Compounds > clasto-lactacystin beta-lactone
Page last updated: 2024-09-05

clasto-lactacystin beta-lactone and bortezomib

clasto-lactacystin beta-lactone has been researched along with bortezomib in 2 studies

Compound Research Comparison

Studies
(clasto-lactacystin beta-lactone)		Trials
(clasto-lactacystin beta-lactone)		Recent Studies (post-2010)
(clasto-lactacystin beta-lactone)		Studies
(bortezomib)		Trials
(bortezomib)		Recent Studies (post-2010) (bortezomib)
850156,8688604,753

Protein Interaction Comparison

ProteinTaxonomyclasto-lactacystin beta-lactone (IC50)bortezomib (IC50)
Proteasome subunit beta type-11Homo sapiens (human)0.3213
26S proteasome non-ATPase regulatory subunit 11Homo sapiens (human)0.5335
26S proteasome non-ATPase regulatory subunit 12Homo sapiens (human)0.5335
26S proteasome non-ATPase regulatory subunit 14Homo sapiens (human)0.5335
Proteasome subunit alpha type-7Homo sapiens (human)0.3213
Histone deacetylase 3Homo sapiens (human)1.18
26S proteasome non-ATPase regulatory subunit 3Homo sapiens (human)0.5335
Cathepsin GHomo sapiens (human)1.81
Lysosomal protective proteinHomo sapiens (human)9.2
26S proteasome regulatory subunit 6AHomo sapiens (human)0.5335
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)0.085
Proteasome subunit beta type-1Homo sapiens (human)0.2149
ChymaseHomo sapiens (human)1.19
Proteasome subunit alpha type-1Homo sapiens (human)0.3213
Proteasome subunit alpha type-2Homo sapiens (human)0.3213
Proteasome subunit alpha type-3Homo sapiens (human)0.3213
Proteasome subunit alpha type-4Homo sapiens (human)0.3213
Proteasome subunit beta type-8Homo sapiens (human)0.1681
Proteasome subunit beta type-8Mus musculus (house mouse)0.0168
Proteasome subunit beta type-9Homo sapiens (human)0.2059
Proteasome subunit alpha type-5Homo sapiens (human)0.3213
Proteasome subunit beta type-4Homo sapiens (human)0.3213
Proteasome subunit beta type-6Homo sapiens (human)0.2842
Proteasome subunit beta type-5Homo sapiens (human)0.1407
26S proteasome regulatory subunit 7Homo sapiens (human)0.5335
Lon protease homolog, mitochondrialHomo sapiens (human)0.183
Proteasome subunit beta type-10Homo sapiens (human)0.5359
26S proteasome regulatory subunit 6BHomo sapiens (human)0.5335
26S proteasome non-ATPase regulatory subunit 8Homo sapiens (human)0.5335
Proteasome subunit beta type-3Homo sapiens (human)0.3213
Proteasome subunit beta type-2Homo sapiens (human)0.9297
26S proteasome non-ATPase regulatory subunit 7Homo sapiens (human)0.5335
26S proteasome non-ATPase regulatory subunit 4Homo sapiens (human)0.5335
26S proteasome complex subunit SEM1Homo sapiens (human)0.5335
Proteasome subunit alpha type-6Homo sapiens (human)0.3213
26S proteasome regulatory subunit 4Homo sapiens (human)0.5335
26S proteasome regulatory subunit 8Homo sapiens (human)0.5335
26S proteasome regulatory subunit 10BHomo sapiens (human)0.5335
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)0.085
Transcription factor p65Homo sapiens (human)0.085
26S proteasome non-ATPase regulatory subunit 2Homo sapiens (human)0.5335
Histone deacetylase 1Homo sapiens (human)0.62
26S proteasome non-ATPase regulatory subunit 6Homo sapiens (human)0.5335
Proteasomal ubiquitin receptor ADRM1Homo sapiens (human)0.5335
ATP-dependent Clp protease proteolytic subunitStaphylococcus aureus subsp. aureus NCTC 83255.3
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)0.0407
Proteasome subunit alpha-type 8Homo sapiens (human)0.3213
Histone deacetylase 2Homo sapiens (human)0.8
Proteasome subunit beta type-7Homo sapiens (human)0.3213
26S proteasome non-ATPase regulatory subunit 1Homo sapiens (human)0.5335
Histone deacetylase 8Homo sapiens (human)0.072
26S proteasome non-ATPase regulatory subunit 13Homo sapiens (human)0.5335

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arisawa, M; Asai, A; Groll, M; Kawamura, S; List, A; Mizuno, A; Sasaki, T; Shuto, S; Tanaka, M; Unno, Y1
Chang, CI; Huang, KF; Ihara, K; Kuo, CI; Liao, JH; Wakatsuki, S; Wu, SH1

Other Studies

2 other study(ies) available for clasto-lactacystin beta-lactone and bortezomib

ArticleYear
Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.
    Journal of medicinal chemistry, 2013, May-09, Volume: 56, Issue:9

    Topics: Cell Proliferation; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Cyclopropanes; Drug Stability; HCT116 Cells; Humans; Intercellular Signaling Peptides and Proteins; Isomerism; Models, Molecular; Peptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Conformation; Water

2013
Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors.
    Acta crystallographica. Section D, Biological crystallography, 2013, Volume: 69, Issue:Pt 8

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Bacterial Proteins; Boronic Acids; Bortezomib; Catalytic Domain; Crystallography, X-Ray; Deinococcus; Lactones; Models, Molecular; Molecular Sequence Data; Protease Inhibitors; Protease La; Protein Conformation; Pyrazines

2013