavulanic Acid; Clavulanic Acids; Cloning, Molecular; Cosmids; DNA, Bacterial; Genes, Bacterial; Genetic Vectors; Intramolecular Transferases; Isomerases; Mixed Function Oxygenases; Multigene Family; Penicillin-Binding Proteins; Species Specificity; Streptomyces | 1993 |
Cell density influences antibiotic biosynthesis in Streptomyces clavuligerus.
Topics: Amino Acids; Bacteria; Biological Factors; Cephamycins; Clavulanic Acid; Clavulanic Acids; Culture Media; Culture Media, Conditioned; Hot Temperature; Kinetics; Peptides; Spores, Bacterial; Streptomyces | 1996 |
Coordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus.
Topics: Anti-Bacterial Agents; Cephamycins; Clavulanic Acid; Culture Media; Streptomyces | 1999 |
Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; beta-Lactamase Inhibitors; Blotting, Southern; Blotting, Western; Cephamycins; Clavulanic Acid; Enzyme Inhibitors; Molecular Sequence Data; Mutation; Penicillin G; Sequence Analysis, DNA; Streptomyces | 2001 |
Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.
Topics: Cephamycins; Clavulanic Acid; Gene Deletion; Genes, Bacterial; Genetic Engineering; Lysine; Streptomyces; Transaminases | 2001 |
The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.
Topics: Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Codon; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Mutation; Protein Biosynthesis; RNA, Bacterial; RNA, Transfer, Leu; Sequence Analysis, DNA; Streptomyces | 2002 |
CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.
Topics: Amino Acid Isomerases; Bacterial Proteins; Cephamycins; Clavulanic Acid; DNA-Binding Proteins; Genes, Bacterial; Genes, Regulator; Promoter Regions, Genetic; Recombinant Fusion Proteins; Streptomyces; Transcription Factors | 2002 |
Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus.
Topics: Bacterial Proteins; Cephamycins; Clavulanic Acid; Culture Media; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Guanosine Pentaphosphate; Guanosine Tetraphosphate; Ligases; Molecular Sequence Data; Mutation; Phylogeny; Sequence Analysis, DNA; Streptomyces | 2004 |
Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus.
Topics: Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Escherichia coli; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Mutation; Protein Biosynthesis; Streptomyces; Transcription Factors; Transcription, Genetic | 2004 |
Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Open Reading Frames; Repressor Proteins; Sequence Analysis, DNA; Sigma Factor; Streptomyces | 2005 |
Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Cephamycins; Clavulanic Acid; Cloning, Molecular; DNA-Binding Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Order; Genes, Regulator; Molecular Sequence Data; Mutation; Receptors, GABA-A; Recombinant Proteins; Response Elements; Streptomyces; Transcription Factors | 2005 |
An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.
Topics: Amino Acids; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Cephamycins; Clavulanic Acid; Deoxyribonucleases, Type II Site-Specific; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Genes, Regulator; Molecular Sequence Data; Mutation; Nucleotides; Open Reading Frames; Ribosomal Proteins; Streptomyces; Thiostrepton; Transcription Factors; Transcription, Genetic | 2006 |
Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.
Topics: Acetates; Amino Acid Sequence; Bacterial Proteins; Blotting, Southern; Cephamycins; Clavulanic Acid; Fatty Acids; Gene Deletion; Gene Expression Regulation, Bacterial; Leucine; Molecular Sequence Data; Mutation; Operon; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Streptomyces; Transcription, Genetic | 2007 |
Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.
Topics: Base Sequence; Cephamycins; Clavulanic Acid; Cloning, Molecular; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Guanosine Pentaphosphate; Ligases; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; Sequence Analysis, DNA; Spores, Bacterial; Streptomyces; Transcription Initiation Site; Transcriptional Activation | 2008 |
A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biotechnology; Cephamycins; Clavulanic Acid; Culture Media; Gene Expression Regulation, Bacterial; Multigene Family; Mutation; Open Reading Frames; Streptomyces | 2009 |
A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.
Topics: Bacterial Proteins; Cephamycins; Clavulanic Acid; Gene Expression Regulation, Bacterial; Lactams; Membrane Transport Proteins; Mutation; Streptomyces; Thiosulfate Sulfurtransferase | 2011 |
Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus.
Topics: Biosynthetic Pathways; Cephamycins; Clavulanic Acid; DNA, Intergenic; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Real-Time Polymerase Chain Reaction; Sequence Deletion; Streptomyces; Transcription Factors | 2013 |
Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.
Topics: Biosynthetic Pathways; Cephamycins; Clavulanic Acid; Culture Media; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Reporter; Luciferases; Multigene Family; Real-Time Polymerase Chain Reaction; Streptomyces; Transcription Factors | 2014 |
Dissociation of cephamycin C and clavulanic acid biosynthesis by 1,3-diaminopropane in Streptomyces clavuligerus.
Topics: Biosynthetic Pathways; Cephamycins; Clavulanic Acid; Culture Media; Diamines; Streptomyces | 2016 |