Page last updated: 2024-08-25

clarithromycin and simvastatin

clarithromycin has been researched along with simvastatin in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (40.63)	29.6817
2010's	17 (53.13)	24.3611
2020's	2 (6.25)	2.80

Authors

Authors	Studies
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bharate, SS; Vishwakarma, RA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Lee, AJ; Maddix, DS	1
Kahri, AJ; Pentikäinen, PJ; Valkonen, MM; Vuoristo, MK	1
Arias, M; Rodrigo, E; Valero, R; Zubimendi, JA	1
Jacobson, TA	1
Emmett, L; Perera, C; Thanakrishnan, K; Trieu, J; Van Der Wall, H	1
Chakrabarti, S; Chouhan, UM; Millward, LJ	1
Andersson, KS; Molden, E	1
de Sévaux, R; Huussen, J; Ter Laak, H; van der Velden, W	1
Pfister, HW; Suessmair, C; Wagner, J	1
Bodmer, M; Brecht, K; Bur, D; Krähenbühl, S; Tsakiris, DA; Zahno, A	1
Arnold, Ch; Hagmann, N; Lamy, O	1
Abid, A; Abu-Elheja, O; Diab, H; Mahamid, M; Mograbi, J; Nseir, W; Samara, M	1
Chai, CY; Chen, IJ; Chung, PW; Huang, HT; Kuo, MS; Liu, CP; Wu, BN	1
Coombes, I; Martin, JH	1
Page, SR; Yee, KC	1
Chaiwong, K; Lohitnavy, M; Methaneethorn, J; Pongpanich, K; Sonsingh, P	1
Hill, FJ; McCloskey, SJ; Sheerin, N	1
Gouya, G; Herkner, H; Mesgarpour, B; Reichardt, B; Wolzt, M	1
Altaf, S; Javed, I; Kaleem, Z; Khan, JA; Mushtaq, Z	1
Emerson, A; Gonski, P	1
Bykov, K; Gagne, JJ; Kim, S; Li, H; Lo Re, V; Vine, SM	1

Reviews

2 review(s) available for clarithromycin and simvastatin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. The Annals of pharmacotherapy, 2001, Volume: 35, Issue:1 Topics: Anti-Bacterial Agents; Clarithromycin; Drug Interactions; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Rhabdomyolysis; Simvastatin; Sinusitis	2001

Trials

2 trial(s) available for clarithromycin and simvastatin

Article	Year
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. The American journal of cardiology, 2004, Nov-01, Volume: 94, Issue:9 Topics: Adolescent; Adult; Anticholesteremic Agents; Antiprotozoal Agents; Area Under Curve; Atorvastatin; Biomarkers; Calcium Channel Blockers; Clarithromycin; Creatine Kinase; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Male; Mibefradil; Middle Aged; Pravastatin; Protein Synthesis Inhibitors; Pyrroles; Simvastatin; Verapamil	2004
Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study. Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:3 Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Double-Blind Method; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pylori; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Omeprazole; Proton Pump Inhibitors; Simvastatin; Treatment Outcome	2012

Article

Year

Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.

The American journal of cardiology, 2004, Nov-01, Volume: 94, Issue:9

Topics: Adolescent; Adult; Anticholesteremic Agents; Antiprotozoal Agents; Area Under Curve; Atorvastatin; Biomarkers; Calcium Channel Blockers; Clarithromycin; Creatine Kinase; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Male; Mibefradil; Middle Aged; Pravastatin; Protein Synthesis Inhibitors; Pyrroles; Simvastatin; Verapamil

2004

Randomised clinical trial: simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study.

Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:3

Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Double-Blind Method; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pylori; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Omeprazole; Proton Pump Inhibitors; Simvastatin; Treatment Outcome

2012

Other Studies

28 other study(ies) available for clarithromycin and simvastatin

Article	Year
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7 Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics	2015
Rhabdomyolysis associated with concomitant use of simvastatin and clarithromycin. The Annals of pharmacotherapy, 2004, Volume: 38, Issue:4 Topics: Anti-Bacterial Agents; Clarithromycin; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Male; Middle Aged; Rhabdomyolysis; Simvastatin	2004
[Rhabdomyolysis secondary to the interaction of statins with macrolides in a renal transplant patient]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2004, Volume: 24, Issue:4 Topics: Aged; Anticholesteremic Agents; Clarithromycin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Hyperlipidemias; Inactivation, Metabolic; Kidney Transplantation; Male; Postoperative Complications; Respiratory Tract Infections; Rhabdomyolysis; Simvastatin	2004
Rhabdomyolysis resulting from interaction of simvastatin and clarithromycin demonstrated by Tc-99m MDP scintigraphy. Clinical nuclear medicine, 2004, Volume: 29, Issue:12 Topics: Aged; Anti-Bacterial Agents; Clarithromycin; Drug Interactions; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Radionuclide Imaging; Radiopharmaceuticals; Respiratory Tract Infections; Rhabdomyolysis; Simvastatin; Technetium Tc 99m Medronate	2004
Simvastatin interaction with clarithromycin and amiodarone causing myositis. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:10 Topics: Amiodarone; Clarithromycin; Coronary Artery Bypass; Drug Interactions; Humans; Male; Middle Aged; Myositis; Pneumonia; Simvastatin; Tachycardia, Supraventricular	2005
Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. Pharmacotherapy, 2007, Volume: 27, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Clarithromycin; Drug Interactions; Erythromycin; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Rhabdomyolysis; Simvastatin	2007
Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin. The Netherlands journal of medicine, 2008, Volume: 66, Issue:5 Topics: Aged; Anti-Bacterial Agents; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clarithromycin; Colchicine; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Kidney Failure, Chronic; Male; Neuromuscular Diseases; Risk Factors; Simvastatin; Tubulin Modulators	2008
Rhabdomyolysis caused by co-medication with simvastatin and clarithromycin. Journal of neurology, 2009, Volume: 256, Issue:7 Topics: Aged; Anti-Bacterial Agents; Clarithromycin; Contraindications; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iatrogenic Disease; Muscle Weakness; Muscle, Skeletal; Rhabdomyolysis; Risk Factors; Simvastatin	2009
Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro. British journal of pharmacology, 2010, Volume: 161, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Atorvastatin; Clarithromycin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Heptanoic Acids; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Models, Molecular; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Pyrroles; Recombinant Proteins; Simvastatin; Substrate Specificity; Ticlopidine	2010
[88 years old woman with acute muscular weakness and diffuse muscular pain: have you thought about the drugs?]. Praxis, 2010, Dec-01, Volume: 99, Issue:24 Topics: Aged, 80 and over; Anti-Bacterial Agents; Anticholesteremic Agents; Clarithromycin; Diagnosis, Differential; Drug Interactions; Drug Therapy, Combination; Female; Humans; Muscle Weakness; Pain; Rhabdomyolysis; Simvastatin	2010
NO-releasing xanthine KMUP-1 bonded by simvastatin attenuates bleomycin-induced lung inflammation and delayed fibrosis. Pulmonary pharmacology & therapeutics, 2014, Volume: 27, Issue:1 Topics: Animals; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Clarithromycin; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Piperidines; Pneumonia; Pulmonary Fibrosis; Signal Transduction; Simvastatin; Time Factors; Xanthines	2014
Mortality from common drug interactions systems, knowledge and clinical reasoning to optimise prescribing. Internal medicine journal, 2014, Volume: 44, Issue:7 Topics: Clarithromycin; Female; Humans; Rhabdomyolysis; Simvastatin	2014
Rhabdomyolysis in association with simvastatin and dosage increment in clarithromycin. Internal medicine journal, 2014, Volume: 44, Issue:7 Topics: Aged, 80 and over; Clarithromycin; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rhabdomyolysis; Simvastatin	2014
A pharmacokinetic drug-drug interaction model of simvastatin and clarithromycin in humans. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014, Volume: 2014 Topics: Adolescent; Adult; Area Under Curve; Clarithromycin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Models, Biological; Simvastatin; Young Adult	2014
From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions. BMJ case reports, 2015, Jun-23, Volume: 2015 Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Clarithromycin; Drug Interactions; Ethambutol; Finger Injuries; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mycobacterium Infections, Nontuberculous; Renal Dialysis; Rhabdomyolysis; Rifampin; Simvastatin	2015
A population-based analysis of the risk of drug interaction between clarithromycin and statins for hospitalisation or death. Lipids in health and disease, 2015, Oct-24, Volume: 14 Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Clarithromycin; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Dyslipidemias; Female; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pravastatin; Retrospective Studies; Risk; Rosuvastatin Calcium; Simvastatin	2015
Assessment of potential interaction between simvastatin and clarithromycin in healthy adult male subjects. Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:3 Topics: Administration, Oral; Adult; Clarithromycin; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Simvastatin; Young Adult	2018
Polypharmacy induced myositis. Internal medicine journal, 2020, Volume: 50, Issue:1 Topics: Aged, 80 and over; Clarithromycin; Drug Interactions; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myositis; Polypharmacy; Pregabalin; Simvastatin	2020
Drug-Drug Interaction Surveillance Study: Comparing Self-Controlled Designs in Five Empirical Examples in Real-World Data. Clinical pharmacology and therapeutics, 2021, Volume: 109, Issue:5 Topics: Aged; Atorvastatin; Clarithromycin; Dabigatran; Databases, Factual; Drug Evaluation; Drug Interactions; Evidence-Based Medicine; Female; Humans; Male; Middle Aged; Simvastatin; United States; Valsartan	2021