clasto-lactacystin beta-lactone has been researched along with acetylcysteine in 13 studies
| Studies (clasto-lactacystin beta-lactone) | Trials (clasto-lactacystin beta-lactone) | Recent Studies (post-2010) (clasto-lactacystin beta-lactone) | Studies (acetylcysteine) | Trials (acetylcysteine) | Recent Studies (post-2010) (acetylcysteine) |
|---|---|---|---|---|---|
| 85 | 0 | 15 | 14,580 | 1,046 | 5,960 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cruikshank, AA; Dick, LR; Grenier, L; Melandri, FD; Nunes, SL; Stein, RL | 1 |
| Akopian, T; Craiu, A; Fenteany, G; Gaczynska, M; Goldberg, AL; Gramm, CF; Rock, KL | 1 |
| Corey, EJ; Li, WD | 1 |
| Fukuchi, K; Gomi, K; Maruyama, H; Takagi, Y | 1 |
| Omura, S; Tomoda, H | 1 |
| Davies, KJ; Demasi, M; Shringarpure, R | 1 |
| Corey, EJ; Crane, SN | 1 |
| Burrows, J; Hale, PD; Hidvegi, T; Perlmutter, DH; Schmidt, B; Teckman, JH | 1 |
| Davies, KJ; Demasi, M | 1 |
| Itoh, K; Kobayashi, A; Kumagai, T; Kusano, Y; Osada, S; Uchida, K; Usami, H; Yamamoto, M | 1 |
| Balskus, EP; Jacobsen, EN | 1 |
| Blake, AJ; Green, MP; Hayes, CJ; Prodger, JC; Selby, MD; Sherlock, AE; Wilson, C | 1 |
| Gu, W; Silverman, RB | 1 |
1 review(s) available for clasto-lactacystin beta-lactone and acetylcysteine
| Article | Year |
|---|---|
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology.
Topics: Acetylcysteine; Animals; Antigen Presentation; Cell Cycle Proteins; Cell Differentiation; Cell Physiological Phenomena; Circadian Rhythm; Cysteine Endopeptidases; Endoplasmic Reticulum; Lactones; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Structure-Activity Relationship; Ubiquitins | 2000 |
12 other study(ies) available for clasto-lactacystin beta-lactone and acetylcysteine
| Article | Year |
|---|---|
Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactones; Molecular Structure; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rabbits; Reticulocytes; Streptomyces | 1996 |
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antigen Presentation; Base Sequence; beta-Lactams; Cell Line; Cricetinae; Cysteine Endopeptidases; Histocompatibility Antigens Class I; Humans; Lactones; Mice; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex | 1997 |
Total synthesis and biological activity of lactacystin, omuralide and analogs.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cattle; Cysteine Proteinase Inhibitors; Lactams; Lactones; Multienzyme Complexes; Structure-Activity Relationship | 1999 |
Direct proteasome inhibition by clasto-lactacystin beta-lactone permits the detection of ubiquitinated p21(waf1) in ML-1 cells.
Topics: Acetylcysteine; Antibodies; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deferoxamine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Lactones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Ubiquitins | 1999 |
Glutathiolation of the proteasome is enhanced by proteolytic inhibitors.
Topics: Acetylcysteine; Animals; Base Sequence; Clone Cells; Cysteine; Cysteine Endopeptidases; DNA Primers; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; In Vitro Techniques; Lactones; Liver; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; RNA, Messenger; Sulfones | 2001 |
A novel enantioselective synthetic route to omuralide analogues with the potential for species selectivity in proteasome inhibition.
Topics: Acetylcysteine; Catalysis; Cysteine Endopeptidases; Glycine; Lactates; Lactones; Molecular Structure; Multienzyme Complexes; Proteasome Endopeptidase Complex; Stereoisomerism; Structure-Activity Relationship | 2001 |
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; HeLa Cells; Hepatocytes; Humans; Lactones; Leupeptins; Liver; Mice; Multienzyme Complexes; Mutation; Oligopeptides; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Rats; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.
Topics: Acetylcysteine; Animals; Cell Death; Clone Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disulfides; Hydrogen Peroxide; Lactones; Liver; Multienzyme Complexes; Oligopeptides; Oxidants; Oxidative Stress; Oxygen; Proteasome Endopeptidase Complex; Proteins; Rats; Solubility; Sulfones | 2003 |
Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Biomarkers, Tumor; Blotting, Western; Cysteine; DNA-Binding Proteins; DNA, Complementary; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; Glutathione S-Transferase pi; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lactones; Leupeptins; Luciferases; Mice; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Time Factors; Trans-Activators; Transfection; Up-Regulation | 2005 |
Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor.
Topics: Acetylcysteine; Animals; Catalysis; Drug Evaluation, Preclinical; Imides; Lactams; Lactones; Molecular Structure; Protease Inhibitors; Proteasome Inhibitors; Rabbits; Stereoisomerism | 2006 |
Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin.
Topics: Acetylcysteine; Anti-Bacterial Agents; Crystallography, X-Ray; Lactones; Stereoisomerism | 2008 |
Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin.
Topics: Acetylcysteine; Apoptosis; Chemistry, Pharmaceutical; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Humans; Lactones; Magnetic Resonance Spectroscopy; Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Stereoisomerism | 2011 |