Page last updated: 2024-08-23

clavulanic acid and beta-lactams

clavulanic acid has been researched along with beta-lactams in 102 studies

Research

Studies (102)

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (42.16)	18.7374
1990's	11 (10.78)	18.2507
2000's	23 (22.55)	29.6817
2010's	21 (20.59)	24.3611
2020's	4 (3.92)	2.80

Authors

Authors	Studies
Acar, JF; Goldstein, FW; Kitzis, MD	1
Labia, R; Lenfant, F; Masson, JM	1
Neu, HC	1
Elson, S; Southgate, R	1
Ball, AP; Brookes, GR; Davey, PG; Farrell, ID; Geddes, AM	1
Cole, M	1
Belasco, JG; Charnas, RL; Fisher, J; Khosla, S; Knowles, JR	1
D'Costa, LJ; Fast, MV; Karasira, P; Maclean, IW; Nsanze, H; Plummer, FA; Ronald, AR	1
Andrews, JM; Bedford, KA; Wise, R	1
Fu, KP; Neu, HC	2
Andrews, JM; Patel, N; Wise, R	1
Crast, LB; Gottstein, WJ; Graham, RG; Haynes, UJ; McGregor, DN	1
Frère, JM; Ghuysen, JM; Kelly, JA; Klein, D	1
Li, JT; Moosdeen, F; Williams, JD	1
Baumgärtner, M; Wundt, W	1
Bidwell, JL; Bywater, MJ; Holt, HA; Reeves, DS	1
Rogers, DT; Russell, AD	1
Van Klingeren, B; Van Wijngaarden, LJ	1
Ansink-Schipper, MC; Coster, JF; Coutinho, RA; De Koning, GA; Tio, D	1
Feng, M; Li, JT; Ma, LJ; Tao, WY; Wang, S	1
O'Grady, FW	1
Piot, P; Van Dyck, E	1
Hashimoto, T; Matsuura, M; Mitsuhashi, S; Nakazawa, H	1
Coleman, K; Fisher, J; Hunter, PA; Taylor, D	1
Pohlod, DJ; Quinn, EL; Saravolatz, LD; Somerville, MM	1
Cole, P; Roberts, DE	1
Ivanitskaia, LP; Nikishina, VG	1
Albritton, WL; Girouard, YC; Maclean, IW; Ronald, AR	1
Mantoku, A; Ogawara, H	1
Duez, C; Frère, JM; Ghuysen, JM; Kelly, JA	1
Kusmiesz, H; Nelson, JD; Shelton, S	1
Rolinson, GN	1
De Klerk, HC; Forder, AA; Gricius, ME; Hallett, AF; Koornhof, HJ; Lindeque, KP; Neiteler, BF; Robinson, R; Van den Ende, J; Van Rensburg, AJ; Venter, L	1
Celliers, D; Du Plessis, DJ; Lindeque, KP; Van Rensburg, AJ	1
Hatzimichelakis, N; Kontomichalou, P; Makris, G; Paniara-Volika, O; Paraskevopoulou, E; Saroglou, G; Sima, A; Vassilopoulos, N	1
Farmer, T; Reading, C	2
Lismont, MJ; Van der Linden, MP; Yourassowsky, E	1
Aoki, H; Okuhara, M	1
Charnas, RL; Knowles, JR	1
Ulmer, WT; Zimmermann, I	1
Avery, GS; Brogden, RN; Carmine, A; Heel, RC; Morley, PA; Speight, TM	1
Gaspar, MC; Soriano, F	1
Amicosante, G; Fattorini, L; Franceschini, N; Frère, JM; Galleni, M; Oratore, A; Orefici, G; Quinting, B	1
Frère, JM; Ghuysen, MF; Matagne, A	1
Inoue, E; Mitsuhashi, S; Muratani, T; Nakane, T; Yokota, E	1
Alarcón, MA; Campos, M; González, H; Sánchez, R	1
Jin, YF; Piddock, LJ; Turner, HL	1
Gaviraghi, G; Perboni, A; Salvatori, A; Spadoni, G; Tamburini, B; Tarzia, G; Xerri, L	1
Angehrn, P; Hubschwerlen, C; Kania, M; Page, MG; Richter, HG; Specklin, JL; Winkler, FK	1
Balko, T; Hoban, DJ; Karlowsky, JA; Palatnick, LP; Zhanel, GG	1
Giakkoupi, P; Legakis, NJ; Tzelepi, E; Tzouvelekis, LS	1
Degnan, BA; Farmer, TH; Payne, DJ	1
Foustoukou, M; Lebessi, E; Legakis, NJ; Stamos, G; Tzouvelekis, LS; Vourli, S	1
Jamieson, CE; Lambert, PA; Simpson, IN	1
Anderson, VE; Bethel, CR; Bonomo, RA; Helfand, MS; Hujer, AM; Hujer, KM	1
Fosse, T; Giraud-Morin, C; Madinier, I	1
Li, C; Lister, PD; Nicolau, DP; Nightingale, CH; Quintiliani, R	1
Bertrand, X; Lallemand-De-Conto, S; Talon, D; Thouverez, M	1
Aguado-García, JM; Lumbreras-Bermejo, C; Martín-Herrero, JE	1
Dinçer, I; Ergin, A; Kocagöz, T	1
Higgins, PG; Seifert, H; Stefanik, D; Wisplinghoff, H	1
Antonini, M; Carli, S; Moroni, P; Pisoni, G; Ruffo, G; Vellere, F	1
Behra-Miellet, J; Calvet, L; Dubreuil, L	1
Brooks, BM; Coleman, JW; Hart, CA	1
Egawa, S; Endo, K; Hosobe, T; Kiyota, H; Kobayashi, I; Onodera, S; Suzuki, H; Takahashi, T	1
Broide, E; Raveh, D; Rudensky, B; Yinnon, AM	1
Cattoir, V; Corvec, S; Drugeon, H; Faccone, D; Galas, M; Mugnier, P; Nordmann, P; Pasteran, F; Petroni, A; Poirel, L; Rapoport, M	1
Bedenic, B; Kalenic, S; Mihaljevic, Lj; Plecko, V; Sviben, M; Tonkic, M; Vranes, J	1
Bonomo, RA; Buynak, JD; Carey, PR; Helfand, MS; Taracila, MA; Totir, MA; van den Akker, F	1
Bonnet, R; Brebion, A; Constantin, JM; Delmas, J; Dubois, D; Robin, F	1
Anuradha, K; Lakshmi, V; Sailaja, VV; Satheesh, T; Umabala, P	1
Ballerini, V; Cera, G; Limansky, AS; Marchiaro, P; Morán-Barrio, J; Mussi, MA; Spalding, T; Viale, AM; Vila, AJ	1
Hsiao, YJ; Hu, RM; Huang, SC; Lin, CW; Yang, TC	1
Cantón, R; Giske, CG; Kahlmeter, G; Nordmann, P; Paterson, DL; Sundsfjord, AS; Walsh, TR; Woodford, N	1
Aguilar, L; Alou, L; Cafini, F; Coronel, P; Giménez, MJ; González, N; Prieto, J; Sevillano, D; Torrico, M	1
Bonomo, RA; Distler, AM; Endimiani, A; Hornick, JM; Hujer, AM; Hujer, KM; Papp-Wallace, KM; Taracila, M	1
Geng, SN; Li, TY; Lu, SY; Ye, ZM; Zhang, DS; Zhang, YL; Zhou, HW; Zou, F	1
Moldauer, L; Peterson, C; Riesenberg, R; Rosenthal, J	1
Antunes, NT; Frase, H; Toth, M; Vakulenko, SB; Vakulenko, V	1
Bonomo, RA; Papp-Wallace, KM; Smith, KM; Taracila, MA; Xu, Y	1
He, L; Ke, H; Yuan, Q	1
Drobniewski, F; Gonzalo, X	1
Berbari, E; Huddleston, P; Ramos, A	1
Ducho, C; Gomez-Castellanos, JR; Hamed, RB; Henry, L; McDonough, MA; Schofield, CJ	1
Ahuja, V; Balasubramanian, V; Balganesh, M; Bhattacharjee, D; Dinesh, N; Ganguly, S; Kumar, N; Panduga, V; Parab, M; Ramachandran, V; Reddy, J; Shandil, R; Sharma, S; Solapure, S; Vishwas, KG	1
Andersson, I; Blikstad, C; Demetriades, M; Dubus, A; Généreux, C; Hopkinson, RJ; Iqbal, A; Ivison, D; Kershaw, NJ; Lloyd, AJ; McDonough, MA; Roper, DI; Schofield, CJ; Valegård, K	1
Arthur, M; Cordillot, M; Dubée, V; Dubost, L; Hugonnet, JE; Mainardi, JL; Marie, A; Triboulet, S	1
Bhattacharyya, RP; Hung, DT; Wivagg, CN	1
Kumar, M; Singhal, N; Srivastava, A; Virdi, JS	1
Arthur, M; Ballell, L; Barros, D; Compain, F; Dubée, V; Hugonnet, JE; Li de la Sierra-Gallay, I; Mainardi, JL; Soroka, D; Triboulet, S; van Tilbeurgh, H	1
Raghunand, TR; Viswanathan, G; Yadav, S	1
Alffenaar, JC; Gumbo, T; Srivastava, S; van Rijn, SP; van Soolingen, D; Wessels, MA	1
Ansari, M; Munir, T; Saad, N	1
Chen, PY; Hu, RM; Huang, HH; Li, LH; Lin, YT; Yang, TC	1
Calderón, C; M Munita, J; Martínez, F; Olivares, B; R Campodonico, P; Rivas, L	1
Sharma, AK; Vats, P	1
Chai, J; Chen, S; Cheng, Q; Wai Chi Chan, E; Xu, C; Zhang, R	1
Cardoso, MH; Costa, BO; Franco, OL	1
Abruzzi, J; Kopczynski, A; Montes, THM; Nedel, WL; Portela, LV; Rodolphi, MS; Strogulski, NR	1
Alfandari, S; Bajolet, O; Blanchard, H; Colomb-Cotinat, M; Daniau, C; Dumartin, C; Lecuru, M; Simon, L	1

Reviews

10 review(s) available for clavulanic acid and beta-lactams

Article	Year
The role of beta-lactamase inhibitors in chemotherapy. Pharmacology & therapeutics, 1985, Volume: 30, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Chemical Phenomena; Chemistry; Clavulanic Acid; Clavulanic Acids; Gram-Negative Bacteria; Humans; Lactams; Penicillanic Acid; Sulfones	1985
Naturally occurring beta-lactams. Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles, 1985, Volume: 47 Topics: Anti-Bacterial Agents; beta-Lactams; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Lactams; Penicillins; Thienamycins	1985
[Beta lactamase inhibitors, a new start of antibiotic therapy]. Deutsche medizinische Wochenschrift (1946), 1982, Aug-27, Volume: 107, Issue:34 Topics: beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Resistance, Microbial; Humans; Kinetics; Penicillanic Acid; Sulbactam	1982
Natural beta-lactam antibiotics. Annual review of microbiology, 1980, Volume: 34 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cephalosporins; Cephamycins; Chemical Phenomena; Chemistry; Clavulanic Acid; Lactams; Penicillins; Thienamycins	1980
Amoxycillin/clavulanic acid: a review of its antibacterial activity, pharmacokinetics and therapeutic use. Drugs, 1981, Volume: 22, Issue:5 Topics: Amoxicillin; Animals; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Half-Life; Humans; Intestinal Absorption; Mice; Respiratory Tract Infections; Sexually Transmitted Diseases; Tissue Distribution; Urinary Tract Infections	1981
[Bacterial resistance and pharmacodynamics as the basis for prescribing antibiotics in respiratory infections]. Enfermedades infecciosas y microbiologia clinica, 2004, Volume: 22, Issue:4 Topics: Amoxicillin; Anti-Bacterial Agents; Area Under Curve; Bacterial Infections; beta-Lactams; Clavulanic Acid; Dose-Response Relationship, Drug; Drug Resistance; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Fluoroquinolones; Haemophilus influenzae; Humans; Macrolides; Microbial Sensitivity Tests; Respiratory Tract Infections; Spain; Streptococcus pneumoniae	2004
Diagnosis and treatment of Fusobacterium nucleatum discitis and vertebral osteomyelitis: case report and review of the literature. Spine, 2013, Jan-15, Volume: 38, Issue:2 Topics: Adult; Amoxicillin; Anti-Bacterial Agents; beta-Lactams; Braces; Clavulanic Acid; Combined Modality Therapy; Discitis; Drug Therapy, Combination; Ertapenem; Female; Fusobacterium Infections; Fusobacterium nucleatum; Humans; Intervertebral Disc; Lumbar Vertebrae; Magnetic Resonance Imaging; Microbial Sensitivity Tests; Middle Aged; Osteomyelitis; Treatment Outcome	2013
The enzymes of β-lactam biosynthesis. Natural product reports, 2013, Volume: 30, Issue:1 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cephalosporins; Clavulanic Acid; Humans; Mitosporic Fungi; Molecular Structure; Penicillins	2013
Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis. The Journal of antibiotics, 2014, Volume: 67, Issue:9 Topics: Animals; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Drug Therapy, Combination; Humans; Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant	2014
Development of Peptides that Inhibit Aminoglycoside-Modifying Enzymes and β-Lactamases for Control of Resistant Bacteria. Current protein & peptide science, 2020, Volume: 21, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacterial Infections; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Design; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Kanamycin Kinase; Nucleotidyltransferases; Sulbactam; Tazobactam	2020

Trials

4 trial(s) available for clavulanic acid and beta-lactams

Article	Year
Clavulanic acid and amoxycillin: a clinical, bacteriological, and pharmacological study. Lancet (London, England), 1980, Mar-22, Volume: 1, Issue:8169 Topics: Administration, Oral; Amoxicillin; Bacteriuria; beta-Lactamase Inhibitors; beta-Lactams; Biological Products; Carboxylic Acids; Clavulanic Acid; Clinical Trials as Topic; Drug Combinations; Enterobacteriaceae; Enterobacteriaceae Infections; Enzyme Inhibitors; Humans; Penicillin Resistance; Staphylococcal Infections; Staphylococcus aureus; Streptomyces; Tablets; Urinary Tract Infections	1980
Treatment of chancroid by clavulanic acid with amoxycillin in patients with beta-lactamase-positive Haemophilus ducreyi infection. Lancet (London, England), 1982, Sep-04, Volume: 2, Issue:8297 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Chancroid; Clavulanic Acid; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Haemophilus ducreyi; Humans; Male; Random Allocation	1982
A controlled trial of amoxycillin with clavulanic acid (BRL 25000) against doxycycline in chronic bronchitis. The Journal of international medical research, 1981, Volume: 9, Issue:5 Topics: Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Bronchitis; Clavulanic Acid; Clinical Trials as Topic; Doxycycline; Drug Combinations; Humans; Middle Aged	1981
Results of a proof-of-concept, dose-finding, double-blind, placebo-controlled study of RX-10100 (Serdaxin®) in subjects with major depressive disorder. Psychopharmacology, 2012, Volume: 221, Issue:4 Topics: Adult; Antidepressive Agents; beta-Lactams; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome	2012

Other Studies

88 other study(ies) available for clavulanic acid and beta-lactams

Article	Year
Effect of clavulanic acid and amoxycillin formulation against beta-lactamase producing Gram-negative bacteria in urinary tract infections. The Journal of antimicrobial chemotherapy, 1979, Volume: 5, Issue:6 Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Clavulanic Acid; Escherichia coli; Female; Humans; Middle Aged; Proteus mirabilis; Urinary Tract Infections	1979
Replacement of lysine 234 affects transition state stabilization in the active site of beta-lactamase TEM1. The Journal of biological chemistry, 1991, Sep-15, Volume: 266, Issue:26 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Clavulanic Acid; Clavulanic Acids; DNA, Bacterial; Enzyme Stability; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed	1991
'Beta-lactams' as beta-lactamase inhibitors. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1980, May-16, Volume: 289, Issue:1036 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cephalosporins; Clavulanic Acid; Drug Evaluation, Preclinical; Drug Synergism; Lactams; Penicillins	1980
Beta-lactamase inactivation by mechanism-based reagents. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1980, May-16, Volume: 289, Issue:1036 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Lactams; Penicillanic Acid; Sulbactam	1980
Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:2 Topics: Bacteria; Bacteroides fragilis; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Haemophilus influenzae; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillanic Acid; Penicillins; Pseudomonas aeruginosa; Staphylococcus aureus; Sulbactam	1980
Synergistic activity of piperacillin in combination with beta-lactamase inhibitors. Antimicrobial agents and chemotherapy, 1980, Volume: 18, Issue:4 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Synergism; Penicillanic Acid; Penicillins; Piperacillin; Sulbactam	1980
6-beta-bromo- and 6-beta-iodo penicillanic acid, two novel beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:5 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Penicillanic Acid	1981
Synergistic activity of cefoperazone in combination with beta-lactamase inhibitors. The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cefoperazone; Cefotaxime; Cephalosporins; Clavulanic Acid; Drug Synergism; Penicillanic Acid; Sulbactam	1981
Synthesis and beta-lactamase inhibitory properties of 2 beta-(chloromethyl)-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide. Journal of medicinal chemistry, 1981, Volume: 24, Issue:12 Topics: Amoxicillin; Animals; beta-Lactamase Inhibitors; beta-Lactams; Chemical Phenomena; Chemistry; Clavulanic Acid; Escherichia coli Infections; Mice; Mice, Inbred ICR; Penicillanic Acid; Staphylococcal Infections; Staphylococcus aureus	1981
Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases. The Biochemical journal, 1981, Oct-01, Volume: 199, Issue:1 Topics: Actinomycetaceae; Amdinocillin; beta-Lactams; Carboxypeptidases; Cefoxitin; Cephalosporins; Clavulanic Acid; Drug Interactions; Endopeptidases; Enzyme Inhibitors; Imipenem; Kinetics; Penicillanic Acid; Penicillins; Quinoxalines; Serine-Type D-Ala-D-Ala Carboxypeptidase; Streptomyces; Zinc	1981
The effect of inhibitors of beta-lactamases on beta-lactamase extracts and on intact cells. The Journal of antimicrobial chemotherapy, 1982, Volume: 9, Issue:4 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Cephaloridine; Clavulanic Acid; Hydrolysis; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam	1982
Comparative activity in vitro of piperacillin. The Journal of antimicrobial chemotherapy, 1982, Volume: 9 Suppl B Topics: Bacteria; Bacterial Infections; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Stability; Drug Synergism; Humans; Microbial Sensitivity Tests; Penicillin Resistance; Penicillins; Piperacillin; R Factors	1982
Combinations of clavulanic acid and other beta-lactam antibiotics against strains of Pseudomonas aeruginosa, Serratia marcescens and other bacteria. The Journal of applied bacteriology, 1980, Volume: 49, Issue:1 Topics: beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporins; Clavulanic Acid; Drug Resistance, Microbial; Enterobacter; Enterobacteriaceae; Enzyme Inhibitors; Pseudomonas aeruginosa; Serratia marcescens; Staphylococcus aureus	1980
Inhibition of beta-lactamase in penicillinase producing gonococci by clavulanic acid. The Journal of antimicrobial chemotherapy, 1981, Volume: 8, Issue:1 Topics: beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Neisseria gonorrhoeae	1981
The combination of clavulanic acid and amoxycillin (Augmentin) in the treatment of patients infected with penicillinase producing gonococci. The Journal of antimicrobial chemotherapy, 1981, Volume: 8, Issue:1 Topics: Amoxicillin; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Therapy, Combination; Gonorrhea; Humans; Neisseria gonorrhoeae; Penicillinase	1981
Initial results of in vitro studies of clavulanic acid synergism. Chinese medical journal, 1981, Volume: 94, Issue:9 Topics: Ampicillin; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Carbenicillin; Clavulanic Acid; Drug Synergism; Penicillins	1981
Twenty-one years of beating beta-lactamases. British medical journal (Clinical research ed.), 1982, Feb-06, Volume: 284, Issue:6313 Topics: Amoxicillin; beta-Lactamase Inhibitors; beta-Lactams; Cephalosporins; Clavulanic Acid; Humans; Penicillin Resistance	1982
In vitro activity of BRL 17421 against Haemophilus influenzae, Neisseria gonorrhoeae, and Branhamella catarrhalis. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:1 Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamases; beta-Lactams; Clavulanic Acid; Haemophilus influenzae; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Neisseriaceae; Penicillins	1982
Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains. Antimicrobial agents and chemotherapy, 1980, Volume: 17, Issue:6 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Synergism; Kinetics; Penicillin Resistance	1980
In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:4 Topics: Amoxicillin; Ampicillin; Bacteria; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Synergism; Humans; Penicillins; Protein Binding; Ticarcillin	1980
Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila. Antimicrobial agents and chemotherapy, 1980, Volume: 18, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Synergism; Legionella; Microbial Sensitivity Tests	1980
Clavulanic acid and respiratory infection. The Journal of antimicrobial chemotherapy, 1981, Volume: 7, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Humans; Respiratory Tract Infections	1981
[Indicator method of determining the beta-lactamase-inhibiting activity of various compounds]. Antibiotiki, 1981, Volume: 26, Issue:4 Topics: Actinomycetales; Anti-Bacterial Agents; Bacillus; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Enzyme Activation; Indicators and Reagents; Methods; Time Factors	1981
Synergistic antibacterial activity of clavulanic acid and amoxicillin against beta-lactamase-producing strains of Haemophilus ducreyi. Antimicrobial agents and chemotherapy, 1981, Volume: 20, Issue:1 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Synergism; Haemophilus	1981
Interaction of beta-lactamase of Streptomyces cacaoi. I. Clavulanic acid and PS-5. The Journal of antibiotics, 1981, Volume: 34, Issue:10 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Streptomyces; Thienamycins	1981
Interactions between non-classical beta-lactam compounds and the beta-lactamases of Actinomadura R39 and Streptomyces albus G. The Biochemical journal, 1981, Oct-01, Volume: 199, Issue:1 Topics: Actinomycetaceae; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Hydrolysis; Imipenem; Kinetics; Streptomyces	1981
Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:4 Topics: Amoxicillin; beta-Lactams; Child; Clavulanic Acid; Drug Combinations; Half-Life; Humans; Kinetics; Penicillinase; Suspensions; Time Factors	1982
The history and background of Augmentin. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Jul-28, Volume: 62, Issue:5 Spec No Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Chemical Phenomena; Chemistry; Clavulanic Acid; Drug Combinations; Enzyme Inhibitors; Penicillin Resistance	1982
The in vitro activity of amoxycillin with clavulanic acid against clinically significant bacteria. A multicentre study. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Jul-28, Volume: 62, Issue:5 Spec No Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Penicillin Resistance	1982
[Treatment with amoxicillin and clavulanic acid of urinary tract infections in patients with spinal injuries]. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Jul-28, Volume: 62, Issue:5 Spec No Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Drug Combinations; Enzyme Inhibitors; Humans; Spinal Injuries; Urinary Tract Infections	1982
Amoxicillin and clavulanic acid combination: clinical and laboratory evaluation in pulmonary infections. Clinical therapeutics, 1982, Volume: 4, Issue:6 Topics: Adult; Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; beta-Lactamases; beta-Lactams; Bronchitis; Clavulanic Acid; Drug Combinations; Humans; Microbial Sensitivity Tests; Middle Aged; Pneumonia	1982
beta-Lactamases of Branhamella catarrhalis and their inhibition by clavulanic acid. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:3 Topics: Aerobiosis; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Isoelectric Focusing; Neisseria	1982
A study of clavulanate-amoxicillin synergy using a triple layer technique and enzymatic neutralization. Chemotherapy, 1980, Volume: 26, Issue:3 Topics: Amoxicillin; Bacteria; Bacteriological Techniques; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Culture Media; Drug Synergism; Penicillinase	1980
Inactivation of RTEM beta-lactamase from Escherichia coli by clavulanic acid and 9-deoxyclavulanic acid. Biochemistry, 1981, May-26, Volume: 20, Issue:11 Topics: beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Escherichia coli; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry, Ultraviolet	1981
The inhibition of beta-lactamases from gram-negative bacteria by clavulanic acid. The Biochemical journal, 1981, Dec-01, Volume: 199, Issue:3 Topics: beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Enzyme Inhibitors; Escherichia coli; Kinetics; Substrate Specificity	1981
Susceptibility of Yersinia enterocolitica to eight beta-lactam antibiotics and clavulanic acid. The Journal of antimicrobial chemotherapy, 1981, Volume: 8, Issue:2 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactams; Clavulanic Acid; Drug Interactions; Humans; Microbial Sensitivity Tests; Penicillin G; Yersinia; Yersinia Infections	1981
Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Chromosomes, Bacterial; Clavulanic Acid; Clavulanic Acids; Kinetics; Lactams; Mycobacterium	1994
Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview. The Biochemical journal, 1993, Nov-01, Volume: 295 ( Pt 3) Topics: Actinomycetales; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Clavulanic Acid; Clavulanic Acids; Hydrolysis; Kinetics; Lactams; Serine; Streptomyces; Sulbactam	1993
In-vitro evaluation of the four beta-lactamase inhibitors: BRL42715, clavulanic acid, sulbactam, and tazobactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:3 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Microbial; Escherichia coli; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1993
Effect of five irreversible inhibitors on beta-lactamase from Shigella flexneri UCSF-129. Microbios, 1993, Volume: 76, Issue:308 Topics: Ampicillin; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Synergism; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Shigella flexneri	1993
Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Drug Therapy, Combination; Enzyme Inhibitors; Gram-Negative Bacteria; Lactams; Penicillanic Acid; Sulbactam; Tazobactam	1993
Synthesis and antimicrobial evaluation of 2 beta-chloromethyl-6 beta-carbamoylmethyl-penam-1,1-dioxide-3-carboxylic acid. Farmaco (Societa chimica italiana : 1989), 1996, Volume: 51, Issue:7 Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Clavulanic Acids; Enzyme Inhibitors; Lactams; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Penicillins; Staphylococcus aureus	1996
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases. Journal of medicinal chemistry, 1996, Sep-13, Volume: 39, Issue:19 Topics: beta-Lactamase Inhibitors; beta-Lactams; Ceftriaxone; Citrobacter freundii; Clavulanic Acid; Clavulanic Acids; Crystallography, X-Ray; Drug Design; Drug Synergism; Enterobacter; Enzyme Inhibitors; Lactams; Models, Molecular; Molecular Structure; Pseudomonas; Spectrophotometry, Ultraviolet	1996
Characterization of the inoculum effect with Haemophilus influenzae and beta-lactams. Diagnostic microbiology and infectious disease, 1999, Volume: 33, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactams; Clavulanic Acid; Colony Count, Microbial; Haemophilus influenzae; Humans; Microbial Sensitivity Tests	1999
Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases. The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:1 Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	1999
Penetration of beta-lactamase inhibitors into the periplasm of gram-negative bacteria. FEMS microbiology letters, 1999, Jul-01, Volume: 176, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Cell Membrane Permeability; Clavulanic Acid; Enterobacter cloacae; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Klebsiella pneumoniae; Lactams; Penicillanic Acid; Periplasm; Sulbactam; Tazobactam	1999
Performance of methods for detection of extended-spectrum beta-lactamases applied to clinical enterobacterial strains producing IBC-type beta-lactamases. Journal of clinical microbiology, 2003, Volume: 41, Issue:2 Topics: beta-Lactamases; beta-Lactams; Ceftazidime; Clavulanic Acid; Drug Combinations; Drug Resistance, Bacterial; Enterobacteriaceae; Humans; Microbial Sensitivity Tests	2003
In vitro activities of novel oxapenems, alone and in combination with ceftazidime, against gram-positive and gram-negative organisms. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:8 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Ceftazidime; Cephalosporins; Clavulanic Acid; Drug Synergism; Enterococcus faecalis; Enzyme Inhibitors; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Lactams; Microbial Sensitivity Tests; Staphylococcus aureus	2003
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130. The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52 Topics: Ampicillin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding, Competitive; Clavulanic Acid; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Chemical; Mutagenesis; Mutagenesis, Site-Directed; Penicillanic Acid; Plasmids; Serine; Tazobactam; Thermodynamics; Time Factors	2003
[Phenotypes of beta-lactam resistance in the genus Aeromonas]. Pathologie-biologie, 2003, Volume: 51, Issue:5 Topics: Aeromonas; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Isoelectric Focusing; Isoelectric Point; Lactams; Microbial Sensitivity Tests; Penicillanic Acid; Phenotype; Tazobactam	2003
Pharmacodynamic study of beta-lactams alone and in combination with beta-lactamase inhibitors against Pseudomonas aeruginosa possessing an inducible beta-lactamase. The Journal of antimicrobial chemotherapy, 2004, Volume: 53, Issue:2 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Colony Count, Microbial; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits	2004
[E. coli: resistance to quinolones and beta-lactams of clinical strains isolated in the Franche-Comté region of France]. Pathologie-biologie, 2004, Volume: 52, Issue:2 Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactams; Ceftazidime; Cephalothin; Ciprofloxacin; Clavulanic Acid; Community-Acquired Infections; Cross Infection; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Utilization; Escherichia coli; Escherichia coli Infections; Female; Fluoroquinolones; France; Genotype; Humans; Male; Middle Aged; Nalidixic Acid; Phenotype; Selection, Genetic; Urinary Tract Infections	2004
The vitro efficacy of beta-lactam and beta-lactamase inhibitors against multidrug resistant clinical strains of Mycobacterium tuberculosis. International journal of antimicrobial agents, 2004, Volume: 23, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Culture Media; Drug Resistance, Multiple, Bacterial; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary	2004
In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5 Topics: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; DNA; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Electrophoresis, Gel, Pulsed-Field; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam	2004
Antibiotic susceptibility of coagulase-negative staphylococci isolated from goats' milk. International journal of antimicrobial agents, 2004, Volume: 23, Issue:6 Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Clavulanic Acid; Food Microbiology; Goat Diseases; Goats; Kanamycin; Macrolides; Mastitis; Microbial Sensitivity Tests; Milk; Staphylococcal Infections; Staphylococcus; Staphylococcus epidermidis; Tetracycline	2004
A Bacteroides thetaiotamicron porin that could take part in resistance to beta-lactams. International journal of antimicrobial agents, 2004, Volume: 24, Issue:2 Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroides; beta-Lactam Resistance; beta-Lactams; Clavulanic Acid; Drug Therapy, Combination; Humans; Microbial Sensitivity Tests; Porins	2004
Differential effects of beta-lactams on human IFN-gamma activity. The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:6 Topics: Anti-Bacterial Agents; beta-Lactams; Cell Line; Clavulanic Acid; Epithelial Cells; Humans; Immunologic Factors; Intercellular Adhesion Molecule-1; Interferon-gamma; Penicillin G; Time Factors	2005
Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2006, Volume: 12, Issue:4 Topics: Amoxicillin; Anti-Bacterial Agents; Azithromycin; beta-Lactams; Cefixime; Cefmenoxime; Clarithromycin; Clavulanic Acid; Drug Resistance, Bacterial; Drug Synergism; Erythromycin; Humans; Male; Neisseria gonorrhoeae	2006
Susceptibilities of ESBL-producing Enterobacteriaceae to ertapenem, meropenem and piperacillin-tazobactam with and without clavulanic acid. Chemotherapy, 2007, Volume: 53, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Drug Interactions; Ertapenem; Escherichia coli; Klebsiella pneumoniae; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins	2007
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Acinetobacter; Acinetobacter Infections; Amino Acid Sequence; Anti-Bacterial Agents; Argentina; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Clavulanic Acid; Cloning, Molecular; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA	2007
Sensitivity and specificity of various beta-lactam antibiotics and phenotypical methods for detection of TEM, SHV and CTX-M extended-spectrum beta-lactamases. Journal of chemotherapy (Florence, Italy), 2007, Volume: 19, Issue:2 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Cells, Cultured; Clavulanic Acid; Drug Synergism; Escherichia coli; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Phenotype; Sensitivity and Specificity	2007
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors. Biochemistry, 2007, Jul-24, Volume: 46, Issue:29 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Crystallography, X-Ray; Enzyme Inhibitors; Glycine; Penicillanic Acid; Serine; Spectrum Analysis, Raman; Stereoisomerism; Tazobactam	2007
TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Catalysis; Ceftazidime; Clavulanic Acid; Escherichia coli; Escherichia coli Proteins; Isoenzymes; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Sequence Analysis, DNA	2007
Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. Indian journal of medical microbiology, 2007, Volume: 25, Issue:3 Topics: Acinetobacter; Amoxicillin; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; Enterobacteriaceae; Enzyme Inhibitors; Gram-Negative Bacteria; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Pseudomonas; Stenotrophomonas; Tazobactam; Ticarcillin	2007
A convenient microbiological assay employing cell-free extracts for the rapid characterization of Gram-negative carbapenemase producers. The Journal of antimicrobial chemotherapy, 2008, Volume: 62, Issue:2 Topics: Bacterial Proteins; Bacteriological Techniques; Bacteriolysis; beta-Lactamases; beta-Lactams; Clavulanic Acid; Complex Mixtures; Edetic Acid; Enzyme Inhibitors; Gram-Negative Bacteria; Microspheres; Silicon Dioxide; Substrate Specificity	2008
Induction potential of clavulanic acid toward L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2008, Volume: 27, Issue:12 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Induction; Humans; Microbial Sensitivity Tests; Stenotrophomonas maltophilia	2008
Redefining extended-spectrum beta-lactamases: balancing science and clinical need. The Journal of antimicrobial chemotherapy, 2009, Volume: 63, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Gram-Negative Bacteria; Humans; Substrate Specificity; Terminology as Topic	2009
Beta-lactam effects on mixed cultures of common respiratory isolates as an approach to treatment effects on nasopharyngeal bacterial population dynamics. PloS one, 2008, Volume: 3, Issue:12 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Cells, Cultured; Clavulanic Acid; Computer Simulation; Haemophilus influenzae; Nasopharynx; Respiratory Tract Infections; Streptococcus pneumoniae	2008
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7 Topics: Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporinase; Clavulanic Acid; Computer Simulation; Enzyme Inhibitors; Hydrogen Bonding; Kinetics; Microbial Sensitivity Tests; Molecular Structure; Mutagenesis, Site-Directed; Penicillanic Acid; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulbactam; Tazobactam	2010
High diversity of extended-spectrum beta-lactamase-producing bacteria in an urban river sediment habitat. Applied and environmental microbiology, 2010, Volume: 76, Issue:17 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; beta-Lactamases; beta-Lactams; China; Clavulanic Acid; Cluster Analysis; DNA, Bacterial; DNA, Ribosomal; Ecosystem; Genetic Variation; Geologic Sediments; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Rivers; RNA, Ribosomal, 16S; Sequence Analysis, DNA	2010
Class A carbapenemase FPH-1 from Francisella philomiragia. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Doripenem; Ertapenem; Escherichia coli; Francisella; Imipenem; Meropenem; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam; Thienamycins	2012
Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:8 Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Catalytic Domain; Clavulanic Acid; Klebsiella pneumoniae; Microbial Sensitivity Tests; Protein Structure, Quaternary; Sequence Analysis, Protein; Structure-Activity Relationship	2012
A potential substrate binding conformation of β-lactams and insight into the broad spectrum of NDM-1 activity. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:10 Topics: beta-Lactamases; beta-Lactams; Catalytic Domain; Clavulanic Acid; Klebsiella pneumoniae; Moxalactam; Protein Binding; Protein Conformation	2012
Is there a place for β-lactams in the treatment of multidrug-resistant/extensively drug-resistant tuberculosis? Synergy between meropenem and amoxicillin/clavulanate. The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:2 Topics: Amoxicillin; Anti-Bacterial Agents; beta-Lactams; Clavulanic Acid; Drug Synergism; Humans; Meropenem; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Thienamycins; Tuberculosis, Multidrug-Resistant	2013
In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:6 Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; beta-Lactams; Clavulanic Acid; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Meropenem; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Streptomycin; Thienamycins; Treatment Outcome; Tuberculosis, Pulmonary	2013
Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. Acta crystallographica. Section D, Biological crystallography, 2013, Volume: 69, Issue:Pt 8 Topics: Amino Acid Motifs; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carboxypeptidases; Catalytic Domain; Cephalosporins; Clavulanic Acid; Crystallography, X-Ray; Hydrolysis; Models, Molecular; Penicillins; Protein Conformation; Protein Structure, Tertiary; Serine; Streptomyces	2013
In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12 Topics: Antitubercular Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Carbapenems; Cell Wall; Clavulanic Acid; Doripenem; Enzyme Assays; Ertapenem; Escherichia coli; Gene Expression; Imipenem; Kinetics; Meropenem; Mycobacterium tuberculosis; Peptidoglycan; Peptidyl Transferases; Recombinant Proteins; Thienamycins	2013
Structural Variabilities in β-Lactamase (blaA) of Different Biovars of Yersinia enterocolitica: Implications for β-Lactam Antibiotic and β-Lactamase Inhibitor Susceptibilities. PloS one, 2014, Volume: 10, Issue:4 Topics: Amino Acid Substitution; Amoxicillin; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactams; Clavulanic Acid; DNA-Binding Proteins; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Hydrogen Bonding; Models, Molecular; Molecular Docking Simulation; Nucleic Acid Conformation; Promoter Regions, Genetic; RNA, Messenger; Yersinia enterocolitica	2014
Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:9 Topics: beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Clavulanic Acid; Microbial Sensitivity Tests; Mycobacterium tuberculosis	2015
Identification of Mycobacterial Genes Involved in Antibiotic Sensitivity: Implications for the Treatment of Tuberculosis with β-Lactam-Containing Regimens. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:7 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Clavulanic Acid; Dibenzothiepins; Drug Resistance, Microbial; Meropenem; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Thienamycins; Tuberculosis	2017
Sterilizing Effect of Ertapenem-Clavulanate in a Hollow-Fiber Model of Tuberculosis and Implications on Clinical Dosing. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:9 Topics: Antitubercular Agents; beta-Lactams; Clavulanic Acid; Computer Simulation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ertapenem; Humans; Microbial Sensitivity Tests; Monte Carlo Method; Mycobacterium tuberculosis; Tuberculosis, Multidrug-Resistant	2017
Phenotypic Identification, Frequency Distribution and Antibiogram of Carbapenemase Producing Enterobacteriaceae in Clinical Isolates. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:4 Topics: Amoxicillin; Anti-Bacterial Agents; Aztreonam; Bacterial Proteins; beta-Lactamases; beta-Lactams; Carbapenem-Resistant Enterobacteriaceae; Clavulanic Acid; Disk Diffusion Antimicrobial Tests; Enterobacteriaceae Infections; Humans; Sensitivity and Specificity	2018
Impacts of L1 Promoter Variation and L2 Clavulanate Susceptibility on Ticarcillin-Clavulanate Susceptibility of Stenotrophomonas maltophilia. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:11 Topics: Alleles; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; beta-Lactams; Clavulanic Acid; Genetic Variation; Humans; Microbial Sensitivity Tests; Phylogeny; Promoter Regions, Genetic; Stenotrophomonas maltophilia; Ticarcillin	2018
A Natural Deep Eutectic Solvent Formulated to Stabilize β-Lactam Antibiotics. Scientific reports, 2018, 10-08, Volume: 8, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactams; Betaine; Carbon-13 Magnetic Resonance Spectroscopy; Clavulanic Acid; Escherichia coli; Imipenem; Microbial Sensitivity Tests; Proton Magnetic Resonance Spectroscopy; Pseudomonas aeruginosa; Solvents; Spectroscopy, Fourier Transform Infrared; Urea; Vibration; Water	2018
Evaluation of biochemical and molecular polymorphism in extended spectrum β-lactamases of Mycobacterium tuberculosis clinical isolates. The Indian journal of tuberculosis, 2019, Volume: 66, Issue:1 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Blotting, Southern; Cefotaxime; Cephalosporins; Clavulanic Acid; Humans; Isoelectric Focusing; Kinetics; Mycobacterium tuberculosis; Polymerase Chain Reaction; Tuberculosis	2019
Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S ACS infectious diseases, 2020, 04-10, Volume: 6, Issue:4 Topics: Amino Acid Substitution; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Binding Sites; Catalytic Domain; Clavulanic Acid; Crystallography; Drug Resistance, Multiple, Bacterial; Hydrolysis; Mass Spectrometry; Models, Molecular; Sulbactam	2020
Antibiotic therapy does not alter mitochondrial bioenergetics in lymphocytes of patients with septic shock - A prospective cohort study. Mitochondrion, 2022, Volume: 66 Topics: Amoxicillin; Anti-Bacterial Agents; Azithromycin; beta-Lactams; Clavulanic Acid; Energy Metabolism; Humans; Lymphocytes; Meropenem; Mitochondria; Piperacillin, Tazobactam Drug Combination; Polymyxins; Prospective Studies; Shock, Septic; Vancomycin	2022
Evolution of antibiotic treatments for healthcare-associated infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae in France. Infectious diseases now, 2022, Volume: 52, Issue:7 Topics: Aminoglycosides; Amoxicillin; Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Carbapenems; Clavulanic Acid; Cross Infection; Delivery of Health Care; Enterobacteriaceae; Enterobacteriaceae Infections; France; Humans; Nitrofurantoin; Ofloxacin; Penicillins; Urinary Tract Infections	2022